-- dump date 20120504_155452 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1114970000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1114970000002 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 1114970000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970000004 Walker A motif; other site 1114970000005 ATP binding site [chemical binding]; other site 1114970000006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970000007 Walker B motif; other site 1114970000008 arginine finger; other site 1114970000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1114970000010 DnaA box-binding interface [nucleotide binding]; other site 1114970000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1114970000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1114970000013 putative DNA binding surface [nucleotide binding]; other site 1114970000014 dimer interface [polypeptide binding]; other site 1114970000015 beta-clamp/clamp loader binding surface; other site 1114970000016 beta-clamp/translesion DNA polymerase binding surface; other site 1114970000017 recombination protein F; Reviewed; Region: recF; PRK00064 1114970000018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970000019 Walker A/P-loop; other site 1114970000020 ATP binding site [chemical binding]; other site 1114970000021 Q-loop/lid; other site 1114970000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970000023 ABC transporter signature motif; other site 1114970000024 Walker B; other site 1114970000025 D-loop; other site 1114970000026 H-loop/switch region; other site 1114970000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1114970000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970000029 Mg2+ binding site [ion binding]; other site 1114970000030 G-X-G motif; other site 1114970000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1114970000032 anchoring element; other site 1114970000033 dimer interface [polypeptide binding]; other site 1114970000034 ATP binding site [chemical binding]; other site 1114970000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1114970000036 active site 1114970000037 putative metal-binding site [ion binding]; other site 1114970000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1114970000039 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1114970000040 Spore germination protein; Region: Spore_permease; cl15802 1114970000041 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970000042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970000043 active site 1114970000044 phosphorylation site [posttranslational modification] 1114970000045 intermolecular recognition site; other site 1114970000046 dimerization interface [polypeptide binding]; other site 1114970000047 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970000048 DNA binding site [nucleotide binding] 1114970000049 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1114970000050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970000051 dimer interface [polypeptide binding]; other site 1114970000052 phosphorylation site [posttranslational modification] 1114970000053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970000054 ATP binding site [chemical binding]; other site 1114970000055 Mg2+ binding site [ion binding]; other site 1114970000056 G-X-G motif; other site 1114970000057 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114970000058 putative acyl-acceptor binding pocket; other site 1114970000059 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1114970000060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970000061 active site 1114970000062 motif I; other site 1114970000063 motif II; other site 1114970000064 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1114970000065 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114970000066 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1114970000067 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1114970000068 dimer interface [polypeptide binding]; other site 1114970000069 motif 1; other site 1114970000070 active site 1114970000071 motif 2; other site 1114970000072 motif 3; other site 1114970000073 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1114970000074 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1114970000075 putative acyl-acceptor binding pocket; other site 1114970000076 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970000077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970000078 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970000079 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1114970000080 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970000081 classical (c) SDRs; Region: SDR_c; cd05233 1114970000082 NAD(P) binding site [chemical binding]; other site 1114970000083 active site 1114970000084 NIPSNAP; Region: NIPSNAP; pfam07978 1114970000085 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 1114970000086 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970000087 metal binding site [ion binding]; metal-binding site 1114970000088 active site 1114970000089 I-site; other site 1114970000090 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970000091 Helix-turn-helix domains; Region: HTH; cl00088 1114970000092 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970000093 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 1114970000094 putative C-terminal domain interface [polypeptide binding]; other site 1114970000095 putative GSH binding site (G-site) [chemical binding]; other site 1114970000096 putative dimer interface [polypeptide binding]; other site 1114970000097 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 1114970000098 putative N-terminal domain interface [polypeptide binding]; other site 1114970000099 putative dimer interface [polypeptide binding]; other site 1114970000100 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970000101 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 1114970000102 Helix-turn-helix domains; Region: HTH; cl00088 1114970000103 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970000104 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970000105 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970000106 Integrase core domain; Region: rve; cl01316 1114970000107 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970000108 NMT1-like family; Region: NMT1_2; cl15260 1114970000109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000110 dimer interface [polypeptide binding]; other site 1114970000111 conserved gate region; other site 1114970000112 ABC-ATPase subunit interface; other site 1114970000113 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1114970000114 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 1114970000115 Walker A/P-loop; other site 1114970000116 ATP binding site [chemical binding]; other site 1114970000117 Q-loop/lid; other site 1114970000118 ABC transporter signature motif; other site 1114970000119 Walker B; other site 1114970000120 D-loop; other site 1114970000121 H-loop/switch region; other site 1114970000122 NIL domain; Region: NIL; cl09633 1114970000123 hydroperoxidase II; Provisional; Region: katE; PRK11249 1114970000124 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1114970000125 tetramer interface [polypeptide binding]; other site 1114970000126 heme binding pocket [chemical binding]; other site 1114970000127 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1114970000128 domain interactions; other site 1114970000129 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 1114970000130 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1114970000131 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1114970000132 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 1114970000133 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1114970000134 metal binding site 2 [ion binding]; metal-binding site 1114970000135 putative DNA binding helix; other site 1114970000136 metal binding site 1 [ion binding]; metal-binding site 1114970000137 dimer interface [polypeptide binding]; other site 1114970000138 structural Zn2+ binding site [ion binding]; other site 1114970000139 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1114970000140 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1114970000141 metal binding site [ion binding]; metal-binding site 1114970000142 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1114970000143 Phosphotransferase enzyme family; Region: APH; pfam01636 1114970000144 putative active site [active] 1114970000145 putative substrate binding site [chemical binding]; other site 1114970000146 ATP binding site [chemical binding]; other site 1114970000147 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1114970000148 DNA polymerase I; Provisional; Region: PRK05755 1114970000149 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1114970000150 active site 1114970000151 metal binding site 1 [ion binding]; metal-binding site 1114970000152 putative 5' ssDNA interaction site; other site 1114970000153 metal binding site 3; metal-binding site 1114970000154 metal binding site 2 [ion binding]; metal-binding site 1114970000155 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1114970000156 putative DNA binding site [nucleotide binding]; other site 1114970000157 putative metal binding site [ion binding]; other site 1114970000158 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1114970000159 active site 1114970000160 catalytic site [active] 1114970000161 substrate binding site [chemical binding]; other site 1114970000162 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1114970000163 active site 1114970000164 DNA binding site [nucleotide binding] 1114970000165 catalytic site [active] 1114970000166 Predicted GTPase [General function prediction only]; Region: COG0218 1114970000167 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1114970000168 G1 box; other site 1114970000169 GTP/Mg2+ binding site [chemical binding]; other site 1114970000170 Switch I region; other site 1114970000171 G2 box; other site 1114970000172 G3 box; other site 1114970000173 Switch II region; other site 1114970000174 G4 box; other site 1114970000175 G5 box; other site 1114970000176 Cytochrome c; Region: Cytochrom_C; cl11414 1114970000177 Cytochrome c; Region: Cytochrom_C; cl11414 1114970000178 Cytochrome c; Region: Cytochrom_C; cl11414 1114970000179 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1114970000180 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1114970000181 catalytic residues [active] 1114970000182 hinge region; other site 1114970000183 alpha helical domain; other site 1114970000184 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1114970000185 putative catalytic site [active] 1114970000186 putative metal binding site [ion binding]; other site 1114970000187 putative phosphate binding site [ion binding]; other site 1114970000188 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1114970000189 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970000190 metal binding site [ion binding]; metal-binding site 1114970000191 active site 1114970000192 I-site; other site 1114970000193 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1114970000194 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114970000195 amidase catalytic site [active] 1114970000196 Zn binding residues [ion binding]; other site 1114970000197 substrate binding site [chemical binding]; other site 1114970000198 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1114970000199 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1114970000200 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1114970000201 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970000202 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970000203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970000204 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1114970000205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970000206 dimer interface [polypeptide binding]; other site 1114970000207 phosphorylation site [posttranslational modification] 1114970000208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970000209 ATP binding site [chemical binding]; other site 1114970000210 Mg2+ binding site [ion binding]; other site 1114970000211 G-X-G motif; other site 1114970000212 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970000213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970000214 active site 1114970000215 phosphorylation site [posttranslational modification] 1114970000216 intermolecular recognition site; other site 1114970000217 dimerization interface [polypeptide binding]; other site 1114970000218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970000219 Walker A motif; other site 1114970000220 ATP binding site [chemical binding]; other site 1114970000221 Walker B motif; other site 1114970000222 arginine finger; other site 1114970000223 Helix-turn-helix domains; Region: HTH; cl00088 1114970000224 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428 1114970000225 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114970000226 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114970000227 Nucleoside recognition; Region: Gate; cl00486 1114970000228 Nucleoside recognition; Region: Gate; cl00486 1114970000229 Protein of unknown function (DUF330); Region: DUF330; cl01135 1114970000230 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1114970000231 mce related protein; Region: MCE; pfam02470 1114970000232 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1114970000233 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970000234 Walker A/P-loop; other site 1114970000235 ATP binding site [chemical binding]; other site 1114970000236 Q-loop/lid; other site 1114970000237 ABC transporter signature motif; other site 1114970000238 Walker B; other site 1114970000239 D-loop; other site 1114970000240 H-loop/switch region; other site 1114970000241 Permease; Region: Permease; cl00510 1114970000242 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 1114970000243 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114970000244 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1114970000245 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114970000246 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1114970000247 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1114970000248 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1114970000249 PhoU domain; Region: PhoU; pfam01895 1114970000250 Integral membrane protein TerC family; Region: TerC; cl10468 1114970000251 Citrate transporter; Region: CitMHS; pfam03600 1114970000252 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1114970000253 transmembrane helices; other site 1114970000254 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562 1114970000255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970000256 NAD(P) binding site [chemical binding]; other site 1114970000257 active site 1114970000258 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1114970000259 Helix-turn-helix domains; Region: HTH; cl00088 1114970000260 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970000261 dimerization interface [polypeptide binding]; other site 1114970000262 substrate binding pocket [chemical binding]; other site 1114970000263 Sulfatase; Region: Sulfatase; cl10460 1114970000264 choline-sulfatase; Region: chol_sulfatase; TIGR03417 1114970000265 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 1114970000266 NMT1-like family; Region: NMT1_2; cl15260 1114970000267 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1114970000268 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1114970000269 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114970000270 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114970000271 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114970000272 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1114970000273 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1114970000274 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1114970000275 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114970000276 shikimate binding site; other site 1114970000277 NAD(P) binding site [chemical binding]; other site 1114970000278 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 1114970000279 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1114970000280 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1114970000281 NADP binding site [chemical binding]; other site 1114970000282 dimer interface [polypeptide binding]; other site 1114970000283 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1114970000284 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1114970000285 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1114970000286 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114970000287 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1114970000288 active site 1114970000289 catalytic residues [active] 1114970000290 metal binding site [ion binding]; metal-binding site 1114970000291 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1114970000292 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1114970000293 putative active site [active] 1114970000294 substrate binding site [chemical binding]; other site 1114970000295 putative cosubstrate binding site; other site 1114970000296 catalytic site [active] 1114970000297 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1114970000298 substrate binding site [chemical binding]; other site 1114970000299 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1114970000300 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1114970000301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970000302 S-adenosylmethionine binding site [chemical binding]; other site 1114970000303 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1114970000304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970000305 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1114970000306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970000307 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1114970000308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970000309 TPR motif; other site 1114970000310 TPR repeat; Region: TPR_11; pfam13414 1114970000311 binding surface 1114970000312 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970000313 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970000314 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970000315 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970000316 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970000317 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970000318 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 1114970000319 Restriction endonuclease; Region: Mrr_cat; cl00516 1114970000320 Protein of unknown function (DUF867); Region: DUF867; cl01713 1114970000321 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1114970000322 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1114970000323 Cu(I) binding site [ion binding]; other site 1114970000324 UbiA prenyltransferase family; Region: UbiA; cl00337 1114970000325 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1114970000326 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1114970000327 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1114970000328 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1114970000329 Subunit III/VIIa interface [polypeptide binding]; other site 1114970000330 Phospholipid binding site [chemical binding]; other site 1114970000331 Subunit I/III interface [polypeptide binding]; other site 1114970000332 Subunit III/VIb interface [polypeptide binding]; other site 1114970000333 Subunit III/VIa interface; other site 1114970000334 Subunit III/Vb interface [polypeptide binding]; other site 1114970000335 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 1114970000336 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1114970000337 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1114970000338 Subunit I/III interface [polypeptide binding]; other site 1114970000339 D-pathway; other site 1114970000340 Subunit I/VIIc interface [polypeptide binding]; other site 1114970000341 Subunit I/IV interface [polypeptide binding]; other site 1114970000342 Subunit I/II interface [polypeptide binding]; other site 1114970000343 Low-spin heme (heme a) binding site [chemical binding]; other site 1114970000344 Subunit I/VIIa interface [polypeptide binding]; other site 1114970000345 Subunit I/VIa interface [polypeptide binding]; other site 1114970000346 Dimer interface; other site 1114970000347 Putative water exit pathway; other site 1114970000348 Binuclear center (heme a3/CuB) [ion binding]; other site 1114970000349 K-pathway; other site 1114970000350 Subunit I/Vb interface [polypeptide binding]; other site 1114970000351 Putative proton exit pathway; other site 1114970000352 Subunit I/VIb interface; other site 1114970000353 Subunit I/VIc interface [polypeptide binding]; other site 1114970000354 Electron transfer pathway; other site 1114970000355 Subunit I/VIIIb interface [polypeptide binding]; other site 1114970000356 Subunit I/VIIb interface [polypeptide binding]; other site 1114970000357 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1114970000358 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1114970000359 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114970000360 Cytochrome c [Energy production and conversion]; Region: COG3258 1114970000361 Cytochrome c; Region: Cytochrom_C; cl11414 1114970000362 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114970000363 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1114970000364 active site clefts [active] 1114970000365 zinc binding site [ion binding]; other site 1114970000366 dimer interface [polypeptide binding]; other site 1114970000367 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1114970000368 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970000369 FeS/SAM binding site; other site 1114970000370 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1114970000371 active site 1114970000372 catalytic residues [active] 1114970000373 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1114970000374 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1114970000375 Zn binding site [ion binding]; other site 1114970000376 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 1114970000377 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1114970000378 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1114970000379 active site 1114970000380 Zn binding site [ion binding]; other site 1114970000381 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1114970000382 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1114970000383 trimer interface [polypeptide binding]; other site 1114970000384 putative metal binding site [ion binding]; other site 1114970000385 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1114970000386 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114970000387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970000388 motif II; other site 1114970000389 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970000390 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970000391 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1114970000392 active site 1114970000393 homodimer interface [polypeptide binding]; other site 1114970000394 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1114970000395 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1114970000396 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1114970000397 Aspartase; Region: Aspartase; cd01357 1114970000398 active sites [active] 1114970000399 tetramer interface [polypeptide binding]; other site 1114970000400 cell density-dependent motility repressor; Provisional; Region: PRK10082 1114970000401 Helix-turn-helix domains; Region: HTH; cl00088 1114970000402 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970000403 dimerization interface [polypeptide binding]; other site 1114970000404 AIR carboxylase; Region: AIRC; cl00310 1114970000405 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1114970000406 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970000407 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1114970000408 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 1114970000409 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1114970000410 active site 1114970000411 phosphate binding residues; other site 1114970000412 catalytic residues [active] 1114970000413 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1114970000414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970000415 metabolite-proton symporter; Region: 2A0106; TIGR00883 1114970000416 putative substrate translocation pore; other site 1114970000417 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970000418 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1114970000419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1114970000420 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1114970000421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000422 dimer interface [polypeptide binding]; other site 1114970000423 conserved gate region; other site 1114970000424 putative PBP binding loops; other site 1114970000425 ABC-ATPase subunit interface; other site 1114970000426 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1114970000427 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1114970000428 Walker A/P-loop; other site 1114970000429 ATP binding site [chemical binding]; other site 1114970000430 Q-loop/lid; other site 1114970000431 ABC transporter signature motif; other site 1114970000432 Walker B; other site 1114970000433 D-loop; other site 1114970000434 H-loop/switch region; other site 1114970000435 transcriptional regulator PhoU; Provisional; Region: PRK11115 1114970000436 PhoU domain; Region: PhoU; pfam01895 1114970000437 PhoU domain; Region: PhoU; pfam01895 1114970000438 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970000439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970000440 active site 1114970000441 phosphorylation site [posttranslational modification] 1114970000442 intermolecular recognition site; other site 1114970000443 dimerization interface [polypeptide binding]; other site 1114970000444 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1114970000445 Peptidase family M23; Region: Peptidase_M23; pfam01551 1114970000446 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114970000447 gliding motility-associated protein GldE; Region: GldE; TIGR03520 1114970000448 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114970000449 Transporter associated domain; Region: CorC_HlyC; cl08393 1114970000450 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1114970000451 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1114970000452 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970000453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970000454 dimer interface [polypeptide binding]; other site 1114970000455 phosphorylation site [posttranslational modification] 1114970000456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970000457 ATP binding site [chemical binding]; other site 1114970000458 Mg2+ binding site [ion binding]; other site 1114970000459 G-X-G motif; other site 1114970000460 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1114970000461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970000462 active site 1114970000463 phosphorylation site [posttranslational modification] 1114970000464 intermolecular recognition site; other site 1114970000465 dimerization interface [polypeptide binding]; other site 1114970000466 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970000467 DNA binding site [nucleotide binding] 1114970000468 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1114970000469 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1114970000470 UbiA prenyltransferase family; Region: UbiA; cl00337 1114970000471 UTRA domain; Region: UTRA; cl01230 1114970000472 Rubredoxin [Energy production and conversion]; Region: COG1773 1114970000473 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1114970000474 iron binding site [ion binding]; other site 1114970000475 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1114970000476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970000477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970000478 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114970000479 IHF dimer interface [polypeptide binding]; other site 1114970000480 IHF - DNA interface [nucleotide binding]; other site 1114970000481 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 1114970000482 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1114970000483 OsmC-like protein; Region: OsmC; cl00767 1114970000484 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1114970000485 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114970000486 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1114970000487 Dodecin; Region: Dodecin; cl01328 1114970000488 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1114970000489 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970000490 Helix-turn-helix domains; Region: HTH; cl00088 1114970000491 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970000492 dimerization interface [polypeptide binding]; other site 1114970000493 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1114970000494 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1114970000495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970000496 catalytic residue [active] 1114970000497 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 1114970000498 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1114970000499 substrate binding site [chemical binding]; other site 1114970000500 active site 1114970000501 catalytic residues [active] 1114970000502 heterodimer interface [polypeptide binding]; other site 1114970000503 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1114970000504 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 1114970000505 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 1114970000506 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 1114970000507 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1114970000508 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 1114970000509 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114970000510 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1114970000511 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1114970000512 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1114970000513 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1114970000514 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 1114970000515 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114970000516 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970000517 Helix-turn-helix domains; Region: HTH; cl00088 1114970000518 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1114970000519 dimerization interface [polypeptide binding]; other site 1114970000520 substrate binding pocket [chemical binding]; other site 1114970000521 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1114970000522 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970000523 FAD binding site [chemical binding]; other site 1114970000524 substrate binding pocket [chemical binding]; other site 1114970000525 catalytic base [active] 1114970000526 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1114970000527 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1114970000528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339; cl15420 1114970000529 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1114970000530 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 1114970000531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970000532 binding surface 1114970000533 TPR motif; other site 1114970000534 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 1114970000535 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1114970000536 putative active site [active] 1114970000537 putative metal binding site [ion binding]; other site 1114970000538 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 1114970000539 N-glycosyltransferase; Provisional; Region: PRK11204 1114970000540 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1114970000541 DXD motif; other site 1114970000542 PgaD-like protein; Region: PgaD; cl14676 1114970000543 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 1114970000544 [2Fe-2S] cluster binding site [ion binding]; other site 1114970000545 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1114970000546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970000547 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1114970000548 substrate binding site [chemical binding]; other site 1114970000549 metabolite-proton symporter; Region: 2A0106; TIGR00883 1114970000550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970000551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970000552 Helix-turn-helix domains; Region: HTH; cl00088 1114970000553 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970000554 putative effector binding pocket; other site 1114970000555 dimerization interface [polypeptide binding]; other site 1114970000556 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1114970000557 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114970000558 putative NAD(P) binding site [chemical binding]; other site 1114970000559 von Willebrand factor; Region: vWF_A; pfam12450 1114970000560 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1114970000561 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1114970000562 metal ion-dependent adhesion site (MIDAS); other site 1114970000563 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1114970000564 RNA polymerase sigma factor; Provisional; Region: PRK12513 1114970000565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970000566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970000567 DNA binding residues [nucleotide binding] 1114970000568 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970000569 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1114970000570 tetramerization interface [polypeptide binding]; other site 1114970000571 NAD(P) binding site [chemical binding]; other site 1114970000572 catalytic residues [active] 1114970000573 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1114970000574 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970000575 inhibitor-cofactor binding pocket; inhibition site 1114970000576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970000577 catalytic residue [active] 1114970000578 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970000579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970000580 active site 1114970000581 phosphorylation site [posttranslational modification] 1114970000582 intermolecular recognition site; other site 1114970000583 dimerization interface [polypeptide binding]; other site 1114970000584 HDOD domain; Region: HDOD; pfam08668 1114970000585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970000586 PAS fold; Region: PAS_3; pfam08447 1114970000587 putative active site [active] 1114970000588 heme pocket [chemical binding]; other site 1114970000589 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970000590 metal binding site [ion binding]; metal-binding site 1114970000591 active site 1114970000592 I-site; other site 1114970000593 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1114970000594 Di-iron ligands [ion binding]; other site 1114970000595 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1114970000596 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1114970000597 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1114970000598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970000599 PAS domain; Region: PAS_9; pfam13426 1114970000600 putative active site [active] 1114970000601 heme pocket [chemical binding]; other site 1114970000602 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970000603 metal binding site [ion binding]; metal-binding site 1114970000604 active site 1114970000605 I-site; other site 1114970000606 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970000607 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114970000608 MULE transposase domain; Region: MULE; pfam10551 1114970000609 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 1114970000610 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970000611 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1114970000612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000613 dimer interface [polypeptide binding]; other site 1114970000614 conserved gate region; other site 1114970000615 putative PBP binding loops; other site 1114970000616 ABC-ATPase subunit interface; other site 1114970000617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000618 dimer interface [polypeptide binding]; other site 1114970000619 conserved gate region; other site 1114970000620 putative PBP binding loops; other site 1114970000621 ABC-ATPase subunit interface; other site 1114970000622 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1114970000623 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 1114970000624 Walker A/P-loop; other site 1114970000625 ATP binding site [chemical binding]; other site 1114970000626 Q-loop/lid; other site 1114970000627 ABC transporter signature motif; other site 1114970000628 Walker B; other site 1114970000629 D-loop; other site 1114970000630 H-loop/switch region; other site 1114970000631 TOBE-like domain; Region: TOBE_3; pfam12857 1114970000632 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1114970000633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970000634 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970000635 Protein of unknown function (DUF962); Region: DUF962; cl01879 1114970000636 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1114970000637 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970000638 ligand binding site [chemical binding]; other site 1114970000639 Helix-turn-helix domains; Region: HTH; cl00088 1114970000640 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970000641 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970000642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970000643 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1114970000644 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1114970000645 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970000646 N-terminal plug; other site 1114970000647 ligand-binding site [chemical binding]; other site 1114970000648 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970000649 FecR protein; Region: FecR; pfam04773 1114970000650 RNA polymerase sigma factor; Provisional; Region: PRK12528 1114970000651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970000652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970000653 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1114970000654 Cache domain; Region: Cache_1; pfam02743 1114970000655 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970000656 dimerization interface [polypeptide binding]; other site 1114970000657 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970000658 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970000659 dimer interface [polypeptide binding]; other site 1114970000660 putative CheW interface [polypeptide binding]; other site 1114970000661 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1114970000662 putative hydrophobic ligand binding site [chemical binding]; other site 1114970000663 protein interface [polypeptide binding]; other site 1114970000664 gate; other site 1114970000665 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1114970000666 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970000667 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970000668 thioester reductase domain; Region: Thioester-redct; TIGR01746 1114970000669 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1114970000670 putative NAD(P) binding site [chemical binding]; other site 1114970000671 active site 1114970000672 putative substrate binding site [chemical binding]; other site 1114970000673 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1114970000674 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 1114970000675 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970000676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970000677 DNA-binding site [nucleotide binding]; DNA binding site 1114970000678 FCD domain; Region: FCD; cl11656 1114970000679 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1114970000680 biofilm formation regulator HmsP; Provisional; Region: PRK11829 1114970000681 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970000682 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970000683 metal binding site [ion binding]; metal-binding site 1114970000684 active site 1114970000685 I-site; other site 1114970000686 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970000687 Calx-beta domain; Region: Calx-beta; cl02522 1114970000688 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114970000689 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970000690 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1114970000691 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1114970000692 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421 1114970000693 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1114970000694 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114970000695 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970000696 Walker A/P-loop; other site 1114970000697 ATP binding site [chemical binding]; other site 1114970000698 Q-loop/lid; other site 1114970000699 ABC transporter signature motif; other site 1114970000700 Walker B; other site 1114970000701 D-loop; other site 1114970000702 H-loop/switch region; other site 1114970000703 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1114970000704 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970000705 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970000706 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1114970000707 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1114970000708 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1114970000709 NMT1-like family; Region: NMT1_2; cl15260 1114970000710 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1114970000711 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1114970000712 Walker A/P-loop; other site 1114970000713 ATP binding site [chemical binding]; other site 1114970000714 Q-loop/lid; other site 1114970000715 ABC transporter signature motif; other site 1114970000716 Walker B; other site 1114970000717 D-loop; other site 1114970000718 H-loop/switch region; other site 1114970000719 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1114970000720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000721 dimer interface [polypeptide binding]; other site 1114970000722 conserved gate region; other site 1114970000723 putative PBP binding loops; other site 1114970000724 ABC-ATPase subunit interface; other site 1114970000725 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114970000726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970000727 TIGR01777 family protein; Region: yfcH 1114970000728 NAD(P) binding site [chemical binding]; other site 1114970000729 active site 1114970000730 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970000731 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1114970000732 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970000733 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970000734 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1114970000735 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970000736 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970000737 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1114970000738 active site 1114970000739 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970000740 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970000741 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970000742 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970000743 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1114970000744 Phage Tail Collar Domain; Region: Collar; pfam07484 1114970000745 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1114970000746 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1114970000747 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1114970000748 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1114970000749 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1114970000750 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1114970000751 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1114970000752 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1114970000753 Cupin domain; Region: Cupin_2; cl09118 1114970000754 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1114970000755 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1114970000756 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1114970000757 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970000758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970000759 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114970000760 Walker A motif; other site 1114970000761 ATP binding site [chemical binding]; other site 1114970000762 Walker B motif; other site 1114970000763 arginine finger; other site 1114970000764 NMT1-like family; Region: NMT1_2; cl15260 1114970000765 Predicted ATPase [General function prediction only]; Region: COG4637 1114970000766 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970000767 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970000768 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970000769 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970000770 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970000771 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970000772 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1114970000773 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114970000774 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114970000775 metal-binding site [ion binding] 1114970000776 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114970000777 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114970000778 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1114970000779 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1114970000780 DNA binding residues [nucleotide binding] 1114970000781 dimer interface [polypeptide binding]; other site 1114970000782 putative metal binding site [ion binding]; other site 1114970000783 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1114970000784 dimerization interface [polypeptide binding]; other site 1114970000785 active site 1114970000786 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1114970000787 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1114970000788 NRDE protein; Region: NRDE; cl01315 1114970000789 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1114970000790 GAF domain; Region: GAF; cl15785 1114970000791 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1114970000792 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1114970000793 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1114970000794 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1114970000795 putative active site [active] 1114970000796 Ap4A binding site [chemical binding]; other site 1114970000797 nudix motif; other site 1114970000798 putative metal binding site [ion binding]; other site 1114970000799 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1114970000800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970000801 motif II; other site 1114970000802 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 1114970000803 threonine dehydratase; Reviewed; Region: PRK09224 1114970000804 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1114970000805 tetramer interface [polypeptide binding]; other site 1114970000806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970000807 catalytic residue [active] 1114970000808 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1114970000809 putative Ile/Val binding site [chemical binding]; other site 1114970000810 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1114970000811 putative Ile/Val binding site [chemical binding]; other site 1114970000812 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1114970000813 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114970000814 active site 1114970000815 dimer interface [polypeptide binding]; other site 1114970000816 SdiA-regulated; Region: SdiA-regulated; pfam06977 1114970000817 SdiA-regulated; Region: SdiA-regulated; cd09971 1114970000818 putative active site [active] 1114970000819 SdiA-regulated; Region: SdiA-regulated; pfam06977 1114970000820 SdiA-regulated; Region: SdiA-regulated; cd09971 1114970000821 putative active site [active] 1114970000822 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970000823 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114970000824 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970000825 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1114970000826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970000827 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1114970000828 L-serine binding site [chemical binding]; other site 1114970000829 ACT domain interface; other site 1114970000830 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1114970000831 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1114970000832 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970000833 substrate binding pocket [chemical binding]; other site 1114970000834 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 1114970000835 hinge residues; other site 1114970000836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970000837 S-adenosylmethionine binding site [chemical binding]; other site 1114970000838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000839 dimer interface [polypeptide binding]; other site 1114970000840 conserved gate region; other site 1114970000841 ABC-ATPase subunit interface; other site 1114970000842 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1114970000843 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 1114970000844 Walker A/P-loop; other site 1114970000845 ATP binding site [chemical binding]; other site 1114970000846 Q-loop/lid; other site 1114970000847 ABC transporter signature motif; other site 1114970000848 Walker B; other site 1114970000849 D-loop; other site 1114970000850 H-loop/switch region; other site 1114970000851 NIL domain; Region: NIL; cl09633 1114970000852 NMT1-like family; Region: NMT1_2; cl15260 1114970000853 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1114970000854 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1114970000855 active site 1114970000856 non-prolyl cis peptide bond; other site 1114970000857 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1114970000858 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1114970000859 Flavin binding site [chemical binding]; other site 1114970000860 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1114970000861 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970000862 active site 1114970000863 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1114970000864 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970000865 Walker A/P-loop; other site 1114970000866 ATP binding site [chemical binding]; other site 1114970000867 Q-loop/lid; other site 1114970000868 ABC transporter signature motif; other site 1114970000869 Walker B; other site 1114970000870 D-loop; other site 1114970000871 H-loop/switch region; other site 1114970000872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000873 dimer interface [polypeptide binding]; other site 1114970000874 conserved gate region; other site 1114970000875 putative PBP binding loops; other site 1114970000876 ABC-ATPase subunit interface; other site 1114970000877 cystine transporter subunit; Provisional; Region: PRK11260 1114970000878 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970000879 substrate binding pocket [chemical binding]; other site 1114970000880 membrane-bound complex binding site; other site 1114970000881 hinge residues; other site 1114970000882 D-cysteine desulfhydrase; Validated; Region: PRK03910 1114970000883 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1114970000884 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970000885 catalytic residue [active] 1114970000886 BCCT family transporter; Region: BCCT; cl00569 1114970000887 short chain dehydrogenase; Provisional; Region: PRK12937 1114970000888 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1114970000889 NADP binding site [chemical binding]; other site 1114970000890 homodimer interface [polypeptide binding]; other site 1114970000891 active site 1114970000892 substrate binding site [chemical binding]; other site 1114970000893 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970000894 Helix-turn-helix domains; Region: HTH; cl00088 1114970000895 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1114970000896 putative effector binding pocket; other site 1114970000897 putative dimerization interface [polypeptide binding]; other site 1114970000898 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1114970000899 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970000900 active site 1114970000901 catalytic tetrad [active] 1114970000902 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1114970000903 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1114970000904 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1114970000905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000906 dimer interface [polypeptide binding]; other site 1114970000907 conserved gate region; other site 1114970000908 putative PBP binding loops; other site 1114970000909 ABC-ATPase subunit interface; other site 1114970000910 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1114970000911 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1114970000912 Walker A/P-loop; other site 1114970000913 ATP binding site [chemical binding]; other site 1114970000914 Q-loop/lid; other site 1114970000915 ABC transporter signature motif; other site 1114970000916 Walker B; other site 1114970000917 D-loop; other site 1114970000918 H-loop/switch region; other site 1114970000919 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1114970000920 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970000921 substrate binding pocket [chemical binding]; other site 1114970000922 membrane-bound complex binding site; other site 1114970000923 hinge residues; other site 1114970000924 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1114970000925 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114970000926 CoenzymeA binding site [chemical binding]; other site 1114970000927 subunit interaction site [polypeptide binding]; other site 1114970000928 PHB binding site; other site 1114970000929 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1114970000930 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1114970000931 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1114970000932 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1114970000933 RNA binding site [nucleotide binding]; other site 1114970000934 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1114970000935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970000936 active site 1114970000937 phosphorylation site [posttranslational modification] 1114970000938 intermolecular recognition site; other site 1114970000939 dimerization interface [polypeptide binding]; other site 1114970000940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970000941 DNA binding site [nucleotide binding] 1114970000942 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1114970000943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970000944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970000945 ATP binding site [chemical binding]; other site 1114970000946 Mg2+ binding site [ion binding]; other site 1114970000947 G-X-G motif; other site 1114970000948 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1114970000949 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970000950 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 1114970000951 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114970000952 RNA binding surface [nucleotide binding]; other site 1114970000953 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1114970000954 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1114970000955 dimerization interface [polypeptide binding]; other site 1114970000956 domain crossover interface; other site 1114970000957 redox-dependent activation switch; other site 1114970000958 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1114970000959 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1114970000960 active site 1114970000961 substrate-binding site [chemical binding]; other site 1114970000962 metal-binding site [ion binding] 1114970000963 ATP binding site [chemical binding]; other site 1114970000964 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1114970000965 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1114970000966 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970000967 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970000968 S-type Pyocin; Region: Pyocin_S; pfam06958 1114970000969 Cytotoxic; Region: Cytotoxic; pfam09000 1114970000970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970000971 ATP binding site [chemical binding]; other site 1114970000972 putative Mg++ binding site [ion binding]; other site 1114970000973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970000974 nucleotide binding region [chemical binding]; other site 1114970000975 ATP-binding site [chemical binding]; other site 1114970000976 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1114970000977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970000978 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970000979 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1114970000980 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970000981 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114970000982 active site 1114970000983 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1114970000984 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1114970000985 putative molybdopterin cofactor binding site [chemical binding]; other site 1114970000986 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1114970000987 putative molybdopterin cofactor binding site; other site 1114970000988 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1114970000989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970000990 Helix-turn-helix domains; Region: HTH; cl00088 1114970000991 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970000992 dimerization interface [polypeptide binding]; other site 1114970000993 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1114970000994 BON domain; Region: BON; cl02771 1114970000995 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114970000996 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1114970000997 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970000998 motif II; other site 1114970000999 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1114970001000 dimer interface [polypeptide binding]; other site 1114970001001 ADP-ribose binding site [chemical binding]; other site 1114970001002 active site 1114970001003 nudix motif; other site 1114970001004 metal binding site [ion binding]; metal-binding site 1114970001005 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 1114970001006 active site 1114970001007 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1114970001008 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970001009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970001010 active site 1114970001011 phosphorylation site [posttranslational modification] 1114970001012 intermolecular recognition site; other site 1114970001013 dimerization interface [polypeptide binding]; other site 1114970001014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970001015 Walker A motif; other site 1114970001016 ATP binding site [chemical binding]; other site 1114970001017 Walker B motif; other site 1114970001018 arginine finger; other site 1114970001019 Helix-turn-helix domains; Region: HTH; cl00088 1114970001020 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1114970001021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970001022 dimer interface [polypeptide binding]; other site 1114970001023 phosphorylation site [posttranslational modification] 1114970001024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970001025 ATP binding site [chemical binding]; other site 1114970001026 G-X-G motif; other site 1114970001027 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1114970001028 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1114970001029 NADP binding site [chemical binding]; other site 1114970001030 active site 1114970001031 putative substrate binding site [chemical binding]; other site 1114970001032 Cupin domain; Region: Cupin_2; cl09118 1114970001033 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1114970001034 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1114970001035 substrate binding site; other site 1114970001036 tetramer interface; other site 1114970001037 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1114970001038 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1114970001039 NAD binding site [chemical binding]; other site 1114970001040 substrate binding site [chemical binding]; other site 1114970001041 homodimer interface [polypeptide binding]; other site 1114970001042 active site 1114970001043 hypothetical protein; Provisional; Region: PRK06149 1114970001044 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970001045 active site 1114970001046 ATP binding site [chemical binding]; other site 1114970001047 substrate binding site [chemical binding]; other site 1114970001048 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970001049 inhibitor-cofactor binding pocket; inhibition site 1114970001050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970001051 catalytic residue [active] 1114970001052 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 1114970001053 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1114970001054 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1114970001055 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1114970001056 catalytic residues [active] 1114970001057 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970001058 Biofilm formation and stress response factor; Region: BsmA; cl01794 1114970001059 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114970001060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970001061 Coenzyme A binding pocket [chemical binding]; other site 1114970001062 AzlC protein; Region: AzlC; cl00570 1114970001063 Helix-turn-helix domains; Region: HTH; cl00088 1114970001064 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970001065 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 1114970001066 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1114970001067 RES domain; Region: RES; cl02411 1114970001068 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970001069 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970001070 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970001071 dimer interface [polypeptide binding]; other site 1114970001072 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1114970001073 putative CheW interface [polypeptide binding]; other site 1114970001074 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1114970001075 TIGR04255 family protein; Region: sporadTIGR04255 1114970001076 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1114970001077 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1114970001078 active site 1114970001079 Int/Topo IB signature motif; other site 1114970001080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970001081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970001082 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970001083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970001084 dimer interface [polypeptide binding]; other site 1114970001085 conserved gate region; other site 1114970001086 putative PBP binding loops; other site 1114970001087 ABC-ATPase subunit interface; other site 1114970001088 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970001089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970001090 dimer interface [polypeptide binding]; other site 1114970001091 conserved gate region; other site 1114970001092 putative PBP binding loops; other site 1114970001093 ABC-ATPase subunit interface; other site 1114970001094 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970001095 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970001096 substrate binding pocket [chemical binding]; other site 1114970001097 membrane-bound complex binding site; other site 1114970001098 hinge residues; other site 1114970001099 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1114970001100 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970001101 Walker A/P-loop; other site 1114970001102 ATP binding site [chemical binding]; other site 1114970001103 Q-loop/lid; other site 1114970001104 ABC transporter signature motif; other site 1114970001105 Walker B; other site 1114970001106 D-loop; other site 1114970001107 H-loop/switch region; other site 1114970001108 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1114970001109 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 1114970001110 adenine DNA glycosylase; Provisional; Region: PRK10880 1114970001111 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114970001112 minor groove reading motif; other site 1114970001113 helix-hairpin-helix signature motif; other site 1114970001114 substrate binding pocket [chemical binding]; other site 1114970001115 active site 1114970001116 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1114970001117 DNA binding and oxoG recognition site [nucleotide binding] 1114970001118 AsmA family; Region: AsmA; pfam05170 1114970001119 AsmA-like C-terminal region; Region: AsmA_2; cl15864 1114970001120 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970001121 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1114970001122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970001123 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 1114970001124 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1114970001125 putative active site pocket [active] 1114970001126 4-fold oligomerization interface [polypeptide binding]; other site 1114970001127 metal binding residues [ion binding]; metal-binding site 1114970001128 3-fold/trimer interface [polypeptide binding]; other site 1114970001129 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1114970001130 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1114970001131 putative active site [active] 1114970001132 oxyanion strand; other site 1114970001133 catalytic triad [active] 1114970001134 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 1114970001135 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 1114970001136 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1114970001137 catalytic residues [active] 1114970001138 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1114970001139 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1114970001140 substrate binding site [chemical binding]; other site 1114970001141 glutamase interaction surface [polypeptide binding]; other site 1114970001142 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970001143 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970001144 substrate binding pocket [chemical binding]; other site 1114970001145 membrane-bound complex binding site; other site 1114970001146 hinge residues; other site 1114970001147 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1114970001148 NodB motif; other site 1114970001149 putative active site [active] 1114970001150 putative catalytic site [active] 1114970001151 Zn binding site [ion binding]; other site 1114970001152 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1114970001153 C-terminal peptidase (prc); Region: prc; TIGR00225 1114970001154 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1114970001155 protein binding site [polypeptide binding]; other site 1114970001156 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1114970001157 Catalytic dyad [active] 1114970001158 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1114970001159 Sulfatase; Region: Sulfatase; cl10460 1114970001160 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1114970001161 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114970001162 active site residue [active] 1114970001163 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1114970001164 GSH binding site [chemical binding]; other site 1114970001165 catalytic residues [active] 1114970001166 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1114970001167 SecA binding site; other site 1114970001168 Preprotein binding site; other site 1114970001169 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1114970001170 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1114970001171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970001172 active site 1114970001173 phosphorylation site [posttranslational modification] 1114970001174 intermolecular recognition site; other site 1114970001175 dimerization interface [polypeptide binding]; other site 1114970001176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970001177 Walker A motif; other site 1114970001178 ATP binding site [chemical binding]; other site 1114970001179 Walker B motif; other site 1114970001180 arginine finger; other site 1114970001181 Helix-turn-helix domains; Region: HTH; cl00088 1114970001182 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1114970001183 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970001184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970001185 dimer interface [polypeptide binding]; other site 1114970001186 phosphorylation site [posttranslational modification] 1114970001187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970001188 ATP binding site [chemical binding]; other site 1114970001189 Mg2+ binding site [ion binding]; other site 1114970001190 G-X-G motif; other site 1114970001191 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1114970001192 Chorismate mutase type II; Region: CM_2; cl00693 1114970001193 glutamine synthetase; Provisional; Region: glnA; PRK09469 1114970001194 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1114970001195 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970001196 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1114970001197 THUMP domain; Region: THUMP; cl12076 1114970001198 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1114970001199 Ligand Binding Site [chemical binding]; other site 1114970001200 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1114970001201 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1114970001202 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1114970001203 G1 box; other site 1114970001204 putative GEF interaction site [polypeptide binding]; other site 1114970001205 GTP/Mg2+ binding site [chemical binding]; other site 1114970001206 Switch I region; other site 1114970001207 G2 box; other site 1114970001208 G3 box; other site 1114970001209 Switch II region; other site 1114970001210 G4 box; other site 1114970001211 G5 box; other site 1114970001212 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1114970001213 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1114970001214 Flagellin N-methylase; Region: FliB; cl00497 1114970001215 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1114970001216 homodimer interface [polypeptide binding]; other site 1114970001217 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1114970001218 active site pocket [active] 1114970001219 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1114970001220 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1114970001221 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1114970001222 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1114970001223 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1114970001224 AMP binding site [chemical binding]; other site 1114970001225 metal binding site [ion binding]; metal-binding site 1114970001226 active site 1114970001227 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 1114970001228 Cache domain; Region: Cache_1; pfam02743 1114970001229 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970001230 dimerization interface [polypeptide binding]; other site 1114970001231 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970001232 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970001233 dimer interface [polypeptide binding]; other site 1114970001234 putative CheW interface [polypeptide binding]; other site 1114970001235 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 1114970001236 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 1114970001237 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1114970001238 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1114970001239 active site 1114970001240 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1114970001241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970001242 DNA-binding site [nucleotide binding]; DNA binding site 1114970001243 UTRA domain; Region: UTRA; cl01230 1114970001244 HutD; Region: HutD; cl01532 1114970001245 urocanate hydratase; Provisional; Region: PRK05414 1114970001246 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114970001247 Na binding site [ion binding]; other site 1114970001248 NMT1-like family; Region: NMT1_2; cl15260 1114970001249 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114970001250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970001251 dimer interface [polypeptide binding]; other site 1114970001252 conserved gate region; other site 1114970001253 putative PBP binding loops; other site 1114970001254 ABC-ATPase subunit interface; other site 1114970001255 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970001256 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 1114970001257 Walker A/P-loop; other site 1114970001258 ATP binding site [chemical binding]; other site 1114970001259 Q-loop/lid; other site 1114970001260 ABC transporter signature motif; other site 1114970001261 Walker B; other site 1114970001262 D-loop; other site 1114970001263 H-loop/switch region; other site 1114970001264 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1114970001265 active sites [active] 1114970001266 tetramer interface [polypeptide binding]; other site 1114970001267 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1114970001268 active sites [active] 1114970001269 tetramer interface [polypeptide binding]; other site 1114970001270 imidazolonepropionase; Validated; Region: PRK09356 1114970001271 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1114970001272 active site 1114970001273 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1114970001274 NMT1-like family; Region: NMT1_2; cl15260 1114970001275 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1114970001276 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970001277 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114970001278 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1114970001279 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970001280 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1114970001281 putative active site [active] 1114970001282 dimerization interface [polypeptide binding]; other site 1114970001283 putative tRNAtyr binding site [nucleotide binding]; other site 1114970001284 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1114970001285 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1114970001286 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 1114970001287 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1114970001288 Ligand binding site; other site 1114970001289 DXD motif; other site 1114970001290 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 1114970001291 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970001292 dimerization interface [polypeptide binding]; other site 1114970001293 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970001294 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970001295 dimer interface [polypeptide binding]; other site 1114970001296 putative CheW interface [polypeptide binding]; other site 1114970001297 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970001298 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1114970001299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970001300 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970001301 dimer interface [polypeptide binding]; other site 1114970001302 putative CheW interface [polypeptide binding]; other site 1114970001303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 1114970001304 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1114970001305 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1114970001306 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1114970001307 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1114970001308 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1114970001309 metal binding site [ion binding]; metal-binding site 1114970001310 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 1114970001311 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970001312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1114970001313 SCP-2 sterol transfer family; Region: SCP2; cl01225 1114970001314 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1114970001315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970001316 S-adenosylmethionine binding site [chemical binding]; other site 1114970001317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970001318 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 1114970001319 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 1114970001320 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 1114970001321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970001322 Helix-turn-helix domains; Region: HTH; cl00088 1114970001323 Bacterial transcriptional repressor; Region: TetR; pfam13972 1114970001324 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1114970001325 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1114970001326 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 1114970001327 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970001328 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1114970001329 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1114970001330 Protein of unknown function (DUF971); Region: DUF971; cl01414 1114970001331 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1114970001332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970001333 Walker A motif; other site 1114970001334 ATP binding site [chemical binding]; other site 1114970001335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970001336 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1114970001337 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1114970001338 active site 1114970001339 HslU subunit interaction site [polypeptide binding]; other site 1114970001340 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 1114970001341 Sporulation related domain; Region: SPOR; cl10051 1114970001342 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 1114970001343 arginine-tRNA ligase; Region: PLN02286 1114970001344 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1114970001345 active site 1114970001346 HIGH motif; other site 1114970001347 KMSK motif region; other site 1114970001348 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1114970001349 tRNA binding surface [nucleotide binding]; other site 1114970001350 anticodon binding site; other site 1114970001351 primosome assembly protein PriA; Validated; Region: PRK05580 1114970001352 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970001353 ATP binding site [chemical binding]; other site 1114970001354 putative Mg++ binding site [ion binding]; other site 1114970001355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970001356 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1114970001357 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1114970001358 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114970001359 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1114970001360 putative NAD(P) binding site [chemical binding]; other site 1114970001361 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1114970001362 Transglycosylase; Region: Transgly; cl07896 1114970001363 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970001364 Competence protein A; Region: Competence_A; pfam11104 1114970001365 Cell division protein FtsA; Region: FtsA; cl11496 1114970001366 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1114970001367 Pilus assembly protein, PilO; Region: PilO; cl01234 1114970001368 Pilus assembly protein, PilP; Region: PilP; pfam04351 1114970001369 AMIN domain; Region: AMIN; pfam11741 1114970001370 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1114970001371 Secretin and TonB N terminus short domain; Region: STN; cl06624 1114970001372 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970001373 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970001374 shikimate kinase; Reviewed; Region: aroK; PRK00131 1114970001375 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1114970001376 ADP binding site [chemical binding]; other site 1114970001377 magnesium binding site [ion binding]; other site 1114970001378 putative shikimate binding site; other site 1114970001379 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1114970001380 active site 1114970001381 dimer interface [polypeptide binding]; other site 1114970001382 metal binding site [ion binding]; metal-binding site 1114970001383 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1114970001384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1114970001385 Sporulation related domain; Region: SPOR; cl10051 1114970001386 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1114970001387 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1114970001388 active site 1114970001389 dimer interface [polypeptide binding]; other site 1114970001390 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1114970001391 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1114970001392 active site 1114970001393 FMN binding site [chemical binding]; other site 1114970001394 substrate binding site [chemical binding]; other site 1114970001395 3Fe-4S cluster binding site [ion binding]; other site 1114970001396 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1114970001397 domain interface; other site 1114970001398 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1114970001399 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114970001400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970001401 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1114970001402 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1114970001403 substrate binding site [chemical binding]; other site 1114970001404 active site 1114970001405 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 1114970001406 Chitin binding domain; Region: Chitin_bind_3; cl03871 1114970001407 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1114970001408 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 1114970001409 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1114970001410 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970001411 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970001412 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970001413 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970001414 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1114970001415 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1114970001416 Walker A motif; other site 1114970001417 ATP binding site [chemical binding]; other site 1114970001418 Walker B motif; other site 1114970001419 type II secretion system protein F; Region: GspF; TIGR02120 1114970001420 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1114970001421 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1114970001422 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1114970001423 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1114970001424 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1114970001425 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1114970001426 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1114970001427 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1114970001428 type II secretion system protein J; Region: gspJ; TIGR01711 1114970001429 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1114970001430 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1114970001431 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1114970001432 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1114970001433 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1114970001434 GspL periplasmic domain; Region: GspL_C; cl14909 1114970001435 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 1114970001436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970001437 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970001438 putative substrate translocation pore; other site 1114970001439 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1114970001440 Helix-turn-helix domains; Region: HTH; cl00088 1114970001441 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1114970001442 dimerization interface [polypeptide binding]; other site 1114970001443 substrate binding pocket [chemical binding]; other site 1114970001444 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970001445 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970001446 PAAR motif; Region: PAAR_motif; cl15808 1114970001447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970001448 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970001449 putative substrate translocation pore; other site 1114970001450 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114970001451 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1114970001452 substrate binding pocket [chemical binding]; other site 1114970001453 active site 1114970001454 iron coordination sites [ion binding]; other site 1114970001455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970001456 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1114970001457 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1114970001458 Ligand Binding Site [chemical binding]; other site 1114970001459 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1114970001460 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114970001461 dimer interface [polypeptide binding]; other site 1114970001462 active site 1114970001463 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970001464 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1114970001465 NAD(P) binding site [chemical binding]; other site 1114970001466 homotetramer interface [polypeptide binding]; other site 1114970001467 homodimer interface [polypeptide binding]; other site 1114970001468 active site 1114970001469 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1114970001470 putative active site 1 [active] 1114970001471 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1114970001472 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114970001473 dimer interface [polypeptide binding]; other site 1114970001474 active site 1114970001475 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114970001476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970001477 S-adenosylmethionine binding site [chemical binding]; other site 1114970001478 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1114970001479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970001480 Predicted exporter [General function prediction only]; Region: COG4258 1114970001481 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 1114970001482 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114970001483 active site 1114970001484 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1114970001485 active sites [active] 1114970001486 tetramer interface [polypeptide binding]; other site 1114970001487 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1114970001488 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1114970001489 putative acyl-acceptor binding pocket; other site 1114970001490 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1114970001491 Ligand binding site; other site 1114970001492 Putative Catalytic site; other site 1114970001493 DXD motif; other site 1114970001494 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970001495 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 1114970001496 active site 2 [active] 1114970001497 dimer interface [polypeptide binding]; other site 1114970001498 active site 1 [active] 1114970001499 Predicted membrane protein [Function unknown]; Region: COG4648 1114970001500 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970001501 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970001502 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114970001503 putative acyl-acceptor binding pocket; other site 1114970001504 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1114970001505 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114970001506 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114970001507 P-loop; other site 1114970001508 Magnesium ion binding site [ion binding]; other site 1114970001509 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114970001510 Magnesium ion binding site [ion binding]; other site 1114970001511 thioredoxin 2; Provisional; Region: PRK10996 1114970001512 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114970001513 catalytic residues [active] 1114970001514 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970001515 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1114970001516 catalytic triad [active] 1114970001517 dimer interface [polypeptide binding]; other site 1114970001518 conserved cis-peptide bond; other site 1114970001519 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970001520 Helix-turn-helix domains; Region: HTH; cl00088 1114970001521 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1114970001522 putative effector binding pocket; other site 1114970001523 putative dimerization interface [polypeptide binding]; other site 1114970001524 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 1114970001525 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1114970001526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970001527 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 1114970001528 hypothetical protein; Provisional; Region: PRK11281 1114970001529 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1114970001530 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114970001531 potassium/proton antiporter; Reviewed; Region: PRK05326 1114970001532 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1114970001533 Transporter associated domain; Region: CorC_HlyC; cl08393 1114970001534 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970001535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970001536 dimerization interface [polypeptide binding]; other site 1114970001537 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970001538 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970001539 dimer interface [polypeptide binding]; other site 1114970001540 putative CheW interface [polypeptide binding]; other site 1114970001541 Cell division protein ZapA; Region: ZapA; cl01146 1114970001542 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1114970001543 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1114970001544 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970001545 active site 1114970001546 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1114970001547 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1114970001548 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 1114970001549 Proline dehydrogenase; Region: Pro_dh; cl03282 1114970001550 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1114970001551 Glutamate binding site [chemical binding]; other site 1114970001552 NAD binding site [chemical binding]; other site 1114970001553 catalytic residues [active] 1114970001554 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1114970001555 Na binding site [ion binding]; other site 1114970001556 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 1114970001557 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1114970001558 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1114970001559 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970001560 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1114970001561 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1114970001562 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1114970001563 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1114970001564 GAF domain; Region: GAF; cl15785 1114970001565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970001566 PAS domain; Region: PAS_9; pfam13426 1114970001567 putative active site [active] 1114970001568 heme pocket [chemical binding]; other site 1114970001569 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970001570 metal binding site [ion binding]; metal-binding site 1114970001571 active site 1114970001572 I-site; other site 1114970001573 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970001574 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1114970001575 putative active site [active] 1114970001576 putative metal binding site [ion binding]; other site 1114970001577 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1114970001578 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114970001579 E3 interaction surface; other site 1114970001580 lipoyl attachment site [posttranslational modification]; other site 1114970001581 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114970001582 E3 interaction surface; other site 1114970001583 lipoyl attachment site [posttranslational modification]; other site 1114970001584 e3 binding domain; Region: E3_binding; pfam02817 1114970001585 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1114970001586 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1114970001587 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1114970001588 dimer interface [polypeptide binding]; other site 1114970001589 TPP-binding site [chemical binding]; other site 1114970001590 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1114970001591 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1114970001592 metal binding triad; other site 1114970001593 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1114970001594 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1114970001595 metal binding triad; other site 1114970001596 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1114970001597 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1114970001598 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1114970001599 putative active site [active] 1114970001600 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1114970001601 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1114970001602 putative active site [active] 1114970001603 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970001604 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1114970001605 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970001606 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970001607 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970001608 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970001609 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1114970001610 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1114970001611 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1114970001612 putative ADP-binding pocket [chemical binding]; other site 1114970001613 Mig-14; Region: Mig-14; pfam07395 1114970001614 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970001615 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1114970001616 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970001617 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1114970001618 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1114970001619 active site 1114970001620 substrate binding site [chemical binding]; other site 1114970001621 ATP binding site [chemical binding]; other site 1114970001622 O-Antigen ligase; Region: Wzy_C; cl04850 1114970001623 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1114970001624 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114970001625 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1114970001626 Walker A/P-loop; other site 1114970001627 ATP binding site [chemical binding]; other site 1114970001628 Q-loop/lid; other site 1114970001629 ABC transporter signature motif; other site 1114970001630 Walker B; other site 1114970001631 D-loop; other site 1114970001632 H-loop/switch region; other site 1114970001633 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1114970001634 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 1114970001635 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 1114970001636 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 1114970001637 ligand-binding site [chemical binding]; other site 1114970001638 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1114970001639 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1114970001640 putative ribose interaction site [chemical binding]; other site 1114970001641 putative ADP binding site [chemical binding]; other site 1114970001642 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114970001643 active site 1114970001644 nucleotide binding site [chemical binding]; other site 1114970001645 HIGH motif; other site 1114970001646 KMSKS motif; other site 1114970001647 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1114970001648 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970001649 active site 1114970001650 catalytic tetrad [active] 1114970001651 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1114970001652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970001653 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114970001654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970001655 Helix-turn-helix domains; Region: HTH; cl00088 1114970001656 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970001657 dimerization interface [polypeptide binding]; other site 1114970001658 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1114970001659 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1114970001660 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970001661 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1114970001662 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1114970001663 ThiC-associated domain; Region: ThiC-associated; pfam13667 1114970001664 ThiC family; Region: ThiC; cl08031 1114970001665 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114970001666 Na binding site [ion binding]; other site 1114970001667 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1114970001668 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1114970001669 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1114970001670 dimer interface [polypeptide binding]; other site 1114970001671 ADP-ribose binding site [chemical binding]; other site 1114970001672 active site 1114970001673 nudix motif; other site 1114970001674 metal binding site [ion binding]; metal-binding site 1114970001675 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 1114970001676 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1114970001677 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114970001678 active site 1114970001679 metal binding site [ion binding]; metal-binding site 1114970001680 hexamer interface [polypeptide binding]; other site 1114970001681 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1114970001682 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1114970001683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970001684 ATP binding site [chemical binding]; other site 1114970001685 Mg2+ binding site [ion binding]; other site 1114970001686 G-X-G motif; other site 1114970001687 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1114970001688 anchoring element; other site 1114970001689 dimer interface [polypeptide binding]; other site 1114970001690 ATP binding site [chemical binding]; other site 1114970001691 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1114970001692 active site 1114970001693 metal binding site [ion binding]; metal-binding site 1114970001694 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1114970001695 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1114970001696 catalytic motif [active] 1114970001697 Catalytic residue [active] 1114970001698 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1114970001699 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1114970001700 CAP-like domain; other site 1114970001701 active site 1114970001702 primary dimer interface [polypeptide binding]; other site 1114970001703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1114970001704 Protein of unknown function (DUF330); Region: DUF330; cl01135 1114970001705 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 1114970001706 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1114970001707 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1114970001708 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1114970001709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970001710 motif II; other site 1114970001711 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1114970001712 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1114970001713 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1114970001714 active site residue [active] 1114970001715 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1114970001716 active site residue [active] 1114970001717 HDOD domain; Region: HDOD; pfam08668 1114970001718 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1114970001719 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114970001720 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1114970001721 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1114970001722 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970001723 ligand binding site [chemical binding]; other site 1114970001724 GTPase RsgA; Reviewed; Region: PRK12288 1114970001725 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114970001726 RNA binding site [nucleotide binding]; other site 1114970001727 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1114970001728 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1114970001729 GTP/Mg2+ binding site [chemical binding]; other site 1114970001730 G4 box; other site 1114970001731 G5 box; other site 1114970001732 G1 box; other site 1114970001733 Switch I region; other site 1114970001734 G2 box; other site 1114970001735 G3 box; other site 1114970001736 Switch II region; other site 1114970001737 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1114970001738 catalytic site [active] 1114970001739 putative active site [active] 1114970001740 putative substrate binding site [chemical binding]; other site 1114970001741 dimer interface [polypeptide binding]; other site 1114970001742 Predicted membrane protein [Function unknown]; Region: COG2860 1114970001743 UPF0126 domain; Region: UPF0126; pfam03458 1114970001744 UPF0126 domain; Region: UPF0126; pfam03458 1114970001745 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 1114970001746 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1114970001747 putative carbohydrate kinase; Provisional; Region: PRK10565 1114970001748 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1114970001749 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1114970001750 putative substrate binding site [chemical binding]; other site 1114970001751 putative ATP binding site [chemical binding]; other site 1114970001752 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1114970001753 AMIN domain; Region: AMIN; pfam11741 1114970001754 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1114970001755 active site 1114970001756 metal binding site [ion binding]; metal-binding site 1114970001757 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114970001758 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1114970001759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970001760 ATP binding site [chemical binding]; other site 1114970001761 Mg2+ binding site [ion binding]; other site 1114970001762 G-X-G motif; other site 1114970001763 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1114970001764 ATP binding site [chemical binding]; other site 1114970001765 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 1114970001766 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970001767 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1114970001768 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 1114970001769 Sm1 motif; other site 1114970001770 D1 - D2 interaction site; other site 1114970001771 D3 - B interaction site; other site 1114970001772 Hfq - Hfq interaction site; other site 1114970001773 RNA binding pocket [nucleotide binding]; other site 1114970001774 Sm2 motif; other site 1114970001775 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1114970001776 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1114970001777 HflX GTPase family; Region: HflX; cd01878 1114970001778 G1 box; other site 1114970001779 GTP/Mg2+ binding site [chemical binding]; other site 1114970001780 Switch I region; other site 1114970001781 G2 box; other site 1114970001782 G3 box; other site 1114970001783 Switch II region; other site 1114970001784 G4 box; other site 1114970001785 G5 box; other site 1114970001786 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1114970001787 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1114970001788 HflK protein; Region: hflK; TIGR01933 1114970001789 FtsH protease regulator HflC; Provisional; Region: PRK11029 1114970001790 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1114970001791 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1114970001792 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1114970001793 dimer interface [polypeptide binding]; other site 1114970001794 motif 1; other site 1114970001795 active site 1114970001796 motif 2; other site 1114970001797 motif 3; other site 1114970001798 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1114970001799 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1114970001800 GDP-binding site [chemical binding]; other site 1114970001801 ACT binding site; other site 1114970001802 IMP binding site; other site 1114970001803 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970001804 dimerization interface [polypeptide binding]; other site 1114970001805 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970001806 dimer interface [polypeptide binding]; other site 1114970001807 putative CheW interface [polypeptide binding]; other site 1114970001808 ribonuclease R; Region: RNase_R; TIGR02063 1114970001809 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114970001810 RNB domain; Region: RNB; pfam00773 1114970001811 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 1114970001812 RNA binding site [nucleotide binding]; other site 1114970001813 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1114970001814 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1114970001815 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1114970001816 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 1114970001817 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 1114970001818 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1114970001819 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1114970001820 replicative DNA helicase; Provisional; Region: PRK05748 1114970001821 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1114970001822 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1114970001823 Walker A motif; other site 1114970001824 ATP binding site [chemical binding]; other site 1114970001825 Walker B motif; other site 1114970001826 DNA binding loops [nucleotide binding] 1114970001827 hypothetical protein; Provisional; Region: PRK01254 1114970001828 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1114970001829 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1114970001830 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1114970001831 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1114970001832 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1114970001833 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1114970001834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1114970001835 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1114970001836 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 1114970001837 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 1114970001838 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1114970001839 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1114970001840 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1114970001841 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114970001842 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1114970001843 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1114970001844 homodimer interface [polypeptide binding]; other site 1114970001845 NAD binding pocket [chemical binding]; other site 1114970001846 ATP binding pocket [chemical binding]; other site 1114970001847 Mg binding site [ion binding]; other site 1114970001848 active-site loop [active] 1114970001849 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1114970001850 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1114970001851 active site 1114970001852 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970001853 Helix-turn-helix domains; Region: HTH; cl00088 1114970001854 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1114970001855 dimerization interface [polypeptide binding]; other site 1114970001856 substrate binding pocket [chemical binding]; other site 1114970001857 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1114970001858 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970001859 tetrameric interface [polypeptide binding]; other site 1114970001860 NAD binding site [chemical binding]; other site 1114970001861 catalytic residues [active] 1114970001862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970001863 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970001864 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 1114970001865 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1114970001866 dimerization interface [polypeptide binding]; other site 1114970001867 ligand binding site [chemical binding]; other site 1114970001868 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1114970001869 TM-ABC transporter signature motif; other site 1114970001870 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1114970001871 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1114970001872 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1114970001873 TM-ABC transporter signature motif; other site 1114970001874 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1114970001875 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 1114970001876 Walker A/P-loop; other site 1114970001877 ATP binding site [chemical binding]; other site 1114970001878 Q-loop/lid; other site 1114970001879 ABC transporter signature motif; other site 1114970001880 Walker B; other site 1114970001881 D-loop; other site 1114970001882 H-loop/switch region; other site 1114970001883 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1114970001884 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 1114970001885 Walker A/P-loop; other site 1114970001886 ATP binding site [chemical binding]; other site 1114970001887 Q-loop/lid; other site 1114970001888 ABC transporter signature motif; other site 1114970001889 Walker B; other site 1114970001890 D-loop; other site 1114970001891 H-loop/switch region; other site 1114970001892 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1114970001893 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1114970001894 putative NAD(P) binding site [chemical binding]; other site 1114970001895 homotetramer interface [polypeptide binding]; other site 1114970001896 homodimer interface [polypeptide binding]; other site 1114970001897 active site 1114970001898 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1114970001899 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 1114970001900 dimerization interface [polypeptide binding]; other site 1114970001901 putative active cleft [active] 1114970001902 HupE / UreJ protein; Region: HupE_UreJ; cl01011 1114970001903 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970001904 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1114970001905 UreF; Region: UreF; pfam01730 1114970001906 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1114970001907 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1114970001908 dimer interface [polypeptide binding]; other site 1114970001909 catalytic residues [active] 1114970001910 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1114970001911 Helix-turn-helix domains; Region: HTH; cl00088 1114970001912 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1114970001913 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1114970001914 AsmA-like C-terminal region; Region: AsmA_2; cl15864 1114970001915 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1114970001916 Ferritin-like domain; Region: Ferritin; pfam00210 1114970001917 dinuclear metal binding motif [ion binding]; other site 1114970001918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970001919 Helix-turn-helix domains; Region: HTH; cl00088 1114970001920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970001921 dimerization interface [polypeptide binding]; other site 1114970001922 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970001923 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1114970001924 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970001925 hypothetical protein; Provisional; Region: PRK11505 1114970001926 psiF repeat; Region: PsiF_repeat; pfam07769 1114970001927 psiF repeat; Region: PsiF_repeat; pfam07769 1114970001928 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114970001929 putative chaperone; Provisional; Region: PRK11678 1114970001930 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1114970001931 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114970001932 HSP70 interaction site [polypeptide binding]; other site 1114970001933 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1114970001934 substrate binding site [polypeptide binding]; other site 1114970001935 dimer interface [polypeptide binding]; other site 1114970001936 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1114970001937 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1114970001938 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 1114970001939 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1114970001940 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1114970001941 subunit interactions [polypeptide binding]; other site 1114970001942 active site 1114970001943 flap region; other site 1114970001944 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1114970001945 gamma-beta subunit interface [polypeptide binding]; other site 1114970001946 alpha-beta subunit interface [polypeptide binding]; other site 1114970001947 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970001948 Coenzyme A binding pocket [chemical binding]; other site 1114970001949 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1114970001950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970001951 Coenzyme A binding pocket [chemical binding]; other site 1114970001952 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1114970001953 alpha-gamma subunit interface [polypeptide binding]; other site 1114970001954 beta-gamma subunit interface [polypeptide binding]; other site 1114970001955 UreD urease accessory protein; Region: UreD; cl00530 1114970001956 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1114970001957 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 1114970001958 Walker A/P-loop; other site 1114970001959 ATP binding site [chemical binding]; other site 1114970001960 Q-loop/lid; other site 1114970001961 ABC transporter signature motif; other site 1114970001962 Walker B; other site 1114970001963 D-loop; other site 1114970001964 H-loop/switch region; other site 1114970001965 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1114970001966 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 1114970001967 Walker A/P-loop; other site 1114970001968 ATP binding site [chemical binding]; other site 1114970001969 Q-loop/lid; other site 1114970001970 ABC transporter signature motif; other site 1114970001971 Walker B; other site 1114970001972 D-loop; other site 1114970001973 H-loop/switch region; other site 1114970001974 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1114970001975 TM-ABC transporter signature motif; other site 1114970001976 HEAT repeats; Region: HEAT_2; pfam13646 1114970001977 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1114970001978 TM-ABC transporter signature motif; other site 1114970001979 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1114970001980 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1114970001981 putative ligand binding site [chemical binding]; other site 1114970001982 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114970001983 ABC-ATPase subunit interface; other site 1114970001984 dimer interface [polypeptide binding]; other site 1114970001985 putative PBP binding regions; other site 1114970001986 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1114970001987 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1114970001988 putative ligand binding residues [chemical binding]; other site 1114970001989 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114970001990 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114970001991 Walker A/P-loop; other site 1114970001992 ATP binding site [chemical binding]; other site 1114970001993 Q-loop/lid; other site 1114970001994 ABC transporter signature motif; other site 1114970001995 Walker B; other site 1114970001996 D-loop; other site 1114970001997 H-loop/switch region; other site 1114970001998 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1114970001999 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1114970002000 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1114970002001 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970002002 N-terminal plug; other site 1114970002003 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1114970002004 ligand-binding site [chemical binding]; other site 1114970002005 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1114970002006 Protein of unknown function (DUF461); Region: DUF461; cl01071 1114970002007 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1114970002008 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970002009 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1114970002010 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1114970002011 CbiD; Region: CbiD; cl00828 1114970002012 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1114970002013 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1114970002014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970002015 S-adenosylmethionine binding site [chemical binding]; other site 1114970002016 precorrin-3B synthase; Region: CobG; TIGR02435 1114970002017 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114970002018 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 1114970002019 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1114970002020 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1114970002021 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1114970002022 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1114970002023 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1114970002024 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 1114970002025 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1114970002026 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1114970002027 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 1114970002028 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 1114970002029 MarC family integral membrane protein; Region: MarC; cl00919 1114970002030 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1114970002031 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1114970002032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970002033 dimer interface [polypeptide binding]; other site 1114970002034 phosphorylation site [posttranslational modification] 1114970002035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970002036 ATP binding site [chemical binding]; other site 1114970002037 Mg2+ binding site [ion binding]; other site 1114970002038 G-X-G motif; other site 1114970002039 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970002040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970002041 active site 1114970002042 phosphorylation site [posttranslational modification] 1114970002043 intermolecular recognition site; other site 1114970002044 dimerization interface [polypeptide binding]; other site 1114970002045 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970002046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970002047 active site 1114970002048 phosphorylation site [posttranslational modification] 1114970002049 intermolecular recognition site; other site 1114970002050 dimerization interface [polypeptide binding]; other site 1114970002051 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1114970002052 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1114970002053 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970002054 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1114970002055 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1114970002056 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1114970002057 purine monophosphate binding site [chemical binding]; other site 1114970002058 dimer interface [polypeptide binding]; other site 1114970002059 putative catalytic residues [active] 1114970002060 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1114970002061 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1114970002062 Helix-turn-helix domains; Region: HTH; cl00088 1114970002063 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1114970002064 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1114970002065 FMN binding site [chemical binding]; other site 1114970002066 active site 1114970002067 catalytic residues [active] 1114970002068 substrate binding site [chemical binding]; other site 1114970002069 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1114970002070 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1114970002071 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1114970002072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970002073 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1114970002074 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970002075 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970002076 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1114970002077 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1114970002078 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970002079 carboxyltransferase (CT) interaction site; other site 1114970002080 biotinylation site [posttranslational modification]; other site 1114970002081 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1114970002082 active site 1114970002083 trimer interface [polypeptide binding]; other site 1114970002084 dimer interface [polypeptide binding]; other site 1114970002085 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970002086 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970002087 dimer interface [polypeptide binding]; other site 1114970002088 putative CheW interface [polypeptide binding]; other site 1114970002089 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1114970002090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970002091 active site 1114970002092 phosphorylation site [posttranslational modification] 1114970002093 intermolecular recognition site; other site 1114970002094 dimerization interface [polypeptide binding]; other site 1114970002095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970002096 metal binding site [ion binding]; metal-binding site 1114970002097 active site 1114970002098 I-site; other site 1114970002099 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 1114970002100 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1114970002101 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1114970002102 nudix motif; other site 1114970002103 translation initiation factor Sui1; Validated; Region: PRK06824 1114970002104 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1114970002105 putative rRNA binding site [nucleotide binding]; other site 1114970002106 arginine decarboxylase; Provisional; Region: PRK05354 1114970002107 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1114970002108 dimer interface [polypeptide binding]; other site 1114970002109 active site 1114970002110 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970002111 catalytic residues [active] 1114970002112 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1114970002113 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1114970002114 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970002115 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1114970002116 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1114970002117 MatE; Region: MatE; cl10513 1114970002118 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1114970002119 homodimer interface [polypeptide binding]; other site 1114970002120 chemical substrate binding site [chemical binding]; other site 1114970002121 oligomer interface [polypeptide binding]; other site 1114970002122 metal binding site [ion binding]; metal-binding site 1114970002123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970002124 S-adenosylmethionine binding site [chemical binding]; other site 1114970002125 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1114970002126 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1114970002127 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1114970002128 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1114970002129 active site 2 [active] 1114970002130 active site 1 [active] 1114970002131 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1114970002132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970002133 NAD(P) binding site [chemical binding]; other site 1114970002134 active site 1114970002135 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1114970002136 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970002137 dimer interface [polypeptide binding]; other site 1114970002138 active site 1114970002139 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1114970002140 Membrane transport protein; Region: Mem_trans; cl09117 1114970002141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970002142 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970002143 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 1114970002144 ATP binding site [chemical binding]; other site 1114970002145 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1114970002146 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1114970002147 DNA binding residues [nucleotide binding] 1114970002148 dimer interface [polypeptide binding]; other site 1114970002149 copper binding site [ion binding]; other site 1114970002150 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114970002151 metal-binding site [ion binding] 1114970002152 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114970002153 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114970002154 metal-binding site [ion binding] 1114970002155 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114970002156 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114970002157 metal-binding site [ion binding] 1114970002158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970002159 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1114970002160 putative substrate translocation pore; other site 1114970002161 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1114970002162 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1114970002163 putative NAD(P) binding site [chemical binding]; other site 1114970002164 dimer interface [polypeptide binding]; other site 1114970002165 Helix-turn-helix domains; Region: HTH; cl00088 1114970002166 transcriptional activator TtdR; Provisional; Region: PRK09801 1114970002167 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970002168 putative effector binding pocket; other site 1114970002169 dimerization interface [polypeptide binding]; other site 1114970002170 Helix-turn-helix domains; Region: HTH; cl00088 1114970002171 benzoate transport; Region: 2A0115; TIGR00895 1114970002172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970002173 putative substrate translocation pore; other site 1114970002174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970002175 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1114970002176 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1114970002177 active site 1114970002178 purine riboside binding site [chemical binding]; other site 1114970002179 oxidase reductase; Provisional; Region: PTZ00273 1114970002180 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 1114970002181 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1114970002182 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1114970002183 putative ligand binding site [chemical binding]; other site 1114970002184 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1114970002185 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1114970002186 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1114970002187 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1114970002188 active site 1114970002189 putative substrate binding pocket [chemical binding]; other site 1114970002190 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1114970002191 NADP binding site [chemical binding]; other site 1114970002192 homodimer interface [polypeptide binding]; other site 1114970002193 active site 1114970002194 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1114970002195 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1114970002196 DNA binding residues [nucleotide binding] 1114970002197 dimer interface [polypeptide binding]; other site 1114970002198 metal binding site [ion binding]; metal-binding site 1114970002199 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1114970002200 TM-ABC transporter signature motif; other site 1114970002201 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1114970002202 TM-ABC transporter signature motif; other site 1114970002203 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1114970002204 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 1114970002205 Walker A/P-loop; other site 1114970002206 ATP binding site [chemical binding]; other site 1114970002207 Q-loop/lid; other site 1114970002208 ABC transporter signature motif; other site 1114970002209 Walker B; other site 1114970002210 D-loop; other site 1114970002211 H-loop/switch region; other site 1114970002212 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1114970002213 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1114970002214 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1114970002215 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1114970002216 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1114970002217 Helix-turn-helix domains; Region: HTH; cl00088 1114970002218 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1114970002219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970002220 Helix-turn-helix domains; Region: HTH; cl00088 1114970002221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970002222 dimerization interface [polypeptide binding]; other site 1114970002223 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1114970002224 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970002225 inhibitor-cofactor binding pocket; inhibition site 1114970002226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970002227 catalytic residue [active] 1114970002228 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1114970002229 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970002230 tetrameric interface [polypeptide binding]; other site 1114970002231 NAD binding site [chemical binding]; other site 1114970002232 catalytic residues [active] 1114970002233 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1114970002234 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1114970002235 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970002236 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1114970002237 Family description; Region: UvrD_C_2; cl15862 1114970002238 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1114970002239 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1114970002240 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970002241 Family description; Region: UvrD_C_2; cl15862 1114970002242 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1114970002243 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1114970002244 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970002245 metal binding site [ion binding]; metal-binding site 1114970002246 active site 1114970002247 I-site; other site 1114970002248 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970002249 ligand binding site [chemical binding]; other site 1114970002250 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970002251 Helix-turn-helix domains; Region: HTH; cl00088 1114970002252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970002253 dimerization interface [polypeptide binding]; other site 1114970002254 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1114970002255 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970002256 tetrameric interface [polypeptide binding]; other site 1114970002257 NAD binding site [chemical binding]; other site 1114970002258 catalytic residues [active] 1114970002259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970002260 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1114970002261 Cupin domain; Region: Cupin_2; cl09118 1114970002262 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970002263 Helix-turn-helix domains; Region: HTH; cl00088 1114970002264 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1114970002265 putative dimerization interface [polypeptide binding]; other site 1114970002266 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114970002267 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970002268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970002269 Helix-turn-helix domains; Region: HTH; cl00088 1114970002270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970002271 dimerization interface [polypeptide binding]; other site 1114970002272 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1114970002273 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114970002274 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114970002275 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1114970002276 GntP family permease; Region: GntP_permease; pfam02447 1114970002277 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1114970002278 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114970002279 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114970002280 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114970002281 putative active site [active] 1114970002282 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1114970002283 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1114970002284 active site 1114970002285 putative substrate binding pocket [chemical binding]; other site 1114970002286 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1114970002287 dimer interface [polypeptide binding]; other site 1114970002288 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970002289 ligand binding site [chemical binding]; other site 1114970002290 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970002291 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970002292 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 1114970002293 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1114970002294 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1114970002295 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 1114970002296 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; cl04143 1114970002297 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970002298 dimerization interface [polypeptide binding]; other site 1114970002299 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970002300 dimer interface [polypeptide binding]; other site 1114970002301 putative CheW interface [polypeptide binding]; other site 1114970002302 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1114970002303 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1114970002304 active site 1114970002305 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970002306 ligand binding site [chemical binding]; other site 1114970002307 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1114970002308 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114970002309 flagellin; Validated; Region: PRK06819 1114970002310 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1114970002311 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1114970002312 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1114970002313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970002314 binding surface 1114970002315 TPR motif; other site 1114970002316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970002317 TPR motif; other site 1114970002318 binding surface 1114970002319 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970002320 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1114970002321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970002322 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114970002323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970002324 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1114970002325 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970002326 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114970002327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970002328 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 1114970002329 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970002330 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 1114970002331 FHIPEP family; Region: FHIPEP; pfam00771 1114970002332 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1114970002333 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1114970002334 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1114970002335 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1114970002336 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970002337 ligand binding site [chemical binding]; other site 1114970002338 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114970002339 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036 1114970002340 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 1114970002341 Flagellar protein FliT; Region: FliT; cl05125 1114970002342 Flagellar protein FliS; Region: FliS; cl00654 1114970002343 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1114970002344 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1114970002345 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1114970002346 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1114970002347 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1114970002348 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1114970002349 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1114970002350 FliG C-terminal domain; Region: FliG_C; pfam01706 1114970002351 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1114970002352 Flagellar assembly protein FliH; Region: FliH; pfam02108 1114970002353 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1114970002354 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1114970002355 Walker A motif/ATP binding site; other site 1114970002356 Walker B motif; other site 1114970002357 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 1114970002358 Flagellar FliJ protein; Region: FliJ; pfam02050 1114970002359 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 1114970002360 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1114970002361 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1114970002362 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1114970002363 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1114970002364 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1114970002365 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1114970002366 FliP family; Region: FliP; cl00593 1114970002367 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1114970002368 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1114970002369 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 1114970002370 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1114970002371 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1114970002372 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114970002373 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1114970002374 Rod binding protein; Region: Rod-binding; cl01626 1114970002375 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1114970002376 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1114970002377 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1114970002378 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 1114970002379 Flagellar L-ring protein; Region: FlgH; cl00905 1114970002380 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1114970002381 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1114970002382 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114970002383 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1114970002384 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114970002385 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1114970002386 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1114970002387 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1114970002388 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114970002389 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114970002390 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1114970002391 FlgD Ig-like domain; Region: FlgD_ig; cl15790 1114970002392 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1114970002393 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1114970002394 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114970002395 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1114970002396 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1114970002397 SAF-like; Region: SAF_2; pfam13144 1114970002398 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1114970002399 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 1114970002400 FlgN protein; Region: FlgN; cl09176 1114970002401 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1114970002402 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1114970002403 dimer interface [polypeptide binding]; other site 1114970002404 active site 1114970002405 heme binding site [chemical binding]; other site 1114970002406 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1114970002407 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1114970002408 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1114970002409 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1114970002410 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114970002411 Walker A/P-loop; other site 1114970002412 ATP binding site [chemical binding]; other site 1114970002413 Q-loop/lid; other site 1114970002414 ABC transporter signature motif; other site 1114970002415 Walker B; other site 1114970002416 D-loop; other site 1114970002417 H-loop/switch region; other site 1114970002418 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970002419 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114970002420 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114970002421 Walker A/P-loop; other site 1114970002422 ATP binding site [chemical binding]; other site 1114970002423 Q-loop/lid; other site 1114970002424 ABC transporter signature motif; other site 1114970002425 Walker B; other site 1114970002426 D-loop; other site 1114970002427 H-loop/switch region; other site 1114970002428 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970002429 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1114970002430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002431 dimer interface [polypeptide binding]; other site 1114970002432 conserved gate region; other site 1114970002433 putative PBP binding loops; other site 1114970002434 ABC-ATPase subunit interface; other site 1114970002435 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114970002436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002437 dimer interface [polypeptide binding]; other site 1114970002438 conserved gate region; other site 1114970002439 putative PBP binding loops; other site 1114970002440 ABC-ATPase subunit interface; other site 1114970002441 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1114970002442 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1114970002443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970002444 DNA binding residues [nucleotide binding] 1114970002445 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1114970002446 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970002447 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970002448 Surface antigen; Region: Bac_surface_Ag; cl03097 1114970002449 haemagglutination activity domain; Region: Haemagg_act; cl05436 1114970002450 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1114970002451 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970002452 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970002453 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970002454 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970002455 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970002456 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970002457 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1114970002458 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970002459 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970002460 Integrase core domain; Region: rve; cl01316 1114970002461 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970002462 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970002463 Helix-turn-helix domains; Region: HTH; cl00088 1114970002464 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 1114970002465 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1114970002466 Fic family protein [Function unknown]; Region: COG3177 1114970002467 Fic/DOC family; Region: Fic; cl00960 1114970002468 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114970002469 MULE transposase domain; Region: MULE; pfam10551 1114970002470 short chain dehydrogenase; Provisional; Region: PRK06180 1114970002471 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1114970002472 NADP binding site [chemical binding]; other site 1114970002473 active site 1114970002474 steroid binding site; other site 1114970002475 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1114970002476 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970002477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970002478 2-isopropylmalate synthase; Validated; Region: PRK03739 1114970002479 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1114970002480 active site 1114970002481 catalytic residues [active] 1114970002482 metal binding site [ion binding]; metal-binding site 1114970002483 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1114970002484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970002485 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1114970002486 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970002487 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1114970002488 conserved cys residue [active] 1114970002489 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970002490 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970002491 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970002492 substrate binding pocket [chemical binding]; other site 1114970002493 membrane-bound complex binding site; other site 1114970002494 hinge residues; other site 1114970002495 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970002496 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970002497 Walker A/P-loop; other site 1114970002498 ATP binding site [chemical binding]; other site 1114970002499 Q-loop/lid; other site 1114970002500 ABC transporter signature motif; other site 1114970002501 Walker B; other site 1114970002502 D-loop; other site 1114970002503 H-loop/switch region; other site 1114970002504 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970002505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002506 dimer interface [polypeptide binding]; other site 1114970002507 conserved gate region; other site 1114970002508 putative PBP binding loops; other site 1114970002509 ABC-ATPase subunit interface; other site 1114970002510 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970002511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002512 dimer interface [polypeptide binding]; other site 1114970002513 conserved gate region; other site 1114970002514 putative PBP binding loops; other site 1114970002515 ABC-ATPase subunit interface; other site 1114970002516 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1114970002517 Amidase; Region: Amidase; cl11426 1114970002518 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1114970002519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970002520 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1114970002521 homotrimer interaction site [polypeptide binding]; other site 1114970002522 putative active site [active] 1114970002523 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1114970002524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970002525 Helix-turn-helix domains; Region: HTH; cl00088 1114970002526 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970002527 Helix-turn-helix domains; Region: HTH; cl00088 1114970002528 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970002529 dimerization interface [polypeptide binding]; other site 1114970002530 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970002531 classical (c) SDRs; Region: SDR_c; cd05233 1114970002532 NAD(P) binding site [chemical binding]; other site 1114970002533 active site 1114970002534 hypothetical protein; Provisional; Region: PRK06847 1114970002535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970002536 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1114970002537 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1114970002538 histidinol dehydrogenase; Region: hisD; TIGR00069 1114970002539 NAD binding site [chemical binding]; other site 1114970002540 dimerization interface [polypeptide binding]; other site 1114970002541 product binding site; other site 1114970002542 substrate binding site [chemical binding]; other site 1114970002543 zinc binding site [ion binding]; other site 1114970002544 catalytic residues [active] 1114970002545 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114970002546 classical (c) SDRs; Region: SDR_c; cd05233 1114970002547 NAD(P) binding site [chemical binding]; other site 1114970002548 active site 1114970002549 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970002550 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1114970002551 active site 1114970002552 metal binding site [ion binding]; metal-binding site 1114970002553 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970002554 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970002555 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970002556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970002557 NAD(P) binding site [chemical binding]; other site 1114970002558 active site 1114970002559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970002560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970002561 putative substrate translocation pore; other site 1114970002562 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1114970002563 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114970002564 classical (c) SDRs; Region: SDR_c; cd05233 1114970002565 NAD(P) binding site [chemical binding]; other site 1114970002566 active site 1114970002567 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1114970002568 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 1114970002569 putative active site [active] 1114970002570 putative metal binding site [ion binding]; other site 1114970002571 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 1114970002572 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970002573 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1114970002574 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1114970002575 integrase; Provisional; Region: PRK09692 1114970002576 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1114970002577 active site 1114970002578 Int/Topo IB signature motif; other site 1114970002579 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114970002580 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970002581 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114970002582 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114970002583 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1114970002584 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1114970002585 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1114970002586 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114970002587 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1114970002588 Cysteine-rich domain; Region: CCG; pfam02754 1114970002589 Cysteine-rich domain; Region: CCG; pfam02754 1114970002590 glycolate transporter; Provisional; Region: PRK09695 1114970002591 L-lactate permease; Region: Lactate_perm; cl00701 1114970002592 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970002593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970002594 DNA-binding site [nucleotide binding]; DNA binding site 1114970002595 FCD domain; Region: FCD; cl11656 1114970002596 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1114970002597 SmpB-tmRNA interface; other site 1114970002598 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1114970002599 Na2 binding site [ion binding]; other site 1114970002600 putative substrate binding site 1 [chemical binding]; other site 1114970002601 Na binding site 1 [ion binding]; other site 1114970002602 putative substrate binding site 2 [chemical binding]; other site 1114970002603 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1114970002604 putative coenzyme Q binding site [chemical binding]; other site 1114970002605 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1114970002606 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 1114970002607 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1114970002608 metal binding site 2 [ion binding]; metal-binding site 1114970002609 putative DNA binding helix; other site 1114970002610 metal binding site 1 [ion binding]; metal-binding site 1114970002611 dimer interface [polypeptide binding]; other site 1114970002612 structural Zn2+ binding site [ion binding]; other site 1114970002613 recombination and repair protein; Provisional; Region: PRK10869 1114970002614 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1114970002615 Walker A/P-loop; other site 1114970002616 ATP binding site [chemical binding]; other site 1114970002617 Q-loop/lid; other site 1114970002618 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1114970002619 Q-loop/lid; other site 1114970002620 ABC transporter signature motif; other site 1114970002621 Walker B; other site 1114970002622 D-loop; other site 1114970002623 H-loop/switch region; other site 1114970002624 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1114970002625 dimer interface [polypeptide binding]; other site 1114970002626 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1114970002627 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1114970002628 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1114970002629 chaperone protein DnaJ; Provisional; Region: PRK10767 1114970002630 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114970002631 HSP70 interaction site [polypeptide binding]; other site 1114970002632 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1114970002633 substrate binding site [polypeptide binding]; other site 1114970002634 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1114970002635 Zn binding sites [ion binding]; other site 1114970002636 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1114970002637 dimer interface [polypeptide binding]; other site 1114970002638 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1114970002639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970002640 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1114970002641 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1114970002642 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1114970002643 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1114970002644 catalytic site [active] 1114970002645 subunit interface [polypeptide binding]; other site 1114970002646 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1114970002647 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970002648 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970002649 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1114970002650 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970002651 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970002652 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1114970002653 IMP binding site; other site 1114970002654 dimer interface [polypeptide binding]; other site 1114970002655 interdomain contacts; other site 1114970002656 partial ornithine binding site; other site 1114970002657 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1114970002658 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1114970002659 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114970002660 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 1114970002661 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1114970002662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970002663 S-adenosylmethionine binding site [chemical binding]; other site 1114970002664 FtsH Extracellular; Region: FtsH_ext; pfam06480 1114970002665 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1114970002666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970002667 Walker A motif; other site 1114970002668 ATP binding site [chemical binding]; other site 1114970002669 Walker B motif; other site 1114970002670 arginine finger; other site 1114970002671 Peptidase family M41; Region: Peptidase_M41; pfam01434 1114970002672 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1114970002673 dihydropteroate synthase; Region: DHPS; TIGR01496 1114970002674 substrate binding pocket [chemical binding]; other site 1114970002675 dimer interface [polypeptide binding]; other site 1114970002676 inhibitor binding site; inhibition site 1114970002677 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1114970002678 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1114970002679 active site 1114970002680 substrate binding site [chemical binding]; other site 1114970002681 metal binding site [ion binding]; metal-binding site 1114970002682 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1114970002683 substrate binding site [chemical binding]; other site 1114970002684 dimer interface [polypeptide binding]; other site 1114970002685 catalytic triad [active] 1114970002686 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1114970002687 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 1114970002688 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 1114970002689 Sm1 motif; other site 1114970002690 D1 - D2 interaction site; other site 1114970002691 D3 - B interaction site; other site 1114970002692 Hfq - Hfq interaction site; other site 1114970002693 RNA binding pocket [nucleotide binding]; other site 1114970002694 Sm2 motif; other site 1114970002695 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1114970002696 NusA N-terminal domain; Region: NusA_N; pfam08529 1114970002697 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1114970002698 RNA binding site [nucleotide binding]; other site 1114970002699 homodimer interface [polypeptide binding]; other site 1114970002700 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1114970002701 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1114970002702 G-X-X-G motif; other site 1114970002703 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1114970002704 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1114970002705 translation initiation factor IF-2; Validated; Region: infB; PRK05306 1114970002706 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1114970002707 translation initiation factor IF-2; Region: IF-2; TIGR00487 1114970002708 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1114970002709 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1114970002710 G1 box; other site 1114970002711 putative GEF interaction site [polypeptide binding]; other site 1114970002712 GTP/Mg2+ binding site [chemical binding]; other site 1114970002713 Switch I region; other site 1114970002714 G2 box; other site 1114970002715 G3 box; other site 1114970002716 Switch II region; other site 1114970002717 G4 box; other site 1114970002718 G5 box; other site 1114970002719 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1114970002720 Translation-initiation factor 2; Region: IF-2; pfam11987 1114970002721 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1114970002722 Ribosome-binding factor A; Region: RBFA; cl00542 1114970002723 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1114970002724 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1114970002725 RNA binding site [nucleotide binding]; other site 1114970002726 active site 1114970002727 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1114970002728 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1114970002729 16S/18S rRNA binding site [nucleotide binding]; other site 1114970002730 S13e-L30e interaction site [polypeptide binding]; other site 1114970002731 25S rRNA binding site [nucleotide binding]; other site 1114970002732 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1114970002733 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1114970002734 RNase E interface [polypeptide binding]; other site 1114970002735 trimer interface [polypeptide binding]; other site 1114970002736 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1114970002737 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1114970002738 RNase E interface [polypeptide binding]; other site 1114970002739 trimer interface [polypeptide binding]; other site 1114970002740 active site 1114970002741 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1114970002742 putative nucleic acid binding region [nucleotide binding]; other site 1114970002743 G-X-X-G motif; other site 1114970002744 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1114970002745 RNA binding site [nucleotide binding]; other site 1114970002746 domain interface; other site 1114970002747 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 1114970002748 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 1114970002749 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1114970002750 dimerization interface [polypeptide binding]; other site 1114970002751 active site 1114970002752 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 1114970002753 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114970002754 amidase catalytic site [active] 1114970002755 Zn binding residues [ion binding]; other site 1114970002756 substrate binding site [chemical binding]; other site 1114970002757 CobD/Cbib protein; Region: CobD_Cbib; cl00561 1114970002758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970002759 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970002760 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970002761 dimer interface [polypeptide binding]; other site 1114970002762 putative CheW interface [polypeptide binding]; other site 1114970002763 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1114970002764 active site 1114970002765 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1114970002766 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970002767 DNA binding site [nucleotide binding] 1114970002768 domain linker motif; other site 1114970002769 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1114970002770 dimerization interface [polypeptide binding]; other site 1114970002771 ligand binding site [chemical binding]; other site 1114970002772 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1114970002773 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114970002774 active site 1114970002775 phosphorylation site [posttranslational modification] 1114970002776 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1114970002777 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 1114970002778 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1114970002779 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1114970002780 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1114970002781 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1114970002782 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1114970002783 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1114970002784 putative substrate binding site [chemical binding]; other site 1114970002785 putative ATP binding site [chemical binding]; other site 1114970002786 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1114970002787 active site 1114970002788 P-loop; other site 1114970002789 phosphorylation site [posttranslational modification] 1114970002790 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1114970002791 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1114970002792 active site 1114970002793 P-loop; other site 1114970002794 phosphorylation site [posttranslational modification] 1114970002795 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114970002796 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1114970002797 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1114970002798 putative active site [active] 1114970002799 putative metal binding site [ion binding]; other site 1114970002800 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1114970002801 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1114970002802 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1114970002803 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1114970002804 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1114970002805 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1114970002806 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970002807 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1114970002808 FAD binding pocket [chemical binding]; other site 1114970002809 FAD binding motif [chemical binding]; other site 1114970002810 catalytic residues [active] 1114970002811 NAD binding pocket [chemical binding]; other site 1114970002812 phosphate binding motif [ion binding]; other site 1114970002813 beta-alpha-beta structure motif; other site 1114970002814 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1114970002815 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1114970002816 dimer interface [polypeptide binding]; other site 1114970002817 active site 1114970002818 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970002819 catalytic residues [active] 1114970002820 substrate binding site [chemical binding]; other site 1114970002821 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1114970002822 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 1114970002823 Walker A/P-loop; other site 1114970002824 ATP binding site [chemical binding]; other site 1114970002825 Q-loop/lid; other site 1114970002826 ABC transporter signature motif; other site 1114970002827 Walker B; other site 1114970002828 D-loop; other site 1114970002829 H-loop/switch region; other site 1114970002830 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1114970002831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002832 dimer interface [polypeptide binding]; other site 1114970002833 conserved gate region; other site 1114970002834 ABC-ATPase subunit interface; other site 1114970002835 NMT1-like family; Region: NMT1_2; cl15260 1114970002836 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114970002837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002838 ABC-ATPase subunit interface; other site 1114970002839 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1114970002840 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1114970002841 G1 box; other site 1114970002842 putative GEF interaction site [polypeptide binding]; other site 1114970002843 GTP/Mg2+ binding site [chemical binding]; other site 1114970002844 Switch I region; other site 1114970002845 G2 box; other site 1114970002846 G3 box; other site 1114970002847 Switch II region; other site 1114970002848 G4 box; other site 1114970002849 G5 box; other site 1114970002850 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1114970002851 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1114970002852 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114970002853 Walker A/P-loop; other site 1114970002854 ATP binding site [chemical binding]; other site 1114970002855 Q-loop/lid; other site 1114970002856 ABC transporter signature motif; other site 1114970002857 Walker B; other site 1114970002858 D-loop; other site 1114970002859 H-loop/switch region; other site 1114970002860 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970002861 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1114970002862 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114970002863 Walker A/P-loop; other site 1114970002864 ATP binding site [chemical binding]; other site 1114970002865 Q-loop/lid; other site 1114970002866 ABC transporter signature motif; other site 1114970002867 Walker B; other site 1114970002868 D-loop; other site 1114970002869 H-loop/switch region; other site 1114970002870 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970002871 dipeptide transporter; Provisional; Region: PRK10913 1114970002872 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114970002873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002874 dimer interface [polypeptide binding]; other site 1114970002875 conserved gate region; other site 1114970002876 putative PBP binding loops; other site 1114970002877 ABC-ATPase subunit interface; other site 1114970002878 dipeptide transporter permease DppB; Provisional; Region: PRK10914 1114970002879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002880 dimer interface [polypeptide binding]; other site 1114970002881 conserved gate region; other site 1114970002882 putative PBP binding loops; other site 1114970002883 ABC-ATPase subunit interface; other site 1114970002884 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1114970002885 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1114970002886 peptide binding site [polypeptide binding]; other site 1114970002887 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970002888 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1114970002889 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1114970002890 peptide binding site [polypeptide binding]; other site 1114970002891 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1114970002892 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1114970002893 peptide binding site [polypeptide binding]; other site 1114970002894 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1114970002895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1114970002896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1114970002897 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1114970002898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970002899 active site 1114970002900 phosphorylation site [posttranslational modification] 1114970002901 intermolecular recognition site; other site 1114970002902 dimerization interface [polypeptide binding]; other site 1114970002903 Helix-turn-helix domains; Region: HTH; cl00088 1114970002904 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114970002905 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1114970002906 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 1114970002907 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970002908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970002909 DNA-binding site [nucleotide binding]; DNA binding site 1114970002910 FCD domain; Region: FCD; cl11656 1114970002911 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1114970002912 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1114970002913 putative active site [active] 1114970002914 catalytic residue [active] 1114970002915 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1114970002916 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970002917 NAD(P) binding site [chemical binding]; other site 1114970002918 catalytic residues [active] 1114970002919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970002920 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970002921 putative substrate translocation pore; other site 1114970002922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970002923 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1114970002924 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1114970002925 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1114970002926 Membrane transport protein; Region: Mem_trans; cl09117 1114970002927 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970002928 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1114970002929 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1114970002930 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1114970002931 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1114970002932 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1114970002933 GatB domain; Region: GatB_Yqey; cl11497 1114970002934 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1114970002935 Amidase; Region: Amidase; cl11426 1114970002936 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 1114970002937 rod shape-determining protein MreB; Provisional; Region: PRK13927 1114970002938 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 1114970002939 ATP binding site [chemical binding]; other site 1114970002940 profilin binding site; other site 1114970002941 rod shape-determining protein MreC; Provisional; Region: PRK13922 1114970002942 rod shape-determining protein MreC; Region: MreC; pfam04085 1114970002943 rod shape-determining protein MreD; Region: MreD; cl01087 1114970002944 Maf-like protein; Region: Maf; pfam02545 1114970002945 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1114970002946 active site 1114970002947 dimer interface [polypeptide binding]; other site 1114970002948 ribonuclease G; Provisional; Region: PRK11712 1114970002949 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1114970002950 homodimer interface [polypeptide binding]; other site 1114970002951 oligonucleotide binding site [chemical binding]; other site 1114970002952 TIGR02099 family protein; Region: TIGR02099 1114970002953 AsmA-like C-terminal region; Region: AsmA_2; cl15864 1114970002954 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114970002955 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1114970002956 putative active site [active] 1114970002957 catalytic triad [active] 1114970002958 dimer interface [polypeptide binding]; other site 1114970002959 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 1114970002960 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 1114970002961 Protein of unknown function (DUF615); Region: DUF615; cl01147 1114970002962 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 1114970002963 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 1114970002964 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1114970002965 Class II fumarases; Region: Fumarase_classII; cd01362 1114970002966 active site 1114970002967 tetramer interface [polypeptide binding]; other site 1114970002968 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1114970002969 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1114970002970 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1114970002971 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1114970002972 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114970002973 dimerization domain swap beta strand [polypeptide binding]; other site 1114970002974 regulatory protein interface [polypeptide binding]; other site 1114970002975 active site 1114970002976 regulatory phosphorylation site [posttranslational modification]; other site 1114970002977 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1114970002978 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1114970002979 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114970002980 active site 1114970002981 phosphorylation site [posttranslational modification] 1114970002982 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 1114970002983 30S subunit binding site; other site 1114970002984 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1114970002985 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1114970002986 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1114970002987 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1114970002988 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1114970002989 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 1114970002990 Walker A/P-loop; other site 1114970002991 ATP binding site [chemical binding]; other site 1114970002992 Q-loop/lid; other site 1114970002993 ABC transporter signature motif; other site 1114970002994 Walker B; other site 1114970002995 D-loop; other site 1114970002996 H-loop/switch region; other site 1114970002997 OstA-like protein; Region: OstA; cl00844 1114970002998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 1114970002999 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1114970003000 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114970003001 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 1114970003002 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1114970003003 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1114970003004 putative active site [active] 1114970003005 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1114970003006 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1114970003007 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 1114970003008 Walker A/P-loop; other site 1114970003009 ATP binding site [chemical binding]; other site 1114970003010 Q-loop/lid; other site 1114970003011 ABC transporter signature motif; other site 1114970003012 Walker B; other site 1114970003013 D-loop; other site 1114970003014 H-loop/switch region; other site 1114970003015 Permease; Region: Permease; cl00510 1114970003016 mce related protein; Region: MCE; pfam02470 1114970003017 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 1114970003018 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1114970003019 anti sigma factor interaction site; other site 1114970003020 regulatory phosphorylation site [posttranslational modification]; other site 1114970003021 BolA-like protein; Region: BolA; cl00386 1114970003022 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1114970003023 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1114970003024 hinge; other site 1114970003025 active site 1114970003026 ATP phosphoribosyltransferase; Region: HisG; cl15266 1114970003027 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1114970003028 histidinol dehydrogenase; Region: hisD; TIGR00069 1114970003029 NAD binding site [chemical binding]; other site 1114970003030 dimerization interface [polypeptide binding]; other site 1114970003031 product binding site; other site 1114970003032 substrate binding site [chemical binding]; other site 1114970003033 zinc binding site [ion binding]; other site 1114970003034 catalytic residues [active] 1114970003035 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1114970003036 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970003037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970003038 homodimer interface [polypeptide binding]; other site 1114970003039 catalytic residue [active] 1114970003040 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970003041 dimerization interface [polypeptide binding]; other site 1114970003042 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970003043 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970003044 dimer interface [polypeptide binding]; other site 1114970003045 putative CheW interface [polypeptide binding]; other site 1114970003046 Peptidase family M48; Region: Peptidase_M48; cl12018 1114970003047 Predicted membrane protein [Function unknown]; Region: COG2119 1114970003048 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1114970003049 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1114970003050 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1114970003051 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1114970003052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970003053 S-adenosylmethionine binding site [chemical binding]; other site 1114970003054 glycerate dehydrogenase; Provisional; Region: PRK06487 1114970003055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970003056 LysE type translocator; Region: LysE; cl00565 1114970003057 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1114970003058 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970003059 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1114970003060 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1114970003061 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1114970003062 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970003063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970003064 DNA binding residues [nucleotide binding] 1114970003065 dimerization interface [polypeptide binding]; other site 1114970003066 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1114970003067 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1114970003068 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114970003069 DNA binding site [nucleotide binding] 1114970003070 active site 1114970003071 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1114970003072 metal binding site [ion binding]; metal-binding site 1114970003073 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1114970003074 putative active site [active] 1114970003075 putative metal binding site [ion binding]; other site 1114970003076 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1114970003077 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1114970003078 DctM-like transporters; Region: DctM; pfam06808 1114970003079 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1114970003080 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1114970003081 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1114970003082 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1114970003083 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1114970003084 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1114970003085 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1114970003086 dimer interface [polypeptide binding]; other site 1114970003087 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970003088 metal binding site [ion binding]; metal-binding site 1114970003089 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114970003090 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1114970003091 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 1114970003092 Protein of unknown function, DUF488; Region: DUF488; cl01246 1114970003093 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970003094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003095 active site 1114970003096 phosphorylation site [posttranslational modification] 1114970003097 intermolecular recognition site; other site 1114970003098 dimerization interface [polypeptide binding]; other site 1114970003099 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970003100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970003101 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1114970003102 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1114970003103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970003104 dimer interface [polypeptide binding]; other site 1114970003105 phosphorylation site [posttranslational modification] 1114970003106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970003107 ATP binding site [chemical binding]; other site 1114970003108 Mg2+ binding site [ion binding]; other site 1114970003109 G-X-G motif; other site 1114970003110 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970003111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003112 active site 1114970003113 phosphorylation site [posttranslational modification] 1114970003114 intermolecular recognition site; other site 1114970003115 dimerization interface [polypeptide binding]; other site 1114970003116 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1114970003117 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970003118 N-terminal plug; other site 1114970003119 ligand-binding site [chemical binding]; other site 1114970003120 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970003121 PAS domain; Region: PAS_9; pfam13426 1114970003122 putative active site [active] 1114970003123 heme pocket [chemical binding]; other site 1114970003124 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970003125 metal binding site [ion binding]; metal-binding site 1114970003126 active site 1114970003127 I-site; other site 1114970003128 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 1114970003129 S-type Pyocin; Region: Pyocin_S; pfam06958 1114970003130 Cytotoxic; Region: Cytotoxic; pfam09000 1114970003131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970003132 Helix-turn-helix domains; Region: HTH; cl00088 1114970003133 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970003134 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970003135 Integrase core domain; Region: rve; cl01316 1114970003136 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970003137 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970003138 TIR domain; Region: TIR_2; cl15770 1114970003139 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 1114970003140 RES domain; Region: RES; cl02411 1114970003141 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1114970003142 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 1114970003143 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1114970003144 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1114970003145 Preprotein translocase subunit; Region: YajC; cl00806 1114970003146 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 1114970003147 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1114970003148 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1114970003149 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970003150 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1114970003151 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1114970003152 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970003153 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1114970003154 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1114970003155 active site 1114970003156 dimerization interface [polypeptide binding]; other site 1114970003157 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1114970003158 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1114970003159 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1114970003160 serine O-acetyltransferase; Region: cysE; TIGR01172 1114970003161 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1114970003162 trimer interface [polypeptide binding]; other site 1114970003163 active site 1114970003164 substrate binding site [chemical binding]; other site 1114970003165 CoA binding site [chemical binding]; other site 1114970003166 Predicted transcriptional regulator [Transcription]; Region: COG1959 1114970003167 Helix-turn-helix domains; Region: HTH; cl00088 1114970003168 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970003169 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1114970003170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970003171 catalytic residue [active] 1114970003172 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1114970003173 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1114970003174 trimerization site [polypeptide binding]; other site 1114970003175 active site 1114970003176 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1114970003177 co-chaperone HscB; Provisional; Region: hscB; PRK00294 1114970003178 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114970003179 HSP70 interaction site [polypeptide binding]; other site 1114970003180 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1114970003181 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1114970003182 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1114970003183 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970003184 catalytic loop [active] 1114970003185 iron binding site [ion binding]; other site 1114970003186 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 1114970003187 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1114970003188 active site 1114970003189 multimer interface [polypeptide binding]; other site 1114970003190 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1114970003191 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970003192 FeS/SAM binding site; other site 1114970003193 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1114970003194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970003195 binding surface 1114970003196 TPR motif; other site 1114970003197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970003198 binding surface 1114970003199 TPR motif; other site 1114970003200 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1114970003201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970003202 non-specific DNA binding site [nucleotide binding]; other site 1114970003203 salt bridge; other site 1114970003204 sequence-specific DNA binding site [nucleotide binding]; other site 1114970003205 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1114970003206 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1114970003207 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1114970003208 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1114970003209 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1114970003210 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1114970003211 dimer interface [polypeptide binding]; other site 1114970003212 motif 1; other site 1114970003213 active site 1114970003214 motif 2; other site 1114970003215 motif 3; other site 1114970003216 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1114970003217 anticodon binding site; other site 1114970003218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1114970003219 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1114970003220 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1114970003221 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1114970003222 Trp docking motif [polypeptide binding]; other site 1114970003223 GTP-binding protein Der; Reviewed; Region: PRK00093 1114970003224 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1114970003225 G1 box; other site 1114970003226 GTP/Mg2+ binding site [chemical binding]; other site 1114970003227 Switch I region; other site 1114970003228 G2 box; other site 1114970003229 Switch II region; other site 1114970003230 G3 box; other site 1114970003231 G4 box; other site 1114970003232 G5 box; other site 1114970003233 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1114970003234 G1 box; other site 1114970003235 GTP/Mg2+ binding site [chemical binding]; other site 1114970003236 Switch I region; other site 1114970003237 G2 box; other site 1114970003238 G3 box; other site 1114970003239 Switch II region; other site 1114970003240 G4 box; other site 1114970003241 G5 box; other site 1114970003242 methionine aminotransferase; Validated; Region: PRK09082 1114970003243 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970003244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970003245 homodimer interface [polypeptide binding]; other site 1114970003246 catalytic residue [active] 1114970003247 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114970003248 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1114970003249 putative active site [active] 1114970003250 catalytic triad [active] 1114970003251 dimer interface [polypeptide binding]; other site 1114970003252 multimer interface [polypeptide binding]; other site 1114970003253 2-isopropylmalate synthase; Validated; Region: PRK03739 1114970003254 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1114970003255 active site 1114970003256 catalytic residues [active] 1114970003257 metal binding site [ion binding]; metal-binding site 1114970003258 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1114970003259 Peptidase family M23; Region: Peptidase_M23; pfam01551 1114970003260 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1114970003261 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1114970003262 generic binding surface II; other site 1114970003263 generic binding surface I; other site 1114970003264 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114970003265 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1114970003266 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1114970003267 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 1114970003268 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1114970003269 active site 1114970003270 GMP synthase; Reviewed; Region: guaA; PRK00074 1114970003271 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1114970003272 AMP/PPi binding site [chemical binding]; other site 1114970003273 candidate oxyanion hole; other site 1114970003274 catalytic triad [active] 1114970003275 potential glutamine specificity residues [chemical binding]; other site 1114970003276 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1114970003277 ATP Binding subdomain [chemical binding]; other site 1114970003278 Ligand Binding sites [chemical binding]; other site 1114970003279 Dimerization subdomain; other site 1114970003280 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1114970003281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970003282 DNA-binding site [nucleotide binding]; DNA binding site 1114970003283 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1114970003284 UTRA domain; Region: UTRA; cl01230 1114970003285 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1114970003286 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114970003287 active site turn [active] 1114970003288 phosphorylation site [posttranslational modification] 1114970003289 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114970003290 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1114970003291 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1114970003292 Ca binding site [ion binding]; other site 1114970003293 active site 1114970003294 catalytic site [active] 1114970003295 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1114970003296 trimer interface; other site 1114970003297 sugar binding site [chemical binding]; other site 1114970003298 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1114970003299 HPr interaction site; other site 1114970003300 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1114970003301 active site 1114970003302 phosphorylation site [posttranslational modification] 1114970003303 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114970003304 dimerization domain swap beta strand [polypeptide binding]; other site 1114970003305 regulatory protein interface [polypeptide binding]; other site 1114970003306 active site 1114970003307 regulatory phosphorylation site [posttranslational modification]; other site 1114970003308 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1114970003309 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1114970003310 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1114970003311 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1114970003312 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1114970003313 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 1114970003314 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1114970003315 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1114970003316 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114970003317 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114970003318 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1114970003319 nucleoside/Zn binding site; other site 1114970003320 dimer interface [polypeptide binding]; other site 1114970003321 catalytic motif [active] 1114970003322 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114970003323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970003324 S-adenosylmethionine binding site [chemical binding]; other site 1114970003325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970003326 S-adenosylmethionine binding site [chemical binding]; other site 1114970003327 YhhN-like protein; Region: YhhN; cl01505 1114970003328 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 1114970003329 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1114970003330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970003331 Walker A motif; other site 1114970003332 ATP binding site [chemical binding]; other site 1114970003333 Walker B motif; other site 1114970003334 arginine finger; other site 1114970003335 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1114970003336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970003337 metabolite-proton symporter; Region: 2A0106; TIGR00883 1114970003338 putative substrate translocation pore; other site 1114970003339 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1114970003340 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114970003341 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114970003342 Transporter associated domain; Region: CorC_HlyC; cl08393 1114970003343 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1114970003344 signal recognition particle protein; Provisional; Region: PRK10867 1114970003345 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1114970003346 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1114970003347 P loop; other site 1114970003348 GTP binding site [chemical binding]; other site 1114970003349 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1114970003350 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 1114970003351 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1114970003352 RimM N-terminal domain; Region: RimM; pfam01782 1114970003353 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1114970003354 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1114970003355 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 1114970003356 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1114970003357 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1114970003358 active site 1114970003359 Int/Topo IB signature motif; other site 1114970003360 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1114970003361 dimerization domain [polypeptide binding]; other site 1114970003362 dimer interface [polypeptide binding]; other site 1114970003363 catalytic residues [active] 1114970003364 homoserine dehydrogenase; Provisional; Region: PRK06349 1114970003365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970003366 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1114970003367 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1114970003368 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1114970003369 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 1114970003370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970003371 catalytic residue [active] 1114970003372 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970003373 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970003374 substrate binding pocket [chemical binding]; other site 1114970003375 membrane-bound complex binding site; other site 1114970003376 hinge residues; other site 1114970003377 PAS fold; Region: PAS; pfam00989 1114970003378 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970003379 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1114970003380 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1114970003381 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1114970003382 YaeQ protein; Region: YaeQ; cl01913 1114970003383 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1114970003384 DHH family; Region: DHH; pfam01368 1114970003385 DHHA1 domain; Region: DHHA1; pfam02272 1114970003386 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1114970003387 active site 1114970003388 FMN binding site [chemical binding]; other site 1114970003389 substrate binding site [chemical binding]; other site 1114970003390 homotetramer interface [polypeptide binding]; other site 1114970003391 catalytic residue [active] 1114970003392 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1114970003393 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1114970003394 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 1114970003395 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970003396 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1114970003397 tetrameric interface [polypeptide binding]; other site 1114970003398 NAD binding site [chemical binding]; other site 1114970003399 catalytic residues [active] 1114970003400 substrate binding site [chemical binding]; other site 1114970003401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970003402 dimer interface [polypeptide binding]; other site 1114970003403 conserved gate region; other site 1114970003404 ABC-ATPase subunit interface; other site 1114970003405 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 1114970003406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970003407 conserved gate region; other site 1114970003408 dimer interface [polypeptide binding]; other site 1114970003409 putative PBP binding loops; other site 1114970003410 ABC-ATPase subunit interface; other site 1114970003411 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970003412 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970003413 Walker A/P-loop; other site 1114970003414 ATP binding site [chemical binding]; other site 1114970003415 Q-loop/lid; other site 1114970003416 ABC transporter signature motif; other site 1114970003417 Walker B; other site 1114970003418 D-loop; other site 1114970003419 H-loop/switch region; other site 1114970003420 TOBE domain; Region: TOBE_2; cl01440 1114970003421 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114970003422 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970003423 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970003424 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1114970003425 tetrameric interface [polypeptide binding]; other site 1114970003426 NAD binding site [chemical binding]; other site 1114970003427 catalytic residues [active] 1114970003428 substrate binding site [chemical binding]; other site 1114970003429 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970003430 Helix-turn-helix domains; Region: HTH; cl00088 1114970003431 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1114970003432 putative substrate binding pocket [chemical binding]; other site 1114970003433 dimerization interface [polypeptide binding]; other site 1114970003434 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1114970003435 putative metal binding site [ion binding]; other site 1114970003436 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970003437 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970003438 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970003439 dimer interface [polypeptide binding]; other site 1114970003440 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1114970003441 putative CheW interface [polypeptide binding]; other site 1114970003442 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1114970003443 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1114970003444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970003445 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1114970003446 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970003447 putative binding surface; other site 1114970003448 active site 1114970003449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970003450 ATP binding site [chemical binding]; other site 1114970003451 Mg2+ binding site [ion binding]; other site 1114970003452 G-X-G motif; other site 1114970003453 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1114970003454 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970003455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003456 active site 1114970003457 phosphorylation site [posttranslational modification] 1114970003458 intermolecular recognition site; other site 1114970003459 dimerization interface [polypeptide binding]; other site 1114970003460 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 1114970003461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003462 active site 1114970003463 phosphorylation site [posttranslational modification] 1114970003464 intermolecular recognition site; other site 1114970003465 dimerization interface [polypeptide binding]; other site 1114970003466 CheB methylesterase; Region: CheB_methylest; pfam01339 1114970003467 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970003468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003469 active site 1114970003470 phosphorylation site [posttranslational modification] 1114970003471 intermolecular recognition site; other site 1114970003472 dimerization interface [polypeptide binding]; other site 1114970003473 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970003474 metal binding site [ion binding]; metal-binding site 1114970003475 active site 1114970003476 I-site; other site 1114970003477 peptide chain release factor 2; Provisional; Region: PRK08787 1114970003478 RF-1 domain; Region: RF-1; cl02875 1114970003479 RF-1 domain; Region: RF-1; cl02875 1114970003480 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1114970003481 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1114970003482 dimer interface [polypeptide binding]; other site 1114970003483 putative anticodon binding site; other site 1114970003484 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1114970003485 motif 1; other site 1114970003486 active site 1114970003487 motif 2; other site 1114970003488 motif 3; other site 1114970003489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1114970003490 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 1114970003491 conserved hypothetical protein; Region: QEGLA; TIGR02421 1114970003492 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970003493 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1114970003494 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970003495 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970003496 ligand binding site [chemical binding]; other site 1114970003497 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1114970003498 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 1114970003499 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1114970003500 adenylate kinase; Reviewed; Region: adk; PRK00279 1114970003501 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1114970003502 AMP-binding site [chemical binding]; other site 1114970003503 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1114970003504 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1114970003505 Protein of unknown function DUF72; Region: DUF72; cl00777 1114970003506 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1114970003507 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1114970003508 tetramer interface [polypeptide binding]; other site 1114970003509 active site 1114970003510 Mg2+/Mn2+ binding site [ion binding]; other site 1114970003511 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1114970003512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970003513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970003514 Helix-turn-helix domains; Region: HTH; cl00088 1114970003515 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1114970003516 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970003517 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970003518 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970003519 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970003520 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1114970003521 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 1114970003522 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 1114970003523 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1114970003524 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1114970003525 putative acyl-acceptor binding pocket; other site 1114970003526 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1114970003527 DNA-binding site [nucleotide binding]; DNA binding site 1114970003528 RNA-binding motif; other site 1114970003529 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1114970003530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970003531 S-adenosylmethionine binding site [chemical binding]; other site 1114970003532 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1114970003533 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1114970003534 metal binding site [ion binding]; metal-binding site 1114970003535 dimer interface [polypeptide binding]; other site 1114970003536 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1114970003537 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1114970003538 putative ATP binding site [chemical binding]; other site 1114970003539 putative substrate interface [chemical binding]; other site 1114970003540 Fe-S metabolism associated domain; Region: SufE; cl00951 1114970003541 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1114970003542 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1114970003543 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970003544 catalytic residue [active] 1114970003545 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 1114970003546 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1114970003547 putative trimer interface [polypeptide binding]; other site 1114970003548 putative CoA binding site [chemical binding]; other site 1114970003549 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1114970003550 ArsC family; Region: ArsC; pfam03960 1114970003551 putative catalytic residues [active] 1114970003552 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1114970003553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970003554 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 1114970003555 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970003556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970003557 homodimer interface [polypeptide binding]; other site 1114970003558 catalytic residue [active] 1114970003559 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 1114970003560 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1114970003561 metal binding triad; other site 1114970003562 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1114970003563 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114970003564 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1114970003565 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1114970003566 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1114970003567 active site 1114970003568 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1114970003569 rRNA interaction site [nucleotide binding]; other site 1114970003570 S8 interaction site; other site 1114970003571 putative laminin-1 binding site; other site 1114970003572 elongation factor Ts; Provisional; Region: tsf; PRK09377 1114970003573 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 1114970003574 Elongation factor TS; Region: EF_TS; pfam00889 1114970003575 Elongation factor TS; Region: EF_TS; pfam00889 1114970003576 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1114970003577 putative nucleotide binding site [chemical binding]; other site 1114970003578 uridine monophosphate binding site [chemical binding]; other site 1114970003579 homohexameric interface [polypeptide binding]; other site 1114970003580 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1114970003581 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 1114970003582 hinge region; other site 1114970003583 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1114970003584 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1114970003585 catalytic residue [active] 1114970003586 putative FPP diphosphate binding site; other site 1114970003587 putative FPP binding hydrophobic cleft; other site 1114970003588 dimer interface [polypeptide binding]; other site 1114970003589 putative IPP diphosphate binding site; other site 1114970003590 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 1114970003591 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1114970003592 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1114970003593 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1114970003594 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1114970003595 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1114970003596 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1114970003597 active site 1114970003598 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1114970003599 protein binding site [polypeptide binding]; other site 1114970003600 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1114970003601 protein binding site [polypeptide binding]; other site 1114970003602 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1114970003603 putative substrate binding region [chemical binding]; other site 1114970003604 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1114970003605 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970003606 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970003607 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970003608 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970003609 Surface antigen; Region: Bac_surface_Ag; cl03097 1114970003610 periplasmic chaperone; Provisional; Region: PRK10780 1114970003611 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1114970003612 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1114970003613 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1114970003614 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1114970003615 trimer interface [polypeptide binding]; other site 1114970003616 active site 1114970003617 UDP-GlcNAc binding site [chemical binding]; other site 1114970003618 lipid binding site [chemical binding]; lipid-binding site 1114970003619 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1114970003620 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1114970003621 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1114970003622 active site 1114970003623 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1114970003624 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970003625 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1114970003626 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114970003627 active site 1114970003628 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1114970003629 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1114970003630 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1114970003631 generic binding surface II; other site 1114970003632 generic binding surface I; other site 1114970003633 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1114970003634 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114970003635 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1114970003636 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1114970003637 Ligand Binding Site [chemical binding]; other site 1114970003638 TilS substrate binding domain; Region: TilS; pfam09179 1114970003639 B3/4 domain; Region: B3_4; cl11458 1114970003640 CTP synthetase; Validated; Region: pyrG; PRK05380 1114970003641 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1114970003642 Catalytic site [active] 1114970003643 active site 1114970003644 UTP binding site [chemical binding]; other site 1114970003645 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1114970003646 active site 1114970003647 putative oxyanion hole; other site 1114970003648 catalytic triad [active] 1114970003649 NeuB family; Region: NeuB; cl00496 1114970003650 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1114970003651 enolase; Provisional; Region: eno; PRK00077 1114970003652 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1114970003653 dimer interface [polypeptide binding]; other site 1114970003654 metal binding site [ion binding]; metal-binding site 1114970003655 substrate binding pocket [chemical binding]; other site 1114970003656 Septum formation initiator; Region: DivIC; cl11433 1114970003657 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1114970003658 substrate binding site; other site 1114970003659 dimer interface; other site 1114970003660 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970003661 Helix-turn-helix domains; Region: HTH; cl00088 1114970003662 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 1114970003663 putative effector binding pocket; other site 1114970003664 putative dimerization interface [polypeptide binding]; other site 1114970003665 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1114970003666 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1114970003667 substrate binding site [chemical binding]; other site 1114970003668 catalytic Zn binding site [ion binding]; other site 1114970003669 NAD binding site [chemical binding]; other site 1114970003670 structural Zn binding site [ion binding]; other site 1114970003671 dimer interface [polypeptide binding]; other site 1114970003672 Predicted esterase [General function prediction only]; Region: COG0627 1114970003673 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970003674 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1114970003675 homotrimer interaction site [polypeptide binding]; other site 1114970003676 zinc binding site [ion binding]; other site 1114970003677 CDP-binding sites; other site 1114970003678 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1114970003679 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1114970003680 Permutation of conserved domain; other site 1114970003681 active site 1114970003682 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1114970003683 Survival protein SurE; Region: SurE; cl00448 1114970003684 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1114970003685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970003686 S-adenosylmethionine binding site [chemical binding]; other site 1114970003687 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 1114970003688 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1114970003689 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1114970003690 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970003691 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114970003692 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970003693 DNA binding residues [nucleotide binding] 1114970003694 Helix-turn-helix domains; Region: HTH; cl00088 1114970003695 putative transposase OrfB; Reviewed; Region: PHA02517 1114970003696 Helix-turn-helix domains; Region: HTH; cl00088 1114970003697 Integrase core domain; Region: rve; cl01316 1114970003698 Integrase core domain; Region: rve_3; cl15866 1114970003699 Ferredoxin [Energy production and conversion]; Region: COG1146 1114970003700 4Fe-4S binding domain; Region: Fer4; cl02805 1114970003701 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1114970003702 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1114970003703 MutS domain I; Region: MutS_I; pfam01624 1114970003704 MutS domain II; Region: MutS_II; pfam05188 1114970003705 MutS family domain IV; Region: MutS_IV; pfam05190 1114970003706 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 1114970003707 Walker A/P-loop; other site 1114970003708 ATP binding site [chemical binding]; other site 1114970003709 Q-loop/lid; other site 1114970003710 ABC transporter signature motif; other site 1114970003711 Walker B; other site 1114970003712 D-loop; other site 1114970003713 H-loop/switch region; other site 1114970003714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970003715 non-specific DNA binding site [nucleotide binding]; other site 1114970003716 salt bridge; other site 1114970003717 sequence-specific DNA binding site [nucleotide binding]; other site 1114970003718 Predicted transcriptional regulator [Transcription]; Region: COG2932 1114970003719 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970003720 Catalytic site [active] 1114970003721 hypothetical protein; Provisional; Region: PLN03089 1114970003722 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1114970003723 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970003724 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1114970003725 Baseplate J-like protein; Region: Baseplate_J; cl01294 1114970003726 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 1114970003727 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1114970003728 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1114970003729 Phage tail tube protein FII; Region: Phage_tube; cl01390 1114970003730 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1114970003731 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1114970003732 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1114970003733 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 1114970003734 Phage Tail Protein X; Region: Phage_tail_X; cl02088 1114970003735 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1114970003736 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1114970003737 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1114970003738 catalytic residue [active] 1114970003739 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1114970003740 Competence-damaged protein; Region: CinA; cl00666 1114970003741 recombinase A; Provisional; Region: recA; PRK09354 1114970003742 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1114970003743 hexamer interface [polypeptide binding]; other site 1114970003744 Walker A motif; other site 1114970003745 ATP binding site [chemical binding]; other site 1114970003746 Walker B motif; other site 1114970003747 RecX family; Region: RecX; cl00936 1114970003748 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1114970003749 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 1114970003750 DTW domain; Region: DTW; cl01221 1114970003751 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970003752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003753 active site 1114970003754 phosphorylation site [posttranslational modification] 1114970003755 intermolecular recognition site; other site 1114970003756 dimerization interface [polypeptide binding]; other site 1114970003757 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970003758 DNA binding residues [nucleotide binding] 1114970003759 dimerization interface [polypeptide binding]; other site 1114970003760 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 1114970003761 Helix-turn-helix domains; Region: HTH; cl00088 1114970003762 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1114970003763 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1114970003764 putative dimerization interface [polypeptide binding]; other site 1114970003765 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1114970003766 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1114970003767 FAD binding pocket [chemical binding]; other site 1114970003768 FAD binding motif [chemical binding]; other site 1114970003769 phosphate binding motif [ion binding]; other site 1114970003770 beta-alpha-beta structure motif; other site 1114970003771 NAD binding pocket [chemical binding]; other site 1114970003772 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1114970003773 homodimer interaction site [polypeptide binding]; other site 1114970003774 cofactor binding site; other site 1114970003775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1114970003776 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1114970003777 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1114970003778 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1114970003779 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114970003780 RNA binding surface [nucleotide binding]; other site 1114970003781 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 1114970003782 active site 1114970003783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114970003784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970003785 Coenzyme A binding pocket [chemical binding]; other site 1114970003786 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1114970003787 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1114970003788 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970003789 FeS/SAM binding site; other site 1114970003790 TRAM domain; Region: TRAM; cl01282 1114970003791 K+ potassium transporter; Region: K_trans; cl15781 1114970003792 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1114970003793 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1114970003794 Predicted integral membrane protein [Function unknown]; Region: COG0392 1114970003795 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1114970003796 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1114970003797 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1114970003798 active site 1114970003799 DNA polymerase IV; Validated; Region: PRK02406 1114970003800 DNA binding site [nucleotide binding] 1114970003801 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1114970003802 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 1114970003803 dimer interface [polypeptide binding]; other site 1114970003804 motif 1; other site 1114970003805 active site 1114970003806 motif 2; other site 1114970003807 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1114970003808 putative deacylase active site [active] 1114970003809 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1114970003810 active site 1114970003811 motif 3; other site 1114970003812 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1114970003813 anticodon binding site; other site 1114970003814 muropeptide transporter; Validated; Region: ampG; PRK11010 1114970003815 muropeptide transporter; Validated; Region: ampG; PRK11010 1114970003816 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114970003817 active site 1114970003818 DNA binding site [nucleotide binding] 1114970003819 Protein of unknown function, DUF481; Region: DUF481; cl01213 1114970003820 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1114970003821 DNA-binding site [nucleotide binding]; DNA binding site 1114970003822 RNA-binding motif; other site 1114970003823 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1114970003824 trimer interface [polypeptide binding]; other site 1114970003825 active site 1114970003826 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1114970003827 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970003828 Walker A/P-loop; other site 1114970003829 ATP binding site [chemical binding]; other site 1114970003830 Q-loop/lid; other site 1114970003831 ABC transporter signature motif; other site 1114970003832 Walker B; other site 1114970003833 D-loop; other site 1114970003834 H-loop/switch region; other site 1114970003835 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1114970003836 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1114970003837 active site 1114970003838 Zn binding site [ion binding]; other site 1114970003839 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970003840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970003841 dimer interface [polypeptide binding]; other site 1114970003842 conserved gate region; other site 1114970003843 putative PBP binding loops; other site 1114970003844 ABC-ATPase subunit interface; other site 1114970003845 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970003846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970003847 dimer interface [polypeptide binding]; other site 1114970003848 conserved gate region; other site 1114970003849 putative PBP binding loops; other site 1114970003850 ABC-ATPase subunit interface; other site 1114970003851 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1114970003852 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970003853 substrate binding pocket [chemical binding]; other site 1114970003854 membrane-bound complex binding site; other site 1114970003855 hinge residues; other site 1114970003856 ATP-dependent DNA ligase; Validated; Region: PRK09247 1114970003857 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 1114970003858 active site 1114970003859 DNA binding site [nucleotide binding] 1114970003860 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1114970003861 DNA binding site [nucleotide binding] 1114970003862 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 1114970003863 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970003864 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1114970003865 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1114970003866 active site 1114970003867 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970003868 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1114970003869 catalytic triad [active] 1114970003870 conserved cis-peptide bond; other site 1114970003871 Late embryogenesis abundant protein; Region: LEA_2; cl12118 1114970003872 hypothetical protein; Provisional; Region: PRK00183 1114970003873 SEC-C motif; Region: SEC-C; pfam02810 1114970003874 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970003875 ligand binding site [chemical binding]; other site 1114970003876 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970003877 ligand binding site [chemical binding]; other site 1114970003878 Copper resistance protein D; Region: CopD; cl00563 1114970003879 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1114970003880 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970003881 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970003882 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970003883 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114970003884 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970003885 ligand binding site [chemical binding]; other site 1114970003886 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1114970003887 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1114970003888 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1114970003889 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1114970003890 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1114970003891 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1114970003892 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1114970003893 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970003894 catalytic residue [active] 1114970003895 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1114970003896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970003897 Predicted membrane protein [Function unknown]; Region: COG3650 1114970003898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970003899 NAD(P) binding site [chemical binding]; other site 1114970003900 active site 1114970003901 transcriptional regulator; Provisional; Region: PRK10632 1114970003902 Helix-turn-helix domains; Region: HTH; cl00088 1114970003903 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970003904 putative effector binding pocket; other site 1114970003905 dimerization interface [polypeptide binding]; other site 1114970003906 DoxX; Region: DoxX; cl00976 1114970003907 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 1114970003908 Protein of unknown function (DUF692); Region: DUF692; cl01263 1114970003909 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 1114970003910 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1114970003911 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 1114970003912 Walker A/P-loop; other site 1114970003913 ATP binding site [chemical binding]; other site 1114970003914 Q-loop/lid; other site 1114970003915 ABC transporter signature motif; other site 1114970003916 Walker B; other site 1114970003917 D-loop; other site 1114970003918 H-loop/switch region; other site 1114970003919 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1114970003920 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 1114970003921 Walker A/P-loop; other site 1114970003922 ATP binding site [chemical binding]; other site 1114970003923 Q-loop/lid; other site 1114970003924 ABC transporter signature motif; other site 1114970003925 Walker B; other site 1114970003926 D-loop; other site 1114970003927 H-loop/switch region; other site 1114970003928 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1114970003929 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1114970003930 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1114970003931 TM-ABC transporter signature motif; other site 1114970003932 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1114970003933 TM-ABC transporter signature motif; other site 1114970003934 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 1114970003935 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1114970003936 dimerization interface [polypeptide binding]; other site 1114970003937 ligand binding site [chemical binding]; other site 1114970003938 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 1114970003939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970003940 putative substrate translocation pore; other site 1114970003941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970003942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970003943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970003944 putative substrate translocation pore; other site 1114970003945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970003946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970003947 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1114970003948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970003949 Cupin domain; Region: Cupin_2; cl09118 1114970003950 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970003951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970003952 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1114970003953 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1114970003954 putative substrate binding site [chemical binding]; other site 1114970003955 nucleotide binding site [chemical binding]; other site 1114970003956 nucleotide binding site [chemical binding]; other site 1114970003957 homodimer interface [polypeptide binding]; other site 1114970003958 ornithine carbamoyltransferase; Validated; Region: PRK02102 1114970003959 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114970003960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970003961 Amidinotransferase; Region: Amidinotransf; cl12043 1114970003962 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1114970003963 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1114970003964 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1114970003965 Protein of unknown function (DUF454); Region: DUF454; cl01063 1114970003966 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1114970003967 heme binding pocket [chemical binding]; other site 1114970003968 heme ligand [chemical binding]; other site 1114970003969 Secretin and TonB N terminus short domain; Region: STN; cl06624 1114970003970 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1114970003971 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970003972 N-terminal plug; other site 1114970003973 ligand-binding site [chemical binding]; other site 1114970003974 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970003975 FecR protein; Region: FecR; pfam04773 1114970003976 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1114970003977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970003978 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970003979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970003980 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1114970003981 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1114970003982 Dehydratase family; Region: ILVD_EDD; cl00340 1114970003983 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1114970003984 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1114970003985 glucokinase, proteobacterial type; Region: glk; TIGR00749 1114970003986 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1114970003987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003988 active site 1114970003989 phosphorylation site [posttranslational modification] 1114970003990 intermolecular recognition site; other site 1114970003991 dimerization interface [polypeptide binding]; other site 1114970003992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970003993 DNA binding site [nucleotide binding] 1114970003994 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1114970003995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970003996 ATP binding site [chemical binding]; other site 1114970003997 Mg2+ binding site [ion binding]; other site 1114970003998 G-X-G motif; other site 1114970003999 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 1114970004000 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1114970004001 dimerization interface [polypeptide binding]; other site 1114970004002 putative active cleft [active] 1114970004003 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114970004004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970004005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970004006 dimer interface [polypeptide binding]; other site 1114970004007 conserved gate region; other site 1114970004008 putative PBP binding loops; other site 1114970004009 ABC-ATPase subunit interface; other site 1114970004010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970004011 dimer interface [polypeptide binding]; other site 1114970004012 conserved gate region; other site 1114970004013 putative PBP binding loops; other site 1114970004014 ABC-ATPase subunit interface; other site 1114970004015 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1114970004016 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1114970004017 Walker A/P-loop; other site 1114970004018 ATP binding site [chemical binding]; other site 1114970004019 Q-loop/lid; other site 1114970004020 ABC transporter signature motif; other site 1114970004021 Walker B; other site 1114970004022 D-loop; other site 1114970004023 H-loop/switch region; other site 1114970004024 TOBE domain; Region: TOBE_2; cl01440 1114970004025 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1114970004026 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1114970004027 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1114970004028 active site 1114970004029 phosphate binding residues; other site 1114970004030 catalytic residues [active] 1114970004031 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1114970004032 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114970004033 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114970004034 putative active site [active] 1114970004035 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1114970004036 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1114970004037 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1114970004038 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1114970004039 putative active site [active] 1114970004040 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1114970004041 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1114970004042 active site 1114970004043 intersubunit interface [polypeptide binding]; other site 1114970004044 catalytic residue [active] 1114970004045 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1114970004046 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970004047 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970004048 catalytic residue [active] 1114970004049 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 1114970004050 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1114970004051 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1114970004052 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1114970004053 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 1114970004054 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1114970004055 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970004056 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970004057 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1114970004058 dimer interaction site [polypeptide binding]; other site 1114970004059 substrate-binding tunnel; other site 1114970004060 active site 1114970004061 catalytic site [active] 1114970004062 substrate binding site [chemical binding]; other site 1114970004063 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114970004064 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970004065 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970004066 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970004067 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 1114970004068 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970004069 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970004070 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 1114970004071 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970004072 MAC/Perforin domain; Region: MACPF; cl02616 1114970004073 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1114970004074 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1114970004075 active site 1114970004076 catalytic residues [active] 1114970004077 metal binding site [ion binding]; metal-binding site 1114970004078 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970004079 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970004080 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970004081 DNA binding site [nucleotide binding] 1114970004082 domain linker motif; other site 1114970004083 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1114970004084 putative ligand binding site [chemical binding]; other site 1114970004085 putative dimerization interface [polypeptide binding]; other site 1114970004086 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1114970004087 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 1114970004088 ATP-binding site [chemical binding]; other site 1114970004089 Gluconate-6-phosphate binding site [chemical binding]; other site 1114970004090 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1114970004091 GntP family permease; Region: GntP_permease; pfam02447 1114970004092 aminotransferase; Validated; Region: PRK08175 1114970004093 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970004094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970004095 homodimer interface [polypeptide binding]; other site 1114970004096 catalytic residue [active] 1114970004097 LysE type translocator; Region: LysE; cl00565 1114970004098 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1114970004099 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1114970004100 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970004101 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970004102 YCII-related domain; Region: YCII; cl00999 1114970004103 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1114970004104 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1114970004105 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970004106 Imelysin; Region: Peptidase_M75; cl09159 1114970004107 biofilm formation regulator HmsP; Provisional; Region: PRK11829 1114970004108 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970004109 metal binding site [ion binding]; metal-binding site 1114970004110 active site 1114970004111 I-site; other site 1114970004112 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970004113 superoxide dismutase; Provisional; Region: PRK10543 1114970004114 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1114970004115 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1114970004116 LysE type translocator; Region: LysE; cl00565 1114970004117 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1114970004118 Helix-turn-helix domains; Region: HTH; cl00088 1114970004119 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970004120 dimerization interface [polypeptide binding]; other site 1114970004121 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970004122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970004123 NAD(P) binding site [chemical binding]; other site 1114970004124 active site 1114970004125 Cache domain; Region: Cache_2; cl07034 1114970004126 Cache domain; Region: Cache_2; cl07034 1114970004127 ATP-dependent helicase HepA; Validated; Region: PRK04914 1114970004128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970004129 ATP binding site [chemical binding]; other site 1114970004130 putative Mg++ binding site [ion binding]; other site 1114970004131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970004132 nucleotide binding region [chemical binding]; other site 1114970004133 ATP-binding site [chemical binding]; other site 1114970004134 Phosphate transporter family; Region: PHO4; cl00396 1114970004135 Phosphate transporter family; Region: PHO4; cl00396 1114970004136 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1114970004137 Helix-turn-helix domains; Region: HTH; cl00088 1114970004138 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970004139 benzoate transport; Region: 2A0115; TIGR00895 1114970004140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970004141 putative substrate translocation pore; other site 1114970004142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970004143 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114970004144 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114970004145 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1114970004146 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970004147 dimer interface [polypeptide binding]; other site 1114970004148 active site 1114970004149 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1114970004150 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1114970004151 heterodimer interface [polypeptide binding]; other site 1114970004152 multimer interface [polypeptide binding]; other site 1114970004153 active site 1114970004154 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1114970004155 heterodimer interface [polypeptide binding]; other site 1114970004156 active site 1114970004157 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1114970004158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970004159 putative substrate translocation pore; other site 1114970004160 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1114970004161 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1114970004162 tetramer interface [polypeptide binding]; other site 1114970004163 active site 1114970004164 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1114970004165 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970004166 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970004167 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970004168 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1114970004169 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970004170 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970004171 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1114970004172 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970004173 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970004174 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1114970004175 Helix-turn-helix domains; Region: HTH; cl00088 1114970004176 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1114970004177 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1114970004178 FMN binding site [chemical binding]; other site 1114970004179 active site 1114970004180 substrate binding site [chemical binding]; other site 1114970004181 catalytic residue [active] 1114970004182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970004183 putative substrate translocation pore; other site 1114970004184 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970004185 dimerization interface [polypeptide binding]; other site 1114970004186 putative DNA binding site [nucleotide binding]; other site 1114970004187 putative Zn2+ binding site [ion binding]; other site 1114970004188 Protein of unknown function, DUF479; Region: DUF479; cl01203 1114970004189 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114970004190 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114970004191 putative acyl-acceptor binding pocket; other site 1114970004192 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970004193 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970004194 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114970004195 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970004196 YceI-like domain; Region: YceI; cl01001 1114970004197 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1114970004198 putative active site [active] 1114970004199 catalytic site [active] 1114970004200 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1114970004201 PLD-like domain; Region: PLDc_2; pfam13091 1114970004202 putative active site [active] 1114970004203 catalytic site [active] 1114970004204 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1114970004205 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1114970004206 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1114970004207 LemA family; Region: LemA; cl00742 1114970004208 Repair protein; Region: Repair_PSII; cl01535 1114970004209 Repair protein; Region: Repair_PSII; cl01535 1114970004210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970004211 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114970004212 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1114970004213 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1114970004214 conserved cys residue [active] 1114970004215 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1114970004216 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1114970004217 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1114970004218 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1114970004219 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1114970004220 dimer interface [polypeptide binding]; other site 1114970004221 active site 1114970004222 metal binding site [ion binding]; metal-binding site 1114970004223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970004224 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1114970004225 putative substrate translocation pore; other site 1114970004226 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1114970004227 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970004228 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970004229 catalytic residue [active] 1114970004230 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1114970004231 dimer interface [polypeptide binding]; other site 1114970004232 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970004233 Mn binding site [ion binding]; other site 1114970004234 K binding site [ion binding]; other site 1114970004235 PAS fold; Region: PAS; pfam00989 1114970004236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970004237 putative active site [active] 1114970004238 heme pocket [chemical binding]; other site 1114970004239 GAF domain; Region: GAF; cl15785 1114970004240 GAF domain; Region: GAF_2; pfam13185 1114970004241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970004242 metal binding site [ion binding]; metal-binding site 1114970004243 active site 1114970004244 I-site; other site 1114970004245 Domain of unknown function (DUF305); Region: DUF305; cl15795 1114970004246 Low affinity iron permease; Region: Iron_permease; cl12096 1114970004247 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1114970004248 YcfA-like protein; Region: YcfA; cl00752 1114970004249 LysE type translocator; Region: LysE; cl00565 1114970004250 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970004251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970004252 putative DNA binding site [nucleotide binding]; other site 1114970004253 putative Zn2+ binding site [ion binding]; other site 1114970004254 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970004255 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1114970004256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970004257 Zeta toxin; Region: Zeta_toxin; pfam06414 1114970004258 Walker A motif; other site 1114970004259 ATP binding site [chemical binding]; other site 1114970004260 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970004261 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1114970004262 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1114970004263 active site 1114970004264 uracil binding [chemical binding]; other site 1114970004265 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 1114970004266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970004267 metal binding site [ion binding]; metal-binding site 1114970004268 active site 1114970004269 I-site; other site 1114970004270 allophanate hydrolase; Provisional; Region: PRK08186 1114970004271 Amidase; Region: Amidase; cl11426 1114970004272 urea carboxylase; Region: urea_carbox; TIGR02712 1114970004273 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970004274 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970004275 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1114970004276 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1114970004277 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1114970004278 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970004279 carboxyltransferase (CT) interaction site; other site 1114970004280 biotinylation site [posttranslational modification]; other site 1114970004281 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1114970004282 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1114970004283 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1114970004284 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1114970004285 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1114970004286 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1114970004287 Walker A/P-loop; other site 1114970004288 ATP binding site [chemical binding]; other site 1114970004289 Q-loop/lid; other site 1114970004290 ABC transporter signature motif; other site 1114970004291 Walker B; other site 1114970004292 D-loop; other site 1114970004293 H-loop/switch region; other site 1114970004294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1114970004295 NMT1-like family; Region: NMT1_2; cl15260 1114970004296 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1114970004297 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1114970004298 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970004299 substrate binding site [chemical binding]; other site 1114970004300 oxyanion hole (OAH) forming residues; other site 1114970004301 trimer interface [polypeptide binding]; other site 1114970004302 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1114970004303 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1114970004304 ligand binding site [chemical binding]; other site 1114970004305 active site 1114970004306 UGI interface [polypeptide binding]; other site 1114970004307 catalytic site [active] 1114970004308 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1114970004309 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1114970004310 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1114970004311 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1114970004312 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1114970004313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1114970004314 NMT1-like family; Region: NMT1_2; cl15260 1114970004315 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970004316 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1114970004317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970004318 active site 1114970004319 phosphorylation site [posttranslational modification] 1114970004320 intermolecular recognition site; other site 1114970004321 dimerization interface [polypeptide binding]; other site 1114970004322 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970004323 DNA binding site [nucleotide binding] 1114970004324 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1114970004325 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970004326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970004327 dimer interface [polypeptide binding]; other site 1114970004328 phosphorylation site [posttranslational modification] 1114970004329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970004330 ATP binding site [chemical binding]; other site 1114970004331 Mg2+ binding site [ion binding]; other site 1114970004332 G-X-G motif; other site 1114970004333 HDOD domain; Region: HDOD; pfam08668 1114970004334 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1114970004335 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1114970004336 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 1114970004337 L-aspartate oxidase; Provisional; Region: PRK09077 1114970004338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970004339 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1114970004340 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 1114970004341 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970004342 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970004343 DNA binding residues [nucleotide binding] 1114970004344 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 1114970004345 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1114970004346 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1114970004347 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 1114970004348 MucB/RseB family; Region: MucB_RseB; pfam03888 1114970004349 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1114970004350 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1114970004351 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114970004352 protein binding site [polypeptide binding]; other site 1114970004353 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114970004354 protein binding site [polypeptide binding]; other site 1114970004355 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1114970004356 Peptidase family M48; Region: Peptidase_M48; cl12018 1114970004357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114970004358 binding surface 1114970004359 TPR motif; other site 1114970004360 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1114970004361 CPxP motif; other site 1114970004362 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114970004363 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1114970004364 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1114970004365 catalytic triad [active] 1114970004366 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1114970004367 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1114970004368 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1114970004369 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1114970004370 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1114970004371 dimer interface [polypeptide binding]; other site 1114970004372 active site 1114970004373 catalytic residue [active] 1114970004374 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1114970004375 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1114970004376 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970004377 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1114970004378 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1114970004379 ATP binding site [chemical binding]; other site 1114970004380 active site 1114970004381 substrate binding site [chemical binding]; other site 1114970004382 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 1114970004383 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1114970004384 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114970004385 MULE transposase domain; Region: MULE; pfam10551 1114970004386 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970004387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970004388 dimerization interface [polypeptide binding]; other site 1114970004389 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970004390 dimer interface [polypeptide binding]; other site 1114970004391 putative CheW interface [polypeptide binding]; other site 1114970004392 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1114970004393 Cupin domain; Region: Cupin_2; cl09118 1114970004394 Cupin domain; Region: Cupin_2; cl09118 1114970004395 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970004396 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970004397 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1114970004398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970004399 Helix-turn-helix domains; Region: HTH; cl00088 1114970004400 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1114970004401 putative substrate binding pocket [chemical binding]; other site 1114970004402 putative dimerization interface [polypeptide binding]; other site 1114970004403 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1114970004404 putative substrate binding pocket [chemical binding]; other site 1114970004405 trimer interface [polypeptide binding]; other site 1114970004406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970004407 Helix-turn-helix domains; Region: HTH; cl00088 1114970004408 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1114970004409 substrate binding pocket [chemical binding]; other site 1114970004410 dimerization interface [polypeptide binding]; other site 1114970004411 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1114970004412 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970004413 putative metal dependent hydrolase; Provisional; Region: PRK11598 1114970004414 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1114970004415 Sulfatase; Region: Sulfatase; cl10460 1114970004416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970004417 S-adenosylmethionine binding site [chemical binding]; other site 1114970004418 ribonuclease D; Region: rnd; TIGR01388 1114970004419 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1114970004420 catalytic site [active] 1114970004421 putative active site [active] 1114970004422 putative substrate binding site [chemical binding]; other site 1114970004423 HRDC domain; Region: HRDC; cl02578 1114970004424 YcgL domain; Region: YcgL; cl01189 1114970004425 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1114970004426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970004427 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1114970004428 putative FMN binding site [chemical binding]; other site 1114970004429 Flagellin N-methylase; Region: FliB; cl00497 1114970004430 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1114970004431 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1114970004432 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1114970004433 hypothetical protein; Provisional; Region: PRK11295 1114970004434 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1114970004435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970004436 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970004437 ligand binding site [chemical binding]; other site 1114970004438 flexible hinge region; other site 1114970004439 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1114970004440 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970004441 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1114970004442 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1114970004443 putative active site [active] 1114970004444 putative dimer interface [polypeptide binding]; other site 1114970004445 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 1114970004446 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114970004447 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114970004448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970004449 Walker A motif; other site 1114970004450 ATP binding site [chemical binding]; other site 1114970004451 Walker B motif; other site 1114970004452 arginine finger; other site 1114970004453 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1114970004454 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1114970004455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970004456 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1114970004457 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1114970004458 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1114970004459 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114970004460 dimer interface [polypeptide binding]; other site 1114970004461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970004462 catalytic residue [active] 1114970004463 Cupin domain; Region: Cupin_2; cl09118 1114970004464 EamA-like transporter family; Region: EamA; cl01037 1114970004465 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114970004466 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891 1114970004467 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1114970004468 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1114970004469 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970004470 ATP binding site [chemical binding]; other site 1114970004471 putative Mg++ binding site [ion binding]; other site 1114970004472 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970004473 nucleotide binding region [chemical binding]; other site 1114970004474 ATP-binding site [chemical binding]; other site 1114970004475 Helicase associated domain (HA2); Region: HA2; cl04503 1114970004476 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1114970004477 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1114970004478 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 1114970004479 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1114970004480 dimer interface [polypeptide binding]; other site 1114970004481 active site 1114970004482 CoA binding pocket [chemical binding]; other site 1114970004483 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1114970004484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970004485 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970004486 DNA binding residues [nucleotide binding] 1114970004487 Putative zinc-finger; Region: zf-HC2; cl15806 1114970004488 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1114970004489 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 1114970004490 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970004491 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1114970004492 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1114970004493 amphipathic channel; other site 1114970004494 Asn-Pro-Ala signature motifs; other site 1114970004495 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114970004496 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114970004497 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1114970004498 Walker A/P-loop; other site 1114970004499 ATP binding site [chemical binding]; other site 1114970004500 Q-loop/lid; other site 1114970004501 ABC transporter signature motif; other site 1114970004502 Walker B; other site 1114970004503 D-loop; other site 1114970004504 H-loop/switch region; other site 1114970004505 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 1114970004506 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1114970004507 substrate binding site [chemical binding]; other site 1114970004508 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970004509 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970004510 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970004511 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970004512 Helix-turn-helix domains; Region: HTH; cl00088 1114970004513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970004514 dimerization interface [polypeptide binding]; other site 1114970004515 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970004516 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970004517 dimer interface [polypeptide binding]; other site 1114970004518 phosphorylation site [posttranslational modification] 1114970004519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970004520 ATP binding site [chemical binding]; other site 1114970004521 Mg2+ binding site [ion binding]; other site 1114970004522 G-X-G motif; other site 1114970004523 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970004524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970004525 active site 1114970004526 phosphorylation site [posttranslational modification] 1114970004527 intermolecular recognition site; other site 1114970004528 dimerization interface [polypeptide binding]; other site 1114970004529 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114970004530 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114970004531 helicase 45; Provisional; Region: PTZ00424 1114970004532 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114970004533 ATP binding site [chemical binding]; other site 1114970004534 Mg++ binding site [ion binding]; other site 1114970004535 motif III; other site 1114970004536 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970004537 nucleotide binding region [chemical binding]; other site 1114970004538 ATP-binding site [chemical binding]; other site 1114970004539 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1114970004540 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970004541 Surface antigen; Region: Bac_surface_Ag; cl03097 1114970004542 haemagglutination activity domain; Region: Haemagg_act; cl05436 1114970004543 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970004544 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 1114970004545 Transposase IS200 like; Region: Y1_Tnp; cl00848 1114970004546 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114970004547 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1114970004548 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1114970004549 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114970004550 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114970004551 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1114970004552 Na binding site [ion binding]; other site 1114970004553 putative substrate binding site [chemical binding]; other site 1114970004554 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1114970004555 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970004556 Helix-turn-helix domains; Region: HTH; cl00088 1114970004557 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1114970004558 putative dimerization interface [polypeptide binding]; other site 1114970004559 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1114970004560 Na binding site [ion binding]; other site 1114970004561 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114970004562 Na binding site [ion binding]; other site 1114970004563 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970004564 Arginase family; Region: Arginase; cl00306 1114970004565 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970004566 Helix-turn-helix domains; Region: HTH; cl00088 1114970004567 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970004568 dimerization interface [polypeptide binding]; other site 1114970004569 DTW domain; Region: DTW; cl01221 1114970004570 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1114970004571 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970004572 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970004573 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421 1114970004574 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1114970004575 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114970004576 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970004577 Walker A/P-loop; other site 1114970004578 ATP binding site [chemical binding]; other site 1114970004579 Q-loop/lid; other site 1114970004580 ABC transporter signature motif; other site 1114970004581 Walker B; other site 1114970004582 D-loop; other site 1114970004583 H-loop/switch region; other site 1114970004584 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1114970004585 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1114970004586 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1114970004587 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1114970004588 metal ion-dependent adhesion site (MIDAS); other site 1114970004589 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1114970004590 Protein of unknown function (DUF454); Region: DUF454; cl01063 1114970004591 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1114970004592 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1114970004593 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970004594 ATP binding site [chemical binding]; other site 1114970004595 putative Mg++ binding site [ion binding]; other site 1114970004596 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970004597 nucleotide binding region [chemical binding]; other site 1114970004598 ATP-binding site [chemical binding]; other site 1114970004599 RQC domain; Region: RQC; cl09632 1114970004600 HRDC domain; Region: HRDC; cl02578 1114970004601 transcriptional regulator SlyA; Provisional; Region: PRK03573 1114970004602 Helix-turn-helix domains; Region: HTH; cl00088 1114970004603 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1114970004604 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1114970004605 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1114970004606 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1114970004607 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1114970004608 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1114970004609 active site 1114970004610 nucleophile elbow; other site 1114970004611 Surface antigen; Region: Bac_surface_Ag; cl03097 1114970004612 Rdx family; Region: Rdx; cl01407 1114970004613 EamA-like transporter family; Region: EamA; cl01037 1114970004614 Cupin domain; Region: Cupin_2; cl09118 1114970004615 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970004616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970004617 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114970004618 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1114970004619 putative active site [active] 1114970004620 putative metal binding site [ion binding]; other site 1114970004621 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114970004622 Protein of unknown function (DUF962); Region: DUF962; cl01879 1114970004623 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970004624 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970004625 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970004626 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1114970004627 Cation transport protein; Region: TrkH; cl10514 1114970004628 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1114970004629 putative FMN binding site [chemical binding]; other site 1114970004630 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1114970004631 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970004632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970004633 homodimer interface [polypeptide binding]; other site 1114970004634 catalytic residue [active] 1114970004635 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 1114970004636 aromatic arch; other site 1114970004637 DCoH dimer interaction site [polypeptide binding]; other site 1114970004638 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1114970004639 DCoH tetramer interaction site [polypeptide binding]; other site 1114970004640 substrate binding site [chemical binding]; other site 1114970004641 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 1114970004642 cofactor binding site; other site 1114970004643 metal binding site [ion binding]; metal-binding site 1114970004644 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1114970004645 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1114970004646 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970004647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970004648 Walker A motif; other site 1114970004649 ATP binding site [chemical binding]; other site 1114970004650 Walker B motif; other site 1114970004651 arginine finger; other site 1114970004652 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1114970004653 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1114970004654 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114970004655 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1114970004656 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1114970004657 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114970004658 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 1114970004659 Flagellar L-ring protein; Region: FlgH; cl00905 1114970004660 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1114970004661 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1114970004662 Rod binding protein; Region: Rod-binding; cl01626 1114970004663 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1114970004664 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 1114970004665 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1114970004666 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114970004667 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717 1114970004668 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1114970004669 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1114970004670 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114970004671 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114970004672 active site 1114970004673 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970004674 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114970004675 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970004676 active site 1114970004677 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970004678 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1114970004679 substrate binding site; other site 1114970004680 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1114970004681 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1114970004682 NAD binding site [chemical binding]; other site 1114970004683 homotetramer interface [polypeptide binding]; other site 1114970004684 homodimer interface [polypeptide binding]; other site 1114970004685 substrate binding site [chemical binding]; other site 1114970004686 active site 1114970004687 Cupin domain; Region: Cupin_2; cl09118 1114970004688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970004689 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1114970004690 NAD(P) binding site [chemical binding]; other site 1114970004691 active site 1114970004692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970004693 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1114970004694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970004695 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970004696 active site 1114970004697 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970004698 active site 1114970004699 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1114970004700 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1114970004701 NAD(P) binding site [chemical binding]; other site 1114970004702 homodimer interface [polypeptide binding]; other site 1114970004703 substrate binding site [chemical binding]; other site 1114970004704 active site 1114970004705 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1114970004706 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1114970004707 inhibitor-cofactor binding pocket; inhibition site 1114970004708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970004709 catalytic residue [active] 1114970004710 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1114970004711 ligand binding site; other site 1114970004712 tetramer interface; other site 1114970004713 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1114970004714 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970004715 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114970004716 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970004717 pseudaminic acid synthase; Region: PseI; TIGR03586 1114970004718 NeuB family; Region: NeuB; cl00496 1114970004719 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1114970004720 NeuB binding interface [polypeptide binding]; other site 1114970004721 putative substrate binding site [chemical binding]; other site 1114970004722 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1114970004723 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1114970004724 dimer interface [polypeptide binding]; other site 1114970004725 active site 1114970004726 CoA binding pocket [chemical binding]; other site 1114970004727 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 1114970004728 flagellin; Provisional; Region: PRK12802 1114970004729 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1114970004730 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1114970004731 FlaG protein; Region: FlaG; cl00591 1114970004732 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1114970004733 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1114970004734 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1114970004735 Flagellar protein FliS; Region: FliS; cl00654 1114970004736 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970004737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1114970004738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970004739 Walker A motif; other site 1114970004740 ATP binding site [chemical binding]; other site 1114970004741 Walker B motif; other site 1114970004742 arginine finger; other site 1114970004743 Helix-turn-helix domains; Region: HTH; cl00088 1114970004744 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1114970004745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970004746 dimer interface [polypeptide binding]; other site 1114970004747 phosphorylation site [posttranslational modification] 1114970004748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970004749 ATP binding site [chemical binding]; other site 1114970004750 Mg2+ binding site [ion binding]; other site 1114970004751 G-X-G motif; other site 1114970004752 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970004753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970004754 active site 1114970004755 phosphorylation site [posttranslational modification] 1114970004756 intermolecular recognition site; other site 1114970004757 dimerization interface [polypeptide binding]; other site 1114970004758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970004759 Walker A motif; other site 1114970004760 ATP binding site [chemical binding]; other site 1114970004761 Walker B motif; other site 1114970004762 arginine finger; other site 1114970004763 Helix-turn-helix domains; Region: HTH; cl00088 1114970004764 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1114970004765 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1114970004766 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1114970004767 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1114970004768 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1114970004769 MgtE intracellular N domain; Region: MgtE_N; cl15244 1114970004770 FliG C-terminal domain; Region: FliG_C; pfam01706 1114970004771 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1114970004772 Flagellar assembly protein FliH; Region: FliH; pfam02108 1114970004773 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 1114970004774 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1114970004775 Walker A motif/ATP binding site; other site 1114970004776 Walker B motif; other site 1114970004777 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 1114970004778 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1114970004779 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1114970004780 anti sigma factor interaction site; other site 1114970004781 regulatory phosphorylation site [posttranslational modification]; other site 1114970004782 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970004783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970004784 active site 1114970004785 phosphorylation site [posttranslational modification] 1114970004786 intermolecular recognition site; other site 1114970004787 dimerization interface [polypeptide binding]; other site 1114970004788 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1114970004789 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1114970004790 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1114970004791 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970004792 putative binding surface; other site 1114970004793 active site 1114970004794 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 1114970004795 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1114970004796 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1114970004797 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1114970004798 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1114970004799 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1114970004800 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1114970004801 FliP family; Region: FliP; cl00593 1114970004802 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1114970004803 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1114970004804 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1114970004805 CcmE; Region: CcmE; cl00994 1114970004806 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1114970004807 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970004808 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1114970004809 active site 1114970004810 catalytic site [active] 1114970004811 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 1114970004812 FHIPEP family; Region: FHIPEP; pfam00771 1114970004813 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1114970004814 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970004815 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1114970004816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970004817 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1114970004818 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1114970004819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970004820 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114970004821 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970004822 DNA binding residues [nucleotide binding] 1114970004823 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1114970004824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970004825 active site 1114970004826 phosphorylation site [posttranslational modification] 1114970004827 intermolecular recognition site; other site 1114970004828 dimerization interface [polypeptide binding]; other site 1114970004829 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1114970004830 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970004831 putative binding surface; other site 1114970004832 active site 1114970004833 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1114970004834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970004835 ATP binding site [chemical binding]; other site 1114970004836 Mg2+ binding site [ion binding]; other site 1114970004837 G-X-G motif; other site 1114970004838 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1114970004839 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970004840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970004841 active site 1114970004842 phosphorylation site [posttranslational modification] 1114970004843 intermolecular recognition site; other site 1114970004844 dimerization interface [polypeptide binding]; other site 1114970004845 CheB methylesterase; Region: CheB_methylest; pfam01339 1114970004846 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1114970004847 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114970004848 flagellar motor protein MotD; Reviewed; Region: PRK09038 1114970004849 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1114970004850 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970004851 ligand binding site [chemical binding]; other site 1114970004852 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114970004853 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114970004854 P-loop; other site 1114970004855 Magnesium ion binding site [ion binding]; other site 1114970004856 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114970004857 Magnesium ion binding site [ion binding]; other site 1114970004858 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1114970004859 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1114970004860 putative CheA interaction surface; other site 1114970004861 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 1114970004862 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1114970004863 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 1114970004864 CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE...; Region: ABC_CcmA_heme_exporter; cd03231 1114970004865 Walker A/P-loop; other site 1114970004866 ATP binding site [chemical binding]; other site 1114970004867 ABC transporter; Region: ABC_tran; pfam00005 1114970004868 Q-loop/lid; other site 1114970004869 ABC transporter signature motif; other site 1114970004870 Walker B; other site 1114970004871 D-loop; other site 1114970004872 H-loop/switch region; other site 1114970004873 CcmB protein; Region: CcmB; cl01016 1114970004874 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1114970004875 Heme exporter protein D (CcmD); Region: CcmD; cl11475 1114970004876 CcmE; Region: CcmE; cl00994 1114970004877 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1114970004878 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1114970004879 catalytic residues [active] 1114970004880 central insert; other site 1114970004881 Cytochrome C biogenesis protein; Region: CcmH; cl01179 1114970004882 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1114970004883 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1114970004884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970004885 binding surface 1114970004886 TPR motif; other site 1114970004887 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1114970004888 Sulfatase; Region: Sulfatase; cl10460 1114970004889 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 1114970004890 short chain dehydrogenase; Provisional; Region: PRK05650 1114970004891 classical (c) SDRs; Region: SDR_c; cd05233 1114970004892 NAD(P) binding site [chemical binding]; other site 1114970004893 active site 1114970004894 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 1114970004895 Global regulator protein family; Region: CsrA; cl00670 1114970004896 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 1114970004897 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1114970004898 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1114970004899 putative oligomer interface [polypeptide binding]; other site 1114970004900 putative active site [active] 1114970004901 metal binding site [ion binding]; metal-binding site 1114970004902 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1114970004903 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970004904 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970004905 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1114970004906 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1114970004907 active site 1114970004908 dimer interface [polypeptide binding]; other site 1114970004909 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1114970004910 Ligand Binding Site [chemical binding]; other site 1114970004911 Molecular Tunnel; other site 1114970004912 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1114970004913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970004914 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1114970004915 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1114970004916 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1114970004917 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1114970004918 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970004919 dimer interface [polypeptide binding]; other site 1114970004920 active site 1114970004921 EamA-like transporter family; Region: EamA; cl01037 1114970004922 fumarate hydratase; Provisional; Region: PRK12425 1114970004923 Class II fumarases; Region: Fumarase_classII; cd01362 1114970004924 active site 1114970004925 tetramer interface [polypeptide binding]; other site 1114970004926 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 1114970004927 BolA-like protein; Region: BolA; cl00386 1114970004928 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1114970004929 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1114970004930 active site residue [active] 1114970004931 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1114970004932 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1114970004933 catalytic residues [active] 1114970004934 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114970004935 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114970004936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970004937 Walker A/P-loop; other site 1114970004938 ATP binding site [chemical binding]; other site 1114970004939 Q-loop/lid; other site 1114970004940 ABC transporter signature motif; other site 1114970004941 Walker B; other site 1114970004942 D-loop; other site 1114970004943 H-loop/switch region; other site 1114970004944 PAS domain S-box; Region: sensory_box; TIGR00229 1114970004945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970004946 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970004947 metal binding site [ion binding]; metal-binding site 1114970004948 active site 1114970004949 I-site; other site 1114970004950 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970004951 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1114970004952 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970004953 metal binding site [ion binding]; metal-binding site 1114970004954 active site 1114970004955 I-site; other site 1114970004956 short chain dehydrogenase; Provisional; Region: PRK08703 1114970004957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970004958 NAD(P) binding site [chemical binding]; other site 1114970004959 active site 1114970004960 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1114970004961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970004962 motif II; other site 1114970004963 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1114970004964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970004965 S-adenosylmethionine binding site [chemical binding]; other site 1114970004966 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1114970004967 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1114970004968 active site 1114970004969 putative substrate binding pocket [chemical binding]; other site 1114970004970 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1114970004971 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1114970004972 DNA gyrase subunit A; Validated; Region: PRK05560 1114970004973 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1114970004974 CAP-like domain; other site 1114970004975 active site 1114970004976 primary dimer interface [polypeptide binding]; other site 1114970004977 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114970004978 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114970004979 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114970004980 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114970004981 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114970004982 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114970004983 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1114970004984 homodimer interface [polypeptide binding]; other site 1114970004985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970004986 substrate-cofactor binding pocket; other site 1114970004987 catalytic residue [active] 1114970004988 Chorismate mutase type II; Region: CM_2; cl00693 1114970004989 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1114970004990 Prephenate dehydratase; Region: PDT; pfam00800 1114970004991 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1114970004992 putative L-Phe binding site [chemical binding]; other site 1114970004993 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1114970004994 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970004995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970004996 homodimer interface [polypeptide binding]; other site 1114970004997 catalytic residue [active] 1114970004998 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 1114970004999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005000 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1114970005001 hinge; other site 1114970005002 active site 1114970005003 cytidylate kinase; Provisional; Region: cmk; PRK00023 1114970005004 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1114970005005 CMP-binding site; other site 1114970005006 The sites determining sugar specificity; other site 1114970005007 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1114970005008 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1114970005009 RNA binding site [nucleotide binding]; other site 1114970005010 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1114970005011 RNA binding site [nucleotide binding]; other site 1114970005012 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 1114970005013 RNA binding site [nucleotide binding]; other site 1114970005014 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114970005015 RNA binding site [nucleotide binding]; other site 1114970005016 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114970005017 RNA binding site [nucleotide binding]; other site 1114970005018 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 1114970005019 RNA binding site [nucleotide binding]; other site 1114970005020 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114970005021 IHF dimer interface [polypeptide binding]; other site 1114970005022 IHF - DNA interface [nucleotide binding]; other site 1114970005023 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 1114970005024 Chain length determinant protein; Region: Wzz; cl15801 1114970005025 Chain length determinant protein; Region: Wzz; cl15801 1114970005026 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1114970005027 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1114970005028 active site 1114970005029 homodimer interface [polypeptide binding]; other site 1114970005030 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1114970005031 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114970005032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005033 MatE; Region: MatE; cl10513 1114970005034 O-Antigen ligase; Region: Wzy_C; cl04850 1114970005035 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 1114970005036 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114970005037 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1114970005038 putative NAD(P) binding site [chemical binding]; other site 1114970005039 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114970005040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005041 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1114970005042 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 1114970005043 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970005044 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1114970005045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005046 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 1114970005047 putative catalytic motif [active] 1114970005048 OpgC protein; Region: OpgC_C; cl00792 1114970005049 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1114970005050 OpgC protein; Region: OpgC_C; cl00792 1114970005051 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1114970005052 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1114970005053 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1114970005054 NAD(P) binding site [chemical binding]; other site 1114970005055 homodimer interface [polypeptide binding]; other site 1114970005056 substrate binding site [chemical binding]; other site 1114970005057 active site 1114970005058 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1114970005059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970005060 DNA-binding site [nucleotide binding]; DNA binding site 1114970005061 FCD domain; Region: FCD; cl11656 1114970005062 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1114970005063 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 1114970005064 ethanolamine permease; Region: 2A0305; TIGR00908 1114970005065 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 1114970005066 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1114970005067 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114970005068 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114970005069 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1114970005070 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1114970005071 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1114970005072 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1114970005073 Ligand Binding Site [chemical binding]; other site 1114970005074 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1114970005075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970005076 dimer interface [polypeptide binding]; other site 1114970005077 phosphorylation site [posttranslational modification] 1114970005078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005079 ATP binding site [chemical binding]; other site 1114970005080 Mg2+ binding site [ion binding]; other site 1114970005081 G-X-G motif; other site 1114970005082 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1114970005083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005084 active site 1114970005085 phosphorylation site [posttranslational modification] 1114970005086 intermolecular recognition site; other site 1114970005087 dimerization interface [polypeptide binding]; other site 1114970005088 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970005089 DNA binding site [nucleotide binding] 1114970005090 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1114970005091 active site 1114970005092 nucleophile elbow; other site 1114970005093 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1114970005094 CHAD domain; Region: CHAD; cl10506 1114970005095 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1114970005096 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1114970005097 active site 1114970005098 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1114970005099 active site 2 [active] 1114970005100 active site 1 [active] 1114970005101 Terminase small subunit; Region: Terminase_2; cl01513 1114970005102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970005103 dimerization interface [polypeptide binding]; other site 1114970005104 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970005105 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970005106 dimer interface [polypeptide binding]; other site 1114970005107 putative CheW interface [polypeptide binding]; other site 1114970005108 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1114970005109 active site 1114970005110 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 1114970005111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 1114970005112 substrate binding pocket [chemical binding]; other site 1114970005113 membrane-bound complex binding site; other site 1114970005114 hinge residues; other site 1114970005115 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1114970005116 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970005117 catalytic residue [active] 1114970005118 DoxX; Region: DoxX; cl00976 1114970005119 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1114970005120 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1114970005121 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114970005122 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1114970005123 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1114970005124 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1114970005125 Walker A/P-loop; other site 1114970005126 ATP binding site [chemical binding]; other site 1114970005127 Q-loop/lid; other site 1114970005128 ABC transporter signature motif; other site 1114970005129 Walker B; other site 1114970005130 D-loop; other site 1114970005131 H-loop/switch region; other site 1114970005132 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1114970005133 active site 1114970005134 catalytic triad [active] 1114970005135 oxyanion hole [active] 1114970005136 switch loop; other site 1114970005137 L,D-transpeptidase; Provisional; Region: PRK10260 1114970005138 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1114970005139 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970005140 NeuB family; Region: NeuB; cl00496 1114970005141 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1114970005142 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 1114970005143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005144 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1114970005145 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 1114970005146 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970005147 Ligand Binding Site [chemical binding]; other site 1114970005148 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1114970005149 Helix-turn-helix domains; Region: HTH; cl00088 1114970005150 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1114970005151 substrate binding site [chemical binding]; other site 1114970005152 dimerization interface [polypeptide binding]; other site 1114970005153 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114970005154 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823 1114970005155 elongation factor P; Validated; Region: PRK00529 1114970005156 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1114970005157 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114970005158 RNA binding site [nucleotide binding]; other site 1114970005159 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1114970005160 RNA binding site [nucleotide binding]; other site 1114970005161 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970005162 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114970005163 substrate binding pocket [chemical binding]; other site 1114970005164 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970005165 OsmC-like protein; Region: OsmC; cl00767 1114970005166 Helix-turn-helix domains; Region: HTH; cl00088 1114970005167 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114970005168 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1114970005169 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970005170 Helix-turn-helix domains; Region: HTH; cl00088 1114970005171 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970005172 dimerization interface [polypeptide binding]; other site 1114970005173 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 1114970005174 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1114970005175 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 1114970005176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970005177 helicase 45; Provisional; Region: PTZ00424 1114970005178 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114970005179 ATP binding site [chemical binding]; other site 1114970005180 Mg++ binding site [ion binding]; other site 1114970005181 motif III; other site 1114970005182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970005183 nucleotide binding region [chemical binding]; other site 1114970005184 ATP-binding site [chemical binding]; other site 1114970005185 DbpA RNA binding domain; Region: DbpA; pfam03880 1114970005186 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1114970005187 putative active site [active] 1114970005188 metal binding site [ion binding]; metal-binding site 1114970005189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970005190 Peptidase family M48; Region: Peptidase_M48; cl12018 1114970005191 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1114970005192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970005193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970005194 homodimer interface [polypeptide binding]; other site 1114970005195 catalytic residue [active] 1114970005196 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 1114970005197 SelR domain; Region: SelR; pfam01641 1114970005198 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1114970005199 catalytic residues [active] 1114970005200 dimer interface [polypeptide binding]; other site 1114970005201 Helix-turn-helix domains; Region: HTH; cl00088 1114970005202 two component system sensor kinase SsrA; Provisional; Region: PRK15347 1114970005203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970005204 dimer interface [polypeptide binding]; other site 1114970005205 phosphorylation site [posttranslational modification] 1114970005206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005207 ATP binding site [chemical binding]; other site 1114970005208 Mg2+ binding site [ion binding]; other site 1114970005209 G-X-G motif; other site 1114970005210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005211 active site 1114970005212 phosphorylation site [posttranslational modification] 1114970005213 intermolecular recognition site; other site 1114970005214 dimerization interface [polypeptide binding]; other site 1114970005215 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1114970005216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970005217 Walker A motif; other site 1114970005218 ATP binding site [chemical binding]; other site 1114970005219 Walker B motif; other site 1114970005220 GAF domain; Region: GAF; cl15785 1114970005221 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970005222 GAF domain; Region: GAF; cl15785 1114970005223 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1114970005224 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114970005225 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1114970005226 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970005227 substrate binding pocket [chemical binding]; other site 1114970005228 membrane-bound complex binding site; other site 1114970005229 hinge residues; other site 1114970005230 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970005231 substrate binding pocket [chemical binding]; other site 1114970005232 membrane-bound complex binding site; other site 1114970005233 hinge residues; other site 1114970005234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970005235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970005236 dimer interface [polypeptide binding]; other site 1114970005237 phosphorylation site [posttranslational modification] 1114970005238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005239 ATP binding site [chemical binding]; other site 1114970005240 Mg2+ binding site [ion binding]; other site 1114970005241 G-X-G motif; other site 1114970005242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005243 active site 1114970005244 phosphorylation site [posttranslational modification] 1114970005245 intermolecular recognition site; other site 1114970005246 dimerization interface [polypeptide binding]; other site 1114970005247 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1114970005248 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970005249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005250 active site 1114970005251 phosphorylation site [posttranslational modification] 1114970005252 intermolecular recognition site; other site 1114970005253 dimerization interface [polypeptide binding]; other site 1114970005254 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970005255 DNA binding residues [nucleotide binding] 1114970005256 dimerization interface [polypeptide binding]; other site 1114970005257 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1114970005258 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114970005259 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1114970005260 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 1114970005261 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1114970005262 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1114970005263 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1114970005264 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1114970005265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005266 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114970005267 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1114970005268 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1114970005269 probable active site [active] 1114970005270 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1114970005271 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1114970005272 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1114970005273 GTP binding site; other site 1114970005274 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1114970005275 MPT binding site; other site 1114970005276 trimer interface [polypeptide binding]; other site 1114970005277 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1114970005278 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1114970005279 dimer interface [polypeptide binding]; other site 1114970005280 putative functional site; other site 1114970005281 putative MPT binding site; other site 1114970005282 lipid kinase; Reviewed; Region: PRK13054 1114970005283 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1114970005284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005285 active site 1114970005286 phosphorylation site [posttranslational modification] 1114970005287 intermolecular recognition site; other site 1114970005288 dimerization interface [polypeptide binding]; other site 1114970005289 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970005290 DNA binding residues [nucleotide binding] 1114970005291 dimerization interface [polypeptide binding]; other site 1114970005292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114970005293 Histidine kinase; Region: HisKA_3; pfam07730 1114970005294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005295 ATP binding site [chemical binding]; other site 1114970005296 Mg2+ binding site [ion binding]; other site 1114970005297 G-X-G motif; other site 1114970005298 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1114970005299 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970005300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005301 active site 1114970005302 phosphorylation site [posttranslational modification] 1114970005303 intermolecular recognition site; other site 1114970005304 dimerization interface [polypeptide binding]; other site 1114970005305 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1114970005306 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1114970005307 MOSC domain; Region: MOSC; pfam03473 1114970005308 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 1114970005309 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1114970005310 active site 1114970005311 catalytic site [active] 1114970005312 substrate binding site [chemical binding]; other site 1114970005313 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1114970005314 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970005315 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970005316 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1114970005317 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970005318 carboxyltransferase (CT) interaction site; other site 1114970005319 biotinylation site [posttranslational modification]; other site 1114970005320 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970005321 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970005322 active site 1114970005323 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1114970005324 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114970005325 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114970005326 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1114970005327 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970005328 Helix-turn-helix domains; Region: HTH; cl00088 1114970005329 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1114970005330 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970005331 substrate binding pocket [chemical binding]; other site 1114970005332 membrane-bound complex binding site; other site 1114970005333 hinge residues; other site 1114970005334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1114970005335 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1114970005336 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1114970005337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970005338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970005339 peptide synthase; Validated; Region: PRK05691 1114970005340 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005341 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005342 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005343 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970005344 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005345 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005346 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005347 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970005348 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114970005349 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005350 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005351 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005352 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970005353 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1114970005354 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970005355 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1114970005356 dimerization domain [polypeptide binding]; other site 1114970005357 dimer interface [polypeptide binding]; other site 1114970005358 catalytic residues [active] 1114970005359 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114970005360 catalytic residues [active] 1114970005361 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1114970005362 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1114970005363 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1114970005364 DsbD alpha interface [polypeptide binding]; other site 1114970005365 catalytic residues [active] 1114970005366 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1114970005367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005368 active site 1114970005369 phosphorylation site [posttranslational modification] 1114970005370 intermolecular recognition site; other site 1114970005371 dimerization interface [polypeptide binding]; other site 1114970005372 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970005373 DNA binding site [nucleotide binding] 1114970005374 sensor protein QseC; Provisional; Region: PRK10337 1114970005375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970005376 dimer interface [polypeptide binding]; other site 1114970005377 phosphorylation site [posttranslational modification] 1114970005378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005379 ATP binding site [chemical binding]; other site 1114970005380 G-X-G motif; other site 1114970005381 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 1114970005382 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970005383 inhibitor-cofactor binding pocket; inhibition site 1114970005384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970005385 catalytic residue [active] 1114970005386 MbtH-like protein; Region: MbtH; cl01279 1114970005387 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970005388 Helix-turn-helix domains; Region: HTH; cl00088 1114970005389 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970005390 putative effector binding pocket; other site 1114970005391 dimerization interface [polypeptide binding]; other site 1114970005392 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1114970005393 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1114970005394 potential catalytic triad [active] 1114970005395 conserved cys residue [active] 1114970005396 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 1114970005397 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1114970005398 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1114970005399 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1114970005400 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1114970005401 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970005402 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1114970005403 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1114970005404 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1114970005405 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1114970005406 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970005407 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970005408 DNA binding residues [nucleotide binding] 1114970005409 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1114970005410 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970005411 ligand binding site [chemical binding]; other site 1114970005412 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1114970005413 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1114970005414 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1114970005415 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1114970005416 [4Fe-4S] binding site [ion binding]; other site 1114970005417 molybdopterin cofactor binding site; other site 1114970005418 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1114970005419 molybdopterin cofactor binding site; other site 1114970005420 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1114970005421 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1114970005422 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1114970005423 [2Fe-2S] cluster binding site [ion binding]; other site 1114970005424 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1114970005425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970005426 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1114970005427 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1114970005428 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114970005429 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1114970005430 active site 1114970005431 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1114970005432 active site 1114970005433 ATP binding site [chemical binding]; other site 1114970005434 substrate binding site [chemical binding]; other site 1114970005435 activation loop (A-loop); other site 1114970005436 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1114970005437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970005438 putative substrate translocation pore; other site 1114970005439 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1114970005440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005441 active site 1114970005442 phosphorylation site [posttranslational modification] 1114970005443 intermolecular recognition site; other site 1114970005444 dimerization interface [polypeptide binding]; other site 1114970005445 ANTAR domain; Region: ANTAR; cl04297 1114970005446 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1114970005447 NMT1-like family; Region: NMT1_2; cl15260 1114970005448 transcriptional regulator InvF; Provisional; Region: PRK15340 1114970005449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970005450 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 1114970005451 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970005452 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970005453 type III secretion system regulator InvE; Provisional; Region: PRK15338 1114970005454 HrpJ-like domain; Region: HrpJ; cl15454 1114970005455 type III secretion system protein InvA; Provisional; Region: PRK15337 1114970005456 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 1114970005457 ATP synthase SpaL; Validated; Region: PRK08149 1114970005458 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1114970005459 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970005460 Walker A motif; other site 1114970005461 ATP binding site [chemical binding]; other site 1114970005462 Walker B motif; other site 1114970005463 type III secretion system protein SpaO; Validated; Region: PRK08158 1114970005464 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1114970005465 FliP family; Region: FliP; cl00593 1114970005466 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1114970005467 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1114970005468 type III secretion system protein SpaS; Validated; Region: PRK08156 1114970005469 chaperone protein SicA; Provisional; Region: PRK15331 1114970005470 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1114970005471 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1114970005472 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 1114970005473 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; cl10712 1114970005474 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 1114970005475 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970005476 invasion protein regulator; Provisional; Region: PRK12370 1114970005477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970005478 DNA binding site [nucleotide binding] 1114970005479 TolB amino-terminal domain; Region: TolB_N; cl00639 1114970005480 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1114970005481 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970005482 catalytic residue [active] 1114970005483 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 1114970005484 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 1114970005485 Type III secretion needle MxiH like; Region: MxiH; cl09641 1114970005486 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 1114970005487 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1114970005488 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 1114970005489 invasion protein OrgB; Provisional; Region: PRK15322 1114970005490 Helix-turn-helix domains; Region: HTH; cl00088 1114970005491 Integrase core domain; Region: rve_3; cl15866 1114970005492 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1114970005493 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1114970005494 DNA binding residues [nucleotide binding] 1114970005495 dimer interface [polypeptide binding]; other site 1114970005496 [2Fe-2S] cluster binding site [ion binding]; other site 1114970005497 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114970005498 LysE type translocator; Region: LysE; cl00565 1114970005499 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1114970005500 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970005501 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970005502 catalytic residue [active] 1114970005503 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1114970005504 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1114970005505 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1114970005506 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1114970005507 active site 1114970005508 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1114970005509 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1114970005510 putative catalytic residue [active] 1114970005511 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 1114970005512 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1114970005513 putative NAD(P) binding site [chemical binding]; other site 1114970005514 active site 1114970005515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970005516 Helix-turn-helix domains; Region: HTH; cl00088 1114970005517 threonine and homoserine efflux system; Provisional; Region: PRK10532 1114970005518 EamA-like transporter family; Region: EamA; cl01037 1114970005519 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 1114970005520 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 1114970005521 putative hydrophobic ligand binding site [chemical binding]; other site 1114970005522 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1114970005523 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970005524 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970005525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970005526 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1114970005527 classical (c) SDRs; Region: SDR_c; cd05233 1114970005528 NAD(P) binding site [chemical binding]; other site 1114970005529 active site 1114970005530 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 1114970005531 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1114970005532 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1114970005533 conserved cys residue [active] 1114970005534 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1114970005535 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970005536 conserved cys residue [active] 1114970005537 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970005538 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970005539 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970005540 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114970005541 MULE transposase domain; Region: MULE; pfam10551 1114970005542 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1114970005543 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1114970005544 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1114970005545 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1114970005546 NAD binding site [chemical binding]; other site 1114970005547 homodimer interface [polypeptide binding]; other site 1114970005548 active site 1114970005549 SCP-2 sterol transfer family; Region: SCP2; cl01225 1114970005550 JmjC domain, hydroxylase; Region: JmjC; cl15814 1114970005551 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1114970005552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970005553 S-adenosylmethionine binding site [chemical binding]; other site 1114970005554 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1114970005555 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970005556 peptide synthase; Provisional; Region: PRK12316 1114970005557 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005558 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005559 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970005560 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114970005561 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005562 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970005563 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114970005564 peptide synthase; Provisional; Region: PRK12316 1114970005565 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005566 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005567 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005568 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970005569 peptide synthase; Provisional; Region: PRK12467 1114970005570 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005571 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005572 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005573 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970005574 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114970005575 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005576 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005577 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005578 peptide synthase; Provisional; Region: PRK12316 1114970005579 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114970005580 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005581 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005582 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970005583 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005584 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1114970005585 Condensation domain; Region: Condensation; pfam00668 1114970005586 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114970005587 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005588 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1114970005589 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970005590 Secretin and TonB N terminus short domain; Region: STN; cl06624 1114970005591 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1114970005592 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970005593 N-terminal plug; other site 1114970005594 ligand-binding site [chemical binding]; other site 1114970005595 peptide synthase; Provisional; Region: PRK12467 1114970005596 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005597 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005598 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970005599 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970005600 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 1114970005601 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114970005602 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 1114970005603 Walker A/P-loop; other site 1114970005604 ATP binding site [chemical binding]; other site 1114970005605 Q-loop/lid; other site 1114970005606 ABC transporter signature motif; other site 1114970005607 Walker B; other site 1114970005608 D-loop; other site 1114970005609 H-loop/switch region; other site 1114970005610 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 1114970005611 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1114970005612 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970005613 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970005614 catalytic residue [active] 1114970005615 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1114970005616 active site 1114970005617 dimer interface [polypeptide binding]; other site 1114970005618 Colicin-E5 Imm protein; Region: ImmE5; pfam11480 1114970005619 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970005620 RHS protein; Region: RHS; pfam03527 1114970005621 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970005622 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970005623 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1114970005624 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1114970005625 Walker A/P-loop; other site 1114970005626 ATP binding site [chemical binding]; other site 1114970005627 Q-loop/lid; other site 1114970005628 ABC transporter signature motif; other site 1114970005629 Walker B; other site 1114970005630 D-loop; other site 1114970005631 H-loop/switch region; other site 1114970005632 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114970005633 FtsX-like permease family; Region: FtsX; cl15850 1114970005634 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1114970005635 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970005636 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970005637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970005638 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1114970005639 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970005640 DNA binding residues [nucleotide binding] 1114970005641 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1114970005642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005643 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970005644 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970005645 substrate binding pocket [chemical binding]; other site 1114970005646 membrane-bound complex binding site; other site 1114970005647 hinge residues; other site 1114970005648 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970005649 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970005650 substrate binding pocket [chemical binding]; other site 1114970005651 membrane-bound complex binding site; other site 1114970005652 hinge residues; other site 1114970005653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970005654 dimer interface [polypeptide binding]; other site 1114970005655 phosphorylation site [posttranslational modification] 1114970005656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005657 ATP binding site [chemical binding]; other site 1114970005658 Mg2+ binding site [ion binding]; other site 1114970005659 G-X-G motif; other site 1114970005660 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970005661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005662 active site 1114970005663 phosphorylation site [posttranslational modification] 1114970005664 intermolecular recognition site; other site 1114970005665 dimerization interface [polypeptide binding]; other site 1114970005666 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1114970005667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1114970005668 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970005669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005670 active site 1114970005671 phosphorylation site [posttranslational modification] 1114970005672 intermolecular recognition site; other site 1114970005673 dimerization interface [polypeptide binding]; other site 1114970005674 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970005675 DNA binding residues [nucleotide binding] 1114970005676 dimerization interface [polypeptide binding]; other site 1114970005677 Pirin-related protein [General function prediction only]; Region: COG1741 1114970005678 Cupin domain; Region: Cupin_2; cl09118 1114970005679 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1114970005680 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114970005681 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970005682 ligand binding site [chemical binding]; other site 1114970005683 flexible hinge region; other site 1114970005684 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970005685 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1114970005686 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970005687 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970005688 DNA binding residues [nucleotide binding] 1114970005689 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970005690 FecR protein; Region: FecR; pfam04773 1114970005691 Secretin and TonB N terminus short domain; Region: STN; cl06624 1114970005692 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1114970005693 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970005694 N-terminal plug; other site 1114970005695 ligand-binding site [chemical binding]; other site 1114970005696 diaminopimelate epimerase; Provisional; Region: PRK13577 1114970005697 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114970005698 cytosine deaminase; Provisional; Region: PRK09230 1114970005699 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1114970005700 active site 1114970005701 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114970005702 Na binding site [ion binding]; other site 1114970005703 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970005704 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1114970005705 active site 1114970005706 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1114970005707 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1114970005708 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1114970005709 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970005710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005711 active site 1114970005712 phosphorylation site [posttranslational modification] 1114970005713 intermolecular recognition site; other site 1114970005714 dimerization interface [polypeptide binding]; other site 1114970005715 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970005716 DNA binding site [nucleotide binding] 1114970005717 sensor protein PhoQ; Provisional; Region: PRK10815 1114970005718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005719 ATP binding site [chemical binding]; other site 1114970005720 G-X-G motif; other site 1114970005721 Predicted permease [General function prediction only]; Region: COG2056 1114970005722 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1114970005723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 1114970005724 Cache domain; Region: Cache_2; cl07034 1114970005725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970005726 dimerization interface [polypeptide binding]; other site 1114970005727 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970005728 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970005729 dimer interface [polypeptide binding]; other site 1114970005730 putative CheW interface [polypeptide binding]; other site 1114970005731 putative protease; Provisional; Region: PRK15452 1114970005732 Peptidase family U32; Region: Peptidase_U32; cl03113 1114970005733 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114970005734 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1114970005735 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1114970005736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970005737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970005738 homodimer interface [polypeptide binding]; other site 1114970005739 catalytic residue [active] 1114970005740 excinuclease ABC subunit B; Provisional; Region: PRK05298 1114970005741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970005742 ATP binding site [chemical binding]; other site 1114970005743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970005744 nucleotide binding region [chemical binding]; other site 1114970005745 ATP-binding site [chemical binding]; other site 1114970005746 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1114970005747 UvrB/uvrC motif; Region: UVR; pfam02151 1114970005748 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1114970005749 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1114970005750 active site 1114970005751 HIGH motif; other site 1114970005752 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1114970005753 active site 1114970005754 KMSKS motif; other site 1114970005755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970005756 Helix-turn-helix domains; Region: HTH; cl00088 1114970005757 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1114970005758 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970005759 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114970005760 active site 1114970005761 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1114970005762 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1114970005763 FMN binding site [chemical binding]; other site 1114970005764 active site 1114970005765 catalytic residues [active] 1114970005766 substrate binding site [chemical binding]; other site 1114970005767 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1114970005768 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1114970005769 putative dimer interface [polypeptide binding]; other site 1114970005770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970005771 PAS fold; Region: PAS_3; pfam08447 1114970005772 putative active site [active] 1114970005773 heme pocket [chemical binding]; other site 1114970005774 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970005775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970005776 putative active site [active] 1114970005777 heme pocket [chemical binding]; other site 1114970005778 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1114970005779 PAS domain S-box; Region: sensory_box; TIGR00229 1114970005780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970005781 putative active site [active] 1114970005782 heme pocket [chemical binding]; other site 1114970005783 PAS domain S-box; Region: sensory_box; TIGR00229 1114970005784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970005785 putative active site [active] 1114970005786 heme pocket [chemical binding]; other site 1114970005787 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970005788 metal binding site [ion binding]; metal-binding site 1114970005789 active site 1114970005790 I-site; other site 1114970005791 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970005792 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970005793 Helix-turn-helix domains; Region: HTH; cl00088 1114970005794 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970005795 dimerization interface [polypeptide binding]; other site 1114970005796 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1114970005797 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1114970005798 substrate binding site [chemical binding]; other site 1114970005799 ligand binding site [chemical binding]; other site 1114970005800 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1114970005801 substrate binding site [chemical binding]; other site 1114970005802 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114970005803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970005804 S-adenosylmethionine binding site [chemical binding]; other site 1114970005805 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114970005806 tartrate dehydrogenase; Provisional; Region: PRK08194 1114970005807 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1114970005808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005809 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1114970005810 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 1114970005811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005812 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1114970005813 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1114970005814 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1114970005815 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1114970005816 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1114970005817 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1114970005818 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1114970005819 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1114970005820 dimerization interface 3.5A [polypeptide binding]; other site 1114970005821 active site 1114970005822 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 1114970005823 active site 1114970005824 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1114970005825 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114970005826 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1114970005827 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114970005828 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114970005829 Sporulation related domain; Region: SPOR; cl10051 1114970005830 Colicin V production protein; Region: Colicin_V; cl00567 1114970005831 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1114970005832 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1114970005833 active site 1114970005834 tetramer interface [polypeptide binding]; other site 1114970005835 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970005836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1114970005837 active site 1114970005838 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1114970005839 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1114970005840 homodimer interface [polypeptide binding]; other site 1114970005841 substrate-cofactor binding pocket; other site 1114970005842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970005843 catalytic residue [active] 1114970005844 oxidoreductase; Validated; Region: PRK05717 1114970005845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005846 NAD(P) binding site [chemical binding]; other site 1114970005847 active site 1114970005848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005849 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970005850 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1114970005851 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cd00065 1114970005852 Zn binding sites [ion binding]; other site 1114970005853 phosphatidylinositol 3-phosphate binding site [chemical binding]; other site 1114970005854 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970005855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970005856 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1114970005857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970005858 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1114970005859 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 1114970005860 AAA domain; Region: AAA_33; pfam13671 1114970005861 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970005862 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1114970005863 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1114970005864 conserved cys residue [active] 1114970005865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 1114970005866 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 1114970005867 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970005868 Helix-turn-helix domains; Region: HTH; cl00088 1114970005869 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970005870 dimerization interface [polypeptide binding]; other site 1114970005871 substrate binding pocket [chemical binding]; other site 1114970005872 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1114970005873 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1114970005874 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114970005875 protein binding site [polypeptide binding]; other site 1114970005876 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1114970005877 FRG domain; Region: FRG; cl07460 1114970005878 AzlC protein; Region: AzlC; cl00570 1114970005879 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114970005880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970005881 putative substrate translocation pore; other site 1114970005882 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1114970005883 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1114970005884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970005885 Walker A motif; other site 1114970005886 ATP binding site [chemical binding]; other site 1114970005887 Walker B motif; other site 1114970005888 arginine finger; other site 1114970005889 Helix-turn-helix domains; Region: HTH; cl00088 1114970005890 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1114970005891 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 1114970005892 Walker A/P-loop; other site 1114970005893 ATP binding site [chemical binding]; other site 1114970005894 Q-loop/lid; other site 1114970005895 ABC transporter signature motif; other site 1114970005896 Walker B; other site 1114970005897 D-loop; other site 1114970005898 H-loop/switch region; other site 1114970005899 TOBE domain; Region: TOBE_2; cl01440 1114970005900 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1114970005901 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 1114970005902 Walker A/P-loop; other site 1114970005903 ATP binding site [chemical binding]; other site 1114970005904 Q-loop/lid; other site 1114970005905 ABC transporter signature motif; other site 1114970005906 Walker B; other site 1114970005907 D-loop; other site 1114970005908 H-loop/switch region; other site 1114970005909 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1114970005910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970005911 putative PBP binding loops; other site 1114970005912 dimer interface [polypeptide binding]; other site 1114970005913 ABC-ATPase subunit interface; other site 1114970005914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970005915 dimer interface [polypeptide binding]; other site 1114970005916 conserved gate region; other site 1114970005917 putative PBP binding loops; other site 1114970005918 ABC-ATPase subunit interface; other site 1114970005919 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 1114970005920 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114970005921 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970005922 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1114970005923 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1114970005924 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1114970005925 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970005926 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1114970005927 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114970005928 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1114970005929 putative metal binding site [ion binding]; other site 1114970005930 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1114970005931 putative active site [active] 1114970005932 putative metal binding site [ion binding]; other site 1114970005933 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 1114970005934 DXD motif; other site 1114970005935 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1114970005936 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970005937 active site 1114970005938 O-Antigen ligase; Region: Wzy_C; cl04850 1114970005939 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1114970005940 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970005941 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1114970005942 Chain length determinant protein; Region: Wzz; cl15801 1114970005943 Chain length determinant protein; Region: Wzz; cl15801 1114970005944 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1114970005945 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1114970005946 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1114970005947 SLBB domain; Region: SLBB; pfam10531 1114970005948 exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1114970005949 Bacterial sugar transferase; Region: Bac_transf; cl00939 1114970005950 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970005951 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1114970005952 putative NAD(P) binding site [chemical binding]; other site 1114970005953 active site 1114970005954 putative substrate binding site [chemical binding]; other site 1114970005955 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1114970005956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005957 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114970005958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005959 Sulfatase; Region: Sulfatase; cl10460 1114970005960 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114970005961 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1114970005962 Walker A/P-loop; other site 1114970005963 ATP binding site [chemical binding]; other site 1114970005964 Q-loop/lid; other site 1114970005965 ABC transporter signature motif; other site 1114970005966 Walker B; other site 1114970005967 D-loop; other site 1114970005968 H-loop/switch region; other site 1114970005969 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1114970005970 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114970005971 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1114970005972 Protein of unknown function (DUF796); Region: DUF796; cl01226 1114970005973 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 1114970005974 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 1114970005975 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1114970005976 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114970005977 Cysteine-rich domain; Region: CCG; pfam02754 1114970005978 Cysteine-rich domain; Region: CCG; pfam02754 1114970005979 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1114970005980 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970005981 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1114970005982 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970005983 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970005984 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970005985 MASE2 domain; Region: MASE2; pfam05230 1114970005986 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970005987 metal binding site [ion binding]; metal-binding site 1114970005988 active site 1114970005989 I-site; other site 1114970005990 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1114970005991 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1114970005992 metal binding site [ion binding]; metal-binding site 1114970005993 dimer interface [polypeptide binding]; other site 1114970005994 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970005995 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970005996 ligand binding site [chemical binding]; other site 1114970005997 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1114970005998 putative catalytic site [active] 1114970005999 putative phosphate binding site [ion binding]; other site 1114970006000 active site 1114970006001 metal binding site A [ion binding]; metal-binding site 1114970006002 DNA binding site [nucleotide binding] 1114970006003 putative AP binding site [nucleotide binding]; other site 1114970006004 putative metal binding site B [ion binding]; other site 1114970006005 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970006006 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1114970006007 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970006008 Surface antigen; Region: Bac_surface_Ag; cl03097 1114970006009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1114970006010 Family of unknown function (DUF490); Region: DUF490; pfam04357 1114970006011 Helix-turn-helix domains; Region: HTH; cl00088 1114970006012 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970006013 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970006014 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1114970006015 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970006016 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970006017 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1114970006018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970006019 putative substrate translocation pore; other site 1114970006020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970006021 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114970006022 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1114970006023 putative active site [active] 1114970006024 putative metal binding site [ion binding]; other site 1114970006025 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 1114970006026 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1114970006027 substrate binding site [chemical binding]; other site 1114970006028 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1114970006029 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114970006030 active site 1114970006031 HIGH motif; other site 1114970006032 nucleotide binding site [chemical binding]; other site 1114970006033 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1114970006034 KMSKS motif; other site 1114970006035 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1114970006036 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1114970006037 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1114970006038 active site 1114970006039 HIGH motif; other site 1114970006040 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1114970006041 KMSKS motif; other site 1114970006042 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1114970006043 tRNA binding surface [nucleotide binding]; other site 1114970006044 anticodon binding site; other site 1114970006045 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 1114970006046 Global regulator protein family; Region: CsrA; cl00670 1114970006047 Endonuclease I; Region: Endonuclease_1; cl01003 1114970006048 DNA-specific endonuclease I; Provisional; Region: PRK15137 1114970006049 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 1114970006050 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1114970006051 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1114970006052 ligand binding site [chemical binding]; other site 1114970006053 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1114970006054 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 1114970006055 Walker A/P-loop; other site 1114970006056 ATP binding site [chemical binding]; other site 1114970006057 Q-loop/lid; other site 1114970006058 ABC transporter signature motif; other site 1114970006059 Walker B; other site 1114970006060 D-loop; other site 1114970006061 H-loop/switch region; other site 1114970006062 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1114970006063 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114970006064 TM-ABC transporter signature motif; other site 1114970006065 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970006066 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970006067 DNA binding site [nucleotide binding] 1114970006068 domain linker motif; other site 1114970006069 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1114970006070 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114970006071 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1114970006072 substrate binding site [chemical binding]; other site 1114970006073 dimer interface [polypeptide binding]; other site 1114970006074 ATP binding site [chemical binding]; other site 1114970006075 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1114970006076 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1114970006077 active site 1114970006078 tetramer interface [polypeptide binding]; other site 1114970006079 Potato inhibitor I family; Region: potato_inhibit; cl15459 1114970006080 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1114970006081 DNA-binding site [nucleotide binding]; DNA binding site 1114970006082 RNA-binding motif; other site 1114970006083 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1114970006084 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1114970006085 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1114970006086 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1114970006087 active site 1114970006088 dimer interface [polypeptide binding]; other site 1114970006089 motif 1; other site 1114970006090 motif 2; other site 1114970006091 motif 3; other site 1114970006092 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1114970006093 anticodon binding site; other site 1114970006094 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1114970006095 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1114970006096 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1114970006097 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 1114970006098 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1114970006099 23S rRNA binding site [nucleotide binding]; other site 1114970006100 L21 binding site [polypeptide binding]; other site 1114970006101 L13 binding site [polypeptide binding]; other site 1114970006102 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1114970006103 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1114970006104 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1114970006105 dimer interface [polypeptide binding]; other site 1114970006106 motif 1; other site 1114970006107 active site 1114970006108 motif 2; other site 1114970006109 motif 3; other site 1114970006110 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1114970006111 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1114970006112 putative tRNA-binding site [nucleotide binding]; other site 1114970006113 B3/4 domain; Region: B3_4; cl11458 1114970006114 tRNA synthetase B5 domain; Region: B5; cl08394 1114970006115 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1114970006116 dimer interface [polypeptide binding]; other site 1114970006117 motif 1; other site 1114970006118 motif 3; other site 1114970006119 motif 2; other site 1114970006120 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 1114970006121 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114970006122 IHF - DNA interface [nucleotide binding]; other site 1114970006123 IHF dimer interface [polypeptide binding]; other site 1114970006124 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1114970006125 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114970006126 DNA binding residues [nucleotide binding] 1114970006127 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1114970006128 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1114970006129 putative ligand binding site [chemical binding]; other site 1114970006130 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1114970006131 short chain dehydrogenase; Provisional; Region: PRK06198 1114970006132 classical (c) SDRs; Region: SDR_c; cd05233 1114970006133 NAD(P) binding site [chemical binding]; other site 1114970006134 active site 1114970006135 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970006136 DNA binding site [nucleotide binding] 1114970006137 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1114970006138 putative ligand binding site [chemical binding]; other site 1114970006139 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1114970006140 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1114970006141 active site 1114970006142 dimer interface [polypeptide binding]; other site 1114970006143 metal binding site [ion binding]; metal-binding site 1114970006144 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970006145 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1114970006146 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 1114970006147 active site 1114970006148 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970006149 Helix-turn-helix domains; Region: HTH; cl00088 1114970006150 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970006151 putative effector binding pocket; other site 1114970006152 dimerization interface [polypeptide binding]; other site 1114970006153 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1114970006154 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1114970006155 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114970006156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970006157 putative substrate translocation pore; other site 1114970006158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970006159 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 1114970006160 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1114970006161 dimer interface [polypeptide binding]; other site 1114970006162 active site 1114970006163 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1114970006164 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114970006165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006166 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1114970006167 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114970006168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006169 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1114970006170 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1114970006171 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1114970006172 putative ligand binding site [chemical binding]; other site 1114970006173 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1114970006174 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 1114970006175 Walker A/P-loop; other site 1114970006176 ATP binding site [chemical binding]; other site 1114970006177 Q-loop/lid; other site 1114970006178 ABC transporter signature motif; other site 1114970006179 Walker B; other site 1114970006180 D-loop; other site 1114970006181 H-loop/switch region; other site 1114970006182 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1114970006183 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1114970006184 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114970006185 TM-ABC transporter signature motif; other site 1114970006186 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 1114970006187 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1114970006188 active site 1114970006189 DNA binding site [nucleotide binding] 1114970006190 Int/Topo IB signature motif; other site 1114970006191 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970006192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970006193 active site 1114970006194 phosphorylation site [posttranslational modification] 1114970006195 intermolecular recognition site; other site 1114970006196 dimerization interface [polypeptide binding]; other site 1114970006197 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970006198 DNA binding residues [nucleotide binding] 1114970006199 dimerization interface [polypeptide binding]; other site 1114970006200 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114970006201 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114970006202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970006203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970006204 dimer interface [polypeptide binding]; other site 1114970006205 phosphorylation site [posttranslational modification] 1114970006206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970006207 ATP binding site [chemical binding]; other site 1114970006208 Mg2+ binding site [ion binding]; other site 1114970006209 G-X-G motif; other site 1114970006210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970006211 active site 1114970006212 phosphorylation site [posttranslational modification] 1114970006213 intermolecular recognition site; other site 1114970006214 dimerization interface [polypeptide binding]; other site 1114970006215 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1114970006216 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1114970006217 putative ligand binding site [chemical binding]; other site 1114970006218 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1114970006219 TM-ABC transporter signature motif; other site 1114970006220 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1114970006221 TM-ABC transporter signature motif; other site 1114970006222 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1114970006223 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 1114970006224 Walker A/P-loop; other site 1114970006225 ATP binding site [chemical binding]; other site 1114970006226 Q-loop/lid; other site 1114970006227 ABC transporter signature motif; other site 1114970006228 Walker B; other site 1114970006229 D-loop; other site 1114970006230 H-loop/switch region; other site 1114970006231 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1114970006232 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 1114970006233 Walker A/P-loop; other site 1114970006234 ATP binding site [chemical binding]; other site 1114970006235 Q-loop/lid; other site 1114970006236 ABC transporter signature motif; other site 1114970006237 Walker B; other site 1114970006238 D-loop; other site 1114970006239 H-loop/switch region; other site 1114970006240 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 1114970006241 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 1114970006242 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114970006243 multimer interface [polypeptide binding]; other site 1114970006244 active site 1114970006245 catalytic triad [active] 1114970006246 dimer interface [polypeptide binding]; other site 1114970006247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970006248 Walker A motif; other site 1114970006249 ATP binding site [chemical binding]; other site 1114970006250 Walker B motif; other site 1114970006251 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1114970006252 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970006253 dimerization interface [polypeptide binding]; other site 1114970006254 putative DNA binding site [nucleotide binding]; other site 1114970006255 putative Zn2+ binding site [ion binding]; other site 1114970006256 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1114970006257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006258 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1114970006259 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970006260 dimerization interface [polypeptide binding]; other site 1114970006261 putative DNA binding site [nucleotide binding]; other site 1114970006262 putative Zn2+ binding site [ion binding]; other site 1114970006263 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970006264 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 1114970006265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006266 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1114970006267 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970006268 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114970006269 Predicted permease; Region: DUF318; pfam03773 1114970006270 Predicted permease; Region: DUF318; pfam03773 1114970006271 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114970006272 DKNYY family; Region: DKNYY; pfam13644 1114970006273 DKNYY family; Region: DKNYY; pfam13644 1114970006274 DKNYY family; Region: DKNYY; pfam13644 1114970006275 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 1114970006276 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1114970006277 putative homodimer interface [polypeptide binding]; other site 1114970006278 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1114970006279 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1114970006280 active site 1114970006281 homodimer interface [polypeptide binding]; other site 1114970006282 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1114970006283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006284 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970006285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006286 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1114970006287 NAD(P) binding site [chemical binding]; other site 1114970006288 active site 1114970006289 GtrA-like protein; Region: GtrA; cl00971 1114970006290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970006291 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1114970006292 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1114970006293 Ligand binding site; other site 1114970006294 Putative Catalytic site; other site 1114970006295 DXD motif; other site 1114970006296 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1114970006297 putative homodimer interface [polypeptide binding]; other site 1114970006298 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114970006299 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1114970006300 Probable Catalytic site; other site 1114970006301 metal-binding site 1114970006302 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114970006303 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1114970006304 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 1114970006305 Walker A/P-loop; other site 1114970006306 ATP binding site [chemical binding]; other site 1114970006307 Q-loop/lid; other site 1114970006308 ABC transporter signature motif; other site 1114970006309 Walker B; other site 1114970006310 D-loop; other site 1114970006311 H-loop/switch region; other site 1114970006312 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1114970006313 putative carbohydrate binding site [chemical binding]; other site 1114970006314 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1114970006315 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1114970006316 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1114970006317 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1114970006318 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970006319 putative homodimer interface [polypeptide binding]; other site 1114970006320 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114970006321 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1114970006322 Probable Catalytic site; other site 1114970006323 metal-binding site 1114970006324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006325 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1114970006326 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970006327 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970006328 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1114970006329 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970006330 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970006331 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970006332 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970006333 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970006334 Surface antigen; Region: Bac_surface_Ag; cl03097 1114970006335 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1114970006336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970006337 active site 1114970006338 phosphorylation site [posttranslational modification] 1114970006339 intermolecular recognition site; other site 1114970006340 dimerization interface [polypeptide binding]; other site 1114970006341 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970006342 DNA binding site [nucleotide binding] 1114970006343 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970006344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970006345 dimer interface [polypeptide binding]; other site 1114970006346 phosphorylation site [posttranslational modification] 1114970006347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970006348 ATP binding site [chemical binding]; other site 1114970006349 Mg2+ binding site [ion binding]; other site 1114970006350 G-X-G motif; other site 1114970006351 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1114970006352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970006353 active site 1114970006354 phosphorylation site [posttranslational modification] 1114970006355 intermolecular recognition site; other site 1114970006356 dimerization interface [polypeptide binding]; other site 1114970006357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970006358 DNA binding site [nucleotide binding] 1114970006359 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1114970006360 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970006361 dimerization interface [polypeptide binding]; other site 1114970006362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970006363 dimer interface [polypeptide binding]; other site 1114970006364 phosphorylation site [posttranslational modification] 1114970006365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970006366 ATP binding site [chemical binding]; other site 1114970006367 Mg2+ binding site [ion binding]; other site 1114970006368 G-X-G motif; other site 1114970006369 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1114970006370 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970006371 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970006372 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1114970006373 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970006374 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1114970006375 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1114970006376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970006377 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1114970006378 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970006379 NAD(P) binding site [chemical binding]; other site 1114970006380 catalytic residues [active] 1114970006381 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1114970006382 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 1114970006383 active site 1114970006384 metal binding site [ion binding]; metal-binding site 1114970006385 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1114970006386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006387 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970006388 Helix-turn-helix domains; Region: HTH; cl00088 1114970006389 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970006390 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1114970006391 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970006392 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970006393 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1114970006394 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 1114970006395 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1114970006396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970006397 Helix-turn-helix domains; Region: HTH; cl00088 1114970006398 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114970006399 CoenzymeA binding site [chemical binding]; other site 1114970006400 subunit interaction site [polypeptide binding]; other site 1114970006401 PHB binding site; other site 1114970006402 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1114970006403 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1114970006404 FAD binding pocket [chemical binding]; other site 1114970006405 FAD binding motif [chemical binding]; other site 1114970006406 phosphate binding motif [ion binding]; other site 1114970006407 beta-alpha-beta structure motif; other site 1114970006408 NAD binding pocket [chemical binding]; other site 1114970006409 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970006410 catalytic loop [active] 1114970006411 iron binding site [ion binding]; other site 1114970006412 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1114970006413 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1114970006414 [2Fe-2S] cluster binding site [ion binding]; other site 1114970006415 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1114970006416 putative alpha subunit interface [polypeptide binding]; other site 1114970006417 putative active site [active] 1114970006418 putative substrate binding site [chemical binding]; other site 1114970006419 Fe binding site [ion binding]; other site 1114970006420 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1114970006421 Helix-turn-helix domains; Region: HTH; cl00088 1114970006422 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970006423 dimerization interface [polypeptide binding]; other site 1114970006424 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1114970006425 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970006426 Walker A/P-loop; other site 1114970006427 ATP binding site [chemical binding]; other site 1114970006428 Q-loop/lid; other site 1114970006429 ABC transporter signature motif; other site 1114970006430 Walker B; other site 1114970006431 D-loop; other site 1114970006432 H-loop/switch region; other site 1114970006433 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1114970006434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970006435 dimer interface [polypeptide binding]; other site 1114970006436 conserved gate region; other site 1114970006437 putative PBP binding loops; other site 1114970006438 ABC-ATPase subunit interface; other site 1114970006439 Helix-turn-helix domains; Region: HTH; cl00088 1114970006440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006441 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1114970006442 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1114970006443 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970006444 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1114970006445 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1114970006446 substrate binding site [chemical binding]; other site 1114970006447 catalytic Zn binding site [ion binding]; other site 1114970006448 NAD binding site [chemical binding]; other site 1114970006449 structural Zn binding site [ion binding]; other site 1114970006450 dimer interface [polypeptide binding]; other site 1114970006451 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1114970006452 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1114970006453 putative active site [active] 1114970006454 putative FMN binding site [chemical binding]; other site 1114970006455 putative substrate binding site [chemical binding]; other site 1114970006456 putative catalytic residue [active] 1114970006457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006458 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1114970006459 Ligand binding site [chemical binding]; other site 1114970006460 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1114970006461 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1114970006462 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1114970006463 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1114970006464 NMT1-like family; Region: NMT1_2; cl15260 1114970006465 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114970006466 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1114970006467 Cache domain; Region: Cache_1; pfam02743 1114970006468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970006469 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970006470 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970006471 dimer interface [polypeptide binding]; other site 1114970006472 putative CheW interface [polypeptide binding]; other site 1114970006473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970006474 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1114970006475 DNA-binding site [nucleotide binding]; DNA binding site 1114970006476 FCD domain; Region: FCD; cl11656 1114970006477 NMT1-like family; Region: NMT1_2; cl15260 1114970006478 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114970006479 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 1114970006480 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970006481 Walker A/P-loop; other site 1114970006482 ATP binding site [chemical binding]; other site 1114970006483 Q-loop/lid; other site 1114970006484 ABC transporter signature motif; other site 1114970006485 Walker B; other site 1114970006486 D-loop; other site 1114970006487 H-loop/switch region; other site 1114970006488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970006489 dimer interface [polypeptide binding]; other site 1114970006490 conserved gate region; other site 1114970006491 putative PBP binding loops; other site 1114970006492 ABC-ATPase subunit interface; other site 1114970006493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970006494 dimer interface [polypeptide binding]; other site 1114970006495 conserved gate region; other site 1114970006496 ABC-ATPase subunit interface; other site 1114970006497 Possible frameshift of a hydroxyproline-2-epimerase 1114970006498 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970006499 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1114970006500 conserved cys residue [active] 1114970006501 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970006502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970006503 DNA-binding site [nucleotide binding]; DNA binding site 1114970006504 FCD domain; Region: FCD; cl11656 1114970006505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006506 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970006507 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1114970006508 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1114970006509 inhibitor site; inhibition site 1114970006510 active site 1114970006511 dimer interface [polypeptide binding]; other site 1114970006512 catalytic residue [active] 1114970006513 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970006514 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1114970006515 NAD(P) binding site [chemical binding]; other site 1114970006516 catalytic residues [active] 1114970006517 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970006518 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1114970006519 conserved cys residue [active] 1114970006520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970006521 Pirin-related protein [General function prediction only]; Region: COG1741 1114970006522 Cupin domain; Region: Cupin_2; cl09118 1114970006523 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1114970006524 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970006525 conserved cys residue [active] 1114970006526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970006527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970006528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970006529 DNA binding site [nucleotide binding] 1114970006530 Predicted ATPase [General function prediction only]; Region: COG3903 1114970006531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970006532 DNA binding site [nucleotide binding] 1114970006533 Predicted ATPase [General function prediction only]; Region: COG3903 1114970006534 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970006535 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970006536 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970006537 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970006538 Helix-turn-helix domains; Region: HTH; cl00088 1114970006539 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1114970006540 putative substrate binding pocket [chemical binding]; other site 1114970006541 putative dimerization interface [polypeptide binding]; other site 1114970006542 DoxX; Region: DoxX; cl00976 1114970006543 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114970006544 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1114970006545 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1114970006546 active site 1114970006547 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970006548 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1114970006549 catalytic triad [active] 1114970006550 dimer interface [polypeptide binding]; other site 1114970006551 conserved cis-peptide bond; other site 1114970006552 Helix-turn-helix domains; Region: HTH; cl00088 1114970006553 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970006554 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970006555 putative effector binding pocket; other site 1114970006556 dimerization interface [polypeptide binding]; other site 1114970006557 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 1114970006558 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1114970006559 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 1114970006560 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 1114970006561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970006562 Coenzyme A binding pocket [chemical binding]; other site 1114970006563 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1114970006564 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1114970006565 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1114970006566 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1114970006567 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1114970006568 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1114970006569 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1114970006570 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1114970006571 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1114970006572 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1114970006573 4Fe-4S binding domain; Region: Fer4; cl02805 1114970006574 4Fe-4S binding domain; Region: Fer4; cl02805 1114970006575 NADH dehydrogenase; Region: NADHdh; cl00469 1114970006576 NADH dehydrogenase subunit G; Validated; Region: PRK08166 1114970006577 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970006578 catalytic loop [active] 1114970006579 iron binding site [ion binding]; other site 1114970006580 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 1114970006581 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1114970006582 [4Fe-4S] binding site [ion binding]; other site 1114970006583 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1114970006584 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1114970006585 SLBB domain; Region: SLBB; pfam10531 1114970006586 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 1114970006587 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 1114970006588 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1114970006589 putative dimer interface [polypeptide binding]; other site 1114970006590 [2Fe-2S] cluster binding site [ion binding]; other site 1114970006591 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1114970006592 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1114970006593 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 1114970006594 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1114970006595 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 1114970006596 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1114970006597 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1114970006598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970006599 dimerization interface [polypeptide binding]; other site 1114970006600 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970006601 dimer interface [polypeptide binding]; other site 1114970006602 putative CheW interface [polypeptide binding]; other site 1114970006603 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1114970006604 tetramer interface [polypeptide binding]; other site 1114970006605 active site 1114970006606 Mg2+/Mn2+ binding site [ion binding]; other site 1114970006607 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970006608 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970006609 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1114970006610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970006611 Coenzyme A binding pocket [chemical binding]; other site 1114970006612 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1114970006613 Cupin domain; Region: Cupin_2; cl09118 1114970006614 adenylosuccinate lyase; Provisional; Region: PRK09285 1114970006615 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1114970006616 tetramer interface [polypeptide binding]; other site 1114970006617 active site 1114970006618 Protein of unknown function (DUF489); Region: DUF489; cl01097 1114970006619 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1114970006620 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1114970006621 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1114970006622 nudix motif; other site 1114970006623 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1114970006624 isocitrate dehydrogenase; Validated; Region: PRK07362 1114970006625 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114970006626 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1114970006627 DNA-binding site [nucleotide binding]; DNA binding site 1114970006628 RNA-binding motif; other site 1114970006629 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1114970006630 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1114970006631 Clp amino terminal domain; Region: Clp_N; pfam02861 1114970006632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970006633 Walker A motif; other site 1114970006634 ATP binding site [chemical binding]; other site 1114970006635 Walker B motif; other site 1114970006636 arginine finger; other site 1114970006637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970006638 Walker A motif; other site 1114970006639 ATP binding site [chemical binding]; other site 1114970006640 Walker B motif; other site 1114970006641 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1114970006642 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1114970006643 rRNA binding site [nucleotide binding]; other site 1114970006644 predicted 30S ribosome binding site; other site 1114970006645 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1114970006646 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1114970006647 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970006648 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970006649 thioredoxin reductase; Provisional; Region: PRK10262 1114970006650 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970006651 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1114970006652 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1114970006653 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970006654 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 1114970006655 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 1114970006656 recombination factor protein RarA; Reviewed; Region: PRK13342 1114970006657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970006658 Walker A motif; other site 1114970006659 ATP binding site [chemical binding]; other site 1114970006660 Walker B motif; other site 1114970006661 arginine finger; other site 1114970006662 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1114970006663 CrcB-like protein; Region: CRCB; cl09114 1114970006664 seryl-tRNA synthetase; Provisional; Region: PRK05431 1114970006665 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1114970006666 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 1114970006667 dimer interface [polypeptide binding]; other site 1114970006668 active site 1114970006669 motif 1; other site 1114970006670 motif 2; other site 1114970006671 motif 3; other site 1114970006672 siroheme synthase; Provisional; Region: cysG; PRK10637 1114970006673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006674 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1114970006675 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1114970006676 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1114970006677 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114970006678 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1114970006679 putative dimer interface [polypeptide binding]; other site 1114970006680 N-terminal domain interface [polypeptide binding]; other site 1114970006681 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970006682 hypothetical protein; Validated; Region: PRK09071 1114970006683 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1114970006684 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1114970006685 DsrC like protein; Region: DsrC; cl01101 1114970006686 DsrE/DsrF-like family; Region: DrsE; cl00672 1114970006687 DsrE/DsrF-like family; Region: DrsE; cl00672 1114970006688 DsrE/DsrF-like family; Region: DrsE; cl00672 1114970006689 DNA helicase IV; Provisional; Region: helD; PRK11054 1114970006690 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970006691 DNA helicase IV; Provisional; Region: helD; PRK11054 1114970006692 Family description; Region: UvrD_C_2; cl15862 1114970006693 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1114970006694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970006695 Coenzyme A binding pocket [chemical binding]; other site 1114970006696 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1114970006697 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1114970006698 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1114970006699 catalytic triad [active] 1114970006700 conserved cis-peptide bond; other site 1114970006701 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1114970006702 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1114970006703 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1114970006704 EamA-like transporter family; Region: EamA; cl01037 1114970006705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970006706 dimer interface [polypeptide binding]; other site 1114970006707 phosphorylation site [posttranslational modification] 1114970006708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970006709 ATP binding site [chemical binding]; other site 1114970006710 Mg2+ binding site [ion binding]; other site 1114970006711 G-X-G motif; other site 1114970006712 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1114970006713 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 1114970006714 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1114970006715 DctM-like transporters; Region: DctM; pfam06808 1114970006716 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1114970006717 NMT1-like family; Region: NMT1_2; cl15260 1114970006718 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970006719 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970006720 DNA binding site [nucleotide binding] 1114970006721 domain linker motif; other site 1114970006722 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1114970006723 dimerization interface [polypeptide binding]; other site 1114970006724 ligand binding site [chemical binding]; other site 1114970006725 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114970006726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006727 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1114970006728 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114970006729 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114970006730 Metal-binding active site; metal-binding site 1114970006731 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1114970006732 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 1114970006733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970006734 Alginate lyase; Region: Alginate_lyase2; pfam08787 1114970006735 glycolate transporter; Provisional; Region: PRK09695 1114970006736 L-lactate permease; Region: Lactate_perm; cl00701 1114970006737 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114970006738 homotrimer interaction site [polypeptide binding]; other site 1114970006739 putative active site [active] 1114970006740 Possible Frameshift 1114970006741 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970006742 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1114970006743 active site 1114970006744 catalytic tetrad [active] 1114970006745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970006746 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970006747 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1114970006748 conserved cys residue [active] 1114970006749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970006750 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1114970006751 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1114970006752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006753 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970006754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970006755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970006756 dimer interface [polypeptide binding]; other site 1114970006757 phosphorylation site [posttranslational modification] 1114970006758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970006759 ATP binding site [chemical binding]; other site 1114970006760 Mg2+ binding site [ion binding]; other site 1114970006761 G-X-G motif; other site 1114970006762 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1114970006763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970006764 active site 1114970006765 phosphorylation site [posttranslational modification] 1114970006766 intermolecular recognition site; other site 1114970006767 dimerization interface [polypeptide binding]; other site 1114970006768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970006769 DNA binding site [nucleotide binding] 1114970006770 VacJ like lipoprotein; Region: VacJ; cl01073 1114970006771 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1114970006772 dimer interface [polypeptide binding]; other site 1114970006773 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1114970006774 homotrimer interaction site [polypeptide binding]; other site 1114970006775 putative active site [active] 1114970006776 transcriptional regulator; Provisional; Region: PRK10632 1114970006777 Helix-turn-helix domains; Region: HTH; cl00088 1114970006778 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1114970006779 putative effector binding pocket; other site 1114970006780 putative dimerization interface [polypeptide binding]; other site 1114970006781 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1114970006782 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1114970006783 NAD binding site [chemical binding]; other site 1114970006784 catalytic residues [active] 1114970006785 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970006786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006787 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114970006788 homotrimer interaction site [polypeptide binding]; other site 1114970006789 putative active site [active] 1114970006790 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 1114970006791 active site 1114970006792 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970006793 dimer interface [polypeptide binding]; other site 1114970006794 substrate binding site [chemical binding]; other site 1114970006795 catalytic residue [active] 1114970006796 Helix-turn-helix domains; Region: HTH; cl00088 1114970006797 transcriptional activator TtdR; Provisional; Region: PRK09801 1114970006798 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970006799 dimerization interface [polypeptide binding]; other site 1114970006800 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1114970006801 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114970006802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006803 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970006804 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1114970006805 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1114970006806 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114970006807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970006808 dimer interface [polypeptide binding]; other site 1114970006809 conserved gate region; other site 1114970006810 putative PBP binding loops; other site 1114970006811 ABC-ATPase subunit interface; other site 1114970006812 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114970006813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970006814 dimer interface [polypeptide binding]; other site 1114970006815 conserved gate region; other site 1114970006816 ABC-ATPase subunit interface; other site 1114970006817 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1114970006818 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114970006819 Walker A/P-loop; other site 1114970006820 ATP binding site [chemical binding]; other site 1114970006821 Q-loop/lid; other site 1114970006822 ABC transporter signature motif; other site 1114970006823 Walker B; other site 1114970006824 D-loop; other site 1114970006825 H-loop/switch region; other site 1114970006826 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114970006827 Walker A/P-loop; other site 1114970006828 ATP binding site [chemical binding]; other site 1114970006829 Q-loop/lid; other site 1114970006830 ABC transporter signature motif; other site 1114970006831 Walker B; other site 1114970006832 D-loop; other site 1114970006833 H-loop/switch region; other site 1114970006834 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970006835 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1114970006836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1114970006837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006838 putative oxidoreductase; Provisional; Region: PRK08275 1114970006839 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1114970006840 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970006841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006843 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1114970006844 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 1114970006845 metal binding site [ion binding]; metal-binding site 1114970006846 putative dimer interface [polypeptide binding]; other site 1114970006847 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970006848 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1114970006849 tetramerization interface [polypeptide binding]; other site 1114970006850 NAD(P) binding site [chemical binding]; other site 1114970006851 catalytic residues [active] 1114970006852 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114970006853 tartrate dehydrogenase; Provisional; Region: PRK08194 1114970006854 Cupin domain; Region: Cupin_2; cl09118 1114970006855 Cupin domain; Region: Cupin_2; cl09118 1114970006856 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114970006857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970006858 Coenzyme A binding pocket [chemical binding]; other site 1114970006859 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1114970006860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006861 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1114970006862 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970006863 inhibitor-cofactor binding pocket; inhibition site 1114970006864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970006865 catalytic residue [active] 1114970006866 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970006867 Helix-turn-helix domains; Region: HTH; cl00088 1114970006868 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970006869 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970006870 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970006871 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970006872 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970006873 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970006874 substrate binding pocket [chemical binding]; other site 1114970006875 membrane-bound complex binding site; other site 1114970006876 hinge residues; other site 1114970006877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970006878 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1114970006879 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1114970006880 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970006881 N-terminal plug; other site 1114970006882 ligand-binding site [chemical binding]; other site 1114970006883 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1114970006884 Helix-turn-helix domains; Region: HTH; cl00088 1114970006885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970006886 dimerization interface [polypeptide binding]; other site 1114970006887 AzlC protein; Region: AzlC; cl00570 1114970006888 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970006889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970006890 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970006891 putative substrate translocation pore; other site 1114970006892 transcriptional regulator; Provisional; Region: PRK10632 1114970006893 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970006894 dimerization interface [polypeptide binding]; other site 1114970006895 pteridine reductase; Provisional; Region: PRK09135 1114970006896 classical (c) SDRs; Region: SDR_c; cd05233 1114970006897 NAD(P) binding site [chemical binding]; other site 1114970006898 active site 1114970006899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970006900 Coenzyme A binding pocket [chemical binding]; other site 1114970006901 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970006902 Helix-turn-helix domains; Region: HTH; cl00088 1114970006903 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970006904 dimerization interface [polypeptide binding]; other site 1114970006905 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970006906 Helix-turn-helix domains; Region: HTH; cl00088 1114970006907 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970006908 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970006909 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970006910 Integrase core domain; Region: rve; cl01316 1114970006911 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970006912 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1114970006913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1114970006914 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1114970006915 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970006916 Helix-turn-helix domains; Region: HTH; cl00088 1114970006917 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970006918 dimerization interface [polypeptide binding]; other site 1114970006919 EamA-like transporter family; Region: EamA; cl01037 1114970006920 EamA-like transporter family; Region: EamA; cl01037 1114970006921 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1114970006922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970006923 active site 1114970006924 phosphorylation site [posttranslational modification] 1114970006925 intermolecular recognition site; other site 1114970006926 dimerization interface [polypeptide binding]; other site 1114970006927 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970006928 DNA binding residues [nucleotide binding] 1114970006929 dimerization interface [polypeptide binding]; other site 1114970006930 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970006931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114970006932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970006933 ATP binding site [chemical binding]; other site 1114970006934 Mg2+ binding site [ion binding]; other site 1114970006935 G-X-G motif; other site 1114970006936 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1114970006937 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1114970006938 Walker A/P-loop; other site 1114970006939 ATP binding site [chemical binding]; other site 1114970006940 Q-loop/lid; other site 1114970006941 ABC transporter signature motif; other site 1114970006942 Walker B; other site 1114970006943 D-loop; other site 1114970006944 H-loop/switch region; other site 1114970006945 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 1114970006946 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1114970006947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970006948 dimer interface [polypeptide binding]; other site 1114970006949 conserved gate region; other site 1114970006950 putative PBP binding loops; other site 1114970006951 ABC-ATPase subunit interface; other site 1114970006952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970006953 dimer interface [polypeptide binding]; other site 1114970006954 conserved gate region; other site 1114970006955 putative PBP binding loops; other site 1114970006956 ABC-ATPase subunit interface; other site 1114970006957 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1114970006958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970006959 active site 1114970006960 phosphorylation site [posttranslational modification] 1114970006961 intermolecular recognition site; other site 1114970006962 dimerization interface [polypeptide binding]; other site 1114970006963 CheB methylesterase; Region: CheB_methylest; pfam01339 1114970006964 CheD chemotactic sensory transduction; Region: CheD; cl00810 1114970006965 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1114970006966 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1114970006967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970006968 S-adenosylmethionine binding site [chemical binding]; other site 1114970006969 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1114970006970 putative CheA interaction surface; other site 1114970006971 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970006972 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970006973 dimerization interface [polypeptide binding]; other site 1114970006974 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970006975 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970006976 dimer interface [polypeptide binding]; other site 1114970006977 putative CheW interface [polypeptide binding]; other site 1114970006978 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1114970006979 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970006980 putative binding surface; other site 1114970006981 active site 1114970006982 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1114970006983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970006984 ATP binding site [chemical binding]; other site 1114970006985 Mg2+ binding site [ion binding]; other site 1114970006986 G-X-G motif; other site 1114970006987 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1114970006988 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1114970006989 anti sigma factor interaction site; other site 1114970006990 regulatory phosphorylation site [posttranslational modification]; other site 1114970006991 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970006992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970006993 active site 1114970006994 phosphorylation site [posttranslational modification] 1114970006995 intermolecular recognition site; other site 1114970006996 dimerization interface [polypeptide binding]; other site 1114970006997 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1114970006998 MatE; Region: MatE; cl10513 1114970006999 MatE; Region: MatE; cl10513 1114970007000 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114970007001 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1114970007002 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1114970007003 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1114970007004 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 1114970007005 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1114970007006 active site 1114970007007 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1114970007008 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 1114970007009 active site 1114970007010 DNA binding site [nucleotide binding] 1114970007011 Int/Topo IB signature motif; other site 1114970007012 catalytic residues [active] 1114970007013 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970007014 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 1114970007015 Walker A/P-loop; other site 1114970007016 ATP binding site [chemical binding]; other site 1114970007017 Q-loop/lid; other site 1114970007018 ABC transporter signature motif; other site 1114970007019 Walker B; other site 1114970007020 D-loop; other site 1114970007021 H-loop/switch region; other site 1114970007022 TOBE domain; Region: TOBE_2; cl01440 1114970007023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970007024 dimer interface [polypeptide binding]; other site 1114970007025 conserved gate region; other site 1114970007026 putative PBP binding loops; other site 1114970007027 ABC-ATPase subunit interface; other site 1114970007028 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1114970007029 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970007030 Nitronate monooxygenase; Region: NMO; pfam03060 1114970007031 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1114970007032 FMN binding site [chemical binding]; other site 1114970007033 substrate binding site [chemical binding]; other site 1114970007034 putative catalytic residue [active] 1114970007035 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1114970007036 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1114970007037 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1114970007038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970007039 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1114970007040 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114970007041 DNA binding site [nucleotide binding] 1114970007042 active site 1114970007043 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1114970007044 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1114970007045 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cl02586 1114970007046 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1114970007047 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1114970007048 active site 1114970007049 tetramer interface; other site 1114970007050 glutathione reductase; Validated; Region: PRK06116 1114970007051 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970007052 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114970007053 peroxiredoxin; Region: AhpC; TIGR03137 1114970007054 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1114970007055 dimer interface [polypeptide binding]; other site 1114970007056 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1114970007057 catalytic triad [active] 1114970007058 peroxidatic and resolving cysteines [active] 1114970007059 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1114970007060 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1114970007061 catalytic residue [active] 1114970007062 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1114970007063 catalytic residues [active] 1114970007064 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970007065 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1114970007066 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970007067 dimer interface [polypeptide binding]; other site 1114970007068 active site 1114970007069 metal binding site [ion binding]; metal-binding site 1114970007070 glutathione binding site [chemical binding]; other site 1114970007071 phage resistance protein; Provisional; Region: PRK10551 1114970007072 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1114970007073 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970007074 Helix-turn-helix domains; Region: HTH; cl00088 1114970007075 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1114970007076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970007077 dimerization interface [polypeptide binding]; other site 1114970007078 EamA-like transporter family; Region: EamA; cl01037 1114970007079 EamA-like transporter family; Region: EamA; cl01037 1114970007080 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1114970007081 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1114970007082 dimer interface [polypeptide binding]; other site 1114970007083 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1114970007084 active site 1114970007085 Fe binding site [ion binding]; other site 1114970007086 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1114970007087 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1114970007088 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970007089 active site 1114970007090 catalytic tetrad [active] 1114970007091 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1114970007092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007093 putative substrate translocation pore; other site 1114970007094 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1114970007095 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1114970007096 Helix-turn-helix domains; Region: HTH; cl00088 1114970007097 Glycerate kinase family; Region: Gly_kinase; cl00841 1114970007098 aspartate aminotransferase; Provisional; Region: PRK05764 1114970007099 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970007100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970007101 homodimer interface [polypeptide binding]; other site 1114970007102 catalytic residue [active] 1114970007103 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970007104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970007105 active site 1114970007106 phosphorylation site [posttranslational modification] 1114970007107 intermolecular recognition site; other site 1114970007108 dimerization interface [polypeptide binding]; other site 1114970007109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970007110 DNA binding site [nucleotide binding] 1114970007111 sensor protein RstB; Provisional; Region: PRK10604 1114970007112 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970007113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114970007114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970007115 ATP binding site [chemical binding]; other site 1114970007116 Mg2+ binding site [ion binding]; other site 1114970007117 G-X-G motif; other site 1114970007118 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 1114970007119 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1114970007120 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970007121 catalytic triad [active] 1114970007122 metal binding site [ion binding]; metal-binding site 1114970007123 conserved cis-peptide bond; other site 1114970007124 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1114970007125 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1114970007126 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1114970007127 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970007128 metal binding site [ion binding]; metal-binding site 1114970007129 active site 1114970007130 I-site; other site 1114970007131 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970007132 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1114970007133 A new structural DNA glycosylase; Region: AlkD_like; cl11434 1114970007134 active site 1114970007135 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1114970007136 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1114970007137 active site 1114970007138 Zn binding site [ion binding]; other site 1114970007139 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1114970007140 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970007141 dimerization interface [polypeptide binding]; other site 1114970007142 putative DNA binding site [nucleotide binding]; other site 1114970007143 putative Zn2+ binding site [ion binding]; other site 1114970007144 Cupin domain; Region: Cupin_2; cl09118 1114970007145 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970007146 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970007147 EamA-like transporter family; Region: EamA; cl01037 1114970007148 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1114970007149 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1114970007150 homodimer interface [polypeptide binding]; other site 1114970007151 substrate-cofactor binding pocket; other site 1114970007152 catalytic residue [active] 1114970007153 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1114970007154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970007155 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114970007156 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1114970007157 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114970007158 E3 interaction surface; other site 1114970007159 lipoyl attachment site [posttranslational modification]; other site 1114970007160 e3 binding domain; Region: E3_binding; pfam02817 1114970007161 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1114970007162 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1114970007163 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1114970007164 alpha subunit interface [polypeptide binding]; other site 1114970007165 TPP binding site [chemical binding]; other site 1114970007166 heterodimer interface [polypeptide binding]; other site 1114970007167 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114970007168 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 1114970007169 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1114970007170 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1114970007171 tetramer interface [polypeptide binding]; other site 1114970007172 TPP-binding site [chemical binding]; other site 1114970007173 heterodimer interface [polypeptide binding]; other site 1114970007174 phosphorylation loop region [posttranslational modification] 1114970007175 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970007176 Helix-turn-helix domains; Region: HTH; cl00088 1114970007177 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970007178 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 1114970007179 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1114970007180 active site 1114970007181 catalytic residues [active] 1114970007182 DctM-like transporters; Region: DctM; pfam06808 1114970007183 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1114970007184 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1114970007185 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1114970007186 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1114970007187 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1114970007188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007189 active site 1114970007190 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970007191 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1114970007192 Helix-turn-helix domains; Region: HTH; cl00088 1114970007193 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1114970007194 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970007195 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1114970007196 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1114970007197 homodimer interface [polypeptide binding]; other site 1114970007198 active site 1114970007199 FMN binding site [chemical binding]; other site 1114970007200 substrate binding site [chemical binding]; other site 1114970007201 4Fe-4S binding domain; Region: Fer4; cl02805 1114970007202 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1114970007203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007204 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970007205 phenylhydantoinase; Validated; Region: PRK08323 1114970007206 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1114970007207 tetramer interface [polypeptide binding]; other site 1114970007208 active site 1114970007209 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1114970007210 Na binding site [ion binding]; other site 1114970007211 putative substrate binding site [chemical binding]; other site 1114970007212 allantoate amidohydrolase; Reviewed; Region: PRK12893 1114970007213 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1114970007214 active site 1114970007215 metal binding site [ion binding]; metal-binding site 1114970007216 dimer interface [polypeptide binding]; other site 1114970007217 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970007218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970007219 putative active site [active] 1114970007220 heme pocket [chemical binding]; other site 1114970007221 PAS domain S-box; Region: sensory_box; TIGR00229 1114970007222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970007223 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970007224 DNA binding residues [nucleotide binding] 1114970007225 dimerization interface [polypeptide binding]; other site 1114970007226 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1114970007227 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1114970007228 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970007229 dimerization interface [polypeptide binding]; other site 1114970007230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970007231 dimer interface [polypeptide binding]; other site 1114970007232 phosphorylation site [posttranslational modification] 1114970007233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970007234 ATP binding site [chemical binding]; other site 1114970007235 Mg2+ binding site [ion binding]; other site 1114970007236 G-X-G motif; other site 1114970007237 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970007238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970007239 active site 1114970007240 phosphorylation site [posttranslational modification] 1114970007241 intermolecular recognition site; other site 1114970007242 dimerization interface [polypeptide binding]; other site 1114970007243 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970007244 DNA binding site [nucleotide binding] 1114970007245 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1114970007246 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1114970007247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007248 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1114970007249 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1114970007250 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970007251 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114970007252 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1114970007253 N-terminal domain interface [polypeptide binding]; other site 1114970007254 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970007255 dimer interface [polypeptide binding]; other site 1114970007256 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114970007257 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114970007258 putative active site [active] 1114970007259 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114970007260 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114970007261 substrate binding site [chemical binding]; other site 1114970007262 ATP binding site [chemical binding]; other site 1114970007263 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1114970007264 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114970007265 KduI/IolB family; Region: KduI; cl01508 1114970007266 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1114970007267 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970007268 tetrameric interface [polypeptide binding]; other site 1114970007269 NAD binding site [chemical binding]; other site 1114970007270 catalytic residues [active] 1114970007271 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1114970007272 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1114970007273 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114970007274 PYR/PP interface [polypeptide binding]; other site 1114970007275 dimer interface [polypeptide binding]; other site 1114970007276 TPP binding site [chemical binding]; other site 1114970007277 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1114970007278 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1114970007279 TPP-binding site; other site 1114970007280 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114970007281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007282 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1114970007283 putative oxidoreductase; Provisional; Region: PRK11579 1114970007284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007285 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1114970007286 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1114970007287 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1114970007288 putative ligand binding site [chemical binding]; other site 1114970007289 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1114970007290 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 1114970007291 Walker A/P-loop; other site 1114970007292 ATP binding site [chemical binding]; other site 1114970007293 Q-loop/lid; other site 1114970007294 ABC transporter signature motif; other site 1114970007295 Walker B; other site 1114970007296 D-loop; other site 1114970007297 H-loop/switch region; other site 1114970007298 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1114970007299 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1114970007300 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114970007301 TM-ABC transporter signature motif; other site 1114970007302 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1114970007303 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970007304 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970007305 dimer interface [polypeptide binding]; other site 1114970007306 putative CheW interface [polypeptide binding]; other site 1114970007307 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1114970007308 NMT1-like family; Region: NMT1_2; cl15260 1114970007309 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114970007310 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 1114970007311 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1114970007312 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1114970007313 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1114970007314 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1114970007315 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1114970007316 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1114970007317 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1114970007318 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1114970007319 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1114970007320 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1114970007321 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1114970007322 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1114970007323 Possible frameshift 1114970007324 EamA-like transporter family; Region: EamA; cl01037 1114970007325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970007326 non-specific DNA binding site [nucleotide binding]; other site 1114970007327 salt bridge; other site 1114970007328 sequence-specific DNA binding site [nucleotide binding]; other site 1114970007329 Cupin domain; Region: Cupin_2; cl09118 1114970007330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1114970007331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007332 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970007333 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970007334 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970007335 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970007336 type III secretion protein GogB; Provisional; Region: PRK15386 1114970007337 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1114970007338 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1114970007339 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 1114970007340 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114970007341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007342 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114970007343 classical (c) SDRs; Region: SDR_c; cd05233 1114970007344 NAD(P) binding site [chemical binding]; other site 1114970007345 active site 1114970007346 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 1114970007347 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1114970007348 putative active site [active] 1114970007349 putative substrate binding site [chemical binding]; other site 1114970007350 ATP binding site [chemical binding]; other site 1114970007351 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1114970007352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1114970007353 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1114970007354 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1114970007355 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970007356 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 1114970007357 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1114970007358 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1114970007359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970007360 Walker A motif; other site 1114970007361 ATP binding site [chemical binding]; other site 1114970007362 Walker B motif; other site 1114970007363 arginine finger; other site 1114970007364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970007365 Walker A motif; other site 1114970007366 ATP binding site [chemical binding]; other site 1114970007367 Walker B motif; other site 1114970007368 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 1114970007369 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1114970007370 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 1114970007371 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1114970007372 Protein of unknown function (DUF796); Region: DUF796; cl01226 1114970007373 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1114970007374 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1114970007375 Protein of unknown function (DUF770); Region: DUF770; cl01402 1114970007376 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1114970007377 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1114970007378 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1114970007379 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1114970007380 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1114970007381 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1114970007382 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1114970007383 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1114970007384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007385 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1114970007386 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 1114970007387 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1114970007388 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1114970007389 substrate binding site [chemical binding]; other site 1114970007390 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1114970007391 substrate binding site [chemical binding]; other site 1114970007392 ligand binding site [chemical binding]; other site 1114970007393 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 1114970007394 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1114970007395 universal stress protein UspE; Provisional; Region: PRK11175 1114970007396 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970007397 Ligand Binding Site [chemical binding]; other site 1114970007398 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1114970007399 active site 1114970007400 dinuclear metal binding site [ion binding]; other site 1114970007401 dimerization interface [polypeptide binding]; other site 1114970007402 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1114970007403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970007404 active site 1114970007405 phosphorylation site [posttranslational modification] 1114970007406 intermolecular recognition site; other site 1114970007407 dimerization interface [polypeptide binding]; other site 1114970007408 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970007409 DNA binding site [nucleotide binding] 1114970007410 sensor protein RstB; Provisional; Region: PRK10604 1114970007411 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970007412 dimerization interface [polypeptide binding]; other site 1114970007413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970007414 dimer interface [polypeptide binding]; other site 1114970007415 phosphorylation site [posttranslational modification] 1114970007416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970007417 ATP binding site [chemical binding]; other site 1114970007418 Mg2+ binding site [ion binding]; other site 1114970007419 G-X-G motif; other site 1114970007420 MltA-interacting protein MipA; Region: MipA; cl01504 1114970007421 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1114970007422 DNA-3-methyladenine glycosylase II frameshift 1114970007423 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1114970007424 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1114970007425 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1114970007426 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114970007427 DNA binding site [nucleotide binding] 1114970007428 active site 1114970007429 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1114970007430 Cation transport protein; Region: TrkH; cl10514 1114970007431 LysE type translocator; Region: LysE; cl00565 1114970007432 Cupin domain; Region: Cupin_2; cl09118 1114970007433 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970007434 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970007435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970007436 GAF domain; Region: GAF; cl15785 1114970007437 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970007438 metal binding site [ion binding]; metal-binding site 1114970007439 active site 1114970007440 I-site; other site 1114970007441 Possible frameshift 1114970007442 Nitrate and nitrite sensing; Region: NIT; pfam08376 1114970007443 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970007444 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970007445 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970007446 dimer interface [polypeptide binding]; other site 1114970007447 putative CheW interface [polypeptide binding]; other site 1114970007448 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970007449 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970007450 catalytic residue [active] 1114970007451 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1114970007452 putative phosphate binding site [ion binding]; other site 1114970007453 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114970007454 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114970007455 Walker A/P-loop; other site 1114970007456 ATP binding site [chemical binding]; other site 1114970007457 Q-loop/lid; other site 1114970007458 ABC transporter signature motif; other site 1114970007459 Walker B; other site 1114970007460 D-loop; other site 1114970007461 H-loop/switch region; other site 1114970007462 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114970007463 ABC-ATPase subunit interface; other site 1114970007464 dimer interface [polypeptide binding]; other site 1114970007465 putative PBP binding regions; other site 1114970007466 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1114970007467 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1114970007468 putative ligand binding residues [chemical binding]; other site 1114970007469 Secretin and TonB N terminus short domain; Region: STN; cl06624 1114970007470 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1114970007471 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970007472 N-terminal plug; other site 1114970007473 ligand-binding site [chemical binding]; other site 1114970007474 fec operon regulator FecR; Reviewed; Region: PRK09774 1114970007475 FecR protein; Region: FecR; pfam04773 1114970007476 RNA polymerase sigma factor; Provisional; Region: PRK12528 1114970007477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970007478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970007479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007480 putative substrate translocation pore; other site 1114970007481 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1114970007482 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970007483 N-terminal plug; other site 1114970007484 ligand-binding site [chemical binding]; other site 1114970007485 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970007486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007487 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970007488 putative substrate translocation pore; other site 1114970007489 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1114970007490 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1114970007491 malonyl-CoA binding site [chemical binding]; other site 1114970007492 dimer interface [polypeptide binding]; other site 1114970007493 active site 1114970007494 product binding site; other site 1114970007495 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1114970007496 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1114970007497 DUF35 OB-fold domain; Region: DUF35; pfam01796 1114970007498 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1114970007499 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1114970007500 active site 1114970007501 hypothetical protein; Provisional; Region: PRK04262 1114970007502 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 1114970007503 dimer interface [polypeptide binding]; other site 1114970007504 active site 1114970007505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970007506 Helix-turn-helix domains; Region: HTH; cl00088 1114970007507 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1114970007508 DoxX; Region: DoxX; cl00976 1114970007509 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1114970007510 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; cl04143 1114970007511 Dehydratase family; Region: ILVD_EDD; cl00340 1114970007512 putative dehydratase, YjhG/YagF family; Region: yjhG_yagF; TIGR03432 1114970007513 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 1114970007514 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970007515 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1114970007516 Helix-turn-helix domains; Region: HTH; cl00088 1114970007517 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1114970007518 putative dimerization interface [polypeptide binding]; other site 1114970007519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007520 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970007521 putative substrate translocation pore; other site 1114970007522 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970007523 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1114970007524 NAD binding site [chemical binding]; other site 1114970007525 homotetramer interface [polypeptide binding]; other site 1114970007526 homodimer interface [polypeptide binding]; other site 1114970007527 active site 1114970007528 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970007529 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970007530 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1114970007531 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970007532 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1114970007533 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970007534 Cache domain; Region: Cache_1; pfam02743 1114970007535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970007536 dimerization interface [polypeptide binding]; other site 1114970007537 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970007538 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970007539 dimer interface [polypeptide binding]; other site 1114970007540 putative CheW interface [polypeptide binding]; other site 1114970007541 Amino acid permease; Region: AA_permease; pfam00324 1114970007542 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970007543 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 1114970007544 NAD(P) binding site [chemical binding]; other site 1114970007545 catalytic residues [active] 1114970007546 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970007547 hypothetical protein; Provisional; Region: PRK07481 1114970007548 inhibitor-cofactor binding pocket; inhibition site 1114970007549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970007550 catalytic residue [active] 1114970007551 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1114970007552 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1114970007553 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970007554 Helix-turn-helix domains; Region: HTH; cl00088 1114970007555 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970007556 hypothetical protein; Validated; Region: PRK07586 1114970007557 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114970007558 PYR/PP interface [polypeptide binding]; other site 1114970007559 dimer interface [polypeptide binding]; other site 1114970007560 TPP binding site [chemical binding]; other site 1114970007561 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1114970007562 TPP-binding site [chemical binding]; other site 1114970007563 dimer interface [polypeptide binding]; other site 1114970007564 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114970007565 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970007566 NAD(P) binding site [chemical binding]; other site 1114970007567 catalytic residues [active] 1114970007568 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970007569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007570 NAD(P) binding site [chemical binding]; other site 1114970007571 active site 1114970007572 Ycf48-like protein; Provisional; Region: PRK13684 1114970007573 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1114970007574 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970007575 active site 1114970007576 metal binding site [ion binding]; metal-binding site 1114970007577 Amino acid synthesis; Region: AA_synth; pfam06684 1114970007578 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970007579 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970007580 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1114970007581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007583 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970007584 transcriptional regulator EutR; Provisional; Region: PRK10130 1114970007585 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970007586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970007587 DNA-binding site [nucleotide binding]; DNA binding site 1114970007588 FCD domain; Region: FCD; cl11656 1114970007589 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970007590 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970007591 substrate binding pocket [chemical binding]; other site 1114970007592 membrane-bound complex binding site; other site 1114970007593 hinge residues; other site 1114970007594 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970007595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970007596 dimer interface [polypeptide binding]; other site 1114970007597 conserved gate region; other site 1114970007598 putative PBP binding loops; other site 1114970007599 ABC-ATPase subunit interface; other site 1114970007600 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970007601 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970007602 Walker A/P-loop; other site 1114970007603 ATP binding site [chemical binding]; other site 1114970007604 Q-loop/lid; other site 1114970007605 ABC transporter signature motif; other site 1114970007606 Walker B; other site 1114970007607 D-loop; other site 1114970007608 H-loop/switch region; other site 1114970007609 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970007610 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1114970007611 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1114970007612 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1114970007613 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114970007614 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1114970007615 putative NAD(P) binding site [chemical binding]; other site 1114970007616 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1114970007617 classical (c) SDRs; Region: SDR_c; cd05233 1114970007618 NAD(P) binding site [chemical binding]; other site 1114970007619 active site 1114970007620 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1114970007621 FMN binding site [chemical binding]; other site 1114970007622 active site 1114970007623 substrate binding site [chemical binding]; other site 1114970007624 catalytic residue [active] 1114970007625 Helix-turn-helix domains; Region: HTH; cl00088 1114970007626 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970007627 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970007628 DNA binding site [nucleotide binding] 1114970007629 domain linker motif; other site 1114970007630 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1114970007631 putative dimerization interface [polypeptide binding]; other site 1114970007632 putative ligand binding site [chemical binding]; other site 1114970007633 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1114970007634 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1114970007635 substrate binding [chemical binding]; other site 1114970007636 active site 1114970007637 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1114970007638 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1114970007639 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1114970007640 Walker A/P-loop; other site 1114970007641 ATP binding site [chemical binding]; other site 1114970007642 Q-loop/lid; other site 1114970007643 ABC transporter signature motif; other site 1114970007644 Walker B; other site 1114970007645 D-loop; other site 1114970007646 H-loop/switch region; other site 1114970007647 TOBE domain; Region: TOBE_2; cl01440 1114970007648 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114970007649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970007650 dimer interface [polypeptide binding]; other site 1114970007651 putative PBP binding loops; other site 1114970007652 ABC-ATPase subunit interface; other site 1114970007653 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970007654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970007655 dimer interface [polypeptide binding]; other site 1114970007656 conserved gate region; other site 1114970007657 putative PBP binding loops; other site 1114970007658 ABC-ATPase subunit interface; other site 1114970007659 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114970007660 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970007661 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1114970007662 trimer interface; other site 1114970007663 sugar binding site [chemical binding]; other site 1114970007664 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 1114970007665 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1114970007666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970007667 PAS fold; Region: PAS_4; pfam08448 1114970007668 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970007669 metal binding site [ion binding]; metal-binding site 1114970007670 active site 1114970007671 I-site; other site 1114970007672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970007673 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970007674 active site 1114970007675 phosphorylation site [posttranslational modification] 1114970007676 intermolecular recognition site; other site 1114970007677 dimerization interface [polypeptide binding]; other site 1114970007678 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1114970007679 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970007680 metal binding site [ion binding]; metal-binding site 1114970007681 active site 1114970007682 I-site; other site 1114970007683 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970007684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970007685 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970007686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970007687 ATP binding site [chemical binding]; other site 1114970007688 Mg2+ binding site [ion binding]; other site 1114970007689 G-X-G motif; other site 1114970007690 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970007691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970007692 catalytic residue [active] 1114970007693 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1114970007694 FIST N domain; Region: FIST; cl10701 1114970007695 FIST C domain; Region: FIST_C; pfam10442 1114970007696 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970007697 dimer interface [polypeptide binding]; other site 1114970007698 putative CheW interface [polypeptide binding]; other site 1114970007699 putative S-transferase; Provisional; Region: PRK11752 1114970007700 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1114970007701 C-terminal domain interface [polypeptide binding]; other site 1114970007702 GSH binding site (G-site) [chemical binding]; other site 1114970007703 dimer interface [polypeptide binding]; other site 1114970007704 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1114970007705 dimer interface [polypeptide binding]; other site 1114970007706 N-terminal domain interface [polypeptide binding]; other site 1114970007707 active site 1114970007708 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970007709 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970007710 metal binding site [ion binding]; metal-binding site 1114970007711 active site 1114970007712 I-site; other site 1114970007713 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970007714 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970007715 substrate binding pocket [chemical binding]; other site 1114970007716 membrane-bound complex binding site; other site 1114970007717 hinge residues; other site 1114970007718 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970007719 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114970007720 active site 1114970007721 catalytic tetrad [active] 1114970007722 Helix-turn-helix domains; Region: HTH; cl00088 1114970007723 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970007724 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1114970007725 putative effector binding pocket; other site 1114970007726 putative dimerization interface [polypeptide binding]; other site 1114970007727 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114970007728 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970007729 NAD(P) binding site [chemical binding]; other site 1114970007730 catalytic residues [active] 1114970007731 PAS fold; Region: PAS_3; pfam08447 1114970007732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970007733 putative active site [active] 1114970007734 heme pocket [chemical binding]; other site 1114970007735 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970007736 dimer interface [polypeptide binding]; other site 1114970007737 putative CheW interface [polypeptide binding]; other site 1114970007738 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1114970007739 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1114970007740 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1114970007741 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1114970007742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970007743 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1114970007744 classical (c) SDRs; Region: SDR_c; cd05233 1114970007745 NAD(P) binding site [chemical binding]; other site 1114970007746 active site 1114970007747 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1114970007748 classical (c) SDRs; Region: SDR_c; cd05233 1114970007749 NAD(P) binding site [chemical binding]; other site 1114970007750 active site 1114970007751 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1114970007752 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970007753 DNA binding residues [nucleotide binding] 1114970007754 dimerization interface [polypeptide binding]; other site 1114970007755 Cupin domain; Region: Cupin_2; cl09118 1114970007756 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970007757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007758 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1114970007759 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970007760 Flavin binding site [chemical binding]; other site 1114970007761 Flavin Reductases; Region: FlaRed; cl00801 1114970007762 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1114970007763 HemN C-terminal domain; Region: HemN_C; pfam06969 1114970007764 Helix-turn-helix domains; Region: HTH; cl00088 1114970007765 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970007766 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1114970007767 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1114970007768 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970007769 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1114970007770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007771 putative substrate translocation pore; other site 1114970007772 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1114970007773 putative substrate binding pocket [chemical binding]; other site 1114970007774 trimer interface [polypeptide binding]; other site 1114970007775 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1114970007776 putative active site [active] 1114970007777 putative metal binding site [ion binding]; other site 1114970007778 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970007779 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1114970007780 NAD binding site [chemical binding]; other site 1114970007781 catalytic residues [active] 1114970007782 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1114970007783 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970007784 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970007785 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1114970007786 Cupin domain; Region: Cupin_2; cl09118 1114970007787 Cupin domain; Region: Cupin_2; cl09118 1114970007788 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970007789 Helix-turn-helix domains; Region: HTH; cl00088 1114970007790 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970007791 hypothetical protein; Provisional; Region: PRK09936 1114970007792 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 1114970007793 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 1114970007794 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970007795 active site 1114970007796 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1114970007797 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1114970007798 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1114970007799 active site 1114970007800 homodimer interface [polypeptide binding]; other site 1114970007801 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1114970007802 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1114970007803 DctM-like transporters; Region: DctM; pfam06808 1114970007804 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1114970007805 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1114970007806 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970007807 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970007808 substrate binding pocket [chemical binding]; other site 1114970007809 membrane-bound complex binding site; other site 1114970007810 hinge residues; other site 1114970007811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970007812 Helix-turn-helix domains; Region: HTH; cl00088 1114970007813 major facilitator superfamily transporter; Provisional; Region: PRK05122 1114970007814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007815 putative substrate translocation pore; other site 1114970007816 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1114970007817 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970007818 putative NAD(P) binding site [chemical binding]; other site 1114970007819 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970007820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970007821 active site 1114970007822 phosphorylation site [posttranslational modification] 1114970007823 intermolecular recognition site; other site 1114970007824 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970007825 DNA binding residues [nucleotide binding] 1114970007826 dimerization interface [polypeptide binding]; other site 1114970007827 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 1114970007828 Cache domain; Region: Cache_2; cl07034 1114970007829 Histidine kinase; Region: HisKA_3; pfam07730 1114970007830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970007831 ATP binding site [chemical binding]; other site 1114970007832 Mg2+ binding site [ion binding]; other site 1114970007833 G-X-G motif; other site 1114970007834 carbon starvation protein A; Provisional; Region: PRK15015 1114970007835 Carbon starvation protein CstA; Region: CstA; pfam02554 1114970007836 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1114970007837 Protein of unknown function (DUF466); Region: DUF466; cl01082 1114970007838 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1114970007839 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1114970007840 iron-sulfur cluster [ion binding]; other site 1114970007841 [2Fe-2S] cluster binding site [ion binding]; other site 1114970007842 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1114970007843 hydrophobic ligand binding site; other site 1114970007844 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1114970007845 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970007846 NAD binding site [chemical binding]; other site 1114970007847 catalytic residues [active] 1114970007848 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1114970007849 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1114970007850 active site 1114970007851 iron coordination sites [ion binding]; other site 1114970007852 substrate binding pocket [chemical binding]; other site 1114970007853 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1114970007854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970007855 DNA binding residues [nucleotide binding] 1114970007856 dimerization interface [polypeptide binding]; other site 1114970007857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007858 putative substrate translocation pore; other site 1114970007859 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1114970007860 choline dehydrogenase; Validated; Region: PRK02106 1114970007861 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970007862 Cupin domain; Region: Cupin_2; cl09118 1114970007863 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970007864 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1114970007865 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1114970007866 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1114970007867 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1114970007868 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970007869 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970007870 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1114970007871 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1114970007872 NADP binding site [chemical binding]; other site 1114970007873 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970007874 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970007875 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970007876 dimer interface [polypeptide binding]; other site 1114970007877 putative CheW interface [polypeptide binding]; other site 1114970007878 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 1114970007879 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1114970007880 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1114970007881 Na binding site [ion binding]; other site 1114970007882 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1114970007883 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970007884 N-terminal plug; other site 1114970007885 ligand-binding site [chemical binding]; other site 1114970007886 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1114970007887 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114970007888 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 1114970007889 Flavin Reductases; Region: FlaRed; cl00801 1114970007890 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970007891 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970007892 Walker A/P-loop; other site 1114970007893 ATP binding site [chemical binding]; other site 1114970007894 Q-loop/lid; other site 1114970007895 ABC transporter signature motif; other site 1114970007896 Walker B; other site 1114970007897 D-loop; other site 1114970007898 H-loop/switch region; other site 1114970007899 TOBE domain; Region: TOBE_2; cl01440 1114970007900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970007901 dimer interface [polypeptide binding]; other site 1114970007902 conserved gate region; other site 1114970007903 putative PBP binding loops; other site 1114970007904 ABC-ATPase subunit interface; other site 1114970007905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970007906 dimer interface [polypeptide binding]; other site 1114970007907 conserved gate region; other site 1114970007908 putative PBP binding loops; other site 1114970007909 ABC-ATPase subunit interface; other site 1114970007910 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1114970007911 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970007912 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485 1114970007913 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 1114970007914 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1114970007915 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1114970007916 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1114970007917 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1114970007918 nudix motif; other site 1114970007919 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970007920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970007921 DNA-binding site [nucleotide binding]; DNA binding site 1114970007922 FCD domain; Region: FCD; cl11656 1114970007923 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970007924 Flavin Reductases; Region: FlaRed; cl00801 1114970007925 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970007926 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1114970007927 NAD(P) binding site [chemical binding]; other site 1114970007928 catalytic residues [active] 1114970007929 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1114970007930 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970007931 Amino acid synthesis; Region: AA_synth; pfam06684 1114970007932 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970007933 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1114970007934 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970007935 N-terminal plug; other site 1114970007936 ligand-binding site [chemical binding]; other site 1114970007937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970007938 S-adenosylmethionine binding site [chemical binding]; other site 1114970007939 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1114970007940 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1114970007941 dimer interface [polypeptide binding]; other site 1114970007942 PYR/PP interface [polypeptide binding]; other site 1114970007943 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1114970007944 Predicted dehydrogenase [General function prediction only]; Region: COG5322 1114970007945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007946 NAD(P) binding pocket [chemical binding]; other site 1114970007947 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1114970007948 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970007949 inhibitor-cofactor binding pocket; inhibition site 1114970007950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970007951 catalytic residue [active] 1114970007952 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1114970007953 ATP binding site [chemical binding]; other site 1114970007954 substrate interface [chemical binding]; other site 1114970007955 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114970007956 active site residue [active] 1114970007957 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1114970007958 MPN+ (JAMM) motif; other site 1114970007959 Zinc-binding site [ion binding]; other site 1114970007960 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1114970007961 MoaE interaction surface [polypeptide binding]; other site 1114970007962 thiocarboxylated glycine; other site 1114970007963 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1114970007964 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1114970007965 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970007966 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970007967 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970007968 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1114970007969 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1114970007970 active site 1114970007971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007972 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1114970007973 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 1114970007974 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 1114970007975 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1114970007976 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1114970007977 DDE superfamily endonuclease; Region: DDE_4; cl15789 1114970007978 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970007979 Surface antigen; Region: Bac_surface_Ag; cl03097 1114970007980 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 1114970007981 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 1114970007982 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114970007983 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1114970007984 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1114970007985 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 1114970007986 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1114970007987 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1114970007988 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970007989 Helix-turn-helix domains; Region: HTH; cl00088 1114970007990 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970007991 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114970007992 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970007993 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1114970007994 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1114970007995 dimer interface [polypeptide binding]; other site 1114970007996 catalytic triad [active] 1114970007997 peroxidatic and resolving cysteines [active] 1114970007998 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1114970007999 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970008000 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970008001 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1114970008002 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970008003 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1114970008004 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970008005 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970008006 enoyl-CoA hydratase; Provisional; Region: PRK06142 1114970008007 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970008008 substrate binding site [chemical binding]; other site 1114970008009 oxyanion hole (OAH) forming residues; other site 1114970008010 trimer interface [polypeptide binding]; other site 1114970008011 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1114970008012 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1114970008013 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1114970008014 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1114970008015 putative NADH binding site [chemical binding]; other site 1114970008016 putative active site [active] 1114970008017 nudix motif; other site 1114970008018 putative metal binding site [ion binding]; other site 1114970008019 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1114970008020 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114970008021 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 1114970008022 nudix motif; other site 1114970008023 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1114970008024 NodB motif; other site 1114970008025 active site 1114970008026 catalytic site [active] 1114970008027 metal binding site [ion binding]; metal-binding site 1114970008028 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 1114970008029 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1114970008030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970008031 ATP binding site [chemical binding]; other site 1114970008032 G-X-G motif; other site 1114970008033 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1114970008034 YccA-like proteins; Region: YccA_like; cd10433 1114970008035 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1114970008036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970008037 putative substrate translocation pore; other site 1114970008038 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970008039 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970008040 Helix-turn-helix domains; Region: HTH; cl00088 1114970008041 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 1114970008042 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970008043 substrate binding site [chemical binding]; other site 1114970008044 oxyanion hole (OAH) forming residues; other site 1114970008045 trimer interface [polypeptide binding]; other site 1114970008046 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970008047 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 1114970008048 NAD(P) binding site [chemical binding]; other site 1114970008049 catalytic residues [active] 1114970008050 feruloyl-CoA synthase; Reviewed; Region: PRK08180 1114970008051 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970008052 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1114970008053 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970008054 Helix-turn-helix domains; Region: HTH; cl00088 1114970008055 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1114970008056 putative substrate binding pocket [chemical binding]; other site 1114970008057 putative dimerization interface [polypeptide binding]; other site 1114970008058 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1114970008059 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114970008060 putative active site [active] 1114970008061 catalytic triad [active] 1114970008062 putative dimer interface [polypeptide binding]; other site 1114970008063 Late embryogenesis abundant protein; Region: LEA_2; cl12118 1114970008064 Helix-turn-helix domains; Region: HTH; cl00088 1114970008065 WYL domain; Region: WYL; cl14852 1114970008066 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970008067 Predicted ATPase [General function prediction only]; Region: COG1485 1114970008068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970008069 Coenzyme A binding pocket [chemical binding]; other site 1114970008070 hypothetical protein; Provisional; Region: PRK10649 1114970008071 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1114970008072 Sulfatase; Region: Sulfatase; cl10460 1114970008073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008074 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1114970008075 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1114970008076 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1114970008077 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1114970008078 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114970008079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970008080 active site 1114970008081 motif I; other site 1114970008082 motif II; other site 1114970008083 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114970008084 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1114970008085 transmembrane helices; other site 1114970008086 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970008087 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970008088 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970008089 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970008090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970008091 Walker A motif; other site 1114970008092 ATP binding site [chemical binding]; other site 1114970008093 Walker B motif; other site 1114970008094 arginine finger; other site 1114970008095 Helix-turn-helix domains; Region: HTH; cl00088 1114970008096 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1114970008097 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39G; cd02423 1114970008098 putative active site [active] 1114970008099 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970008100 AAA domain; Region: AAA_28; pfam13521 1114970008101 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1114970008102 Cache domain; Region: Cache_2; cl07034 1114970008103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970008104 dimerization interface [polypeptide binding]; other site 1114970008105 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970008106 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970008107 dimer interface [polypeptide binding]; other site 1114970008108 putative CheW interface [polypeptide binding]; other site 1114970008109 Bacitracin resistance protein BacA; Region: BacA; cl00858 1114970008110 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 1114970008111 Protein of unknown function (DUF419); Region: DUF419; cl15265 1114970008112 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970008113 Helix-turn-helix domains; Region: HTH; cl00088 1114970008114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970008115 dimerization interface [polypeptide binding]; other site 1114970008116 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970008117 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1114970008118 major facilitator superfamily transporter; Provisional; Region: PRK05122 1114970008119 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1114970008120 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970008121 Walker A/P-loop; other site 1114970008122 ATP binding site [chemical binding]; other site 1114970008123 Q-loop/lid; other site 1114970008124 ABC transporter signature motif; other site 1114970008125 Walker B; other site 1114970008126 D-loop; other site 1114970008127 H-loop/switch region; other site 1114970008128 ABC transporter; Region: ABC_tran_2; pfam12848 1114970008129 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114970008130 Cupin domain; Region: Cupin_2; cl09118 1114970008131 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1114970008132 active site 1114970008133 DNA binding site [nucleotide binding] 1114970008134 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 1114970008135 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1114970008136 DNA binding site [nucleotide binding] 1114970008137 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1114970008138 nucleotide binding site [chemical binding]; other site 1114970008139 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1114970008140 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1114970008141 putative DNA binding site [nucleotide binding]; other site 1114970008142 putative homodimer interface [polypeptide binding]; other site 1114970008143 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1114970008144 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1114970008145 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1114970008146 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1114970008147 tetramer interface [polypeptide binding]; other site 1114970008148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970008149 catalytic residue [active] 1114970008150 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1114970008151 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114970008152 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1114970008153 putative substrate binding site [chemical binding]; other site 1114970008154 putative ATP binding site [chemical binding]; other site 1114970008155 D-xylulose kinases, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 1114970008156 N- and C-terminal domain interface [polypeptide binding]; other site 1114970008157 D-xylulose kinase; Region: XylB; TIGR01312 1114970008158 active site 1114970008159 catalytic site [active] 1114970008160 metal binding site [ion binding]; metal-binding site 1114970008161 xylulose binding site [chemical binding]; other site 1114970008162 ATP binding site [chemical binding]; other site 1114970008163 putative homodimer interface [polypeptide binding]; other site 1114970008164 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1114970008165 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1114970008166 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1114970008167 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1114970008168 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1114970008169 Walker A/P-loop; other site 1114970008170 ATP binding site [chemical binding]; other site 1114970008171 Q-loop/lid; other site 1114970008172 ABC transporter signature motif; other site 1114970008173 Walker B; other site 1114970008174 D-loop; other site 1114970008175 H-loop/switch region; other site 1114970008176 TOBE domain; Region: TOBE_2; cl01440 1114970008177 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114970008178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008179 dimer interface [polypeptide binding]; other site 1114970008180 conserved gate region; other site 1114970008181 putative PBP binding loops; other site 1114970008182 ABC-ATPase subunit interface; other site 1114970008183 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 1114970008184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008185 putative PBP binding loops; other site 1114970008186 ABC-ATPase subunit interface; other site 1114970008187 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114970008188 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970008189 Cupin domain; Region: Cupin_2; cl09118 1114970008190 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970008191 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970008192 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970008193 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970008194 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970008195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008196 active site 1114970008197 phosphorylation site [posttranslational modification] 1114970008198 intermolecular recognition site; other site 1114970008199 dimerization interface [polypeptide binding]; other site 1114970008200 CHASE3 domain; Region: CHASE3; cl05000 1114970008201 GAF domain; Region: GAF_2; pfam13185 1114970008202 GAF domain; Region: GAF; cl15785 1114970008203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970008204 dimer interface [polypeptide binding]; other site 1114970008205 phosphorylation site [posttranslational modification] 1114970008206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970008207 ATP binding site [chemical binding]; other site 1114970008208 Mg2+ binding site [ion binding]; other site 1114970008209 G-X-G motif; other site 1114970008210 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970008211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008212 active site 1114970008213 phosphorylation site [posttranslational modification] 1114970008214 intermolecular recognition site; other site 1114970008215 dimerization interface [polypeptide binding]; other site 1114970008216 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970008217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008218 active site 1114970008219 phosphorylation site [posttranslational modification] 1114970008220 intermolecular recognition site; other site 1114970008221 dimerization interface [polypeptide binding]; other site 1114970008222 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970008223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008224 active site 1114970008225 phosphorylation site [posttranslational modification] 1114970008226 intermolecular recognition site; other site 1114970008227 dimerization interface [polypeptide binding]; other site 1114970008228 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1114970008229 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1114970008230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970008231 CheB methylesterase; Region: CheB_methylest; pfam01339 1114970008232 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970008233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008234 active site 1114970008235 phosphorylation site [posttranslational modification] 1114970008236 intermolecular recognition site; other site 1114970008237 dimerization interface [polypeptide binding]; other site 1114970008238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970008239 dimer interface [polypeptide binding]; other site 1114970008240 phosphorylation site [posttranslational modification] 1114970008241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970008242 ATP binding site [chemical binding]; other site 1114970008243 Mg2+ binding site [ion binding]; other site 1114970008244 G-X-G motif; other site 1114970008245 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970008246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008247 active site 1114970008248 phosphorylation site [posttranslational modification] 1114970008249 intermolecular recognition site; other site 1114970008250 dimerization interface [polypeptide binding]; other site 1114970008251 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970008252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114970008253 dimer interface [polypeptide binding]; other site 1114970008254 phosphorylation site [posttranslational modification] 1114970008255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970008256 ATP binding site [chemical binding]; other site 1114970008257 Mg2+ binding site [ion binding]; other site 1114970008258 G-X-G motif; other site 1114970008259 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970008260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008261 active site 1114970008262 phosphorylation site [posttranslational modification] 1114970008263 intermolecular recognition site; other site 1114970008264 dimerization interface [polypeptide binding]; other site 1114970008265 circadian clock protein KaiC; Reviewed; Region: PRK09302 1114970008266 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970008267 Walker A motif; other site 1114970008268 ATP binding site [chemical binding]; other site 1114970008269 Walker B motif; other site 1114970008270 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970008271 Walker A motif; other site 1114970008272 ATP binding site [chemical binding]; other site 1114970008273 Walker B motif; other site 1114970008274 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1114970008275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114970008276 TPR motif; other site 1114970008277 binding surface 1114970008278 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970008279 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1114970008280 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970008281 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970008282 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970008283 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970008284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 1114970008285 substrate binding pocket [chemical binding]; other site 1114970008286 membrane-bound complex binding site; other site 1114970008287 hinge residues; other site 1114970008288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970008289 Helix-turn-helix domains; Region: HTH; cl00088 1114970008290 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 1114970008291 putative dimerization interface [polypeptide binding]; other site 1114970008292 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1114970008293 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970008294 putative metal binding site [ion binding]; other site 1114970008295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970008296 Helix-turn-helix domains; Region: HTH; cl00088 1114970008297 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1114970008298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008299 NAD(P) binding site [chemical binding]; other site 1114970008300 active site 1114970008301 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970008302 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970008303 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970008304 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970008305 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1114970008306 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 1114970008307 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114970008308 dimer interface [polypeptide binding]; other site 1114970008309 active site 1114970008310 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 1114970008311 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114970008312 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 1114970008313 Walker A/P-loop; other site 1114970008314 ATP binding site [chemical binding]; other site 1114970008315 Q-loop/lid; other site 1114970008316 ABC transporter signature motif; other site 1114970008317 Walker B; other site 1114970008318 D-loop; other site 1114970008319 H-loop/switch region; other site 1114970008320 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1114970008321 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970008322 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970008323 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1114970008324 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1114970008325 active site 1114970008326 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970008327 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970008328 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1114970008329 NADP binding site [chemical binding]; other site 1114970008330 dimer interface [polypeptide binding]; other site 1114970008331 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1114970008332 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114970008333 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970008334 NAD(P) binding site [chemical binding]; other site 1114970008335 catalytic residues [active] 1114970008336 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1114970008337 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970008338 inhibitor-cofactor binding pocket; inhibition site 1114970008339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970008340 catalytic residue [active] 1114970008341 transcriptional regulator EutR; Provisional; Region: PRK10130 1114970008342 Amino acid permease; Region: AA_permease; pfam00324 1114970008343 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1114970008344 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114970008345 universal stress protein UspE; Provisional; Region: PRK11175 1114970008346 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970008347 Ligand Binding Site [chemical binding]; other site 1114970008348 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970008349 Ligand Binding Site [chemical binding]; other site 1114970008350 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970008351 active site 1114970008352 Possible frameshift 1114970008353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970008354 non-specific DNA binding site [nucleotide binding]; other site 1114970008355 salt bridge; other site 1114970008356 sequence-specific DNA binding site [nucleotide binding]; other site 1114970008357 HipA N-terminal domain; Region: Couple_hipA; cl11853 1114970008358 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1114970008359 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1114970008360 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1114970008361 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1114970008362 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1114970008363 putative NADP binding site [chemical binding]; other site 1114970008364 putative substrate binding site [chemical binding]; other site 1114970008365 active site 1114970008366 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1114970008367 DNA binding residues [nucleotide binding] 1114970008368 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114970008369 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970008370 non-specific DNA binding site [nucleotide binding]; other site 1114970008371 salt bridge; other site 1114970008372 sequence-specific DNA binding site [nucleotide binding]; other site 1114970008373 Cupin domain; Region: Cupin_2; cl09118 1114970008374 B3/4 domain; Region: B3_4; cl11458 1114970008375 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1114970008376 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1114970008377 inhibitor site; inhibition site 1114970008378 active site 1114970008379 dimer interface [polypeptide binding]; other site 1114970008380 catalytic residue [active] 1114970008381 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1114970008382 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1114970008383 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1114970008384 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970008385 catalytic residue [active] 1114970008386 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970008387 homoserine dehydrogenase; Provisional; Region: PRK06270 1114970008388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008389 NAD(P) binding pocket [chemical binding]; other site 1114970008390 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1114970008391 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970008392 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1114970008393 NAD(P) binding site [chemical binding]; other site 1114970008394 catalytic residues [active] 1114970008395 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1114970008396 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1114970008397 homodimer interface [polypeptide binding]; other site 1114970008398 substrate-cofactor binding pocket; other site 1114970008399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970008400 catalytic residue [active] 1114970008401 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114970008402 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1114970008403 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970008404 substrate binding pocket [chemical binding]; other site 1114970008405 membrane-bound complex binding site; other site 1114970008406 hinge residues; other site 1114970008407 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970008408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008409 dimer interface [polypeptide binding]; other site 1114970008410 conserved gate region; other site 1114970008411 putative PBP binding loops; other site 1114970008412 ABC-ATPase subunit interface; other site 1114970008413 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970008414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008415 dimer interface [polypeptide binding]; other site 1114970008416 conserved gate region; other site 1114970008417 putative PBP binding loops; other site 1114970008418 ABC-ATPase subunit interface; other site 1114970008419 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1114970008420 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970008421 Walker A/P-loop; other site 1114970008422 ATP binding site [chemical binding]; other site 1114970008423 Q-loop/lid; other site 1114970008424 ABC transporter signature motif; other site 1114970008425 Walker B; other site 1114970008426 D-loop; other site 1114970008427 H-loop/switch region; other site 1114970008428 Cache domain; Region: Cache_1; pfam02743 1114970008429 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970008430 dimerization interface [polypeptide binding]; other site 1114970008431 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970008432 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970008433 dimer interface [polypeptide binding]; other site 1114970008434 putative CheW interface [polypeptide binding]; other site 1114970008435 LysE type translocator; Region: LysE; cl00565 1114970008436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970008437 Helix-turn-helix domains; Region: HTH; cl00088 1114970008438 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1114970008439 putative substrate binding pocket [chemical binding]; other site 1114970008440 putative dimerization interface [polypeptide binding]; other site 1114970008441 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1114970008442 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114970008443 putative NAD(P) binding site [chemical binding]; other site 1114970008444 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970008445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970008446 DNA-binding site [nucleotide binding]; DNA binding site 1114970008447 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970008448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970008449 homodimer interface [polypeptide binding]; other site 1114970008450 catalytic residue [active] 1114970008451 phosphoglucomutase; Validated; Region: PRK07564 1114970008452 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1114970008453 active site 1114970008454 substrate binding site [chemical binding]; other site 1114970008455 metal binding site [ion binding]; metal-binding site 1114970008456 Pirin-related protein [General function prediction only]; Region: COG1741 1114970008457 Cupin domain; Region: Cupin_2; cl09118 1114970008458 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1114970008459 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1114970008460 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1114970008461 Family description; Region: UvrD_C_2; cl15862 1114970008462 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970008463 Helix-turn-helix domains; Region: HTH; cl00088 1114970008464 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970008465 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114970008466 EamA-like transporter family; Region: EamA; cl01037 1114970008467 EamA-like transporter family; Region: EamA; cl01037 1114970008468 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1114970008469 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970008470 tetrameric interface [polypeptide binding]; other site 1114970008471 activator binding site; other site 1114970008472 NADP binding site [chemical binding]; other site 1114970008473 substrate binding site [chemical binding]; other site 1114970008474 catalytic residues [active] 1114970008475 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1114970008476 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1114970008477 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1114970008478 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1114970008479 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1114970008480 putative catalytic site [active] 1114970008481 putative metal binding site [ion binding]; other site 1114970008482 putative phosphate binding site [ion binding]; other site 1114970008483 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1114970008484 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1114970008485 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1114970008486 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1114970008487 active site 1114970008488 catalytic site [active] 1114970008489 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1114970008490 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1114970008491 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1114970008492 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1114970008493 active site 1114970008494 catalytic site [active] 1114970008495 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1114970008496 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1114970008497 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1114970008498 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1114970008499 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1114970008500 catalytic site [active] 1114970008501 active site 1114970008502 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1114970008503 glycogen synthase; Provisional; Region: glgA; PRK00654 1114970008504 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1114970008505 ADP-binding pocket [chemical binding]; other site 1114970008506 homodimer interface [polypeptide binding]; other site 1114970008507 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1114970008508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008509 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970008510 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970008511 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114970008512 Protein of unknown function, DUF; Region: DUF411; cl01142 1114970008513 Helix-turn-helix domains; Region: HTH; cl00088 1114970008514 Penicillin amidase; Region: Penicil_amidase; pfam01804 1114970008515 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1114970008516 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1114970008517 active site 1114970008518 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1114970008519 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970008520 FecR protein; Region: FecR; pfam04773 1114970008521 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1114970008522 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970008523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970008524 DNA-binding site [nucleotide binding]; DNA binding site 1114970008525 FCD domain; Region: FCD; cl11656 1114970008526 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1114970008527 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1114970008528 FMN-binding pocket [chemical binding]; other site 1114970008529 flavin binding motif; other site 1114970008530 phosphate binding motif [ion binding]; other site 1114970008531 beta-alpha-beta structure motif; other site 1114970008532 NAD binding pocket [chemical binding]; other site 1114970008533 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970008534 catalytic loop [active] 1114970008535 iron binding site [ion binding]; other site 1114970008536 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1114970008537 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1114970008538 iron-sulfur cluster [ion binding]; other site 1114970008539 [2Fe-2S] cluster binding site [ion binding]; other site 1114970008540 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1114970008541 alpha subunit interface [polypeptide binding]; other site 1114970008542 active site 1114970008543 substrate binding site [chemical binding]; other site 1114970008544 Fe binding site [ion binding]; other site 1114970008545 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1114970008546 Helix-turn-helix domains; Region: HTH; cl00088 1114970008547 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1114970008548 putative dimerization interface [polypeptide binding]; other site 1114970008549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008550 FAD dependent oxidoreductase; Region: DAO; pfam01266 1114970008551 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1114970008552 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1114970008553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008554 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1114970008555 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1114970008556 homotrimer interaction site [polypeptide binding]; other site 1114970008557 putative active site [active] 1114970008558 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1114970008559 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970008560 substrate binding pocket [chemical binding]; other site 1114970008561 membrane-bound complex binding site; other site 1114970008562 hinge residues; other site 1114970008563 Domain of unknown function (DUF336); Region: DUF336; cl01249 1114970008564 Cupin domain; Region: Cupin_2; cl09118 1114970008565 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970008566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970008567 LysE type translocator; Region: LysE; cl00565 1114970008568 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1114970008569 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970008570 NAD binding site [chemical binding]; other site 1114970008571 catalytic residues [active] 1114970008572 substrate binding site [chemical binding]; other site 1114970008573 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1114970008574 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1114970008575 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1114970008576 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1114970008577 putative active site pocket [active] 1114970008578 putative metal binding site [ion binding]; other site 1114970008579 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1114970008580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970008581 putative substrate translocation pore; other site 1114970008582 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1114970008583 Helix-turn-helix domains; Region: HTH; cl00088 1114970008584 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1114970008585 putative dimerization interface [polypeptide binding]; other site 1114970008586 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1114970008587 Leucine-rich repeats; other site 1114970008588 Substrate binding site [chemical binding]; other site 1114970008589 Leucine rich repeat; Region: LRR_8; pfam13855 1114970008590 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 1114970008591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970008592 S-adenosylmethionine binding site [chemical binding]; other site 1114970008593 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 1114970008594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1114970008595 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1114970008596 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970008597 Helix-turn-helix domains; Region: HTH; cl00088 1114970008598 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1114970008599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008600 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970008601 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1114970008602 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114970008603 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1114970008604 FOG: CBS domain [General function prediction only]; Region: COG0517 1114970008605 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1114970008606 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970008607 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970008608 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970008609 metal binding site [ion binding]; metal-binding site 1114970008610 active site 1114970008611 I-site; other site 1114970008612 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1114970008613 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1114970008614 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970008615 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247 1114970008616 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247 1114970008617 Phytase; Region: Phytase; pfam02333 1114970008618 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114970008619 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1114970008620 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1114970008621 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970008622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008623 active site 1114970008624 phosphorylation site [posttranslational modification] 1114970008625 intermolecular recognition site; other site 1114970008626 dimerization interface [polypeptide binding]; other site 1114970008627 CHASE3 domain; Region: CHASE3; cl05000 1114970008628 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1114970008629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970008630 putative active site [active] 1114970008631 heme pocket [chemical binding]; other site 1114970008632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970008633 dimer interface [polypeptide binding]; other site 1114970008634 phosphorylation site [posttranslational modification] 1114970008635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970008636 ATP binding site [chemical binding]; other site 1114970008637 G-X-G motif; other site 1114970008638 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970008639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008640 active site 1114970008641 phosphorylation site [posttranslational modification] 1114970008642 intermolecular recognition site; other site 1114970008643 dimerization interface [polypeptide binding]; other site 1114970008644 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970008645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008646 active site 1114970008647 phosphorylation site [posttranslational modification] 1114970008648 intermolecular recognition site; other site 1114970008649 dimerization interface [polypeptide binding]; other site 1114970008650 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1114970008651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970008652 DNA binding residues [nucleotide binding] 1114970008653 dimerization interface [polypeptide binding]; other site 1114970008654 Sensor protein DegS, frameshift 1114970008655 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970008656 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970008657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970008658 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970008659 FecR protein; Region: FecR; pfam04773 1114970008660 Secretin and TonB N terminus short domain; Region: STN; cl06624 1114970008661 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970008662 N-terminal plug; other site 1114970008663 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1114970008664 ligand-binding site [chemical binding]; other site 1114970008665 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1114970008666 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970008667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970008668 Helix-turn-helix domains; Region: HTH; cl00088 1114970008669 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1114970008670 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1114970008671 domain interface [polypeptide binding]; other site 1114970008672 putative active site [active] 1114970008673 catalytic site [active] 1114970008674 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1114970008675 domain interface [polypeptide binding]; other site 1114970008676 putative active site [active] 1114970008677 catalytic site [active] 1114970008678 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970008679 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1114970008680 Helix-turn-helix domains; Region: HTH; cl00088 1114970008681 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970008682 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970008683 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1114970008684 putative NAD(P) binding site [chemical binding]; other site 1114970008685 active site 1114970008686 putative substrate binding site [chemical binding]; other site 1114970008687 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1114970008688 Ligand binding site; other site 1114970008689 DXD motif; other site 1114970008690 Putative Catalytic site; other site 1114970008691 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 1114970008692 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1114970008693 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1114970008694 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970008695 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970008696 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114970008697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008698 NAD(P) binding site [chemical binding]; other site 1114970008699 active site 1114970008700 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1114970008701 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970008702 dimer interface [polypeptide binding]; other site 1114970008703 active site 1114970008704 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970008705 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970008706 active site 1114970008707 enoyl-CoA hydratase; Provisional; Region: PRK05862 1114970008708 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970008709 substrate binding site [chemical binding]; other site 1114970008710 oxyanion hole (OAH) forming residues; other site 1114970008711 trimer interface [polypeptide binding]; other site 1114970008712 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970008713 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970008714 active site 1114970008715 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1114970008716 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970008717 substrate binding site [chemical binding]; other site 1114970008718 oxyanion hole (OAH) forming residues; other site 1114970008719 trimer interface [polypeptide binding]; other site 1114970008720 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1114970008721 HPP family; Region: HPP; pfam04982 1114970008722 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1114970008723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008724 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114970008725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008726 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1114970008727 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1114970008728 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114970008729 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1114970008730 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114970008731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970008732 S-adenosylmethionine binding site [chemical binding]; other site 1114970008733 LysE type translocator; Region: LysE; cl00565 1114970008734 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1114970008735 homotrimer interaction site [polypeptide binding]; other site 1114970008736 putative active site [active] 1114970008737 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970008738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008739 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1114970008740 Amidase; Region: Amidase; cl11426 1114970008741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970008742 Helix-turn-helix domains; Region: HTH; cl00088 1114970008743 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1114970008744 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1114970008745 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970008746 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970008747 Integrase core domain; Region: rve; cl01316 1114970008748 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970008749 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970008750 Helix-turn-helix domains; Region: HTH; cl00088 1114970008751 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970008752 DNA binding residues [nucleotide binding] 1114970008753 dimerization interface [polypeptide binding]; other site 1114970008754 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1114970008755 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970008756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970008757 putative substrate translocation pore; other site 1114970008758 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 1114970008759 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 1114970008760 ATP/ADP translocase [Energy production and conversion]; Region: COG3202; cl03940 1114970008761 ATP/ADP translocase [Energy production and conversion]; Region: COG3202; cl03940 1114970008762 short chain dehydrogenase; Provisional; Region: PRK06197 1114970008763 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1114970008764 putative NAD(P) binding site [chemical binding]; other site 1114970008765 active site 1114970008766 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1114970008767 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1114970008768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970008769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970008770 dimer interface [polypeptide binding]; other site 1114970008771 phosphorylation site [posttranslational modification] 1114970008772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970008773 ATP binding site [chemical binding]; other site 1114970008774 Mg2+ binding site [ion binding]; other site 1114970008775 G-X-G motif; other site 1114970008776 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1114970008777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008778 active site 1114970008779 phosphorylation site [posttranslational modification] 1114970008780 intermolecular recognition site; other site 1114970008781 dimerization interface [polypeptide binding]; other site 1114970008782 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970008783 DNA binding site [nucleotide binding] 1114970008784 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1114970008785 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1114970008786 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970008787 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 1114970008788 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1114970008789 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1114970008790 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1114970008791 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970008792 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 1114970008793 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1114970008794 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1114970008795 conserved hypothetical protein; Region: TIGR02270 1114970008796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008797 active site 1114970008798 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970008799 benzoate transport; Region: 2A0115; TIGR00895 1114970008800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970008801 putative substrate translocation pore; other site 1114970008802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970008803 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970008804 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 1114970008805 putative NAD(P) binding site [chemical binding]; other site 1114970008806 active site 1114970008807 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1114970008808 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970008809 catalytic loop [active] 1114970008810 iron binding site [ion binding]; other site 1114970008811 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1114970008812 FAD binding pocket [chemical binding]; other site 1114970008813 FAD binding motif [chemical binding]; other site 1114970008814 phosphate binding motif [ion binding]; other site 1114970008815 beta-alpha-beta structure motif; other site 1114970008816 NAD binding pocket [chemical binding]; other site 1114970008817 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1114970008818 inter-subunit interface; other site 1114970008819 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1114970008820 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 1114970008821 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1114970008822 putative alpha subunit interface [polypeptide binding]; other site 1114970008823 putative active site [active] 1114970008824 putative substrate binding site [chemical binding]; other site 1114970008825 Fe binding site [ion binding]; other site 1114970008826 Cupin domain; Region: Cupin_2; cl09118 1114970008827 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970008828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970008829 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1114970008830 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 1114970008831 dimer interface [polypeptide binding]; other site 1114970008832 active site 1114970008833 Muconolactone delta-isomerase; Region: MIase; cl01992 1114970008834 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 1114970008835 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1114970008836 octamer interface [polypeptide binding]; other site 1114970008837 active site 1114970008838 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1114970008839 Helix-turn-helix domains; Region: HTH; cl00088 1114970008840 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 1114970008841 dimerizarion interface [polypeptide binding]; other site 1114970008842 CrgA pocket; other site 1114970008843 substrate binding pocket [chemical binding]; other site 1114970008844 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970008845 Helix-turn-helix domains; Region: HTH; cl00088 1114970008846 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1114970008847 putative effector binding pocket; other site 1114970008848 putative dimerization interface [polypeptide binding]; other site 1114970008849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970008850 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970008851 putative substrate translocation pore; other site 1114970008852 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1114970008853 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 1114970008854 metal binding site [ion binding]; metal-binding site 1114970008855 putative dimer interface [polypeptide binding]; other site 1114970008856 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970008857 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1114970008858 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1114970008859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008860 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970008861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970008862 homodimer interface [polypeptide binding]; other site 1114970008863 catalytic residue [active] 1114970008864 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1114970008865 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970008866 non-specific DNA binding site [nucleotide binding]; other site 1114970008867 salt bridge; other site 1114970008868 sequence-specific DNA binding site [nucleotide binding]; other site 1114970008869 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970008870 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970008871 DNA binding site [nucleotide binding] 1114970008872 domain linker motif; other site 1114970008873 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 1114970008874 putative dimerization interface [polypeptide binding]; other site 1114970008875 putative ligand binding site [chemical binding]; other site 1114970008876 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1114970008877 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970008878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008879 dimer interface [polypeptide binding]; other site 1114970008880 conserved gate region; other site 1114970008881 putative PBP binding loops; other site 1114970008882 ABC-ATPase subunit interface; other site 1114970008883 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970008884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008885 dimer interface [polypeptide binding]; other site 1114970008886 conserved gate region; other site 1114970008887 putative PBP binding loops; other site 1114970008888 ABC-ATPase subunit interface; other site 1114970008889 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970008890 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970008891 Walker A/P-loop; other site 1114970008892 ATP binding site [chemical binding]; other site 1114970008893 Q-loop/lid; other site 1114970008894 ABC transporter signature motif; other site 1114970008895 Walker B; other site 1114970008896 D-loop; other site 1114970008897 H-loop/switch region; other site 1114970008898 TOBE domain; Region: TOBE_2; cl01440 1114970008899 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1114970008900 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114970008901 active site 1114970008902 metal binding site [ion binding]; metal-binding site 1114970008903 hexamer interface [polypeptide binding]; other site 1114970008904 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970008905 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1114970008906 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1114970008907 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1114970008908 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1114970008909 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970008910 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970008911 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1114970008912 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970008913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970008914 Flagellin N-methylase; Region: FliB; cl00497 1114970008915 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970008916 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970008917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970008918 dimer interface [polypeptide binding]; other site 1114970008919 putative CheW interface [polypeptide binding]; other site 1114970008920 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1114970008921 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970008922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970008923 homodimer interface [polypeptide binding]; other site 1114970008924 catalytic residue [active] 1114970008925 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1114970008926 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970008927 short chain dehydrogenase; Provisional; Region: PRK06701 1114970008928 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1114970008929 NAD binding site [chemical binding]; other site 1114970008930 metal binding site [ion binding]; metal-binding site 1114970008931 active site 1114970008932 Protein of unknown function (DUF421); Region: DUF421; cl00990 1114970008933 Competence-damaged protein; Region: CinA; cl00666 1114970008934 Yip1 domain; Region: Yip1; cl12048 1114970008935 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 1114970008936 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 1114970008937 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1114970008938 active site 1114970008939 DNA binding site [nucleotide binding] 1114970008940 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1114970008941 DNA binding site [nucleotide binding] 1114970008942 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1114970008943 nucleotide binding site [chemical binding]; other site 1114970008944 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1114970008945 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1114970008946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970008947 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1114970008948 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1114970008949 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970008950 PAS domain; Region: PAS_9; pfam13426 1114970008951 putative active site [active] 1114970008952 heme pocket [chemical binding]; other site 1114970008953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970008954 dimer interface [polypeptide binding]; other site 1114970008955 phosphorylation site [posttranslational modification] 1114970008956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970008957 ATP binding site [chemical binding]; other site 1114970008958 Mg2+ binding site [ion binding]; other site 1114970008959 G-X-G motif; other site 1114970008960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008961 active site 1114970008962 phosphorylation site [posttranslational modification] 1114970008963 intermolecular recognition site; other site 1114970008964 dimerization interface [polypeptide binding]; other site 1114970008965 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1114970008966 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970008967 DEAD_2; Region: DEAD_2; pfam06733 1114970008968 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970008969 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1114970008970 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1114970008971 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 1114970008972 nucleophilic elbow; other site 1114970008973 catalytic triad; other site 1114970008974 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970008975 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1114970008976 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1114970008977 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970008978 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970008979 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 1114970008980 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 1114970008981 Walker A/P-loop; other site 1114970008982 ATP binding site [chemical binding]; other site 1114970008983 Q-loop/lid; other site 1114970008984 ABC transporter signature motif; other site 1114970008985 Walker B; other site 1114970008986 D-loop; other site 1114970008987 H-loop/switch region; other site 1114970008988 Protease inhibitor Inh; Region: Inh; pfam02974 1114970008989 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1114970008990 active site 1114970008991 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970008992 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970008993 Helix-turn-helix domains; Region: HTH; cl00088 1114970008994 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1114970008995 putative substrate binding pocket [chemical binding]; other site 1114970008996 putative dimerization interface [polypeptide binding]; other site 1114970008997 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970008998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970008999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970009000 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1114970009001 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1114970009002 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1114970009003 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1114970009004 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1114970009005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009006 NAD(P) binding site [chemical binding]; other site 1114970009007 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 1114970009008 active site 1114970009009 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970009010 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 1114970009011 NAD(P) binding site [chemical binding]; other site 1114970009012 catalytic residues [active] 1114970009013 Activator of aromatic catabolism; Region: XylR_N; pfam06505 1114970009014 Heme NO binding; Region: HNOB; cl15268 1114970009015 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970009016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970009017 Walker A motif; other site 1114970009018 ATP binding site [chemical binding]; other site 1114970009019 Walker B motif; other site 1114970009020 arginine finger; other site 1114970009021 Cupin domain; Region: Cupin_2; cl09118 1114970009022 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970009023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970009024 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114970009025 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970009026 sorbitol dehydrogenase; Provisional; Region: PRK07067 1114970009027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009028 NAD(P) binding site [chemical binding]; other site 1114970009029 active site 1114970009030 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1114970009031 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1114970009032 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009033 Helix-turn-helix domains; Region: HTH; cl00088 1114970009034 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1114970009035 putative dimerization interface [polypeptide binding]; other site 1114970009036 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1114970009037 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1114970009038 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1114970009039 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 1114970009040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009041 Predicted transcriptional regulator [Transcription]; Region: COG1959 1114970009042 Helix-turn-helix domains; Region: HTH; cl00088 1114970009043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009044 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1114970009045 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1114970009046 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1114970009047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009048 dimer interface [polypeptide binding]; other site 1114970009049 phosphorylation site [posttranslational modification] 1114970009050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009051 ATP binding site [chemical binding]; other site 1114970009052 G-X-G motif; other site 1114970009053 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970009054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009055 active site 1114970009056 phosphorylation site [posttranslational modification] 1114970009057 intermolecular recognition site; other site 1114970009058 dimerization interface [polypeptide binding]; other site 1114970009059 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 1114970009060 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1114970009061 putative active site [active] 1114970009062 metal binding site [ion binding]; metal-binding site 1114970009063 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114970009064 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970009065 NAD(P) binding site [chemical binding]; other site 1114970009066 catalytic residues [active] 1114970009067 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1114970009068 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1114970009069 dimer interface [polypeptide binding]; other site 1114970009070 Trp docking motif [polypeptide binding]; other site 1114970009071 active site 1114970009072 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970009073 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 1114970009074 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 1114970009075 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1114970009076 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970009077 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970009078 substrate binding pocket [chemical binding]; other site 1114970009079 membrane-bound complex binding site; other site 1114970009080 hinge residues; other site 1114970009081 Cytochrome c; Region: Cytochrom_C; cl11414 1114970009082 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1114970009083 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1114970009084 dimer interface [polypeptide binding]; other site 1114970009085 Trp docking motif [polypeptide binding]; other site 1114970009086 active site 1114970009087 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1114970009088 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1114970009089 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1114970009090 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1114970009091 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1114970009092 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970009093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009094 active site 1114970009095 phosphorylation site [posttranslational modification] 1114970009096 intermolecular recognition site; other site 1114970009097 dimerization interface [polypeptide binding]; other site 1114970009098 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970009099 DNA binding residues [nucleotide binding] 1114970009100 dimerization interface [polypeptide binding]; other site 1114970009101 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970009102 Histidine kinase; Region: HisKA_3; pfam07730 1114970009103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009104 ATP binding site [chemical binding]; other site 1114970009105 Mg2+ binding site [ion binding]; other site 1114970009106 G-X-G motif; other site 1114970009107 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1114970009108 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1114970009109 ligand binding site [chemical binding]; other site 1114970009110 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1114970009111 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1114970009112 structural tetrad; other site 1114970009113 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114970009114 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1114970009115 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970009116 Walker A/P-loop; other site 1114970009117 ATP binding site [chemical binding]; other site 1114970009118 Q-loop/lid; other site 1114970009119 ABC transporter signature motif; other site 1114970009120 Walker B; other site 1114970009121 D-loop; other site 1114970009122 H-loop/switch region; other site 1114970009123 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114970009124 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114970009125 active site residue [active] 1114970009126 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970009127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009128 active site 1114970009129 phosphorylation site [posttranslational modification] 1114970009130 intermolecular recognition site; other site 1114970009131 dimerization interface [polypeptide binding]; other site 1114970009132 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970009133 DNA binding residues [nucleotide binding] 1114970009134 dimerization interface [polypeptide binding]; other site 1114970009135 PAS fold; Region: PAS_7; pfam12860 1114970009136 PAS fold; Region: PAS_7; pfam12860 1114970009137 PAS domain S-box; Region: sensory_box; TIGR00229 1114970009138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009139 putative active site [active] 1114970009140 heme pocket [chemical binding]; other site 1114970009141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970009142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009143 dimer interface [polypeptide binding]; other site 1114970009144 phosphorylation site [posttranslational modification] 1114970009145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009146 ATP binding site [chemical binding]; other site 1114970009147 Mg2+ binding site [ion binding]; other site 1114970009148 G-X-G motif; other site 1114970009149 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970009150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009151 active site 1114970009152 phosphorylation site [posttranslational modification] 1114970009153 intermolecular recognition site; other site 1114970009154 dimerization interface [polypeptide binding]; other site 1114970009155 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1114970009156 FIST N domain; Region: FIST; cl10701 1114970009157 FIST C domain; Region: FIST_C; pfam10442 1114970009158 NosL; Region: NosL; cl01769 1114970009159 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114970009160 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114970009161 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1114970009162 Walker A/P-loop; other site 1114970009163 ATP binding site [chemical binding]; other site 1114970009164 Q-loop/lid; other site 1114970009165 ABC transporter signature motif; other site 1114970009166 Walker B; other site 1114970009167 D-loop; other site 1114970009168 H-loop/switch region; other site 1114970009169 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1114970009170 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1114970009171 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1114970009172 nitrous-oxide reductase; Validated; Region: PRK02888 1114970009173 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114970009174 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 1114970009175 FMN-binding domain; Region: FMN_bind; cl01081 1114970009176 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1114970009177 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1114970009178 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1114970009179 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1114970009180 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970009181 Walker A/P-loop; other site 1114970009182 ATP binding site [chemical binding]; other site 1114970009183 Q-loop/lid; other site 1114970009184 ABC transporter signature motif; other site 1114970009185 Walker B; other site 1114970009186 D-loop; other site 1114970009187 H-loop/switch region; other site 1114970009188 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1114970009189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970009190 FeS/SAM binding site; other site 1114970009191 HemN C-terminal domain; Region: HemN_C; pfam06969 1114970009192 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1114970009193 HemN C-terminal domain; Region: HemN_C; pfam06969 1114970009194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 1114970009195 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1114970009196 Right handed beta helix region; Region: Beta_helix; pfam13229 1114970009197 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970009198 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970009199 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1114970009200 Cadherin repeat-like domain; Region: CA_like; cl15786 1114970009201 Ca2+ binding site [ion binding]; other site 1114970009202 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970009203 Cadherin repeat-like domain; Region: CA_like; cl15786 1114970009204 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1114970009205 Ca2+ binding site [ion binding]; other site 1114970009206 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970009207 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970009208 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1114970009209 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1114970009210 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970009211 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970009212 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 1114970009213 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114970009214 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 1114970009215 Walker A/P-loop; other site 1114970009216 ATP binding site [chemical binding]; other site 1114970009217 Q-loop/lid; other site 1114970009218 ABC transporter signature motif; other site 1114970009219 Walker B; other site 1114970009220 D-loop; other site 1114970009221 H-loop/switch region; other site 1114970009222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970009223 Helix-turn-helix domains; Region: HTH; cl00088 1114970009224 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1114970009225 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970009226 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1114970009227 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114970009228 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970009229 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1114970009230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009231 active site 1114970009232 phosphorylation site [posttranslational modification] 1114970009233 intermolecular recognition site; other site 1114970009234 dimerization interface [polypeptide binding]; other site 1114970009235 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970009236 DNA binding residues [nucleotide binding] 1114970009237 dimerization interface [polypeptide binding]; other site 1114970009238 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 1114970009239 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970009240 active site 1114970009241 ATP binding site [chemical binding]; other site 1114970009242 substrate binding site [chemical binding]; other site 1114970009243 activation loop (A-loop); other site 1114970009244 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970009245 Predicted ATPase [General function prediction only]; Region: COG3899 1114970009246 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1114970009247 GAF domain; Region: GAF; cl15785 1114970009248 PAS domain S-box; Region: sensory_box; TIGR00229 1114970009249 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009250 putative active site [active] 1114970009251 heme pocket [chemical binding]; other site 1114970009252 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1114970009253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009254 ATP binding site [chemical binding]; other site 1114970009255 Mg2+ binding site [ion binding]; other site 1114970009256 G-X-G motif; other site 1114970009257 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970009258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009259 active site 1114970009260 phosphorylation site [posttranslational modification] 1114970009261 intermolecular recognition site; other site 1114970009262 dimerization interface [polypeptide binding]; other site 1114970009263 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970009264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970009265 putative substrate translocation pore; other site 1114970009266 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1114970009267 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970009268 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970009269 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1114970009270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970009271 Walker A motif; other site 1114970009272 ATP binding site [chemical binding]; other site 1114970009273 Walker B motif; other site 1114970009274 arginine finger; other site 1114970009275 Helix-turn-helix domains; Region: HTH; cl00088 1114970009276 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1114970009277 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 1114970009278 Walker A/P-loop; other site 1114970009279 ATP binding site [chemical binding]; other site 1114970009280 Q-loop/lid; other site 1114970009281 ABC transporter signature motif; other site 1114970009282 Walker B; other site 1114970009283 D-loop; other site 1114970009284 H-loop/switch region; other site 1114970009285 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1114970009286 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1114970009287 putative ligand binding site [chemical binding]; other site 1114970009288 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1114970009289 TM-ABC transporter signature motif; other site 1114970009290 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1114970009291 TM-ABC transporter signature motif; other site 1114970009292 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1114970009293 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 1114970009294 Walker A/P-loop; other site 1114970009295 ATP binding site [chemical binding]; other site 1114970009296 Q-loop/lid; other site 1114970009297 ABC transporter signature motif; other site 1114970009298 Walker B; other site 1114970009299 D-loop; other site 1114970009300 H-loop/switch region; other site 1114970009301 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1114970009302 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970009303 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1114970009304 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1114970009305 active site 1114970009306 dimer interface [polypeptide binding]; other site 1114970009307 non-prolyl cis peptide bond; other site 1114970009308 insertion regions; other site 1114970009309 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970009310 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1114970009311 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1114970009312 Flavin binding site [chemical binding]; other site 1114970009313 Possible frameshift 1114970009314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114970009315 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970009316 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1114970009317 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1114970009318 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114970009319 HSP70 interaction site [polypeptide binding]; other site 1114970009320 Hsp70 protein; Region: HSP70; pfam00012 1114970009321 NAD-dependent deacetylase; Provisional; Region: PRK00481 1114970009322 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1114970009323 NAD+ binding site [chemical binding]; other site 1114970009324 substrate binding site [chemical binding]; other site 1114970009325 Zn binding site [ion binding]; other site 1114970009326 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 1114970009327 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 1114970009328 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 1114970009329 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1114970009330 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1114970009331 [4Fe-4S] binding site [ion binding]; other site 1114970009332 molybdopterin cofactor binding site; other site 1114970009333 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1114970009334 molybdopterin cofactor binding site; other site 1114970009335 NapD protein; Region: NapD; cl01163 1114970009336 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 1114970009337 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1114970009338 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1114970009339 hydrophobic ligand binding site; other site 1114970009340 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114970009341 active site 1114970009342 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1114970009343 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1114970009344 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970009345 hypothetical protein; Provisional; Region: PRK06184 1114970009346 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970009347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009348 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114970009349 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114970009350 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970009351 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1114970009352 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1114970009353 putative NADP binding site [chemical binding]; other site 1114970009354 putative substrate binding site [chemical binding]; other site 1114970009355 active site 1114970009356 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970009357 Helix-turn-helix domains; Region: HTH; cl00088 1114970009358 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970009359 Helix-turn-helix domains; Region: HTH; cl00088 1114970009360 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1114970009361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970009362 Coenzyme A binding pocket [chemical binding]; other site 1114970009363 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 1114970009364 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114970009365 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 1114970009366 Walker A/P-loop; other site 1114970009367 ATP binding site [chemical binding]; other site 1114970009368 Q-loop/lid; other site 1114970009369 ABC transporter signature motif; other site 1114970009370 Walker B; other site 1114970009371 D-loop; other site 1114970009372 H-loop/switch region; other site 1114970009373 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1114970009374 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114970009375 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 1114970009376 active site 1114970009377 metal binding site [ion binding]; metal-binding site 1114970009378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970009379 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970009380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970009381 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1114970009382 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1114970009383 tetramer interface [polypeptide binding]; other site 1114970009384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970009385 catalytic residue [active] 1114970009386 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1114970009387 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114970009388 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1114970009389 putative NAD(P) binding site [chemical binding]; other site 1114970009390 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970009391 glutathionine S-transferase; Provisional; Region: PRK10542 1114970009392 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1114970009393 C-terminal domain interface [polypeptide binding]; other site 1114970009394 GSH binding site (G-site) [chemical binding]; other site 1114970009395 dimer interface [polypeptide binding]; other site 1114970009396 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1114970009397 dimer interface [polypeptide binding]; other site 1114970009398 N-terminal domain interface [polypeptide binding]; other site 1114970009399 substrate binding pocket (H-site) [chemical binding]; other site 1114970009400 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970009401 Helix-turn-helix domains; Region: HTH; cl00088 1114970009402 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970009403 dimerization interface [polypeptide binding]; other site 1114970009404 substrate binding pocket [chemical binding]; other site 1114970009405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009406 PAS domain; Region: PAS_9; pfam13426 1114970009407 putative active site [active] 1114970009408 heme pocket [chemical binding]; other site 1114970009409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009410 PAS domain; Region: PAS_9; pfam13426 1114970009411 putative active site [active] 1114970009412 heme pocket [chemical binding]; other site 1114970009413 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970009414 dimer interface [polypeptide binding]; other site 1114970009415 putative CheW interface [polypeptide binding]; other site 1114970009416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114970009417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009418 dimer interface [polypeptide binding]; other site 1114970009419 phosphorylation site [posttranslational modification] 1114970009420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009421 ATP binding site [chemical binding]; other site 1114970009422 Mg2+ binding site [ion binding]; other site 1114970009423 G-X-G motif; other site 1114970009424 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970009425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009426 active site 1114970009427 phosphorylation site [posttranslational modification] 1114970009428 intermolecular recognition site; other site 1114970009429 dimerization interface [polypeptide binding]; other site 1114970009430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1114970009431 active site 1114970009432 phosphorylation site [posttranslational modification] 1114970009433 intermolecular recognition site; other site 1114970009434 dimerization interface [polypeptide binding]; other site 1114970009435 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970009436 DNA binding residues [nucleotide binding] 1114970009437 dimerization interface [polypeptide binding]; other site 1114970009438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114970009439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009440 dimer interface [polypeptide binding]; other site 1114970009441 phosphorylation site [posttranslational modification] 1114970009442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009443 ATP binding site [chemical binding]; other site 1114970009444 Mg2+ binding site [ion binding]; other site 1114970009445 G-X-G motif; other site 1114970009446 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970009447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009448 active site 1114970009449 phosphorylation site [posttranslational modification] 1114970009450 intermolecular recognition site; other site 1114970009451 dimerization interface [polypeptide binding]; other site 1114970009452 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1114970009453 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1114970009454 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1114970009455 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1114970009456 FAD binding pocket [chemical binding]; other site 1114970009457 FAD binding motif [chemical binding]; other site 1114970009458 phosphate binding motif [ion binding]; other site 1114970009459 beta-alpha-beta structure motif; other site 1114970009460 NAD binding pocket [chemical binding]; other site 1114970009461 Heme binding pocket [chemical binding]; other site 1114970009462 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970009463 catalytic loop [active] 1114970009464 iron binding site [ion binding]; other site 1114970009465 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970009466 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1114970009467 putative C-terminal domain interface [polypeptide binding]; other site 1114970009468 putative GSH binding site (G-site) [chemical binding]; other site 1114970009469 putative dimer interface [polypeptide binding]; other site 1114970009470 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1114970009471 putative N-terminal domain interface [polypeptide binding]; other site 1114970009472 putative dimer interface [polypeptide binding]; other site 1114970009473 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970009474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009475 Helix-turn-helix domains; Region: HTH; cl00088 1114970009476 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1114970009477 putative effector binding pocket; other site 1114970009478 putative dimerization interface [polypeptide binding]; other site 1114970009479 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009480 Helix-turn-helix domains; Region: HTH; cl00088 1114970009481 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970009482 dimerization interface [polypeptide binding]; other site 1114970009483 Cupin domain; Region: Cupin_2; cl09118 1114970009484 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970009485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970009486 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970009487 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1114970009488 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970009489 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1114970009490 EamA-like transporter family; Region: EamA; cl01037 1114970009491 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009492 Helix-turn-helix domains; Region: HTH; cl00088 1114970009493 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970009494 dimerization interface [polypeptide binding]; other site 1114970009495 amidase; Validated; Region: PRK06565 1114970009496 Amidase; Region: Amidase; cl11426 1114970009497 Thermostable hemolysin; Region: T_hemolysin; pfam12261 1114970009498 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114970009499 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970009500 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1114970009501 heme binding pocket [chemical binding]; other site 1114970009502 heme ligand [chemical binding]; other site 1114970009503 short chain dehydrogenase; Provisional; Region: PRK09072 1114970009504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009505 NAD(P) binding site [chemical binding]; other site 1114970009506 active site 1114970009507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970009508 TPR motif; other site 1114970009509 binding surface 1114970009510 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1114970009511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009512 active site 1114970009513 phosphorylation site [posttranslational modification] 1114970009514 intermolecular recognition site; other site 1114970009515 dimerization interface [polypeptide binding]; other site 1114970009516 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970009517 DNA binding site [nucleotide binding] 1114970009518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970009519 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970009520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009521 dimer interface [polypeptide binding]; other site 1114970009522 phosphorylation site [posttranslational modification] 1114970009523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009524 ATP binding site [chemical binding]; other site 1114970009525 Mg2+ binding site [ion binding]; other site 1114970009526 G-X-G motif; other site 1114970009527 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1114970009528 Predicted transporter component [General function prediction only]; Region: COG2391 1114970009529 Sulphur transport; Region: Sulf_transp; cl01018 1114970009530 Predicted transporter component [General function prediction only]; Region: COG2391 1114970009531 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 1114970009532 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1114970009533 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1114970009534 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1114970009535 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970009536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970009537 PAS fold; Region: PAS_4; pfam08448 1114970009538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970009539 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114970009540 Walker A motif; other site 1114970009541 ATP binding site [chemical binding]; other site 1114970009542 Walker B motif; other site 1114970009543 arginine finger; other site 1114970009544 Helix-turn-helix domains; Region: HTH; cl00088 1114970009545 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1114970009546 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1114970009547 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1114970009548 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1114970009549 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1114970009550 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451 1114970009551 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1114970009552 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1114970009553 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114970009554 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1114970009555 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114970009556 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1114970009557 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970009558 Ligand Binding Site [chemical binding]; other site 1114970009559 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970009560 Ligand Binding Site [chemical binding]; other site 1114970009561 Predicted membrane protein [Function unknown]; Region: COG3174 1114970009562 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1114970009563 universal stress protein UspE; Provisional; Region: PRK11175 1114970009564 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970009565 Ligand Binding Site [chemical binding]; other site 1114970009566 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970009567 Ligand Binding Site [chemical binding]; other site 1114970009568 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970009569 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970009570 Ligand Binding Site [chemical binding]; other site 1114970009571 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970009572 Ligand Binding Site [chemical binding]; other site 1114970009573 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114970009574 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1114970009575 putative NAD(P) binding site [chemical binding]; other site 1114970009576 putative substrate binding site [chemical binding]; other site 1114970009577 catalytic Zn binding site [ion binding]; other site 1114970009578 structural Zn binding site [ion binding]; other site 1114970009579 putative phosphoketolase; Provisional; Region: PRK05261 1114970009580 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1114970009581 TPP-binding site; other site 1114970009582 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 1114970009583 XFP C-terminal domain; Region: XFP_C; pfam09363 1114970009584 universal stress protein UspE; Provisional; Region: PRK11175 1114970009585 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970009586 Ligand Binding Site [chemical binding]; other site 1114970009587 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970009588 Ligand Binding Site [chemical binding]; other site 1114970009589 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1114970009590 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970009591 Beta-Casp domain; Region: Beta-Casp; cl12567 1114970009592 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1114970009593 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1114970009594 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970009595 ligand binding site [chemical binding]; other site 1114970009596 flexible hinge region; other site 1114970009597 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1114970009598 putative switch regulator; other site 1114970009599 non-specific DNA interactions [nucleotide binding]; other site 1114970009600 DNA binding site [nucleotide binding] 1114970009601 sequence specific DNA binding site [nucleotide binding]; other site 1114970009602 putative cAMP binding site [chemical binding]; other site 1114970009603 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1114970009604 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970009605 Helix-turn-helix domains; Region: HTH; cl00088 1114970009606 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970009607 dimerization interface [polypeptide binding]; other site 1114970009608 substrate binding pocket [chemical binding]; other site 1114970009609 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970009610 ApbE family; Region: ApbE; cl00643 1114970009611 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1114970009612 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1114970009613 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970009614 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 1114970009615 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 1114970009616 FAD binding pocket [chemical binding]; other site 1114970009617 FAD binding motif [chemical binding]; other site 1114970009618 catalytic residues [active] 1114970009619 NAD binding pocket [chemical binding]; other site 1114970009620 phosphate binding motif [ion binding]; other site 1114970009621 beta-alpha-beta structure motif; other site 1114970009622 FlgD Ig-like domain; Region: FlgD_ig; cl15790 1114970009623 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1114970009624 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970009625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009626 active site 1114970009627 phosphorylation site [posttranslational modification] 1114970009628 intermolecular recognition site; other site 1114970009629 dimerization interface [polypeptide binding]; other site 1114970009630 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970009631 DNA binding site [nucleotide binding] 1114970009632 sensor protein QseC; Provisional; Region: PRK10337 1114970009633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009634 dimer interface [polypeptide binding]; other site 1114970009635 phosphorylation site [posttranslational modification] 1114970009636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009637 ATP binding site [chemical binding]; other site 1114970009638 Mg2+ binding site [ion binding]; other site 1114970009639 G-X-G motif; other site 1114970009640 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114970009641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970009642 DNA-binding site [nucleotide binding]; DNA binding site 1114970009643 UTRA domain; Region: UTRA; cl01230 1114970009644 benzoate transport; Region: 2A0115; TIGR00895 1114970009645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970009646 putative substrate translocation pore; other site 1114970009647 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1114970009648 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114970009649 active site 1114970009650 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1114970009651 active site 1114970009652 catalytic residues [active] 1114970009653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970009654 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970009655 putative active site [active] 1114970009656 heme pocket [chemical binding]; other site 1114970009657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009658 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970009659 putative active site [active] 1114970009660 heme pocket [chemical binding]; other site 1114970009661 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009662 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970009663 putative active site [active] 1114970009664 heme pocket [chemical binding]; other site 1114970009665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970009666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114970009667 Histidine kinase; Region: HisKA_2; cl06527 1114970009668 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970009669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009670 active site 1114970009671 phosphorylation site [posttranslational modification] 1114970009672 intermolecular recognition site; other site 1114970009673 dimerization interface [polypeptide binding]; other site 1114970009674 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1114970009675 HIT family signature motif; other site 1114970009676 catalytic residue [active] 1114970009677 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 1114970009678 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009679 Helix-turn-helix domains; Region: HTH; cl00088 1114970009680 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1114970009681 putative effector binding pocket; other site 1114970009682 putative dimerization interface [polypeptide binding]; other site 1114970009683 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1114970009684 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970009685 Cupin domain; Region: Cupin_2; cl09118 1114970009686 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1114970009687 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970009688 active site 1114970009689 catalytic tetrad [active] 1114970009690 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970009691 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1114970009692 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970009693 active site 1114970009694 catalytic tetrad [active] 1114970009695 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114970009696 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114970009697 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970009698 Walker A/P-loop; other site 1114970009699 ATP binding site [chemical binding]; other site 1114970009700 Q-loop/lid; other site 1114970009701 ABC transporter signature motif; other site 1114970009702 Walker B; other site 1114970009703 D-loop; other site 1114970009704 H-loop/switch region; other site 1114970009705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009706 Helix-turn-helix domains; Region: HTH; cl00088 1114970009707 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970009708 dimerization interface [polypeptide binding]; other site 1114970009709 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 1114970009710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009711 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970009712 DNA binding residues [nucleotide binding] 1114970009713 dimerization interface [polypeptide binding]; other site 1114970009714 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1114970009715 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970009716 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1114970009717 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970009718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970009719 putative acetyltransferase; Provisional; Region: PRK03624 1114970009720 Coenzyme A binding pocket [chemical binding]; other site 1114970009721 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009722 Helix-turn-helix domains; Region: HTH; cl00088 1114970009723 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970009724 putative effector binding pocket; other site 1114970009725 dimerization interface [polypeptide binding]; other site 1114970009726 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970009727 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1114970009728 catalytic triad [active] 1114970009729 dimer interface [polypeptide binding]; other site 1114970009730 conserved cis-peptide bond; other site 1114970009731 Helix-turn-helix domains; Region: HTH; cl00088 1114970009732 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970009733 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1114970009734 Helix-turn-helix domains; Region: HTH; cl00088 1114970009735 Integrase core domain; Region: rve_3; cl15866 1114970009736 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 1114970009737 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970009738 N-terminal plug; other site 1114970009739 ligand-binding site [chemical binding]; other site 1114970009740 fec operon regulator FecR; Reviewed; Region: PRK09774 1114970009741 FecR protein; Region: FecR; pfam04773 1114970009742 RNA polymerase sigma factor; Reviewed; Region: PRK12523 1114970009743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970009744 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1114970009745 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114970009746 protein binding site [polypeptide binding]; other site 1114970009747 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1114970009748 active site 1114970009749 catalytic residues [active] 1114970009750 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1114970009751 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1114970009752 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970009753 Cyclophilin-like; Region: Cyclophil_like; cl00950 1114970009754 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009755 Helix-turn-helix domains; Region: HTH; cl00088 1114970009756 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1114970009757 putative effector binding pocket; other site 1114970009758 putative dimerization interface [polypeptide binding]; other site 1114970009759 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970009760 RHS Repeat; Region: RHS_repeat; cl11982 1114970009761 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970009762 RHS Repeat; Region: RHS_repeat; cl11982 1114970009763 RHS Repeat; Region: RHS_repeat; cl11982 1114970009764 RHS Repeat; Region: RHS_repeat; cl11982 1114970009765 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970009766 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970009767 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1114970009768 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 1114970009769 putative dimer interface [polypeptide binding]; other site 1114970009770 [2Fe-2S] cluster binding site [ion binding]; other site 1114970009771 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 1114970009772 putative dimer interface [polypeptide binding]; other site 1114970009773 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1114970009774 SLBB domain; Region: SLBB; pfam10531 1114970009775 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 1114970009776 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1114970009777 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970009778 catalytic loop [active] 1114970009779 iron binding site [ion binding]; other site 1114970009780 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 1114970009781 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1114970009782 [4Fe-4S] binding site [ion binding]; other site 1114970009783 molybdopterin cofactor binding site; other site 1114970009784 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1114970009785 molybdopterin cofactor binding site; other site 1114970009786 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 1114970009787 Inclusion body protein; Region: PixA; pfam12306 1114970009788 Chorismate mutase type II; Region: CM_2; cl00693 1114970009789 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1114970009790 catalytic triad [active] 1114970009791 conserved cis-peptide bond; other site 1114970009792 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970009793 Helix-turn-helix domains; Region: HTH; cl00088 1114970009794 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970009795 dimerization interface [polypeptide binding]; other site 1114970009796 substrate binding pocket [chemical binding]; other site 1114970009797 LysE type translocator; Region: LysE; cl00565 1114970009798 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1114970009799 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114970009800 TM-ABC transporter signature motif; other site 1114970009801 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1114970009802 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 1114970009803 Walker A/P-loop; other site 1114970009804 ATP binding site [chemical binding]; other site 1114970009805 Q-loop/lid; other site 1114970009806 ABC transporter signature motif; other site 1114970009807 Walker B; other site 1114970009808 D-loop; other site 1114970009809 H-loop/switch region; other site 1114970009810 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1114970009811 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1114970009812 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 1114970009813 putative ligand binding site [chemical binding]; other site 1114970009814 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 1114970009815 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1114970009816 putative dimerization interface [polypeptide binding]; other site 1114970009817 putative ligand binding site [chemical binding]; other site 1114970009818 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970009819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970009820 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009821 Helix-turn-helix domains; Region: HTH; cl00088 1114970009822 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1114970009823 putative effector binding pocket; other site 1114970009824 putative dimerization interface [polypeptide binding]; other site 1114970009825 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1114970009826 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970009827 active site 1114970009828 catalytic tetrad [active] 1114970009829 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114970009830 Helix-turn-helix domains; Region: HTH; cl00088 1114970009831 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114970009832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009833 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1114970009834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970009835 CAAX protease self-immunity; Region: Abi; cl00558 1114970009836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970009837 hypothetical protein; Provisional; Region: PRK08317 1114970009838 Possible frameshift 1114970009839 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1114970009840 short chain dehydrogenase; Provisional; Region: PRK06123 1114970009841 classical (c) SDRs; Region: SDR_c; cd05233 1114970009842 NAD(P) binding site [chemical binding]; other site 1114970009843 active site 1114970009844 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970009845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970009846 DNA-binding site [nucleotide binding]; DNA binding site 1114970009847 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970009848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970009849 homodimer interface [polypeptide binding]; other site 1114970009850 catalytic residue [active] 1114970009851 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1114970009852 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1114970009853 Protein of unknown function (DUF3203); Region: DUF3203; pfam11462 1114970009854 MgtC family; Region: MgtC; pfam02308 1114970009855 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1114970009856 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1114970009857 active site 1114970009858 homodimer interface [polypeptide binding]; other site 1114970009859 catalytic site [active] 1114970009860 acceptor binding site [chemical binding]; other site 1114970009861 trehalose synthase; Region: treS_nterm; TIGR02456 1114970009862 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1114970009863 active site 1114970009864 catalytic site [active] 1114970009865 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 1114970009866 glycogen branching enzyme; Provisional; Region: PRK05402 1114970009867 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1114970009868 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1114970009869 active site 1114970009870 catalytic site [active] 1114970009871 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1114970009872 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1114970009873 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1114970009874 active site 1114970009875 tetramer interface [polypeptide binding]; other site 1114970009876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970009877 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970009878 putative substrate translocation pore; other site 1114970009879 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970009880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970009881 DNA-binding site [nucleotide binding]; DNA binding site 1114970009882 FCD domain; Region: FCD; cl11656 1114970009883 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 1114970009884 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970009885 dimer interface [polypeptide binding]; other site 1114970009886 active site 1114970009887 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114970009888 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114970009889 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009890 Helix-turn-helix domains; Region: HTH; cl00088 1114970009891 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1114970009892 putative dimerization interface [polypeptide binding]; other site 1114970009893 NAD-dependent deacetylase; Provisional; Region: PRK05333 1114970009894 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1114970009895 NAD+ binding site [chemical binding]; other site 1114970009896 substrate binding site [chemical binding]; other site 1114970009897 Zn binding site [ion binding]; other site 1114970009898 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1114970009899 Glutaminase; Region: Glutaminase; cl00907 1114970009900 DNA topoisomerase III; Provisional; Region: PRK07726 1114970009901 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1114970009902 active site 1114970009903 putative interdomain interaction site [polypeptide binding]; other site 1114970009904 putative metal-binding site [ion binding]; other site 1114970009905 putative nucleotide binding site [chemical binding]; other site 1114970009906 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1114970009907 domain I; other site 1114970009908 DNA binding groove [nucleotide binding] 1114970009909 phosphate binding site [ion binding]; other site 1114970009910 domain II; other site 1114970009911 domain III; other site 1114970009912 nucleotide binding site [chemical binding]; other site 1114970009913 catalytic site [active] 1114970009914 domain IV; other site 1114970009915 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970009916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009917 active site 1114970009918 phosphorylation site [posttranslational modification] 1114970009919 intermolecular recognition site; other site 1114970009920 dimerization interface [polypeptide binding]; other site 1114970009921 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1114970009922 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970009923 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970009924 DNA binding residues [nucleotide binding] 1114970009925 fec operon regulator FecR; Reviewed; Region: PRK09774 1114970009926 FecR protein; Region: FecR; pfam04773 1114970009927 Secretin and TonB N terminus short domain; Region: STN; cl06624 1114970009928 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1114970009929 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970009930 N-terminal plug; other site 1114970009931 ligand-binding site [chemical binding]; other site 1114970009932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970009933 putative substrate translocation pore; other site 1114970009934 metabolite-proton symporter; Region: 2A0106; TIGR00883 1114970009935 choline dehydrogenase; Validated; Region: PRK02106 1114970009936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009937 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970009938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009939 Helix-turn-helix domains; Region: HTH; cl00088 1114970009940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970009941 dimerization interface [polypeptide binding]; other site 1114970009942 Cytochrome c; Region: Cytochrom_C; cl11414 1114970009943 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1114970009944 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970009945 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 1114970009946 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1114970009947 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970009948 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970009949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970009950 LexA repressor; Provisional; Region: PRK12423 1114970009951 Helix-turn-helix domains; Region: HTH; cl00088 1114970009952 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970009953 Catalytic site [active] 1114970009954 Cell division inhibitor SulA; Region: SulA; cl01880 1114970009955 DNA Polymerase Y-family; Region: PolY_like; cd03468 1114970009956 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1114970009957 active site 1114970009958 DNA binding site [nucleotide binding] 1114970009959 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1114970009960 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1114970009961 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1114970009962 generic binding surface I; other site 1114970009963 generic binding surface II; other site 1114970009964 putative diguanylate cyclase; Provisional; Region: PRK09776 1114970009965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009966 putative active site [active] 1114970009967 heme pocket [chemical binding]; other site 1114970009968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970009969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009970 dimer interface [polypeptide binding]; other site 1114970009971 phosphorylation site [posttranslational modification] 1114970009972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009973 ATP binding site [chemical binding]; other site 1114970009974 G-X-G motif; other site 1114970009975 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970009976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009977 active site 1114970009978 phosphorylation site [posttranslational modification] 1114970009979 intermolecular recognition site; other site 1114970009980 dimerization interface [polypeptide binding]; other site 1114970009981 Domain of unknown function (DUF305); Region: DUF305; cl15795 1114970009982 Protein of unknown function (DUF465); Region: DUF465; cl01070 1114970009983 transcriptional regulator HdfR; Provisional; Region: PRK03601 1114970009984 Helix-turn-helix domains; Region: HTH; cl00088 1114970009985 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970009986 SCP-2 sterol transfer family; Region: SCP2; cl01225 1114970009987 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114970009988 catalytic core [active] 1114970009989 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1114970009990 putative inner membrane peptidase; Provisional; Region: PRK11778 1114970009991 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1114970009992 tandem repeat interface [polypeptide binding]; other site 1114970009993 oligomer interface [polypeptide binding]; other site 1114970009994 active site residues [active] 1114970009995 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 1114970009996 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1114970009997 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114970009998 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114970009999 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324 1114970010000 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1114970010001 putative ligand binding site [chemical binding]; other site 1114970010002 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1114970010003 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1114970010004 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1114970010005 substrate binding pocket [chemical binding]; other site 1114970010006 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1114970010007 B12 binding site [chemical binding]; other site 1114970010008 cobalt ligand [ion binding]; other site 1114970010009 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1114970010010 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 1114970010011 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1114970010012 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 1114970010013 NifU-like domain; Region: NifU; cl00484 1114970010014 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1114970010015 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1114970010016 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 1114970010017 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1114970010018 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 1114970010019 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1114970010020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970010021 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1114970010022 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1114970010023 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1114970010024 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1114970010025 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1114970010026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970010027 Walker A motif; other site 1114970010028 ATP binding site [chemical binding]; other site 1114970010029 Walker B motif; other site 1114970010030 arginine finger; other site 1114970010031 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114970010032 metal ion-dependent adhesion site (MIDAS); other site 1114970010033 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 1114970010034 PLD-like domain; Region: PLDc_2; pfam13091 1114970010035 putative active site [active] 1114970010036 catalytic site [active] 1114970010037 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 1114970010038 PLD-like domain; Region: PLDc_2; pfam13091 1114970010039 putative active site [active] 1114970010040 catalytic site [active] 1114970010041 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 1114970010042 hypothetical protein; Provisional; Region: PRK10040 1114970010043 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970010044 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970010045 substrate binding pocket [chemical binding]; other site 1114970010046 membrane-bound complex binding site; other site 1114970010047 hinge residues; other site 1114970010048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970010049 dimer interface [polypeptide binding]; other site 1114970010050 conserved gate region; other site 1114970010051 putative PBP binding loops; other site 1114970010052 ABC-ATPase subunit interface; other site 1114970010053 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970010054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970010055 dimer interface [polypeptide binding]; other site 1114970010056 conserved gate region; other site 1114970010057 putative PBP binding loops; other site 1114970010058 ABC-ATPase subunit interface; other site 1114970010059 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970010060 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970010061 Walker A/P-loop; other site 1114970010062 ATP binding site [chemical binding]; other site 1114970010063 Q-loop/lid; other site 1114970010064 ABC transporter signature motif; other site 1114970010065 Walker B; other site 1114970010066 D-loop; other site 1114970010067 H-loop/switch region; other site 1114970010068 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114970010069 homotrimer interaction site [polypeptide binding]; other site 1114970010070 putative active site [active] 1114970010071 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970010072 Helix-turn-helix domains; Region: HTH; cl00088 1114970010073 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970010074 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1114970010075 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1114970010076 dimer interface [polypeptide binding]; other site 1114970010077 active site 1114970010078 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970010079 substrate binding site [chemical binding]; other site 1114970010080 catalytic residue [active] 1114970010081 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114970010082 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114970010083 substrate binding site [chemical binding]; other site 1114970010084 ATP binding site [chemical binding]; other site 1114970010085 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1114970010086 PAS fold; Region: PAS_4; pfam08448 1114970010087 putative diguanylate cyclase; Provisional; Region: PRK09776 1114970010088 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1114970010089 PAS fold; Region: PAS_4; pfam08448 1114970010090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970010091 putative active site [active] 1114970010092 heme pocket [chemical binding]; other site 1114970010093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970010094 dimer interface [polypeptide binding]; other site 1114970010095 phosphorylation site [posttranslational modification] 1114970010096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970010097 ATP binding site [chemical binding]; other site 1114970010098 Mg2+ binding site [ion binding]; other site 1114970010099 G-X-G motif; other site 1114970010100 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970010101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970010102 active site 1114970010103 phosphorylation site [posttranslational modification] 1114970010104 intermolecular recognition site; other site 1114970010105 dimerization interface [polypeptide binding]; other site 1114970010106 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 1114970010107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970010108 Walker A motif; other site 1114970010109 ATP binding site [chemical binding]; other site 1114970010110 Walker B motif; other site 1114970010111 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1114970010112 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1114970010113 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970010114 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970010115 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1114970010116 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1114970010117 NAD binding site [chemical binding]; other site 1114970010118 homotetramer interface [polypeptide binding]; other site 1114970010119 homodimer interface [polypeptide binding]; other site 1114970010120 substrate binding site [chemical binding]; other site 1114970010121 active site 1114970010122 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1114970010123 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1114970010124 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970010125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970010126 Walker B motif; other site 1114970010127 arginine finger; other site 1114970010128 Helix-turn-helix domains; Region: HTH; cl00088 1114970010129 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1114970010130 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114970010131 Walker A/P-loop; other site 1114970010132 ATP binding site [chemical binding]; other site 1114970010133 Q-loop/lid; other site 1114970010134 ABC transporter signature motif; other site 1114970010135 Walker B; other site 1114970010136 D-loop; other site 1114970010137 H-loop/switch region; other site 1114970010138 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970010139 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114970010140 Walker A/P-loop; other site 1114970010141 ATP binding site [chemical binding]; other site 1114970010142 Q-loop/lid; other site 1114970010143 ABC transporter signature motif; other site 1114970010144 Walker B; other site 1114970010145 D-loop; other site 1114970010146 H-loop/switch region; other site 1114970010147 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970010148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970010149 dimer interface [polypeptide binding]; other site 1114970010150 conserved gate region; other site 1114970010151 putative PBP binding loops; other site 1114970010152 ABC-ATPase subunit interface; other site 1114970010153 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1114970010154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970010155 dimer interface [polypeptide binding]; other site 1114970010156 conserved gate region; other site 1114970010157 putative PBP binding loops; other site 1114970010158 ABC-ATPase subunit interface; other site 1114970010159 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1114970010160 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1114970010161 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1114970010162 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1114970010163 NeuB family; Region: NeuB; cl00496 1114970010164 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1114970010165 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114970010166 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1114970010167 active site 1114970010168 catalytic triad [active] 1114970010169 dimer interface [polypeptide binding]; other site 1114970010170 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970010171 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970010172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970010173 active site 1114970010174 phosphorylation site [posttranslational modification] 1114970010175 intermolecular recognition site; other site 1114970010176 dimerization interface [polypeptide binding]; other site 1114970010177 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970010178 DNA binding residues [nucleotide binding] 1114970010179 dimerization interface [polypeptide binding]; other site 1114970010180 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1114970010181 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1114970010182 GIY-YIG motif/motif A; other site 1114970010183 active site 1114970010184 catalytic site [active] 1114970010185 putative DNA binding site [nucleotide binding]; other site 1114970010186 metal binding site [ion binding]; metal-binding site 1114970010187 UvrB/uvrC motif; Region: UVR; pfam02151 1114970010188 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1114970010189 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1114970010190 integrase; Provisional; Region: PRK09692 1114970010191 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1114970010192 active site 1114970010193 Int/Topo IB signature motif; other site 1114970010194 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1114970010195 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970010196 Catalytic site [active] 1114970010197 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1114970010198 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1114970010199 active site 1114970010200 DNA binding site [nucleotide binding] 1114970010201 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1114970010202 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1114970010203 Putative helicase; Region: TraI_2; pfam07514 1114970010204 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1114970010205 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1114970010206 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1114970010207 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1114970010208 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1114970010209 TraU protein; Region: TraU; cl06067 1114970010210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970010211 non-specific DNA binding site [nucleotide binding]; other site 1114970010212 salt bridge; other site 1114970010213 sequence-specific DNA binding site [nucleotide binding]; other site 1114970010214 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1114970010215 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970010216 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970010217 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1114970010218 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1114970010219 Walker A/P-loop; other site 1114970010220 ATP binding site [chemical binding]; other site 1114970010221 Q-loop/lid; other site 1114970010222 ABC transporter signature motif; other site 1114970010223 Walker B; other site 1114970010224 D-loop; other site 1114970010225 H-loop/switch region; other site 1114970010226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970010227 Walker A/P-loop; other site 1114970010228 ATP binding site [chemical binding]; other site 1114970010229 Q-loop/lid; other site 1114970010230 ABC transporter signature motif; other site 1114970010231 Walker B; other site 1114970010232 D-loop; other site 1114970010233 H-loop/switch region; other site 1114970010234 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114970010235 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114970010236 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114970010237 Acetokinase family; Region: Acetate_kinase; cl01029 1114970010238 Acetokinase family; Region: Acetate_kinase; cl01029 1114970010239 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1114970010240 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970010241 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1114970010242 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 1114970010243 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114970010244 catalytic Zn binding site [ion binding]; other site 1114970010245 structural Zn binding site [ion binding]; other site 1114970010246 NAD(P) binding site [chemical binding]; other site 1114970010247 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1114970010248 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1114970010249 transmembrane helices; other site 1114970010250 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1114970010251 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114970010252 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1114970010253 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114970010254 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1114970010255 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114970010256 IHF - DNA interface [nucleotide binding]; other site 1114970010257 IHF dimer interface [polypeptide binding]; other site 1114970010258 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1114970010259 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970010260 Walker A motif; other site 1114970010261 ATP binding site [chemical binding]; other site 1114970010262 Walker B motif; other site 1114970010263 arginine finger; other site 1114970010264 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1114970010265 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1114970010266 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 1114970010267 Protein of unknown function (DUF2895); Region: DUF2895; cl12968 1114970010268 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 1114970010269 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 1114970010270 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 1114970010271 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1114970010272 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1114970010273 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1114970010274 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 1114970010275 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970010276 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970010277 Integrase core domain; Region: rve; cl01316 1114970010278 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970010279 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970010280 Helix-turn-helix domains; Region: HTH; cl00088 1114970010281 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 1114970010282 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 1114970010283 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1114970010284 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 1114970010285 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1114970010286 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1114970010287 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1114970010288 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1114970010289 MPN+ (JAMM) motif; other site 1114970010290 Zinc-binding site [ion binding]; other site 1114970010291 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1114970010292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970010293 DNA topoisomerase III; Provisional; Region: PRK07726 1114970010294 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1114970010295 active site 1114970010296 putative interdomain interaction site [polypeptide binding]; other site 1114970010297 putative metal-binding site [ion binding]; other site 1114970010298 putative nucleotide binding site [chemical binding]; other site 1114970010299 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1114970010300 domain I; other site 1114970010301 DNA binding groove [nucleotide binding] 1114970010302 phosphate binding site [ion binding]; other site 1114970010303 domain II; other site 1114970010304 domain III; other site 1114970010305 nucleotide binding site [chemical binding]; other site 1114970010306 catalytic site [active] 1114970010307 domain IV; other site 1114970010308 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1114970010309 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1114970010310 dimer interface [polypeptide binding]; other site 1114970010311 ssDNA binding site [nucleotide binding]; other site 1114970010312 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114970010313 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 1114970010314 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 1114970010315 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1114970010316 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 1114970010317 ParB-like nuclease domain; Region: ParBc; cl02129 1114970010318 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1114970010319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970010320 Helix-turn-helix domains; Region: HTH; cl00088 1114970010321 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1114970010322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010323 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970010324 beta-ketothiolase; Provisional; Region: PRK09051 1114970010325 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970010326 dimer interface [polypeptide binding]; other site 1114970010327 active site 1114970010328 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970010329 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970010330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970010331 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970010332 dimerization interface [polypeptide binding]; other site 1114970010333 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970010334 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970010335 dimer interface [polypeptide binding]; other site 1114970010336 putative CheW interface [polypeptide binding]; other site 1114970010337 Helix-turn-helix domains; Region: HTH; cl00088 1114970010338 Helix-turn-helix domains; Region: HTH; cl00088 1114970010339 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1114970010340 homodecamer interface [polypeptide binding]; other site 1114970010341 GTP cyclohydrolase I; Provisional; Region: PLN03044 1114970010342 active site 1114970010343 putative catalytic site residues [active] 1114970010344 zinc binding site [ion binding]; other site 1114970010345 GTP-CH-I/GFRP interaction surface; other site 1114970010346 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1114970010347 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1114970010348 dimer interface [polypeptide binding]; other site 1114970010349 PYR/PP interface [polypeptide binding]; other site 1114970010350 TPP binding site [chemical binding]; other site 1114970010351 substrate binding site [chemical binding]; other site 1114970010352 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1114970010353 TPP-binding site [chemical binding]; other site 1114970010354 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1114970010355 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1114970010356 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1114970010357 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970010358 classical (c) SDRs; Region: SDR_c; cd05233 1114970010359 NAD(P) binding site [chemical binding]; other site 1114970010360 active site 1114970010361 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970010362 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1114970010363 putative active site [active] 1114970010364 ATP binding site [chemical binding]; other site 1114970010365 putative substrate binding site [chemical binding]; other site 1114970010366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010367 NAD(P) binding site [chemical binding]; other site 1114970010368 active site 1114970010369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970010370 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970010371 putative substrate translocation pore; other site 1114970010372 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114970010373 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114970010374 NAD(P) binding site [chemical binding]; other site 1114970010375 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970010376 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970010377 Helix-turn-helix domains; Region: HTH; cl00088 1114970010378 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1114970010379 putative substrate binding pocket [chemical binding]; other site 1114970010380 dimerization interface [polypeptide binding]; other site 1114970010381 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114970010382 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970010383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010384 NAD(P) binding site [chemical binding]; other site 1114970010385 active site 1114970010386 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1114970010387 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1114970010388 Ycf48-like protein; Provisional; Region: PRK13684 1114970010389 Ycf48-like protein; Provisional; Region: PRK13684 1114970010390 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1114970010391 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1114970010392 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1114970010393 active site 1114970010394 metal binding site [ion binding]; metal-binding site 1114970010395 enoyl-CoA hydratase; Provisional; Region: PRK06688 1114970010396 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970010397 substrate binding site [chemical binding]; other site 1114970010398 oxyanion hole (OAH) forming residues; other site 1114970010399 trimer interface [polypeptide binding]; other site 1114970010400 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1114970010401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010402 NAD(P) binding site [chemical binding]; other site 1114970010403 active site 1114970010404 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1114970010405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970010407 Helix-turn-helix domains; Region: HTH; cl00088 1114970010408 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1114970010409 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1114970010410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010411 NAD(P) binding site [chemical binding]; other site 1114970010412 active site 1114970010413 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1114970010414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970010415 putative substrate translocation pore; other site 1114970010416 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970010417 short chain dehydrogenase; Provisional; Region: PRK06180 1114970010418 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1114970010419 NADP binding site [chemical binding]; other site 1114970010420 active site 1114970010421 steroid binding site; other site 1114970010422 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1114970010423 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970010424 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970010425 catalytic loop [active] 1114970010426 iron binding site [ion binding]; other site 1114970010427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970010428 putative substrate translocation pore; other site 1114970010429 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970010430 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1114970010431 short chain dehydrogenase; Provisional; Region: PRK06138 1114970010432 classical (c) SDRs; Region: SDR_c; cd05233 1114970010433 NAD(P) binding site [chemical binding]; other site 1114970010434 active site 1114970010435 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1114970010436 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1114970010437 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1114970010438 active site 1114970010439 Fe binding site [ion binding]; other site 1114970010440 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970010441 Transmembrane secretion effector; Region: MFS_3; pfam05977 1114970010442 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970010443 Helix-turn-helix domains; Region: HTH; cl00088 1114970010444 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970010445 lipid-transfer protein; Provisional; Region: PRK07855 1114970010446 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1114970010447 active site 1114970010448 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1114970010449 DUF35 OB-fold domain; Region: DUF35; pfam01796 1114970010450 short chain dehydrogenase; Provisional; Region: PRK12828 1114970010451 dihydropteridine reductase (DHPR), classical (c) SDRs; Region: DHPR_SDR_c_like; cd05334 1114970010452 NAD binding site [chemical binding]; other site 1114970010453 homodimer interface [polypeptide binding]; other site 1114970010454 active site 1114970010455 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970010456 This alignment model represents the N-terminal rieske domain of the oxygenase alpha subunit (DitA) of diterpenoid dioxygenase (DTDO). DTDO is a novel aromatic-ring-hydroxylating dioxygenase found in Pseudomonas and other proteobacteria that degrades...; Region: Rieske_RO_Alpha_DTDO; cd03536 1114970010457 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1114970010458 beta subunit interface [polypeptide binding]; other site 1114970010459 alpha subunit interface [polypeptide binding]; other site 1114970010460 active site 1114970010461 substrate binding site [chemical binding]; other site 1114970010462 Fe binding site [ion binding]; other site 1114970010463 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1114970010464 inter-subunit interface; other site 1114970010465 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 1114970010466 short chain dehydrogenase; Provisional; Region: PRK12939 1114970010467 classical (c) SDRs; Region: SDR_c; cd05233 1114970010468 NAD(P) binding site [chemical binding]; other site 1114970010469 active site 1114970010470 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1114970010471 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970010472 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970010473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970010474 Helix-turn-helix domains; Region: HTH; cl00088 1114970010475 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114970010476 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970010477 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 1114970010478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010479 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970010480 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970010481 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1114970010482 dimer interface [polypeptide binding]; other site 1114970010483 active site 1114970010484 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1114970010485 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114970010486 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970010487 active site 1114970010488 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970010489 active site 1114970010490 enoyl-CoA hydratase; Provisional; Region: PRK09245 1114970010491 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970010492 substrate binding site [chemical binding]; other site 1114970010493 oxyanion hole (OAH) forming residues; other site 1114970010494 trimer interface [polypeptide binding]; other site 1114970010495 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1114970010496 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970010497 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970010498 active site 1114970010499 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1114970010500 catalytic residues [active] 1114970010501 dimer interface [polypeptide binding]; other site 1114970010502 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1114970010503 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1114970010504 active site 1114970010505 ATP-binding site [chemical binding]; other site 1114970010506 pantoate-binding site; other site 1114970010507 HXXH motif; other site 1114970010508 Cache domain; Region: Cache_2; cl07034 1114970010509 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 1114970010510 major facilitator superfamily transporter; Provisional; Region: PRK05122 1114970010511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970010512 putative substrate translocation pore; other site 1114970010513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970010514 Helix-turn-helix domains; Region: HTH; cl00088 1114970010515 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 1114970010516 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970010517 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1114970010518 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970010519 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970010520 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1114970010521 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 1114970010522 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1114970010523 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1114970010524 nitrous-oxide reductase; Validated; Region: PRK02888 1114970010525 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114970010526 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1114970010527 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114970010528 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970010529 Walker A/P-loop; other site 1114970010530 ATP binding site [chemical binding]; other site 1114970010531 Q-loop/lid; other site 1114970010532 ABC transporter signature motif; other site 1114970010533 Walker B; other site 1114970010534 D-loop; other site 1114970010535 H-loop/switch region; other site 1114970010536 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114970010537 NosL; Region: NosL; cl01769 1114970010538 Cytochrome c; Region: Cytochrom_C; cl11414 1114970010539 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1114970010540 metal ion-dependent adhesion site (MIDAS); other site 1114970010541 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970010542 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1114970010543 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1114970010544 Low-spin heme binding site [chemical binding]; other site 1114970010545 D-pathway; other site 1114970010546 Binuclear center (active site) [active] 1114970010547 K-pathway; other site 1114970010548 Putative proton exit pathway; other site 1114970010549 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 1114970010550 Cytochrome c; Region: Cytochrom_C; cl11414 1114970010551 Cytochrome c; Region: Cytochrom_C; cl11414 1114970010552 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 1114970010553 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1114970010554 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1114970010555 GAF domain; Region: GAF; cl15785 1114970010556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970010557 Walker A motif; other site 1114970010558 ATP binding site [chemical binding]; other site 1114970010559 Walker B motif; other site 1114970010560 arginine finger; other site 1114970010561 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1114970010562 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970010563 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970010564 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1114970010565 iron binding site [ion binding]; other site 1114970010566 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1114970010567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970010568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970010569 Helix-turn-helix domains; Region: HTH; cl00088 1114970010570 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970010571 putative effector binding pocket; other site 1114970010572 dimerization interface [polypeptide binding]; other site 1114970010573 Cupin domain; Region: Cupin_2; cl09118 1114970010574 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970010575 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 1114970010576 NAD(P) binding site [chemical binding]; other site 1114970010577 catalytic residues [active] 1114970010578 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1114970010579 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1114970010580 active site 1114970010581 dimer interface [polypeptide binding]; other site 1114970010582 metal binding site [ion binding]; metal-binding site 1114970010583 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1114970010584 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1114970010585 active site 1114970010586 YCII-related domain; Region: YCII; cl00999 1114970010587 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1114970010588 iron-sulfur cluster [ion binding]; other site 1114970010589 [2Fe-2S] cluster binding site [ion binding]; other site 1114970010590 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1114970010591 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970010592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970010593 putative substrate translocation pore; other site 1114970010594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010595 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970010596 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970010597 Flavin Reductases; Region: FlaRed; cl00801 1114970010598 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1114970010599 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970010600 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970010601 Helix-turn-helix domains; Region: HTH; cl00088 1114970010602 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970010603 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970010604 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970010605 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1114970010606 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1114970010607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010608 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114970010609 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1114970010610 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1114970010611 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1114970010612 putative hydrophobic ligand binding site [chemical binding]; other site 1114970010613 protein interface [polypeptide binding]; other site 1114970010614 gate; other site 1114970010615 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1114970010616 Helix-turn-helix domains; Region: HTH; cl00088 1114970010617 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970010618 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970010619 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970010620 active site 1114970010621 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970010622 active site 1114970010623 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970010624 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970010625 Dienelactone hydrolase family; Region: DLH; pfam01738 1114970010626 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970010627 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1114970010628 classical (c) SDRs; Region: SDR_c; cd05233 1114970010629 NAD(P) binding site [chemical binding]; other site 1114970010630 active site 1114970010631 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970010632 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 1114970010633 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970010634 putative active site [active] 1114970010635 putative metal binding site [ion binding]; other site 1114970010636 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 1114970010637 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1114970010638 active site 1114970010639 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1114970010640 DUF35 OB-fold domain; Region: DUF35; pfam01796 1114970010641 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1114970010642 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114970010643 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114970010644 putative transporter; Provisional; Region: PRK10504 1114970010645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970010646 putative substrate translocation pore; other site 1114970010647 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1114970010648 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970010649 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114970010650 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114970010651 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1114970010652 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 1114970010653 active site 1114970010654 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1114970010655 Helix-turn-helix domains; Region: HTH; cl00088 1114970010656 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1114970010657 putative dimerization interface [polypeptide binding]; other site 1114970010658 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1114970010659 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1114970010660 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1114970010661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1114970010662 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1114970010663 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1114970010664 Helix-turn-helix domains; Region: HTH; cl00088 1114970010665 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1114970010666 Helix-turn-helix domains; Region: HTH; cl00088 1114970010667 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1114970010668 putative dimerization interface [polypeptide binding]; other site 1114970010669 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1114970010670 Esterase/lipase [General function prediction only]; Region: COG1647 1114970010671 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970010672 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114970010673 PYR/PP interface [polypeptide binding]; other site 1114970010674 dimer interface [polypeptide binding]; other site 1114970010675 TPP binding site [chemical binding]; other site 1114970010676 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1114970010677 TPP-binding site [chemical binding]; other site 1114970010678 dimer interface [polypeptide binding]; other site 1114970010679 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1114970010680 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970010681 AAA domain; Region: AAA_33; pfam13671 1114970010682 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970010683 LysE type translocator; Region: LysE; cl00565 1114970010684 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970010685 LysE type translocator; Region: LysE; cl00565 1114970010686 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 1114970010687 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1114970010688 putative ligand binding site [chemical binding]; other site 1114970010689 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970010690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970010691 dimer interface [polypeptide binding]; other site 1114970010692 phosphorylation site [posttranslational modification] 1114970010693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970010694 ATP binding site [chemical binding]; other site 1114970010695 Mg2+ binding site [ion binding]; other site 1114970010696 G-X-G motif; other site 1114970010697 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970010698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970010699 active site 1114970010700 phosphorylation site [posttranslational modification] 1114970010701 intermolecular recognition site; other site 1114970010702 dimerization interface [polypeptide binding]; other site 1114970010703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970010704 ATP binding site [chemical binding]; other site 1114970010705 Mg2+ binding site [ion binding]; other site 1114970010706 G-X-G motif; other site 1114970010707 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1114970010708 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1114970010709 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970010710 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970010711 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1114970010712 Helix-turn-helix domains; Region: HTH; cl00088 1114970010713 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970010714 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1114970010715 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1114970010716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970010717 catalytic residue [active] 1114970010718 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 1114970010719 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1114970010720 dimer interface [polypeptide binding]; other site 1114970010721 TPP-binding site [chemical binding]; other site 1114970010722 Integrase core domain; Region: rve_3; cl15866 1114970010723 Helix-turn-helix domains; Region: HTH; cl00088 1114970010724 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1114970010725 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 1114970010726 metal binding site [ion binding]; metal-binding site 1114970010727 dimer interface [polypeptide binding]; other site 1114970010728 hypothetical protein; Provisional; Region: PRK07079 1114970010729 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 1114970010730 metal binding site [ion binding]; metal-binding site 1114970010731 putative dimer interface [polypeptide binding]; other site 1114970010732 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1114970010733 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114970010734 Walker A/P-loop; other site 1114970010735 ATP binding site [chemical binding]; other site 1114970010736 Q-loop/lid; other site 1114970010737 ABC transporter signature motif; other site 1114970010738 Walker B; other site 1114970010739 D-loop; other site 1114970010740 H-loop/switch region; other site 1114970010741 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970010742 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114970010743 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114970010744 Walker A/P-loop; other site 1114970010745 ATP binding site [chemical binding]; other site 1114970010746 Q-loop/lid; other site 1114970010747 ABC transporter signature motif; other site 1114970010748 Walker B; other site 1114970010749 D-loop; other site 1114970010750 H-loop/switch region; other site 1114970010751 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970010752 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114970010753 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114970010754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970010755 dimer interface [polypeptide binding]; other site 1114970010756 conserved gate region; other site 1114970010757 putative PBP binding loops; other site 1114970010758 ABC-ATPase subunit interface; other site 1114970010759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970010760 dimer interface [polypeptide binding]; other site 1114970010761 conserved gate region; other site 1114970010762 putative PBP binding loops; other site 1114970010763 ABC-ATPase subunit interface; other site 1114970010764 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 1114970010765 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1114970010766 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970010767 Helix-turn-helix domains; Region: HTH; cl00088 1114970010768 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970010769 dimerization interface [polypeptide binding]; other site 1114970010770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970010771 putative transporter; Provisional; Region: PRK10054 1114970010772 putative substrate translocation pore; other site 1114970010773 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1114970010774 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1114970010775 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1114970010776 active site 1114970010777 catalytic site [active] 1114970010778 Zn binding site [ion binding]; other site 1114970010779 tetramer interface [polypeptide binding]; other site 1114970010780 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1114970010781 active site 1114970010782 catalytic site [active] 1114970010783 Zn binding site [ion binding]; other site 1114970010784 tetramer interface [polypeptide binding]; other site 1114970010785 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970010786 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970010787 substrate binding pocket [chemical binding]; other site 1114970010788 membrane-bound complex binding site; other site 1114970010789 hinge residues; other site 1114970010790 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970010791 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970010792 Walker A/P-loop; other site 1114970010793 ATP binding site [chemical binding]; other site 1114970010794 Q-loop/lid; other site 1114970010795 ABC transporter signature motif; other site 1114970010796 Walker B; other site 1114970010797 D-loop; other site 1114970010798 H-loop/switch region; other site 1114970010799 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970010800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970010801 dimer interface [polypeptide binding]; other site 1114970010802 conserved gate region; other site 1114970010803 putative PBP binding loops; other site 1114970010804 ABC-ATPase subunit interface; other site 1114970010805 argininosuccinate lyase; Provisional; Region: PRK00855 1114970010806 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1114970010807 active sites [active] 1114970010808 tetramer interface [polypeptide binding]; other site 1114970010809 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970010810 Helix-turn-helix domains; Region: HTH; cl00088 1114970010811 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970010812 dimerization interface [polypeptide binding]; other site 1114970010813 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970010814 Helix-turn-helix domains; Region: HTH; cl00088 1114970010815 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970010816 dimerization interface [polypeptide binding]; other site 1114970010817 substrate binding pocket [chemical binding]; other site 1114970010818 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1114970010819 EamA-like transporter family; Region: EamA; cl01037 1114970010820 short chain dehydrogenase; Provisional; Region: PRK06123 1114970010821 classical (c) SDRs; Region: SDR_c; cd05233 1114970010822 NAD(P) binding site [chemical binding]; other site 1114970010823 active site 1114970010824 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1114970010825 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1114970010826 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1114970010827 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114970010828 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 1114970010829 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1114970010830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010831 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194 1114970010832 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1114970010833 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1114970010834 homodimer interface [polypeptide binding]; other site 1114970010835 NADP binding site [chemical binding]; other site 1114970010836 substrate binding site [chemical binding]; other site 1114970010837 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1114970010838 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1114970010839 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1114970010840 putative active site [active] 1114970010841 putative substrate binding site [chemical binding]; other site 1114970010842 putative cosubstrate binding site; other site 1114970010843 catalytic site [active] 1114970010844 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1114970010845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970010846 non-specific DNA binding site [nucleotide binding]; other site 1114970010847 salt bridge; other site 1114970010848 sequence-specific DNA binding site [nucleotide binding]; other site 1114970010849 Cupin domain; Region: Cupin_2; cl09118 1114970010850 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 1114970010851 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970010852 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1114970010853 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1114970010854 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 1114970010855 putative active site [active] 1114970010856 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 1114970010857 domain_subunit interface; other site 1114970010858 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1114970010859 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1114970010860 active site 1114970010861 FMN binding site [chemical binding]; other site 1114970010862 substrate binding site [chemical binding]; other site 1114970010863 3Fe-4S cluster binding site [ion binding]; other site 1114970010864 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1114970010865 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194 1114970010866 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1114970010867 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1114970010868 homodimer interface [polypeptide binding]; other site 1114970010869 NADP binding site [chemical binding]; other site 1114970010870 substrate binding site [chemical binding]; other site 1114970010871 Amino acid permease; Region: AA_permease_2; pfam13520 1114970010872 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1114970010873 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1114970010874 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1114970010875 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114970010876 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1114970010877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010878 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1114970010879 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1114970010880 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1114970010881 putative active site [active] 1114970010882 putative substrate binding site [chemical binding]; other site 1114970010883 putative cosubstrate binding site; other site 1114970010884 catalytic site [active] 1114970010885 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1114970010886 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114970010887 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 1114970010888 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1114970010889 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1114970010890 FMN-binding pocket [chemical binding]; other site 1114970010891 flavin binding motif; other site 1114970010892 phosphate binding motif [ion binding]; other site 1114970010893 beta-alpha-beta structure motif; other site 1114970010894 NAD binding pocket [chemical binding]; other site 1114970010895 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970010896 catalytic loop [active] 1114970010897 iron binding site [ion binding]; other site 1114970010898 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 1114970010899 Histidine kinase; Region: HisKA_3; pfam07730 1114970010900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970010901 ATP binding site [chemical binding]; other site 1114970010902 Mg2+ binding site [ion binding]; other site 1114970010903 G-X-G motif; other site 1114970010904 transcriptional regulator NarL; Provisional; Region: PRK10651 1114970010905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970010906 active site 1114970010907 phosphorylation site [posttranslational modification] 1114970010908 intermolecular recognition site; other site 1114970010909 dimerization interface [polypeptide binding]; other site 1114970010910 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970010911 DNA binding residues [nucleotide binding] 1114970010912 dimerization interface [polypeptide binding]; other site 1114970010913 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970010914 PAS domain; Region: PAS_9; pfam13426 1114970010915 PAS fold; Region: PAS_3; pfam08447 1114970010916 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1114970010917 Integral membrane protein TerC family; Region: TerC; cl10468 1114970010918 FOG: CBS domain [General function prediction only]; Region: COG0517 1114970010919 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114970010920 FOG: CBS domain [General function prediction only]; Region: COG0517 1114970010921 Transporter associated domain; Region: CorC_HlyC; cl08393 1114970010922 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 1114970010923 putative homodimer interface [polypeptide binding]; other site 1114970010924 putative homotetramer interface [polypeptide binding]; other site 1114970010925 putative metal binding site [ion binding]; other site 1114970010926 putative homodimer-homodimer interface [polypeptide binding]; other site 1114970010927 putative allosteric switch controlling residues; other site 1114970010928 High-affinity nickel-transport protein; Region: NicO; cl00964 1114970010929 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1114970010930 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1114970010931 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114970010932 Zn2+ binding site [ion binding]; other site 1114970010933 Mg2+ binding site [ion binding]; other site 1114970010934 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970010935 dimer interface [polypeptide binding]; other site 1114970010936 putative CheW interface [polypeptide binding]; other site 1114970010937 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970010938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970010939 active site 1114970010940 phosphorylation site [posttranslational modification] 1114970010941 intermolecular recognition site; other site 1114970010942 dimerization interface [polypeptide binding]; other site 1114970010943 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1114970010944 anti sigma factor interaction site; other site 1114970010945 regulatory phosphorylation site [posttranslational modification]; other site 1114970010946 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1114970010947 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970010948 putative binding surface; other site 1114970010949 active site 1114970010950 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1114970010951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970010952 ATP binding site [chemical binding]; other site 1114970010953 Mg2+ binding site [ion binding]; other site 1114970010954 G-X-G motif; other site 1114970010955 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1114970010956 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970010957 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970010958 dimer interface [polypeptide binding]; other site 1114970010959 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1114970010960 putative CheW interface [polypeptide binding]; other site 1114970010961 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1114970010962 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1114970010963 putative CheA interaction surface; other site 1114970010964 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1114970010965 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1114970010966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970010967 CheD chemotactic sensory transduction; Region: CheD; cl00810 1114970010968 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1114970010969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970010970 active site 1114970010971 phosphorylation site [posttranslational modification] 1114970010972 intermolecular recognition site; other site 1114970010973 dimerization interface [polypeptide binding]; other site 1114970010974 CheB methylesterase; Region: CheB_methylest; pfam01339 1114970010975 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970010976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970010977 active site 1114970010978 phosphorylation site [posttranslational modification] 1114970010979 intermolecular recognition site; other site 1114970010980 dimerization interface [polypeptide binding]; other site 1114970010981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970010982 DNA binding residues [nucleotide binding] 1114970010983 dimerization interface [polypeptide binding]; other site 1114970010984 PAS domain S-box; Region: sensory_box; TIGR00229 1114970010985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970010986 putative active site [active] 1114970010987 heme pocket [chemical binding]; other site 1114970010988 PAS fold; Region: PAS_4; pfam08448 1114970010989 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970010990 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970010991 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970010992 putative active site [active] 1114970010993 heme pocket [chemical binding]; other site 1114970010994 Histidine kinase; Region: HisKA_3; pfam07730 1114970010995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1114970010996 Cache domain; Region: Cache_1; pfam02743 1114970010997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1114970010998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970010999 dimer interface [polypeptide binding]; other site 1114970011000 phosphorylation site [posttranslational modification] 1114970011001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970011002 ATP binding site [chemical binding]; other site 1114970011003 Mg2+ binding site [ion binding]; other site 1114970011004 G-X-G motif; other site 1114970011005 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1114970011006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970011007 active site 1114970011008 phosphorylation site [posttranslational modification] 1114970011009 intermolecular recognition site; other site 1114970011010 dimerization interface [polypeptide binding]; other site 1114970011011 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114970011012 Zn2+ binding site [ion binding]; other site 1114970011013 Mg2+ binding site [ion binding]; other site 1114970011014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970011015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011016 putative substrate translocation pore; other site 1114970011017 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1114970011018 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1114970011019 YCII-related domain; Region: YCII; cl00999 1114970011020 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970011021 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1114970011022 dimer interface [polypeptide binding]; other site 1114970011023 OPT oligopeptide transporter protein; Region: OPT; cl14607 1114970011024 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970011025 Helix-turn-helix domains; Region: HTH; cl00088 1114970011026 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970011027 putative effector binding pocket; other site 1114970011028 dimerization interface [polypeptide binding]; other site 1114970011029 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1114970011030 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1114970011031 NADP binding site [chemical binding]; other site 1114970011032 dimer interface [polypeptide binding]; other site 1114970011033 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1114970011034 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 1114970011035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970011036 GAF domain; Region: GAF_2; pfam13185 1114970011037 GAF domain; Region: GAF; cl15785 1114970011038 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970011039 metal binding site [ion binding]; metal-binding site 1114970011040 active site 1114970011041 I-site; other site 1114970011042 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970011043 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1114970011044 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1114970011045 substrate binding site [chemical binding]; other site 1114970011046 ligand binding site [chemical binding]; other site 1114970011047 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1114970011048 substrate binding site [chemical binding]; other site 1114970011049 transcriptional activator TtdR; Provisional; Region: PRK09801 1114970011050 Helix-turn-helix domains; Region: HTH; cl00088 1114970011051 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1114970011052 putative effector binding pocket; other site 1114970011053 putative dimerization interface [polypeptide binding]; other site 1114970011054 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1114970011055 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 1114970011056 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1114970011057 Citrate synthase; Region: Citrate_synt; pfam00285 1114970011058 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1114970011059 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1114970011060 oxalacetate binding site [chemical binding]; other site 1114970011061 citrylCoA binding site [chemical binding]; other site 1114970011062 coenzyme A binding site [chemical binding]; other site 1114970011063 catalytic triad [active] 1114970011064 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1114970011065 Citrate transporter; Region: CitMHS; pfam03600 1114970011066 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970011067 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1114970011068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970011069 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1114970011070 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 1114970011071 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114970011072 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1114970011073 Secretory lipase; Region: LIP; pfam03583 1114970011074 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1114970011075 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970011076 DNA binding residues [nucleotide binding] 1114970011077 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1114970011078 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1114970011079 glutamine binding [chemical binding]; other site 1114970011080 catalytic triad [active] 1114970011081 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1114970011082 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114970011083 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1114970011084 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1114970011085 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970011086 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970011087 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1114970011088 EamA-like transporter family; Region: EamA; cl01037 1114970011089 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970011090 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1114970011091 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3; Region: PLPDE_III_DSD_D-TA_like_3; cd06814 1114970011092 dimer interface [polypeptide binding]; other site 1114970011093 active site 1114970011094 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970011095 substrate binding site [chemical binding]; other site 1114970011096 catalytic residue [active] 1114970011097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011098 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1114970011099 putative substrate translocation pore; other site 1114970011100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970011101 Helix-turn-helix domains; Region: HTH; cl00088 1114970011102 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1114970011103 putative dimerization interface [polypeptide binding]; other site 1114970011104 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1114970011105 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1114970011106 Helix-turn-helix domains; Region: HTH; cl00088 1114970011107 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1114970011108 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970011109 dimerization interface [polypeptide binding]; other site 1114970011110 hypothetical protein; Provisional; Region: PRK06102 1114970011111 Amidase; Region: Amidase; cl11426 1114970011112 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970011113 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114970011114 Na binding site [ion binding]; other site 1114970011115 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1114970011116 dimer interface [polypeptide binding]; other site 1114970011117 metal binding site [ion binding]; metal-binding site 1114970011118 Creatinine amidohydrolase; Region: Creatininase; cl00618 1114970011119 LysE type translocator; Region: LysE; cl00565 1114970011120 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 1114970011121 Helix-turn-helix domains; Region: HTH; cl00088 1114970011122 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114970011123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011124 putative substrate translocation pore; other site 1114970011125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970011126 Helix-turn-helix domains; Region: HTH; cl00088 1114970011127 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1114970011128 putative dimerization interface [polypeptide binding]; other site 1114970011129 PrpF protein; Region: PrpF; pfam04303 1114970011130 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1114970011131 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1114970011132 Citrate transporter; Region: CitMHS; pfam03600 1114970011133 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970011134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011135 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1114970011136 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1114970011137 NAD binding site [chemical binding]; other site 1114970011138 homotetramer interface [polypeptide binding]; other site 1114970011139 homodimer interface [polypeptide binding]; other site 1114970011140 substrate binding site [chemical binding]; other site 1114970011141 active site 1114970011142 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1114970011143 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114970011144 Walker A/P-loop; other site 1114970011145 ATP binding site [chemical binding]; other site 1114970011146 Q-loop/lid; other site 1114970011147 ABC transporter signature motif; other site 1114970011148 Walker B; other site 1114970011149 D-loop; other site 1114970011150 H-loop/switch region; other site 1114970011151 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970011152 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114970011153 Walker A/P-loop; other site 1114970011154 ATP binding site [chemical binding]; other site 1114970011155 Q-loop/lid; other site 1114970011156 ABC transporter signature motif; other site 1114970011157 Walker B; other site 1114970011158 D-loop; other site 1114970011159 H-loop/switch region; other site 1114970011160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970011161 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1114970011162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970011163 dimer interface [polypeptide binding]; other site 1114970011164 conserved gate region; other site 1114970011165 putative PBP binding loops; other site 1114970011166 ABC-ATPase subunit interface; other site 1114970011167 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1114970011168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970011169 dimer interface [polypeptide binding]; other site 1114970011170 conserved gate region; other site 1114970011171 putative PBP binding loops; other site 1114970011172 ABC-ATPase subunit interface; other site 1114970011173 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1114970011174 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1114970011175 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1114970011176 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1114970011177 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1114970011178 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970011179 catalytic residue [active] 1114970011180 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114970011181 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114970011182 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114970011183 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1114970011184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970011185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970011186 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1114970011187 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114970011188 active site 1114970011189 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1114970011190 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1114970011191 active site 1114970011192 catalytic site [active] 1114970011193 substrate binding site [chemical binding]; other site 1114970011194 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970011195 Coenzyme A binding pocket [chemical binding]; other site 1114970011196 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1114970011197 Helix-turn-helix domains; Region: HTH; cl00088 1114970011198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970011199 dimerization interface [polypeptide binding]; other site 1114970011200 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970011201 arsenical pump membrane protein; Provisional; Region: PRK15445 1114970011202 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1114970011203 transmembrane helices; other site 1114970011204 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 1114970011205 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1114970011206 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 1114970011207 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1114970011208 active site 1114970011209 metal binding site [ion binding]; metal-binding site 1114970011210 Rhomboid family; Region: Rhomboid; cl11446 1114970011211 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 1114970011212 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1114970011213 aminopeptidase N; Provisional; Region: pepN; PRK14015 1114970011214 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1114970011215 active site 1114970011216 Zn binding site [ion binding]; other site 1114970011217 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1114970011218 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1114970011219 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970011220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970011221 DNA-binding site [nucleotide binding]; DNA binding site 1114970011222 FCD domain; Region: FCD; cl11656 1114970011223 Dehydratase family; Region: ILVD_EDD; cl00340 1114970011224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011225 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1114970011226 putative substrate translocation pore; other site 1114970011227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1114970011228 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1114970011229 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970011230 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1114970011231 dimer interface [polypeptide binding]; other site 1114970011232 NADP binding site [chemical binding]; other site 1114970011233 catalytic residues [active] 1114970011234 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1114970011235 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970011236 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114970011237 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 1114970011238 putative N-terminal domain interface [polypeptide binding]; other site 1114970011239 putative dimer interface [polypeptide binding]; other site 1114970011240 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970011241 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970011242 AAA domain; Region: AAA_23; pfam13476 1114970011243 Walker A/P-loop; other site 1114970011244 ATP binding site [chemical binding]; other site 1114970011245 Q-loop/lid; other site 1114970011246 exonuclease subunit SbcC; Provisional; Region: PRK10246 1114970011247 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970011248 ABC transporter signature motif; other site 1114970011249 Walker B; other site 1114970011250 D-loop; other site 1114970011251 H-loop/switch region; other site 1114970011252 exonuclease subunit SbcD; Provisional; Region: PRK10966 1114970011253 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1114970011254 active site 1114970011255 metal binding site [ion binding]; metal-binding site 1114970011256 DNA binding site [nucleotide binding] 1114970011257 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1114970011258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011259 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1114970011260 putative substrate translocation pore; other site 1114970011261 peptide synthase; Provisional; Region: PRK12467 1114970011262 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970011263 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114970011264 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114970011265 active site 1114970011266 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114970011267 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114970011268 putative NADP binding site [chemical binding]; other site 1114970011269 active site 1114970011270 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 1114970011271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970011272 S-adenosylmethionine binding site [chemical binding]; other site 1114970011273 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970011274 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970011275 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114970011276 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114970011277 active site 1114970011278 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114970011279 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1114970011280 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1114970011281 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970011282 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1114970011283 catalytic triad [active] 1114970011284 dimer interface [polypeptide binding]; other site 1114970011285 conserved cis-peptide bond; other site 1114970011286 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114970011287 putative NADP binding site [chemical binding]; other site 1114970011288 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1114970011289 active site 1114970011290 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970011291 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114970011292 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114970011293 active site 1114970011294 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114970011295 putative NADP binding site [chemical binding]; other site 1114970011296 active site 1114970011297 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970011298 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114970011299 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114970011300 active site 1114970011301 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114970011302 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114970011303 active site 1114970011304 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970011305 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970011306 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1114970011307 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1114970011308 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114970011309 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970011310 Walker A/P-loop; other site 1114970011311 ATP binding site [chemical binding]; other site 1114970011312 Q-loop/lid; other site 1114970011313 ABC transporter signature motif; other site 1114970011314 Walker B; other site 1114970011315 D-loop; other site 1114970011316 H-loop/switch region; other site 1114970011317 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114970011318 Oxygen tolerance; Region: BatD; pfam13584 1114970011319 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970011320 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114970011321 metal ion-dependent adhesion site (MIDAS); other site 1114970011322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970011323 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1114970011324 TPR motif; other site 1114970011325 binding surface 1114970011326 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1114970011327 metal ion-dependent adhesion site (MIDAS); other site 1114970011328 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1114970011329 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1114970011330 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114970011331 MoxR-like ATPases [General function prediction only]; Region: COG0714 1114970011332 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970011333 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114970011334 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1114970011335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970011336 Walker A/P-loop; other site 1114970011337 ATP binding site [chemical binding]; other site 1114970011338 Q-loop/lid; other site 1114970011339 ABC transporter signature motif; other site 1114970011340 Walker B; other site 1114970011341 D-loop; other site 1114970011342 H-loop/switch region; other site 1114970011343 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1114970011344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970011345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011346 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970011347 putative substrate translocation pore; other site 1114970011348 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114970011349 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114970011350 substrate binding site [chemical binding]; other site 1114970011351 ATP binding site [chemical binding]; other site 1114970011352 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1114970011353 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970011354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970011355 DNA binding site [nucleotide binding] 1114970011356 domain linker motif; other site 1114970011357 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1114970011358 putative dimerization interface [polypeptide binding]; other site 1114970011359 putative ligand binding site [chemical binding]; other site 1114970011360 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1114970011361 Cupin domain; Region: Cupin_2; cl09118 1114970011362 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114970011363 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970011364 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970011365 DNA-binding site [nucleotide binding]; DNA binding site 1114970011366 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970011367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970011368 homodimer interface [polypeptide binding]; other site 1114970011369 catalytic residue [active] 1114970011370 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970011371 Secretin and TonB N terminus short domain; Region: STN; cl06624 1114970011372 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1114970011373 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1114970011374 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970011375 FecR protein; Region: FecR; pfam04773 1114970011376 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 1114970011377 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1114970011378 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1114970011379 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1114970011380 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1114970011381 Type II transport protein GspH; Region: GspH; pfam12019 1114970011382 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 1114970011383 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1114970011384 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1114970011385 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1114970011386 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1114970011387 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1114970011388 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1114970011389 GspL periplasmic domain; Region: GspL_C; cl14909 1114970011390 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 1114970011391 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1114970011392 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970011393 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970011394 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970011395 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970011396 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1114970011397 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1114970011398 Walker A motif; other site 1114970011399 ATP binding site [chemical binding]; other site 1114970011400 Walker B motif; other site 1114970011401 type II secretion system protein F; Region: GspF; TIGR02120 1114970011402 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1114970011403 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1114970011404 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970011405 haemagglutination activity domain; Region: Haemagg_act; cl05436 1114970011406 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 1114970011407 CHASE4 domain; Region: CHASE4; cl01308 1114970011408 PAS domain S-box; Region: sensory_box; TIGR00229 1114970011409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970011410 putative active site [active] 1114970011411 heme pocket [chemical binding]; other site 1114970011412 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970011413 metal binding site [ion binding]; metal-binding site 1114970011414 active site 1114970011415 I-site; other site 1114970011416 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970011417 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 1114970011418 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1114970011419 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1114970011420 PYR/PP interface [polypeptide binding]; other site 1114970011421 dimer interface [polypeptide binding]; other site 1114970011422 tetramer interface [polypeptide binding]; other site 1114970011423 TPP binding site [chemical binding]; other site 1114970011424 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1114970011425 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1114970011426 TPP-binding site [chemical binding]; other site 1114970011427 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1114970011428 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1114970011429 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970011430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114970011431 dimer interface [polypeptide binding]; other site 1114970011432 phosphorylation site [posttranslational modification] 1114970011433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970011434 ATP binding site [chemical binding]; other site 1114970011435 Mg2+ binding site [ion binding]; other site 1114970011436 G-X-G motif; other site 1114970011437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970011438 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1114970011439 active site 1114970011440 phosphorylation site [posttranslational modification] 1114970011441 intermolecular recognition site; other site 1114970011442 dimerization interface [polypeptide binding]; other site 1114970011443 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970011444 DNA binding site [nucleotide binding] 1114970011445 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1114970011446 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1114970011447 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1114970011448 catalytic residues [active] 1114970011449 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1114970011450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970011451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970011452 Walker A motif; other site 1114970011453 ATP binding site [chemical binding]; other site 1114970011454 Walker B motif; other site 1114970011455 arginine finger; other site 1114970011456 Helix-turn-helix domains; Region: HTH; cl00088 1114970011457 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1114970011458 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1114970011459 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1114970011460 tetramer interface [polypeptide binding]; other site 1114970011461 TPP-binding site [chemical binding]; other site 1114970011462 heterodimer interface [polypeptide binding]; other site 1114970011463 phosphorylation loop region [posttranslational modification] 1114970011464 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1114970011465 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1114970011466 alpha subunit interface [polypeptide binding]; other site 1114970011467 TPP binding site [chemical binding]; other site 1114970011468 heterodimer interface [polypeptide binding]; other site 1114970011469 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114970011470 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1114970011471 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114970011472 E3 interaction surface; other site 1114970011473 lipoyl attachment site [posttranslational modification]; other site 1114970011474 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970011475 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114970011476 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1114970011477 putative NAD(P) binding site [chemical binding]; other site 1114970011478 catalytic Zn binding site [ion binding]; other site 1114970011479 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1114970011480 DinB superfamily; Region: DinB_2; pfam12867 1114970011481 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1114970011482 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1114970011483 inhibitor site; inhibition site 1114970011484 active site 1114970011485 dimer interface [polypeptide binding]; other site 1114970011486 catalytic residue [active] 1114970011487 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 1114970011488 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1114970011489 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970011490 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970011491 Walker A/P-loop; other site 1114970011492 ATP binding site [chemical binding]; other site 1114970011493 Q-loop/lid; other site 1114970011494 ABC transporter signature motif; other site 1114970011495 Walker B; other site 1114970011496 D-loop; other site 1114970011497 H-loop/switch region; other site 1114970011498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970011499 dimer interface [polypeptide binding]; other site 1114970011500 conserved gate region; other site 1114970011501 putative PBP binding loops; other site 1114970011502 ABC-ATPase subunit interface; other site 1114970011503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970011504 dimer interface [polypeptide binding]; other site 1114970011505 conserved gate region; other site 1114970011506 putative PBP binding loops; other site 1114970011507 ABC-ATPase subunit interface; other site 1114970011508 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 1114970011509 substrate binding site [chemical binding]; other site 1114970011510 Protein of unknown function (DUF521); Region: DUF521; pfam04412 1114970011511 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 1114970011512 substrate binding site [chemical binding]; other site 1114970011513 ligand binding site [chemical binding]; other site 1114970011514 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970011515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970011516 substrate binding pocket [chemical binding]; other site 1114970011517 membrane-bound complex binding site; other site 1114970011518 hinge residues; other site 1114970011519 PAS fold; Region: PAS_4; pfam08448 1114970011520 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970011521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970011522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1114970011523 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1114970011524 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970011525 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 1114970011526 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1114970011527 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970011528 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970011529 DNA-binding site [nucleotide binding]; DNA binding site 1114970011530 FCD domain; Region: FCD; cl11656 1114970011531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011532 putative substrate translocation pore; other site 1114970011533 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970011534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970011535 DNA-binding site [nucleotide binding]; DNA binding site 1114970011536 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970011537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970011538 homodimer interface [polypeptide binding]; other site 1114970011539 catalytic residue [active] 1114970011540 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1114970011541 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970011542 N-terminal plug; other site 1114970011543 ligand-binding site [chemical binding]; other site 1114970011544 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970011545 classical (c) SDRs; Region: SDR_c; cd05233 1114970011546 NAD(P) binding site [chemical binding]; other site 1114970011547 active site 1114970011548 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1114970011549 active site 1 [active] 1114970011550 dimer interface [polypeptide binding]; other site 1114970011551 hexamer interface [polypeptide binding]; other site 1114970011552 active site 2 [active] 1114970011553 Helix-turn-helix domains; Region: HTH; cl00088 1114970011554 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970011555 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970011556 putative effector binding pocket; other site 1114970011557 dimerization interface [polypeptide binding]; other site 1114970011558 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970011559 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1114970011560 Helix-turn-helix domains; Region: HTH; cl00088 1114970011561 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 1114970011562 putative dimerization interface [polypeptide binding]; other site 1114970011563 putative substrate binding pocket [chemical binding]; other site 1114970011564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011565 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970011566 putative substrate translocation pore; other site 1114970011567 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1114970011568 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1114970011569 active site 1114970011570 tetramer interface [polypeptide binding]; other site 1114970011571 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1114970011572 Cytochrome c; Region: Cytochrom_C; cl11414 1114970011573 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1114970011574 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1114970011575 structural tetrad; other site 1114970011576 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1114970011577 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1114970011578 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 1114970011579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970011580 FeS/SAM binding site; other site 1114970011581 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1114970011582 Restriction endonuclease; Region: Mrr_cat; cl00516 1114970011583 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970011584 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970011585 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970011586 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970011587 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1114970011588 Cytochrome c; Region: Cytochrom_C; cl11414 1114970011589 Cytochrome c; Region: Cytochrom_C; cl11414 1114970011590 Cytochrome c; Region: Cytochrom_C; cl11414 1114970011591 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1114970011592 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970011593 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1114970011594 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1114970011595 Subunit I/III interface [polypeptide binding]; other site 1114970011596 Cytochrome c; Region: Cytochrom_C; cl11414 1114970011597 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1114970011598 Low-spin heme binding site [chemical binding]; other site 1114970011599 D-pathway; other site 1114970011600 Binuclear center (active site) [active] 1114970011601 K-pathway; other site 1114970011602 Putative proton exit pathway; other site 1114970011603 Putative water exit pathway; other site 1114970011604 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1114970011605 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1114970011606 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970011607 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1114970011608 ligand binding site [chemical binding]; other site 1114970011609 flexible hinge region; other site 1114970011610 Helix-turn-helix domains; Region: HTH; cl00088 1114970011611 NnrS protein; Region: NnrS; cl01258 1114970011612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 1114970011613 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1114970011614 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 1114970011615 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 1114970011616 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1114970011617 GAF domain; Region: GAF; cl15785 1114970011618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970011619 Walker A motif; other site 1114970011620 ATP binding site [chemical binding]; other site 1114970011621 Walker B motif; other site 1114970011622 arginine finger; other site 1114970011623 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1114970011624 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1114970011625 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1114970011626 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1114970011627 MPT binding site; other site 1114970011628 trimer interface [polypeptide binding]; other site 1114970011629 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1114970011630 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1114970011631 dimer interface [polypeptide binding]; other site 1114970011632 putative functional site; other site 1114970011633 putative MPT binding site; other site 1114970011634 Peptidase family U32; Region: Peptidase_U32; cl03113 1114970011635 Peptidase family U32; Region: Peptidase_U32; cl03113 1114970011636 SCP-2 sterol transfer family; Region: SCP2; cl01225 1114970011637 DGC domain; Region: DGC; cl01742 1114970011638 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1114970011639 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970011640 ligand binding site [chemical binding]; other site 1114970011641 flexible hinge region; other site 1114970011642 Helix-turn-helix domains; Region: HTH; cl00088 1114970011643 transcriptional regulator NarL; Provisional; Region: PRK10651 1114970011644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970011645 active site 1114970011646 phosphorylation site [posttranslational modification] 1114970011647 intermolecular recognition site; other site 1114970011648 dimerization interface [polypeptide binding]; other site 1114970011649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970011650 DNA binding residues [nucleotide binding] 1114970011651 dimerization interface [polypeptide binding]; other site 1114970011652 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 1114970011653 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1114970011654 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970011655 dimerization interface [polypeptide binding]; other site 1114970011656 Histidine kinase; Region: HisKA_3; pfam07730 1114970011657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970011658 ATP binding site [chemical binding]; other site 1114970011659 Mg2+ binding site [ion binding]; other site 1114970011660 G-X-G motif; other site 1114970011661 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1114970011662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011663 putative substrate translocation pore; other site 1114970011664 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1114970011665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011666 putative substrate translocation pore; other site 1114970011667 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1114970011668 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1114970011669 [4Fe-4S] binding site [ion binding]; other site 1114970011670 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114970011671 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114970011672 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114970011673 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1114970011674 molybdopterin cofactor binding site; other site 1114970011675 nitrate reductase, beta subunit; Region: narH; TIGR01660 1114970011676 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1114970011677 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1114970011678 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1114970011679 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1114970011680 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970011681 FeS/SAM binding site; other site 1114970011682 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1114970011683 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 1114970011684 ATP cone domain; Region: ATP-cone; pfam03477 1114970011685 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1114970011686 effector binding site; other site 1114970011687 active site 1114970011688 Zn binding site [ion binding]; other site 1114970011689 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 1114970011690 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 1114970011691 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970011692 FeS/SAM binding site; other site 1114970011693 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970011694 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970011695 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970011696 dimer interface [polypeptide binding]; other site 1114970011697 putative CheW interface [polypeptide binding]; other site 1114970011698 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1114970011699 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1114970011700 Iron permease FTR1 family; Region: FTR1; cl00475 1114970011701 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114970011702 Fe2+ transport protein; Region: Iron_transport; cl01377 1114970011703 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 1114970011704 hypothetical protein; Provisional; Region: PRK06156 1114970011705 hypothetical protein; Provisional; Region: PRK06156 1114970011706 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1114970011707 active site 1114970011708 metal binding site [ion binding]; metal-binding site 1114970011709 Peptidase family U32; Region: Peptidase_U32; cl03113 1114970011710 Collagenase; Region: DUF3656; pfam12392 1114970011711 Cache domain; Region: Cache_1; pfam02743 1114970011712 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970011713 metal binding site [ion binding]; metal-binding site 1114970011714 active site 1114970011715 I-site; other site 1114970011716 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1114970011717 active site 1114970011718 metal binding site [ion binding]; metal-binding site 1114970011719 homotetramer interface [polypeptide binding]; other site 1114970011720 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1114970011721 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 1114970011722 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1114970011723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970011724 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1114970011725 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1114970011726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970011727 short chain dehydrogenase; Provisional; Region: PRK06101 1114970011728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970011729 NAD(P) binding site [chemical binding]; other site 1114970011730 active site 1114970011731 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970011732 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1114970011733 FMN binding site [chemical binding]; other site 1114970011734 active site 1114970011735 substrate binding site [chemical binding]; other site 1114970011736 catalytic residue [active] 1114970011737 Pirin-related protein [General function prediction only]; Region: COG1741 1114970011738 Cupin domain; Region: Cupin_2; cl09118 1114970011739 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970011740 Helix-turn-helix domains; Region: HTH; cl00088 1114970011741 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970011742 putative effector binding pocket; other site 1114970011743 dimerization interface [polypeptide binding]; other site 1114970011744 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1114970011745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970011746 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114970011747 homotrimer interaction site [polypeptide binding]; other site 1114970011748 putative active site [active] 1114970011749 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1114970011750 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1114970011751 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 1114970011752 metal binding site [ion binding]; metal-binding site 1114970011753 putative dimer interface [polypeptide binding]; other site 1114970011754 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1114970011755 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970011756 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970011757 Helix-turn-helix domains; Region: HTH; cl00088 1114970011758 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1114970011759 putative substrate binding pocket [chemical binding]; other site 1114970011760 dimerization interface [polypeptide binding]; other site 1114970011761 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1114970011762 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970011763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970011764 intermolecular recognition site; other site 1114970011765 active site 1114970011766 dimerization interface [polypeptide binding]; other site 1114970011767 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1114970011768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970011769 active site 1114970011770 phosphorylation site [posttranslational modification] 1114970011771 intermolecular recognition site; other site 1114970011772 dimerization interface [polypeptide binding]; other site 1114970011773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970011774 DNA binding residues [nucleotide binding] 1114970011775 dimerization interface [polypeptide binding]; other site 1114970011776 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1114970011777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970011778 dimer interface [polypeptide binding]; other site 1114970011779 phosphorylation site [posttranslational modification] 1114970011780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970011781 ATP binding site [chemical binding]; other site 1114970011782 G-X-G motif; other site 1114970011783 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1114970011784 Helix-turn-helix domains; Region: HTH; cl00088 1114970011785 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970011786 dimerization interface [polypeptide binding]; other site 1114970011787 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970011788 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1114970011789 conserved cys residue [active] 1114970011790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970011791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970011792 transcriptional regulator EutR; Provisional; Region: PRK10130 1114970011793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970011794 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1114970011795 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970011796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011797 amidase; Provisional; Region: PRK07869 1114970011798 Amidase; Region: Amidase; cl11426 1114970011799 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1114970011800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970011801 dimer interface [polypeptide binding]; other site 1114970011802 conserved gate region; other site 1114970011803 putative PBP binding loops; other site 1114970011804 ABC-ATPase subunit interface; other site 1114970011805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1114970011806 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1114970011807 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970011808 Walker A/P-loop; other site 1114970011809 ATP binding site [chemical binding]; other site 1114970011810 Q-loop/lid; other site 1114970011811 ABC transporter signature motif; other site 1114970011812 Walker B; other site 1114970011813 D-loop; other site 1114970011814 H-loop/switch region; other site 1114970011815 NMT1-like family; Region: NMT1_2; cl15260 1114970011816 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 1114970011817 Phosphate transporter family; Region: PHO4; cl00396 1114970011818 Phosphate transporter family; Region: PHO4; cl00396 1114970011819 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1114970011820 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 1114970011821 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1114970011822 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1114970011823 dimer interface [polypeptide binding]; other site 1114970011824 active site 1114970011825 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970011826 catalytic residues [active] 1114970011827 substrate binding site [chemical binding]; other site 1114970011828 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1114970011829 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114970011830 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114970011831 MULE transposase domain; Region: MULE; pfam10551 1114970011832 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970011833 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114970011834 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 1114970011835 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1114970011836 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114970011837 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 1114970011838 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1114970011839 active site 1114970011840 catalytic residues [active] 1114970011841 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970011842 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114970011843 active site 1114970011844 catalytic tetrad [active] 1114970011845 DNA polymerase II; Reviewed; Region: PRK05762 1114970011846 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1114970011847 active site 1114970011848 catalytic site [active] 1114970011849 substrate binding site [chemical binding]; other site 1114970011850 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1114970011851 active site 1114970011852 metal-binding site 1114970011853 FOG: CBS domain [General function prediction only]; Region: COG0517 1114970011854 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1114970011855 Paraquat-inducible protein A; Region: PqiA; pfam04403 1114970011856 Paraquat-inducible protein A; Region: PqiA; pfam04403 1114970011857 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1114970011858 mce related protein; Region: MCE; pfam02470 1114970011859 mce related protein; Region: MCE; pfam02470 1114970011860 mce related protein; Region: MCE; pfam02470 1114970011861 Protein of unknown function (DUF330); Region: DUF330; cl01135 1114970011862 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970011863 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114970011864 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1114970011865 dimer interface [polypeptide binding]; other site 1114970011866 N-terminal domain interface [polypeptide binding]; other site 1114970011867 substrate binding pocket (H-site) [chemical binding]; other site 1114970011868 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1114970011869 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1114970011870 dimer interface [polypeptide binding]; other site 1114970011871 active site 1114970011872 Schiff base residues; other site 1114970011873 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1114970011874 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1114970011875 C-terminal domain interface [polypeptide binding]; other site 1114970011876 GSH binding site (G-site) [chemical binding]; other site 1114970011877 dimer interface [polypeptide binding]; other site 1114970011878 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1114970011879 dimer interface [polypeptide binding]; other site 1114970011880 N-terminal domain interface [polypeptide binding]; other site 1114970011881 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1114970011882 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1114970011883 active site residue [active] 1114970011884 selenophosphate synthetase; Provisional; Region: PRK00943 1114970011885 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1114970011886 dimerization interface [polypeptide binding]; other site 1114970011887 putative ATP binding site [chemical binding]; other site 1114970011888 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1114970011889 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1114970011890 Predicted esterase [General function prediction only]; Region: COG0400 1114970011891 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970011892 Predicted deacylase [General function prediction only]; Region: COG3608 1114970011893 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1114970011894 active site 1114970011895 Zn binding site [ion binding]; other site 1114970011896 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1114970011897 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970011898 substrate binding pocket [chemical binding]; other site 1114970011899 membrane-bound complex binding site; other site 1114970011900 hinge residues; other site 1114970011901 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1114970011902 active site residue [active] 1114970011903 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1114970011904 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1114970011905 conserved cys residue [active] 1114970011906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970011907 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1114970011908 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1114970011909 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114970011910 catalytic core [active] 1114970011911 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114970011912 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114970011913 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114970011914 putative active site [active] 1114970011915 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970011916 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1114970011917 catalytic triad [active] 1114970011918 conserved cis-peptide bond; other site 1114970011919 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1114970011920 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970011921 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1114970011922 Spore germination protein; Region: Spore_permease; cl15802 1114970011923 amino acid transporter; Region: 2A0306; TIGR00909 1114970011924 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1114970011925 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1114970011926 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 1114970011927 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1114970011928 tetramer interface [polypeptide binding]; other site 1114970011929 active site 1114970011930 Mg2+/Mn2+ binding site [ion binding]; other site 1114970011931 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970011932 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1114970011933 FAD binding site [chemical binding]; other site 1114970011934 substrate binding site [chemical binding]; other site 1114970011935 catalytic base [active] 1114970011936 Helix-turn-helix domains; Region: HTH; cl00088 1114970011937 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970011938 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114970011939 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1114970011940 MerR, DNA binding; Region: MerR-DNA-bind; pfam09278 1114970011941 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1114970011942 AMP-binding domain protein; Validated; Region: PRK08315 1114970011943 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970011944 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970011945 isovaleryl-CoA dehydrogenase; Region: PLN02519 1114970011946 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1114970011947 substrate binding site [chemical binding]; other site 1114970011948 FAD binding site [chemical binding]; other site 1114970011949 catalytic base [active] 1114970011950 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1114970011951 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114970011952 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114970011953 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 1114970011954 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970011955 substrate binding site [chemical binding]; other site 1114970011956 oxyanion hole (OAH) forming residues; other site 1114970011957 trimer interface [polypeptide binding]; other site 1114970011958 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1114970011959 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970011960 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970011961 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1114970011962 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970011963 carboxyltransferase (CT) interaction site; other site 1114970011964 biotinylation site [posttranslational modification]; other site 1114970011965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970011966 non-specific DNA binding site [nucleotide binding]; other site 1114970011967 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1114970011968 salt bridge; other site 1114970011969 sequence-specific DNA binding site [nucleotide binding]; other site 1114970011970 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970011971 Catalytic site [active] 1114970011972 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1114970011973 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1114970011974 active site 1114970011975 Zn binding site [ion binding]; other site 1114970011976 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1114970011977 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1114970011978 putative heme binding pocket [chemical binding]; other site 1114970011979 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 1114970011980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970011981 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970011982 DNA binding residues [nucleotide binding] 1114970011983 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1114970011984 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970011985 Helix-turn-helix domains; Region: HTH; cl00088 1114970011986 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970011987 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970011988 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970011989 Walker A/P-loop; other site 1114970011990 ATP binding site [chemical binding]; other site 1114970011991 Q-loop/lid; other site 1114970011992 ABC transporter signature motif; other site 1114970011993 Walker B; other site 1114970011994 D-loop; other site 1114970011995 H-loop/switch region; other site 1114970011996 TOBE domain; Region: TOBE_2; cl01440 1114970011997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970011998 dimer interface [polypeptide binding]; other site 1114970011999 conserved gate region; other site 1114970012000 putative PBP binding loops; other site 1114970012001 ABC-ATPase subunit interface; other site 1114970012002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970012003 dimer interface [polypeptide binding]; other site 1114970012004 conserved gate region; other site 1114970012005 putative PBP binding loops; other site 1114970012006 ABC-ATPase subunit interface; other site 1114970012007 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1114970012008 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1114970012009 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1114970012010 FAD dependent oxidoreductase; Region: DAO; pfam01266 1114970012011 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970012012 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114970012013 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1114970012014 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1114970012015 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970012016 active site 1114970012017 ATP binding site [chemical binding]; other site 1114970012018 substrate binding site [chemical binding]; other site 1114970012019 activation loop (A-loop); other site 1114970012020 Transcriptional regulator; Region: Transcrip_reg; cl00361 1114970012021 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1114970012022 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970012023 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1114970012024 D-cysteine desulfhydrase; Validated; Region: PRK03910 1114970012025 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1114970012026 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970012027 catalytic residue [active] 1114970012028 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1114970012029 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1114970012030 active site 1114970012031 FMN binding site [chemical binding]; other site 1114970012032 2,4-decadienoyl-CoA binding site; other site 1114970012033 catalytic residue [active] 1114970012034 4Fe-4S cluster binding site [ion binding]; other site 1114970012035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970012036 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 1114970012037 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1114970012038 active site 1114970012039 catalytic triad [active] 1114970012040 dimer interface [polypeptide binding]; other site 1114970012041 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970012042 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970012043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970012044 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 1114970012045 periplasmic folding chaperone; Provisional; Region: PRK10788 1114970012046 SurA N-terminal domain; Region: SurA_N_3; cl07813 1114970012047 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1114970012048 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114970012049 IHF - DNA interface [nucleotide binding]; other site 1114970012050 IHF dimer interface [polypeptide binding]; other site 1114970012051 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1114970012052 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1114970012053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970012054 Walker A motif; other site 1114970012055 ATP binding site [chemical binding]; other site 1114970012056 Walker B motif; other site 1114970012057 arginine finger; other site 1114970012058 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1114970012059 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1114970012060 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1114970012061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970012062 Walker A motif; other site 1114970012063 ATP binding site [chemical binding]; other site 1114970012064 Walker B motif; other site 1114970012065 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1114970012066 Clp protease; Region: CLP_protease; pfam00574 1114970012067 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1114970012068 oligomer interface [polypeptide binding]; other site 1114970012069 active site residues [active] 1114970012070 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 1114970012071 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1114970012072 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1114970012073 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1114970012074 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1114970012075 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1114970012076 homodimer interface [polypeptide binding]; other site 1114970012077 NADP binding site [chemical binding]; other site 1114970012078 substrate binding site [chemical binding]; other site 1114970012079 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1114970012080 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970012081 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 1114970012082 putative active site [active] 1114970012083 Integral membrane protein TerC family; Region: TerC; cl10468 1114970012084 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1114970012085 Helix-turn-helix domains; Region: HTH; cl00088 1114970012086 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1114970012087 putative dimerization interface [polypeptide binding]; other site 1114970012088 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114970012089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970012090 putative substrate translocation pore; other site 1114970012091 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114970012092 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 1114970012093 Protein of unknown function, DUF480; Region: DUF480; cl01209 1114970012094 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1114970012095 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1114970012096 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114970012097 shikimate binding site; other site 1114970012098 NAD(P) binding site [chemical binding]; other site 1114970012099 xanthine permease; Region: pbuX; TIGR03173 1114970012100 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1114970012101 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1114970012102 putative catalytic site [active] 1114970012103 putative phosphate binding site [ion binding]; other site 1114970012104 active site 1114970012105 metal binding site A [ion binding]; metal-binding site 1114970012106 DNA binding site [nucleotide binding] 1114970012107 putative AP binding site [nucleotide binding]; other site 1114970012108 putative metal binding site B [ion binding]; other site 1114970012109 Cache domain; Region: Cache_1; pfam02743 1114970012110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970012111 metal binding site [ion binding]; metal-binding site 1114970012112 active site 1114970012113 I-site; other site 1114970012114 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1114970012115 B1 nucleotide binding pocket [chemical binding]; other site 1114970012116 B2 nucleotide binding pocket [chemical binding]; other site 1114970012117 CAS motifs; other site 1114970012118 active site 1114970012119 Chromate transporter; Region: Chromate_transp; pfam02417 1114970012120 Chromate transporter; Region: Chromate_transp; pfam02417 1114970012121 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970012122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970012123 putative substrate translocation pore; other site 1114970012124 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114970012125 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1114970012126 putative NAD(P) binding site [chemical binding]; other site 1114970012127 putative substrate binding site [chemical binding]; other site 1114970012128 catalytic Zn binding site [ion binding]; other site 1114970012129 structural Zn binding site [ion binding]; other site 1114970012130 dimer interface [polypeptide binding]; other site 1114970012131 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1114970012132 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970012133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970012134 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114970012135 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114970012136 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114970012137 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114970012138 cell density-dependent motility repressor; Provisional; Region: PRK10082 1114970012139 Helix-turn-helix domains; Region: HTH; cl00088 1114970012140 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970012141 dimerization interface [polypeptide binding]; other site 1114970012142 Fic/DOC family; Region: Fic; cl00960 1114970012143 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1114970012144 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1114970012145 active site 1114970012146 metal binding site [ion binding]; metal-binding site 1114970012147 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1114970012148 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1114970012149 FMN binding site [chemical binding]; other site 1114970012150 active site 1114970012151 catalytic residues [active] 1114970012152 substrate binding site [chemical binding]; other site 1114970012153 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1114970012154 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1114970012155 anti sigma factor interaction site; other site 1114970012156 regulatory phosphorylation site [posttranslational modification]; other site 1114970012157 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970012158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970012159 active site 1114970012160 phosphorylation site [posttranslational modification] 1114970012161 intermolecular recognition site; other site 1114970012162 dimerization interface [polypeptide binding]; other site 1114970012163 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1114970012164 VacJ like lipoprotein; Region: VacJ; cl01073 1114970012165 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1114970012166 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 1114970012167 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1114970012168 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1114970012169 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114970012170 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1114970012171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970012172 active site 1114970012173 phosphorylation site [posttranslational modification] 1114970012174 intermolecular recognition site; other site 1114970012175 dimerization interface [polypeptide binding]; other site 1114970012176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970012177 DNA binding site [nucleotide binding] 1114970012178 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1114970012179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970012180 dimer interface [polypeptide binding]; other site 1114970012181 phosphorylation site [posttranslational modification] 1114970012182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970012183 ATP binding site [chemical binding]; other site 1114970012184 Mg2+ binding site [ion binding]; other site 1114970012185 G-X-G motif; other site 1114970012186 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1114970012187 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114970012188 FtsX-like permease family; Region: FtsX; cl15850 1114970012189 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970012190 ABC transporter; Region: ABC_tran; pfam00005 1114970012191 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1114970012192 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1114970012193 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114970012194 FtsX-like permease family; Region: FtsX; cl15850 1114970012195 PilZ domain; Region: PilZ; cl01260 1114970012196 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1114970012197 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1114970012198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1114970012199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970012200 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114970012201 ApbE family; Region: ApbE; cl00643 1114970012202 citrate-proton symporter; Provisional; Region: PRK15075 1114970012203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970012204 putative substrate translocation pore; other site 1114970012205 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1114970012206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970012207 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1114970012208 transcription-repair coupling factor; Provisional; Region: PRK10689 1114970012209 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1114970012210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970012211 ATP binding site [chemical binding]; other site 1114970012212 putative Mg++ binding site [ion binding]; other site 1114970012213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970012214 nucleotide binding region [chemical binding]; other site 1114970012215 ATP-binding site [chemical binding]; other site 1114970012216 TRCF domain; Region: TRCF; cl04088 1114970012217 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1114970012218 Uncharacterized conserved protein [Function unknown]; Region: COG4715 1114970012219 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1114970012220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970012221 ATP binding site [chemical binding]; other site 1114970012222 putative Mg++ binding site [ion binding]; other site 1114970012223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970012224 nucleotide binding region [chemical binding]; other site 1114970012225 ATP-binding site [chemical binding]; other site 1114970012226 Uncharacterized conserved protein [Function unknown]; Region: COG4715 1114970012227 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1114970012228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970012229 ATP binding site [chemical binding]; other site 1114970012230 putative Mg++ binding site [ion binding]; other site 1114970012231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970012232 nucleotide binding region [chemical binding]; other site 1114970012233 ATP-binding site [chemical binding]; other site 1114970012234 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1114970012235 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1114970012236 Helix-turn-helix domains; Region: HTH; cl00088 1114970012237 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 1114970012238 LexA repressor; Validated; Region: PRK00215 1114970012239 Helix-turn-helix domains; Region: HTH; cl00088 1114970012240 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970012241 Catalytic site [active] 1114970012242 Cell division inhibitor SulA; Region: SulA; cl01880 1114970012243 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1114970012244 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1114970012245 active site 1114970012246 interdomain interaction site; other site 1114970012247 putative metal-binding site [ion binding]; other site 1114970012248 nucleotide binding site [chemical binding]; other site 1114970012249 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1114970012250 domain I; other site 1114970012251 DNA binding groove [nucleotide binding] 1114970012252 phosphate binding site [ion binding]; other site 1114970012253 domain II; other site 1114970012254 domain III; other site 1114970012255 nucleotide binding site [chemical binding]; other site 1114970012256 catalytic site [active] 1114970012257 domain IV; other site 1114970012258 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1114970012259 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1114970012260 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1114970012261 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 1114970012262 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1114970012263 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970012264 dimer interface [polypeptide binding]; other site 1114970012265 active site 1114970012266 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1114970012267 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970012268 substrate binding site [chemical binding]; other site 1114970012269 oxyanion hole (OAH) forming residues; other site 1114970012270 trimer interface [polypeptide binding]; other site 1114970012271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970012272 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970012273 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1114970012274 ABC transporter ATPase component; Reviewed; Region: PRK11147 1114970012275 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114970012276 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114970012277 ABC transporter; Region: ABC_tran_2; pfam12848 1114970012278 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114970012279 lytic murein transglycosylase; Provisional; Region: PRK11619 1114970012280 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1114970012281 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970012282 catalytic residue [active] 1114970012283 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1114970012284 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114970012285 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970012286 Walker A/P-loop; other site 1114970012287 ATP binding site [chemical binding]; other site 1114970012288 Q-loop/lid; other site 1114970012289 ABC transporter signature motif; other site 1114970012290 Walker B; other site 1114970012291 D-loop; other site 1114970012292 H-loop/switch region; other site 1114970012293 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 1114970012294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970012295 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 1114970012296 multidrug efflux protein; Reviewed; Region: PRK01766 1114970012297 MatE; Region: MatE; cl10513 1114970012298 MatE; Region: MatE; cl10513 1114970012299 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1114970012300 CPxP motif; other site 1114970012301 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1114970012302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970012303 aconitate hydratase; Validated; Region: PRK09277 1114970012304 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1114970012305 substrate binding site [chemical binding]; other site 1114970012306 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1114970012307 ligand binding site [chemical binding]; other site 1114970012308 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1114970012309 substrate binding site [chemical binding]; other site 1114970012310 CAAX protease self-immunity; Region: Abi; cl00558 1114970012311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970012312 PAS domain; Region: PAS_9; pfam13426 1114970012313 putative active site [active] 1114970012314 heme pocket [chemical binding]; other site 1114970012315 L-lactate permease; Region: Lactate_perm; cl00701 1114970012316 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970012317 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970012318 dimer interface [polypeptide binding]; other site 1114970012319 putative CheW interface [polypeptide binding]; other site 1114970012320 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1114970012321 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1114970012322 Low-spin heme binding site [chemical binding]; other site 1114970012323 Putative water exit pathway; other site 1114970012324 Binuclear center (active site) [active] 1114970012325 Putative proton exit pathway; other site 1114970012326 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1114970012327 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 1114970012328 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 1114970012329 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1114970012330 Cytochrome c; Region: Cytochrom_C; cl11414 1114970012331 Cytochrome c; Region: Cytochrom_C; cl11414 1114970012332 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1114970012333 Low-spin heme binding site [chemical binding]; other site 1114970012334 Putative water exit pathway; other site 1114970012335 Binuclear center (active site) [active] 1114970012336 Putative proton exit pathway; other site 1114970012337 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1114970012338 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 1114970012339 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1114970012340 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1114970012341 Cytochrome c; Region: Cytochrom_C; cl11414 1114970012342 Cytochrome c; Region: Cytochrom_C; cl11414 1114970012343 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1114970012344 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1114970012345 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1114970012346 FixH; Region: FixH; cl01254 1114970012347 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1114970012348 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114970012349 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114970012350 metal-binding site [ion binding] 1114970012351 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114970012352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970012353 motif II; other site 1114970012354 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 1114970012355 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1114970012356 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1114970012357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970012358 FeS/SAM binding site; other site 1114970012359 HemN C-terminal domain; Region: HemN_C; pfam06969 1114970012360 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1114970012361 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970012362 ligand binding site [chemical binding]; other site 1114970012363 flexible hinge region; other site 1114970012364 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1114970012365 putative switch regulator; other site 1114970012366 non-specific DNA interactions [nucleotide binding]; other site 1114970012367 DNA binding site [nucleotide binding] 1114970012368 sequence specific DNA binding site [nucleotide binding]; other site 1114970012369 putative cAMP binding site [chemical binding]; other site 1114970012370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970012371 active site 1114970012372 recombination protein RecR; Reviewed; Region: recR; PRK00076 1114970012373 RecR protein; Region: RecR; pfam02132 1114970012374 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1114970012375 putative active site [active] 1114970012376 putative metal-binding site [ion binding]; other site 1114970012377 tetramer interface [polypeptide binding]; other site 1114970012378 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1114970012379 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1114970012380 NAD(P) binding site [chemical binding]; other site 1114970012381 substrate binding site [chemical binding]; other site 1114970012382 dimer interface [polypeptide binding]; other site 1114970012383 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1114970012384 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1114970012385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970012386 Walker A motif; other site 1114970012387 ATP binding site [chemical binding]; other site 1114970012388 Walker B motif; other site 1114970012389 arginine finger; other site 1114970012390 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1114970012391 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1114970012392 PAS domain; Region: PAS_9; pfam13426 1114970012393 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970012394 putative active site [active] 1114970012395 heme pocket [chemical binding]; other site 1114970012396 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970012397 metal binding site [ion binding]; metal-binding site 1114970012398 active site 1114970012399 I-site; other site 1114970012400 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970012401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970012402 non-specific DNA binding site [nucleotide binding]; other site 1114970012403 salt bridge; other site 1114970012404 sequence-specific DNA binding site [nucleotide binding]; other site 1114970012405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1114970012406 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1114970012407 Ligase N family; Region: LIGANc; smart00532 1114970012408 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1114970012409 nucleotide binding pocket [chemical binding]; other site 1114970012410 K-X-D-G motif; other site 1114970012411 catalytic site [active] 1114970012412 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1114970012413 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1114970012414 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1114970012415 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1114970012416 Dimer interface [polypeptide binding]; other site 1114970012417 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 1114970012418 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1114970012419 FtsZ protein binding site [polypeptide binding]; other site 1114970012420 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1114970012421 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1114970012422 Walker A/P-loop; other site 1114970012423 ATP binding site [chemical binding]; other site 1114970012424 Q-loop/lid; other site 1114970012425 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 1114970012426 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1114970012427 ABC transporter signature motif; other site 1114970012428 Walker B; other site 1114970012429 D-loop; other site 1114970012430 H-loop/switch region; other site 1114970012431 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970012432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970012433 DNA-binding site [nucleotide binding]; DNA binding site 1114970012434 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1114970012435 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970012436 catalytic loop [active] 1114970012437 iron binding site [ion binding]; other site 1114970012438 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1114970012439 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 1114970012440 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1114970012441 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1114970012442 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970012443 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1114970012444 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1114970012445 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1114970012446 guanine deaminase; Provisional; Region: PRK09228 1114970012447 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1114970012448 active site 1114970012449 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970012450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970012451 DNA-binding site [nucleotide binding]; DNA binding site 1114970012452 FCD domain; Region: FCD; cl11656 1114970012453 benzoate transporter; Region: benE; TIGR00843 1114970012454 Benzoate membrane transport protein; Region: BenE; pfam03594 1114970012455 Protein with unknown function (DUF469); Region: DUF469; cl01237 1114970012456 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1114970012457 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970012458 CHASE domain; Region: CHASE; cl01369 1114970012459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970012460 PAS domain; Region: PAS_9; pfam13426 1114970012461 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1114970012462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970012463 PAS fold; Region: PAS_3; pfam08447 1114970012464 putative active site [active] 1114970012465 heme pocket [chemical binding]; other site 1114970012466 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970012467 metal binding site [ion binding]; metal-binding site 1114970012468 active site 1114970012469 I-site; other site 1114970012470 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1114970012471 THUMP domain; Region: THUMP; cl12076 1114970012472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970012473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970012474 S-adenosylmethionine binding site [chemical binding]; other site 1114970012475 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1114970012476 quinone interaction residues [chemical binding]; other site 1114970012477 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 1114970012478 active site 1114970012479 catalytic residues [active] 1114970012480 FMN binding site [chemical binding]; other site 1114970012481 substrate binding site [chemical binding]; other site 1114970012482 Integrase core domain; Region: rve_3; cl15866 1114970012483 Helix-turn-helix domains; Region: HTH; cl00088 1114970012484 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1114970012485 putative dimer interface [polypeptide binding]; other site 1114970012486 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1114970012487 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1114970012488 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1114970012489 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1114970012490 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1114970012491 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1114970012492 metal binding site [ion binding]; metal-binding site 1114970012493 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1114970012494 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 1114970012495 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114970012496 ABC-ATPase subunit interface; other site 1114970012497 dimer interface [polypeptide binding]; other site 1114970012498 putative PBP binding regions; other site 1114970012499 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114970012500 intersubunit interface [polypeptide binding]; other site 1114970012501 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1114970012502 PrpF protein; Region: PrpF; pfam04303 1114970012503 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1114970012504 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1114970012505 substrate binding site [chemical binding]; other site 1114970012506 ligand binding site [chemical binding]; other site 1114970012507 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1114970012508 substrate binding site [chemical binding]; other site 1114970012509 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 1114970012510 dimer interface [polypeptide binding]; other site 1114970012511 Citrate synthase; Region: Citrate_synt; pfam00285 1114970012512 active site 1114970012513 citrylCoA binding site [chemical binding]; other site 1114970012514 oxalacetate/citrate binding site [chemical binding]; other site 1114970012515 coenzyme A binding site [chemical binding]; other site 1114970012516 catalytic triad [active] 1114970012517 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 1114970012518 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1114970012519 tetramer interface [polypeptide binding]; other site 1114970012520 active site 1114970012521 Mg2+/Mn2+ binding site [ion binding]; other site 1114970012522 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970012523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970012524 DNA-binding site [nucleotide binding]; DNA binding site 1114970012525 FCD domain; Region: FCD; cl11656 1114970012526 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 1114970012527 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 1114970012528 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1114970012529 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970012530 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1114970012531 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114970012532 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1114970012533 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114970012534 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1114970012535 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1114970012536 Active Sites [active] 1114970012537 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1114970012538 Na binding site [ion binding]; other site 1114970012539 putative substrate binding site [chemical binding]; other site 1114970012540 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114970012541 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970012542 Helix-turn-helix domains; Region: HTH; cl00088 1114970012543 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970012544 putative effector binding pocket; other site 1114970012545 dimerization interface [polypeptide binding]; other site 1114970012546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970012547 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114970012548 NAD(P) binding site [chemical binding]; other site 1114970012549 active site 1114970012550 hydrolase; Region: PLN02811 1114970012551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970012552 motif II; other site 1114970012553 PAS fold; Region: PAS_4; pfam08448 1114970012554 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1114970012555 GAF domain; Region: GAF; cl15785 1114970012556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970012557 dimer interface [polypeptide binding]; other site 1114970012558 phosphorylation site [posttranslational modification] 1114970012559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970012560 ATP binding site [chemical binding]; other site 1114970012561 Mg2+ binding site [ion binding]; other site 1114970012562 G-X-G motif; other site 1114970012563 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970012564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970012565 active site 1114970012566 phosphorylation site [posttranslational modification] 1114970012567 intermolecular recognition site; other site 1114970012568 dimerization interface [polypeptide binding]; other site 1114970012569 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1114970012570 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1114970012571 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970012572 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970012573 Helix-turn-helix domains; Region: HTH; cl00088 1114970012574 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970012575 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114970012576 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1114970012577 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970012578 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970012579 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1114970012580 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970012581 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1114970012582 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114970012583 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970012584 Coenzyme A binding pocket [chemical binding]; other site 1114970012585 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1114970012586 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114970012587 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114970012588 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970012589 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1114970012590 active site 1114970012591 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114970012592 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1114970012593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970012594 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 1114970012595 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 1114970012596 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970012597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970012598 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1114970012599 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970012600 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1114970012601 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970012602 substrate binding site [chemical binding]; other site 1114970012603 oxyanion hole (OAH) forming residues; other site 1114970012604 trimer interface [polypeptide binding]; other site 1114970012605 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114970012606 putative acyl-acceptor binding pocket; other site 1114970012607 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1114970012608 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1114970012609 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1114970012610 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1114970012611 catalytic triad [active] 1114970012612 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1114970012613 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970012614 substrate binding site [chemical binding]; other site 1114970012615 oxyanion hole (OAH) forming residues; other site 1114970012616 trimer interface [polypeptide binding]; other site 1114970012617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970012618 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970012619 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1114970012620 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970012621 dimer interface [polypeptide binding]; other site 1114970012622 active site 1114970012623 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114970012624 Cytochrome c; Region: Cytochrom_C; cl11414 1114970012625 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1114970012626 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1114970012627 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 1114970012628 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1114970012629 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 1114970012630 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1114970012631 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 1114970012632 putative lipid binding site [chemical binding]; other site 1114970012633 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970012634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970012635 DNA-binding site [nucleotide binding]; DNA binding site 1114970012636 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970012637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970012638 homodimer interface [polypeptide binding]; other site 1114970012639 catalytic residue [active] 1114970012640 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970012641 ligand binding site [chemical binding]; other site 1114970012642 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1114970012643 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970012644 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970012645 substrate binding pocket [chemical binding]; other site 1114970012646 membrane-bound complex binding site; other site 1114970012647 hinge residues; other site 1114970012648 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1114970012649 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1114970012650 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1114970012651 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1114970012652 Ligand binding site [chemical binding]; other site 1114970012653 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1114970012654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970012655 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1114970012656 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1114970012657 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1114970012658 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970012659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970012660 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114970012661 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1114970012662 putative NAD(P) binding site [chemical binding]; other site 1114970012663 putative substrate binding site [chemical binding]; other site 1114970012664 catalytic Zn binding site [ion binding]; other site 1114970012665 structural Zn binding site [ion binding]; other site 1114970012666 dimer interface [polypeptide binding]; other site 1114970012667 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970012668 Helix-turn-helix domains; Region: HTH; cl00088 1114970012669 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970012670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970012671 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970012672 putative substrate translocation pore; other site 1114970012673 galactonate dehydratase; Provisional; Region: PRK14017 1114970012674 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1114970012675 putative active site pocket [active] 1114970012676 putative metal binding site [ion binding]; other site 1114970012677 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1114970012678 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1114970012679 active site 1114970012680 intersubunit interface [polypeptide binding]; other site 1114970012681 catalytic residue [active] 1114970012682 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1114970012683 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1114970012684 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970012685 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1114970012686 putative C-terminal domain interface [polypeptide binding]; other site 1114970012687 putative GSH binding site (G-site) [chemical binding]; other site 1114970012688 putative dimer interface [polypeptide binding]; other site 1114970012689 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1114970012690 putative N-terminal domain interface [polypeptide binding]; other site 1114970012691 putative dimer interface [polypeptide binding]; other site 1114970012692 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970012693 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114970012694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970012695 Coenzyme A binding pocket [chemical binding]; other site 1114970012696 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1114970012697 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114970012698 TM-ABC transporter signature motif; other site 1114970012699 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1114970012700 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 1114970012701 Walker A/P-loop; other site 1114970012702 ATP binding site [chemical binding]; other site 1114970012703 Q-loop/lid; other site 1114970012704 ABC transporter signature motif; other site 1114970012705 Walker B; other site 1114970012706 D-loop; other site 1114970012707 H-loop/switch region; other site 1114970012708 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1114970012709 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1114970012710 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1114970012711 ligand binding site [chemical binding]; other site 1114970012712 short chain dehydrogenase; Provisional; Region: PRK07063 1114970012713 classical (c) SDRs; Region: SDR_c; cd05233 1114970012714 NAD(P) binding site [chemical binding]; other site 1114970012715 active site 1114970012716 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1114970012717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970012718 DNA-binding site [nucleotide binding]; DNA binding site 1114970012719 FCD domain; Region: FCD; cl11656 1114970012720 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 1114970012721 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1114970012722 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970012723 FeS/SAM binding site; other site 1114970012724 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1114970012725 Helix-turn-helix domains; Region: HTH; cl00088 1114970012726 WHG domain; Region: WHG; pfam13305 1114970012727 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1114970012728 active site 1114970012729 PilZ domain; Region: PilZ; cl01260 1114970012730 DNA polymerase III subunit delta'; Validated; Region: PRK05707 1114970012731 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970012732 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970012733 thymidylate kinase; Validated; Region: tmk; PRK00698 1114970012734 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1114970012735 TMP-binding site; other site 1114970012736 ATP-binding site [chemical binding]; other site 1114970012737 YceG-like family; Region: YceG; pfam02618 1114970012738 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1114970012739 dimerization interface [polypeptide binding]; other site 1114970012740 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1114970012741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970012742 catalytic residue [active] 1114970012743 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1114970012744 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114970012745 dimer interface [polypeptide binding]; other site 1114970012746 active site 1114970012747 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970012748 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114970012749 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1114970012750 NAD(P) binding site [chemical binding]; other site 1114970012751 homotetramer interface [polypeptide binding]; other site 1114970012752 homodimer interface [polypeptide binding]; other site 1114970012753 active site 1114970012754 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1114970012755 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114970012756 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1114970012757 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 1114970012758 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1114970012759 Maf-like protein; Region: Maf; pfam02545 1114970012760 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1114970012761 active site 1114970012762 dimer interface [polypeptide binding]; other site 1114970012763 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1114970012764 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1114970012765 tandem repeat interface [polypeptide binding]; other site 1114970012766 oligomer interface [polypeptide binding]; other site 1114970012767 active site residues [active] 1114970012768 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1114970012769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970012770 motif II; other site 1114970012771 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1114970012772 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1114970012773 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114970012774 active site 1114970012775 ribonuclease E; Reviewed; Region: rne; PRK10811 1114970012776 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1114970012777 homodimer interface [polypeptide binding]; other site 1114970012778 oligonucleotide binding site [chemical binding]; other site 1114970012779 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1114970012780 Ligand binding site; other site 1114970012781 metal-binding site 1114970012782 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1114970012783 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1114970012784 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1114970012785 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1114970012786 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970012787 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1114970012788 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970012789 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970012790 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1114970012791 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1114970012792 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1114970012793 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1114970012794 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970012795 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1114970012796 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1114970012797 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1114970012798 active site 1114970012799 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1114970012800 Ligand binding site; other site 1114970012801 oligomer interface; other site 1114970012802 Trm112p-like protein; Region: Trm112p; cl01066 1114970012803 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 1114970012804 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1114970012805 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1114970012806 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114970012807 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1114970012808 Competence protein; Region: Competence; cl00471 1114970012809 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970012810 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 1114970012811 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114970012812 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114970012813 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970012814 Walker A/P-loop; other site 1114970012815 ATP binding site [chemical binding]; other site 1114970012816 Q-loop/lid; other site 1114970012817 ABC transporter signature motif; other site 1114970012818 Walker B; other site 1114970012819 D-loop; other site 1114970012820 H-loop/switch region; other site 1114970012821 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970012822 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1114970012823 putative C-terminal domain interface [polypeptide binding]; other site 1114970012824 putative GSH binding site (G-site) [chemical binding]; other site 1114970012825 putative dimer interface [polypeptide binding]; other site 1114970012826 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1114970012827 putative N-terminal domain interface [polypeptide binding]; other site 1114970012828 putative dimer interface [polypeptide binding]; other site 1114970012829 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970012830 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1114970012831 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1114970012832 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1114970012833 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1114970012834 active site 1114970012835 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1114970012836 transcriptional activator TtdR; Provisional; Region: PRK09801 1114970012837 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970012838 putative effector binding pocket; other site 1114970012839 dimerization interface [polypeptide binding]; other site 1114970012840 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1114970012841 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1114970012842 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1114970012843 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970012844 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 1114970012845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970012846 binding surface 1114970012847 TPR motif; other site 1114970012848 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 1114970012849 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1114970012850 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1114970012851 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1114970012852 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1114970012853 ATP binding site [chemical binding]; other site 1114970012854 Walker A motif; other site 1114970012855 hexamer interface [polypeptide binding]; other site 1114970012856 Walker B motif; other site 1114970012857 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970012858 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 1114970012859 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1114970012860 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 1114970012861 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1114970012862 TadE-like protein; Region: TadE; cl10688 1114970012863 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1114970012864 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970012865 Walker A motif; other site 1114970012866 ATP binding site [chemical binding]; other site 1114970012867 Walker B motif; other site 1114970012868 arginine finger; other site 1114970012869 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 1114970012870 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970012871 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970012872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970012873 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970012874 Predicted membrane protein [Function unknown]; Region: COG2364 1114970012875 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 1114970012876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970012877 FeS/SAM binding site; other site 1114970012878 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970012879 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970012880 catalytic residue [active] 1114970012881 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1114970012882 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970012883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970012884 homodimer interface [polypeptide binding]; other site 1114970012885 catalytic residue [active] 1114970012886 LysE type translocator; Region: LysE; cl00565 1114970012887 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970012888 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970012889 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970012890 dimer interface [polypeptide binding]; other site 1114970012891 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970012892 putative CheW interface [polypeptide binding]; other site 1114970012893 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970012894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970012895 DNA-binding site [nucleotide binding]; DNA binding site 1114970012896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970012897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970012898 homodimer interface [polypeptide binding]; other site 1114970012899 catalytic residue [active] 1114970012900 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1114970012901 classical (c) SDRs; Region: SDR_c; cd05233 1114970012902 NAD(P) binding site [chemical binding]; other site 1114970012903 active site 1114970012904 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1114970012905 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1114970012906 NAD(P) binding site [chemical binding]; other site 1114970012907 substrate binding site [chemical binding]; other site 1114970012908 dimer interface [polypeptide binding]; other site 1114970012909 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 1114970012910 active site 1114970012911 dimer interface [polypeptide binding]; other site 1114970012912 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1114970012913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970012914 active site 1114970012915 phosphorylation site [posttranslational modification] 1114970012916 intermolecular recognition site; other site 1114970012917 dimerization interface [polypeptide binding]; other site 1114970012918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970012919 DNA binding site [nucleotide binding] 1114970012920 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970012921 dimerization interface [polypeptide binding]; other site 1114970012922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114970012923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970012924 ATP binding site [chemical binding]; other site 1114970012925 Mg2+ binding site [ion binding]; other site 1114970012926 G-X-G motif; other site 1114970012927 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1114970012928 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970012929 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970012930 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114970012931 CoenzymeA binding site [chemical binding]; other site 1114970012932 subunit interaction site [polypeptide binding]; other site 1114970012933 PHB binding site; other site 1114970012934 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114970012935 catalytic core [active] 1114970012936 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1114970012937 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1114970012938 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970012939 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1114970012940 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1114970012941 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970012942 N-terminal plug; other site 1114970012943 ligand-binding site [chemical binding]; other site 1114970012944 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1114970012945 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970012946 dimerization interface [polypeptide binding]; other site 1114970012947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970012948 dimer interface [polypeptide binding]; other site 1114970012949 phosphorylation site [posttranslational modification] 1114970012950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970012951 ATP binding site [chemical binding]; other site 1114970012952 Mg2+ binding site [ion binding]; other site 1114970012953 G-X-G motif; other site 1114970012954 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970012955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970012956 active site 1114970012957 phosphorylation site [posttranslational modification] 1114970012958 intermolecular recognition site; other site 1114970012959 dimerization interface [polypeptide binding]; other site 1114970012960 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1114970012961 active site 1 [active] 1114970012962 dimer interface [polypeptide binding]; other site 1114970012963 active site 2 [active] 1114970012964 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1114970012965 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114970012966 dimer interface [polypeptide binding]; other site 1114970012967 active site 1114970012968 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 1114970012969 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114970012970 Cupin domain; Region: Cupin_2; cl09118 1114970012971 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1114970012972 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1114970012973 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970012974 heat shock protein 90; Provisional; Region: PRK05218 1114970012975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970012976 ATP binding site [chemical binding]; other site 1114970012977 Mg2+ binding site [ion binding]; other site 1114970012978 G-X-G motif; other site 1114970012979 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114970012980 CoenzymeA binding site [chemical binding]; other site 1114970012981 subunit interaction site [polypeptide binding]; other site 1114970012982 PHB binding site; other site 1114970012983 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114970012984 CoenzymeA binding site [chemical binding]; other site 1114970012985 subunit interaction site [polypeptide binding]; other site 1114970012986 PHB binding site; other site 1114970012987 Protein of unknown function, DUF599; Region: DUF599; cl01575 1114970012988 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1114970012989 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1114970012990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970012991 CoA-ligase; Region: Ligase_CoA; cl02894 1114970012992 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1114970012993 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970012994 CoA-ligase; Region: Ligase_CoA; cl02894 1114970012995 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1114970012996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970012997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970012998 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114970012999 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1114970013000 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114970013001 E3 interaction surface; other site 1114970013002 lipoyl attachment site [posttranslational modification]; other site 1114970013003 e3 binding domain; Region: E3_binding; pfam02817 1114970013004 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1114970013005 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1114970013006 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1114970013007 TPP-binding site [chemical binding]; other site 1114970013008 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1114970013009 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1114970013010 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1114970013011 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 1114970013012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970013013 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1114970013014 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1114970013015 SdhC subunit interface [polypeptide binding]; other site 1114970013016 proximal heme binding site [chemical binding]; other site 1114970013017 cardiolipin binding site; other site 1114970013018 Iron-sulfur protein interface; other site 1114970013019 proximal quinone binding site [chemical binding]; other site 1114970013020 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1114970013021 SdhD (CybS) interface [polypeptide binding]; other site 1114970013022 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1114970013023 dimer interface [polypeptide binding]; other site 1114970013024 Citrate synthase; Region: Citrate_synt; pfam00285 1114970013025 active site 1114970013026 citrylCoA binding site [chemical binding]; other site 1114970013027 NADH binding [chemical binding]; other site 1114970013028 cationic pore residues; other site 1114970013029 oxalacetate/citrate binding site [chemical binding]; other site 1114970013030 coenzyme A binding site [chemical binding]; other site 1114970013031 catalytic triad [active] 1114970013032 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1114970013033 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1114970013034 Na binding site [ion binding]; other site 1114970013035 Protein of unknown function, DUF485; Region: DUF485; cl01231 1114970013036 NMT1-like family; Region: NMT1_2; cl15260 1114970013037 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114970013038 VacJ like lipoprotein; Region: VacJ; cl01073 1114970013039 Protein of unknown function (DUF808); Region: DUF808; cl01002 1114970013040 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1114970013041 Helix-turn-helix domains; Region: HTH; cl00088 1114970013042 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1114970013043 Transposase IS200 like; Region: Y1_Tnp; cl00848 1114970013044 Domain of unknown function (DUF336); Region: DUF336; cl01249 1114970013045 glyoxylate carboligase; Provisional; Region: PRK11269 1114970013046 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114970013047 PYR/PP interface [polypeptide binding]; other site 1114970013048 dimer interface [polypeptide binding]; other site 1114970013049 TPP binding site [chemical binding]; other site 1114970013050 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1114970013051 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1114970013052 TPP-binding site [chemical binding]; other site 1114970013053 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1114970013054 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1114970013055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970013056 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1114970013057 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1114970013058 MOFRL family; Region: MOFRL; pfam05161 1114970013059 pyruvate kinase; Provisional; Region: PRK06247 1114970013060 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1114970013061 domain interfaces; other site 1114970013062 active site 1114970013063 Urea transporter; Region: UT; cl01829 1114970013064 Ion transport protein; Region: Ion_trans; pfam00520 1114970013065 Ion channel; Region: Ion_trans_2; cl11596 1114970013066 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970013067 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1114970013068 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114970013069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970013070 putative substrate translocation pore; other site 1114970013071 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1114970013072 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1114970013073 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1114970013074 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1114970013075 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970013076 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1114970013077 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1114970013078 Cupin domain; Region: Cupin_2; cl09118 1114970013079 MFS_1 like family; Region: MFS_1_like; pfam12832 1114970013080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970013081 putative substrate translocation pore; other site 1114970013082 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1114970013083 Tetramer interface [polypeptide binding]; other site 1114970013084 active site 1114970013085 FMN-binding site [chemical binding]; other site 1114970013086 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970013087 HemK family putative methylases; Region: hemK_fam; TIGR00536 1114970013088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970013089 S-adenosylmethionine binding site [chemical binding]; other site 1114970013090 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1114970013091 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970013092 catalytic triad [active] 1114970013093 conserved cis-peptide bond; other site 1114970013094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1114970013095 Smr domain; Region: Smr; cl02619 1114970013096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970013097 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1114970013098 cofactor binding site; other site 1114970013099 DNA binding site [nucleotide binding] 1114970013100 substrate interaction site [chemical binding]; other site 1114970013101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1114970013102 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1114970013103 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1114970013104 active site 1114970013105 DNA binding site [nucleotide binding] 1114970013106 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1114970013107 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970013108 Catalytic site [active] 1114970013109 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1114970013110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970013111 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1114970013112 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1114970013113 catalytic residue [active] 1114970013114 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1114970013115 Phage Tail Protein X; Region: Phage_tail_X; cl02088 1114970013116 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1114970013117 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 1114970013118 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1114970013119 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1114970013120 Phage tail tube protein FII; Region: Phage_tube; cl01390 1114970013121 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1114970013122 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1114970013123 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1114970013124 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 1114970013125 Baseplate J-like protein; Region: Baseplate_J; cl01294 1114970013126 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1114970013127 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1114970013128 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970013129 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1114970013130 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1114970013131 Clp protease; Region: CLP_protease; pfam00574 1114970013132 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1114970013133 oligomer interface [polypeptide binding]; other site 1114970013134 active site residues [active] 1114970013135 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 1114970013136 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 1114970013137 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 1114970013138 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1114970013139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1114970013140 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1114970013141 active site 1114970013142 metal binding site [ion binding]; metal-binding site 1114970013143 interdomain interaction site; other site 1114970013144 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 1114970013145 Virulence-associated protein E; Region: VirE; pfam05272 1114970013146 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1114970013147 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970013148 Catalytic site [active] 1114970013149 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 1114970013150 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 1114970013151 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114970013152 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1114970013153 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1114970013154 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1114970013155 active site 1114970013156 DNA binding site [nucleotide binding] 1114970013157 Int/Topo IB signature motif; other site 1114970013158 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1114970013159 GTP cyclohydrolase I; Provisional; Region: PLN03044 1114970013160 homodecamer interface [polypeptide binding]; other site 1114970013161 active site 1114970013162 putative catalytic site residues [active] 1114970013163 zinc binding site [ion binding]; other site 1114970013164 GTP-CH-I/GFRP interaction surface; other site 1114970013165 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114970013166 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1114970013167 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970013168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970013169 homodimer interface [polypeptide binding]; other site 1114970013170 catalytic residue [active] 1114970013171 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970013172 Helix-turn-helix domains; Region: HTH; cl00088 1114970013173 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114970013174 MULE transposase domain; Region: MULE; pfam10551 1114970013175 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1114970013176 LysE type translocator; Region: LysE; cl00565 1114970013177 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1114970013178 active site 1114970013179 homotetramer interface [polypeptide binding]; other site 1114970013180 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1114970013181 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1114970013182 active site 1114970013183 catalytic site [active] 1114970013184 tetramer interface [polypeptide binding]; other site 1114970013185 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 1114970013186 allantoicase; Provisional; Region: PRK13257 1114970013187 Allantoicase repeat; Region: Allantoicase; pfam03561 1114970013188 Allantoicase repeat; Region: Allantoicase; pfam03561 1114970013189 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1114970013190 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 1114970013191 Predicted membrane protein [Function unknown]; Region: COG3748 1114970013192 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1114970013193 Cytochrome c; Region: Cytochrom_C; cl11414 1114970013194 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1114970013195 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1114970013196 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1114970013197 active site 1114970013198 nucleophile elbow; other site 1114970013199 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1114970013200 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1114970013201 putative acyl-acceptor binding pocket; other site 1114970013202 septum formation inhibitor; Reviewed; Region: minC; PRK00339 1114970013203 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1114970013204 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1114970013205 cell division inhibitor MinD; Provisional; Region: PRK10818 1114970013206 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1114970013207 Switch I; other site 1114970013208 Switch II; other site 1114970013209 Septum formation topological specificity factor MinE; Region: MinE; cl00538 1114970013210 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114970013211 active site 1114970013212 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1114970013213 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1114970013214 active site 1114970013215 metal binding site [ion binding]; metal-binding site 1114970013216 transcriptional regulator protein; Region: phnR; TIGR03337 1114970013217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970013218 DNA-binding site [nucleotide binding]; DNA binding site 1114970013219 UTRA domain; Region: UTRA; cl01230 1114970013220 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970013221 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114970013222 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1114970013223 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 1114970013224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970013225 dimer interface [polypeptide binding]; other site 1114970013226 conserved gate region; other site 1114970013227 putative PBP binding loops; other site 1114970013228 ABC-ATPase subunit interface; other site 1114970013229 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970013230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970013231 dimer interface [polypeptide binding]; other site 1114970013232 conserved gate region; other site 1114970013233 ABC-ATPase subunit interface; other site 1114970013234 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970013235 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970013236 Walker A/P-loop; other site 1114970013237 ATP binding site [chemical binding]; other site 1114970013238 Q-loop/lid; other site 1114970013239 ABC transporter signature motif; other site 1114970013240 Walker B; other site 1114970013241 D-loop; other site 1114970013242 H-loop/switch region; other site 1114970013243 TOBE domain; Region: TOBE_2; cl01440 1114970013244 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1114970013245 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114970013246 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 1114970013247 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 1114970013248 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1114970013249 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1114970013250 NAD(P) binding site [chemical binding]; other site 1114970013251 carboxy-terminal protease; Provisional; Region: PRK11186 1114970013252 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1114970013253 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1114970013254 protein binding site [polypeptide binding]; other site 1114970013255 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1114970013256 Catalytic dyad [active] 1114970013257 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1114970013258 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970013259 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1114970013260 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970013261 metal binding site [ion binding]; metal-binding site 1114970013262 active site 1114970013263 I-site; other site 1114970013264 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970013265 RHS Repeat; Region: RHS_repeat; cl11982 1114970013266 RHS Repeat; Region: RHS_repeat; cl11982 1114970013267 RHS Repeat; Region: RHS_repeat; cl11982 1114970013268 RHS Repeat; Region: RHS_repeat; cl11982 1114970013269 RHS Repeat; Region: RHS_repeat; cl11982 1114970013270 RHS Repeat; Region: RHS_repeat; cl11982 1114970013271 RHS Repeat; Region: RHS_repeat; cl11982 1114970013272 RHS Repeat; Region: RHS_repeat; cl11982 1114970013273 RHS Repeat; Region: RHS_repeat; cl11982 1114970013274 RHS Repeat; Region: RHS_repeat; cl11982 1114970013275 RHS protein; Region: RHS; pfam03527 1114970013276 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970013277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970013278 non-specific DNA binding site [nucleotide binding]; other site 1114970013279 salt bridge; other site 1114970013280 sequence-specific DNA binding site [nucleotide binding]; other site 1114970013281 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1114970013282 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1114970013283 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1114970013284 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1114970013285 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1114970013286 putative heme binding pocket [chemical binding]; other site 1114970013287 Putative exonuclease, RdgC; Region: RdgC; cl01122 1114970013288 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1114970013289 Membrane transport protein; Region: Mem_trans; cl09117 1114970013290 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114970013291 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 1114970013292 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114970013293 putative acyl-acceptor binding pocket; other site 1114970013294 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 1114970013295 gating phenylalanine in ion channel; other site 1114970013296 Cupin domain; Region: Cupin_2; cl09118 1114970013297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970013298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970013299 Helix-turn-helix domains; Region: HTH; cl00088 1114970013300 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114970013301 Na binding site [ion binding]; other site 1114970013302 PAS fold; Region: PAS_7; pfam12860 1114970013303 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970013304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970013305 dimer interface [polypeptide binding]; other site 1114970013306 phosphorylation site [posttranslational modification] 1114970013307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970013308 ATP binding site [chemical binding]; other site 1114970013309 Mg2+ binding site [ion binding]; other site 1114970013310 G-X-G motif; other site 1114970013311 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970013312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970013313 active site 1114970013314 phosphorylation site [posttranslational modification] 1114970013315 intermolecular recognition site; other site 1114970013316 dimerization interface [polypeptide binding]; other site 1114970013317 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1114970013318 RmuC family; Region: RmuC; pfam02646 1114970013319 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1114970013320 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1114970013321 catalytic residues [active] 1114970013322 dimer interface [polypeptide binding]; other site 1114970013323 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1114970013324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970013325 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970013326 Helix-turn-helix domains; Region: HTH; cl00088 1114970013327 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970013328 DNA binding residues [nucleotide binding] 1114970013329 dimerization interface [polypeptide binding]; other site 1114970013330 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970013331 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970013332 RHS Repeat; Region: RHS_repeat; cl11982 1114970013333 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970013334 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1114970013335 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1114970013336 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1114970013337 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1114970013338 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1114970013339 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114970013340 catalytic core [active] 1114970013341 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1114970013342 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1114970013343 putative dimer interface [polypeptide binding]; other site 1114970013344 active site pocket [active] 1114970013345 putative cataytic base [active] 1114970013346 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1114970013347 homotrimer interface [polypeptide binding]; other site 1114970013348 Walker A motif; other site 1114970013349 GTP binding site [chemical binding]; other site 1114970013350 Walker B motif; other site 1114970013351 cobyric acid synthase; Provisional; Region: PRK00784 1114970013352 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970013353 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970013354 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1114970013355 catalytic triad [active] 1114970013356 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1114970013357 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970013358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970013359 homodimer interface [polypeptide binding]; other site 1114970013360 catalytic residue [active] 1114970013361 CobD/Cbib protein; Region: CobD_Cbib; cl00561 1114970013362 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1114970013363 FMN binding site [chemical binding]; other site 1114970013364 dimer interface [polypeptide binding]; other site 1114970013365 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1114970013366 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1114970013367 catalytic triad [active] 1114970013368 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970013369 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1114970013370 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1114970013371 Walker A motif; other site 1114970013372 homodimer interface [polypeptide binding]; other site 1114970013373 ATP binding site [chemical binding]; other site 1114970013374 hydroxycobalamin binding site [chemical binding]; other site 1114970013375 Walker B motif; other site 1114970013376 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1114970013377 NlpC/P60 family; Region: NLPC_P60; cl11438 1114970013378 NlpC/P60 family; Region: NLPC_P60; cl11438 1114970013379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970013380 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 1114970013381 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114970013382 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1114970013383 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1114970013384 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1114970013385 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1114970013386 dimerization interface [polypeptide binding]; other site 1114970013387 putative ATP binding site [chemical binding]; other site 1114970013388 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1114970013389 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1114970013390 active site 1114970013391 substrate binding site [chemical binding]; other site 1114970013392 cosubstrate binding site; other site 1114970013393 catalytic site [active] 1114970013394 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1114970013395 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 1114970013396 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1114970013397 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1114970013398 homodimer interface [polypeptide binding]; other site 1114970013399 metal binding site [ion binding]; metal-binding site 1114970013400 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 1114970013401 homodimer interface [polypeptide binding]; other site 1114970013402 active site 1114970013403 putative chemical substrate binding site [chemical binding]; other site 1114970013404 metal binding site [ion binding]; metal-binding site 1114970013405 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1114970013406 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114970013407 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1114970013408 synthetase active site [active] 1114970013409 NTP binding site [chemical binding]; other site 1114970013410 metal binding site [ion binding]; metal-binding site 1114970013411 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1114970013412 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1114970013413 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1114970013414 TRAM domain; Region: TRAM; cl01282 1114970013415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970013416 S-adenosylmethionine binding site [chemical binding]; other site 1114970013417 cysteine synthase B; Region: cysM; TIGR01138 1114970013418 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114970013419 dimer interface [polypeptide binding]; other site 1114970013420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970013421 catalytic residue [active] 1114970013422 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1114970013423 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970013424 dimerization interface [polypeptide binding]; other site 1114970013425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970013426 dimer interface [polypeptide binding]; other site 1114970013427 phosphorylation site [posttranslational modification] 1114970013428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970013429 ATP binding site [chemical binding]; other site 1114970013430 Mg2+ binding site [ion binding]; other site 1114970013431 G-X-G motif; other site 1114970013432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970013433 active site 1114970013434 phosphorylation site [posttranslational modification] 1114970013435 intermolecular recognition site; other site 1114970013436 dimerization interface [polypeptide binding]; other site 1114970013437 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1114970013438 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1114970013439 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1114970013440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970013441 META domain; Region: META; cl01245 1114970013442 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114970013443 catalytic residues [active] 1114970013444 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1114970013445 ArsC family; Region: ArsC; pfam03960 1114970013446 catalytic residues [active] 1114970013447 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970013448 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 1114970013449 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1114970013450 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1114970013451 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1114970013452 Ligand Binding Site [chemical binding]; other site 1114970013453 Yip1 domain; Region: Yip1; cl12048 1114970013454 hypothetical protein; Provisional; Region: PRK04860 1114970013455 SprT homologues; Region: SprT; cl01182 1114970013456 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1114970013457 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1114970013458 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114970013459 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114970013460 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970013461 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970013462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970013463 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114970013464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114970013465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970013466 ATP binding site [chemical binding]; other site 1114970013467 Mg2+ binding site [ion binding]; other site 1114970013468 G-X-G motif; other site 1114970013469 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1114970013470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970013471 active site 1114970013472 phosphorylation site [posttranslational modification] 1114970013473 intermolecular recognition site; other site 1114970013474 dimerization interface [polypeptide binding]; other site 1114970013475 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970013476 DNA binding site [nucleotide binding] 1114970013477 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1114970013478 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1114970013479 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970013480 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970013481 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1114970013482 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1114970013483 sensor protein RstB; Provisional; Region: PRK10604 1114970013484 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970013485 dimerization interface [polypeptide binding]; other site 1114970013486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970013487 dimer interface [polypeptide binding]; other site 1114970013488 phosphorylation site [posttranslational modification] 1114970013489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970013490 ATP binding site [chemical binding]; other site 1114970013491 Mg2+ binding site [ion binding]; other site 1114970013492 G-X-G motif; other site 1114970013493 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1114970013494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970013495 active site 1114970013496 phosphorylation site [posttranslational modification] 1114970013497 intermolecular recognition site; other site 1114970013498 dimerization interface [polypeptide binding]; other site 1114970013499 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970013500 DNA binding site [nucleotide binding] 1114970013501 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1114970013502 ATP cone domain; Region: ATP-cone; pfam03477 1114970013503 ATP cone domain; Region: ATP-cone; pfam03477 1114970013504 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1114970013505 active site 1114970013506 dimer interface [polypeptide binding]; other site 1114970013507 catalytic residues [active] 1114970013508 effector binding site; other site 1114970013509 R2 peptide binding site; other site 1114970013510 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1114970013511 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1114970013512 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1114970013513 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114970013514 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1114970013515 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1114970013516 FlgD Ig-like domain; Region: FlgD_ig; cl15790 1114970013517 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1114970013518 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1114970013519 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114970013520 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1114970013521 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1114970013522 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1114970013523 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1114970013524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970013525 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1114970013526 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970013527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970013528 active site 1114970013529 phosphorylation site [posttranslational modification] 1114970013530 intermolecular recognition site; other site 1114970013531 dimerization interface [polypeptide binding]; other site 1114970013532 SAF-like; Region: SAF_2; pfam13144 1114970013533 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1114970013534 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1114970013535 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 1114970013536 FlgN protein; Region: FlgN; cl09176 1114970013537 Flagellar regulator YcgR; Region: YcgR; pfam07317 1114970013538 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1114970013539 PilZ domain; Region: PilZ; cl01260 1114970013540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970013541 putative substrate translocation pore; other site 1114970013542 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970013543 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1114970013544 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970013545 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970013546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970013547 ATP binding site [chemical binding]; other site 1114970013548 Mg2+ binding site [ion binding]; other site 1114970013549 G-X-G motif; other site 1114970013550 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1114970013551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970013552 active site 1114970013553 phosphorylation site [posttranslational modification] 1114970013554 intermolecular recognition site; other site 1114970013555 dimerization interface [polypeptide binding]; other site 1114970013556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114970013557 TPR motif; other site 1114970013558 binding surface 1114970013559 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1114970013560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970013561 binding surface 1114970013562 TPR motif; other site 1114970013563 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 1114970013564 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1114970013565 Restriction endonuclease; Region: Mrr_cat; cl00516 1114970013566 haemagglutination activity domain; Region: Haemagg_act; cl05436 1114970013567 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1114970013568 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970013569 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970013570 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970013571 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970013572 RTX toxin acyltransferase family; Region: HlyC; cl01131 1114970013573 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1114970013574 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1114970013575 Surface antigen; Region: Bac_surface_Ag; cl03097 1114970013576 Arc-like DNA binding domain; Region: Arc; pfam03869 1114970013577 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970013578 LysE type translocator; Region: LysE; cl00565 1114970013579 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1114970013580 MgtE intracellular N domain; Region: MgtE_N; cl15244 1114970013581 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1114970013582 Divalent cation transporter; Region: MgtE; cl00786 1114970013583 Global regulator protein family; Region: CsrA; cl00670 1114970013584 aspartate kinase; Reviewed; Region: PRK06635 1114970013585 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1114970013586 putative nucleotide binding site [chemical binding]; other site 1114970013587 putative catalytic residues [active] 1114970013588 putative Mg ion binding site [ion binding]; other site 1114970013589 putative aspartate binding site [chemical binding]; other site 1114970013590 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1114970013591 putative allosteric regulatory site; other site 1114970013592 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1114970013593 putative allosteric regulatory residue; other site 1114970013594 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1114970013595 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 1114970013596 motif 1; other site 1114970013597 active site 1114970013598 motif 2; other site 1114970013599 motif 3; other site 1114970013600 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1114970013601 DHHA1 domain; Region: DHHA1; pfam02272 1114970013602 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1114970013603 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1114970013604 tetramer interface [polypeptide binding]; other site 1114970013605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970013606 catalytic residue [active] 1114970013607 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 1114970013608 active site 1114970013609 homopentamer interface [polypeptide binding]; other site 1114970013610 dimer interface [polypeptide binding]; other site 1114970013611 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1114970013612 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1114970013613 active site 1114970013614 Zn binding site [ion binding]; other site 1114970013615 Succinylarginine dihydrolase; Region: AstB; cl01511 1114970013616 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970013617 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1114970013618 NAD(P) binding site [chemical binding]; other site 1114970013619 catalytic residues [active] 1114970013620 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1114970013621 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1114970013622 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1114970013623 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970013624 inhibitor-cofactor binding pocket; inhibition site 1114970013625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970013626 catalytic residue [active] 1114970013627 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970013628 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1114970013629 conserved cys residue [active] 1114970013630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970013631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970013632 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1114970013633 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970013634 Walker A/P-loop; other site 1114970013635 ATP binding site [chemical binding]; other site 1114970013636 Q-loop/lid; other site 1114970013637 ABC transporter signature motif; other site 1114970013638 Walker B; other site 1114970013639 D-loop; other site 1114970013640 H-loop/switch region; other site 1114970013641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970013642 dimer interface [polypeptide binding]; other site 1114970013643 conserved gate region; other site 1114970013644 putative PBP binding loops; other site 1114970013645 ABC-ATPase subunit interface; other site 1114970013646 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970013647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970013648 dimer interface [polypeptide binding]; other site 1114970013649 conserved gate region; other site 1114970013650 putative PBP binding loops; other site 1114970013651 ABC-ATPase subunit interface; other site 1114970013652 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1114970013653 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970013654 substrate binding pocket [chemical binding]; other site 1114970013655 membrane-bound complex binding site; other site 1114970013656 hinge residues; other site 1114970013657 acetyl-CoA synthetase; Provisional; Region: PRK00174 1114970013658 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1114970013659 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970013660 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970013661 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1114970013662 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1114970013663 dimer interface [polypeptide binding]; other site 1114970013664 putative radical transfer pathway; other site 1114970013665 diiron center [ion binding]; other site 1114970013666 tyrosyl radical; other site 1114970013667 BRO family, N-terminal domain; Region: Bro-N; cl10591 1114970013668 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970013669 non-specific DNA binding site [nucleotide binding]; other site 1114970013670 salt bridge; other site 1114970013671 sequence-specific DNA binding site [nucleotide binding]; other site 1114970013672 HipA N-terminal domain; Region: Couple_hipA; cl11853 1114970013673 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1114970013674 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1114970013675 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1114970013676 Cupin domain; Region: Cupin_2; cl09118 1114970013677 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970013678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970013679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970013680 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970013681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970013682 Helix-turn-helix domains; Region: HTH; cl00088 1114970013683 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1114970013684 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1114970013685 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970013686 Helix-turn-helix domains; Region: HTH; cl00088 1114970013687 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970013688 dimerization interface [polypeptide binding]; other site 1114970013689 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1114970013690 conserved cys residue [active] 1114970013691 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114970013692 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 1114970013693 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1114970013694 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1114970013695 active site 1114970013696 catalytic site [active] 1114970013697 metal binding site [ion binding]; metal-binding site 1114970013698 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1114970013699 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970013700 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970013701 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970013702 dimer interface [polypeptide binding]; other site 1114970013703 putative CheW interface [polypeptide binding]; other site 1114970013704 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1114970013705 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1114970013706 major facilitator superfamily transporter; Provisional; Region: PRK05122 1114970013707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970013708 putative substrate translocation pore; other site 1114970013709 RF-1 domain; Region: RF-1; cl02875 1114970013710 aromatic amino acid transporter; Provisional; Region: PRK10238 1114970013711 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1114970013712 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1114970013713 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114970013714 RNA binding surface [nucleotide binding]; other site 1114970013715 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1114970013716 probable active site [active] 1114970013717 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 1114970013718 ScpA/B protein; Region: ScpA_ScpB; cl00598 1114970013719 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1114970013720 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1114970013721 Intracellular septation protein A; Region: IspA; cl01098 1114970013722 YCII-related domain; Region: YCII; cl00999 1114970013723 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 1114970013724 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970013725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970013726 active site 1114970013727 phosphorylation site [posttranslational modification] 1114970013728 intermolecular recognition site; other site 1114970013729 dimerization interface [polypeptide binding]; other site 1114970013730 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970013731 DNA binding site [nucleotide binding] 1114970013732 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1114970013733 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1114970013734 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970013735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114970013736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970013737 ATP binding site [chemical binding]; other site 1114970013738 Mg2+ binding site [ion binding]; other site 1114970013739 G-X-G motif; other site 1114970013740 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1114970013741 Imelysin; Region: Peptidase_M75; cl09159 1114970013742 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 1114970013743 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970013744 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970013745 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970013746 multidrug efflux protein; Reviewed; Region: PRK09579 1114970013747 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970013748 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970013749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970013750 S-adenosylmethionine binding site [chemical binding]; other site 1114970013751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970013752 dimer interface [polypeptide binding]; other site 1114970013753 phosphorylation site [posttranslational modification] 1114970013754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970013755 ATP binding site [chemical binding]; other site 1114970013756 Mg2+ binding site [ion binding]; other site 1114970013757 G-X-G motif; other site 1114970013758 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970013759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970013760 active site 1114970013761 phosphorylation site [posttranslational modification] 1114970013762 intermolecular recognition site; other site 1114970013763 dimerization interface [polypeptide binding]; other site 1114970013764 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970013765 DNA binding site [nucleotide binding] 1114970013766 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1114970013767 active site 1114970013768 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1114970013769 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1114970013770 ring oligomerisation interface [polypeptide binding]; other site 1114970013771 ATP/Mg binding site [chemical binding]; other site 1114970013772 stacking interactions; other site 1114970013773 hinge regions; other site 1114970013774 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1114970013775 oligomerisation interface [polypeptide binding]; other site 1114970013776 mobile loop; other site 1114970013777 roof hairpin; other site 1114970013778 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 1114970013779 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1114970013780 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1114970013781 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1114970013782 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970013783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970013784 NAD(P) binding site [chemical binding]; other site 1114970013785 active site 1114970013786 antiporter inner membrane protein; Provisional; Region: PRK11670 1114970013787 Domain of unknown function DUF59; Region: DUF59; cl00941 1114970013788 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1114970013789 Walker A motif; other site 1114970013790 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1114970013791 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1114970013792 active site 1114970013793 HIGH motif; other site 1114970013794 KMSKS motif; other site 1114970013795 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1114970013796 tRNA binding surface [nucleotide binding]; other site 1114970013797 anticodon binding site; other site 1114970013798 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1114970013799 dimer interface [polypeptide binding]; other site 1114970013800 putative tRNA-binding site [nucleotide binding]; other site 1114970013801 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1114970013802 ferredoxin; Provisional; Region: PRK06991 1114970013803 Putative Fe-S cluster; Region: FeS; pfam04060 1114970013804 4Fe-4S binding domain; Region: Fer4; cl02805 1114970013805 4Fe-4S binding domain; Region: Fer4; cl02805 1114970013806 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1114970013807 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1114970013808 FMN-binding domain; Region: FMN_bind; cl01081 1114970013809 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1114970013810 endonuclease III; Provisional; Region: PRK10702 1114970013811 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114970013812 minor groove reading motif; other site 1114970013813 helix-hairpin-helix signature motif; other site 1114970013814 substrate binding pocket [chemical binding]; other site 1114970013815 active site 1114970013816 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1114970013817 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970013818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970013819 active site 1114970013820 phosphorylation site [posttranslational modification] 1114970013821 intermolecular recognition site; other site 1114970013822 dimerization interface [polypeptide binding]; other site 1114970013823 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970013824 DNA binding residues [nucleotide binding] 1114970013825 dimerization interface [polypeptide binding]; other site 1114970013826 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 1114970013827 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1114970013828 ANP binding site [chemical binding]; other site 1114970013829 Substrate Binding Site II [chemical binding]; other site 1114970013830 Substrate Binding Site I [chemical binding]; other site 1114970013831 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970013832 ligand binding site [chemical binding]; other site 1114970013833 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1114970013834 active site 1114970013835 substrate binding pocket [chemical binding]; other site 1114970013836 dimer interface [polypeptide binding]; other site 1114970013837 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1114970013838 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1114970013839 dimer interface [polypeptide binding]; other site 1114970013840 catalytic site [active] 1114970013841 putative active site [active] 1114970013842 putative substrate binding site [chemical binding]; other site 1114970013843 peroxidase; Provisional; Region: PRK15000 1114970013844 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1114970013845 dimer interface [polypeptide binding]; other site 1114970013846 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1114970013847 catalytic triad [active] 1114970013848 peroxidatic and resolving cysteines [active] 1114970013849 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1114970013850 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1114970013851 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1114970013852 heme binding site [chemical binding]; other site 1114970013853 ferroxidase pore; other site 1114970013854 ferroxidase diiron center [ion binding]; other site 1114970013855 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1114970013856 putative GSH binding site [chemical binding]; other site 1114970013857 catalytic residues [active] 1114970013858 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1114970013859 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1114970013860 putative [Fe4-S4] binding site [ion binding]; other site 1114970013861 putative molybdopterin cofactor binding site [chemical binding]; other site 1114970013862 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1114970013863 putative molybdopterin cofactor binding site; other site 1114970013864 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1114970013865 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114970013866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970013867 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970013868 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 1114970013869 Walker A/P-loop; other site 1114970013870 ATP binding site [chemical binding]; other site 1114970013871 Q-loop/lid; other site 1114970013872 ABC transporter signature motif; other site 1114970013873 Walker B; other site 1114970013874 D-loop; other site 1114970013875 H-loop/switch region; other site 1114970013876 TOBE domain; Region: TOBE_2; cl01440 1114970013877 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1114970013878 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1114970013879 putative deacylase active site [active] 1114970013880 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1114970013881 amphipathic channel; other site 1114970013882 Asn-Pro-Ala signature motifs; other site 1114970013883 glycerol kinase; Provisional; Region: glpK; PRK00047 1114970013884 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1114970013885 N- and C-terminal domain interface [polypeptide binding]; other site 1114970013886 active site 1114970013887 MgATP binding site [chemical binding]; other site 1114970013888 catalytic site [active] 1114970013889 metal binding site [ion binding]; metal-binding site 1114970013890 glycerol binding site [chemical binding]; other site 1114970013891 homotetramer interface [polypeptide binding]; other site 1114970013892 homodimer interface [polypeptide binding]; other site 1114970013893 protein IIAGlc interface [polypeptide binding]; other site 1114970013894 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1114970013895 Helix-turn-helix domains; Region: HTH; cl00088 1114970013896 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114970013897 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1114970013898 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1114970013899 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970013900 substrate binding pocket [chemical binding]; other site 1114970013901 membrane-bound complex binding site; other site 1114970013902 hinge residues; other site 1114970013903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970013904 dimer interface [polypeptide binding]; other site 1114970013905 conserved gate region; other site 1114970013906 putative PBP binding loops; other site 1114970013907 ABC-ATPase subunit interface; other site 1114970013908 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970013909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970013910 dimer interface [polypeptide binding]; other site 1114970013911 conserved gate region; other site 1114970013912 putative PBP binding loops; other site 1114970013913 ABC-ATPase subunit interface; other site 1114970013914 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970013915 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970013916 Walker A/P-loop; other site 1114970013917 ATP binding site [chemical binding]; other site 1114970013918 Q-loop/lid; other site 1114970013919 ABC transporter signature motif; other site 1114970013920 Walker B; other site 1114970013921 D-loop; other site 1114970013922 H-loop/switch region; other site 1114970013923 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1114970013924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970013925 dimer interface [polypeptide binding]; other site 1114970013926 phosphorylation site [posttranslational modification] 1114970013927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970013928 Mg2+ binding site [ion binding]; other site 1114970013929 G-X-G motif; other site 1114970013930 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970013931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970013932 active site 1114970013933 phosphorylation site [posttranslational modification] 1114970013934 intermolecular recognition site; other site 1114970013935 dimerization interface [polypeptide binding]; other site 1114970013936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970013937 Walker A motif; other site 1114970013938 ATP binding site [chemical binding]; other site 1114970013939 Walker B motif; other site 1114970013940 arginine finger; other site 1114970013941 Helix-turn-helix domains; Region: HTH; cl00088 1114970013942 GlpM protein; Region: GlpM; cl01212 1114970013943 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1114970013944 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1114970013945 NAD binding site [chemical binding]; other site 1114970013946 putative active site [active] 1114970013947 substrate binding site [chemical binding]; other site 1114970013948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970013949 transcriptional regulator; Provisional; Region: PRK10632 1114970013950 Helix-turn-helix domains; Region: HTH; cl00088 1114970013951 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970013952 putative effector binding pocket; other site 1114970013953 dimerization interface [polypeptide binding]; other site 1114970013954 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1114970013955 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1114970013956 putative aromatic amino acid binding site; other site 1114970013957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970013958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970013959 Walker A motif; other site 1114970013960 ATP binding site [chemical binding]; other site 1114970013961 Walker B motif; other site 1114970013962 arginine finger; other site 1114970013963 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1114970013964 lipoyl attachment site [posttranslational modification]; other site 1114970013965 glycine dehydrogenase; Provisional; Region: PRK05367 1114970013966 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1114970013967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970013968 tetramer interface [polypeptide binding]; other site 1114970013969 catalytic residue [active] 1114970013970 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1114970013971 tetramer interface [polypeptide binding]; other site 1114970013972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970013973 catalytic residue [active] 1114970013974 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1114970013975 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1114970013976 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1114970013977 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1114970013978 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114970013979 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1114970013980 DNA-binding site [nucleotide binding]; DNA binding site 1114970013981 RNA-binding motif; other site 1114970013982 RDD family; Region: RDD; cl00746 1114970013983 Quinolinate synthetase A protein; Region: NadA; cl00420 1114970013984 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1114970013985 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114970013986 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114970013987 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114970013988 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 1114970013989 Bacterial Ig-like domain; Region: Big_5; cl01012 1114970013990 Copper resistance protein D; Region: CopD; cl00563 1114970013991 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1114970013992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970013993 putative substrate translocation pore; other site 1114970013994 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1114970013995 Ligand Binding Site [chemical binding]; other site 1114970013996 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 1114970013997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970013998 FeS/SAM binding site; other site 1114970013999 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1114970014000 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1114970014001 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970014002 ligand binding site [chemical binding]; other site 1114970014003 translocation protein TolB; Provisional; Region: tolB; PRK00178 1114970014004 TolB amino-terminal domain; Region: TolB_N; cl00639 1114970014005 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1114970014006 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1114970014007 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1114970014008 TolA protein; Region: tolA_full; TIGR02794 1114970014009 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1114970014010 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1114970014011 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1114970014012 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114970014013 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114970014014 active site 1114970014015 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1114970014016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970014017 Walker A motif; other site 1114970014018 ATP binding site [chemical binding]; other site 1114970014019 Walker B motif; other site 1114970014020 arginine finger; other site 1114970014021 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1114970014022 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1114970014023 RuvA N terminal domain; Region: RuvA_N; pfam01330 1114970014024 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1114970014025 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1114970014026 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 1114970014027 active site 1114970014028 putative DNA-binding cleft [nucleotide binding]; other site 1114970014029 dimer interface [polypeptide binding]; other site 1114970014030 Transcriptional regulator; Region: Transcrip_reg; cl00361 1114970014031 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1114970014032 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1114970014033 dimer interface [polypeptide binding]; other site 1114970014034 anticodon binding site; other site 1114970014035 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 1114970014036 homodimer interface [polypeptide binding]; other site 1114970014037 motif 1; other site 1114970014038 active site 1114970014039 motif 2; other site 1114970014040 GAD domain; Region: GAD; pfam02938 1114970014041 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1114970014042 active site 1114970014043 motif 3; other site 1114970014044 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1114970014045 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1114970014046 Ribbon-helix-helix domain; Region: RHH_4; cl01775 1114970014047 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1114970014048 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1114970014049 dimerization interface [polypeptide binding]; other site 1114970014050 DPS ferroxidase diiron center [ion binding]; other site 1114970014051 ion pore; other site 1114970014052 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1114970014053 DNA-binding site [nucleotide binding]; DNA binding site 1114970014054 RNA-binding motif; other site 1114970014055 SlyX; Region: SlyX; cl01090 1114970014056 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1114970014057 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970014058 mechanosensitive channel MscS; Provisional; Region: PRK10334 1114970014059 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114970014060 Protein of unknown function (DUF520); Region: DUF520; cl00723 1114970014061 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 1114970014062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970014063 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1114970014064 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1114970014065 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970014066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970014067 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1114970014068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970014069 dimer interface [polypeptide binding]; other site 1114970014070 phosphorylation site [posttranslational modification] 1114970014071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014072 ATP binding site [chemical binding]; other site 1114970014073 Mg2+ binding site [ion binding]; other site 1114970014074 G-X-G motif; other site 1114970014075 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1114970014076 hypothetical protein; Provisional; Region: PRK08999 1114970014077 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1114970014078 active site 1114970014079 8-oxo-dGMP binding site [chemical binding]; other site 1114970014080 nudix motif; other site 1114970014081 metal binding site [ion binding]; metal-binding site 1114970014082 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1114970014083 thiamine phosphate binding site [chemical binding]; other site 1114970014084 active site 1114970014085 pyrophosphate binding site [ion binding]; other site 1114970014086 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1114970014087 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970014088 putative C-terminal domain interface [polypeptide binding]; other site 1114970014089 putative GSH binding site (G-site) [chemical binding]; other site 1114970014090 putative dimer interface [polypeptide binding]; other site 1114970014091 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1114970014092 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970014093 putative N-terminal domain interface [polypeptide binding]; other site 1114970014094 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1114970014095 heterotetramer interface [polypeptide binding]; other site 1114970014096 active site pocket [active] 1114970014097 cleavage site 1114970014098 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 1114970014099 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970014100 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 1114970014101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970014102 nucleotide binding region [chemical binding]; other site 1114970014103 ATP-binding site [chemical binding]; other site 1114970014104 SEC-C motif; Region: SEC-C; pfam02810 1114970014105 Protein of unknown function (DUF721); Region: DUF721; cl02324 1114970014106 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1114970014107 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970014108 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1114970014109 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1114970014110 Predicted deacetylase [General function prediction only]; Region: COG3233 1114970014111 putative active site [active] 1114970014112 putative Zn binding site [ion binding]; other site 1114970014113 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1114970014114 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1114970014115 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1114970014116 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1114970014117 putative active site [active] 1114970014118 putative substrate binding site [chemical binding]; other site 1114970014119 putative cosubstrate binding site; other site 1114970014120 catalytic site [active] 1114970014121 exonuclease I; Provisional; Region: sbcB; PRK11779 1114970014122 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1114970014123 active site 1114970014124 catalytic site [active] 1114970014125 substrate binding site [chemical binding]; other site 1114970014126 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1114970014127 RDD family; Region: RDD; cl00746 1114970014128 Integral membrane protein DUF95; Region: DUF95; cl00572 1114970014129 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1114970014130 MoxR-like ATPases [General function prediction only]; Region: COG0714 1114970014131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970014132 Walker A motif; other site 1114970014133 ATP binding site [chemical binding]; other site 1114970014134 Walker B motif; other site 1114970014135 arginine finger; other site 1114970014136 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1114970014137 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114970014138 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114970014139 PilZ domain; Region: PilZ; cl01260 1114970014140 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1114970014141 pyruvate kinase; Provisional; Region: PRK05826 1114970014142 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1114970014143 domain interfaces; other site 1114970014144 active site 1114970014145 hypothetical protein; Provisional; Region: PRK05713 1114970014146 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970014147 catalytic loop [active] 1114970014148 iron binding site [ion binding]; other site 1114970014149 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 1114970014150 FAD binding pocket [chemical binding]; other site 1114970014151 FAD binding motif [chemical binding]; other site 1114970014152 phosphate binding motif [ion binding]; other site 1114970014153 beta-alpha-beta structure motif; other site 1114970014154 NAD binding pocket [chemical binding]; other site 1114970014155 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970014156 metal binding site [ion binding]; metal-binding site 1114970014157 active site 1114970014158 I-site; other site 1114970014159 putative fumarate hydratase; Provisional; Region: PRK15392 1114970014160 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 1114970014161 Fumarase C-terminus; Region: Fumerase_C; cl00795 1114970014162 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1114970014163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970014164 dimer interface [polypeptide binding]; other site 1114970014165 phosphorylation site [posttranslational modification] 1114970014166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014167 ATP binding site [chemical binding]; other site 1114970014168 Mg2+ binding site [ion binding]; other site 1114970014169 G-X-G motif; other site 1114970014170 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970014171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014172 active site 1114970014173 phosphorylation site [posttranslational modification] 1114970014174 intermolecular recognition site; other site 1114970014175 dimerization interface [polypeptide binding]; other site 1114970014176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970014177 Walker A motif; other site 1114970014178 ATP binding site [chemical binding]; other site 1114970014179 Walker B motif; other site 1114970014180 arginine finger; other site 1114970014181 Helix-turn-helix domains; Region: HTH; cl00088 1114970014182 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1114970014183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970014184 putative substrate translocation pore; other site 1114970014185 Flavin Reductases; Region: FlaRed; cl00801 1114970014186 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114970014187 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1114970014188 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970014189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970014190 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970014191 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970014192 Walker A/P-loop; other site 1114970014193 ATP binding site [chemical binding]; other site 1114970014194 Q-loop/lid; other site 1114970014195 ABC transporter signature motif; other site 1114970014196 Walker B; other site 1114970014197 D-loop; other site 1114970014198 H-loop/switch region; other site 1114970014199 TOBE domain; Region: TOBE_2; cl01440 1114970014200 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970014201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970014202 dimer interface [polypeptide binding]; other site 1114970014203 conserved gate region; other site 1114970014204 putative PBP binding loops; other site 1114970014205 ABC-ATPase subunit interface; other site 1114970014206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970014207 dimer interface [polypeptide binding]; other site 1114970014208 putative PBP binding loops; other site 1114970014209 ABC-ATPase subunit interface; other site 1114970014210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970014211 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114970014212 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970014213 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 1114970014214 NAD(P) binding site [chemical binding]; other site 1114970014215 catalytic residues [active] 1114970014216 catalytic residues [active] 1114970014217 hypothetical protein; Provisional; Region: PRK07524 1114970014218 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114970014219 PYR/PP interface [polypeptide binding]; other site 1114970014220 dimer interface [polypeptide binding]; other site 1114970014221 TPP binding site [chemical binding]; other site 1114970014222 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1114970014223 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1114970014224 TPP-binding site [chemical binding]; other site 1114970014225 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970014226 Helix-turn-helix domains; Region: HTH; cl00088 1114970014227 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970014228 substrate binding pocket [chemical binding]; other site 1114970014229 dimerization interface [polypeptide binding]; other site 1114970014230 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1114970014231 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970014232 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1114970014233 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1114970014234 THF binding site; other site 1114970014235 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1114970014236 substrate binding site [chemical binding]; other site 1114970014237 THF binding site; other site 1114970014238 zinc-binding site [ion binding]; other site 1114970014239 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1114970014240 Helix-turn-helix domains; Region: HTH; cl00088 1114970014241 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1114970014242 putative dimerization interface [polypeptide binding]; other site 1114970014243 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114970014244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970014245 Coenzyme A binding pocket [chemical binding]; other site 1114970014246 LysE type translocator; Region: LysE; cl00565 1114970014247 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1114970014248 nudix motif; other site 1114970014249 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1114970014250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014251 active site 1114970014252 phosphorylation site [posttranslational modification] 1114970014253 intermolecular recognition site; other site 1114970014254 dimerization interface [polypeptide binding]; other site 1114970014255 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114970014256 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970014257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014258 active site 1114970014259 phosphorylation site [posttranslational modification] 1114970014260 intermolecular recognition site; other site 1114970014261 dimerization interface [polypeptide binding]; other site 1114970014262 hypothetical protein; Provisional; Region: PRK13560 1114970014263 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970014264 metal binding site [ion binding]; metal-binding site 1114970014265 active site 1114970014266 I-site; other site 1114970014267 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970014268 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970014269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014270 active site 1114970014271 phosphorylation site [posttranslational modification] 1114970014272 intermolecular recognition site; other site 1114970014273 dimerization interface [polypeptide binding]; other site 1114970014274 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970014275 metal binding site [ion binding]; metal-binding site 1114970014276 active site 1114970014277 I-site; other site 1114970014278 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970014279 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1114970014280 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 1114970014281 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1114970014282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014283 ATP binding site [chemical binding]; other site 1114970014284 G-X-G motif; other site 1114970014285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014286 active site 1114970014287 phosphorylation site [posttranslational modification] 1114970014288 intermolecular recognition site; other site 1114970014289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970014290 dimerization interface [polypeptide binding]; other site 1114970014291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970014292 dimer interface [polypeptide binding]; other site 1114970014293 phosphorylation site [posttranslational modification] 1114970014294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014295 ATP binding site [chemical binding]; other site 1114970014296 Mg2+ binding site [ion binding]; other site 1114970014297 G-X-G motif; other site 1114970014298 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1114970014299 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1114970014300 active site 1114970014301 FMN binding site [chemical binding]; other site 1114970014302 substrate binding site [chemical binding]; other site 1114970014303 3Fe-4S cluster binding site [ion binding]; other site 1114970014304 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1114970014305 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1114970014306 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1114970014307 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114970014308 Spore germination protein; Region: Spore_permease; cl15802 1114970014309 Transposase IS200 like; Region: Y1_Tnp; cl00848 1114970014310 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1114970014311 Transglycosylase; Region: Transgly; cl07896 1114970014312 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970014313 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1114970014314 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1114970014315 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1114970014316 Helix-turn-helix domains; Region: HTH; cl00088 1114970014317 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1114970014318 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1114970014319 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1114970014320 FAD binding pocket [chemical binding]; other site 1114970014321 FAD binding motif [chemical binding]; other site 1114970014322 phosphate binding motif [ion binding]; other site 1114970014323 NAD binding pocket [chemical binding]; other site 1114970014324 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1114970014325 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1114970014326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970014327 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970014328 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1114970014329 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1114970014330 Trp docking motif [polypeptide binding]; other site 1114970014331 putative active site [active] 1114970014332 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 1114970014333 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 1114970014334 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1114970014335 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1114970014336 trimer interface [polypeptide binding]; other site 1114970014337 putative metal binding site [ion binding]; other site 1114970014338 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1114970014339 putative active site [active] 1114970014340 putative CoA binding site [chemical binding]; other site 1114970014341 nudix motif; other site 1114970014342 metal binding site [ion binding]; metal-binding site 1114970014343 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1114970014344 nudix motif; other site 1114970014345 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1114970014346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1114970014347 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1114970014348 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1114970014349 dimerization interface [polypeptide binding]; other site 1114970014350 ATP binding site [chemical binding]; other site 1114970014351 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1114970014352 dimerization interface [polypeptide binding]; other site 1114970014353 ATP binding site [chemical binding]; other site 1114970014354 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1114970014355 putative active site [active] 1114970014356 catalytic triad [active] 1114970014357 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1114970014358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970014359 substrate binding pocket [chemical binding]; other site 1114970014360 membrane-bound complex binding site; other site 1114970014361 hinge residues; other site 1114970014362 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1114970014363 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970014364 catalytic residue [active] 1114970014365 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 1114970014366 active site 1114970014367 hydrophilic channel; other site 1114970014368 dimerization interface [polypeptide binding]; other site 1114970014369 catalytic residues [active] 1114970014370 active site lid [active] 1114970014371 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1114970014372 Recombination protein O N terminal; Region: RecO_N; cl15812 1114970014373 Recombination protein O C terminal; Region: RecO_C; pfam02565 1114970014374 GTPase Era; Reviewed; Region: era; PRK00089 1114970014375 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1114970014376 G1 box; other site 1114970014377 GTP/Mg2+ binding site [chemical binding]; other site 1114970014378 Switch I region; other site 1114970014379 G2 box; other site 1114970014380 Switch II region; other site 1114970014381 G3 box; other site 1114970014382 G4 box; other site 1114970014383 G5 box; other site 1114970014384 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1114970014385 ribonuclease III; Reviewed; Region: rnc; PRK00102 1114970014386 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1114970014387 dimerization interface [polypeptide binding]; other site 1114970014388 active site 1114970014389 metal binding site [ion binding]; metal-binding site 1114970014390 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1114970014391 dsRNA binding site [nucleotide binding]; other site 1114970014392 signal peptidase I; Provisional; Region: PRK10861 1114970014393 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114970014394 Catalytic site [active] 1114970014395 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114970014396 GTP-binding protein LepA; Provisional; Region: PRK05433 1114970014397 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1114970014398 G1 box; other site 1114970014399 putative GEF interaction site [polypeptide binding]; other site 1114970014400 GTP/Mg2+ binding site [chemical binding]; other site 1114970014401 Switch I region; other site 1114970014402 G2 box; other site 1114970014403 G3 box; other site 1114970014404 Switch II region; other site 1114970014405 G4 box; other site 1114970014406 G5 box; other site 1114970014407 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1114970014408 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1114970014409 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1114970014410 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1114970014411 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1114970014412 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1114970014413 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1114970014414 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1114970014415 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1114970014416 interface (dimer of trimers) [polypeptide binding]; other site 1114970014417 Substrate-binding/catalytic site; other site 1114970014418 Zn-binding sites [ion binding]; other site 1114970014419 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 1114970014420 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1114970014421 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1114970014422 HIGH motif; other site 1114970014423 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114970014424 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1114970014425 active site 1114970014426 KMSKS motif; other site 1114970014427 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1114970014428 tRNA binding surface [nucleotide binding]; other site 1114970014429 anticodon binding site; other site 1114970014430 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1114970014431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970014432 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1114970014433 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114970014434 IHF - DNA interface [nucleotide binding]; other site 1114970014435 IHF dimer interface [polypeptide binding]; other site 1114970014436 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1114970014437 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 1114970014438 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970014439 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1114970014440 C-terminal domain interface [polypeptide binding]; other site 1114970014441 GSH binding site (G-site) [chemical binding]; other site 1114970014442 dimer interface [polypeptide binding]; other site 1114970014443 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1114970014444 N-terminal domain interface [polypeptide binding]; other site 1114970014445 substrate binding pocket (H-site) [chemical binding]; other site 1114970014446 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1114970014447 GIY-YIG motif/motif A; other site 1114970014448 putative active site [active] 1114970014449 putative metal binding site [ion binding]; other site 1114970014450 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970014451 cyanate transporter; Region: CynX; TIGR00896 1114970014452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970014453 putative substrate translocation pore; other site 1114970014454 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970014455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970014456 DNA-binding site [nucleotide binding]; DNA binding site 1114970014457 FCD domain; Region: FCD; cl11656 1114970014458 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1114970014459 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970014460 non-specific DNA binding site [nucleotide binding]; other site 1114970014461 salt bridge; other site 1114970014462 sequence-specific DNA binding site [nucleotide binding]; other site 1114970014463 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970014464 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970014465 Walker A/P-loop; other site 1114970014466 ATP binding site [chemical binding]; other site 1114970014467 Q-loop/lid; other site 1114970014468 ABC transporter signature motif; other site 1114970014469 Walker B; other site 1114970014470 D-loop; other site 1114970014471 H-loop/switch region; other site 1114970014472 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970014473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970014474 dimer interface [polypeptide binding]; other site 1114970014475 conserved gate region; other site 1114970014476 putative PBP binding loops; other site 1114970014477 ABC-ATPase subunit interface; other site 1114970014478 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1114970014479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970014480 conserved gate region; other site 1114970014481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1114970014482 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970014483 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1114970014484 substrate binding pocket [chemical binding]; other site 1114970014485 membrane-bound complex binding site; other site 1114970014486 hinge residues; other site 1114970014487 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1114970014488 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970014489 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 1114970014490 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114970014491 ATP binding site [chemical binding]; other site 1114970014492 Mg++ binding site [ion binding]; other site 1114970014493 motif III; other site 1114970014494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970014495 nucleotide binding region [chemical binding]; other site 1114970014496 ATP-binding site [chemical binding]; other site 1114970014497 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1114970014498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970014499 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970014500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970014501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1114970014502 YheO-like PAS domain; Region: PAS_6; pfam08348 1114970014503 Helix-turn-helix domains; Region: HTH; cl00088 1114970014504 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1114970014505 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970014506 substrate binding pocket [chemical binding]; other site 1114970014507 membrane-bound complex binding site; other site 1114970014508 hinge residues; other site 1114970014509 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1114970014510 MoaE homodimer interface [polypeptide binding]; other site 1114970014511 MoaD interaction [polypeptide binding]; other site 1114970014512 active site residues [active] 1114970014513 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1114970014514 MoaE interaction surface [polypeptide binding]; other site 1114970014515 MoeB interaction surface [polypeptide binding]; other site 1114970014516 thiocarboxylated glycine; other site 1114970014517 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1114970014518 trimer interface [polypeptide binding]; other site 1114970014519 dimer interface [polypeptide binding]; other site 1114970014520 putative active site [active] 1114970014521 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1114970014522 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1114970014523 putative active site [active] 1114970014524 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970014525 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1114970014526 NodB motif; other site 1114970014527 active site 1114970014528 catalytic site [active] 1114970014529 metal binding site [ion binding]; metal-binding site 1114970014530 Protein of unknown function (DUF328); Region: DUF328; cl01143 1114970014531 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1114970014532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970014533 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114970014534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970014535 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114970014536 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970014537 PilZ domain; Region: PilZ; cl01260 1114970014538 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970014539 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1114970014540 Right handed beta helix region; Region: Beta_helix; pfam13229 1114970014541 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1114970014542 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 1114970014543 active site 1114970014544 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1114970014545 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 1114970014546 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1114970014547 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1114970014548 Substrate binding site; other site 1114970014549 Cupin domain; Region: Cupin_2; cl09118 1114970014550 short chain dehydrogenase; Provisional; Region: PRK05693 1114970014551 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1114970014552 NADP binding site [chemical binding]; other site 1114970014553 active site 1114970014554 steroid binding site; other site 1114970014555 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1114970014556 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970014557 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970014558 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 1114970014559 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1114970014560 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1114970014561 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970014562 transcriptional regulator; Provisional; Region: PRK10632 1114970014563 Helix-turn-helix domains; Region: HTH; cl00088 1114970014564 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970014565 putative effector binding pocket; other site 1114970014566 dimerization interface [polypeptide binding]; other site 1114970014567 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1114970014568 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970014569 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970014570 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1114970014571 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1114970014572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014573 active site 1114970014574 phosphorylation site [posttranslational modification] 1114970014575 intermolecular recognition site; other site 1114970014576 dimerization interface [polypeptide binding]; other site 1114970014577 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970014578 DNA binding site [nucleotide binding] 1114970014579 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1114970014580 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970014581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970014582 dimer interface [polypeptide binding]; other site 1114970014583 phosphorylation site [posttranslational modification] 1114970014584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014585 ATP binding site [chemical binding]; other site 1114970014586 Mg2+ binding site [ion binding]; other site 1114970014587 G-X-G motif; other site 1114970014588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970014589 metal binding site [ion binding]; metal-binding site 1114970014590 active site 1114970014591 I-site; other site 1114970014592 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 1114970014593 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1114970014594 cell division protein FtsZ; Validated; Region: PRK09330 1114970014595 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1114970014596 nucleotide binding site [chemical binding]; other site 1114970014597 SulA interaction site; other site 1114970014598 cell division protein FtsA; Region: ftsA; TIGR01174 1114970014599 Cell division protein FtsA; Region: FtsA; cl11496 1114970014600 Cell division protein FtsA; Region: FtsA; cl11496 1114970014601 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1114970014602 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1114970014603 Cell division protein FtsQ; Region: FtsQ; pfam03799 1114970014604 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1114970014605 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1114970014606 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970014607 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1114970014608 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114970014609 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114970014610 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114970014611 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1114970014612 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1114970014613 active site 1114970014614 homodimer interface [polypeptide binding]; other site 1114970014615 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1114970014616 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 1114970014617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970014618 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114970014619 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1114970014620 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1114970014621 Mg++ binding site [ion binding]; other site 1114970014622 putative catalytic motif [active] 1114970014623 putative substrate binding site [chemical binding]; other site 1114970014624 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114970014625 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1114970014626 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114970014627 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114970014628 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1114970014629 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114970014630 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114970014631 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114970014632 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1114970014633 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114970014634 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970014635 Septum formation initiator; Region: DivIC; cl11433 1114970014636 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1114970014637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970014638 MraZ protein; Region: MraZ; pfam02381 1114970014639 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1114970014640 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1114970014641 LppC putative lipoprotein; Region: LppC; pfam04348 1114970014642 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1114970014643 putative ligand binding site [chemical binding]; other site 1114970014644 Restriction endonuclease; Region: Mrr_cat; cl00516 1114970014645 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1114970014646 dimer interface [polypeptide binding]; other site 1114970014647 active site 1114970014648 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1114970014649 BON domain; Region: BON; cl02771 1114970014650 BON domain; Region: BON; cl02771 1114970014651 Stringent starvation protein B; Region: SspB; cl01120 1114970014652 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1114970014653 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1114970014654 C-terminal domain interface [polypeptide binding]; other site 1114970014655 putative GSH binding site (G-site) [chemical binding]; other site 1114970014656 dimer interface [polypeptide binding]; other site 1114970014657 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1114970014658 dimer interface [polypeptide binding]; other site 1114970014659 N-terminal domain interface [polypeptide binding]; other site 1114970014660 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 1114970014661 cytochrome b; Provisional; Region: CYTB; MTH00145 1114970014662 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1114970014663 Qi binding site; other site 1114970014664 intrachain domain interface; other site 1114970014665 interchain domain interface [polypeptide binding]; other site 1114970014666 heme bH binding site [chemical binding]; other site 1114970014667 heme bL binding site [chemical binding]; other site 1114970014668 Qo binding site; other site 1114970014669 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1114970014670 interchain domain interface [polypeptide binding]; other site 1114970014671 intrachain domain interface; other site 1114970014672 Qi binding site; other site 1114970014673 Qo binding site; other site 1114970014674 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1114970014675 [2Fe-2S] cluster binding site [ion binding]; other site 1114970014676 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 1114970014677 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1114970014678 23S rRNA interface [nucleotide binding]; other site 1114970014679 L3 interface [polypeptide binding]; other site 1114970014680 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1114970014681 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970014682 active site 1114970014683 catalytic tetrad [active] 1114970014684 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970014685 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970014686 active site 1114970014687 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970014688 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1114970014689 conserved cys residue [active] 1114970014690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970014691 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970014692 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1114970014693 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 1114970014694 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1114970014695 active site 1114970014696 HIGH motif; other site 1114970014697 dimer interface [polypeptide binding]; other site 1114970014698 KMSKS motif; other site 1114970014699 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1114970014700 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 1114970014701 hypothetical protein; Provisional; Region: PRK07482 1114970014702 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970014703 inhibitor-cofactor binding pocket; inhibition site 1114970014704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970014705 catalytic residue [active] 1114970014706 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970014707 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1114970014708 tetramerization interface [polypeptide binding]; other site 1114970014709 NAD(P) binding site [chemical binding]; other site 1114970014710 catalytic residues [active] 1114970014711 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970014712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970014713 putative DNA binding site [nucleotide binding]; other site 1114970014714 putative Zn2+ binding site [ion binding]; other site 1114970014715 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970014716 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 1114970014717 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 1114970014718 putative active site [active] 1114970014719 Zn binding site [ion binding]; other site 1114970014720 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 1114970014721 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1114970014722 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1114970014723 active site 1114970014724 ectoine utilization protein EutC; Validated; Region: PRK08291 1114970014725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970014726 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1114970014727 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1114970014728 tetramer interface [polypeptide binding]; other site 1114970014729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970014730 catalytic residue [active] 1114970014731 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970014732 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970014733 DNA-binding site [nucleotide binding]; DNA binding site 1114970014734 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970014735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970014736 homodimer interface [polypeptide binding]; other site 1114970014737 catalytic residue [active] 1114970014738 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 1114970014739 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970014740 substrate binding pocket [chemical binding]; other site 1114970014741 membrane-bound complex binding site; other site 1114970014742 hinge residues; other site 1114970014743 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970014744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970014745 dimer interface [polypeptide binding]; other site 1114970014746 conserved gate region; other site 1114970014747 putative PBP binding loops; other site 1114970014748 ABC-ATPase subunit interface; other site 1114970014749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970014750 dimer interface [polypeptide binding]; other site 1114970014751 conserved gate region; other site 1114970014752 putative PBP binding loops; other site 1114970014753 ABC-ATPase subunit interface; other site 1114970014754 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 1114970014755 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970014756 Walker A/P-loop; other site 1114970014757 ATP binding site [chemical binding]; other site 1114970014758 Q-loop/lid; other site 1114970014759 ABC transporter signature motif; other site 1114970014760 Walker B; other site 1114970014761 D-loop; other site 1114970014762 H-loop/switch region; other site 1114970014763 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970014764 ligand binding site [chemical binding]; other site 1114970014765 acetylornithine aminotransferase; Provisional; Region: PRK02627 1114970014766 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970014767 inhibitor-cofactor binding pocket; inhibition site 1114970014768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970014769 catalytic residue [active] 1114970014770 Helix-turn-helix domains; Region: HTH; cl00088 1114970014771 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970014772 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 1114970014773 putative effector binding pocket; other site 1114970014774 putative dimerization interface [polypeptide binding]; other site 1114970014775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970014776 PAS fold; Region: PAS_3; pfam08447 1114970014777 putative active site [active] 1114970014778 heme pocket [chemical binding]; other site 1114970014779 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970014780 metal binding site [ion binding]; metal-binding site 1114970014781 active site 1114970014782 I-site; other site 1114970014783 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970014784 UbiA prenyltransferase family; Region: UbiA; cl00337 1114970014785 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1114970014786 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1114970014787 Subunit I/III interface [polypeptide binding]; other site 1114970014788 Subunit III/IV interface [polypeptide binding]; other site 1114970014789 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1114970014790 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1114970014791 D-pathway; other site 1114970014792 Putative ubiquinol binding site [chemical binding]; other site 1114970014793 Low-spin heme (heme b) binding site [chemical binding]; other site 1114970014794 Putative water exit pathway; other site 1114970014795 Binuclear center (heme o3/CuB) [ion binding]; other site 1114970014796 K-pathway; other site 1114970014797 Putative proton exit pathway; other site 1114970014798 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1114970014799 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114970014800 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1114970014801 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1114970014802 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1114970014803 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1114970014804 heme-binding site [chemical binding]; other site 1114970014805 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1114970014806 FAD binding pocket [chemical binding]; other site 1114970014807 FAD binding motif [chemical binding]; other site 1114970014808 phosphate binding motif [ion binding]; other site 1114970014809 beta-alpha-beta structure motif; other site 1114970014810 NAD binding pocket [chemical binding]; other site 1114970014811 Heme binding pocket [chemical binding]; other site 1114970014812 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1114970014813 GAF domain; Region: GAF; cl15785 1114970014814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970014815 Walker A motif; other site 1114970014816 ATP binding site [chemical binding]; other site 1114970014817 Walker B motif; other site 1114970014818 Helix-turn-helix domains; Region: HTH; cl00088 1114970014819 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1114970014820 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970014821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014822 active site 1114970014823 phosphorylation site [posttranslational modification] 1114970014824 intermolecular recognition site; other site 1114970014825 dimerization interface [polypeptide binding]; other site 1114970014826 Flagellin N-methylase; Region: FliB; cl00497 1114970014827 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1114970014828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970014829 EamA-like transporter family; Region: EamA; cl01037 1114970014830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970014831 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970014832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970014833 RNA polymerase sigma factor; Provisional; Region: PRK12528 1114970014834 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970014835 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970014836 fec operon regulator FecR; Reviewed; Region: PRK09774 1114970014837 FecR protein; Region: FecR; pfam04773 1114970014838 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1114970014839 Secretin and TonB N terminus short domain; Region: STN; cl06624 1114970014840 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970014841 N-terminal plug; other site 1114970014842 ligand-binding site [chemical binding]; other site 1114970014843 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250 1114970014844 30S subunit binding site; other site 1114970014845 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1114970014846 Phosphate-starvation-inducible E; Region: PsiE; cl01264 1114970014847 YebG protein; Region: YebG; cl01217 1114970014848 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970014849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970014850 DNA-binding site [nucleotide binding]; DNA binding site 1114970014851 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970014852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970014853 homodimer interface [polypeptide binding]; other site 1114970014854 catalytic residue [active] 1114970014855 Benzoate membrane transport protein; Region: BenE; pfam03594 1114970014856 benzoate transporter; Region: benE; TIGR00843 1114970014857 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970014858 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114970014859 homotrimer interaction site [polypeptide binding]; other site 1114970014860 putative active site [active] 1114970014861 threonine synthase; Validated; Region: PRK06260 1114970014862 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1114970014863 homodimer interface [polypeptide binding]; other site 1114970014864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970014865 catalytic residue [active] 1114970014866 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1114970014867 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1114970014868 dimer interface [polypeptide binding]; other site 1114970014869 active site 1114970014870 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1114970014871 folate binding site [chemical binding]; other site 1114970014872 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1114970014873 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1114970014874 NAD binding site [chemical binding]; other site 1114970014875 Phe binding site; other site 1114970014876 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1114970014877 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1114970014878 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1114970014879 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114970014880 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1114970014881 dimer interface [polypeptide binding]; other site 1114970014882 N-terminal domain interface [polypeptide binding]; other site 1114970014883 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1114970014884 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1114970014885 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1114970014886 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970014887 Cupin domain; Region: Cupin_2; cl09118 1114970014888 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970014889 Helix-turn-helix domains; Region: HTH; cl00088 1114970014890 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970014891 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1114970014892 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970014893 DNA binding residues [nucleotide binding] 1114970014894 dimerization interface [polypeptide binding]; other site 1114970014895 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1114970014896 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1114970014897 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1114970014898 S-type Pyocin; Region: Pyocin_S; pfam06958 1114970014899 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114970014900 amidase catalytic site [active] 1114970014901 Zn binding residues [ion binding]; other site 1114970014902 substrate binding site [chemical binding]; other site 1114970014903 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1114970014904 homodimer interface [polypeptide binding]; other site 1114970014905 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114970014906 NAD binding site [chemical binding]; other site 1114970014907 active site 1114970014908 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970014909 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1114970014910 intersubunit interface [polypeptide binding]; other site 1114970014911 active site 1114970014912 Zn2+ binding site [ion binding]; other site 1114970014913 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970014914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970014915 PAS domain; Region: PAS_9; pfam13426 1114970014916 putative active site [active] 1114970014917 heme pocket [chemical binding]; other site 1114970014918 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114970014919 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1114970014920 DNA binding residues [nucleotide binding] 1114970014921 B12 binding domain; Region: B12-binding_2; cl03653 1114970014922 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114970014923 dihydromonapterin reductase; Provisional; Region: PRK06483 1114970014924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970014925 NAD(P) binding site [chemical binding]; other site 1114970014926 active site 1114970014927 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1114970014928 homodecamer interface [polypeptide binding]; other site 1114970014929 GTP cyclohydrolase I; Provisional; Region: PLN03044 1114970014930 active site 1114970014931 putative catalytic site residues [active] 1114970014932 zinc binding site [ion binding]; other site 1114970014933 GTP-CH-I/GFRP interaction surface; other site 1114970014934 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1114970014935 active site 1114970014936 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 1114970014937 HopJ type III effector protein; Region: HopJ; pfam08888 1114970014938 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1114970014939 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970014940 inhibitor-cofactor binding pocket; inhibition site 1114970014941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970014942 catalytic residue [active] 1114970014943 thioredoxin reductase; Provisional; Region: PRK10262 1114970014944 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970014945 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1114970014946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970014947 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1114970014948 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1114970014949 putative active site [active] 1114970014950 putative FMN binding site [chemical binding]; other site 1114970014951 putative substrate binding site [chemical binding]; other site 1114970014952 putative catalytic residue [active] 1114970014953 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1114970014954 catalytic residues [active] 1114970014955 dimer interface [polypeptide binding]; other site 1114970014956 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1114970014957 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 1114970014958 phosphate acetyltransferase; Reviewed; Region: PRK05632 1114970014959 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970014960 DRTGG domain; Region: DRTGG; cl12147 1114970014961 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1114970014962 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114970014963 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1114970014964 putative acyl-acceptor binding pocket; other site 1114970014965 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1114970014966 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1114970014967 CysD dimerization site [polypeptide binding]; other site 1114970014968 G1 box; other site 1114970014969 putative GEF interaction site [polypeptide binding]; other site 1114970014970 GTP/Mg2+ binding site [chemical binding]; other site 1114970014971 Switch I region; other site 1114970014972 G2 box; other site 1114970014973 G3 box; other site 1114970014974 Switch II region; other site 1114970014975 G4 box; other site 1114970014976 G5 box; other site 1114970014977 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1114970014978 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1114970014979 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 1114970014980 ligand-binding site [chemical binding]; other site 1114970014981 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1114970014982 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1114970014983 Active Sites [active] 1114970014984 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1114970014985 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1114970014986 serine endoprotease; Provisional; Region: PRK10898 1114970014987 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1114970014988 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114970014989 protein binding site [polypeptide binding]; other site 1114970014990 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1114970014991 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970014992 N-terminal plug; other site 1114970014993 ligand-binding site [chemical binding]; other site 1114970014994 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1114970014995 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1114970014996 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1114970014997 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1114970014998 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 1114970014999 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970015000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970015001 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1114970015002 putative transporter; Provisional; Region: PRK11660 1114970015003 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114970015004 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114970015005 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1114970015006 Cupin domain; Region: Cupin_2; cl09118 1114970015007 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970015008 active site 1114970015009 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970015010 active site 1114970015011 uracil-xanthine permease; Region: ncs2; TIGR00801 1114970015012 ferrochelatase; Reviewed; Region: hemH; PRK00035 1114970015013 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1114970015014 C-terminal domain interface [polypeptide binding]; other site 1114970015015 active site 1114970015016 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1114970015017 active site 1114970015018 N-terminal domain interface [polypeptide binding]; other site 1114970015019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970015020 TIGR01777 family protein; Region: yfcH 1114970015021 NAD(P) binding site [chemical binding]; other site 1114970015022 active site 1114970015023 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1114970015024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970015025 Protein of unknown function (DUF523); Region: DUF523; cl00733 1114970015026 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1114970015027 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1114970015028 DNA binding residues [nucleotide binding] 1114970015029 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114970015030 B12 binding domain; Region: B12-binding_2; cl03653 1114970015031 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1114970015032 DNA photolyase; Region: DNA_photolyase; pfam00875 1114970015033 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1114970015034 classical (c) SDRs; Region: SDR_c; cd05233 1114970015035 NAD(P) binding site [chemical binding]; other site 1114970015036 active site 1114970015037 Flagellin N-methylase; Region: FliB; cl00497 1114970015038 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1114970015039 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114970015040 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1114970015041 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1114970015042 ATP binding site [chemical binding]; other site 1114970015043 substrate interface [chemical binding]; other site 1114970015044 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1114970015045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970015046 S-adenosylmethionine binding site [chemical binding]; other site 1114970015047 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1114970015048 RF-1 domain; Region: RF-1; cl02875 1114970015049 RF-1 domain; Region: RF-1; cl02875 1114970015050 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1114970015051 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1114970015052 tRNA; other site 1114970015053 putative tRNA binding site [nucleotide binding]; other site 1114970015054 putative NADP binding site [chemical binding]; other site 1114970015055 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1114970015056 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1114970015057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970015058 binding surface 1114970015059 TPR motif; other site 1114970015060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970015061 binding surface 1114970015062 TPR motif; other site 1114970015063 TPR repeat; Region: TPR_11; pfam13414 1114970015064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970015065 binding surface 1114970015066 TPR motif; other site 1114970015067 TPR repeat; Region: TPR_11; pfam13414 1114970015068 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1114970015069 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1114970015070 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1114970015071 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1114970015072 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1114970015073 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1114970015074 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970015075 active site 1114970015076 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1114970015077 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1114970015078 5S rRNA interface [nucleotide binding]; other site 1114970015079 CTC domain interface [polypeptide binding]; other site 1114970015080 L16 interface [polypeptide binding]; other site 1114970015081 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1114970015082 putative active site [active] 1114970015083 catalytic residue [active] 1114970015084 GTP-binding protein YchF; Reviewed; Region: PRK09601 1114970015085 YchF GTPase; Region: YchF; cd01900 1114970015086 G1 box; other site 1114970015087 GTP/Mg2+ binding site [chemical binding]; other site 1114970015088 Switch I region; other site 1114970015089 G2 box; other site 1114970015090 Switch II region; other site 1114970015091 G3 box; other site 1114970015092 G4 box; other site 1114970015093 G5 box; other site 1114970015094 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1114970015095 Cytochrome c; Region: Cytochrom_C; cl11414 1114970015096 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1114970015097 Cache domain; Region: Cache_1; pfam02743 1114970015098 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 1114970015099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970015100 dimerization interface [polypeptide binding]; other site 1114970015101 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970015102 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970015103 dimer interface [polypeptide binding]; other site 1114970015104 putative CheW interface [polypeptide binding]; other site 1114970015105 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1114970015106 mannose binding site [chemical binding]; other site 1114970015107 dimerization interface [polypeptide binding]; other site 1114970015108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970015109 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970015110 putative substrate translocation pore; other site 1114970015111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970015112 dimerization interface [polypeptide binding]; other site 1114970015113 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970015114 dimer interface [polypeptide binding]; other site 1114970015115 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1114970015116 putative CheW interface [polypeptide binding]; other site 1114970015117 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 1114970015118 Fic family protein [Function unknown]; Region: COG3177 1114970015119 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1114970015120 Fic/DOC family; Region: Fic; cl00960 1114970015121 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1114970015122 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1114970015123 PAS domain; Region: PAS_9; pfam13426 1114970015124 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970015125 putative active site [active] 1114970015126 heme pocket [chemical binding]; other site 1114970015127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970015128 PAS domain; Region: PAS_9; pfam13426 1114970015129 putative active site [active] 1114970015130 heme pocket [chemical binding]; other site 1114970015131 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970015132 dimer interface [polypeptide binding]; other site 1114970015133 putative CheW interface [polypeptide binding]; other site 1114970015134 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1114970015135 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1114970015136 active site clefts [active] 1114970015137 zinc binding site [ion binding]; other site 1114970015138 dimer interface [polypeptide binding]; other site 1114970015139 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1114970015140 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970015141 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1114970015142 mce related protein; Region: MCE; pfam02470 1114970015143 mce related protein; Region: MCE; pfam02470 1114970015144 mce related protein; Region: MCE; pfam02470 1114970015145 mce related protein; Region: MCE; pfam02470 1114970015146 mce related protein; Region: MCE; pfam02470 1114970015147 mce related protein; Region: MCE; pfam02470 1114970015148 Paraquat-inducible protein A; Region: PqiA; pfam04403 1114970015149 Paraquat-inducible protein A; Region: PqiA; pfam04403 1114970015150 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1114970015151 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1114970015152 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1114970015153 Moco binding site; other site 1114970015154 metal coordination site [ion binding]; other site 1114970015155 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1114970015156 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1114970015157 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1114970015158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970015159 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1114970015160 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1114970015161 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1114970015162 putative valine binding site [chemical binding]; other site 1114970015163 dimer interface [polypeptide binding]; other site 1114970015164 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1114970015165 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 1114970015166 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114970015167 PYR/PP interface [polypeptide binding]; other site 1114970015168 dimer interface [polypeptide binding]; other site 1114970015169 TPP binding site [chemical binding]; other site 1114970015170 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1114970015171 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1114970015172 TPP-binding site [chemical binding]; other site 1114970015173 dimer interface [polypeptide binding]; other site 1114970015174 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1114970015175 tRNA pseudouridine synthase C; Region: DUF446; cl01187 1114970015176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970015177 TPR motif; other site 1114970015178 binding surface 1114970015179 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1114970015180 Transglycosylase; Region: Transgly; cl07896 1114970015181 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970015182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1114970015183 AAA domain; Region: AAA_33; pfam13671 1114970015184 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1114970015185 ATP-binding site [chemical binding]; other site 1114970015186 Gluconate-6-phosphate binding site [chemical binding]; other site 1114970015187 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1114970015188 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1114970015189 TfoX N-terminal domain; Region: TfoX_N; cl01167 1114970015190 Protein of unknown function, DUF399; Region: DUF399; cl01139 1114970015191 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1114970015192 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114970015193 Walker A/P-loop; other site 1114970015194 ATP binding site [chemical binding]; other site 1114970015195 Q-loop/lid; other site 1114970015196 ABC transporter signature motif; other site 1114970015197 Walker B; other site 1114970015198 D-loop; other site 1114970015199 H-loop/switch region; other site 1114970015200 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114970015201 ABC-ATPase subunit interface; other site 1114970015202 dimer interface [polypeptide binding]; other site 1114970015203 putative PBP binding regions; other site 1114970015204 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114970015205 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1114970015206 intersubunit interface [polypeptide binding]; other site 1114970015207 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1114970015208 iron-sulfur cluster [ion binding]; other site 1114970015209 [2Fe-2S] cluster binding site [ion binding]; other site 1114970015210 Sugar fermentation stimulation protein; Region: SfsA; cl00647 1114970015211 aminotransferase; Validated; Region: PRK07337 1114970015212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970015213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970015214 homodimer interface [polypeptide binding]; other site 1114970015215 catalytic residue [active] 1114970015216 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1114970015217 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114970015218 active site 1114970015219 HIGH motif; other site 1114970015220 nucleotide binding site [chemical binding]; other site 1114970015221 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114970015222 KMSKS motif; other site 1114970015223 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114970015224 Na binding site [ion binding]; other site 1114970015225 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1114970015226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970015227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970015228 dimer interface [polypeptide binding]; other site 1114970015229 phosphorylation site [posttranslational modification] 1114970015230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970015231 ATP binding site [chemical binding]; other site 1114970015232 Mg2+ binding site [ion binding]; other site 1114970015233 G-X-G motif; other site 1114970015234 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970015235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970015236 active site 1114970015237 phosphorylation site [posttranslational modification] 1114970015238 intermolecular recognition site; other site 1114970015239 dimerization interface [polypeptide binding]; other site 1114970015240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970015241 Walker A motif; other site 1114970015242 ATP binding site [chemical binding]; other site 1114970015243 Walker B motif; other site 1114970015244 arginine finger; other site 1114970015245 poly(A) polymerase; Region: pcnB; TIGR01942 1114970015246 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1114970015247 active site 1114970015248 NTP binding site [chemical binding]; other site 1114970015249 metal binding triad [ion binding]; metal-binding site 1114970015250 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1114970015251 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1114970015252 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1114970015253 catalytic center binding site [active] 1114970015254 ATP binding site [chemical binding]; other site 1114970015255 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1114970015256 oligomerization interface [polypeptide binding]; other site 1114970015257 active site 1114970015258 metal binding site [ion binding]; metal-binding site 1114970015259 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1114970015260 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1114970015261 active site 1114970015262 ATP-binding site [chemical binding]; other site 1114970015263 pantoate-binding site; other site 1114970015264 HXXH motif; other site 1114970015265 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1114970015266 tetramerization interface [polypeptide binding]; other site 1114970015267 active site 1114970015268 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1114970015269 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1114970015270 active site 1114970015271 dimer interface [polypeptide binding]; other site 1114970015272 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1114970015273 dimer interface [polypeptide binding]; other site 1114970015274 active site 1114970015275 acetyl-CoA synthetase; Provisional; Region: PRK00174 1114970015276 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1114970015277 AMP-binding enzyme; Region: AMP-binding; cl15778 1114970015278 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970015279 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1114970015280 putative RNA binding site [nucleotide binding]; other site 1114970015281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970015282 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1114970015283 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1114970015284 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1114970015285 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1114970015286 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1114970015287 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1114970015288 Pilin (bacterial filament); Region: Pilin; pfam00114 1114970015289 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1114970015290 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1114970015291 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1114970015292 Walker A motif; other site 1114970015293 ATP binding site [chemical binding]; other site 1114970015294 Walker B motif; other site 1114970015295 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1114970015296 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1114970015297 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1114970015298 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1114970015299 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 1114970015300 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1114970015301 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1114970015302 CoA-binding site [chemical binding]; other site 1114970015303 ATP-binding [chemical binding]; other site 1114970015304 Domain of unknown function (DUF329); Region: DUF329; cl01144 1114970015305 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 1114970015306 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1114970015307 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1114970015308 Helix-turn-helix domains; Region: HTH; cl00088 1114970015309 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970015310 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970015311 dimerization interface [polypeptide binding]; other site 1114970015312 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 1114970015313 MOSC domain; Region: MOSC; pfam03473 1114970015314 Protein of unknown function (DUF3094); Region: DUF3094; pfam11293 1114970015315 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1114970015316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970015317 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970015318 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970015319 dimerization interface [polypeptide binding]; other site 1114970015320 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970015321 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970015322 dimer interface [polypeptide binding]; other site 1114970015323 putative CheW interface [polypeptide binding]; other site 1114970015324 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1114970015325 Clp amino terminal domain; Region: Clp_N; pfam02861 1114970015326 Clp amino terminal domain; Region: Clp_N; pfam02861 1114970015327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970015328 Walker A motif; other site 1114970015329 ATP binding site [chemical binding]; other site 1114970015330 Walker B motif; other site 1114970015331 arginine finger; other site 1114970015332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970015333 Walker A motif; other site 1114970015334 ATP binding site [chemical binding]; other site 1114970015335 Walker B motif; other site 1114970015336 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1114970015337 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1114970015338 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1114970015339 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1114970015340 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114970015341 RNA binding surface [nucleotide binding]; other site 1114970015342 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114970015343 active site 1114970015344 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1114970015345 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511 1114970015346 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1114970015347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970015348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970015349 dimer interface [polypeptide binding]; other site 1114970015350 phosphorylation site [posttranslational modification] 1114970015351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970015352 ATP binding site [chemical binding]; other site 1114970015353 Mg2+ binding site [ion binding]; other site 1114970015354 G-X-G motif; other site 1114970015355 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970015356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970015357 active site 1114970015358 phosphorylation site [posttranslational modification] 1114970015359 intermolecular recognition site; other site 1114970015360 dimerization interface [polypeptide binding]; other site 1114970015361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970015362 Walker A motif; other site 1114970015363 ATP binding site [chemical binding]; other site 1114970015364 Walker B motif; other site 1114970015365 arginine finger; other site 1114970015366 Helix-turn-helix domains; Region: HTH; cl00088 1114970015367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970015368 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1114970015369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970015370 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1114970015371 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1114970015372 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 1114970015373 PilX N-terminal; Region: PilX_N; pfam14341 1114970015374 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 1114970015375 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 1114970015376 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1114970015377 Type II transport protein GspH; Region: GspH; pfam12019 1114970015378 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1114970015379 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1114970015380 Type II transport protein GspH; Region: GspH; pfam12019 1114970015381 LytB protein; Region: LYTB; cl00507 1114970015382 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1114970015383 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1114970015384 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1114970015385 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1114970015386 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114970015387 active site 1114970015388 HIGH motif; other site 1114970015389 nucleotide binding site [chemical binding]; other site 1114970015390 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114970015391 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1114970015392 active site 1114970015393 KMSKS motif; other site 1114970015394 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1114970015395 tRNA binding surface [nucleotide binding]; other site 1114970015396 anticodon binding site; other site 1114970015397 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1114970015398 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1114970015399 Riboflavin kinase; Region: Flavokinase; cl03312 1114970015400 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1114970015401 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 1114970015402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1114970015403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1114970015404 CreA protein; Region: CreA; pfam05981 1114970015405 gamma-glutamyl kinase; Provisional; Region: PRK05429 1114970015406 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1114970015407 nucleotide binding site [chemical binding]; other site 1114970015408 homotetrameric interface [polypeptide binding]; other site 1114970015409 putative phosphate binding site [ion binding]; other site 1114970015410 putative allosteric binding site; other site 1114970015411 PUA domain; Region: PUA; cl00607 1114970015412 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1114970015413 GTP1/OBG; Region: GTP1_OBG; pfam01018 1114970015414 Obg GTPase; Region: Obg; cd01898 1114970015415 G1 box; other site 1114970015416 GTP/Mg2+ binding site [chemical binding]; other site 1114970015417 Switch I region; other site 1114970015418 G2 box; other site 1114970015419 G3 box; other site 1114970015420 Switch II region; other site 1114970015421 G4 box; other site 1114970015422 G5 box; other site 1114970015423 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 1114970015424 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 1114970015425 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1114970015426 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1114970015427 substrate binding pocket [chemical binding]; other site 1114970015428 chain length determination region; other site 1114970015429 substrate-Mg2+ binding site; other site 1114970015430 catalytic residues [active] 1114970015431 aspartate-rich region 1; other site 1114970015432 active site lid residues [active] 1114970015433 aspartate-rich region 2; other site 1114970015434 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1114970015435 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1114970015436 PhnA protein; Region: PhnA; pfam03831 1114970015437 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1114970015438 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1114970015439 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1114970015440 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 1114970015441 AAA domain; Region: AAA_32; pfam13654 1114970015442 ATP-dependent protease Lon; Provisional; Region: PRK13765 1114970015443 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1114970015444 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1114970015445 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1114970015446 transcription elongation factor regulatory protein; Validated; Region: PRK06342 1114970015447 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114970015448 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1114970015449 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1114970015450 active site 1114970015451 zinc binding site [ion binding]; other site 1114970015452 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1114970015453 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114970015454 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114970015455 ABC transporter; Region: ABC_tran_2; pfam12848 1114970015456 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114970015457 PAS domain; Region: PAS_9; pfam13426 1114970015458 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1114970015459 PAS domain S-box; Region: sensory_box; TIGR00229 1114970015460 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1114970015461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970015462 PAS domain; Region: PAS_9; pfam13426 1114970015463 putative active site [active] 1114970015464 heme pocket [chemical binding]; other site 1114970015465 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970015466 metal binding site [ion binding]; metal-binding site 1114970015467 active site 1114970015468 I-site; other site 1114970015469 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970015470 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1114970015471 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1114970015472 dimer interface [polypeptide binding]; other site 1114970015473 active site 1114970015474 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1114970015475 folate binding site [chemical binding]; other site 1114970015476 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114970015477 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970015478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970015479 DNA-binding site [nucleotide binding]; DNA binding site 1114970015480 FCD domain; Region: FCD; cl11656 1114970015481 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970015482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970015483 DNA-binding site [nucleotide binding]; DNA binding site 1114970015484 FCD domain; Region: FCD; cl11656 1114970015485 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1114970015486 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1114970015487 P-loop, Walker A motif; other site 1114970015488 Base recognition motif; other site 1114970015489 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1114970015490 Protein of unknown function (DUF466); Region: DUF466; cl01082 1114970015491 carbon starvation protein A; Provisional; Region: PRK15015 1114970015492 Carbon starvation protein CstA; Region: CstA; pfam02554 1114970015493 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1114970015494 DNA repair protein RadA; Provisional; Region: PRK11823 1114970015495 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1114970015496 Walker A motif/ATP binding site; other site 1114970015497 ATP binding site [chemical binding]; other site 1114970015498 Walker B motif; other site 1114970015499 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1114970015500 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1114970015501 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1114970015502 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1114970015503 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1114970015504 tetramer interface [polypeptide binding]; other site 1114970015505 heme binding pocket [chemical binding]; other site 1114970015506 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1114970015507 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1114970015508 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1114970015509 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1114970015510 FAD binding pocket [chemical binding]; other site 1114970015511 FAD binding motif [chemical binding]; other site 1114970015512 phosphate binding motif [ion binding]; other site 1114970015513 beta-alpha-beta structure motif; other site 1114970015514 NAD binding pocket [chemical binding]; other site 1114970015515 transcriptional regulator TraR; Provisional; Region: PRK13870 1114970015516 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1114970015517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970015518 DNA binding residues [nucleotide binding] 1114970015519 dimerization interface [polypeptide binding]; other site 1114970015520 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1114970015521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970015522 S-adenosylmethionine binding site [chemical binding]; other site 1114970015523 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1114970015524 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1114970015525 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1114970015526 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1114970015527 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114970015528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970015529 putative substrate translocation pore; other site 1114970015530 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1114970015531 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1114970015532 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970015533 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1114970015534 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 1114970015535 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 1114970015536 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1114970015537 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1114970015538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970015539 sequence-specific DNA binding site [nucleotide binding]; other site 1114970015540 salt bridge; other site 1114970015541 DJ-1 family protein; Region: not_thiJ; TIGR01383 1114970015542 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1114970015543 conserved cys residue [active] 1114970015544 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1114970015545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970015546 tRNA (uracil-5-)-methyltransferase; Region: trmA_only; TIGR02143 1114970015547 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1114970015548 active site 1114970015549 trimer interface [polypeptide binding]; other site 1114970015550 dimer interface [polypeptide binding]; other site 1114970015551 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1114970015552 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1114970015553 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114970015554 shikimate binding site; other site 1114970015555 NAD(P) binding site [chemical binding]; other site 1114970015556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970015557 Helix-turn-helix domains; Region: HTH; cl00088 1114970015558 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114970015559 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1114970015560 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1114970015561 dimer interface [polypeptide binding]; other site 1114970015562 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1114970015563 active site 1114970015564 Fe binding site [ion binding]; other site 1114970015565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970015566 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970015567 putative substrate translocation pore; other site 1114970015568 EamA-like transporter family; Region: EamA; cl01037 1114970015569 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114970015570 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970015571 Helix-turn-helix domains; Region: HTH; cl00088 1114970015572 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970015573 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 1114970015574 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970015575 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1114970015576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970015577 active site 1114970015578 motif I; other site 1114970015579 motif II; other site 1114970015580 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1114970015581 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1114970015582 active site 1114970015583 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1114970015584 catalytic triad [active] 1114970015585 dimer interface [polypeptide binding]; other site 1114970015586 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114970015587 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970015588 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970015589 DNA-binding site [nucleotide binding]; DNA binding site 1114970015590 FCD domain; Region: FCD; cl11656 1114970015591 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1114970015592 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1114970015593 putative active site [active] 1114970015594 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 1114970015595 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1114970015596 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1114970015597 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1114970015598 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1114970015599 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970015600 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970015601 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1114970015602 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970015603 carboxyltransferase (CT) interaction site; other site 1114970015604 biotinylation site [posttranslational modification]; other site 1114970015605 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970015606 Cache domain; Region: Cache_1; pfam02743 1114970015607 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1114970015608 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970015609 dimerization interface [polypeptide binding]; other site 1114970015610 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970015611 dimer interface [polypeptide binding]; other site 1114970015612 putative CheW interface [polypeptide binding]; other site 1114970015613 HI0933-like protein; Region: HI0933_like; pfam03486 1114970015614 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970015615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970015616 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114970015617 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1114970015618 ATP binding site [chemical binding]; other site 1114970015619 Mg++ binding site [ion binding]; other site 1114970015620 motif III; other site 1114970015621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970015622 nucleotide binding region [chemical binding]; other site 1114970015623 ATP-binding site [chemical binding]; other site 1114970015624 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1114970015625 EamA-like transporter family; Region: EamA; cl01037 1114970015626 EamA-like transporter family; Region: EamA; cl01037 1114970015627 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1114970015628 Helix-turn-helix domains; Region: HTH; cl00088 1114970015629 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970015630 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1114970015631 active site 1114970015632 catalytic site [active] 1114970015633 substrate binding site [chemical binding]; other site 1114970015634 LabA_like proteins; Region: LabA; cd10911 1114970015635 putative metal binding site [ion binding]; other site 1114970015636 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 1114970015637 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 1114970015638 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1114970015639 putative catalytic site [active] 1114970015640 putative metal binding site [ion binding]; other site 1114970015641 putative phosphate binding site [ion binding]; other site 1114970015642 Helix-turn-helix domains; Region: HTH; cl00088 1114970015643 Integrase core domain; Region: rve_3; cl15866 1114970015644 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1114970015645 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970015646 ATP binding site [chemical binding]; other site 1114970015647 putative Mg++ binding site [ion binding]; other site 1114970015648 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970015649 nucleotide binding region [chemical binding]; other site 1114970015650 ATP-binding site [chemical binding]; other site 1114970015651 Helicase associated domain (HA2); Region: HA2; cl04503 1114970015652 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1114970015653 Cation efflux family; Region: Cation_efflux; cl00316 1114970015654 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 1114970015655 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1114970015656 Helix-turn-helix domains; Region: HTH; cl00088 1114970015657 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970015658 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 1114970015659 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1114970015660 pseudouridine synthase; Region: TIGR00093 1114970015661 active site 1114970015662 AMP nucleosidase; Provisional; Region: PRK08292 1114970015663 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1114970015664 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1114970015665 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1114970015666 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970015667 active site 1114970015668 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1114970015669 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1114970015670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970015671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970015672 dimer interface [polypeptide binding]; other site 1114970015673 phosphorylation site [posttranslational modification] 1114970015674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970015675 ATP binding site [chemical binding]; other site 1114970015676 Mg2+ binding site [ion binding]; other site 1114970015677 G-X-G motif; other site 1114970015678 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970015679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970015680 active site 1114970015681 phosphorylation site [posttranslational modification] 1114970015682 intermolecular recognition site; other site 1114970015683 dimerization interface [polypeptide binding]; other site 1114970015684 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1114970015685 dimer interface [polypeptide binding]; other site 1114970015686 substrate binding site [chemical binding]; other site 1114970015687 ATP binding site [chemical binding]; other site 1114970015688 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1114970015689 thiamine phosphate binding site [chemical binding]; other site 1114970015690 active site 1114970015691 pyrophosphate binding site [ion binding]; other site 1114970015692 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1114970015693 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970015694 inhibitor-cofactor binding pocket; inhibition site 1114970015695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970015696 catalytic residue [active] 1114970015697 Sel1 repeat; Region: Sel1; cl02723 1114970015698 Sel1 repeat; Region: Sel1; cl02723 1114970015699 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 1114970015700 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1114970015701 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1114970015702 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970015703 FeS/SAM binding site; other site 1114970015704 TRAM domain; Region: TRAM; cl01282 1114970015705 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1114970015706 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970015707 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 1114970015708 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1114970015709 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114970015710 Transporter associated domain; Region: CorC_HlyC; cl08393 1114970015711 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1114970015712 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1114970015713 putative active site [active] 1114970015714 catalytic triad [active] 1114970015715 putative dimer interface [polypeptide binding]; other site 1114970015716 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1114970015717 putative active site [active] 1114970015718 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1114970015719 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1114970015720 HIGH motif; other site 1114970015721 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114970015722 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114970015723 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114970015724 active site 1114970015725 KMSKS motif; other site 1114970015726 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1114970015727 tRNA binding surface [nucleotide binding]; other site 1114970015728 Lipopolysaccharide-assembly; Region: LptE; cl01125 1114970015729 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1114970015730 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1114970015731 Domain of unknown function; Region: DUF331; cl01149 1114970015732 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1114970015733 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1114970015734 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1114970015735 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1114970015736 dimer interface [polypeptide binding]; other site 1114970015737 catalytic triad [active] 1114970015738 lipoyl synthase; Provisional; Region: PRK05481 1114970015739 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970015740 FeS/SAM binding site; other site 1114970015741 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1114970015742 Protein of unknown function (DUF493); Region: DUF493; cl01102 1114970015743 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1114970015744 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970015745 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1114970015746 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1114970015747 Sporulation related domain; Region: SPOR; cl10051 1114970015748 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1114970015749 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1114970015750 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970015751 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1114970015752 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1114970015753 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114970015754 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970015755 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 1114970015756 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 1114970015757 Oligomerisation domain; Region: Oligomerisation; cl00519 1114970015758 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1114970015759 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1114970015760 active site 1114970015761 (T/H)XGH motif; other site 1114970015762 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1114970015763 putative catalytic cysteine [active] 1114970015764 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1114970015765 active site 1114970015766 DNA binding site [nucleotide binding] 1114970015767 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114970015768 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114970015769 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1114970015770 active site 1114970015771 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1114970015772 LrgB-like family; Region: LrgB; cl00596 1114970015773 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1114970015774 putative active site [active] 1114970015775 putative catalytic site [active] 1114970015776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1114970015777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1114970015778 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 1114970015779 Peptidase C13 family; Region: Peptidase_C13; cl02159 1114970015780 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1114970015781 NAD binding site [chemical binding]; other site 1114970015782 active site 1114970015783 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 1114970015784 aromatic acid decarboxylase; Validated; Region: PRK05920 1114970015785 Flavoprotein; Region: Flavoprotein; cl08021 1114970015786 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1114970015787 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114970015788 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114970015789 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114970015790 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1114970015791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970015792 Walker A motif; other site 1114970015793 ATP binding site [chemical binding]; other site 1114970015794 Walker B motif; other site 1114970015795 arginine finger; other site 1114970015796 Helix-turn-helix domains; Region: HTH; cl00088 1114970015797 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114970015798 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970015799 NAD(P) binding site [chemical binding]; other site 1114970015800 catalytic residues [active] 1114970015801 ethanolamine permease; Region: 2A0305; TIGR00908 1114970015802 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1114970015803 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1114970015804 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 1114970015805 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114970015806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970015807 Coenzyme A binding pocket [chemical binding]; other site 1114970015808 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114970015809 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 1114970015810 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1114970015811 dimer interface [polypeptide binding]; other site 1114970015812 substrate binding site [chemical binding]; other site 1114970015813 metal binding sites [ion binding]; metal-binding site 1114970015814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970015815 non-specific DNA binding site [nucleotide binding]; other site 1114970015816 salt bridge; other site 1114970015817 sequence-specific DNA binding site [nucleotide binding]; other site 1114970015818 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970015819 Catalytic site [active] 1114970015820 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1114970015821 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1114970015822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970015823 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1114970015824 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1114970015825 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1114970015826 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1114970015827 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1114970015828 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970015829 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970015830 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970015831 Integrase core domain; Region: rve; cl01316 1114970015832 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970015833 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970015834 Helix-turn-helix domains; Region: HTH; cl00088 1114970015835 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1114970015836 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970015837 ATP binding site [chemical binding]; other site 1114970015838 putative Mg++ binding site [ion binding]; other site 1114970015839 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970015840 nucleotide binding region [chemical binding]; other site 1114970015841 ATP-binding site [chemical binding]; other site 1114970015842 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1114970015843 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114970015844 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1114970015845 ligand binding site [chemical binding]; other site 1114970015846 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1114970015847 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1114970015848 active site 1114970015849 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1114970015850 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970015851 NAD(P) binding site [chemical binding]; other site 1114970015852 catalytic residues [active] 1114970015853 homoserine dehydrogenase; Provisional; Region: PRK06270 1114970015854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970015855 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1114970015856 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970015857 Helix-turn-helix domains; Region: HTH; cl00088 1114970015858 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970015859 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1114970015860 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 1114970015861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970015862 catalytic residue [active] 1114970015863 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970015864 Helix-turn-helix domains; Region: HTH; cl00088 1114970015865 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970015866 dimerization interface [polypeptide binding]; other site 1114970015867 substrate binding pocket [chemical binding]; other site 1114970015868 S-methylmethionine transporter; Provisional; Region: PRK11387 1114970015869 cystathionine gamma-synthase; Provisional; Region: PRK08249 1114970015870 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1114970015871 homodimer interface [polypeptide binding]; other site 1114970015872 substrate-cofactor binding pocket; other site 1114970015873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970015874 catalytic residue [active] 1114970015875 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970015876 RHS Repeat; Region: RHS_repeat; cl11982 1114970015877 RHS Repeat; Region: RHS_repeat; cl11982 1114970015878 RHS Repeat; Region: RHS_repeat; cl11982 1114970015879 RHS Repeat; Region: RHS_repeat; cl11982 1114970015880 RHS Repeat; Region: RHS_repeat; cl11982 1114970015881 RHS Repeat; Region: RHS_repeat; cl11982 1114970015882 RHS Repeat; Region: RHS_repeat; cl11982 1114970015883 RHS Repeat; Region: RHS_repeat; cl11982 1114970015884 RHS Repeat; Region: RHS_repeat; cl11982 1114970015885 RHS Repeat; Region: RHS_repeat; cl11982 1114970015886 RHS protein; Region: RHS; pfam03527 1114970015887 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970015888 Pertussis toxin, subunit 1; Region: Pertussis_S1; cl03779 1114970015889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970015890 Coenzyme A binding pocket [chemical binding]; other site 1114970015891 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1114970015892 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114970015893 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970015894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970015895 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1114970015896 active site 1114970015897 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1114970015898 active site 1114970015899 catalytic residues [active] 1114970015900 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114970015901 putative acyl-acceptor binding pocket; other site 1114970015902 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 1114970015903 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503 1114970015904 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 1114970015905 Predicted membrane protein [Function unknown]; Region: COG3766 1114970015906 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1114970015907 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1114970015908 Ion channel; Region: Ion_trans_2; cl11596 1114970015909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970015910 PspA/IM30 family; Region: PspA_IM30; pfam04012 1114970015911 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 1114970015912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1114970015913 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1114970015914 Predicted secreted protein [Function unknown]; Region: COG5445 1114970015915 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1114970015916 Predicted secreted protein [Function unknown]; Region: COG5445 1114970015917 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1114970015918 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1114970015919 MG2 domain; Region: A2M_N; pfam01835 1114970015920 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 1114970015921 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1114970015922 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1114970015923 surface patch; other site 1114970015924 thioester region; other site 1114970015925 Protein of unknown function (DUF1175); Region: DUF1175; cl14898 1114970015926 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; cl01916 1114970015927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1114970015928 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1114970015929 Fic family protein [Function unknown]; Region: COG3177 1114970015930 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 1114970015931 Fic/DOC family; Region: Fic; cl00960 1114970015932 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 1114970015933 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1114970015934 substrate binding pocket [chemical binding]; other site 1114970015935 chain length determination region; other site 1114970015936 substrate-Mg2+ binding site; other site 1114970015937 catalytic residues [active] 1114970015938 aspartate-rich region 1; other site 1114970015939 active site lid residues [active] 1114970015940 aspartate-rich region 2; other site 1114970015941 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1114970015942 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1114970015943 TPP-binding site; other site 1114970015944 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1114970015945 PYR/PP interface [polypeptide binding]; other site 1114970015946 dimer interface [polypeptide binding]; other site 1114970015947 TPP binding site [chemical binding]; other site 1114970015948 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114970015949 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1114970015950 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970015951 N-terminal plug; other site 1114970015952 ligand-binding site [chemical binding]; other site 1114970015953 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1114970015954 cobalamin binding residues [chemical binding]; other site 1114970015955 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1114970015956 putative BtuC binding residues; other site 1114970015957 dimer interface [polypeptide binding]; other site 1114970015958 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1114970015959 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1114970015960 dimerization interface [polypeptide binding]; other site 1114970015961 active site 1114970015962 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 1114970015963 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970015964 substrate binding pocket [chemical binding]; other site 1114970015965 membrane-bound complex binding site; other site 1114970015966 hinge residues; other site 1114970015967 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1114970015968 tetramer interfaces [polypeptide binding]; other site 1114970015969 binuclear metal-binding site [ion binding]; other site 1114970015970 thiamine monophosphate kinase; Provisional; Region: PRK05731 1114970015971 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1114970015972 ATP binding site [chemical binding]; other site 1114970015973 dimerization interface [polypeptide binding]; other site 1114970015974 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1114970015975 putative RNA binding site [nucleotide binding]; other site 1114970015976 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1114970015977 homopentamer interface [polypeptide binding]; other site 1114970015978 active site 1114970015979 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1114970015980 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 1114970015981 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1114970015982 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1114970015983 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1114970015984 Lumazine binding domain; Region: Lum_binding; pfam00677 1114970015985 Lumazine binding domain; Region: Lum_binding; pfam00677 1114970015986 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1114970015987 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1114970015988 catalytic motif [active] 1114970015989 Zn binding site [ion binding]; other site 1114970015990 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1114970015991 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1114970015992 ATP cone domain; Region: ATP-cone; pfam03477 1114970015993 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 1114970015994 Predicted methyltransferase [General function prediction only]; Region: COG3897 1114970015995 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1114970015996 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1114970015997 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 1114970015998 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114970015999 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1114970016000 Walker A/P-loop; other site 1114970016001 ATP binding site [chemical binding]; other site 1114970016002 Q-loop/lid; other site 1114970016003 ABC transporter signature motif; other site 1114970016004 Walker B; other site 1114970016005 D-loop; other site 1114970016006 H-loop/switch region; other site 1114970016007 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114970016008 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1114970016009 FtsX-like permease family; Region: FtsX; cl15850 1114970016010 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 1114970016011 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1114970016012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016013 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1114970016014 NAD(P) binding site [chemical binding]; other site 1114970016015 active site 1114970016016 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1114970016017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016018 NAD(P) binding site [chemical binding]; other site 1114970016019 active site 1114970016020 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1114970016021 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970016022 ATP binding site [chemical binding]; other site 1114970016023 putative Mg++ binding site [ion binding]; other site 1114970016024 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970016025 nucleotide binding region [chemical binding]; other site 1114970016026 ATP-binding site [chemical binding]; other site 1114970016027 DEAD/H associated; Region: DEAD_assoc; pfam08494 1114970016028 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1114970016029 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114970016030 Protein of unknown function DUF72; Region: DUF72; cl00777 1114970016031 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1114970016032 putative catalytic site [active] 1114970016033 putative metal binding site [ion binding]; other site 1114970016034 putative phosphate binding site [ion binding]; other site 1114970016035 cardiolipin synthase 2; Provisional; Region: PRK11263 1114970016036 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1114970016037 putative active site [active] 1114970016038 catalytic site [active] 1114970016039 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1114970016040 putative active site [active] 1114970016041 catalytic site [active] 1114970016042 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1114970016043 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1114970016044 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1114970016045 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 1114970016046 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970016047 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1114970016048 conserved cys residue [active] 1114970016049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970016050 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1114970016051 catalytic triad [active] 1114970016052 conserved cis-peptide bond; other site 1114970016053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970016054 Predicted ATPase [General function prediction only]; Region: COG3899 1114970016055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970016056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970016057 binding surface 1114970016058 TPR motif; other site 1114970016059 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114970016060 TPR repeat; Region: TPR_11; pfam13414 1114970016061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970016062 binding surface 1114970016063 TPR motif; other site 1114970016064 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1114970016065 dimer interface [polypeptide binding]; other site 1114970016066 ssDNA binding site [nucleotide binding]; other site 1114970016067 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114970016068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970016069 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970016070 putative substrate translocation pore; other site 1114970016071 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1114970016072 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1114970016073 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1114970016074 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 1114970016075 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1114970016076 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1114970016077 heme binding site [chemical binding]; other site 1114970016078 ferroxidase pore; other site 1114970016079 ferroxidase diiron center [ion binding]; other site 1114970016080 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1114970016081 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1114970016082 tetramer interface [polypeptide binding]; other site 1114970016083 heme binding pocket [chemical binding]; other site 1114970016084 NADPH binding site [chemical binding]; other site 1114970016085 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 1114970016086 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1114970016087 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1114970016088 alphaNTD homodimer interface [polypeptide binding]; other site 1114970016089 alphaNTD - beta interaction site [polypeptide binding]; other site 1114970016090 alphaNTD - beta' interaction site [polypeptide binding]; other site 1114970016091 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1114970016092 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1114970016093 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1114970016094 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114970016095 RNA binding surface [nucleotide binding]; other site 1114970016096 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 1114970016097 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1114970016098 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1114970016099 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1114970016100 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1114970016101 SecY translocase; Region: SecY; pfam00344 1114970016102 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 1114970016103 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1114970016104 23S rRNA binding site [nucleotide binding]; other site 1114970016105 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1114970016106 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1114970016107 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1114970016108 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1114970016109 5S rRNA interface [nucleotide binding]; other site 1114970016110 23S rRNA interface [nucleotide binding]; other site 1114970016111 L5 interface [polypeptide binding]; other site 1114970016112 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1114970016113 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 1114970016114 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1114970016115 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1114970016116 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1114970016117 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1114970016118 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1114970016119 KOW motif; Region: KOW; cl00354 1114970016120 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 1114970016121 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 1114970016122 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1114970016123 23S rRNA interface [nucleotide binding]; other site 1114970016124 putative translocon interaction site; other site 1114970016125 signal recognition particle (SRP54) interaction site; other site 1114970016126 L23 interface [polypeptide binding]; other site 1114970016127 trigger factor interaction site; other site 1114970016128 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1114970016129 23S rRNA interface [nucleotide binding]; other site 1114970016130 5S rRNA interface [nucleotide binding]; other site 1114970016131 putative antibiotic binding site [chemical binding]; other site 1114970016132 L25 interface [polypeptide binding]; other site 1114970016133 L27 interface [polypeptide binding]; other site 1114970016134 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1114970016135 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1114970016136 G-X-X-G motif; other site 1114970016137 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1114970016138 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1114970016139 putative translocon binding site; other site 1114970016140 protein-rRNA interface [nucleotide binding]; other site 1114970016141 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 1114970016142 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1114970016143 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1114970016144 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1114970016145 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 1114970016146 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1114970016147 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 1114970016148 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 1114970016149 elongation factor Tu; Reviewed; Region: PRK00049 1114970016150 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1114970016151 G1 box; other site 1114970016152 GEF interaction site [polypeptide binding]; other site 1114970016153 GTP/Mg2+ binding site [chemical binding]; other site 1114970016154 Switch I region; other site 1114970016155 G2 box; other site 1114970016156 G3 box; other site 1114970016157 Switch II region; other site 1114970016158 G4 box; other site 1114970016159 G5 box; other site 1114970016160 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1114970016161 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1114970016162 Antibiotic Binding Site [chemical binding]; other site 1114970016163 elongation factor G; Reviewed; Region: PRK00007 1114970016164 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1114970016165 G1 box; other site 1114970016166 putative GEF interaction site [polypeptide binding]; other site 1114970016167 GTP/Mg2+ binding site [chemical binding]; other site 1114970016168 Switch I region; other site 1114970016169 G2 box; other site 1114970016170 G3 box; other site 1114970016171 Switch II region; other site 1114970016172 G4 box; other site 1114970016173 G5 box; other site 1114970016174 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1114970016175 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1114970016176 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1114970016177 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 1114970016178 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1114970016179 S17 interaction site [polypeptide binding]; other site 1114970016180 S8 interaction site; other site 1114970016181 16S rRNA interaction site [nucleotide binding]; other site 1114970016182 streptomycin interaction site [chemical binding]; other site 1114970016183 23S rRNA interaction site [nucleotide binding]; other site 1114970016184 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1114970016185 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1114970016186 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1114970016187 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 1114970016188 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1114970016189 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 1114970016190 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1114970016191 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1114970016192 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1114970016193 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 1114970016194 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1114970016195 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1114970016196 DNA binding site [nucleotide binding] 1114970016197 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1114970016198 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 1114970016199 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 1114970016200 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1114970016201 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1114970016202 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1114970016203 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 1114970016204 RPB11 interaction site [polypeptide binding]; other site 1114970016205 RPB12 interaction site [polypeptide binding]; other site 1114970016206 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1114970016207 RPB3 interaction site [polypeptide binding]; other site 1114970016208 RPB1 interaction site [polypeptide binding]; other site 1114970016209 RPB11 interaction site [polypeptide binding]; other site 1114970016210 RPB10 interaction site [polypeptide binding]; other site 1114970016211 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1114970016212 peripheral dimer interface [polypeptide binding]; other site 1114970016213 core dimer interface [polypeptide binding]; other site 1114970016214 L10 interface [polypeptide binding]; other site 1114970016215 L11 interface [polypeptide binding]; other site 1114970016216 putative EF-Tu interaction site [polypeptide binding]; other site 1114970016217 putative EF-G interaction site [polypeptide binding]; other site 1114970016218 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1114970016219 23S rRNA interface [nucleotide binding]; other site 1114970016220 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1114970016221 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1114970016222 mRNA/rRNA interface [nucleotide binding]; other site 1114970016223 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1114970016224 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1114970016225 23S rRNA interface [nucleotide binding]; other site 1114970016226 L7/L12 interface [polypeptide binding]; other site 1114970016227 putative thiostrepton binding site; other site 1114970016228 L25 interface [polypeptide binding]; other site 1114970016229 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 1114970016230 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1114970016231 putative homodimer interface [polypeptide binding]; other site 1114970016232 KOW motif; Region: KOW; cl00354 1114970016233 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 1114970016234 elongation factor Tu; Reviewed; Region: PRK00049 1114970016235 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1114970016236 G1 box; other site 1114970016237 GEF interaction site [polypeptide binding]; other site 1114970016238 GTP/Mg2+ binding site [chemical binding]; other site 1114970016239 Switch I region; other site 1114970016240 G2 box; other site 1114970016241 G3 box; other site 1114970016242 Switch II region; other site 1114970016243 G4 box; other site 1114970016244 G5 box; other site 1114970016245 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1114970016246 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1114970016247 Antibiotic Binding Site [chemical binding]; other site 1114970016248 Type III pantothenate kinase; Region: Pan_kinase; cl09130 1114970016249 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 1114970016250 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1114970016251 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1114970016252 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1114970016253 active site 1114970016254 HIGH motif; other site 1114970016255 dimer interface [polypeptide binding]; other site 1114970016256 KMSKS motif; other site 1114970016257 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1114970016258 putative peptidase; Provisional; Region: PRK11649 1114970016259 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 1114970016260 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1114970016261 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1114970016262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016263 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1114970016264 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1114970016265 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1114970016266 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1114970016267 FMN binding site [chemical binding]; other site 1114970016268 substrate binding site [chemical binding]; other site 1114970016269 putative catalytic residue [active] 1114970016270 Protein of unknown function (DUF805); Region: DUF805; cl01224 1114970016271 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1114970016272 classical (c) SDRs; Region: SDR_c; cd05233 1114970016273 NAD(P) binding site [chemical binding]; other site 1114970016274 active site 1114970016275 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1114970016276 nucleotide binding site/active site [active] 1114970016277 HIT family signature motif; other site 1114970016278 catalytic residue [active] 1114970016279 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1114970016280 diiron binding motif [ion binding]; other site 1114970016281 OsmC-like protein; Region: OsmC; cl00767 1114970016282 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1114970016283 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970016284 ligand binding site [chemical binding]; other site 1114970016285 flexible hinge region; other site 1114970016286 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1114970016287 putative switch regulator; other site 1114970016288 non-specific DNA interactions [nucleotide binding]; other site 1114970016289 DNA binding site [nucleotide binding] 1114970016290 sequence specific DNA binding site [nucleotide binding]; other site 1114970016291 putative cAMP binding site [chemical binding]; other site 1114970016292 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1114970016293 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1114970016294 active site 1114970016295 ribulose/triose binding site [chemical binding]; other site 1114970016296 phosphate binding site [ion binding]; other site 1114970016297 substrate (anthranilate) binding pocket [chemical binding]; other site 1114970016298 product (indole) binding pocket [chemical binding]; other site 1114970016299 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1114970016300 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1114970016301 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1114970016302 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1114970016303 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1114970016304 glutamine binding [chemical binding]; other site 1114970016305 catalytic triad [active] 1114970016306 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1114970016307 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 1114970016308 active site 1114970016309 catalytic triad [active] 1114970016310 oxyanion hole [active] 1114970016311 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1114970016312 anthranilate synthase component I; Provisional; Region: PRK13565 1114970016313 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114970016314 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1114970016315 phosphoglycolate phosphatase; Provisional; Region: PRK13223 1114970016316 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114970016317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970016318 motif II; other site 1114970016319 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1114970016320 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1114970016321 substrate binding site [chemical binding]; other site 1114970016322 hexamer interface [polypeptide binding]; other site 1114970016323 metal binding site [ion binding]; metal-binding site 1114970016324 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1114970016325 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1114970016326 active site 1114970016327 NAD binding site [chemical binding]; other site 1114970016328 metal binding site [ion binding]; metal-binding site 1114970016329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970016330 dimer interface [polypeptide binding]; other site 1114970016331 conserved gate region; other site 1114970016332 putative PBP binding loops; other site 1114970016333 ABC-ATPase subunit interface; other site 1114970016334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970016335 dimer interface [polypeptide binding]; other site 1114970016336 conserved gate region; other site 1114970016337 putative PBP binding loops; other site 1114970016338 ABC-ATPase subunit interface; other site 1114970016339 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1114970016340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970016341 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970016342 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 1114970016343 Walker A/P-loop; other site 1114970016344 ATP binding site [chemical binding]; other site 1114970016345 Q-loop/lid; other site 1114970016346 ABC transporter signature motif; other site 1114970016347 Walker B; other site 1114970016348 D-loop; other site 1114970016349 H-loop/switch region; other site 1114970016350 TOBE domain; Region: TOBE_2; cl01440 1114970016351 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970016352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970016353 active site 1114970016354 phosphorylation site [posttranslational modification] 1114970016355 intermolecular recognition site; other site 1114970016356 dimerization interface [polypeptide binding]; other site 1114970016357 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970016358 DNA binding residues [nucleotide binding] 1114970016359 dimerization interface [polypeptide binding]; other site 1114970016360 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970016361 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970016362 substrate binding pocket [chemical binding]; other site 1114970016363 membrane-bound complex binding site; other site 1114970016364 hinge residues; other site 1114970016365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970016366 PAS domain; Region: PAS_9; pfam13426 1114970016367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970016368 putative active site [active] 1114970016369 heme pocket [chemical binding]; other site 1114970016370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114970016371 Histidine kinase; Region: HisKA_3; pfam07730 1114970016372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970016373 ATP binding site [chemical binding]; other site 1114970016374 Mg2+ binding site [ion binding]; other site 1114970016375 G-X-G motif; other site 1114970016376 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 1114970016377 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1114970016378 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1114970016379 putative metal binding site [ion binding]; other site 1114970016380 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114970016381 HSP70 interaction site [polypeptide binding]; other site 1114970016382 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1114970016383 Substrate binding site; other site 1114970016384 metal-binding site 1114970016385 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970016386 Phosphotransferase enzyme family; Region: APH; pfam01636 1114970016387 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1114970016388 OstA-like protein; Region: OstA; cl00844 1114970016389 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1114970016390 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1114970016391 SurA N-terminal domain; Region: SurA_N_3; cl07813 1114970016392 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1114970016393 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1114970016394 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1114970016395 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1114970016396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970016397 Protein of unknown function (DUF525); Region: DUF525; cl01119 1114970016398 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1114970016399 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1114970016400 active site 1114970016401 metal binding site [ion binding]; metal-binding site 1114970016402 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1114970016403 active site residue [active] 1114970016404 PrkA family serine protein kinase; Provisional; Region: PRK15455 1114970016405 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1114970016406 Uncharacterized conserved protein [Function unknown]; Region: COG2718 1114970016407 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114970016408 SpoVR family protein; Provisional; Region: PRK11767 1114970016409 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1114970016410 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1114970016411 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1114970016412 active site 1114970016413 NTP binding site [chemical binding]; other site 1114970016414 metal binding triad [ion binding]; metal-binding site 1114970016415 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1114970016416 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114970016417 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1114970016418 catalytic center binding site [active] 1114970016419 ATP binding site [chemical binding]; other site 1114970016420 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1114970016421 homooctamer interface [polypeptide binding]; other site 1114970016422 active site 1114970016423 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1114970016424 UGMP family protein; Validated; Region: PRK09604 1114970016425 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1114970016426 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 1114970016427 DNA primase, catalytic core; Region: dnaG; TIGR01391 1114970016428 CHC2 zinc finger; Region: zf-CHC2; cl15369 1114970016429 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1114970016430 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1114970016431 active site 1114970016432 metal binding site [ion binding]; metal-binding site 1114970016433 interdomain interaction site; other site 1114970016434 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1114970016435 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 1114970016436 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1114970016437 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1114970016438 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1114970016439 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1114970016440 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970016441 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114970016442 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970016443 DNA binding residues [nucleotide binding] 1114970016444 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970016445 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970016446 substrate binding pocket [chemical binding]; other site 1114970016447 membrane-bound complex binding site; other site 1114970016448 hinge residues; other site 1114970016449 PAS domain S-box; Region: sensory_box; TIGR00229 1114970016450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970016451 putative active site [active] 1114970016452 heme pocket [chemical binding]; other site 1114970016453 PAS domain S-box; Region: sensory_box; TIGR00229 1114970016454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970016455 putative active site [active] 1114970016456 heme pocket [chemical binding]; other site 1114970016457 PAS domain S-box; Region: sensory_box; TIGR00229 1114970016458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970016459 putative active site [active] 1114970016460 heme pocket [chemical binding]; other site 1114970016461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970016462 PAS domain; Region: PAS_9; pfam13426 1114970016463 putative active site [active] 1114970016464 heme pocket [chemical binding]; other site 1114970016465 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970016466 metal binding site [ion binding]; metal-binding site 1114970016467 active site 1114970016468 I-site; other site 1114970016469 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970016470 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1114970016471 Helix-turn-helix domains; Region: HTH; cl00088 1114970016472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970016473 dimerization interface [polypeptide binding]; other site 1114970016474 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1114970016475 heterodimer interface [polypeptide binding]; other site 1114970016476 multimer interface [polypeptide binding]; other site 1114970016477 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1114970016478 active site 1114970016479 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1114970016480 heterodimer interface [polypeptide binding]; other site 1114970016481 active site 1114970016482 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970016483 Helix-turn-helix domains; Region: HTH; cl00088 1114970016484 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970016485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970016486 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1114970016487 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1114970016488 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114970016489 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1114970016490 putative active site [active] 1114970016491 catalytic triad [active] 1114970016492 putative dimer interface [polypeptide binding]; other site 1114970016493 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 1114970016494 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1114970016495 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114970016496 PqqA family; Region: PqqA; cl15372 1114970016497 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970016498 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1114970016499 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1114970016500 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1114970016501 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970016502 FeS/SAM binding site; other site 1114970016503 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1114970016504 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1114970016505 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1114970016506 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970016507 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 1114970016508 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1114970016509 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1114970016510 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970016511 active site 1114970016512 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1114970016513 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1114970016514 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1114970016515 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1114970016516 FAD binding site [chemical binding]; other site 1114970016517 substrate binding site [chemical binding]; other site 1114970016518 catalytic residues [active] 1114970016519 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1114970016520 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970016521 metal binding site [ion binding]; metal-binding site 1114970016522 active site 1114970016523 I-site; other site 1114970016524 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1114970016525 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1114970016526 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970016527 active site 1114970016528 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1114970016529 AAA domain; Region: AAA_26; pfam13500 1114970016530 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970016531 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1114970016532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970016533 S-adenosylmethionine binding site [chemical binding]; other site 1114970016534 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 1114970016535 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1114970016536 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1114970016537 substrate-cofactor binding pocket; other site 1114970016538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970016539 catalytic residue [active] 1114970016540 biotin synthase; Provisional; Region: PRK15108 1114970016541 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970016542 FeS/SAM binding site; other site 1114970016543 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 1114970016544 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1114970016545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970016546 active site 1114970016547 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1114970016548 Helix-turn-helix domains; Region: HTH; cl00088 1114970016549 TOBE domain; Region: TOBE_2; cl01440 1114970016550 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1114970016551 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970016552 Phosphotransferase enzyme family; Region: APH; pfam01636 1114970016553 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1114970016554 EamA-like transporter family; Region: EamA; cl01037 1114970016555 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1114970016556 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1114970016557 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1114970016558 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1114970016559 active site 1114970016560 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970016561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970016562 active site 1114970016563 phosphorylation site [posttranslational modification] 1114970016564 intermolecular recognition site; other site 1114970016565 dimerization interface [polypeptide binding]; other site 1114970016566 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1114970016567 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1114970016568 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1114970016569 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1114970016570 metal binding triad; other site 1114970016571 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1114970016572 active site 1114970016573 catalytic site [active] 1114970016574 substrate binding site [chemical binding]; other site 1114970016575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970016576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114970016577 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970016578 FecR protein; Region: FecR; pfam04773 1114970016579 Secretin and TonB N terminus short domain; Region: STN; cl06624 1114970016580 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1114970016581 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970016582 N-terminal plug; other site 1114970016583 ligand-binding site [chemical binding]; other site 1114970016584 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1114970016585 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1114970016586 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1114970016587 putative glutathione S-transferase; Provisional; Region: PRK10357 1114970016588 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1114970016589 putative C-terminal domain interface [polypeptide binding]; other site 1114970016590 putative GSH binding site (G-site) [chemical binding]; other site 1114970016591 putative dimer interface [polypeptide binding]; other site 1114970016592 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1114970016593 dimer interface [polypeptide binding]; other site 1114970016594 N-terminal domain interface [polypeptide binding]; other site 1114970016595 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970016596 Inner membrane protein CreD; Region: CreD; cl01844 1114970016597 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970016598 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114970016599 sensory histidine kinase CreC; Provisional; Region: PRK11100 1114970016600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970016601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970016602 dimer interface [polypeptide binding]; other site 1114970016603 phosphorylation site [posttranslational modification] 1114970016604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970016605 ATP binding site [chemical binding]; other site 1114970016606 Mg2+ binding site [ion binding]; other site 1114970016607 G-X-G motif; other site 1114970016608 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1114970016609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970016610 active site 1114970016611 phosphorylation site [posttranslational modification] 1114970016612 intermolecular recognition site; other site 1114970016613 dimerization interface [polypeptide binding]; other site 1114970016614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970016615 DNA binding site [nucleotide binding] 1114970016616 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970016617 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 1114970016618 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114970016619 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1114970016620 putative acyl-acceptor binding pocket; other site 1114970016621 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970016622 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1114970016623 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1114970016624 DNA-binding site [nucleotide binding]; DNA binding site 1114970016625 RNA-binding motif; other site 1114970016626 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970016627 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1114970016628 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1114970016629 NAD binding site [chemical binding]; other site 1114970016630 catalytic Zn binding site [ion binding]; other site 1114970016631 structural Zn binding site [ion binding]; other site 1114970016632 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1114970016633 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1114970016634 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1114970016635 putative active site [active] 1114970016636 putative substrate binding site [chemical binding]; other site 1114970016637 putative cosubstrate binding site; other site 1114970016638 catalytic site [active] 1114970016639 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1114970016640 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1114970016641 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1114970016642 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114970016643 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 1114970016644 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1114970016645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016646 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1114970016647 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1114970016648 dimer interface [polypeptide binding]; other site 1114970016649 active site 1114970016650 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1114970016651 folate binding site [chemical binding]; other site 1114970016652 TraX protein; Region: TraX; cl05434 1114970016653 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1114970016654 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1114970016655 tetramer interface [polypeptide binding]; other site 1114970016656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970016657 catalytic residue [active] 1114970016658 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1114970016659 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1114970016660 FAD binding pocket [chemical binding]; other site 1114970016661 FAD binding motif [chemical binding]; other site 1114970016662 phosphate binding motif [ion binding]; other site 1114970016663 beta-alpha-beta structure motif; other site 1114970016664 NAD binding pocket [chemical binding]; other site 1114970016665 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970016666 catalytic loop [active] 1114970016667 iron binding site [ion binding]; other site 1114970016668 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1114970016669 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1114970016670 [2Fe-2S] cluster binding site [ion binding]; other site 1114970016671 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1114970016672 putative alpha subunit interface [polypeptide binding]; other site 1114970016673 putative active site [active] 1114970016674 putative substrate binding site [chemical binding]; other site 1114970016675 Fe binding site [ion binding]; other site 1114970016676 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1114970016677 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1114970016678 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1114970016679 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970016680 triacylglycerol lipase; Region: PLN02872 1114970016681 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1114970016682 Ligand Binding Site [chemical binding]; other site 1114970016683 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1114970016684 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1114970016685 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 1114970016686 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114970016687 Cysteine-rich domain; Region: CCG; pfam02754 1114970016688 Cysteine-rich domain; Region: CCG; pfam02754 1114970016689 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1114970016690 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1114970016691 putative active site [active] 1114970016692 putative FMN binding site [chemical binding]; other site 1114970016693 putative substrate binding site [chemical binding]; other site 1114970016694 putative catalytic residue [active] 1114970016695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016696 Heme NO binding; Region: HNOB; cl15268 1114970016697 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1114970016698 active site 1114970016699 dimer interface [polypeptide binding]; other site 1114970016700 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 1114970016701 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 1114970016702 Archaeal ATPase; Region: Arch_ATPase; pfam01637 1114970016703 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970016704 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1114970016705 conserved cys residue [active] 1114970016706 NMT1-like family; Region: NMT1_2; cl15260 1114970016707 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1114970016708 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1114970016709 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 1114970016710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016711 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970016712 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114970016713 active site 1114970016714 Protein of unknown function (DUF971); Region: DUF971; cl01414 1114970016715 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 1114970016716 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1114970016717 substrate binding pocket [chemical binding]; other site 1114970016718 active site 1114970016719 iron coordination sites [ion binding]; other site 1114970016720 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970016721 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1114970016722 conserved cys residue [active] 1114970016723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970016724 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1114970016725 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1114970016726 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1114970016727 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1114970016728 NMT1-like family; Region: NMT1_2; cl15260 1114970016729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970016730 dimer interface [polypeptide binding]; other site 1114970016731 conserved gate region; other site 1114970016732 putative PBP binding loops; other site 1114970016733 ABC-ATPase subunit interface; other site 1114970016734 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1114970016735 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970016736 Walker A/P-loop; other site 1114970016737 ATP binding site [chemical binding]; other site 1114970016738 Q-loop/lid; other site 1114970016739 ABC transporter signature motif; other site 1114970016740 Walker B; other site 1114970016741 D-loop; other site 1114970016742 H-loop/switch region; other site 1114970016743 transcriptional regulator BetI; Validated; Region: PRK00767 1114970016744 Helix-turn-helix domains; Region: HTH; cl00088 1114970016745 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1114970016746 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970016747 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1114970016748 tetrameric interface [polypeptide binding]; other site 1114970016749 NAD binding site [chemical binding]; other site 1114970016750 catalytic residues [active] 1114970016751 choline dehydrogenase; Validated; Region: PRK02106 1114970016752 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970016753 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 1114970016754 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 1114970016755 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 1114970016756 putative transporter; Provisional; Region: PRK10504 1114970016757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970016758 putative substrate translocation pore; other site 1114970016759 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1114970016760 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114970016761 ATP binding site [chemical binding]; other site 1114970016762 Mg++ binding site [ion binding]; other site 1114970016763 motif III; other site 1114970016764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970016765 nucleotide binding region [chemical binding]; other site 1114970016766 ATP-binding site [chemical binding]; other site 1114970016767 DbpA RNA binding domain; Region: DbpA; pfam03880 1114970016768 HI0933-like protein; Region: HI0933_like; pfam03486 1114970016769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016770 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1114970016771 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1114970016772 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1114970016773 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970016774 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970016775 substrate binding pocket [chemical binding]; other site 1114970016776 membrane-bound complex binding site; other site 1114970016777 hinge residues; other site 1114970016778 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114970016779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970016780 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970016781 Coenzyme A binding pocket [chemical binding]; other site 1114970016782 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 1114970016783 Protein of unknown function DUF45; Region: DUF45; cl00636 1114970016784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970016785 active site 1114970016786 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1114970016787 phosphorylation site [posttranslational modification] 1114970016788 intermolecular recognition site; other site 1114970016789 dimerization interface [polypeptide binding]; other site 1114970016790 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970016791 putative active site [active] 1114970016792 heme pocket [chemical binding]; other site 1114970016793 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970016794 metal binding site [ion binding]; metal-binding site 1114970016795 active site 1114970016796 I-site; other site 1114970016797 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970016798 Alginate lyase; Region: Alginate_lyase2; pfam08787 1114970016799 Alginate lyase; Region: Alginate_lyase2; pfam08787 1114970016800 hypothetical protein; Provisional; Region: PRK08185 1114970016801 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1114970016802 intersubunit interface [polypeptide binding]; other site 1114970016803 active site 1114970016804 zinc binding site [ion binding]; other site 1114970016805 Na+ binding site [ion binding]; other site 1114970016806 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 1114970016807 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 1114970016808 Phosphoglycerate kinase; Region: PGK; pfam00162 1114970016809 substrate binding site [chemical binding]; other site 1114970016810 hinge regions; other site 1114970016811 ADP binding site [chemical binding]; other site 1114970016812 catalytic site [active] 1114970016813 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 1114970016814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016815 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1114970016816 transketolase; Reviewed; Region: PRK12753 1114970016817 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1114970016818 TPP-binding site [chemical binding]; other site 1114970016819 dimer interface [polypeptide binding]; other site 1114970016820 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1114970016821 PYR/PP interface [polypeptide binding]; other site 1114970016822 dimer interface [polypeptide binding]; other site 1114970016823 TPP binding site [chemical binding]; other site 1114970016824 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114970016825 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970016826 putative DNA binding site [nucleotide binding]; other site 1114970016827 dimerization interface [polypeptide binding]; other site 1114970016828 putative Zn2+ binding site [ion binding]; other site 1114970016829 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114970016830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970016831 S-adenosylmethionine binding site [chemical binding]; other site 1114970016832 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1114970016833 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1114970016834 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1114970016835 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1114970016836 LysE type translocator; Region: LysE; cl00565 1114970016837 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1114970016838 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1114970016839 nucleotide binding pocket [chemical binding]; other site 1114970016840 K-X-D-G motif; other site 1114970016841 catalytic site [active] 1114970016842 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1114970016843 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1114970016844 Cytochrome C'; Region: Cytochrom_C_2; cl01610 1114970016845 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1114970016846 MltA specific insert domain; Region: MltA; cl08398 1114970016847 3D domain; Region: 3D; cl01439 1114970016848 MAPEG family; Region: MAPEG; cl09190 1114970016849 EamA-like transporter family; Region: EamA; cl01037 1114970016850 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114970016851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970016852 putative substrate translocation pore; other site 1114970016853 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1114970016854 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1114970016855 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1114970016856 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1114970016857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016858 oligomerization interface [polypeptide binding]; other site 1114970016859 active site 1114970016860 NAD+ binding site [chemical binding]; other site 1114970016861 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 1114970016862 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1114970016863 FAD binding site [chemical binding]; other site 1114970016864 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970016865 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970016866 substrate binding pocket [chemical binding]; other site 1114970016867 membrane-bound complex binding site; other site 1114970016868 hinge residues; other site 1114970016869 helicase 45; Provisional; Region: PTZ00424 1114970016870 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114970016871 ATP binding site [chemical binding]; other site 1114970016872 Mg++ binding site [ion binding]; other site 1114970016873 motif III; other site 1114970016874 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970016875 nucleotide binding region [chemical binding]; other site 1114970016876 ATP-binding site [chemical binding]; other site 1114970016877 YceI-like domain; Region: YceI; cl01001 1114970016878 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1114970016879 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1114970016880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016881 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 1114970016882 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970016883 inhibitor-cofactor binding pocket; inhibition site 1114970016884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970016885 catalytic residue [active] 1114970016886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 1114970016887 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1114970016888 Haemolysin-III related; Region: HlyIII; cl03831 1114970016889 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970016890 Helix-turn-helix domains; Region: HTH; cl00088 1114970016891 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 1114970016892 putative dimerization interface [polypeptide binding]; other site 1114970016893 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 1114970016894 Malonate transporter MadL subunit; Region: MadL; cl04273 1114970016895 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1114970016896 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114970016897 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913 1114970016898 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114970016899 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114970016900 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 1114970016901 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1114970016902 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1114970016903 Helix-turn-helix domains; Region: HTH; cl00088 1114970016904 dimerization interface [polypeptide binding]; other site 1114970016905 putative DNA binding site [nucleotide binding]; other site 1114970016906 putative Zn2+ binding site [ion binding]; other site 1114970016907 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1114970016908 active site 1114970016909 NTP binding site [chemical binding]; other site 1114970016910 metal binding triad [ion binding]; metal-binding site 1114970016911 antibiotic binding site [chemical binding]; other site 1114970016912 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1114970016913 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1114970016914 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1114970016915 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970016916 putative binding surface; other site 1114970016917 active site 1114970016918 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1114970016919 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1114970016920 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970016921 putative binding surface; other site 1114970016922 active site 1114970016923 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970016924 putative binding surface; other site 1114970016925 active site 1114970016926 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1114970016927 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1114970016928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970016929 ATP binding site [chemical binding]; other site 1114970016930 Mg2+ binding site [ion binding]; other site 1114970016931 G-X-G motif; other site 1114970016932 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1114970016933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970016934 active site 1114970016935 phosphorylation site [posttranslational modification] 1114970016936 intermolecular recognition site; other site 1114970016937 dimerization interface [polypeptide binding]; other site 1114970016938 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1114970016939 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970016940 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970016941 dimer interface [polypeptide binding]; other site 1114970016942 putative CheW interface [polypeptide binding]; other site 1114970016943 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1114970016944 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970016945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970016946 active site 1114970016947 phosphorylation site [posttranslational modification] 1114970016948 intermolecular recognition site; other site 1114970016949 dimerization interface [polypeptide binding]; other site 1114970016950 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970016951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970016952 active site 1114970016953 phosphorylation site [posttranslational modification] 1114970016954 intermolecular recognition site; other site 1114970016955 dimerization interface [polypeptide binding]; other site 1114970016956 glutathione synthetase; Provisional; Region: PRK05246 1114970016957 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1114970016958 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970016959 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1114970016960 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 1114970016961 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1114970016962 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970016963 active site 1114970016964 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1114970016965 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114970016966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016967 dihydroorotase; Validated; Region: pyrC; PRK09357 1114970016968 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1114970016969 active site 1114970016970 TM2 domain; Region: TM2; cl00984 1114970016971 TM2 domain; Region: TM2; cl00984 1114970016972 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114970016973 NlpC/P60 family; Region: NLPC_P60; cl11438 1114970016974 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1114970016975 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1114970016976 Walker A motif; other site 1114970016977 ATP binding site [chemical binding]; other site 1114970016978 Walker B motif; other site 1114970016979 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1114970016980 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970016981 catalytic residue [active] 1114970016982 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1114970016983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016984 YGGT family; Region: YGGT; cl00508 1114970016985 YGGT family; Region: YGGT; cl00508 1114970016986 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 1114970016987 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1114970016988 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970016989 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1114970016990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970016991 S-adenosylmethionine binding site [chemical binding]; other site 1114970016992 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 1114970016993 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1114970016994 active site 1114970016995 dimerization interface [polypeptide binding]; other site 1114970016996 HemN family oxidoreductase; Provisional; Region: PRK05660 1114970016997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970016998 FeS/SAM binding site; other site 1114970016999 HemN C-terminal domain; Region: HemN_C; pfam06969 1114970017000 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 1114970017001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970017002 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1114970017003 ThiS interaction site; other site 1114970017004 putative active site [active] 1114970017005 tetramer interface [polypeptide binding]; other site 1114970017006 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1114970017007 thiS-thiF/thiG interaction site; other site 1114970017008 Protein of unknown function (DUF423); Region: DUF423; cl01008 1114970017009 Transglycosylase; Region: Transgly; cl07896 1114970017010 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1114970017011 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1114970017012 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970017013 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970017014 DNA binding residues [nucleotide binding] 1114970017015 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1114970017016 FtsX-like permease family; Region: FtsX; cl15850 1114970017017 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1114970017018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017019 Walker A/P-loop; other site 1114970017020 ATP binding site [chemical binding]; other site 1114970017021 Q-loop/lid; other site 1114970017022 ABC transporter signature motif; other site 1114970017023 Walker B; other site 1114970017024 D-loop; other site 1114970017025 H-loop/switch region; other site 1114970017026 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1114970017027 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1114970017028 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1114970017029 P loop; other site 1114970017030 GTP binding site [chemical binding]; other site 1114970017031 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114970017032 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1114970017033 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114970017034 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114970017035 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114970017036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970017037 S-adenosylmethionine binding site [chemical binding]; other site 1114970017038 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1114970017039 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1114970017040 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1114970017041 active site residue [active] 1114970017042 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1114970017043 active site residue [active] 1114970017044 Helix-turn-helix domains; Region: HTH; cl00088 1114970017045 Bacterial transcriptional repressor; Region: TetR; pfam13972 1114970017046 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1114970017047 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1114970017048 NAD(P) binding site [chemical binding]; other site 1114970017049 catalytic residues [active] 1114970017050 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 1114970017051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970017052 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1114970017053 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970017054 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1114970017055 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1114970017056 active site 1114970017057 (T/H)XGH motif; other site 1114970017058 ferredoxin; Validated; Region: PRK07118 1114970017059 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1114970017060 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1114970017061 DNA binding site [nucleotide binding] 1114970017062 catalytic residue [active] 1114970017063 H2TH interface [polypeptide binding]; other site 1114970017064 putative catalytic residues [active] 1114970017065 turnover-facilitating residue; other site 1114970017066 intercalation triad [nucleotide binding]; other site 1114970017067 8OG recognition residue [nucleotide binding]; other site 1114970017068 putative reading head residues; other site 1114970017069 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1114970017070 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1114970017071 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1114970017072 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114970017073 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1114970017074 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1114970017075 putative RNA binding site [nucleotide binding]; other site 1114970017076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970017077 S-adenosylmethionine binding site [chemical binding]; other site 1114970017078 Dehydratase family; Region: ILVD_EDD; cl00340 1114970017079 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114970017080 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1114970017081 folate binding site [chemical binding]; other site 1114970017082 NADP+ binding site [chemical binding]; other site 1114970017083 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 1114970017084 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017085 G1 box; other site 1114970017086 GTP/Mg2+ binding site [chemical binding]; other site 1114970017087 G2 box; other site 1114970017088 Switch I region; other site 1114970017089 G3 box; other site 1114970017090 Switch II region; other site 1114970017091 G4 box; other site 1114970017092 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 1114970017093 Protein of unknown function (DUF523); Region: DUF523; cl00733 1114970017094 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 1114970017095 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1114970017096 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 1114970017097 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114970017098 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114970017099 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114970017100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970017101 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114970017102 Walker A motif; other site 1114970017103 ATP binding site [chemical binding]; other site 1114970017104 Walker B motif; other site 1114970017105 arginine finger; other site 1114970017106 Helix-turn-helix domains; Region: HTH; cl00088 1114970017107 HrpZ; Region: Hairpins; pfam04877 1114970017108 Type III secretion needle MxiH like; Region: MxiH; cl09641 1114970017109 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1114970017110 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 1114970017111 HrpF protein; Region: HrpF; pfam06266 1114970017112 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 1114970017113 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970017114 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970017115 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970017116 Tir chaperone protein (CesT) family; Region: CesT; cl08444 1114970017117 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 1114970017118 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1114970017119 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1114970017120 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1114970017121 FliP family; Region: FliP; cl00593 1114970017122 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 1114970017123 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1114970017124 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 1114970017125 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1114970017126 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017127 Walker A motif; other site 1114970017128 ATP binding site [chemical binding]; other site 1114970017129 Walker B motif; other site 1114970017130 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1114970017131 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1114970017132 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 1114970017133 FHIPEP family; Region: FHIPEP; pfam00771 1114970017134 HrpJ-like domain; Region: HrpJ; cl15454 1114970017135 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1114970017136 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970017137 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970017138 DNA binding residues [nucleotide binding] 1114970017139 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1114970017140 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970017141 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1114970017142 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114970017143 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1114970017144 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1114970017145 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970017146 catalytic residue [active] 1114970017147 Tir chaperone protein (CesT) family; Region: CesT; cl08444 1114970017148 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1114970017149 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1114970017150 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1114970017151 active site 1114970017152 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970017153 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970017154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970017155 dimer interface [polypeptide binding]; other site 1114970017156 conserved gate region; other site 1114970017157 putative PBP binding loops; other site 1114970017158 ABC-ATPase subunit interface; other site 1114970017159 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 1114970017160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970017161 dimer interface [polypeptide binding]; other site 1114970017162 conserved gate region; other site 1114970017163 putative PBP binding loops; other site 1114970017164 ABC-ATPase subunit interface; other site 1114970017165 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1114970017166 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017167 Walker A/P-loop; other site 1114970017168 ATP binding site [chemical binding]; other site 1114970017169 Q-loop/lid; other site 1114970017170 ABC transporter signature motif; other site 1114970017171 Walker B; other site 1114970017172 D-loop; other site 1114970017173 H-loop/switch region; other site 1114970017174 TOBE domain; Region: TOBE_2; cl01440 1114970017175 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1114970017176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970017177 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1114970017178 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970017179 putative aminotransferase; Validated; Region: PRK07480 1114970017180 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970017181 inhibitor-cofactor binding pocket; inhibition site 1114970017182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970017183 catalytic residue [active] 1114970017184 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1114970017185 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970017186 Peptidase C26; Region: Peptidase_C26; pfam07722 1114970017187 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1114970017188 catalytic triad [active] 1114970017189 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1114970017190 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970017191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970017192 Helix-turn-helix domains; Region: HTH; cl00088 1114970017193 TOBE domain; Region: TOBE_2; cl01440 1114970017194 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1114970017195 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1114970017196 Walker A/P-loop; other site 1114970017197 ATP binding site [chemical binding]; other site 1114970017198 Q-loop/lid; other site 1114970017199 ABC transporter signature motif; other site 1114970017200 Walker B; other site 1114970017201 D-loop; other site 1114970017202 H-loop/switch region; other site 1114970017203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970017204 dimer interface [polypeptide binding]; other site 1114970017205 conserved gate region; other site 1114970017206 putative PBP binding loops; other site 1114970017207 ABC-ATPase subunit interface; other site 1114970017208 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1114970017209 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1114970017210 active site 1114970017211 dimer interface [polypeptide binding]; other site 1114970017212 non-prolyl cis peptide bond; other site 1114970017213 insertion regions; other site 1114970017214 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1114970017215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970017216 substrate binding pocket [chemical binding]; other site 1114970017217 membrane-bound complex binding site; other site 1114970017218 hinge residues; other site 1114970017219 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114970017220 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1114970017221 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1114970017222 dimer interface [polypeptide binding]; other site 1114970017223 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1114970017224 catalytic triad [active] 1114970017225 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1114970017226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970017227 putative substrate translocation pore; other site 1114970017228 prephenate dehydrogenase; Provisional; Region: PRK08655 1114970017229 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1114970017230 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1114970017231 glutamine binding [chemical binding]; other site 1114970017232 catalytic triad [active] 1114970017233 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1114970017234 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114970017235 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1114970017236 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1114970017237 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970017238 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970017239 catalytic residue [active] 1114970017240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970017241 S-adenosylmethionine binding site [chemical binding]; other site 1114970017242 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1114970017243 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1114970017244 active site 1114970017245 NTP binding site [chemical binding]; other site 1114970017246 metal binding triad [ion binding]; metal-binding site 1114970017247 antibiotic binding site [chemical binding]; other site 1114970017248 Protein of unknown function DUF86; Region: DUF86; cl01031 1114970017249 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970017250 N-acetylglutamate synthase; Validated; Region: PRK05279 1114970017251 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1114970017252 putative feedback inhibition sensing region; other site 1114970017253 putative nucleotide binding site [chemical binding]; other site 1114970017254 putative substrate binding site [chemical binding]; other site 1114970017255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970017256 Coenzyme A binding pocket [chemical binding]; other site 1114970017257 acetylornithine deacetylase; Provisional; Region: PRK05111 1114970017258 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1114970017259 metal binding site [ion binding]; metal-binding site 1114970017260 putative dimer interface [polypeptide binding]; other site 1114970017261 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1114970017262 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1114970017263 putative active site [active] 1114970017264 putative metal binding residues [ion binding]; other site 1114970017265 signature motif; other site 1114970017266 putative triphosphate binding site [ion binding]; other site 1114970017267 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970017268 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970017269 putative DNA binding site [nucleotide binding]; other site 1114970017270 putative Zn2+ binding site [ion binding]; other site 1114970017271 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970017272 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1114970017273 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017274 Walker A motif; other site 1114970017275 ATP binding site [chemical binding]; other site 1114970017276 Walker B motif; other site 1114970017277 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1114970017278 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1114970017279 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1114970017280 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 1114970017281 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1114970017282 lipoyl attachment site [posttranslational modification]; other site 1114970017283 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1114970017284 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114970017285 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1114970017286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970017287 dimer interface [polypeptide binding]; other site 1114970017288 conserved gate region; other site 1114970017289 putative PBP binding loops; other site 1114970017290 ABC-ATPase subunit interface; other site 1114970017291 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970017292 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114970017293 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 1114970017294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970017295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970017296 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1114970017297 proline aminopeptidase P II; Provisional; Region: PRK10879 1114970017298 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 1114970017299 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1114970017300 active site 1114970017301 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1114970017302 TIGR02449 family protein; Region: TIGR02449 1114970017303 Cell division protein ZapA; Region: ZapA; cl01146 1114970017304 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 1114970017305 EVE domain; Region: EVE; cl00728 1114970017306 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1114970017307 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970017308 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114970017309 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1114970017310 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017311 Walker A/P-loop; other site 1114970017312 ATP binding site [chemical binding]; other site 1114970017313 Q-loop/lid; other site 1114970017314 ABC transporter signature motif; other site 1114970017315 Walker B; other site 1114970017316 D-loop; other site 1114970017317 H-loop/switch region; other site 1114970017318 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017319 Walker A/P-loop; other site 1114970017320 ATP binding site [chemical binding]; other site 1114970017321 Q-loop/lid; other site 1114970017322 ABC transporter signature motif; other site 1114970017323 Walker B; other site 1114970017324 D-loop; other site 1114970017325 H-loop/switch region; other site 1114970017326 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1114970017327 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114970017328 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114970017329 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114970017330 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1114970017331 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114970017332 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1114970017333 NAD(P) binding site [chemical binding]; other site 1114970017334 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1114970017335 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1114970017336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970017337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970017338 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1114970017339 putative active site pocket [active] 1114970017340 dimerization interface [polypeptide binding]; other site 1114970017341 putative catalytic residue [active] 1114970017342 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1114970017343 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970017344 catalytic loop [active] 1114970017345 iron binding site [ion binding]; other site 1114970017346 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1114970017347 FAD binding pocket [chemical binding]; other site 1114970017348 FAD binding motif [chemical binding]; other site 1114970017349 phosphate binding motif [ion binding]; other site 1114970017350 beta-alpha-beta structure motif; other site 1114970017351 NAD binding pocket [chemical binding]; other site 1114970017352 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1114970017353 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1114970017354 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1114970017355 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1114970017356 RNA binding site [nucleotide binding]; other site 1114970017357 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1114970017358 multimer interface [polypeptide binding]; other site 1114970017359 Walker A motif; other site 1114970017360 ATP binding site [chemical binding]; other site 1114970017361 Walker B motif; other site 1114970017362 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114970017363 catalytic residues [active] 1114970017364 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970017365 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970017366 DNA-binding site [nucleotide binding]; DNA binding site 1114970017367 FCD domain; Region: FCD; cl11656 1114970017368 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970017369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970017370 substrate binding pocket [chemical binding]; other site 1114970017371 membrane-bound complex binding site; other site 1114970017372 hinge residues; other site 1114970017373 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970017374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970017375 dimer interface [polypeptide binding]; other site 1114970017376 conserved gate region; other site 1114970017377 putative PBP binding loops; other site 1114970017378 ABC-ATPase subunit interface; other site 1114970017379 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970017380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970017381 dimer interface [polypeptide binding]; other site 1114970017382 conserved gate region; other site 1114970017383 putative PBP binding loops; other site 1114970017384 ABC-ATPase subunit interface; other site 1114970017385 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970017386 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114970017387 Walker A/P-loop; other site 1114970017388 ATP binding site [chemical binding]; other site 1114970017389 Q-loop/lid; other site 1114970017390 ABC transporter signature motif; other site 1114970017391 Walker B; other site 1114970017392 D-loop; other site 1114970017393 H-loop/switch region; other site 1114970017394 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1114970017395 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 1114970017396 polyphosphate kinase; Provisional; Region: PRK05443 1114970017397 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1114970017398 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1114970017399 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1114970017400 putative active site [active] 1114970017401 catalytic site [active] 1114970017402 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1114970017403 putative domain interface [polypeptide binding]; other site 1114970017404 putative active site [active] 1114970017405 catalytic site [active] 1114970017406 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1114970017407 dimer interface [polypeptide binding]; other site 1114970017408 allosteric magnesium binding site [ion binding]; other site 1114970017409 active site 1114970017410 aspartate-rich active site metal binding site; other site 1114970017411 Schiff base residues; other site 1114970017412 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114970017413 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1114970017414 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1114970017415 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1114970017416 conserved cys residue [active] 1114970017417 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1114970017418 Cytochrome c; Region: Cytochrom_C; cl11414 1114970017419 Iron permease FTR1 family; Region: FTR1; cl00475 1114970017420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1114970017421 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1114970017422 putative dimer interface [polypeptide binding]; other site 1114970017423 TolB amino-terminal domain; Region: TolB_N; cl00639 1114970017424 TolB amino-terminal domain; Region: TolB_N; cl00639 1114970017425 LysE type translocator; Region: LysE; cl00565 1114970017426 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114970017427 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1114970017428 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017429 Walker A/P-loop; other site 1114970017430 ATP binding site [chemical binding]; other site 1114970017431 Q-loop/lid; other site 1114970017432 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114970017433 ABC transporter signature motif; other site 1114970017434 Walker B; other site 1114970017435 D-loop; other site 1114970017436 ABC transporter; Region: ABC_tran_2; pfam12848 1114970017437 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114970017438 Protein of unknown function (DUF2390); Region: DUF2390; cl02376 1114970017439 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1114970017440 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1114970017441 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1114970017442 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; cl11478 1114970017443 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1114970017444 hemY protein; Region: hemY_coli; TIGR00540 1114970017445 HemY protein N-terminus; Region: HemY_N; pfam07219 1114970017446 uroporphyrinogen-III synthase; Validated; Region: PRK05752 1114970017447 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1114970017448 active site 1114970017449 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1114970017450 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1114970017451 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1114970017452 domain interfaces; other site 1114970017453 active site 1114970017454 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1114970017455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970017456 active site 1114970017457 phosphorylation site [posttranslational modification] 1114970017458 intermolecular recognition site; other site 1114970017459 LytTr DNA-binding domain; Region: LytTR; cl04498 1114970017460 argininosuccinate lyase; Provisional; Region: PRK00855 1114970017461 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1114970017462 active sites [active] 1114970017463 tetramer interface [polypeptide binding]; other site 1114970017464 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970017465 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1114970017466 C-terminal domain interface [polypeptide binding]; other site 1114970017467 GSH binding site (G-site) [chemical binding]; other site 1114970017468 dimer interface [polypeptide binding]; other site 1114970017469 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1114970017470 N-terminal domain interface [polypeptide binding]; other site 1114970017471 dimer interface [polypeptide binding]; other site 1114970017472 substrate binding pocket (H-site) [chemical binding]; other site 1114970017473 Phosphate-starvation-inducible E; Region: PsiE; cl01264 1114970017474 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1114970017475 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1114970017476 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1114970017477 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1114970017478 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1114970017479 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114970017480 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 1114970017481 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cd00503 1114970017482 putative iron binding site [ion binding]; other site 1114970017483 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1114970017484 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1114970017485 active site 1114970017486 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970017487 substrate binding site [chemical binding]; other site 1114970017488 catalytic residues [active] 1114970017489 dimer interface [polypeptide binding]; other site 1114970017490 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1114970017491 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114970017492 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114970017493 GAF domain; Region: GAF; cl15785 1114970017494 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1114970017495 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1114970017496 active site 1114970017497 DNA binding site [nucleotide binding] 1114970017498 Int/Topo IB signature motif; other site 1114970017499 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1114970017500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970017501 motif II; other site 1114970017502 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1114970017503 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1114970017504 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1114970017505 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1114970017506 Membrane fusogenic activity; Region: BMFP; cl01115 1114970017507 BRO family, N-terminal domain; Region: Bro-N; cl10591 1114970017508 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1114970017509 Membrane fusogenic activity; Region: BMFP; cl01115 1114970017510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970017511 ATP binding site [chemical binding]; other site 1114970017512 Mg2+ binding site [ion binding]; other site 1114970017513 G-X-G motif; other site 1114970017514 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970017515 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970017516 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 1114970017517 Integrase core domain; Region: rve; cl01316 1114970017518 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970017519 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970017520 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1114970017521 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1114970017522 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017523 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1114970017524 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1114970017525 active site 1114970017526 catalytic residues [active] 1114970017527 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1114970017528 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970017529 dimerization interface [polypeptide binding]; other site 1114970017530 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970017531 dimer interface [polypeptide binding]; other site 1114970017532 putative CheW interface [polypeptide binding]; other site 1114970017533 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970017534 Helix-turn-helix domains; Region: HTH; cl00088 1114970017535 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970017536 dimerization interface [polypeptide binding]; other site 1114970017537 substrate binding pocket [chemical binding]; other site 1114970017538 multidrug efflux protein NorA; Provisional; Region: PRK00187 1114970017539 MatE; Region: MatE; cl10513 1114970017540 MatE; Region: MatE; cl10513 1114970017541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970017542 metal binding site [ion binding]; metal-binding site 1114970017543 active site 1114970017544 I-site; other site 1114970017545 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970017546 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1114970017547 Family description; Region: UvrD_C_2; cl15862 1114970017548 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970017549 active site 1114970017550 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1114970017551 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114970017552 Cytochrome c; Region: Cytochrom_C; cl11414 1114970017553 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1114970017554 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970017555 non-specific DNA binding site [nucleotide binding]; other site 1114970017556 salt bridge; other site 1114970017557 sequence-specific DNA binding site [nucleotide binding]; other site 1114970017558 Cupin domain; Region: Cupin_2; cl09118 1114970017559 alanine racemase; Reviewed; Region: dadX; PRK03646 1114970017560 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1114970017561 active site 1114970017562 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970017563 substrate binding site [chemical binding]; other site 1114970017564 catalytic residues [active] 1114970017565 dimer interface [polypeptide binding]; other site 1114970017566 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1114970017567 homotrimer interaction site [polypeptide binding]; other site 1114970017568 putative active site [active] 1114970017569 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1114970017570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970017571 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1114970017572 Helix-turn-helix domains; Region: HTH; cl00088 1114970017573 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970017574 Flagellin N-methylase; Region: FliB; cl00497 1114970017575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970017576 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970017577 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 1114970017578 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970017579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970017580 DNA-binding site [nucleotide binding]; DNA binding site 1114970017581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970017582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970017583 homodimer interface [polypeptide binding]; other site 1114970017584 catalytic residue [active] 1114970017585 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1114970017586 PLD-like domain; Region: PLDc_2; pfam13091 1114970017587 putative active site [active] 1114970017588 catalytic site [active] 1114970017589 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1114970017590 putative active site [active] 1114970017591 catalytic site [active] 1114970017592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970017593 putative substrate translocation pore; other site 1114970017594 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970017595 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1114970017596 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1114970017597 NAD(P) binding site [chemical binding]; other site 1114970017598 catalytic residues [active] 1114970017599 Cupin domain; Region: Cupin_2; cl09118 1114970017600 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 1114970017601 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 1114970017602 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1114970017603 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1114970017604 peptide binding site [polypeptide binding]; other site 1114970017605 hypothetical protein; Reviewed; Region: PRK00024 1114970017606 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1114970017607 MPN+ (JAMM) motif; other site 1114970017608 Zinc-binding site [ion binding]; other site 1114970017609 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1114970017610 Flavoprotein; Region: Flavoprotein; cl08021 1114970017611 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 1114970017612 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1114970017613 trimer interface [polypeptide binding]; other site 1114970017614 active site 1114970017615 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1114970017616 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1114970017617 active site 1114970017618 substrate binding site [chemical binding]; other site 1114970017619 metal binding site [ion binding]; metal-binding site 1114970017620 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1114970017621 feedback inhibition sensing region; other site 1114970017622 homohexameric interface [polypeptide binding]; other site 1114970017623 nucleotide binding site [chemical binding]; other site 1114970017624 N-acetyl-L-glutamate binding site [chemical binding]; other site 1114970017625 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970017626 active site 1114970017627 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1114970017628 putative active site [active] 1114970017629 putative catalytic site [active] 1114970017630 putative DNA binding site [nucleotide binding]; other site 1114970017631 putative phosphate binding site [ion binding]; other site 1114970017632 metal binding site A [ion binding]; metal-binding site 1114970017633 putative AP binding site [nucleotide binding]; other site 1114970017634 putative metal binding site B [ion binding]; other site 1114970017635 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1114970017636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296; cl15800 1114970017637 ribonuclease PH; Reviewed; Region: rph; PRK00173 1114970017638 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1114970017639 hexamer interface [polypeptide binding]; other site 1114970017640 active site 1114970017641 hypothetical protein; Provisional; Region: PRK11820 1114970017642 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1114970017643 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1114970017644 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1114970017645 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1114970017646 catalytic site [active] 1114970017647 G-X2-G-X-G-K; other site 1114970017648 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 1114970017649 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1114970017650 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114970017651 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1114970017652 synthetase active site [active] 1114970017653 NTP binding site [chemical binding]; other site 1114970017654 metal binding site [ion binding]; metal-binding site 1114970017655 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1114970017656 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1114970017657 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114970017658 homotrimer interaction site [polypeptide binding]; other site 1114970017659 putative active site [active] 1114970017660 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970017661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970017662 NAD(P) binding site [chemical binding]; other site 1114970017663 active site 1114970017664 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114970017665 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1114970017666 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1114970017667 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1114970017668 Helix-turn-helix domains; Region: HTH; cl00088 1114970017669 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1114970017670 dimerization interface [polypeptide binding]; other site 1114970017671 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1114970017672 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1114970017673 generic binding surface II; other site 1114970017674 ssDNA binding site; other site 1114970017675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970017676 ATP binding site [chemical binding]; other site 1114970017677 putative Mg++ binding site [ion binding]; other site 1114970017678 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970017679 nucleotide binding region [chemical binding]; other site 1114970017680 ATP-binding site [chemical binding]; other site 1114970017681 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1114970017682 putative deacylase active site [active] 1114970017683 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1114970017684 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 1114970017685 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114970017686 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017687 Walker A/P-loop; other site 1114970017688 ATP binding site [chemical binding]; other site 1114970017689 Q-loop/lid; other site 1114970017690 ABC transporter signature motif; other site 1114970017691 Walker B; other site 1114970017692 D-loop; other site 1114970017693 H-loop/switch region; other site 1114970017694 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1114970017695 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1114970017696 active site 1114970017697 ATP binding site [chemical binding]; other site 1114970017698 substrate binding site [chemical binding]; other site 1114970017699 activation loop (A-loop); other site 1114970017700 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1114970017701 metal ion-dependent adhesion site (MIDAS); other site 1114970017702 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1114970017703 Protein phosphatase 2C; Region: PP2C; pfam00481 1114970017704 active site 1114970017705 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 1114970017706 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1114970017707 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1114970017708 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1114970017709 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1114970017710 hypothetical protein; Provisional; Region: PRK07033 1114970017711 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1114970017712 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970017713 ligand binding site [chemical binding]; other site 1114970017714 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1114970017715 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1114970017716 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 1114970017717 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1114970017718 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1114970017719 phosphopeptide binding site; other site 1114970017720 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1114970017721 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1114970017722 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1114970017723 Protein of unknown function (DUF770); Region: DUF770; cl01402 1114970017724 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1114970017725 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1114970017726 Protein of unknown function (DUF796); Region: DUF796; cl01226 1114970017727 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1114970017728 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1114970017729 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1114970017730 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 1114970017731 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 1114970017732 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1114970017733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970017734 Walker A motif; other site 1114970017735 ATP binding site [chemical binding]; other site 1114970017736 Walker B motif; other site 1114970017737 arginine finger; other site 1114970017738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970017739 Walker A motif; other site 1114970017740 ATP binding site [chemical binding]; other site 1114970017741 Walker B motif; other site 1114970017742 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1114970017743 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1114970017744 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1114970017745 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970017746 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 1114970017747 PAAR motif; Region: PAAR_motif; cl15808 1114970017748 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970017749 RHS Repeat; Region: RHS_repeat; cl11982 1114970017750 RHS Repeat; Region: RHS_repeat; cl11982 1114970017751 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970017752 RHS Repeat; Region: RHS_repeat; cl11982 1114970017753 RHS Repeat; Region: RHS_repeat; cl11982 1114970017754 RHS Repeat; Region: RHS_repeat; cl11982 1114970017755 RHS Repeat; Region: RHS_repeat; cl11982 1114970017756 RHS Repeat; Region: RHS_repeat; cl11982 1114970017757 RHS Repeat; Region: RHS_repeat; cl11982 1114970017758 RHS protein; Region: RHS; pfam03527 1114970017759 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970017760 RES domain; Region: RES; cl02411 1114970017761 PAAR motif; Region: PAAR_motif; cl15808 1114970017762 RHS Repeat; Region: RHS_repeat; cl11982 1114970017763 RHS Repeat; Region: RHS_repeat; cl11982 1114970017764 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970017765 RHS Repeat; Region: RHS_repeat; cl11982 1114970017766 RHS Repeat; Region: RHS_repeat; cl11982 1114970017767 RHS Repeat; Region: RHS_repeat; cl11982 1114970017768 RHS Repeat; Region: RHS_repeat; cl11982 1114970017769 RHS Repeat; Region: RHS_repeat; cl11982 1114970017770 RHS Repeat; Region: RHS_repeat; cl11982 1114970017771 RHS Repeat; Region: RHS_repeat; cl11982 1114970017772 RHS protein; Region: RHS; pfam03527 1114970017773 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970017774 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 1114970017775 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1114970017776 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1114970017777 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1114970017778 active site 1114970017779 ATP binding site [chemical binding]; other site 1114970017780 substrate binding site [chemical binding]; other site 1114970017781 activation loop (A-loop); other site 1114970017782 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1114970017783 active site 1114970017784 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1114970017785 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1114970017786 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1114970017787 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1114970017788 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1114970017789 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1114970017790 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1114970017791 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 1114970017792 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1114970017793 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1114970017794 phosphopeptide binding site; other site 1114970017795 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1114970017796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970017797 Walker A motif; other site 1114970017798 ATP binding site [chemical binding]; other site 1114970017799 Walker B motif; other site 1114970017800 arginine finger; other site 1114970017801 Helix-turn-helix domains; Region: HTH; cl00088 1114970017802 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1114970017803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970017804 Walker A motif; other site 1114970017805 ATP binding site [chemical binding]; other site 1114970017806 Walker B motif; other site 1114970017807 arginine finger; other site 1114970017808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970017809 Walker A motif; other site 1114970017810 ATP binding site [chemical binding]; other site 1114970017811 Walker B motif; other site 1114970017812 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1114970017813 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 1114970017814 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1114970017815 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 1114970017816 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1114970017817 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1114970017818 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1114970017819 Protein of unknown function (DUF770); Region: DUF770; cl01402 1114970017820 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1114970017821 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1114970017822 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1114970017823 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1114970017824 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1114970017825 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970017826 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1114970017827 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 1114970017828 active site flap/lid [active] 1114970017829 nucleophilic elbow; other site 1114970017830 catalytic triad [active] 1114970017831 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1114970017832 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 1114970017833 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1114970017834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970017835 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970017836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970017837 DNA-binding site [nucleotide binding]; DNA binding site 1114970017838 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970017839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970017840 homodimer interface [polypeptide binding]; other site 1114970017841 catalytic residue [active] 1114970017842 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1114970017843 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114970017844 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970017845 Coenzyme A binding pocket [chemical binding]; other site 1114970017846 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114970017847 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970017848 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114970017849 OTU-like cysteine protease; Region: OTU; cl14910 1114970017850 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1114970017851 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1114970017852 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970017853 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970017854 substrate binding pocket [chemical binding]; other site 1114970017855 membrane-bound complex binding site; other site 1114970017856 hinge residues; other site 1114970017857 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970017858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970017859 dimer interface [polypeptide binding]; other site 1114970017860 conserved gate region; other site 1114970017861 putative PBP binding loops; other site 1114970017862 ABC-ATPase subunit interface; other site 1114970017863 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1114970017864 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1114970017865 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1114970017866 active site 1114970017867 catalytic residues [active] 1114970017868 metal binding site [ion binding]; metal-binding site 1114970017869 homodimer binding site [polypeptide binding]; other site 1114970017870 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970017871 carboxyltransferase (CT) interaction site; other site 1114970017872 biotinylation site [posttranslational modification]; other site 1114970017873 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1114970017874 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970017875 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114970017876 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1114970017877 Helix-turn-helix domains; Region: HTH; cl00088 1114970017878 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1114970017879 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1114970017880 putative dimerization interface [polypeptide binding]; other site 1114970017881 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1114970017882 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114970017883 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114970017884 putative active site [active] 1114970017885 PAS fold; Region: PAS_3; pfam08447 1114970017886 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1114970017887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970017888 PAS domain; Region: PAS_9; pfam13426 1114970017889 putative active site [active] 1114970017890 heme pocket [chemical binding]; other site 1114970017891 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970017892 metal binding site [ion binding]; metal-binding site 1114970017893 active site 1114970017894 I-site; other site 1114970017895 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970017896 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1114970017897 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017898 Family description; Region: UvrD_C_2; cl15862 1114970017899 Tim44-like domain; Region: Tim44; cl09208 1114970017900 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1114970017901 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1114970017902 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1114970017903 pyridoxamine kinase; Validated; Region: PRK05756 1114970017904 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1114970017905 pyridoxal binding site [chemical binding]; other site 1114970017906 dimer interface [polypeptide binding]; other site 1114970017907 ATP binding site [chemical binding]; other site 1114970017908 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1114970017909 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017910 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1114970017911 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 1114970017912 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1114970017913 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017914 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1114970017915 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 1114970017916 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1114970017917 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114970017918 Walker A/P-loop; other site 1114970017919 ATP binding site [chemical binding]; other site 1114970017920 Q-loop/lid; other site 1114970017921 ABC transporter signature motif; other site 1114970017922 Walker B; other site 1114970017923 D-loop; other site 1114970017924 H-loop/switch region; other site 1114970017925 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1114970017926 ABC-ATPase subunit interface; other site 1114970017927 dimer interface [polypeptide binding]; other site 1114970017928 putative PBP binding regions; other site 1114970017929 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1114970017930 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1114970017931 metal binding site [ion binding]; metal-binding site 1114970017932 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1114970017933 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1114970017934 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1114970017935 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 1114970017936 putative active site [active] 1114970017937 catalytic site [active] 1114970017938 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1114970017939 putative active site [active] 1114970017940 catalytic site [active] 1114970017941 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1114970017942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970017943 S-adenosylmethionine binding site [chemical binding]; other site 1114970017944 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1114970017945 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114970017946 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1114970017947 HflK protein; Region: hflK; TIGR01933 1114970017948 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1114970017949 HflC protein; Region: hflC; TIGR01932 1114970017950 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1114970017951 HflK protein; Region: hflK; TIGR01933 1114970017952 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 1114970017953 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 1114970017954 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970017955 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114970017956 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1114970017957 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1114970017958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970017959 OpgC protein; Region: OpgC_C; cl00792 1114970017960 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970017961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114970017962 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1114970017963 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1114970017964 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970017965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970017966 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1114970017967 NAD(P) binding site [chemical binding]; other site 1114970017968 active site 1114970017969 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1114970017970 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1114970017971 NADP-binding site; other site 1114970017972 homotetramer interface [polypeptide binding]; other site 1114970017973 substrate binding site [chemical binding]; other site 1114970017974 homodimer interface [polypeptide binding]; other site 1114970017975 active site 1114970017976 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1114970017977 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1114970017978 Substrate binding site; other site 1114970017979 Cupin domain; Region: Cupin_2; cl09118 1114970017980 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114970017981 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1114970017982 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 1114970017983 Walker A/P-loop; other site 1114970017984 ATP binding site [chemical binding]; other site 1114970017985 Q-loop/lid; other site 1114970017986 ABC transporter signature motif; other site 1114970017987 Walker B; other site 1114970017988 D-loop; other site 1114970017989 H-loop/switch region; other site 1114970017990 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1114970017991 putative carbohydrate binding site [chemical binding]; other site 1114970017992 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970017993 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970017994 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1114970017995 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970017996 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1114970017997 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970017998 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1114970017999 putative ADP-binding pocket [chemical binding]; other site 1114970018000 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970018001 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1114970018002 putative C-terminal domain interface [polypeptide binding]; other site 1114970018003 putative GSH binding site (G-site) [chemical binding]; other site 1114970018004 putative dimer interface [polypeptide binding]; other site 1114970018005 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1114970018006 putative N-terminal domain interface [polypeptide binding]; other site 1114970018007 putative dimer interface [polypeptide binding]; other site 1114970018008 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970018009 Helix-turn-helix domains; Region: HTH; cl00088 1114970018010 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970018011 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1114970018012 putative effector binding pocket; other site 1114970018013 putative dimerization interface [polypeptide binding]; other site 1114970018014 Sulfatase; Region: Sulfatase; cl10460 1114970018015 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1114970018016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970018017 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1114970018018 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1114970018019 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1114970018020 conserved cys residue [active] 1114970018021 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970018022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970018023 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1114970018024 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1114970018025 dimer interface [polypeptide binding]; other site 1114970018026 ADP-ribose binding site [chemical binding]; other site 1114970018027 active site 1114970018028 nudix motif; other site 1114970018029 metal binding site [ion binding]; metal-binding site 1114970018030 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114970018031 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970018032 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1114970018033 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1114970018034 active site pocket [active] 1114970018035 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1114970018036 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1114970018037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1114970018038 NMT1-like family; Region: NMT1_2; cl15260 1114970018039 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1114970018040 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1114970018041 glutaminase active site [active] 1114970018042 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1114970018043 dimer interface [polypeptide binding]; other site 1114970018044 active site 1114970018045 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1114970018046 dimer interface [polypeptide binding]; other site 1114970018047 active site 1114970018048 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1114970018049 Helix-turn-helix domains; Region: HTH; cl00088 1114970018050 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114970018051 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 1114970018052 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1114970018053 Substrate binding site; other site 1114970018054 Mg++ binding site; other site 1114970018055 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1114970018056 active site 1114970018057 substrate binding site [chemical binding]; other site 1114970018058 CoA binding site [chemical binding]; other site 1114970018059 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1114970018060 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 1114970018061 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 1114970018062 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1114970018063 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1114970018064 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1114970018065 alpha subunit interaction interface [polypeptide binding]; other site 1114970018066 Walker A motif; other site 1114970018067 ATP binding site [chemical binding]; other site 1114970018068 Walker B motif; other site 1114970018069 inhibitor binding site; inhibition site 1114970018070 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1114970018071 ATP synthase; Region: ATP-synt; cl00365 1114970018072 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 1114970018073 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1114970018074 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1114970018075 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1114970018076 beta subunit interaction interface [polypeptide binding]; other site 1114970018077 Walker A motif; other site 1114970018078 ATP binding site [chemical binding]; other site 1114970018079 Walker B motif; other site 1114970018080 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1114970018081 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1114970018082 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1114970018083 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1114970018084 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1114970018085 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1114970018086 ATP synthase A chain; Region: ATP-synt_A; cl00413 1114970018087 ATP synthase I chain; Region: ATP_synt_I; cl09170 1114970018088 ParB-like partition proteins; Region: parB_part; TIGR00180 1114970018089 ParB-like nuclease domain; Region: ParBc; cl02129 1114970018090 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114970018091 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114970018092 Magnesium ion binding site [ion binding]; other site 1114970018093 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114970018094 Magnesium ion binding site [ion binding]; other site 1114970018095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970018096 S-adenosylmethionine binding site [chemical binding]; other site 1114970018097 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1114970018098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970018099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970018100 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1114970018101 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1114970018102 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1114970018103 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1114970018104 G1 box; other site 1114970018105 GTP/Mg2+ binding site [chemical binding]; other site 1114970018106 Switch I region; other site 1114970018107 G2 box; other site 1114970018108 Switch II region; other site 1114970018109 G3 box; other site 1114970018110 G4 box; other site 1114970018111 G5 box; other site 1114970018112 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1114970018113 membrane protein insertase; Provisional; Region: PRK01318 1114970018114 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1114970018115 Ribonuclease P; Region: Ribonuclease_P; cl00457