-- dump date 20120504_151907 -- class Genbank::misc_feature -- table misc_feature_note -- id note 743720000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 743720000002 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 743720000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000004 Walker A motif; other site 743720000005 ATP binding site [chemical binding]; other site 743720000006 Walker B motif; other site 743720000007 arginine finger; other site 743720000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 743720000009 DnaA box-binding interface [nucleotide binding]; other site 743720000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 743720000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 743720000012 putative DNA binding surface [nucleotide binding]; other site 743720000013 dimer interface [polypeptide binding]; other site 743720000014 beta-clamp/clamp loader binding surface; other site 743720000015 beta-clamp/translesion DNA polymerase binding surface; other site 743720000016 recombination protein F; Reviewed; Region: recF; PRK00064 743720000017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720000018 Walker A/P-loop; other site 743720000019 ATP binding site [chemical binding]; other site 743720000020 Q-loop/lid; other site 743720000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720000022 ABC transporter signature motif; other site 743720000023 Walker B; other site 743720000024 D-loop; other site 743720000025 H-loop/switch region; other site 743720000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 743720000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720000028 Mg2+ binding site [ion binding]; other site 743720000029 G-X-G motif; other site 743720000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 743720000031 anchoring element; other site 743720000032 dimer interface [polypeptide binding]; other site 743720000033 ATP binding site [chemical binding]; other site 743720000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 743720000035 active site 743720000036 putative metal-binding site [ion binding]; other site 743720000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 743720000038 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 743720000039 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743720000040 putative acyl-acceptor binding pocket; other site 743720000041 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 743720000042 active site 743720000043 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 743720000044 active site 743720000045 catalytic residues [active] 743720000046 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 743720000047 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720000048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720000049 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 743720000050 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743720000051 putative acyl-acceptor binding pocket; other site 743720000052 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 743720000053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720000054 active site 743720000055 motif I; other site 743720000056 motif II; other site 743720000057 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 743720000058 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 743720000059 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 743720000060 dimer interface [polypeptide binding]; other site 743720000061 motif 1; other site 743720000062 active site 743720000063 motif 2; other site 743720000064 motif 3; other site 743720000065 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 743720000066 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 743720000067 Protein of unknown function (DUF3649); Region: DUF3649; pfam12365 743720000068 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 743720000069 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 743720000070 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 743720000071 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 743720000072 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 743720000073 putative acyl-acceptor binding pocket; other site 743720000074 PilZ domain; Region: PilZ; cl01260 743720000075 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 743720000076 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 743720000077 Walker A/P-loop; other site 743720000078 ATP binding site [chemical binding]; other site 743720000079 Q-loop/lid; other site 743720000080 ABC transporter signature motif; other site 743720000081 Walker B; other site 743720000082 D-loop; other site 743720000083 H-loop/switch region; other site 743720000084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000085 dimer interface [polypeptide binding]; other site 743720000086 conserved gate region; other site 743720000087 putative PBP binding loops; other site 743720000088 ABC-ATPase subunit interface; other site 743720000089 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720000090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000091 dimer interface [polypeptide binding]; other site 743720000092 conserved gate region; other site 743720000093 putative PBP binding loops; other site 743720000094 ABC-ATPase subunit interface; other site 743720000095 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 743720000096 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720000097 substrate binding pocket [chemical binding]; other site 743720000098 membrane-bound complex binding site; other site 743720000099 hinge residues; other site 743720000100 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720000101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720000102 DNA-binding site [nucleotide binding]; DNA binding site 743720000103 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720000104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720000105 homodimer interface [polypeptide binding]; other site 743720000106 catalytic residue [active] 743720000107 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 743720000108 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 743720000109 tetramer interface [polypeptide binding]; other site 743720000110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720000111 catalytic residue [active] 743720000112 ectoine utilization protein EutC; Validated; Region: PRK08291 743720000113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720000114 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 743720000115 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 743720000116 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 743720000117 active site 743720000118 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 743720000119 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 743720000120 putative active site [active] 743720000121 Zn binding site [ion binding]; other site 743720000122 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743720000123 Helix-turn-helix domains; Region: HTH; cl00088 743720000124 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 743720000125 NMT1-like family; Region: NMT1_2; cl15260 743720000126 Protein of unknown function (DUF1175); Region: DUF1175; cl14898 743720000127 NlpC/P60 family; Region: NLPC_P60; cl11438 743720000128 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 743720000129 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720000130 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 743720000131 tetramerization interface [polypeptide binding]; other site 743720000132 NAD(P) binding site [chemical binding]; other site 743720000133 catalytic residues [active] 743720000134 hypothetical protein; Provisional; Region: PRK07482 743720000135 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720000136 inhibitor-cofactor binding pocket; inhibition site 743720000137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720000138 catalytic residue [active] 743720000139 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 743720000140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720000141 putative substrate translocation pore; other site 743720000142 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 743720000143 Helix-turn-helix domains; Region: HTH; cl00088 743720000144 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 743720000145 dimerization interface [polypeptide binding]; other site 743720000146 substrate binding pocket [chemical binding]; other site 743720000147 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720000148 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720000149 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720000150 dimer interface [polypeptide binding]; other site 743720000151 putative CheW interface [polypeptide binding]; other site 743720000152 TPR repeat; Region: TPR_11; pfam13414 743720000153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 743720000154 binding surface 743720000155 TPR motif; other site 743720000156 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 743720000157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720000158 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 743720000159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720000160 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 743720000161 16S rRNA methyltransferase B; Provisional; Region: PRK10901 743720000162 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 743720000163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720000164 S-adenosylmethionine binding site [chemical binding]; other site 743720000165 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 743720000166 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 743720000167 putative active site [active] 743720000168 substrate binding site [chemical binding]; other site 743720000169 putative cosubstrate binding site; other site 743720000170 catalytic site [active] 743720000171 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 743720000172 substrate binding site [chemical binding]; other site 743720000173 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 743720000174 active site 743720000175 catalytic residues [active] 743720000176 metal binding site [ion binding]; metal-binding site 743720000177 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 743720000178 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 743720000179 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 743720000180 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 743720000181 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 743720000182 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 743720000183 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 743720000184 NADP binding site [chemical binding]; other site 743720000185 dimer interface [polypeptide binding]; other site 743720000186 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 743720000187 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 743720000188 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 743720000189 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 743720000190 shikimate binding site; other site 743720000191 NAD(P) binding site [chemical binding]; other site 743720000192 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 743720000193 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 743720000194 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 743720000195 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 743720000196 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 743720000197 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 743720000198 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 743720000199 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 743720000200 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 743720000201 Precorrin-8X methylmutase; Region: CbiC; pfam02570 743720000202 precorrin-3B synthase; Region: CobG; TIGR02435 743720000203 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720000204 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720000205 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 743720000206 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 743720000207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720000208 S-adenosylmethionine binding site [chemical binding]; other site 743720000209 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 743720000210 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 743720000211 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 743720000212 dimer interface [polypeptide binding]; other site 743720000213 [2Fe-2S] cluster binding site [ion binding]; other site 743720000214 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 743720000215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720000216 dimer interface [polypeptide binding]; other site 743720000217 phosphorylation site [posttranslational modification] 743720000218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720000219 ATP binding site [chemical binding]; other site 743720000220 Mg2+ binding site [ion binding]; other site 743720000221 G-X-G motif; other site 743720000222 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720000223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000224 active site 743720000225 phosphorylation site [posttranslational modification] 743720000226 intermolecular recognition site; other site 743720000227 dimerization interface [polypeptide binding]; other site 743720000228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000229 Walker A motif; other site 743720000230 ATP binding site [chemical binding]; other site 743720000231 Walker B motif; other site 743720000232 arginine finger; other site 743720000233 Helix-turn-helix domains; Region: HTH; cl00088 743720000234 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 743720000235 NMT1-like family; Region: NMT1_2; cl15260 743720000236 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 743720000237 DctM-like transporters; Region: DctM; pfam06808 743720000238 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 743720000239 Ion transport protein; Region: Ion_trans; pfam00520 743720000240 Polycystin cation channel; Region: PKD_channel; pfam08016 743720000241 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720000242 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 743720000243 transcriptional repressor UlaR; Provisional; Region: PRK13509 743720000244 Helix-turn-helix domains; Region: HTH; cl00088 743720000245 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 743720000246 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720000247 classical (c) SDRs; Region: SDR_c; cd05233 743720000248 NAD(P) binding site [chemical binding]; other site 743720000249 active site 743720000250 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 743720000251 BNR repeat-like domain; Region: BNR_2; pfam13088 743720000252 Sodium:solute symporter family; Region: SSF; cl00456 743720000253 putative transporter; Provisional; Region: PRK10484 743720000254 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 743720000255 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 743720000256 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 743720000257 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 743720000258 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 743720000259 putative active site [active] 743720000260 metal binding site [ion binding]; metal-binding site 743720000261 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 743720000262 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 743720000263 inhibitor site; inhibition site 743720000264 active site 743720000265 dimer interface [polypeptide binding]; other site 743720000266 catalytic residue [active] 743720000267 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 743720000268 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 743720000269 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 743720000270 putative active site [active] 743720000271 catalytic site [active] 743720000272 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 743720000273 putative active site [active] 743720000274 catalytic site [active] 743720000275 Sodium:solute symporter family; Region: SSF; cl00456 743720000276 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 743720000277 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 743720000278 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 743720000279 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720000280 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 743720000281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720000282 Walker A/P-loop; other site 743720000283 ATP binding site [chemical binding]; other site 743720000284 Q-loop/lid; other site 743720000285 ABC transporter signature motif; other site 743720000286 Walker B; other site 743720000287 D-loop; other site 743720000288 H-loop/switch region; other site 743720000289 TOBE domain; Region: TOBE_2; cl01440 743720000290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000291 dimer interface [polypeptide binding]; other site 743720000292 conserved gate region; other site 743720000293 putative PBP binding loops; other site 743720000294 ABC-ATPase subunit interface; other site 743720000295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000296 dimer interface [polypeptide binding]; other site 743720000297 conserved gate region; other site 743720000298 putative PBP binding loops; other site 743720000299 ABC-ATPase subunit interface; other site 743720000300 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 743720000301 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720000302 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485 743720000303 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 743720000304 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 743720000305 dimerization interface [polypeptide binding]; other site 743720000306 active site 743720000307 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 743720000308 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 743720000309 substrate binding site [chemical binding]; other site 743720000310 ATP binding site [chemical binding]; other site 743720000311 Sodium:solute symporter family; Region: SSF; cl00456 743720000312 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 743720000313 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 743720000314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720000315 DNA-binding site [nucleotide binding]; DNA binding site 743720000316 UTRA domain; Region: UTRA; cl01230 743720000317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720000318 Helix-turn-helix domains; Region: HTH; cl00088 743720000319 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 743720000320 putative dimerization interface [polypeptide binding]; other site 743720000321 EamA-like transporter family; Region: EamA; cl01037 743720000322 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 743720000323 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 743720000324 nudix motif; other site 743720000325 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720000326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720000327 DNA-binding site [nucleotide binding]; DNA binding site 743720000328 FCD domain; Region: FCD; cl11656 743720000329 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 743720000330 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720000331 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 743720000332 tetramerization interface [polypeptide binding]; other site 743720000333 NAD(P) binding site [chemical binding]; other site 743720000334 catalytic residues [active] 743720000335 Flavin Reductases; Region: FlaRed; cl00801 743720000336 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720000337 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 743720000338 NAD(P) binding site [chemical binding]; other site 743720000339 catalytic residues [active] 743720000340 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 743720000341 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720000342 Amino acid synthesis; Region: AA_synth; pfam06684 743720000343 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 743720000344 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 743720000345 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 743720000346 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720000347 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720000348 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 743720000349 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 743720000350 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 743720000351 active site 743720000352 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 743720000353 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 743720000354 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 743720000355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720000356 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 743720000357 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 743720000358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720000359 putative substrate translocation pore; other site 743720000360 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720000361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000362 active site 743720000363 phosphorylation site [posttranslational modification] 743720000364 intermolecular recognition site; other site 743720000365 dimerization interface [polypeptide binding]; other site 743720000366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000367 Walker A motif; other site 743720000368 ATP binding site [chemical binding]; other site 743720000369 Walker B motif; other site 743720000370 arginine finger; other site 743720000371 Helix-turn-helix domains; Region: HTH; cl00088 743720000372 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 743720000373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720000374 dimer interface [polypeptide binding]; other site 743720000375 phosphorylation site [posttranslational modification] 743720000376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720000377 ATP binding site [chemical binding]; other site 743720000378 Mg2+ binding site [ion binding]; other site 743720000379 G-X-G motif; other site 743720000380 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 743720000381 putative cation:proton antiport protein; Provisional; Region: PRK10669 743720000382 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 743720000383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720000384 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 743720000385 Tetratricopeptide repeat; Region: TPR_12; pfam13424 743720000386 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 743720000387 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 743720000388 Tim44-like domain; Region: Tim44; cl09208 743720000389 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720000390 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 743720000391 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 743720000392 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720000393 Family description; Region: UvrD_C_2; cl15862 743720000394 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 743720000395 Surface antigen; Region: Bac_surface_Ag; cl03097 743720000396 haemagglutination activity domain; Region: Haemagg_act; cl05436 743720000397 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 743720000398 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 743720000399 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 743720000400 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 743720000401 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 743720000402 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 743720000403 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 743720000404 Transposase IS200 like; Region: Y1_Tnp; cl00848 743720000405 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 743720000406 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 743720000407 active site 743720000408 catalytic residues [active] 743720000409 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720000410 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 743720000411 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 743720000412 muropeptide transporter; Validated; Region: ampG; PRK11010 743720000413 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 743720000414 Sulfate transporter family; Region: Sulfate_transp; cl15842 743720000415 Sulfate transporter family; Region: Sulfate_transp; cl15842 743720000416 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 743720000417 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 743720000418 NMT1-like family; Region: NMT1_2; cl15260 743720000419 Sulfatase; Region: Sulfatase; cl10460 743720000420 choline-sulfatase; Region: chol_sulfatase; TIGR03417 743720000421 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 743720000422 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 743720000423 Helix-turn-helix domains; Region: HTH; cl00088 743720000424 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 743720000425 dimerization interface [polypeptide binding]; other site 743720000426 substrate binding pocket [chemical binding]; other site 743720000427 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562 743720000428 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 743720000429 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 743720000430 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720000431 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720000432 Helix-turn-helix domains; Region: HTH; cl00088 743720000433 LysR family transcriptional regulator; Provisional; Region: PRK14997 743720000434 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720000435 putative effector binding pocket; other site 743720000436 dimerization interface [polypeptide binding]; other site 743720000437 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 743720000438 NADH(P)-binding; Region: NAD_binding_10; pfam13460 743720000439 NAD binding site [chemical binding]; other site 743720000440 putative active site [active] 743720000441 substrate binding site [chemical binding]; other site 743720000442 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 743720000443 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 743720000444 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 743720000445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720000446 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 743720000447 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 743720000448 substrate binding site [chemical binding]; other site 743720000449 active site 743720000450 catalytic residues [active] 743720000451 heterodimer interface [polypeptide binding]; other site 743720000452 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 743720000453 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 743720000454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720000455 catalytic residue [active] 743720000456 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 743720000457 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 743720000458 Helix-turn-helix domains; Region: HTH; cl00088 743720000459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720000460 dimerization interface [polypeptide binding]; other site 743720000461 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 743720000462 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 743720000463 dimer interface [polypeptide binding]; other site 743720000464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720000465 active site 743720000466 metal binding site [ion binding]; metal-binding site 743720000467 glutathione binding site [chemical binding]; other site 743720000468 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 743720000469 active site 743720000470 metal binding site [ion binding]; metal-binding site 743720000471 homotetramer interface [polypeptide binding]; other site 743720000472 Dehydratase family; Region: ILVD_EDD; cl00340 743720000473 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 743720000474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000475 active site 743720000476 phosphorylation site [posttranslational modification] 743720000477 intermolecular recognition site; other site 743720000478 dimerization interface [polypeptide binding]; other site 743720000479 CheB methylesterase; Region: CheB_methylest; pfam01339 743720000480 CheD chemotactic sensory transduction; Region: CheD; cl00810 743720000481 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 743720000482 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 743720000483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720000484 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 743720000485 putative CheA interaction surface; other site 743720000486 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720000487 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720000488 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720000489 dimer interface [polypeptide binding]; other site 743720000490 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 743720000491 putative CheW interface [polypeptide binding]; other site 743720000492 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 743720000493 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 743720000494 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720000495 putative binding surface; other site 743720000496 active site 743720000497 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 743720000498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720000499 ATP binding site [chemical binding]; other site 743720000500 Mg2+ binding site [ion binding]; other site 743720000501 G-X-G motif; other site 743720000502 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 743720000503 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 743720000504 anti sigma factor interaction site; other site 743720000505 regulatory phosphorylation site [posttranslational modification]; other site 743720000506 Response regulator receiver domain; Region: Response_reg; pfam00072 743720000507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000508 active site 743720000509 phosphorylation site [posttranslational modification] 743720000510 intermolecular recognition site; other site 743720000511 dimerization interface [polypeptide binding]; other site 743720000512 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720000513 dimer interface [polypeptide binding]; other site 743720000514 putative CheW interface [polypeptide binding]; other site 743720000515 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720000516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000517 active site 743720000518 phosphorylation site [posttranslational modification] 743720000519 intermolecular recognition site; other site 743720000520 dimerization interface [polypeptide binding]; other site 743720000521 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720000522 DNA binding residues [nucleotide binding] 743720000523 dimerization interface [polypeptide binding]; other site 743720000524 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 743720000525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720000526 S-adenosylmethionine binding site [chemical binding]; other site 743720000527 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 743720000528 intracellular protease, PfpI family; Region: PfpI; TIGR01382 743720000529 proposed catalytic triad [active] 743720000530 conserved cys residue [active] 743720000531 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 743720000532 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 743720000533 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 743720000534 DNA binding site [nucleotide binding] 743720000535 catalytic residue [active] 743720000536 H2TH interface [polypeptide binding]; other site 743720000537 putative catalytic residues [active] 743720000538 turnover-facilitating residue; other site 743720000539 intercalation triad [nucleotide binding]; other site 743720000540 8OG recognition residue [nucleotide binding]; other site 743720000541 putative reading head residues; other site 743720000542 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 743720000543 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 743720000544 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 743720000545 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 743720000546 ferredoxin; Validated; Region: PRK07118 743720000547 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 743720000548 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 743720000549 active site 743720000550 (T/H)XGH motif; other site 743720000551 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 743720000552 NAD(P) binding site [chemical binding]; other site 743720000553 catalytic residues [active] 743720000554 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 743720000555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720000556 S-adenosylmethionine binding site [chemical binding]; other site 743720000557 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 743720000558 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 743720000559 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 743720000560 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 743720000561 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 743720000562 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 743720000563 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 743720000564 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 743720000565 P loop; other site 743720000566 GTP binding site [chemical binding]; other site 743720000567 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 743720000568 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720000569 Walker A/P-loop; other site 743720000570 ATP binding site [chemical binding]; other site 743720000571 Q-loop/lid; other site 743720000572 ABC transporter signature motif; other site 743720000573 Walker B; other site 743720000574 D-loop; other site 743720000575 H-loop/switch region; other site 743720000576 FtsX-like permease family; Region: FtsX; cl15850 743720000577 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 743720000578 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 743720000579 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 743720000580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720000581 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720000582 DNA binding residues [nucleotide binding] 743720000583 Transglycosylase; Region: Transgly; cl07896 743720000584 Protein of unknown function (DUF423); Region: DUF423; cl01008 743720000585 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 743720000586 thiS-thiF/thiG interaction site; other site 743720000587 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 743720000588 ThiS interaction site; other site 743720000589 putative active site [active] 743720000590 tetramer interface [polypeptide binding]; other site 743720000591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720000592 S-adenosylmethionine binding site [chemical binding]; other site 743720000593 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 743720000594 EamA-like transporter family; Region: EamA; cl01037 743720000595 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 743720000596 putative active site [active] 743720000597 putative DNA binding site [nucleotide binding]; other site 743720000598 putative phosphate binding site [ion binding]; other site 743720000599 putative catalytic site [active] 743720000600 metal binding site A [ion binding]; metal-binding site 743720000601 putative AP binding site [nucleotide binding]; other site 743720000602 putative metal binding site B [ion binding]; other site 743720000603 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 743720000604 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720000605 active site 743720000606 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 743720000607 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 743720000608 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720000609 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 743720000610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000611 ABC-ATPase subunit interface; other site 743720000612 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 743720000613 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 743720000614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000615 dimer interface [polypeptide binding]; other site 743720000616 conserved gate region; other site 743720000617 putative PBP binding loops; other site 743720000618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743720000619 ABC-ATPase subunit interface; other site 743720000620 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 743720000621 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 743720000622 Walker A/P-loop; other site 743720000623 ATP binding site [chemical binding]; other site 743720000624 Q-loop/lid; other site 743720000625 ABC transporter signature motif; other site 743720000626 Walker B; other site 743720000627 D-loop; other site 743720000628 H-loop/switch region; other site 743720000629 transcriptional regulator PhoU; Provisional; Region: PRK11115 743720000630 PhoU domain; Region: PhoU; pfam01895 743720000631 PhoU domain; Region: PhoU; pfam01895 743720000632 Response regulator receiver domain; Region: Response_reg; pfam00072 743720000633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000634 active site 743720000635 phosphorylation site [posttranslational modification] 743720000636 intermolecular recognition site; other site 743720000637 dimerization interface [polypeptide binding]; other site 743720000638 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 743720000639 DNA photolyase; Region: DNA_photolyase; pfam00875 743720000640 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 743720000641 MarC family integral membrane protein; Region: MarC; cl00919 743720000642 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 743720000643 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 743720000644 amidase catalytic site [active] 743720000645 Zn binding residues [ion binding]; other site 743720000646 substrate binding site [chemical binding]; other site 743720000647 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 743720000648 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720000649 dimerization interface [polypeptide binding]; other site 743720000650 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 743720000651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720000652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720000653 dimer interface [polypeptide binding]; other site 743720000654 phosphorylation site [posttranslational modification] 743720000655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720000656 ATP binding site [chemical binding]; other site 743720000657 Mg2+ binding site [ion binding]; other site 743720000658 G-X-G motif; other site 743720000659 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720000660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000661 active site 743720000662 phosphorylation site [posttranslational modification] 743720000663 intermolecular recognition site; other site 743720000664 dimerization interface [polypeptide binding]; other site 743720000665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000666 Walker A motif; other site 743720000667 ATP binding site [chemical binding]; other site 743720000668 Walker B motif; other site 743720000669 arginine finger; other site 743720000670 Helix-turn-helix domains; Region: HTH; cl00088 743720000671 BON domain; Region: BON; cl02771 743720000672 BON domain; Region: BON; cl02771 743720000673 BON domain; Region: BON; cl02771 743720000674 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 743720000675 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428 743720000676 Nucleoside recognition; Region: Gate; cl00486 743720000677 Nucleoside recognition; Region: Gate; cl00486 743720000678 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 743720000679 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720000680 Helix-turn-helix domains; Region: HTH; cl00088 743720000681 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 743720000682 dimerization interface [polypeptide binding]; other site 743720000683 substrate binding pocket [chemical binding]; other site 743720000684 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 743720000685 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 743720000686 FAD binding site [chemical binding]; other site 743720000687 substrate binding pocket [chemical binding]; other site 743720000688 catalytic base [active] 743720000689 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 743720000690 CoA-transferase family III; Region: CoA_transf_3; pfam02515 743720000691 NnrS protein; Region: NnrS; cl01258 743720000692 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 743720000693 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 743720000694 heme-binding site [chemical binding]; other site 743720000695 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 743720000696 FAD binding pocket [chemical binding]; other site 743720000697 FAD binding motif [chemical binding]; other site 743720000698 phosphate binding motif [ion binding]; other site 743720000699 beta-alpha-beta structure motif; other site 743720000700 NAD binding pocket [chemical binding]; other site 743720000701 Heme binding pocket [chemical binding]; other site 743720000702 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 743720000703 GAF domain; Region: GAF; cl15785 743720000704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000705 Walker A motif; other site 743720000706 ATP binding site [chemical binding]; other site 743720000707 Walker B motif; other site 743720000708 arginine finger; other site 743720000709 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 743720000710 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 743720000711 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720000712 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 743720000713 tetramerization interface [polypeptide binding]; other site 743720000714 NAD(P) binding site [chemical binding]; other site 743720000715 catalytic residues [active] 743720000716 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 743720000717 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720000718 inhibitor-cofactor binding pocket; inhibition site 743720000719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720000720 catalytic residue [active] 743720000721 Response regulator receiver domain; Region: Response_reg; pfam00072 743720000722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000723 active site 743720000724 phosphorylation site [posttranslational modification] 743720000725 intermolecular recognition site; other site 743720000726 dimerization interface [polypeptide binding]; other site 743720000727 HDOD domain; Region: HDOD; pfam08668 743720000728 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 743720000729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720000730 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720000731 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720000732 dimer interface [polypeptide binding]; other site 743720000733 putative CheW interface [polypeptide binding]; other site 743720000734 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743720000735 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720000736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720000737 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 743720000738 xanthine permease; Region: pbuX; TIGR03173 743720000739 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 743720000740 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 743720000741 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720000742 substrate binding pocket [chemical binding]; other site 743720000743 membrane-bound complex binding site; other site 743720000744 hinge residues; other site 743720000745 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 743720000746 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 743720000747 Walker A/P-loop; other site 743720000748 ATP binding site [chemical binding]; other site 743720000749 Q-loop/lid; other site 743720000750 ABC transporter signature motif; other site 743720000751 Walker B; other site 743720000752 D-loop; other site 743720000753 H-loop/switch region; other site 743720000754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000755 dimer interface [polypeptide binding]; other site 743720000756 conserved gate region; other site 743720000757 putative PBP binding loops; other site 743720000758 ABC-ATPase subunit interface; other site 743720000759 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 743720000760 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 743720000761 Cache domain; Region: Cache_1; pfam02743 743720000762 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720000763 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 743720000764 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720000765 Dodecin; Region: Dodecin; cl01328 743720000766 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 743720000767 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 743720000768 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 743720000769 OsmC-like protein; Region: OsmC; cl00767 743720000770 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 743720000771 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 743720000772 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 743720000773 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 743720000774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720000775 motif II; other site 743720000776 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 743720000777 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 743720000778 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 743720000779 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 743720000780 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 743720000781 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 743720000782 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 743720000783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000784 Walker A motif; other site 743720000785 ATP binding site [chemical binding]; other site 743720000786 Walker B motif; other site 743720000787 arginine finger; other site 743720000788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000789 Walker A motif; other site 743720000790 ATP binding site [chemical binding]; other site 743720000791 Walker B motif; other site 743720000792 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 743720000793 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 743720000794 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 743720000795 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 743720000796 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 743720000797 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 743720000798 ImpE protein; Region: ImpE; pfam07024 743720000799 Protein of unknown function (DUF796); Region: DUF796; cl01226 743720000800 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 743720000801 Protein of unknown function (DUF877); Region: DUF877; pfam05943 743720000802 Protein of unknown function (DUF770); Region: DUF770; cl01402 743720000803 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 743720000804 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 743720000805 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 743720000806 phosphopeptide binding site; other site 743720000807 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 743720000808 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 743720000809 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 743720000810 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 743720000811 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 743720000812 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743720000813 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720000814 ligand binding site [chemical binding]; other site 743720000815 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 743720000816 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 743720000817 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 743720000818 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 743720000819 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 743720000820 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 743720000821 Protein phosphatase 2C; Region: PP2C; pfam00481 743720000822 active site 743720000823 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 743720000824 Catalytic domain of Protein Kinases; Region: PKc; cd00180 743720000825 active site 743720000826 ATP binding site [chemical binding]; other site 743720000827 substrate binding site [chemical binding]; other site 743720000828 activation loop (A-loop); other site 743720000829 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 743720000830 metal ion-dependent adhesion site (MIDAS); other site 743720000831 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 743720000832 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 743720000833 Walker A/P-loop; other site 743720000834 ATP binding site [chemical binding]; other site 743720000835 Q-loop/lid; other site 743720000836 ABC transporter signature motif; other site 743720000837 Walker B; other site 743720000838 D-loop; other site 743720000839 H-loop/switch region; other site 743720000840 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 743720000841 Cytochrome c; Region: Cytochrom_C; cl11414 743720000842 Cytochrome c; Region: Cytochrom_C; cl11414 743720000843 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 743720000844 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 743720000845 catalytic residues [active] 743720000846 hinge region; other site 743720000847 alpha helical domain; other site 743720000848 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 743720000849 putative catalytic site [active] 743720000850 putative metal binding site [ion binding]; other site 743720000851 putative phosphate binding site [ion binding]; other site 743720000852 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 743720000853 putative catalytic site [active] 743720000854 putative phosphate binding site [ion binding]; other site 743720000855 putative metal binding site [ion binding]; other site 743720000856 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720000857 metal binding site [ion binding]; metal-binding site 743720000858 active site 743720000859 I-site; other site 743720000860 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720000861 Peptidase family M23; Region: Peptidase_M23; pfam01551 743720000862 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 743720000863 putative metal binding site [ion binding]; other site 743720000864 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 743720000865 Domain of unknown function DUF21; Region: DUF21; pfam01595 743720000866 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 743720000867 Transporter associated domain; Region: CorC_HlyC; cl08393 743720000868 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 743720000869 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 743720000870 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720000871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720000872 dimer interface [polypeptide binding]; other site 743720000873 phosphorylation site [posttranslational modification] 743720000874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720000875 ATP binding site [chemical binding]; other site 743720000876 Mg2+ binding site [ion binding]; other site 743720000877 G-X-G motif; other site 743720000878 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 743720000879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000880 active site 743720000881 phosphorylation site [posttranslational modification] 743720000882 intermolecular recognition site; other site 743720000883 dimerization interface [polypeptide binding]; other site 743720000884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720000885 DNA binding site [nucleotide binding] 743720000886 UbiA prenyltransferase family; Region: UbiA; cl00337 743720000887 UTRA domain; Region: UTRA; cl01230 743720000888 Rubredoxin [Energy production and conversion]; Region: COG1773 743720000889 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 743720000890 iron binding site [ion binding]; other site 743720000891 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 743720000892 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720000893 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743720000894 IHF dimer interface [polypeptide binding]; other site 743720000895 IHF - DNA interface [nucleotide binding]; other site 743720000896 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 743720000897 putative deacylase active site [active] 743720000898 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 743720000899 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 743720000900 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 743720000901 generic binding surface II; other site 743720000902 ssDNA binding site; other site 743720000903 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720000904 ATP binding site [chemical binding]; other site 743720000905 putative Mg++ binding site [ion binding]; other site 743720000906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720000907 nucleotide binding region [chemical binding]; other site 743720000908 ATP-binding site [chemical binding]; other site 743720000909 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 743720000910 Helix-turn-helix domains; Region: HTH; cl00088 743720000911 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 743720000912 dimerization interface [polypeptide binding]; other site 743720000913 Gram-negative bacterial tonB protein; Region: TonB; cl10048 743720000914 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 743720000915 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 743720000916 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743720000917 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 743720000918 putative NAD(P) binding site [chemical binding]; other site 743720000919 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 743720000920 homotrimer interaction site [polypeptide binding]; other site 743720000921 putative active site [active] 743720000922 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 743720000923 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 743720000924 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 743720000925 synthetase active site [active] 743720000926 NTP binding site [chemical binding]; other site 743720000927 metal binding site [ion binding]; metal-binding site 743720000928 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 743720000929 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 743720000930 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 743720000931 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 743720000932 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 743720000933 catalytic site [active] 743720000934 G-X2-G-X-G-K; other site 743720000935 hypothetical protein; Provisional; Region: PRK11820 743720000936 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 743720000937 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 743720000938 ribonuclease PH; Reviewed; Region: rph; PRK00173 743720000939 Ribonuclease PH; Region: RNase_PH_bact; cd11362 743720000940 hexamer interface [polypeptide binding]; other site 743720000941 active site 743720000942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296; cl15800 743720000943 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 743720000944 HemN family oxidoreductase; Provisional; Region: PRK05660 743720000945 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720000946 FeS/SAM binding site; other site 743720000947 HemN C-terminal domain; Region: HemN_C; pfam06969 743720000948 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 743720000949 active site 743720000950 dimerization interface [polypeptide binding]; other site 743720000951 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 743720000952 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 743720000953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720000954 S-adenosylmethionine binding site [chemical binding]; other site 743720000955 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 743720000956 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720000957 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720000958 G1 box; other site 743720000959 GTP/Mg2+ binding site [chemical binding]; other site 743720000960 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 743720000961 G2 box; other site 743720000962 Switch I region; other site 743720000963 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720000964 G3 box; other site 743720000965 Switch II region; other site 743720000966 GTP/Mg2+ binding site [chemical binding]; other site 743720000967 G4 box; other site 743720000968 G5 box; other site 743720000969 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 743720000970 YGGT family; Region: YGGT; cl00508 743720000971 YGGT family; Region: YGGT; cl00508 743720000972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720000973 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 743720000974 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 743720000975 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720000976 catalytic residue [active] 743720000977 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 743720000978 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 743720000979 Walker A motif; other site 743720000980 ATP binding site [chemical binding]; other site 743720000981 Walker B motif; other site 743720000982 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 743720000983 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 743720000984 Walker A motif; other site 743720000985 ATP binding site [chemical binding]; other site 743720000986 Walker B motif; other site 743720000987 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 743720000988 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 743720000989 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720000990 FeS/SAM binding site; other site 743720000991 TM2 domain; Region: TM2; cl00984 743720000992 dihydroorotase; Validated; Region: pyrC; PRK09357 743720000993 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743720000994 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 743720000995 active site 743720000996 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 743720000997 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 743720000998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720000999 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720001000 active site 743720001001 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 743720001002 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 743720001003 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 743720001004 Gram-negative bacterial tonB protein; Region: TonB; cl10048 743720001005 glutathione synthetase; Provisional; Region: PRK05246 743720001006 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 743720001007 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720001008 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001010 active site 743720001011 phosphorylation site [posttranslational modification] 743720001012 intermolecular recognition site; other site 743720001013 dimerization interface [polypeptide binding]; other site 743720001014 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001016 active site 743720001017 phosphorylation site [posttranslational modification] 743720001018 intermolecular recognition site; other site 743720001019 dimerization interface [polypeptide binding]; other site 743720001020 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 743720001021 putative CheA interaction surface; other site 743720001022 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 743720001023 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720001024 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720001025 dimer interface [polypeptide binding]; other site 743720001026 putative CheW interface [polypeptide binding]; other site 743720001027 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 743720001028 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 743720001029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001030 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720001031 putative binding surface; other site 743720001032 active site 743720001033 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 743720001034 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720001035 putative binding surface; other site 743720001036 active site 743720001037 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720001038 putative binding surface; other site 743720001039 active site 743720001040 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 743720001041 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 743720001042 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 743720001043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001044 ATP binding site [chemical binding]; other site 743720001045 Mg2+ binding site [ion binding]; other site 743720001046 G-X-G motif; other site 743720001047 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 743720001048 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001050 active site 743720001051 phosphorylation site [posttranslational modification] 743720001052 intermolecular recognition site; other site 743720001053 dimerization interface [polypeptide binding]; other site 743720001054 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 743720001055 CheB methylesterase; Region: CheB_methylest; pfam01339 743720001056 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 743720001057 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 743720001058 Ferritin-like domain; Region: Ferritin; pfam00210 743720001059 dinuclear metal binding motif [ion binding]; other site 743720001060 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 743720001061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 743720001062 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 743720001063 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 743720001064 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720001065 inhibitor-cofactor binding pocket; inhibition site 743720001066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720001067 catalytic residue [active] 743720001068 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 743720001069 YceI-like domain; Region: YceI; cl01001 743720001070 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 743720001071 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743720001072 ATP binding site [chemical binding]; other site 743720001073 Mg++ binding site [ion binding]; other site 743720001074 motif III; other site 743720001075 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720001076 nucleotide binding region [chemical binding]; other site 743720001077 ATP-binding site [chemical binding]; other site 743720001078 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 743720001079 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 743720001080 FAD binding pocket [chemical binding]; other site 743720001081 FAD binding motif [chemical binding]; other site 743720001082 phosphate binding motif [ion binding]; other site 743720001083 NAD binding pocket [chemical binding]; other site 743720001084 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 743720001085 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 743720001086 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 743720001087 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 743720001088 FAD binding site [chemical binding]; other site 743720001089 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 743720001090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001091 oligomerization interface [polypeptide binding]; other site 743720001092 active site 743720001093 NAD+ binding site [chemical binding]; other site 743720001094 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 743720001095 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 743720001096 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 743720001097 nucleotide binding pocket [chemical binding]; other site 743720001098 K-X-D-G motif; other site 743720001099 catalytic site [active] 743720001100 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 743720001101 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 743720001102 S-adenosylmethionine synthetase; Validated; Region: PRK05250 743720001103 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 743720001104 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 743720001105 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 743720001106 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720001107 putative DNA binding site [nucleotide binding]; other site 743720001108 dimerization interface [polypeptide binding]; other site 743720001109 putative Zn2+ binding site [ion binding]; other site 743720001110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720001111 S-adenosylmethionine binding site [chemical binding]; other site 743720001112 transketolase; Reviewed; Region: PRK12753 743720001113 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 743720001114 TPP-binding site [chemical binding]; other site 743720001115 dimer interface [polypeptide binding]; other site 743720001116 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 743720001117 PYR/PP interface [polypeptide binding]; other site 743720001118 dimer interface [polypeptide binding]; other site 743720001119 TPP binding site [chemical binding]; other site 743720001120 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743720001121 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 743720001122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001123 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 743720001124 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 743720001125 Phosphoglycerate kinase; Region: PGK; pfam00162 743720001126 substrate binding site [chemical binding]; other site 743720001127 hinge regions; other site 743720001128 ADP binding site [chemical binding]; other site 743720001129 catalytic site [active] 743720001130 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 743720001131 hypothetical protein; Provisional; Region: PRK08185 743720001132 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 743720001133 intersubunit interface [polypeptide binding]; other site 743720001134 active site 743720001135 zinc binding site [ion binding]; other site 743720001136 Na+ binding site [ion binding]; other site 743720001137 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 743720001138 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 743720001139 Protein of unknown function DUF45; Region: DUF45; cl00636 743720001140 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743720001141 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 743720001142 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 743720001143 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 743720001144 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 743720001145 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 743720001146 C-terminal domain interface [polypeptide binding]; other site 743720001147 GSH binding site (G-site) [chemical binding]; other site 743720001148 dimer interface [polypeptide binding]; other site 743720001149 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 743720001150 N-terminal domain interface [polypeptide binding]; other site 743720001151 putative dimer interface [polypeptide binding]; other site 743720001152 active site 743720001153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001154 PAS fold; Region: PAS_3; pfam08447 743720001155 putative active site [active] 743720001156 heme pocket [chemical binding]; other site 743720001157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001158 PAS domain; Region: PAS_9; pfam13426 743720001159 putative active site [active] 743720001160 heme pocket [chemical binding]; other site 743720001161 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720001162 metal binding site [ion binding]; metal-binding site 743720001163 active site 743720001164 I-site; other site 743720001165 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720001166 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 743720001167 Di-iron ligands [ion binding]; other site 743720001168 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 743720001169 Transposase; Region: DDE_Tnp_ISL3; pfam01610 743720001170 PAS domain S-box; Region: sensory_box; TIGR00229 743720001171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001172 putative active site [active] 743720001173 heme pocket [chemical binding]; other site 743720001174 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 743720001175 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720001176 metal binding site [ion binding]; metal-binding site 743720001177 active site 743720001178 I-site; other site 743720001179 outer membrane porin, OprD family; Region: OprD; pfam03573 743720001180 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 743720001181 agmatine deiminase; Region: agmatine_aguA; TIGR03380 743720001182 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720001183 Helix-turn-helix domains; Region: HTH; cl00088 743720001184 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743720001185 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720001186 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743720001187 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720001188 putative aminotransferase; Validated; Region: PRK07480 743720001189 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720001190 inhibitor-cofactor binding pocket; inhibition site 743720001191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720001192 catalytic residue [active] 743720001193 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 743720001194 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720001195 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 743720001196 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720001197 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 743720001198 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720001199 Walker A/P-loop; other site 743720001200 ATP binding site [chemical binding]; other site 743720001201 Q-loop/lid; other site 743720001202 ABC transporter signature motif; other site 743720001203 Walker B; other site 743720001204 D-loop; other site 743720001205 H-loop/switch region; other site 743720001206 TOBE domain; Region: TOBE_2; cl01440 743720001207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720001208 dimer interface [polypeptide binding]; other site 743720001209 conserved gate region; other site 743720001210 putative PBP binding loops; other site 743720001211 ABC-ATPase subunit interface; other site 743720001212 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 743720001213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720001214 dimer interface [polypeptide binding]; other site 743720001215 conserved gate region; other site 743720001216 putative PBP binding loops; other site 743720001217 ABC-ATPase subunit interface; other site 743720001218 BCCT family transporter; Region: BCCT; cl00569 743720001219 Membrane fusogenic activity; Region: BMFP; cl01115 743720001220 Nitrogen regulatory protein P-II; Region: P-II; cl00412 743720001221 Nitrogen regulatory protein P-II; Region: P-II; smart00938 743720001222 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 743720001223 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 743720001224 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 743720001225 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 743720001226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720001227 motif II; other site 743720001228 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 743720001229 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 743720001230 Int/Topo IB signature motif; other site 743720001231 active site 743720001232 GAF domain; Region: GAF; cl15785 743720001233 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 743720001234 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 743720001235 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 743720001236 diaminopimelate decarboxylase; Region: lysA; TIGR01048 743720001237 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 743720001238 active site 743720001239 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720001240 substrate binding site [chemical binding]; other site 743720001241 catalytic residues [active] 743720001242 dimer interface [polypeptide binding]; other site 743720001243 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 743720001244 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cl00238 743720001245 putative iron binding site [ion binding]; other site 743720001246 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 743720001247 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 743720001248 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743720001249 adenylate cyclase; Provisional; Region: cyaA; PRK09450 743720001250 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 743720001251 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 743720001252 adenylate cyclase; Provisional; Region: cyaA; PRK09450 743720001253 Phosphate-starvation-inducible E; Region: PsiE; cl01264 743720001254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720001255 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720001256 substrate binding pocket [chemical binding]; other site 743720001257 membrane-bound complex binding site; other site 743720001258 hinge residues; other site 743720001259 Transcriptional regulator [Transcription]; Region: IclR; COG1414 743720001260 Helix-turn-helix domains; Region: HTH; cl00088 743720001261 Bacterial transcriptional regulator; Region: IclR; pfam01614 743720001262 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 743720001263 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 743720001264 active site 743720001265 intersubunit interface [polypeptide binding]; other site 743720001266 catalytic residue [active] 743720001267 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 743720001268 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720001269 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 743720001270 C-terminal domain interface [polypeptide binding]; other site 743720001271 GSH binding site (G-site) [chemical binding]; other site 743720001272 dimer interface [polypeptide binding]; other site 743720001273 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 743720001274 N-terminal domain interface [polypeptide binding]; other site 743720001275 dimer interface [polypeptide binding]; other site 743720001276 substrate binding pocket (H-site) [chemical binding]; other site 743720001277 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 743720001278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720001279 Coenzyme A binding pocket [chemical binding]; other site 743720001280 argininosuccinate lyase; Provisional; Region: PRK00855 743720001281 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 743720001282 active sites [active] 743720001283 tetramer interface [polypeptide binding]; other site 743720001284 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 743720001285 Histidine kinase; Region: His_kinase; pfam06580 743720001286 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 743720001287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001288 active site 743720001289 phosphorylation site [posttranslational modification] 743720001290 intermolecular recognition site; other site 743720001291 dimerization interface [polypeptide binding]; other site 743720001292 LytTr DNA-binding domain; Region: LytTR; cl04498 743720001293 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 743720001294 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 743720001295 domain interfaces; other site 743720001296 active site 743720001297 uroporphyrinogen-III synthase; Validated; Region: PRK05752 743720001298 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 743720001299 active site 743720001300 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 743720001301 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 743720001302 HemY protein N-terminus; Region: HemY_N; pfam07219 743720001303 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; cl11478 743720001304 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 743720001305 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 743720001306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720001307 Helix-turn-helix domains; Region: HTH; cl00088 743720001308 Bacterial transcriptional repressor; Region: TetR; pfam13972 743720001309 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 743720001310 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720001311 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 743720001312 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 743720001313 Protein of unknown function (DUF971); Region: DUF971; cl01414 743720001314 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 743720001315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720001316 Walker A motif; other site 743720001317 ATP binding site [chemical binding]; other site 743720001318 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720001319 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 743720001320 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 743720001321 active site 743720001322 Sporulation related domain; Region: SPOR; cl10051 743720001323 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 743720001324 arginine-tRNA ligase; Region: PLN02286 743720001325 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 743720001326 active site 743720001327 HIGH motif; other site 743720001328 KMSK motif region; other site 743720001329 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 743720001330 tRNA binding surface [nucleotide binding]; other site 743720001331 anticodon binding site; other site 743720001332 primosome assembly protein PriA; Validated; Region: PRK05580 743720001333 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720001334 ATP binding site [chemical binding]; other site 743720001335 putative Mg++ binding site [ion binding]; other site 743720001336 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720001337 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 743720001338 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 743720001339 Catalytic site; other site 743720001340 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 743720001341 Peptidase family M48; Region: Peptidase_M48; cl12018 743720001342 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 743720001343 Malic enzyme, N-terminal domain; Region: malic; pfam00390 743720001344 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 743720001345 putative NAD(P) binding site [chemical binding]; other site 743720001346 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 743720001347 Transglycosylase; Region: Transgly; cl07896 743720001348 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720001349 Competence protein A; Region: Competence_A; pfam11104 743720001350 Cell division protein FtsA; Region: FtsA; cl11496 743720001351 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 743720001352 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 743720001353 Pilus assembly protein, PilO; Region: PilO; cl01234 743720001354 Pilus assembly protein, PilP; Region: PilP; cl01235 743720001355 AMIN domain; Region: AMIN; pfam11741 743720001356 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 743720001357 Secretin and TonB N terminus short domain; Region: STN; cl06624 743720001358 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 743720001359 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 743720001360 shikimate kinase; Reviewed; Region: aroK; PRK00131 743720001361 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 743720001362 ADP binding site [chemical binding]; other site 743720001363 magnesium binding site [ion binding]; other site 743720001364 putative shikimate binding site; other site 743720001365 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 743720001366 active site 743720001367 dimer interface [polypeptide binding]; other site 743720001368 metal binding site [ion binding]; metal-binding site 743720001369 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 743720001370 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720001371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 743720001372 Sporulation related domain; Region: SPOR; cl10051 743720001373 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 743720001374 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 743720001375 active site 743720001376 dimer interface [polypeptide binding]; other site 743720001377 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 743720001378 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 743720001379 active site 743720001380 FMN binding site [chemical binding]; other site 743720001381 substrate binding site [chemical binding]; other site 743720001382 3Fe-4S cluster binding site [ion binding]; other site 743720001383 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 743720001384 domain interface; other site 743720001385 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 743720001386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720001388 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 743720001389 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 743720001390 substrate binding site [chemical binding]; other site 743720001391 active site 743720001392 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 743720001393 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 743720001394 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 743720001395 dimer interface [polypeptide binding]; other site 743720001396 active site 743720001397 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 743720001398 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 743720001399 active site 743720001400 Phosphopantetheine attachment site; Region: PP-binding; cl09936 743720001401 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 743720001402 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 743720001403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720001404 Walker A/P-loop; other site 743720001405 ATP binding site [chemical binding]; other site 743720001406 Q-loop/lid; other site 743720001407 ABC transporter signature motif; other site 743720001408 Walker B; other site 743720001409 D-loop; other site 743720001410 H-loop/switch region; other site 743720001411 Phospholipid methyltransferase; Region: PEMT; cl00763 743720001412 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 743720001413 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 743720001414 dimer interface [polypeptide binding]; other site 743720001415 active site 743720001416 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720001417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001418 NAD(P) binding site [chemical binding]; other site 743720001419 active site 743720001420 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 743720001421 putative active site 1 [active] 743720001422 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 743720001423 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 743720001424 dimer interface [polypeptide binding]; other site 743720001425 active site 743720001426 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 743720001427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720001428 S-adenosylmethionine binding site [chemical binding]; other site 743720001429 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 743720001430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001431 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 743720001432 Predicted exporter [General function prediction only]; Region: COG4258 743720001433 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 743720001434 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743720001435 active site 743720001436 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 743720001437 active sites [active] 743720001438 tetramer interface [polypeptide binding]; other site 743720001439 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 743720001440 putative acyl-acceptor binding pocket; other site 743720001441 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 743720001442 Ligand binding site; other site 743720001443 Putative Catalytic site; other site 743720001444 DXD motif; other site 743720001445 AMP-binding enzyme; Region: AMP-binding; cl15778 743720001446 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 743720001447 active site 2 [active] 743720001448 dimer interface [polypeptide binding]; other site 743720001449 active site 1 [active] 743720001450 Predicted membrane protein [Function unknown]; Region: COG4648 743720001451 Phosphopantetheine attachment site; Region: PP-binding; cl09936 743720001452 Phosphopantetheine attachment site; Region: PP-binding; cl09936 743720001453 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743720001454 putative acyl-acceptor binding pocket; other site 743720001455 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 743720001456 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 743720001457 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743720001458 P-loop; other site 743720001459 Magnesium ion binding site [ion binding]; other site 743720001460 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743720001461 Magnesium ion binding site [ion binding]; other site 743720001462 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720001463 Ligand Binding Site [chemical binding]; other site 743720001464 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720001465 Ligand Binding Site [chemical binding]; other site 743720001466 thioredoxin 2; Provisional; Region: PRK10996 743720001467 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743720001468 catalytic residues [active] 743720001469 hydrolase; alpha/beta fold family protein; Region: PLN02652 743720001470 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 743720001471 BCCT family transporter; Region: BCCT; cl00569 743720001472 TIGR03549 family protein; Region: TIGR03549 743720001473 OsmC-like protein; Region: OsmC; cl00767 743720001474 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 743720001475 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 743720001476 aspartate racemase; Region: asp_race; TIGR00035 743720001477 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 743720001478 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 743720001479 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 743720001480 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 743720001481 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 743720001482 hypothetical protein; Provisional; Region: PRK11281 743720001483 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 743720001484 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743720001485 potassium/proton antiporter; Reviewed; Region: PRK05326 743720001486 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 743720001487 Transporter associated domain; Region: CorC_HlyC; cl08393 743720001488 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 743720001489 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 743720001490 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743720001491 catalytic residues [active] 743720001492 transcription termination factor Rho; Provisional; Region: rho; PRK09376 743720001493 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 743720001494 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 743720001495 RNA binding site [nucleotide binding]; other site 743720001496 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 743720001497 multimer interface [polypeptide binding]; other site 743720001498 Walker A motif; other site 743720001499 ATP binding site [chemical binding]; other site 743720001500 Walker B motif; other site 743720001501 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 743720001502 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 743720001503 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720001504 catalytic loop [active] 743720001505 iron binding site [ion binding]; other site 743720001506 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 743720001507 FAD binding pocket [chemical binding]; other site 743720001508 FAD binding motif [chemical binding]; other site 743720001509 phosphate binding motif [ion binding]; other site 743720001510 beta-alpha-beta structure motif; other site 743720001511 NAD binding pocket [chemical binding]; other site 743720001512 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 743720001513 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 743720001514 NAD(P) binding site [chemical binding]; other site 743720001515 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 743720001516 EVE domain; Region: EVE; cl00728 743720001517 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 743720001518 Cell division protein ZapA; Region: ZapA; cl01146 743720001519 TIGR02449 family protein; Region: TIGR02449 743720001520 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 743720001521 proline aminopeptidase P II; Provisional; Region: PRK10879 743720001522 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 743720001523 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 743720001524 active site 743720001525 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 743720001526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001527 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 743720001528 active site 2 [active] 743720001529 active site 1 [active] 743720001530 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 743720001531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720001533 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 743720001534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720001535 dimer interface [polypeptide binding]; other site 743720001536 conserved gate region; other site 743720001537 putative PBP binding loops; other site 743720001538 ABC-ATPase subunit interface; other site 743720001539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743720001540 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 743720001541 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 743720001542 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 743720001543 lipoyl attachment site [posttranslational modification]; other site 743720001544 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 743720001545 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 743720001546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720001547 dimerization interface [polypeptide binding]; other site 743720001548 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720001549 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720001550 dimer interface [polypeptide binding]; other site 743720001551 putative CheW interface [polypeptide binding]; other site 743720001552 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 743720001553 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 743720001554 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 743720001555 Walker A motif; other site 743720001556 ATP binding site [chemical binding]; other site 743720001557 Walker B motif; other site 743720001558 Protein of unknown function (DUF502); Region: DUF502; cl01107 743720001559 Uncharacterized conserved protein [Function unknown]; Region: COG3025 743720001560 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 743720001561 putative active site [active] 743720001562 putative metal binding residues [ion binding]; other site 743720001563 signature motif; other site 743720001564 putative triphosphate binding site [ion binding]; other site 743720001565 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 743720001566 Phosphate transporter family; Region: PHO4; cl00396 743720001567 Phosphate transporter family; Region: PHO4; cl00396 743720001568 acetylornithine deacetylase; Provisional; Region: PRK05111 743720001569 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 743720001570 metal binding site [ion binding]; metal-binding site 743720001571 putative dimer interface [polypeptide binding]; other site 743720001572 N-acetylglutamate synthase; Validated; Region: PRK05279 743720001573 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 743720001574 putative feedback inhibition sensing region; other site 743720001575 putative nucleotide binding site [chemical binding]; other site 743720001576 putative substrate binding site [chemical binding]; other site 743720001577 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720001578 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 743720001579 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 743720001580 metal binding site [ion binding]; metal-binding site 743720001581 dimer interface [polypeptide binding]; other site 743720001582 tRNA (uracil-5-)-methyltransferase; Region: trmA_only; TIGR02143 743720001583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720001584 S-adenosylmethionine binding site [chemical binding]; other site 743720001585 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 743720001586 Hsp70 protein; Region: HSP70; pfam00012 743720001587 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 743720001588 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743720001589 HSP70 interaction site [polypeptide binding]; other site 743720001590 enterobactin exporter EntS; Provisional; Region: PRK10489 743720001591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720001592 putative substrate translocation pore; other site 743720001593 putative diguanylate cyclase; Provisional; Region: PRK09776 743720001594 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 743720001595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720001596 dimer interface [polypeptide binding]; other site 743720001597 phosphorylation site [posttranslational modification] 743720001598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001599 ATP binding site [chemical binding]; other site 743720001600 Mg2+ binding site [ion binding]; other site 743720001601 G-X-G motif; other site 743720001602 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720001603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001604 active site 743720001605 phosphorylation site [posttranslational modification] 743720001606 intermolecular recognition site; other site 743720001607 dimerization interface [polypeptide binding]; other site 743720001608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001609 active site 743720001610 phosphorylation site [posttranslational modification] 743720001611 intermolecular recognition site; other site 743720001612 dimerization interface [polypeptide binding]; other site 743720001613 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001614 PAS fold; Region: PAS_3; pfam08447 743720001615 putative active site [active] 743720001616 heme pocket [chemical binding]; other site 743720001617 PAS fold; Region: PAS_4; pfam08448 743720001618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001619 putative active site [active] 743720001620 heme pocket [chemical binding]; other site 743720001621 histidine kinase; Provisional; Region: PRK13557 743720001622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001623 ATP binding site [chemical binding]; other site 743720001624 G-X-G motif; other site 743720001625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001626 active site 743720001627 intermolecular recognition site; other site 743720001628 dimerization interface [polypeptide binding]; other site 743720001629 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001631 active site 743720001632 phosphorylation site [posttranslational modification] 743720001633 intermolecular recognition site; other site 743720001634 dimerization interface [polypeptide binding]; other site 743720001635 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 743720001636 GAF domain; Region: GAF; cl15785 743720001637 Phytochrome region; Region: PHY; pfam00360 743720001638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720001639 dimer interface [polypeptide binding]; other site 743720001640 phosphorylation site [posttranslational modification] 743720001641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001642 ATP binding site [chemical binding]; other site 743720001643 G-X-G motif; other site 743720001644 SdiA-regulated; Region: SdiA-regulated; cd09971 743720001645 SdiA-regulated; Region: SdiA-regulated; pfam06977 743720001646 putative active site [active] 743720001647 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 743720001648 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 743720001649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720001650 S-adenosylmethionine binding site [chemical binding]; other site 743720001651 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 743720001652 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 743720001653 enoyl-CoA hydratase; Region: PLN02864 743720001654 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 743720001655 active site 2 [active] 743720001656 active site 1 [active] 743720001657 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720001658 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720001659 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 743720001660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001662 NAD(P) binding site [chemical binding]; other site 743720001663 active site 743720001664 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 743720001665 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720001666 dimer interface [polypeptide binding]; other site 743720001667 active site 743720001668 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 743720001669 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 743720001670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720001671 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 743720001672 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 743720001673 DNA binding site [nucleotide binding] 743720001674 active site 743720001675 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 743720001676 ATP binding site [chemical binding]; other site 743720001677 nitrite reductase subunit NirD; Provisional; Region: PRK14989 743720001678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720001679 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 743720001680 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 743720001681 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720001682 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 743720001683 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 743720001684 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 743720001685 active site 743720001686 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 743720001687 Catalytic domain of Protein Kinases; Region: PKc; cd00180 743720001688 active site 743720001689 ATP binding site [chemical binding]; other site 743720001690 substrate binding site [chemical binding]; other site 743720001691 activation loop (A-loop); other site 743720001692 Integral membrane protein TerC family; Region: TerC; cl10468 743720001693 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 743720001694 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 743720001695 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720001696 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720001697 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720001698 dimer interface [polypeptide binding]; other site 743720001699 putative CheW interface [polypeptide binding]; other site 743720001700 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720001701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720001702 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 743720001703 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720001704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720001705 DNA-binding site [nucleotide binding]; DNA binding site 743720001706 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720001707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720001708 homodimer interface [polypeptide binding]; other site 743720001709 catalytic residue [active] 743720001710 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 743720001711 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720001712 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720001713 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 743720001714 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 743720001715 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 743720001716 D-pathway; other site 743720001717 Putative ubiquinol binding site [chemical binding]; other site 743720001718 Low-spin heme (heme b) binding site [chemical binding]; other site 743720001719 Putative water exit pathway; other site 743720001720 Binuclear center (heme o3/CuB) [ion binding]; other site 743720001721 K-pathway; other site 743720001722 Putative proton exit pathway; other site 743720001723 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743720001724 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720001725 N-terminal plug; other site 743720001726 ligand-binding site [chemical binding]; other site 743720001727 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720001728 LysR family transcriptional regulator; Provisional; Region: PRK14997 743720001729 Helix-turn-helix domains; Region: HTH; cl00088 743720001730 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720001731 putative effector binding pocket; other site 743720001732 dimerization interface [polypeptide binding]; other site 743720001733 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720001734 PAS fold; Region: PAS_4; pfam08448 743720001735 PAS domain; Region: PAS_9; pfam13426 743720001736 sensory histidine kinase AtoS; Provisional; Region: PRK11360 743720001737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720001738 dimer interface [polypeptide binding]; other site 743720001739 phosphorylation site [posttranslational modification] 743720001740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001741 ATP binding site [chemical binding]; other site 743720001742 Mg2+ binding site [ion binding]; other site 743720001743 G-X-G motif; other site 743720001744 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001746 active site 743720001747 phosphorylation site [posttranslational modification] 743720001748 intermolecular recognition site; other site 743720001749 dimerization interface [polypeptide binding]; other site 743720001750 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 743720001751 Cytochrome c; Region: Cytochrom_C; cl11414 743720001752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001753 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 743720001754 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 743720001755 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 743720001756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001757 putative active site [active] 743720001758 heme pocket [chemical binding]; other site 743720001759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001760 PAS domain; Region: PAS_9; pfam13426 743720001761 putative active site [active] 743720001762 heme pocket [chemical binding]; other site 743720001763 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720001764 dimer interface [polypeptide binding]; other site 743720001765 putative CheW interface [polypeptide binding]; other site 743720001766 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 743720001767 sensory histidine kinase AtoS; Provisional; Region: PRK11360 743720001768 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 743720001769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001770 ATP binding site [chemical binding]; other site 743720001771 Mg2+ binding site [ion binding]; other site 743720001772 G-X-G motif; other site 743720001773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001774 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720001775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720001776 dimer interface [polypeptide binding]; other site 743720001777 conserved gate region; other site 743720001778 putative PBP binding loops; other site 743720001779 ABC-ATPase subunit interface; other site 743720001780 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720001781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720001782 dimer interface [polypeptide binding]; other site 743720001783 conserved gate region; other site 743720001784 putative PBP binding loops; other site 743720001785 ABC-ATPase subunit interface; other site 743720001786 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720001787 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720001788 substrate binding pocket [chemical binding]; other site 743720001789 membrane-bound complex binding site; other site 743720001790 hinge residues; other site 743720001791 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 743720001792 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 743720001793 Walker A/P-loop; other site 743720001794 ATP binding site [chemical binding]; other site 743720001795 Q-loop/lid; other site 743720001796 ABC transporter signature motif; other site 743720001797 Walker B; other site 743720001798 D-loop; other site 743720001799 H-loop/switch region; other site 743720001800 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001802 active site 743720001803 phosphorylation site [posttranslational modification] 743720001804 intermolecular recognition site; other site 743720001805 dimerization interface [polypeptide binding]; other site 743720001806 CHASE3 domain; Region: CHASE3; cl05000 743720001807 GAF domain; Region: GAF_2; pfam13185 743720001808 GAF domain; Region: GAF; cl15785 743720001809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720001810 dimer interface [polypeptide binding]; other site 743720001811 phosphorylation site [posttranslational modification] 743720001812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001813 ATP binding site [chemical binding]; other site 743720001814 Mg2+ binding site [ion binding]; other site 743720001815 G-X-G motif; other site 743720001816 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001818 active site 743720001819 phosphorylation site [posttranslational modification] 743720001820 intermolecular recognition site; other site 743720001821 dimerization interface [polypeptide binding]; other site 743720001822 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720001823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001824 active site 743720001825 phosphorylation site [posttranslational modification] 743720001826 intermolecular recognition site; other site 743720001827 dimerization interface [polypeptide binding]; other site 743720001828 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001830 active site 743720001831 phosphorylation site [posttranslational modification] 743720001832 intermolecular recognition site; other site 743720001833 dimerization interface [polypeptide binding]; other site 743720001834 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 743720001835 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 743720001836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001837 CheB methylesterase; Region: CheB_methylest; pfam01339 743720001838 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001840 active site 743720001841 phosphorylation site [posttranslational modification] 743720001842 intermolecular recognition site; other site 743720001843 dimerization interface [polypeptide binding]; other site 743720001844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720001845 dimer interface [polypeptide binding]; other site 743720001846 phosphorylation site [posttranslational modification] 743720001847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001848 ATP binding site [chemical binding]; other site 743720001849 Mg2+ binding site [ion binding]; other site 743720001850 G-X-G motif; other site 743720001851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001852 active site 743720001853 phosphorylation site [posttranslational modification] 743720001854 intermolecular recognition site; other site 743720001855 dimerization interface [polypeptide binding]; other site 743720001856 anthranilate synthase component I; Provisional; Region: PRK13565 743720001857 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 743720001858 chorismate binding enzyme; Region: Chorismate_bind; cl10555 743720001859 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 743720001860 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720001861 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720001862 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 743720001863 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743720001864 carboxyltransferase (CT) interaction site; other site 743720001865 biotinylation site [posttranslational modification]; other site 743720001866 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 743720001867 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 743720001868 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 743720001869 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 743720001870 LamB/YcsF family; Region: LamB_YcsF; cl00664 743720001871 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 743720001872 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720001873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720001874 DNA-binding site [nucleotide binding]; DNA binding site 743720001875 FCD domain; Region: FCD; cl11656 743720001876 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 743720001877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720001878 non-specific DNA binding site [nucleotide binding]; other site 743720001879 salt bridge; other site 743720001880 sequence-specific DNA binding site [nucleotide binding]; other site 743720001881 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 743720001882 Catalytic site [active] 743720001883 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 743720001884 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 743720001885 catalytic residue [active] 743720001886 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 743720001887 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 743720001888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720001889 Coenzyme A binding pocket [chemical binding]; other site 743720001890 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720001891 phosphoglycolate phosphatase; Provisional; Region: PRK13223 743720001892 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 743720001893 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 743720001894 glutamine binding [chemical binding]; other site 743720001895 catalytic triad [active] 743720001896 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 743720001897 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 743720001898 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 743720001899 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 743720001900 active site 743720001901 ribulose/triose binding site [chemical binding]; other site 743720001902 phosphate binding site [ion binding]; other site 743720001903 substrate (anthranilate) binding pocket [chemical binding]; other site 743720001904 product (indole) binding pocket [chemical binding]; other site 743720001905 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 743720001906 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 743720001907 dimerization interface [polypeptide binding]; other site 743720001908 active site 743720001909 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 743720001910 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 743720001911 amidase catalytic site [active] 743720001912 Zn binding residues [ion binding]; other site 743720001913 substrate binding site [chemical binding]; other site 743720001914 CobD/Cbib protein; Region: CobD_Cbib; cl00561 743720001915 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 743720001916 active site 743720001917 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 743720001918 AsmA-like C-terminal region; Region: AsmA_2; cl15864 743720001919 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 743720001920 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720001921 DNA binding site [nucleotide binding] 743720001922 domain linker motif; other site 743720001923 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 743720001924 dimerization interface [polypeptide binding]; other site 743720001925 ligand binding site [chemical binding]; other site 743720001926 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 743720001927 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 743720001928 active site 743720001929 phosphorylation site [posttranslational modification] 743720001930 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 743720001931 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 743720001932 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 743720001933 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 743720001934 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 743720001935 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 743720001936 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 743720001937 putative substrate binding site [chemical binding]; other site 743720001938 putative ATP binding site [chemical binding]; other site 743720001939 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 743720001940 P-loop; other site 743720001941 active site 743720001942 phosphorylation site [posttranslational modification] 743720001943 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 743720001944 P-loop; other site 743720001945 active site 743720001946 phosphorylation site [posttranslational modification] 743720001947 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 743720001948 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 743720001949 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 743720001950 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720001951 ligand binding site [chemical binding]; other site 743720001952 flexible hinge region; other site 743720001953 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 743720001954 putative switch regulator; other site 743720001955 non-specific DNA interactions [nucleotide binding]; other site 743720001956 DNA binding site [nucleotide binding] 743720001957 sequence specific DNA binding site [nucleotide binding]; other site 743720001958 putative cAMP binding site [chemical binding]; other site 743720001959 OsmC-like protein; Region: OsmC; cl00767 743720001960 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 743720001961 diiron binding motif [ion binding]; other site 743720001962 Ycf46; Provisional; Region: ycf46; CHL00195 743720001963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720001964 Walker A motif; other site 743720001965 ATP binding site [chemical binding]; other site 743720001966 Walker B motif; other site 743720001967 arginine finger; other site 743720001968 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 743720001969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001970 NAD(P) binding site [chemical binding]; other site 743720001971 active site 743720001972 Protein of unknown function (DUF805); Region: DUF805; cl01224 743720001973 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 743720001974 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 743720001975 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 743720001976 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 743720001977 putative peptidase; Provisional; Region: PRK11649 743720001978 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 743720001979 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 743720001980 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 743720001981 active site 743720001982 HIGH motif; other site 743720001983 dimer interface [polypeptide binding]; other site 743720001984 KMSKS motif; other site 743720001985 Type III pantothenate kinase; Region: Pan_kinase; cl09130 743720001986 Sporulation related domain; Region: SPOR; cl10051 743720001987 elongation factor Tu; Reviewed; Region: PRK00049 743720001988 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 743720001989 G1 box; other site 743720001990 GEF interaction site [polypeptide binding]; other site 743720001991 GTP/Mg2+ binding site [chemical binding]; other site 743720001992 Switch I region; other site 743720001993 G2 box; other site 743720001994 G3 box; other site 743720001995 Switch II region; other site 743720001996 G4 box; other site 743720001997 G5 box; other site 743720001998 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 743720001999 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 743720002000 Antibiotic Binding Site [chemical binding]; other site 743720002001 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 743720002002 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 743720002003 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 743720002004 putative homodimer interface [polypeptide binding]; other site 743720002005 KOW motif; Region: KOW; cl00354 743720002006 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 743720002007 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 743720002008 23S rRNA interface [nucleotide binding]; other site 743720002009 L7/L12 interface [polypeptide binding]; other site 743720002010 putative thiostrepton binding site; other site 743720002011 L25 interface [polypeptide binding]; other site 743720002012 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 743720002013 mRNA/rRNA interface [nucleotide binding]; other site 743720002014 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 743720002015 23S rRNA interface [nucleotide binding]; other site 743720002016 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 743720002017 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 743720002018 core dimer interface [polypeptide binding]; other site 743720002019 peripheral dimer interface [polypeptide binding]; other site 743720002020 L10 interface [polypeptide binding]; other site 743720002021 L11 interface [polypeptide binding]; other site 743720002022 putative EF-Tu interaction site [polypeptide binding]; other site 743720002023 putative EF-G interaction site [polypeptide binding]; other site 743720002024 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 743720002025 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 743720002026 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 743720002027 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 743720002028 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 743720002029 RPB11 interaction site [polypeptide binding]; other site 743720002030 RPB12 interaction site [polypeptide binding]; other site 743720002031 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 743720002032 RPB3 interaction site [polypeptide binding]; other site 743720002033 RPB1 interaction site [polypeptide binding]; other site 743720002034 RPB11 interaction site [polypeptide binding]; other site 743720002035 RPB10 interaction site [polypeptide binding]; other site 743720002036 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 743720002037 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 743720002038 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 743720002039 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 743720002040 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 743720002041 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 743720002042 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 743720002043 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 743720002044 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 743720002045 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 743720002046 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 743720002047 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 743720002048 DNA binding site [nucleotide binding] 743720002049 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 743720002050 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 743720002051 S17 interaction site [polypeptide binding]; other site 743720002052 S8 interaction site; other site 743720002053 16S rRNA interaction site [nucleotide binding]; other site 743720002054 streptomycin interaction site [chemical binding]; other site 743720002055 23S rRNA interaction site [nucleotide binding]; other site 743720002056 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 743720002057 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 743720002058 elongation factor G; Reviewed; Region: PRK00007 743720002059 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 743720002060 G1 box; other site 743720002061 putative GEF interaction site [polypeptide binding]; other site 743720002062 GTP/Mg2+ binding site [chemical binding]; other site 743720002063 Switch I region; other site 743720002064 G2 box; other site 743720002065 G3 box; other site 743720002066 Switch II region; other site 743720002067 G4 box; other site 743720002068 G5 box; other site 743720002069 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 743720002070 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 743720002071 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 743720002072 elongation factor Tu; Reviewed; Region: PRK00049 743720002073 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 743720002074 G1 box; other site 743720002075 GEF interaction site [polypeptide binding]; other site 743720002076 GTP/Mg2+ binding site [chemical binding]; other site 743720002077 Switch I region; other site 743720002078 G2 box; other site 743720002079 G3 box; other site 743720002080 Switch II region; other site 743720002081 G4 box; other site 743720002082 G5 box; other site 743720002083 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 743720002084 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 743720002085 Antibiotic Binding Site [chemical binding]; other site 743720002086 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 743720002087 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 743720002088 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 743720002089 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 743720002090 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 743720002091 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 743720002092 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 743720002093 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 743720002094 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 743720002095 protein-rRNA interface [nucleotide binding]; other site 743720002096 putative translocon binding site; other site 743720002097 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 743720002098 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 743720002099 G-X-X-G motif; other site 743720002100 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 743720002101 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 743720002102 23S rRNA interface [nucleotide binding]; other site 743720002103 5S rRNA interface [nucleotide binding]; other site 743720002104 putative antibiotic binding site [chemical binding]; other site 743720002105 L25 interface [polypeptide binding]; other site 743720002106 L27 interface [polypeptide binding]; other site 743720002107 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 743720002108 23S rRNA interface [nucleotide binding]; other site 743720002109 putative translocon interaction site; other site 743720002110 signal recognition particle (SRP54) interaction site; other site 743720002111 L23 interface [polypeptide binding]; other site 743720002112 trigger factor interaction site; other site 743720002113 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 743720002114 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 743720002115 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 743720002116 KOW motif; Region: KOW; cl00354 743720002117 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 743720002118 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 743720002119 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 743720002120 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 743720002121 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 743720002122 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 743720002123 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 743720002124 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 743720002125 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 743720002126 5S rRNA interface [nucleotide binding]; other site 743720002127 23S rRNA interface [nucleotide binding]; other site 743720002128 L5 interface [polypeptide binding]; other site 743720002129 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 743720002130 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 743720002131 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 743720002132 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 743720002133 23S rRNA binding site [nucleotide binding]; other site 743720002134 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 743720002135 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 743720002136 SecY translocase; Region: SecY; pfam00344 743720002137 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 743720002138 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 743720002139 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 743720002140 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 743720002141 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 743720002142 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 743720002143 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720002144 RNA binding surface [nucleotide binding]; other site 743720002145 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 743720002146 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 743720002147 alphaNTD homodimer interface [polypeptide binding]; other site 743720002148 alphaNTD - beta interaction site [polypeptide binding]; other site 743720002149 alphaNTD - beta' interaction site [polypeptide binding]; other site 743720002150 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 743720002151 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 743720002152 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 743720002153 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 743720002154 dimer interface [polypeptide binding]; other site 743720002155 active site 743720002156 heme binding site [chemical binding]; other site 743720002157 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 743720002158 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 743720002159 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 743720002160 heme binding site [chemical binding]; other site 743720002161 ferroxidase pore; other site 743720002162 ferroxidase diiron center [ion binding]; other site 743720002163 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 743720002164 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 743720002165 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 743720002166 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 743720002167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002168 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720002169 putative substrate translocation pore; other site 743720002170 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 743720002171 dimer interface [polypeptide binding]; other site 743720002172 ssDNA binding site [nucleotide binding]; other site 743720002173 tetramer (dimer of dimers) interface [polypeptide binding]; other site 743720002174 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 743720002175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002176 NAD(P) binding site [chemical binding]; other site 743720002177 active site 743720002178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002179 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 743720002180 NAD(P) binding site [chemical binding]; other site 743720002181 active site 743720002182 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 743720002183 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 743720002184 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 743720002185 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743720002186 FtsX-like permease family; Region: FtsX; cl15850 743720002187 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 743720002188 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 743720002189 Walker A/P-loop; other site 743720002190 ATP binding site [chemical binding]; other site 743720002191 Q-loop/lid; other site 743720002192 ABC transporter signature motif; other site 743720002193 Walker B; other site 743720002194 D-loop; other site 743720002195 H-loop/switch region; other site 743720002196 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 743720002197 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 743720002198 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 743720002199 Predicted methyltransferase [General function prediction only]; Region: COG3897 743720002200 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 743720002201 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 743720002202 ATP cone domain; Region: ATP-cone; pfam03477 743720002203 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 743720002204 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 743720002205 catalytic motif [active] 743720002206 Zn binding site [ion binding]; other site 743720002207 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 743720002208 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 743720002209 active site 743720002210 homopentamer interface [polypeptide binding]; other site 743720002211 dimer interface [polypeptide binding]; other site 743720002212 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 743720002213 Lumazine binding domain; Region: Lum_binding; pfam00677 743720002214 Lumazine binding domain; Region: Lum_binding; pfam00677 743720002215 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 743720002216 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 743720002217 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 743720002218 dimerization interface [polypeptide binding]; other site 743720002219 active site 743720002220 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 743720002221 homopentamer interface [polypeptide binding]; other site 743720002222 active site 743720002223 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 743720002224 putative RNA binding site [nucleotide binding]; other site 743720002225 thiamine monophosphate kinase; Provisional; Region: PRK05731 743720002226 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 743720002227 ATP binding site [chemical binding]; other site 743720002228 dimerization interface [polypeptide binding]; other site 743720002229 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 743720002230 tetramer interfaces [polypeptide binding]; other site 743720002231 binuclear metal-binding site [ion binding]; other site 743720002232 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720002233 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 743720002234 catalytic motif [active] 743720002235 Catalytic residue [active] 743720002236 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 743720002237 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 743720002238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720002239 dimer interface [polypeptide binding]; other site 743720002240 conserved gate region; other site 743720002241 putative PBP binding loops; other site 743720002242 ABC-ATPase subunit interface; other site 743720002243 NMT1-like family; Region: NMT1_2; cl15260 743720002244 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 743720002245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720002246 dimer interface [polypeptide binding]; other site 743720002247 conserved gate region; other site 743720002248 ABC-ATPase subunit interface; other site 743720002249 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 743720002250 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 743720002251 Walker A/P-loop; other site 743720002252 ATP binding site [chemical binding]; other site 743720002253 Q-loop/lid; other site 743720002254 ABC transporter signature motif; other site 743720002255 Walker B; other site 743720002256 D-loop; other site 743720002257 H-loop/switch region; other site 743720002258 FOG: CBS domain [General function prediction only]; Region: COG0517 743720002259 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 743720002260 Cupin domain; Region: Cupin_2; cl09118 743720002261 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 743720002262 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 743720002263 NAD(P) binding site [chemical binding]; other site 743720002264 catalytic residues [active] 743720002265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720002267 putative substrate translocation pore; other site 743720002268 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 743720002269 PLD-like domain; Region: PLDc_2; pfam13091 743720002270 putative active site [active] 743720002271 catalytic site [active] 743720002272 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 743720002273 PLD-like domain; Region: PLDc_2; pfam13091 743720002274 putative active site [active] 743720002275 catalytic site [active] 743720002276 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720002277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720002278 DNA-binding site [nucleotide binding]; DNA binding site 743720002279 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720002280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720002281 homodimer interface [polypeptide binding]; other site 743720002282 catalytic residue [active] 743720002283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002284 FAD dependent oxidoreductase; Region: DAO; pfam01266 743720002285 Flagellin N-methylase; Region: FliB; cl00497 743720002286 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743720002287 Helix-turn-helix domains; Region: HTH; cl00088 743720002288 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 743720002289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002290 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 743720002291 homotrimer interaction site [polypeptide binding]; other site 743720002292 putative active site [active] 743720002293 alanine racemase; Reviewed; Region: dadX; PRK03646 743720002294 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 743720002295 active site 743720002296 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720002297 substrate binding site [chemical binding]; other site 743720002298 catalytic residues [active] 743720002299 dimer interface [polypeptide binding]; other site 743720002300 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 743720002301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720002302 non-specific DNA binding site [nucleotide binding]; other site 743720002303 salt bridge; other site 743720002304 sequence-specific DNA binding site [nucleotide binding]; other site 743720002305 Cupin domain; Region: Cupin_2; cl09118 743720002306 Cytochrome c; Region: Cytochrom_C; cl11414 743720002307 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 743720002308 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 743720002309 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 743720002310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720002311 active site 743720002312 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 743720002313 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 743720002314 Family description; Region: UvrD_C_2; cl15862 743720002315 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720002316 metal binding site [ion binding]; metal-binding site 743720002317 active site 743720002318 I-site; other site 743720002319 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720002320 multidrug efflux protein NorA; Provisional; Region: PRK00187 743720002321 MatE; Region: MatE; cl10513 743720002322 MatE; Region: MatE; cl10513 743720002323 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720002324 Helix-turn-helix domains; Region: HTH; cl00088 743720002325 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720002326 dimerization interface [polypeptide binding]; other site 743720002327 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720002328 dimerization interface [polypeptide binding]; other site 743720002329 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720002330 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720002331 dimer interface [polypeptide binding]; other site 743720002332 putative CheW interface [polypeptide binding]; other site 743720002333 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 743720002334 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 743720002335 dimer interface [polypeptide binding]; other site 743720002336 active site 743720002337 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720002338 catalytic residues [active] 743720002339 substrate binding site [chemical binding]; other site 743720002340 AAA domain; Region: AAA_32; pfam13654 743720002341 ATP-dependent protease Lon; Provisional; Region: PRK13765 743720002342 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 743720002343 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 743720002344 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 743720002345 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 743720002346 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 743720002347 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 743720002348 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 743720002349 substrate binding pocket [chemical binding]; other site 743720002350 chain length determination region; other site 743720002351 substrate-Mg2+ binding site; other site 743720002352 catalytic residues [active] 743720002353 aspartate-rich region 1; other site 743720002354 active site lid residues [active] 743720002355 aspartate-rich region 2; other site 743720002356 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 743720002357 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 743720002358 GTPase CgtA; Reviewed; Region: obgE; PRK12298 743720002359 GTP1/OBG; Region: GTP1_OBG; pfam01018 743720002360 Obg GTPase; Region: Obg; cd01898 743720002361 G1 box; other site 743720002362 GTP/Mg2+ binding site [chemical binding]; other site 743720002363 Switch I region; other site 743720002364 G2 box; other site 743720002365 G3 box; other site 743720002366 Switch II region; other site 743720002367 G4 box; other site 743720002368 G5 box; other site 743720002369 gamma-glutamyl kinase; Provisional; Region: PRK05429 743720002370 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 743720002371 nucleotide binding site [chemical binding]; other site 743720002372 homotetrameric interface [polypeptide binding]; other site 743720002373 putative phosphate binding site [ion binding]; other site 743720002374 putative allosteric binding site; other site 743720002375 PUA domain; Region: PUA; cl00607 743720002376 CreA protein; Region: CreA; pfam05981 743720002377 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720002378 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720002379 dimerization interface [polypeptide binding]; other site 743720002380 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720002381 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720002382 dimer interface [polypeptide binding]; other site 743720002383 putative CheW interface [polypeptide binding]; other site 743720002384 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 743720002385 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 743720002386 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 743720002387 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 743720002388 active site 743720002389 Riboflavin kinase; Region: Flavokinase; cl03312 743720002390 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 743720002391 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743720002392 active site 743720002393 HIGH motif; other site 743720002394 nucleotide binding site [chemical binding]; other site 743720002395 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 743720002396 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 743720002397 active site 743720002398 KMSKS motif; other site 743720002399 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 743720002400 tRNA binding surface [nucleotide binding]; other site 743720002401 anticodon binding site; other site 743720002402 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 743720002403 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 743720002404 lipoprotein signal peptidase; Provisional; Region: PRK14787 743720002405 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 743720002406 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 743720002407 LytB protein; Region: LYTB; cl00507 743720002408 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 743720002409 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 743720002410 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 743720002411 dimer interface [polypeptide binding]; other site 743720002412 substrate binding site [chemical binding]; other site 743720002413 metal binding sites [ion binding]; metal-binding site 743720002414 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 743720002415 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743720002416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720002417 Coenzyme A binding pocket [chemical binding]; other site 743720002418 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 743720002419 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743720002420 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743720002421 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743720002422 aromatic acid decarboxylase; Validated; Region: PRK05920 743720002423 Flavoprotein; Region: Flavoprotein; cl08021 743720002424 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 743720002425 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 743720002426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002427 Uncharacterized conserved protein [Function unknown]; Region: COG1739 743720002428 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 743720002429 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 743720002430 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 743720002431 Helix-turn-helix domains; Region: HTH; cl00088 743720002432 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 743720002433 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743720002434 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 743720002435 active site 743720002436 catalytic tetrad [active] 743720002437 transcription termination factor Rho; Provisional; Region: PRK12678 743720002438 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 743720002439 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720002440 Helix-turn-helix domains; Region: HTH; cl00088 743720002441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720002442 dimerization interface [polypeptide binding]; other site 743720002443 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 743720002444 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720002445 inhibitor-cofactor binding pocket; inhibition site 743720002446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720002447 catalytic residue [active] 743720002448 Cupin domain; Region: Cupin_2; cl09118 743720002449 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 743720002450 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720002451 tetrameric interface [polypeptide binding]; other site 743720002452 NAD binding site [chemical binding]; other site 743720002453 catalytic residues [active] 743720002454 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 743720002455 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 743720002456 putative metal binding site [ion binding]; other site 743720002457 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 743720002458 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 743720002459 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 743720002460 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 743720002461 dimerization interface [polypeptide binding]; other site 743720002462 ligand binding site [chemical binding]; other site 743720002463 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 743720002464 TM-ABC transporter signature motif; other site 743720002465 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 743720002466 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 743720002467 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 743720002468 TM-ABC transporter signature motif; other site 743720002469 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 743720002470 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 743720002471 Walker A/P-loop; other site 743720002472 ATP binding site [chemical binding]; other site 743720002473 Q-loop/lid; other site 743720002474 ABC transporter signature motif; other site 743720002475 Walker B; other site 743720002476 D-loop; other site 743720002477 H-loop/switch region; other site 743720002478 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 743720002479 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 743720002480 Walker A/P-loop; other site 743720002481 ATP binding site [chemical binding]; other site 743720002482 Q-loop/lid; other site 743720002483 ABC transporter signature motif; other site 743720002484 Walker B; other site 743720002485 D-loop; other site 743720002486 H-loop/switch region; other site 743720002487 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 743720002488 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 743720002489 Helix-turn-helix domains; Region: HTH; cl00088 743720002490 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 743720002491 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 743720002492 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720002493 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 743720002494 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 743720002495 active site 743720002496 HIGH motif; other site 743720002497 dimer interface [polypeptide binding]; other site 743720002498 KMSKS motif; other site 743720002499 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 743720002500 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720002501 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 743720002502 conserved cys residue [active] 743720002503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002505 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 743720002506 Active_site [active] 743720002507 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 743720002508 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743720002509 active site 743720002510 catalytic tetrad [active] 743720002511 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 743720002512 23S rRNA interface [nucleotide binding]; other site 743720002513 L3 interface [polypeptide binding]; other site 743720002514 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 743720002515 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 743720002516 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 743720002517 [2Fe-2S] cluster binding site [ion binding]; other site 743720002518 cytochrome b; Provisional; Region: CYTB; MTH00145 743720002519 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 743720002520 Qi binding site; other site 743720002521 intrachain domain interface; other site 743720002522 interchain domain interface [polypeptide binding]; other site 743720002523 heme bH binding site [chemical binding]; other site 743720002524 heme bL binding site [chemical binding]; other site 743720002525 Qo binding site; other site 743720002526 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 743720002527 interchain domain interface [polypeptide binding]; other site 743720002528 intrachain domain interface; other site 743720002529 Qi binding site; other site 743720002530 Qo binding site; other site 743720002531 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 743720002532 stringent starvation protein A; Provisional; Region: sspA; PRK09481 743720002533 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 743720002534 C-terminal domain interface [polypeptide binding]; other site 743720002535 putative GSH binding site (G-site) [chemical binding]; other site 743720002536 dimer interface [polypeptide binding]; other site 743720002537 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 743720002538 dimer interface [polypeptide binding]; other site 743720002539 N-terminal domain interface [polypeptide binding]; other site 743720002540 Stringent starvation protein B; Region: SspB; cl01120 743720002541 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 743720002542 BON domain; Region: BON; cl02771 743720002543 CsbD-like; Region: CsbD; cl15799 743720002544 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 743720002545 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 743720002546 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720002547 catalytic residue [active] 743720002548 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720002549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720002550 DNA-binding site [nucleotide binding]; DNA binding site 743720002551 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720002552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720002553 homodimer interface [polypeptide binding]; other site 743720002554 catalytic residue [active] 743720002555 AMP nucleosidase; Provisional; Region: PRK08292 743720002556 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 743720002557 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 743720002558 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 743720002559 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720002560 Zn2+ binding site [ion binding]; other site 743720002561 Mg2+ binding site [ion binding]; other site 743720002562 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 743720002563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002564 putative substrate translocation pore; other site 743720002565 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 743720002566 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 743720002567 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 743720002568 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 743720002569 Walker A/P-loop; other site 743720002570 ATP binding site [chemical binding]; other site 743720002571 Q-loop/lid; other site 743720002572 ABC transporter signature motif; other site 743720002573 Walker B; other site 743720002574 D-loop; other site 743720002575 H-loop/switch region; other site 743720002576 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720002577 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720002578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720002579 dimer interface [polypeptide binding]; other site 743720002580 conserved gate region; other site 743720002581 putative PBP binding loops; other site 743720002582 ABC-ATPase subunit interface; other site 743720002583 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720002584 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720002585 substrate binding pocket [chemical binding]; other site 743720002586 membrane-bound complex binding site; other site 743720002587 hinge residues; other site 743720002588 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720002589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720002590 DNA-binding site [nucleotide binding]; DNA binding site 743720002591 FCD domain; Region: FCD; cl11656 743720002592 amidase; Provisional; Region: PRK07869 743720002593 Amidase; Region: Amidase; cl11426 743720002594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002595 putative substrate translocation pore; other site 743720002596 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 743720002597 transcriptional regulator EutR; Provisional; Region: PRK10130 743720002598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002599 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 743720002600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002601 putative substrate translocation pore; other site 743720002602 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 743720002603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720002604 dimer interface [polypeptide binding]; other site 743720002605 phosphorylation site [posttranslational modification] 743720002606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720002607 ATP binding site [chemical binding]; other site 743720002608 Mg2+ binding site [ion binding]; other site 743720002609 G-X-G motif; other site 743720002610 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 743720002611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720002612 active site 743720002613 phosphorylation site [posttranslational modification] 743720002614 intermolecular recognition site; other site 743720002615 dimerization interface [polypeptide binding]; other site 743720002616 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720002617 DNA binding site [nucleotide binding] 743720002618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002620 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 743720002621 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 743720002622 Walker A/P-loop; other site 743720002623 ATP binding site [chemical binding]; other site 743720002624 Q-loop/lid; other site 743720002625 ABC transporter signature motif; other site 743720002626 Walker B; other site 743720002627 D-loop; other site 743720002628 H-loop/switch region; other site 743720002629 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720002630 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 743720002631 Walker A/P-loop; other site 743720002632 ATP binding site [chemical binding]; other site 743720002633 Q-loop/lid; other site 743720002634 ABC transporter signature motif; other site 743720002635 Walker B; other site 743720002636 D-loop; other site 743720002637 H-loop/switch region; other site 743720002638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743720002639 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 743720002640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720002641 dimer interface [polypeptide binding]; other site 743720002642 conserved gate region; other site 743720002643 putative PBP binding loops; other site 743720002644 ABC-ATPase subunit interface; other site 743720002645 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 743720002646 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 743720002647 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720002648 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720002649 dimerization interface [polypeptide binding]; other site 743720002650 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720002651 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720002652 dimer interface [polypeptide binding]; other site 743720002653 putative CheW interface [polypeptide binding]; other site 743720002654 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 743720002655 putative active site [active] 743720002656 Protein of unknown function DUF91; Region: DUF91; cl00709 743720002657 Restriction endonuclease; Region: Mrr_cat; cl00516 743720002658 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 743720002659 OpgC protein; Region: OpgC_C; cl00792 743720002660 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 743720002661 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 743720002662 Cupin domain; Region: Cupin_2; cl09118 743720002663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002664 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720002665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002666 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720002667 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 743720002668 conserved cys residue [active] 743720002669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002670 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 743720002671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002672 NAD(P) binding site [chemical binding]; other site 743720002673 active site 743720002674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002675 NAD(P) binding site [chemical binding]; other site 743720002676 active site 743720002677 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 743720002678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 743720002679 Cation efflux family; Region: Cation_efflux; cl00316 743720002680 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 743720002681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720002682 ATP binding site [chemical binding]; other site 743720002683 putative Mg++ binding site [ion binding]; other site 743720002684 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720002685 nucleotide binding region [chemical binding]; other site 743720002686 ATP-binding site [chemical binding]; other site 743720002687 Helicase associated domain (HA2); Region: HA2; cl04503 743720002688 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 743720002689 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 743720002690 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 743720002691 active site 743720002692 tetramer interface [polypeptide binding]; other site 743720002693 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743720002694 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720002695 DNA binding site [nucleotide binding] 743720002696 domain linker motif; other site 743720002697 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 743720002698 putative dimerization interface [polypeptide binding]; other site 743720002699 putative ligand binding site [chemical binding]; other site 743720002700 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 743720002701 LabA_like proteins; Region: LabA_like/DUF88; cl10034 743720002702 putative metal binding site [ion binding]; other site 743720002703 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 743720002704 active site 743720002705 substrate binding site [chemical binding]; other site 743720002706 catalytic site [active] 743720002707 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743720002708 DEAD-like helicases superfamily; Region: DEXDc; smart00487 743720002709 ATP binding site [chemical binding]; other site 743720002710 Mg++ binding site [ion binding]; other site 743720002711 motif III; other site 743720002712 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720002713 nucleotide binding region [chemical binding]; other site 743720002714 ATP-binding site [chemical binding]; other site 743720002715 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 743720002716 active site 743720002717 metal binding site [ion binding]; metal-binding site 743720002718 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720002719 HI0933-like protein; Region: HI0933_like; pfam03486 743720002720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720002721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002722 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 743720002723 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 743720002724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743720002725 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720002726 acyl-CoA thioesterase II; Provisional; Region: PRK10526 743720002727 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 743720002728 active site 743720002729 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 743720002730 catalytic triad [active] 743720002731 dimer interface [polypeptide binding]; other site 743720002732 Spore Coat Protein U domain; Region: SCPU; cl02253 743720002733 Spore Coat Protein U domain; Region: SCPU; cl02253 743720002734 Spore Coat Protein U domain; Region: SCPU; cl02253 743720002735 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 743720002736 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 743720002737 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 743720002738 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 743720002739 PapC C-terminal domain; Region: PapC_C; pfam13953 743720002740 Spore Coat Protein U domain; Region: SCPU; cl02253 743720002741 Spore Coat Protein U domain; Region: SCPU; cl02253 743720002742 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 743720002743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720002744 active site 743720002745 motif I; other site 743720002746 motif II; other site 743720002747 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 743720002748 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 743720002749 DNA binding residues [nucleotide binding] 743720002750 dimer interface [polypeptide binding]; other site 743720002751 copper binding site [ion binding]; other site 743720002752 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743720002753 metal-binding site [ion binding] 743720002754 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 743720002755 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743720002756 metal-binding site [ion binding] 743720002757 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743720002758 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 743720002759 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 743720002760 Helix-turn-helix domains; Region: HTH; cl00088 743720002761 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 743720002762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002763 putative substrate translocation pore; other site 743720002764 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720002765 ligand binding site [chemical binding]; other site 743720002766 flexible hinge region; other site 743720002767 TfoX N-terminal domain; Region: TfoX_N; cl01167 743720002768 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 743720002769 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 743720002770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 743720002771 AAA domain; Region: AAA_33; pfam13671 743720002772 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 743720002773 ATP-binding site [chemical binding]; other site 743720002774 Gluconate-6-phosphate binding site [chemical binding]; other site 743720002775 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 743720002776 Transglycosylase; Region: Transgly; cl07896 743720002777 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720002778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720002779 TPR motif; other site 743720002780 binding surface 743720002781 tRNA pseudouridine synthase C; Region: DUF446; cl01187 743720002782 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720002783 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 743720002784 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 743720002785 PYR/PP interface [polypeptide binding]; other site 743720002786 dimer interface [polypeptide binding]; other site 743720002787 TPP binding site [chemical binding]; other site 743720002788 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 743720002789 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 743720002790 TPP-binding site [chemical binding]; other site 743720002791 dimer interface [polypeptide binding]; other site 743720002792 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 743720002793 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 743720002794 putative valine binding site [chemical binding]; other site 743720002795 dimer interface [polypeptide binding]; other site 743720002796 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 743720002797 Helix-turn-helix domains; Region: HTH; cl00088 743720002798 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 743720002799 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 743720002800 putative dimerization interface [polypeptide binding]; other site 743720002801 ketol-acid reductoisomerase; Provisional; Region: PRK05479 743720002802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002803 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 743720002804 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 743720002805 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 743720002806 TMAO/DMSO reductase; Reviewed; Region: PRK05363 743720002807 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 743720002808 Moco binding site; other site 743720002809 metal coordination site [ion binding]; other site 743720002810 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 743720002811 Paraquat-inducible protein A; Region: PqiA; pfam04403 743720002812 Paraquat-inducible protein A; Region: PqiA; pfam04403 743720002813 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 743720002814 mce related protein; Region: MCE; pfam02470 743720002815 mce related protein; Region: MCE; pfam02470 743720002816 mce related protein; Region: MCE; pfam02470 743720002817 mce related protein; Region: MCE; pfam02470 743720002818 mce related protein; Region: MCE; pfam02470 743720002819 mce related protein; Region: MCE; pfam02470 743720002820 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 743720002821 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 743720002822 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 743720002823 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 743720002824 dimer interface [polypeptide binding]; other site 743720002825 active site 743720002826 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720002827 catalytic residues [active] 743720002828 substrate binding site [chemical binding]; other site 743720002829 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 743720002830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002831 NAD(P) binding pocket [chemical binding]; other site 743720002832 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720002833 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720002834 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720002835 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720002836 dimer interface [polypeptide binding]; other site 743720002837 putative CheW interface [polypeptide binding]; other site 743720002838 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 743720002839 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 743720002840 Citrate transporter; Region: CitMHS; pfam03600 743720002841 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 743720002842 Helix-turn-helix domains; Region: HTH; cl00088 743720002843 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 743720002844 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720002845 dimerization interface [polypeptide binding]; other site 743720002846 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 743720002847 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720002848 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 743720002849 active site clefts [active] 743720002850 zinc binding site [ion binding]; other site 743720002851 dimer interface [polypeptide binding]; other site 743720002852 EamA-like transporter family; Region: EamA; cl01037 743720002853 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 743720002854 EamA-like transporter family; Region: EamA; cl01037 743720002855 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 743720002856 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 743720002857 intersubunit interface [polypeptide binding]; other site 743720002858 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 743720002859 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 743720002860 PhnA protein; Region: PhnA; pfam03831 743720002861 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 743720002862 homotrimer interaction site [polypeptide binding]; other site 743720002863 putative active site [active] 743720002864 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 743720002865 Late embryogenesis abundant protein; Region: LEA_2; cl12118 743720002866 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 743720002867 Helix-turn-helix domains; Region: HTH; cl00088 743720002868 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 743720002869 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 743720002870 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720002871 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720002872 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 743720002873 Protein export membrane protein; Region: SecD_SecF; cl14618 743720002874 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 743720002875 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 743720002876 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 743720002877 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 743720002878 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 743720002879 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 743720002880 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720002881 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720002882 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720002883 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 743720002884 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 743720002885 active site 743720002886 Transmembrane secretion effector; Region: MFS_3; pfam05977 743720002887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002888 putative substrate translocation pore; other site 743720002889 Isochorismatase family; Region: Isochorismatase; pfam00857 743720002890 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 743720002891 catalytic triad [active] 743720002892 dimer interface [polypeptide binding]; other site 743720002893 conserved cis-peptide bond; other site 743720002894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720002895 Helix-turn-helix domains; Region: HTH; cl00088 743720002896 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 743720002897 putative substrate binding pocket [chemical binding]; other site 743720002898 putative dimerization interface [polypeptide binding]; other site 743720002899 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720002900 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 743720002901 conserved cys residue [active] 743720002902 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002903 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720002904 DNA binding site [nucleotide binding] 743720002905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720002906 Predicted ATPase [General function prediction only]; Region: COG3903 743720002907 Walker A motif; other site 743720002908 ATP binding site [chemical binding]; other site 743720002909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002910 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720002911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720002913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720002914 active site 743720002915 phosphorylation site [posttranslational modification] 743720002916 intermolecular recognition site; other site 743720002917 dimerization interface [polypeptide binding]; other site 743720002918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720002919 DNA binding residues [nucleotide binding] 743720002920 dimerization interface [polypeptide binding]; other site 743720002921 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 743720002922 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 743720002923 Histidine kinase; Region: HisKA_3; pfam07730 743720002924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720002925 ATP binding site [chemical binding]; other site 743720002926 Mg2+ binding site [ion binding]; other site 743720002927 G-X-G motif; other site 743720002928 Excalibur calcium-binding domain; Region: Excalibur; cl05460 743720002929 Fic/DOC family; Region: Fic; cl00960 743720002930 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 743720002931 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720002932 PAS fold; Region: PAS_3; pfam08447 743720002933 putative active site [active] 743720002934 heme pocket [chemical binding]; other site 743720002935 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720002936 PAS fold; Region: PAS_3; pfam08447 743720002937 putative active site [active] 743720002938 heme pocket [chemical binding]; other site 743720002939 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720002940 metal binding site [ion binding]; metal-binding site 743720002941 active site 743720002942 I-site; other site 743720002943 GTP-binding protein YchF; Reviewed; Region: PRK09601 743720002944 YchF GTPase; Region: YchF; cd01900 743720002945 G1 box; other site 743720002946 GTP/Mg2+ binding site [chemical binding]; other site 743720002947 Switch I region; other site 743720002948 G2 box; other site 743720002949 Switch II region; other site 743720002950 G3 box; other site 743720002951 G4 box; other site 743720002952 G5 box; other site 743720002953 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 743720002954 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 743720002955 putative active site [active] 743720002956 catalytic residue [active] 743720002957 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 743720002958 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 743720002959 5S rRNA interface [nucleotide binding]; other site 743720002960 CTC domain interface [polypeptide binding]; other site 743720002961 L16 interface [polypeptide binding]; other site 743720002962 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 743720002963 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 743720002964 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720002965 active site 743720002966 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 743720002967 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 743720002968 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 743720002969 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 743720002970 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 743720002971 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 743720002972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720002973 TPR motif; other site 743720002974 binding surface 743720002975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720002976 binding surface 743720002977 TPR motif; other site 743720002978 Tetratricopeptide repeat; Region: TPR_12; pfam13424 743720002979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720002980 binding surface 743720002981 TPR motif; other site 743720002982 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 743720002983 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 743720002984 tRNA; other site 743720002985 putative tRNA binding site [nucleotide binding]; other site 743720002986 putative NADP binding site [chemical binding]; other site 743720002987 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 743720002988 peptide chain release factor 1; Validated; Region: prfA; PRK00591 743720002989 RF-1 domain; Region: RF-1; cl02875 743720002990 RF-1 domain; Region: RF-1; cl02875 743720002991 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 743720002992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002993 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 743720002994 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 743720002995 ATP binding site [chemical binding]; other site 743720002996 substrate interface [chemical binding]; other site 743720002997 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 743720002998 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 743720002999 Flagellin N-methylase; Region: FliB; cl00497 743720003000 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 743720003001 short chain dehydrogenase; Provisional; Region: PRK08251 743720003002 classical (c) SDRs; Region: SDR_c; cd05233 743720003003 NAD(P) binding site [chemical binding]; other site 743720003004 active site 743720003005 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 743720003006 DNA photolyase; Region: DNA_photolyase; pfam00875 743720003007 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 743720003008 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 743720003009 DNA binding residues [nucleotide binding] 743720003010 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 743720003011 Protein of unknown function (DUF523); Region: DUF523; cl00733 743720003012 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 743720003013 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 743720003014 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 743720003015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003016 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 743720003017 TIGR01777 family protein; Region: yfcH 743720003018 putative NAD(P) binding site [chemical binding]; other site 743720003019 putative active site [active] 743720003020 ferrochelatase; Reviewed; Region: hemH; PRK00035 743720003021 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 743720003022 C-terminal domain interface [polypeptide binding]; other site 743720003023 active site 743720003024 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 743720003025 active site 743720003026 N-terminal domain interface [polypeptide binding]; other site 743720003027 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 743720003028 uracil-xanthine permease; Region: ncs2; TIGR00801 743720003029 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720003030 active site 743720003031 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720003032 active site 743720003033 putative transporter; Provisional; Region: PRK11660 743720003034 Sulfate transporter family; Region: Sulfate_transp; cl15842 743720003035 Sulfate transporter family; Region: Sulfate_transp; cl15842 743720003036 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 743720003037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 743720003038 Transposase; Region: DEDD_Tnp_IS110; pfam01548 743720003039 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 743720003040 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 743720003041 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 743720003042 TIGR02099 family protein; Region: TIGR02099 743720003043 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 743720003044 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 743720003045 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 743720003046 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 743720003047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 743720003048 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 743720003049 acetyl-CoA synthetase; Provisional; Region: PRK00174 743720003050 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 743720003051 AMP-binding enzyme; Region: AMP-binding; cl15778 743720003052 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720003053 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 743720003054 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 743720003055 active site 743720003056 dimer interface [polypeptide binding]; other site 743720003057 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 743720003058 dimer interface [polypeptide binding]; other site 743720003059 active site 743720003060 Pantoate-beta-alanine ligase; Region: PanC; cd00560 743720003061 pantoate--beta-alanine ligase; Region: panC; TIGR00018 743720003062 active site 743720003063 ATP-binding site [chemical binding]; other site 743720003064 pantoate-binding site; other site 743720003065 HXXH motif; other site 743720003066 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 743720003067 oligomerization interface [polypeptide binding]; other site 743720003068 active site 743720003069 metal binding site [ion binding]; metal-binding site 743720003070 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 743720003071 catalytic center binding site [active] 743720003072 ATP binding site [chemical binding]; other site 743720003073 poly(A) polymerase; Region: pcnB; TIGR01942 743720003074 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 743720003075 active site 743720003076 NTP binding site [chemical binding]; other site 743720003077 metal binding triad [ion binding]; metal-binding site 743720003078 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 743720003079 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 743720003080 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720003081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003082 active site 743720003083 phosphorylation site [posttranslational modification] 743720003084 intermolecular recognition site; other site 743720003085 dimerization interface [polypeptide binding]; other site 743720003086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720003087 Walker A motif; other site 743720003088 ATP binding site [chemical binding]; other site 743720003089 Walker B motif; other site 743720003090 arginine finger; other site 743720003091 Sodium:solute symporter family; Region: SSF; cl00456 743720003092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720003093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720003094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720003095 dimer interface [polypeptide binding]; other site 743720003096 phosphorylation site [posttranslational modification] 743720003097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003098 ATP binding site [chemical binding]; other site 743720003099 Mg2+ binding site [ion binding]; other site 743720003100 G-X-G motif; other site 743720003101 Uncharacterized conserved protein [Function unknown]; Region: COG2308 743720003102 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 743720003103 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 743720003104 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 743720003105 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 743720003106 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 743720003107 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 743720003108 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 743720003109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720003110 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 743720003111 Walker A motif; other site 743720003112 ATP binding site [chemical binding]; other site 743720003113 Walker B motif; other site 743720003114 arginine finger; other site 743720003115 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 743720003116 Integral membrane protein DUF95; Region: DUF95; cl00572 743720003117 RDD family; Region: RDD; cl00746 743720003118 exonuclease I; Provisional; Region: sbcB; PRK11779 743720003119 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 743720003120 active site 743720003121 substrate binding site [chemical binding]; other site 743720003122 catalytic site [active] 743720003123 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 743720003124 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 743720003125 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 743720003126 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 743720003127 putative active site [active] 743720003128 putative substrate binding site [chemical binding]; other site 743720003129 putative cosubstrate binding site; other site 743720003130 catalytic site [active] 743720003131 FOG: CBS domain [General function prediction only]; Region: COG0517 743720003132 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 743720003133 Cache domain; Region: Cache_1; pfam02743 743720003134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720003135 dimerization interface [polypeptide binding]; other site 743720003136 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720003137 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720003138 dimer interface [polypeptide binding]; other site 743720003139 putative CheW interface [polypeptide binding]; other site 743720003140 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 743720003141 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720003142 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 743720003143 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 743720003144 active site 743720003145 catalytic residues [active] 743720003146 Transcriptional regulators [Transcription]; Region: FadR; COG2186 743720003147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720003148 DNA-binding site [nucleotide binding]; DNA binding site 743720003149 FCD domain; Region: FCD; cl11656 743720003150 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 743720003151 EamA-like transporter family; Region: EamA; cl01037 743720003152 DctM-like transporters; Region: DctM; pfam06808 743720003153 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 743720003154 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 743720003155 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720003156 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 743720003157 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 743720003158 Strictosidine synthase; Region: Str_synth; pfam03088 743720003159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003160 active site 743720003161 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 743720003162 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 743720003163 putative active site [active] 743720003164 catalytic residue [active] 743720003165 Helix-turn-helix domains; Region: HTH; cl00088 743720003166 Winged helix-turn helix; Region: HTH_29; pfam13551 743720003167 Helix-turn-helix domains; Region: HTH; cl00088 743720003168 Integrase core domain; Region: rve; cl01316 743720003169 Integrase core domain; Region: rve_3; cl15866 743720003170 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 743720003171 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720003172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 743720003173 NMT1-like family; Region: NMT1_2; cl15260 743720003174 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 743720003175 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 743720003176 putative active site [active] 743720003177 catalytic residue [active] 743720003178 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743720003179 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720003180 DNA binding site [nucleotide binding] 743720003181 domain linker motif; other site 743720003182 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 743720003183 putative dimerization interface [polypeptide binding]; other site 743720003184 putative ligand binding site [chemical binding]; other site 743720003185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720003186 D-galactonate transporter; Region: 2A0114; TIGR00893 743720003187 putative substrate translocation pore; other site 743720003188 galactarate dehydratase; Region: galactar-dH20; TIGR03248 743720003189 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 743720003190 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 743720003191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003192 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720003193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720003194 DNA-binding site [nucleotide binding]; DNA binding site 743720003195 FCD domain; Region: FCD; cl11656 743720003196 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720003197 classical (c) SDRs; Region: SDR_c; cd05233 743720003198 NAD(P) binding site [chemical binding]; other site 743720003199 active site 743720003200 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 743720003201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720003202 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720003203 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 743720003204 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720003205 inhibitor-cofactor binding pocket; inhibition site 743720003206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720003207 catalytic residue [active] 743720003208 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 743720003209 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 743720003210 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 743720003211 Sel1 repeat; Region: Sel1; cl02723 743720003212 Sel1 repeat; Region: Sel1; cl02723 743720003213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003214 FAD dependent oxidoreductase; Region: DAO; pfam01266 743720003215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720003216 non-specific DNA binding site [nucleotide binding]; other site 743720003217 salt bridge; other site 743720003218 sequence-specific DNA binding site [nucleotide binding]; other site 743720003219 Cupin domain; Region: Cupin_2; cl09118 743720003220 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743720003221 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720003222 Yip1 domain; Region: Yip1; cl12048 743720003223 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743720003224 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 743720003225 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 743720003226 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 743720003227 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 743720003228 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 743720003229 D-pathway; other site 743720003230 Putative ubiquinol binding site [chemical binding]; other site 743720003231 Low-spin heme (heme b) binding site [chemical binding]; other site 743720003232 Putative water exit pathway; other site 743720003233 Binuclear center (heme o3/CuB) [ion binding]; other site 743720003234 K-pathway; other site 743720003235 Putative proton exit pathway; other site 743720003236 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 743720003237 Subunit I/III interface [polypeptide binding]; other site 743720003238 Subunit III/IV interface [polypeptide binding]; other site 743720003239 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 743720003240 UbiA prenyltransferase family; Region: UbiA; cl00337 743720003241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 743720003242 outer membrane porin, OprD family; Region: OprD; pfam03573 743720003243 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 743720003244 putative substrate binding pocket [chemical binding]; other site 743720003245 trimer interface [polypeptide binding]; other site 743720003246 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 743720003247 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 743720003248 glycine dehydrogenase; Provisional; Region: PRK05367 743720003249 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 743720003250 tetramer interface [polypeptide binding]; other site 743720003251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720003252 catalytic residue [active] 743720003253 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 743720003254 tetramer interface [polypeptide binding]; other site 743720003255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720003256 catalytic residue [active] 743720003257 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 743720003258 lipoyl attachment site [posttranslational modification]; other site 743720003259 Uncharacterized conserved protein [Function unknown]; Region: COG2912 743720003260 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 743720003261 YebG protein; Region: YebG; cl01217 743720003262 Phosphate-starvation-inducible E; Region: PsiE; cl01264 743720003263 Uncharacterized conserved protein [Function unknown]; Region: COG4715 743720003264 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 743720003265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720003266 ATP binding site [chemical binding]; other site 743720003267 putative Mg++ binding site [ion binding]; other site 743720003268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720003269 nucleotide binding region [chemical binding]; other site 743720003270 ATP-binding site [chemical binding]; other site 743720003271 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720003272 metal binding site [ion binding]; metal-binding site 743720003273 active site 743720003274 I-site; other site 743720003275 short chain dehydrogenase; Provisional; Region: PRK05693 743720003276 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 743720003277 NADP binding site [chemical binding]; other site 743720003278 active site 743720003279 steroid binding site; other site 743720003280 Protein of unknown function (DUF328); Region: DUF328; cl01143 743720003281 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 743720003282 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 743720003283 putative active site [active] 743720003284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720003285 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 743720003286 trimer interface [polypeptide binding]; other site 743720003287 dimer interface [polypeptide binding]; other site 743720003288 putative active site [active] 743720003289 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 743720003290 MoaE interaction surface [polypeptide binding]; other site 743720003291 MoeB interaction surface [polypeptide binding]; other site 743720003292 thiocarboxylated glycine; other site 743720003293 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 743720003294 MoaE homodimer interface [polypeptide binding]; other site 743720003295 MoaD interaction [polypeptide binding]; other site 743720003296 active site residues [active] 743720003297 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 743720003298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003299 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720003300 Domain of unknown function DUF21; Region: DUF21; pfam01595 743720003301 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 743720003302 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 743720003303 Transporter associated domain; Region: CorC_HlyC; cl08393 743720003304 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 743720003305 signal recognition particle protein; Provisional; Region: PRK10867 743720003306 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 743720003307 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 743720003308 P loop; other site 743720003309 GTP binding site [chemical binding]; other site 743720003310 Signal peptide binding domain; Region: SRP_SPB; pfam02978 743720003311 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 743720003312 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 743720003313 RimM N-terminal domain; Region: RimM; pfam01782 743720003314 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 743720003315 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 743720003316 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 743720003317 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 743720003318 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 743720003319 Int/Topo IB signature motif; other site 743720003320 active site 743720003321 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 743720003322 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 743720003323 dimerization domain [polypeptide binding]; other site 743720003324 dimer interface [polypeptide binding]; other site 743720003325 catalytic residues [active] 743720003326 homoserine dehydrogenase; Provisional; Region: PRK06349 743720003327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003328 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 743720003329 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 743720003330 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 743720003331 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 743720003332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720003333 catalytic residue [active] 743720003334 Endonuclease I; Region: Endonuclease_1; cl01003 743720003335 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 743720003336 PspA/IM30 family; Region: PspA_IM30; pfam04012 743720003337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 743720003338 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 743720003339 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720003340 ATPase involved in DNA repair; Region: DUF3686; pfam12458 743720003341 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 743720003342 linker region; other site 743720003343 AAA domain; Region: AAA_22; pfam13401 743720003344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720003345 Walker A motif; other site 743720003346 ATP binding site [chemical binding]; other site 743720003347 Walker B motif; other site 743720003348 Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171 743720003349 PLD-like domain; Region: PLDc_2; pfam13091 743720003350 putative active site [active] 743720003351 catalytic site [active] 743720003352 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 743720003353 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743720003354 ATP binding site [chemical binding]; other site 743720003355 Mg++ binding site [ion binding]; other site 743720003356 motif III; other site 743720003357 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720003358 nucleotide binding region [chemical binding]; other site 743720003359 ATP-binding site [chemical binding]; other site 743720003360 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 743720003361 active site 743720003362 dimer interface [polypeptide binding]; other site 743720003363 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720003364 ligand binding site [chemical binding]; other site 743720003365 flexible hinge region; other site 743720003366 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720003367 metal binding site [ion binding]; metal-binding site 743720003368 active site 743720003369 I-site; other site 743720003370 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720003371 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 743720003372 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 743720003373 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720003374 substrate binding pocket [chemical binding]; other site 743720003375 membrane-bound complex binding site; other site 743720003376 hinge residues; other site 743720003377 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 743720003378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743720003379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743720003380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720003381 dimer interface [polypeptide binding]; other site 743720003382 conserved gate region; other site 743720003383 putative PBP binding loops; other site 743720003384 ABC-ATPase subunit interface; other site 743720003385 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 743720003386 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 743720003387 Walker A/P-loop; other site 743720003388 ATP binding site [chemical binding]; other site 743720003389 Q-loop/lid; other site 743720003390 ABC transporter signature motif; other site 743720003391 Walker B; other site 743720003392 D-loop; other site 743720003393 H-loop/switch region; other site 743720003394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003395 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 743720003396 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 743720003397 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720003398 tetrameric interface [polypeptide binding]; other site 743720003399 NAD binding site [chemical binding]; other site 743720003400 catalytic residues [active] 743720003401 shikimate transporter; Provisional; Region: PRK09952 743720003402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720003403 putative substrate translocation pore; other site 743720003404 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720003405 Helix-turn-helix domains; Region: HTH; cl00088 743720003406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720003407 dimerization interface [polypeptide binding]; other site 743720003408 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 743720003409 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 743720003410 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 743720003411 GIY-YIG motif/motif A; other site 743720003412 putative active site [active] 743720003413 putative metal binding site [ion binding]; other site 743720003414 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720003415 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 743720003416 C-terminal domain interface [polypeptide binding]; other site 743720003417 GSH binding site (G-site) [chemical binding]; other site 743720003418 dimer interface [polypeptide binding]; other site 743720003419 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 743720003420 N-terminal domain interface [polypeptide binding]; other site 743720003421 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 743720003422 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 743720003423 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 743720003424 ethanolamine permease; Region: 2A0305; TIGR00908 743720003425 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 743720003426 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720003427 NAD(P) binding site [chemical binding]; other site 743720003428 catalytic residues [active] 743720003429 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 743720003430 Helix-turn-helix domain; Region: HTH_18; pfam12833 743720003431 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720003432 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720003433 Helix-turn-helix domains; Region: HTH; cl00088 743720003434 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 743720003435 dimerization interface [polypeptide binding]; other site 743720003436 substrate binding pocket [chemical binding]; other site 743720003437 Helix-turn-helix domains; Region: HTH; cl00088 743720003438 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 743720003439 Cupin domain; Region: Cupin_2; cl09118 743720003440 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720003441 2-isopropylmalate synthase; Validated; Region: PRK03739 743720003442 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 743720003443 active site 743720003444 catalytic residues [active] 743720003445 metal binding site [ion binding]; metal-binding site 743720003446 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 743720003447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720003448 Helix-turn-helix domains; Region: HTH; cl00088 743720003449 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 743720003450 substrate binding pocket [chemical binding]; other site 743720003451 dimerization interface [polypeptide binding]; other site 743720003452 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 743720003453 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 743720003454 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 743720003455 FAD binding domain; Region: FAD_binding_4; pfam01565 743720003456 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 743720003457 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720003458 ATP binding site [chemical binding]; other site 743720003459 Walker B motif; other site 743720003460 Helix-turn-helix domains; Region: HTH; cl00088 743720003461 transcriptional activator TtdR; Provisional; Region: PRK09801 743720003462 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720003463 dimerization interface [polypeptide binding]; other site 743720003464 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 743720003465 Helix-turn-helix domains; Region: HTH; cl00088 743720003466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720003467 dimerization interface [polypeptide binding]; other site 743720003468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720003469 D-galactonate transporter; Region: 2A0114; TIGR00893 743720003470 putative substrate translocation pore; other site 743720003471 SAF domain; Region: SAF; cl00555 743720003472 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 743720003473 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 743720003474 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720003475 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 743720003476 tetramerization interface [polypeptide binding]; other site 743720003477 NAD(P) binding site [chemical binding]; other site 743720003478 catalytic residues [active] 743720003479 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 743720003480 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 743720003481 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 743720003482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003483 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 743720003484 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720003485 inhibitor-cofactor binding pocket; inhibition site 743720003486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720003487 catalytic residue [active] 743720003488 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720003489 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 743720003490 tetramerization interface [polypeptide binding]; other site 743720003491 NAD(P) binding site [chemical binding]; other site 743720003492 catalytic residues [active] 743720003493 outer membrane porin, OprD family; Region: OprD; pfam03573 743720003494 GAF domain; Region: GAF_2; pfam13185 743720003495 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 743720003496 Helix-turn-helix domains; Region: HTH; cl00088 743720003497 Amino acid synthesis; Region: AA_synth; pfam06684 743720003498 Flavin Reductases; Region: FlaRed; cl00801 743720003499 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720003500 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 743720003501 NAD(P) binding site [chemical binding]; other site 743720003502 catalytic residues [active] 743720003503 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 743720003504 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 743720003505 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 743720003506 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720003507 NIPSNAP; Region: NIPSNAP; pfam07978 743720003508 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 743720003509 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 743720003510 Walker A/P-loop; other site 743720003511 ATP binding site [chemical binding]; other site 743720003512 Q-loop/lid; other site 743720003513 ABC transporter signature motif; other site 743720003514 Walker B; other site 743720003515 D-loop; other site 743720003516 H-loop/switch region; other site 743720003517 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 743720003518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720003519 dimer interface [polypeptide binding]; other site 743720003520 conserved gate region; other site 743720003521 ABC-ATPase subunit interface; other site 743720003522 NMT1-like family; Region: NMT1_2; cl15260 743720003523 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 743720003524 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 743720003525 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 743720003526 active site 743720003527 catalytic residues [active] 743720003528 transcriptional activator TtdR; Provisional; Region: PRK09801 743720003529 Helix-turn-helix domains; Region: HTH; cl00088 743720003530 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 743720003531 putative effector binding pocket; other site 743720003532 putative dimerization interface [polypeptide binding]; other site 743720003533 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 743720003534 substrate binding site [chemical binding]; other site 743720003535 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 743720003536 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 743720003537 substrate binding site [chemical binding]; other site 743720003538 ligand binding site [chemical binding]; other site 743720003539 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 743720003540 short chain dehydrogenase; Provisional; Region: PRK06924 743720003541 NADP binding site [chemical binding]; other site 743720003542 homodimer interface [polypeptide binding]; other site 743720003543 active site 743720003544 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 743720003545 catalytic residues [active] 743720003546 Nucleoid-associated protein [General function prediction only]; Region: COG3081 743720003547 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 743720003548 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 743720003549 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 743720003550 putative active site [active] 743720003551 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 743720003552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720003553 TPR motif; other site 743720003554 binding surface 743720003555 putative transporter; Provisional; Region: PRK11021 743720003556 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720003557 putative DNA binding site [nucleotide binding]; other site 743720003558 putative Zn2+ binding site [ion binding]; other site 743720003559 Helix-turn-helix domains; Region: HTH; cl00088 743720003560 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 743720003561 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720003562 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 743720003563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720003564 S-adenosylmethionine binding site [chemical binding]; other site 743720003565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720003566 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720003567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720003568 dimer interface [polypeptide binding]; other site 743720003569 phosphorylation site [posttranslational modification] 743720003570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003571 ATP binding site [chemical binding]; other site 743720003572 Mg2+ binding site [ion binding]; other site 743720003573 G-X-G motif; other site 743720003574 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720003575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003576 active site 743720003577 phosphorylation site [posttranslational modification] 743720003578 intermolecular recognition site; other site 743720003579 dimerization interface [polypeptide binding]; other site 743720003580 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720003581 DNA binding site [nucleotide binding] 743720003582 Sulfatase; Region: Sulfatase; cl10460 743720003583 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 743720003584 active site 743720003585 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 743720003586 active site 743720003587 catalytic residues [active] 743720003588 Chromate transporter; Region: Chromate_transp; pfam02417 743720003589 Chromate transporter; Region: Chromate_transp; pfam02417 743720003590 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 743720003591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720003592 motif II; other site 743720003593 L-type amino acid transporter; Region: 2A0308; TIGR00911 743720003594 Methyltransferase domain; Region: Methyltransf_31; pfam13847 743720003595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720003596 S-adenosylmethionine binding site [chemical binding]; other site 743720003597 exonuclease subunit SbcD; Provisional; Region: PRK10966 743720003598 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 743720003599 active site 743720003600 metal binding site [ion binding]; metal-binding site 743720003601 DNA binding site [nucleotide binding] 743720003602 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 743720003603 Cache domain; Region: Cache_2; cl07034 743720003604 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 743720003605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720003606 dimerization interface [polypeptide binding]; other site 743720003607 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720003608 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720003609 dimer interface [polypeptide binding]; other site 743720003610 putative CheW interface [polypeptide binding]; other site 743720003611 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 743720003612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720003613 DNA-binding site [nucleotide binding]; DNA binding site 743720003614 UTRA domain; Region: UTRA; cl01230 743720003615 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 743720003616 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743720003617 active site 743720003618 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 743720003619 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 743720003620 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 743720003621 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 743720003622 exonuclease subunit SbcC; Provisional; Region: PRK10246 743720003623 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720003624 Walker A/P-loop; other site 743720003625 ATP binding site [chemical binding]; other site 743720003626 Q-loop/lid; other site 743720003627 exonuclease subunit SbcC; Provisional; Region: PRK10246 743720003628 exonuclease subunit SbcC; Provisional; Region: PRK10246 743720003629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720003630 ABC transporter signature motif; other site 743720003631 Walker B; other site 743720003632 D-loop; other site 743720003633 H-loop/switch region; other site 743720003634 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 743720003635 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 743720003636 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 743720003637 YaeQ protein; Region: YaeQ; cl01913 743720003638 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 743720003639 DHH family; Region: DHH; pfam01368 743720003640 DHHA1 domain; Region: DHHA1; pfam02272 743720003641 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 743720003642 putative metal binding site [ion binding]; other site 743720003643 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720003644 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720003645 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720003646 dimerization interface [polypeptide binding]; other site 743720003647 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720003648 dimer interface [polypeptide binding]; other site 743720003649 putative CheW interface [polypeptide binding]; other site 743720003650 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 743720003651 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 743720003652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003653 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 743720003654 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720003655 putative binding surface; other site 743720003656 active site 743720003657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720003658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003659 ATP binding site [chemical binding]; other site 743720003660 Mg2+ binding site [ion binding]; other site 743720003661 G-X-G motif; other site 743720003662 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 743720003663 Response regulator receiver domain; Region: Response_reg; pfam00072 743720003664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003665 active site 743720003666 phosphorylation site [posttranslational modification] 743720003667 intermolecular recognition site; other site 743720003668 dimerization interface [polypeptide binding]; other site 743720003669 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 743720003670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 743720003671 active site 743720003672 phosphorylation site [posttranslational modification] 743720003673 intermolecular recognition site; other site 743720003674 dimerization interface [polypeptide binding]; other site 743720003675 CheB methylesterase; Region: CheB_methylest; pfam01339 743720003676 Response regulator receiver domain; Region: Response_reg; pfam00072 743720003677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003678 active site 743720003679 phosphorylation site [posttranslational modification] 743720003680 intermolecular recognition site; other site 743720003681 dimerization interface [polypeptide binding]; other site 743720003682 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720003683 metal binding site [ion binding]; metal-binding site 743720003684 active site 743720003685 I-site; other site 743720003686 Cache domain; Region: Cache_1; pfam02743 743720003687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720003688 dimerization interface [polypeptide binding]; other site 743720003689 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720003690 metal binding site [ion binding]; metal-binding site 743720003691 active site 743720003692 I-site; other site 743720003693 peptide chain release factor 2; Validated; Region: prfB; PRK00578 743720003694 RF-1 domain; Region: RF-1; cl02875 743720003695 RF-1 domain; Region: RF-1; cl02875 743720003696 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 743720003697 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 743720003698 dimer interface [polypeptide binding]; other site 743720003699 putative anticodon binding site; other site 743720003700 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 743720003701 motif 1; other site 743720003702 active site 743720003703 motif 2; other site 743720003704 motif 3; other site 743720003705 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 743720003706 conserved hypothetical protein; Region: QEGLA; TIGR02421 743720003707 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 743720003708 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720003709 ligand binding site [chemical binding]; other site 743720003710 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 743720003711 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 743720003712 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 743720003713 adenylate kinase; Reviewed; Region: adk; PRK00279 743720003714 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 743720003715 AMP-binding site [chemical binding]; other site 743720003716 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 743720003717 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 743720003718 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 743720003719 Protein of unknown function DUF72; Region: DUF72; cl00777 743720003720 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 743720003721 Imelysin; Region: Peptidase_M75; cl09159 743720003722 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 743720003723 Imelysin; Region: Peptidase_M75; cl09159 743720003724 biofilm formation regulator HmsP; Provisional; Region: PRK11829 743720003725 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720003726 metal binding site [ion binding]; metal-binding site 743720003727 active site 743720003728 I-site; other site 743720003729 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720003730 superoxide dismutase; Provisional; Region: PRK10543 743720003731 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 743720003732 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 743720003733 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 743720003734 EamA-like transporter family; Region: EamA; cl01037 743720003735 LysE type translocator; Region: LysE; cl00565 743720003736 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 743720003737 Helix-turn-helix domains; Region: HTH; cl00088 743720003738 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720003739 dimerization interface [polypeptide binding]; other site 743720003740 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743720003741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003742 NAD(P) binding site [chemical binding]; other site 743720003743 active site 743720003744 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 743720003745 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 743720003746 FMN binding site [chemical binding]; other site 743720003747 active site 743720003748 substrate binding site [chemical binding]; other site 743720003749 catalytic residue [active] 743720003750 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720003751 dimerization interface [polypeptide binding]; other site 743720003752 putative DNA binding site [nucleotide binding]; other site 743720003753 putative Zn2+ binding site [ion binding]; other site 743720003754 Protein of unknown function, DUF479; Region: DUF479; cl01203 743720003755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720003756 DNA-binding site [nucleotide binding]; DNA binding site 743720003757 Transcriptional regulators [Transcription]; Region: FadR; COG2186 743720003758 Helix-turn-helix domains; Region: HTH; cl00088 743720003759 FCD domain; Region: FCD; cl11656 743720003760 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 743720003761 Putative ammonia monooxygenase; Region: AmoA; pfam05145 743720003762 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 743720003763 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743720003764 putative acyl-acceptor binding pocket; other site 743720003765 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720003766 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 743720003767 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 743720003768 putative active site [active] 743720003769 catalytic site [active] 743720003770 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 743720003771 PLD-like domain; Region: PLDc_2; pfam13091 743720003772 putative active site [active] 743720003773 catalytic site [active] 743720003774 GAF domain; Region: GAF; cl15785 743720003775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720003776 dimer interface [polypeptide binding]; other site 743720003777 phosphorylation site [posttranslational modification] 743720003778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003779 ATP binding site [chemical binding]; other site 743720003780 Mg2+ binding site [ion binding]; other site 743720003781 G-X-G motif; other site 743720003782 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 743720003783 PAS fold; Region: PAS_4; pfam08448 743720003784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720003785 PAS fold; Region: PAS_3; pfam08447 743720003786 putative active site [active] 743720003787 heme pocket [chemical binding]; other site 743720003788 PAS domain S-box; Region: sensory_box; TIGR00229 743720003789 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720003790 putative active site [active] 743720003791 heme pocket [chemical binding]; other site 743720003792 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720003793 PAS domain S-box; Region: sensory_box; TIGR00229 743720003794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 743720003795 dimer interface [polypeptide binding]; other site 743720003796 phosphorylation site [posttranslational modification] 743720003797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003798 ATP binding site [chemical binding]; other site 743720003799 Mg2+ binding site [ion binding]; other site 743720003800 G-X-G motif; other site 743720003801 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720003802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003803 active site 743720003804 phosphorylation site [posttranslational modification] 743720003805 intermolecular recognition site; other site 743720003806 dimerization interface [polypeptide binding]; other site 743720003807 histidine kinase; Provisional; Region: PRK13557 743720003808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720003809 putative active site [active] 743720003810 heme pocket [chemical binding]; other site 743720003811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720003812 dimer interface [polypeptide binding]; other site 743720003813 phosphorylation site [posttranslational modification] 743720003814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003815 ATP binding site [chemical binding]; other site 743720003816 Mg2+ binding site [ion binding]; other site 743720003817 G-X-G motif; other site 743720003818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003819 active site 743720003820 phosphorylation site [posttranslational modification] 743720003821 intermolecular recognition site; other site 743720003822 dimerization interface [polypeptide binding]; other site 743720003823 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743720003824 active site 743720003825 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 743720003826 phosphate binding site [ion binding]; other site 743720003827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339; cl15420 743720003828 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 743720003829 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 743720003830 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720003831 N-terminal plug; other site 743720003832 ligand-binding site [chemical binding]; other site 743720003833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720003834 Coenzyme A binding pocket [chemical binding]; other site 743720003835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720003836 putative substrate translocation pore; other site 743720003837 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 743720003838 Cache domain; Region: Cache_1; pfam02743 743720003839 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720003840 metal binding site [ion binding]; metal-binding site 743720003841 active site 743720003842 I-site; other site 743720003843 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720003844 Helix-turn-helix domains; Region: HTH; cl00088 743720003845 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720003846 dimerization interface [polypeptide binding]; other site 743720003847 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720003848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003849 NAD(P) binding site [chemical binding]; other site 743720003850 active site 743720003851 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720003852 classical (c) SDRs; Region: SDR_c; cd05233 743720003853 NAD(P) binding site [chemical binding]; other site 743720003854 active site 743720003855 aminotransferase; Validated; Region: PRK07046 743720003856 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720003857 inhibitor-cofactor binding pocket; inhibition site 743720003858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720003859 catalytic residue [active] 743720003860 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743720003861 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720003862 amidase; Validated; Region: PRK06565 743720003863 Amidase; Region: Amidase; cl11426 743720003864 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 743720003865 OsmC-like protein; Region: OsmC; cl00767 743720003866 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 743720003867 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 743720003868 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 743720003869 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720003870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720003871 Integral membrane protein TerC family; Region: TerC; cl10468 743720003872 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720003873 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 743720003874 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 743720003875 dimer interface [polypeptide binding]; other site 743720003876 ADP-ribose binding site [chemical binding]; other site 743720003877 active site 743720003878 nudix motif; other site 743720003879 metal binding site [ion binding]; metal-binding site 743720003880 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720003881 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 743720003882 conserved cys residue [active] 743720003883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720003884 Helix-turn-helix domains; Region: HTH; cl00088 743720003885 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 743720003886 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 743720003887 substrate binding pocket [chemical binding]; other site 743720003888 dimerization interface [polypeptide binding]; other site 743720003889 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 743720003890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003891 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 743720003892 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720003893 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 743720003894 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 743720003895 active site 743720003896 catalytic site [active] 743720003897 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 743720003898 CoA-transferase family III; Region: CoA_transf_3; pfam02515 743720003899 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 743720003900 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 743720003901 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 743720003902 shikimate binding site; other site 743720003903 NAD(P) binding site [chemical binding]; other site 743720003904 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 743720003905 trimer interface [polypeptide binding]; other site 743720003906 active site 743720003907 dimer interface [polypeptide binding]; other site 743720003908 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720003909 Helix-turn-helix domains; Region: HTH; cl00088 743720003910 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 743720003911 putative effector binding pocket; other site 743720003912 putative dimerization interface [polypeptide binding]; other site 743720003913 acetylornithine aminotransferase; Provisional; Region: PRK02627 743720003914 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720003915 inhibitor-cofactor binding pocket; inhibition site 743720003916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720003917 catalytic residue [active] 743720003918 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 743720003919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720003920 Helix-turn-helix domains; Region: HTH; cl00088 743720003921 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 743720003922 putative dimerization interface [polypeptide binding]; other site 743720003923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720003924 D-galactonate transporter; Region: 2A0114; TIGR00893 743720003925 putative substrate translocation pore; other site 743720003926 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743720003927 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720003928 DNA binding site [nucleotide binding] 743720003929 domain linker motif; other site 743720003930 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 743720003931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720003932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003933 active site 743720003934 phosphorylation site [posttranslational modification] 743720003935 intermolecular recognition site; other site 743720003936 dimerization interface [polypeptide binding]; other site 743720003937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720003938 DNA binding site [nucleotide binding] 743720003939 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 743720003940 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 743720003941 catalytic residues [active] 743720003942 catalytic nucleophile [active] 743720003943 Presynaptic Site I dimer interface [polypeptide binding]; other site 743720003944 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 743720003945 Synaptic Flat tetramer interface [polypeptide binding]; other site 743720003946 Synaptic Site I dimer interface [polypeptide binding]; other site 743720003947 DNA binding site [nucleotide binding] 743720003948 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 743720003949 DNA-binding interface [nucleotide binding]; DNA binding site 743720003950 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 743720003951 active site residue [active] 743720003952 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 743720003953 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 743720003954 conserved cys residue [active] 743720003955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720003956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720003957 putative acetyltransferase; Provisional; Region: PRK03624 743720003958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720003959 Coenzyme A binding pocket [chemical binding]; other site 743720003960 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 743720003961 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720003962 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 743720003963 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720003964 Walker A/P-loop; other site 743720003965 ATP binding site [chemical binding]; other site 743720003966 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 743720003967 putative active site [active] 743720003968 putative metal-binding site [ion binding]; other site 743720003969 GAF domain; Region: GAF_2; pfam13185 743720003970 GAF domain; Region: GAF; cl15785 743720003971 putative diguanylate cyclase; Provisional; Region: PRK09776 743720003972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720003973 dimer interface [polypeptide binding]; other site 743720003974 phosphorylation site [posttranslational modification] 743720003975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003976 ATP binding site [chemical binding]; other site 743720003977 Mg2+ binding site [ion binding]; other site 743720003978 G-X-G motif; other site 743720003979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003980 Response regulator receiver domain; Region: Response_reg; pfam00072 743720003981 active site 743720003982 phosphorylation site [posttranslational modification] 743720003983 intermolecular recognition site; other site 743720003984 dimerization interface [polypeptide binding]; other site 743720003985 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 743720003986 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 743720003987 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 743720003988 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720003989 Helix-turn-helix domains; Region: HTH; cl00088 743720003990 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720003991 dimerization interface [polypeptide binding]; other site 743720003992 putative transcriptional regulator; Provisional; Region: PRK11640 743720003993 Helix-turn-helix domains; Region: HTH; cl00088 743720003994 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 743720003995 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 743720003996 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 743720003997 putative NAD(P) binding site [chemical binding]; other site 743720003998 putative active site [active] 743720003999 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720004000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720004001 dimerization interface [polypeptide binding]; other site 743720004002 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720004003 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720004004 dimer interface [polypeptide binding]; other site 743720004005 putative CheW interface [polypeptide binding]; other site 743720004006 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 743720004007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720004008 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 743720004009 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720004010 dimerization interface [polypeptide binding]; other site 743720004011 putative DNA binding site [nucleotide binding]; other site 743720004012 putative Zn2+ binding site [ion binding]; other site 743720004013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720004014 dimerization interface [polypeptide binding]; other site 743720004015 putative DNA binding site [nucleotide binding]; other site 743720004016 putative Zn2+ binding site [ion binding]; other site 743720004017 Low molecular weight phosphatase family; Region: LMWPc; cd00115 743720004018 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 743720004019 active site 743720004020 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 743720004021 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 743720004022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720004023 Coenzyme A binding pocket [chemical binding]; other site 743720004024 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 743720004025 arsenical pump membrane protein; Provisional; Region: PRK15445 743720004026 transmembrane helices; other site 743720004027 GAF domain; Region: GAF_2; pfam13185 743720004028 GAF domain; Region: GAF; cl15785 743720004029 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 743720004030 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720004031 FecR protein; Region: FecR; pfam04773 743720004032 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720004033 ligand binding site [chemical binding]; other site 743720004034 CHASE2 domain; Region: CHASE2; cl01732 743720004035 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 743720004036 cyclase homology domain; Region: CHD; cd07302 743720004037 nucleotidyl binding site; other site 743720004038 metal binding site [ion binding]; metal-binding site 743720004039 dimer interface [polypeptide binding]; other site 743720004040 Transcriptional regulators [Transcription]; Region: MarR; COG1846 743720004041 Helix-turn-helix domains; Region: HTH; cl00088 743720004042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 743720004043 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 743720004044 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 743720004045 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720004046 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720004047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720004048 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 743720004049 classical (c) SDRs; Region: SDR_c; cd05233 743720004050 NAD(P) binding site [chemical binding]; other site 743720004051 active site 743720004052 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720004053 Helix-turn-helix domains; Region: HTH; cl00088 743720004054 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720004055 dimerization interface [polypeptide binding]; other site 743720004056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720004057 FAD dependent oxidoreductase; Region: DAO; pfam01266 743720004058 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720004059 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 743720004060 tetrameric interface [polypeptide binding]; other site 743720004061 NAD binding site [chemical binding]; other site 743720004062 catalytic residues [active] 743720004063 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720004064 Helix-turn-helix domains; Region: HTH; cl00088 743720004065 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 743720004066 dimerization interface [polypeptide binding]; other site 743720004067 substrate binding pocket [chemical binding]; other site 743720004068 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 743720004069 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720004070 inhibitor-cofactor binding pocket; inhibition site 743720004071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720004072 catalytic residue [active] 743720004073 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 743720004074 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 743720004075 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720004076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720004077 Coenzyme A binding pocket [chemical binding]; other site 743720004078 Phosphate transporter family; Region: PHO4; cl00396 743720004079 Phosphate transporter family; Region: PHO4; cl00396 743720004080 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 743720004081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720004082 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720004083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720004084 dimer interface [polypeptide binding]; other site 743720004085 phosphorylation site [posttranslational modification] 743720004086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720004087 ATP binding site [chemical binding]; other site 743720004088 Mg2+ binding site [ion binding]; other site 743720004089 G-X-G motif; other site 743720004090 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 743720004091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720004092 active site 743720004093 phosphorylation site [posttranslational modification] 743720004094 intermolecular recognition site; other site 743720004095 dimerization interface [polypeptide binding]; other site 743720004096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720004097 DNA binding site [nucleotide binding] 743720004098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 743720004099 TPR motif; other site 743720004100 binding surface 743720004101 short chain dehydrogenase; Provisional; Region: PRK09072 743720004102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720004103 NAD(P) binding site [chemical binding]; other site 743720004104 active site 743720004105 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 743720004106 heme binding pocket [chemical binding]; other site 743720004107 heme ligand [chemical binding]; other site 743720004108 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 743720004109 AMP-binding enzyme; Region: AMP-binding; cl15778 743720004110 Thermostable hemolysin; Region: T_hemolysin; pfam12261 743720004111 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 743720004112 Helix-turn-helix domains; Region: HTH; cl00088 743720004113 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720004114 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 743720004115 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 743720004116 Cation efflux family; Region: Cation_efflux; cl00316 743720004117 Transcriptional regulator [Transcription]; Region: IclR; COG1414 743720004118 Helix-turn-helix domains; Region: HTH; cl00088 743720004119 Bacterial transcriptional regulator; Region: IclR; pfam01614 743720004120 enoyl-CoA hydratase; Provisional; Region: PRK06688 743720004121 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720004122 substrate binding site [chemical binding]; other site 743720004123 oxyanion hole (OAH) forming residues; other site 743720004124 trimer interface [polypeptide binding]; other site 743720004125 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 743720004126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720004127 CoA-ligase; Region: Ligase_CoA; cl02894 743720004128 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720004129 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 743720004130 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 743720004131 Walker A/P-loop; other site 743720004132 ATP binding site [chemical binding]; other site 743720004133 Q-loop/lid; other site 743720004134 ABC transporter signature motif; other site 743720004135 Walker B; other site 743720004136 D-loop; other site 743720004137 H-loop/switch region; other site 743720004138 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 743720004139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720004140 dimer interface [polypeptide binding]; other site 743720004141 conserved gate region; other site 743720004142 putative PBP binding loops; other site 743720004143 ABC-ATPase subunit interface; other site 743720004144 NMT1/THI5 like; Region: NMT1; pfam09084 743720004145 NMT1-like family; Region: NMT1_2; cl15260 743720004146 outer membrane porin, OprD family; Region: OprD; pfam03573 743720004147 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720004148 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 743720004149 substrate binding site [chemical binding]; other site 743720004150 oxyanion hole (OAH) forming residues; other site 743720004151 trimer interface [polypeptide binding]; other site 743720004152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720004153 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 743720004154 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 743720004155 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 743720004156 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720004157 dimer interface [polypeptide binding]; other site 743720004158 active site 743720004159 Cupin domain; Region: Cupin_2; cl09118 743720004160 Helix-turn-helix domain; Region: HTH_18; pfam12833 743720004161 Cupin domain; Region: Cupin_2; cl09118 743720004162 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 743720004163 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720004164 Cupin domain; Region: Cupin_2; cl09118 743720004165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720004166 FAD dependent oxidoreductase; Region: DAO; pfam01266 743720004167 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 743720004168 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720004169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720004170 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 743720004171 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 743720004172 THF binding site; other site 743720004173 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 743720004174 substrate binding site [chemical binding]; other site 743720004175 THF binding site; other site 743720004176 zinc-binding site [ion binding]; other site 743720004177 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 743720004178 catalytic triad [active] 743720004179 conserved cis-peptide bond; other site 743720004180 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720004181 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 743720004182 conserved cys residue [active] 743720004183 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 743720004184 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 743720004185 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720004186 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720004187 DNA binding residues [nucleotide binding] 743720004188 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 743720004189 FecR protein; Region: FecR; pfam04773 743720004190 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743720004191 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720004192 N-terminal plug; other site 743720004193 ligand-binding site [chemical binding]; other site 743720004194 putative fumarate hydratase; Provisional; Region: PRK15392 743720004195 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 743720004196 Fumarase C-terminus; Region: Fumerase_C; cl00795 743720004197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720004198 metal binding site [ion binding]; metal-binding site 743720004199 active site 743720004200 I-site; other site 743720004201 hypothetical protein; Provisional; Region: PRK05713 743720004202 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720004203 catalytic loop [active] 743720004204 iron binding site [ion binding]; other site 743720004205 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 743720004206 FAD binding pocket [chemical binding]; other site 743720004207 FAD binding motif [chemical binding]; other site 743720004208 phosphate binding motif [ion binding]; other site 743720004209 beta-alpha-beta structure motif; other site 743720004210 NAD binding pocket [chemical binding]; other site 743720004211 pyruvate kinase; Provisional; Region: PRK05826 743720004212 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 743720004213 domain interfaces; other site 743720004214 active site 743720004215 universal stress protein UspE; Provisional; Region: PRK11175 743720004216 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720004217 Ligand Binding Site [chemical binding]; other site 743720004218 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720004219 Ligand Binding Site [chemical binding]; other site 743720004220 Tetratricopeptide repeat; Region: TPR_16; pfam13432 743720004221 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720004222 PilZ domain; Region: PilZ; cl01260 743720004223 Ferredoxin [Energy production and conversion]; Region: COG1146 743720004224 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 743720004225 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 743720004226 MutS domain I; Region: MutS_I; pfam01624 743720004227 MutS domain II; Region: MutS_II; pfam05188 743720004228 MutS family domain IV; Region: MutS_IV; pfam05190 743720004229 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 743720004230 Walker A/P-loop; other site 743720004231 ATP binding site [chemical binding]; other site 743720004232 Q-loop/lid; other site 743720004233 ABC transporter signature motif; other site 743720004234 Walker B; other site 743720004235 D-loop; other site 743720004236 H-loop/switch region; other site 743720004237 Competence-damaged protein; Region: CinA; cl00666 743720004238 recombinase A; Provisional; Region: recA; PRK09354 743720004239 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 743720004240 hexamer interface [polypeptide binding]; other site 743720004241 Walker A motif; other site 743720004242 ATP binding site [chemical binding]; other site 743720004243 Walker B motif; other site 743720004244 RecX family; Region: RecX; cl00936 743720004245 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 743720004246 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 743720004247 DTW domain; Region: DTW; cl01221 743720004248 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720004249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720004250 active site 743720004251 phosphorylation site [posttranslational modification] 743720004252 intermolecular recognition site; other site 743720004253 dimerization interface [polypeptide binding]; other site 743720004254 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720004255 DNA binding residues [nucleotide binding] 743720004256 dimerization interface [polypeptide binding]; other site 743720004257 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 743720004258 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 743720004259 Helix-turn-helix domains; Region: HTH; cl00088 743720004260 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 743720004261 putative dimerization interface [polypeptide binding]; other site 743720004262 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 743720004263 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 743720004264 FAD binding pocket [chemical binding]; other site 743720004265 FAD binding motif [chemical binding]; other site 743720004266 phosphate binding motif [ion binding]; other site 743720004267 beta-alpha-beta structure motif; other site 743720004268 NAD binding pocket [chemical binding]; other site 743720004269 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 743720004270 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 743720004271 heme binding site [chemical binding]; other site 743720004272 ferroxidase pore; other site 743720004273 ferroxidase diiron center [ion binding]; other site 743720004274 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 743720004275 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 743720004276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720004277 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 743720004278 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 743720004279 dimer interface [polypeptide binding]; other site 743720004280 putative active site [active] 743720004281 putative substrate binding site [chemical binding]; other site 743720004282 catalytic site [active] 743720004283 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 743720004284 active site 743720004285 substrate binding pocket [chemical binding]; other site 743720004286 dimer interface [polypeptide binding]; other site 743720004287 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720004288 ligand binding site [chemical binding]; other site 743720004289 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 743720004290 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 743720004291 ANP binding site [chemical binding]; other site 743720004292 Substrate Binding Site II [chemical binding]; other site 743720004293 Substrate Binding Site I [chemical binding]; other site 743720004294 HopJ type III effector protein; Region: HopJ; pfam08888 743720004295 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 743720004296 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 743720004297 homooctamer interface [polypeptide binding]; other site 743720004298 active site 743720004299 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 743720004300 homodecamer interface [polypeptide binding]; other site 743720004301 GTP cyclohydrolase I; Provisional; Region: PLN03044 743720004302 active site 743720004303 putative catalytic site residues [active] 743720004304 zinc binding site [ion binding]; other site 743720004305 GTP-CH-I/GFRP interaction surface; other site 743720004306 dihydromonapterin reductase; Provisional; Region: PRK06483 743720004307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720004308 NAD(P) binding site [chemical binding]; other site 743720004309 active site 743720004310 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 743720004311 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 743720004312 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 743720004313 DNA binding residues [nucleotide binding] 743720004314 B12 binding domain; Region: B12-binding_2; cl03653 743720004315 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720004316 PAS domain; Region: PAS_9; pfam13426 743720004317 putative active site [active] 743720004318 heme pocket [chemical binding]; other site 743720004319 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 743720004320 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 743720004321 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 743720004322 putative aromatic amino acid binding site; other site 743720004323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720004324 Walker A motif; other site 743720004325 ATP binding site [chemical binding]; other site 743720004326 Walker B motif; other site 743720004327 arginine finger; other site 743720004328 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 743720004329 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 743720004330 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 743720004331 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 743720004332 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 743720004333 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 743720004334 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913 743720004335 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 743720004336 Acyl transferase domain; Region: Acyl_transf_1; cl08282 743720004337 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 743720004338 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 743720004339 Malonate transporter MadL subunit; Region: MadL; cl04273 743720004340 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 743720004341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004342 Helix-turn-helix domains; Region: HTH; cl00088 743720004343 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 743720004344 putative dimerization interface [polypeptide binding]; other site 743720004345 Potato inhibitor I family; Region: potato_inhibit; cl15459 743720004346 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 743720004347 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 743720004348 Walker A/P-loop; other site 743720004349 ATP binding site [chemical binding]; other site 743720004350 Q-loop/lid; other site 743720004351 ABC transporter signature motif; other site 743720004352 Walker B; other site 743720004353 D-loop; other site 743720004354 H-loop/switch region; other site 743720004355 ABC-2 type transporter; Region: ABC2_membrane; cl11417 743720004356 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 743720004357 putative active site [active] 743720004358 putative CoA binding site [chemical binding]; other site 743720004359 nudix motif; other site 743720004360 metal binding site [ion binding]; metal-binding site 743720004361 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 743720004362 trimer interface [polypeptide binding]; other site 743720004363 putative metal binding site [ion binding]; other site 743720004364 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 743720004365 Predicted membrane protein [Function unknown]; Region: COG3650 743720004366 Protein of unknown function, DUF488; Region: DUF488; cl01246 743720004367 NIPSNAP; Region: NIPSNAP; pfam07978 743720004368 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 743720004369 Helix-turn-helix domains; Region: HTH; cl00088 743720004370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720004371 dimerization interface [polypeptide binding]; other site 743720004372 Predicted membrane protein [Function unknown]; Region: COG4125 743720004373 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 743720004374 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 743720004375 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 743720004376 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 743720004377 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 743720004378 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 743720004379 active site 743720004380 GMP synthase; Reviewed; Region: guaA; PRK00074 743720004381 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 743720004382 AMP/PPi binding site [chemical binding]; other site 743720004383 candidate oxyanion hole; other site 743720004384 catalytic triad [active] 743720004385 potential glutamine specificity residues [chemical binding]; other site 743720004386 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 743720004387 ATP Binding subdomain [chemical binding]; other site 743720004388 Ligand Binding sites [chemical binding]; other site 743720004389 Dimerization subdomain; other site 743720004390 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 743720004391 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720004392 metal binding site [ion binding]; metal-binding site 743720004393 active site 743720004394 I-site; other site 743720004395 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720004396 Predicted membrane protein [Function unknown]; Region: COG2860 743720004397 UPF0126 domain; Region: UPF0126; pfam03458 743720004398 UPF0126 domain; Region: UPF0126; pfam03458 743720004399 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 743720004400 Helix-turn-helix domains; Region: HTH; cl00088 743720004401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720004402 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 743720004403 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 743720004404 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720004405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720004406 dimer interface [polypeptide binding]; other site 743720004407 conserved gate region; other site 743720004408 putative PBP binding loops; other site 743720004409 ABC-ATPase subunit interface; other site 743720004410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720004411 dimer interface [polypeptide binding]; other site 743720004412 conserved gate region; other site 743720004413 putative PBP binding loops; other site 743720004414 ABC-ATPase subunit interface; other site 743720004415 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 743720004416 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 743720004417 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 743720004418 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 743720004419 nucleoside/Zn binding site; other site 743720004420 dimer interface [polypeptide binding]; other site 743720004421 catalytic motif [active] 743720004422 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 743720004423 short chain dehydrogenase; Provisional; Region: PRK06482 743720004424 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 743720004425 NADP binding site [chemical binding]; other site 743720004426 active site 743720004427 steroid binding site; other site 743720004428 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004429 Helix-turn-helix domains; Region: HTH; cl00088 743720004430 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 743720004431 putative effector binding pocket; other site 743720004432 putative dimerization interface [polypeptide binding]; other site 743720004433 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 743720004434 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720004435 substrate binding pocket [chemical binding]; other site 743720004436 membrane-bound complex binding site; other site 743720004437 hinge residues; other site 743720004438 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 743720004439 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720004440 catalytic residue [active] 743720004441 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 743720004442 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 743720004443 dimerization interface [polypeptide binding]; other site 743720004444 ATP binding site [chemical binding]; other site 743720004445 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 743720004446 dimerization interface [polypeptide binding]; other site 743720004447 ATP binding site [chemical binding]; other site 743720004448 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 743720004449 putative active site [active] 743720004450 catalytic triad [active] 743720004451 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 743720004452 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 743720004453 Pirin-related protein [General function prediction only]; Region: COG1741 743720004454 Cupin domain; Region: Cupin_2; cl09118 743720004455 LysR family transcriptional regulator; Provisional; Region: PRK14997 743720004456 Helix-turn-helix domains; Region: HTH; cl00088 743720004457 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720004458 putative effector binding pocket; other site 743720004459 dimerization interface [polypeptide binding]; other site 743720004460 methionine aminotransferase; Validated; Region: PRK09082 743720004461 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720004462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720004463 homodimer interface [polypeptide binding]; other site 743720004464 catalytic residue [active] 743720004465 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 743720004466 Predicted amidohydrolase [General function prediction only]; Region: COG0388 743720004467 putative active site [active] 743720004468 catalytic triad [active] 743720004469 multimer interface [polypeptide binding]; other site 743720004470 dimer interface [polypeptide binding]; other site 743720004471 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 743720004472 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 743720004473 putative NAD(P) binding site [chemical binding]; other site 743720004474 putative substrate binding site [chemical binding]; other site 743720004475 catalytic Zn binding site [ion binding]; other site 743720004476 structural Zn binding site [ion binding]; other site 743720004477 dimer interface [polypeptide binding]; other site 743720004478 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004479 Helix-turn-helix domains; Region: HTH; cl00088 743720004480 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720004481 dimerization interface [polypeptide binding]; other site 743720004482 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743720004483 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720004484 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 743720004485 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 743720004486 NAD(P) binding site [chemical binding]; other site 743720004487 catalytic residues [active] 743720004488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720004489 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 743720004490 Peptidase C26; Region: Peptidase_C26; pfam07722 743720004491 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 743720004492 catalytic triad [active] 743720004493 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 743720004494 Spore germination protein; Region: Spore_permease; cl15802 743720004495 2-isopropylmalate synthase; Validated; Region: PRK03739 743720004496 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 743720004497 active site 743720004498 catalytic residues [active] 743720004499 metal binding site [ion binding]; metal-binding site 743720004500 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 743720004501 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 743720004502 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743720004503 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720004504 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 743720004505 putative C-terminal domain interface [polypeptide binding]; other site 743720004506 putative GSH binding site (G-site) [chemical binding]; other site 743720004507 putative dimer interface [polypeptide binding]; other site 743720004508 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 743720004509 putative N-terminal domain interface [polypeptide binding]; other site 743720004510 putative dimer interface [polypeptide binding]; other site 743720004511 putative substrate binding pocket (H-site) [chemical binding]; other site 743720004512 Peptidase family M23; Region: Peptidase_M23; pfam01551 743720004513 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 743720004514 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 743720004515 generic binding surface II; other site 743720004516 generic binding surface I; other site 743720004517 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720004518 dimerization interface [polypeptide binding]; other site 743720004519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004520 Helix-turn-helix domains; Region: HTH; cl00088 743720004521 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 743720004522 putative effector binding pocket; other site 743720004523 putative dimerization interface [polypeptide binding]; other site 743720004524 short chain dehydrogenase; Provisional; Region: PRK06197 743720004525 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 743720004526 putative NAD(P) binding site [chemical binding]; other site 743720004527 active site 743720004528 ATP/ADP translocase [Energy production and conversion]; Region: COG3202; cl03940 743720004529 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 743720004530 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 743720004531 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 743720004532 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720004533 FeS/SAM binding site; other site 743720004534 TRAM domain; Region: TRAM; cl01282 743720004535 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 743720004536 catalytic residues [active] 743720004537 catalytic nucleophile [active] 743720004538 Recombinase; Region: Recombinase; pfam07508 743720004539 Myosin tail; Region: Myosin_tail_1; pfam01576 743720004540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 743720004541 cofactor binding site; other site 743720004542 DNA binding site [nucleotide binding] 743720004543 substrate interaction site [chemical binding]; other site 743720004544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 743720004545 DHH family; Region: DHH; pfam01368 743720004546 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 743720004547 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 743720004548 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 743720004549 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 743720004550 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720004551 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 743720004552 non-specific DNA binding site [nucleotide binding]; other site 743720004553 salt bridge; other site 743720004554 sequence-specific DNA binding site [nucleotide binding]; other site 743720004555 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 743720004556 Catalytic site [active] 743720004557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 743720004558 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 743720004559 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 743720004560 polymerase nucleotide-binding site; other site 743720004561 DNA-binding residues [nucleotide binding]; DNA binding site 743720004562 nucleotide binding site [chemical binding]; other site 743720004563 primase nucleotide-binding site [nucleotide binding]; other site 743720004564 Phage associated DNA primase [General function prediction only]; Region: COG3378 743720004565 Protein of unknown function (DUF754); Region: DUF754; pfam05449 743720004566 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 743720004567 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 743720004568 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 743720004569 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 743720004570 oligomer interface [polypeptide binding]; other site 743720004571 active site residues [active] 743720004572 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 743720004573 acyl-CoA synthetase; Validated; Region: PRK07788 743720004574 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 743720004575 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 743720004576 Mu-like prophage protein [General function prediction only]; Region: COG3941 743720004577 Global regulator protein family; Region: CsrA; cl00670 743720004578 Uncharacterized protein family (UPF0257); Region: UPF0257; cl14672 743720004579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720004580 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 743720004581 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 743720004582 Catalytic site [active] 743720004583 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 743720004584 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 743720004585 active site 743720004586 DNA binding site [nucleotide binding] 743720004587 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 743720004588 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 743720004589 Preprotein binding site; other site 743720004590 SecA binding site; other site 743720004591 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 743720004592 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 743720004593 Predicted integral membrane protein [Function unknown]; Region: COG0392 743720004594 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 743720004595 Uncharacterized conserved protein [Function unknown]; Region: COG2898 743720004596 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 743720004597 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 743720004598 active site 743720004599 DNA polymerase IV; Validated; Region: PRK02406 743720004600 DNA binding site [nucleotide binding] 743720004601 META domain; Region: META; cl01245 743720004602 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 743720004603 heme binding pocket [chemical binding]; other site 743720004604 heme ligand [chemical binding]; other site 743720004605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720004606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720004607 dimer interface [polypeptide binding]; other site 743720004608 phosphorylation site [posttranslational modification] 743720004609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720004610 ATP binding site [chemical binding]; other site 743720004611 Mg2+ binding site [ion binding]; other site 743720004612 G-X-G motif; other site 743720004613 Response regulator receiver domain; Region: Response_reg; pfam00072 743720004614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720004615 active site 743720004616 phosphorylation site [posttranslational modification] 743720004617 intermolecular recognition site; other site 743720004618 dimerization interface [polypeptide binding]; other site 743720004619 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 743720004620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720004621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720004622 active site 743720004623 phosphorylation site [posttranslational modification] 743720004624 intermolecular recognition site; other site 743720004625 dimerization interface [polypeptide binding]; other site 743720004626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720004627 DNA binding site [nucleotide binding] 743720004628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720004629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720004630 dimerization interface [polypeptide binding]; other site 743720004631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720004632 dimer interface [polypeptide binding]; other site 743720004633 phosphorylation site [posttranslational modification] 743720004634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720004635 ATP binding site [chemical binding]; other site 743720004636 Mg2+ binding site [ion binding]; other site 743720004637 G-X-G motif; other site 743720004638 outer membrane receptor FepA; Provisional; Region: PRK13524 743720004639 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720004640 N-terminal plug; other site 743720004641 ligand-binding site [chemical binding]; other site 743720004642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720004643 S-adenosylmethionine binding site [chemical binding]; other site 743720004644 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 743720004645 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720004646 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 743720004647 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 743720004648 siderophore binding site; other site 743720004649 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720004650 ABC-ATPase subunit interface; other site 743720004651 dimer interface [polypeptide binding]; other site 743720004652 putative PBP binding regions; other site 743720004653 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 743720004654 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 743720004655 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720004656 ABC-ATPase subunit interface; other site 743720004657 dimer interface [polypeptide binding]; other site 743720004658 putative PBP binding regions; other site 743720004659 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 743720004660 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 743720004661 Walker A/P-loop; other site 743720004662 ATP binding site [chemical binding]; other site 743720004663 Q-loop/lid; other site 743720004664 ABC transporter signature motif; other site 743720004665 Walker B; other site 743720004666 D-loop; other site 743720004667 H-loop/switch region; other site 743720004668 cysteine synthase B; Region: cysM; TIGR01138 743720004669 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 743720004670 dimer interface [polypeptide binding]; other site 743720004671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720004672 catalytic residue [active] 743720004673 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 743720004674 TRAM domain; Region: TRAM; cl01282 743720004675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720004676 S-adenosylmethionine binding site [chemical binding]; other site 743720004677 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 743720004678 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 743720004679 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 743720004680 synthetase active site [active] 743720004681 NTP binding site [chemical binding]; other site 743720004682 metal binding site [ion binding]; metal-binding site 743720004683 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 743720004684 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 743720004685 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 743720004686 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 743720004687 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 743720004688 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 743720004689 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 743720004690 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 743720004691 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 743720004692 active site 743720004693 substrate binding site [chemical binding]; other site 743720004694 cosubstrate binding site; other site 743720004695 catalytic site [active] 743720004696 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 743720004697 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 743720004698 dimerization interface [polypeptide binding]; other site 743720004699 putative ATP binding site [chemical binding]; other site 743720004700 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 743720004701 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 743720004702 Domain of unknown function DUF20; Region: UPF0118; pfam01594 743720004703 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720004704 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 743720004705 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 743720004706 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 743720004707 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 743720004708 ArsC family; Region: ArsC; pfam03960 743720004709 catalytic residues [active] 743720004710 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 743720004711 PilZ domain; Region: PilZ; cl01260 743720004712 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 743720004713 catalytic residues [active] 743720004714 Acylphosphatase; Region: Acylphosphatase; cl00551 743720004715 prolyl-tRNA synthetase; Provisional; Region: PRK09194 743720004716 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 743720004717 dimer interface [polypeptide binding]; other site 743720004718 motif 1; other site 743720004719 active site 743720004720 motif 2; other site 743720004721 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 743720004722 putative deacylase active site [active] 743720004723 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 743720004724 active site 743720004725 motif 3; other site 743720004726 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 743720004727 anticodon binding site; other site 743720004728 outer membrane porin, OprD family; Region: OprD; pfam03573 743720004729 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 743720004730 SlyX; Region: SlyX; cl01090 743720004731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 743720004732 putative transposase OrfB; Reviewed; Region: PHA02517 743720004733 Integrase core domain; Region: rve; cl01316 743720004734 Integrase core domain; Region: rve_3; cl15866 743720004735 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 743720004736 DNA-binding site [nucleotide binding]; DNA binding site 743720004737 RNA-binding motif; other site 743720004738 Ferritin-like domain; Region: Ferritin; pfam00210 743720004739 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 743720004740 dimerization interface [polypeptide binding]; other site 743720004741 DPS ferroxidase diiron center [ion binding]; other site 743720004742 ion pore; other site 743720004743 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 743720004744 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 743720004745 dimer interface [polypeptide binding]; other site 743720004746 anticodon binding site; other site 743720004747 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 743720004748 homodimer interface [polypeptide binding]; other site 743720004749 motif 1; other site 743720004750 active site 743720004751 motif 2; other site 743720004752 GAD domain; Region: GAD; pfam02938 743720004753 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 743720004754 active site 743720004755 motif 3; other site 743720004756 Transcriptional regulator; Region: Transcrip_reg; cl00361 743720004757 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 743720004758 active site 743720004759 putative DNA-binding cleft [nucleotide binding]; other site 743720004760 dimer interface [polypeptide binding]; other site 743720004761 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 743720004762 RuvA N terminal domain; Region: RuvA_N; pfam01330 743720004763 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 743720004764 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 743720004765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720004766 Walker A motif; other site 743720004767 ATP binding site [chemical binding]; other site 743720004768 Walker B motif; other site 743720004769 arginine finger; other site 743720004770 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 743720004771 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743720004772 active site 743720004773 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 743720004774 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 743720004775 TolA protein; Region: tolA_full; TIGR02794 743720004776 Gram-negative bacterial tonB protein; Region: TonB; cl10048 743720004777 translocation protein TolB; Provisional; Region: tolB; PRK00178 743720004778 TolB amino-terminal domain; Region: TolB_N; cl00639 743720004779 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743720004780 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743720004781 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743720004782 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720004783 ligand binding site [chemical binding]; other site 743720004784 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 743720004785 Tetratricopeptide repeat; Region: TPR_6; pfam13174 743720004786 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 743720004787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720004788 FeS/SAM binding site; other site 743720004789 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 743720004790 Ligand Binding Site [chemical binding]; other site 743720004791 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 743720004792 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 743720004793 homodimer interface [polypeptide binding]; other site 743720004794 substrate-cofactor binding pocket; other site 743720004795 catalytic residue [active] 743720004796 Quinolinate synthetase A protein; Region: NadA; cl00420 743720004797 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 743720004798 Peptidase family M48; Region: Peptidase_M48; cl12018 743720004799 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 743720004800 CPxP motif; other site 743720004801 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 743720004802 catalytic triad [active] 743720004803 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 743720004804 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 743720004805 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 743720004806 dihydrodipicolinate synthase; Region: dapA; TIGR00674 743720004807 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 743720004808 dimer interface [polypeptide binding]; other site 743720004809 active site 743720004810 catalytic residue [active] 743720004811 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 743720004812 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 743720004813 ATP binding site [chemical binding]; other site 743720004814 active site 743720004815 substrate binding site [chemical binding]; other site 743720004816 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 743720004817 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 743720004818 catalytic residues [active] 743720004819 catalytic nucleophile [active] 743720004820 Presynaptic Site I dimer interface [polypeptide binding]; other site 743720004821 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 743720004822 Synaptic Flat tetramer interface [polypeptide binding]; other site 743720004823 Synaptic Site I dimer interface [polypeptide binding]; other site 743720004824 DNA binding site [nucleotide binding] 743720004825 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 743720004826 DNA-binding interface [nucleotide binding]; DNA binding site 743720004827 flagellar accessory protein FlaH; Validated; Region: PRK06067 743720004828 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 743720004829 Proline dehydrogenase; Region: Pro_dh; cl03282 743720004830 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 743720004831 Glutamate binding site [chemical binding]; other site 743720004832 NAD binding site [chemical binding]; other site 743720004833 catalytic residues [active] 743720004834 Sodium:solute symporter family; Region: SSF; cl00456 743720004835 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 743720004836 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 743720004837 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 743720004838 Transglycosylase; Region: Transgly; cl07896 743720004839 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720004840 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743720004841 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 743720004842 active site 743720004843 catalytic tetrad [active] 743720004844 ATP-dependent helicase HepA; Validated; Region: PRK04914 743720004845 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720004846 ATP binding site [chemical binding]; other site 743720004847 putative Mg++ binding site [ion binding]; other site 743720004848 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720004849 nucleotide binding region [chemical binding]; other site 743720004850 ATP-binding site [chemical binding]; other site 743720004851 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 743720004852 Fusaric acid resistance protein family; Region: FUSC; pfam04632 743720004853 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 743720004854 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 743720004855 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 743720004856 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720004857 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720004858 cytosine deaminase; Provisional; Region: PRK09230 743720004859 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 743720004860 active site 743720004861 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 743720004862 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 743720004863 Helix-turn-helix domains; Region: HTH; cl00088 743720004864 Sodium:solute symporter family; Region: SSF; cl00456 743720004865 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 743720004866 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 743720004867 dimer interaction site [polypeptide binding]; other site 743720004868 substrate-binding tunnel; other site 743720004869 active site 743720004870 catalytic site [active] 743720004871 substrate binding site [chemical binding]; other site 743720004872 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 743720004873 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720004874 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720004875 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 743720004876 AMP-binding enzyme; Region: AMP-binding; cl15778 743720004877 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720004878 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 743720004879 AMP-binding enzyme; Region: AMP-binding; cl15778 743720004880 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720004881 UV-endonuclease UvdE; Region: UvdE; cl10036 743720004882 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 743720004883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720004884 dimer interface [polypeptide binding]; other site 743720004885 conserved gate region; other site 743720004886 putative PBP binding loops; other site 743720004887 ABC-ATPase subunit interface; other site 743720004888 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 743720004889 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720004890 Walker A/P-loop; other site 743720004891 ATP binding site [chemical binding]; other site 743720004892 Q-loop/lid; other site 743720004893 ABC transporter signature motif; other site 743720004894 Walker B; other site 743720004895 D-loop; other site 743720004896 H-loop/switch region; other site 743720004897 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 743720004898 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 743720004899 substrate binding pocket [chemical binding]; other site 743720004900 membrane-bound complex binding site; other site 743720004901 hinge residues; other site 743720004902 selenophosphate synthetase; Provisional; Region: PRK00943 743720004903 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 743720004904 dimerization interface [polypeptide binding]; other site 743720004905 putative ATP binding site [chemical binding]; other site 743720004906 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 743720004907 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 743720004908 active site residue [active] 743720004909 Transposase IS200 like; Region: Y1_Tnp; cl00848 743720004910 putative cyanate transporter; Provisional; Region: cynX; PRK09705 743720004911 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 743720004912 Helix-turn-helix domains; Region: HTH; cl00088 743720004913 transcriptional regulator; Provisional; Region: PRK10632 743720004914 Helix-turn-helix domains; Region: HTH; cl00088 743720004915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720004916 dimerization interface [polypeptide binding]; other site 743720004917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720004918 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720004919 putative substrate translocation pore; other site 743720004920 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720004921 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004922 Helix-turn-helix domains; Region: HTH; cl00088 743720004923 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720004924 dimerization interface [polypeptide binding]; other site 743720004925 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720004926 dimerization interface [polypeptide binding]; other site 743720004927 putative DNA binding site [nucleotide binding]; other site 743720004928 putative Zn2+ binding site [ion binding]; other site 743720004929 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 743720004930 Di-iron ligands [ion binding]; other site 743720004931 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720004932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720004933 Response regulator receiver domain; Region: Response_reg; pfam00072 743720004934 active site 743720004935 phosphorylation site [posttranslational modification] 743720004936 intermolecular recognition site; other site 743720004937 dimerization interface [polypeptide binding]; other site 743720004938 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720004939 DNA binding residues [nucleotide binding] 743720004940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720004941 dimer interface [polypeptide binding]; other site 743720004942 phosphorylation site [posttranslational modification] 743720004943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720004944 ATP binding site [chemical binding]; other site 743720004945 Mg2+ binding site [ion binding]; other site 743720004946 G-X-G motif; other site 743720004947 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720004948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720004949 active site 743720004950 phosphorylation site [posttranslational modification] 743720004951 intermolecular recognition site; other site 743720004952 dimerization interface [polypeptide binding]; other site 743720004953 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 743720004954 putative kissing complex interaction region; other site 743720004955 putative RNA binding sites [nucleotide binding]; other site 743720004956 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720004957 DNA binding residues [nucleotide binding] 743720004958 dimerization interface [polypeptide binding]; other site 743720004959 Predicted amidohydrolase [General function prediction only]; Region: COG0388 743720004960 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 743720004961 putative active site [active] 743720004962 catalytic triad [active] 743720004963 putative dimer interface [polypeptide binding]; other site 743720004964 amino acid transporter; Region: 2A0306; TIGR00909 743720004965 Spore germination protein; Region: Spore_permease; cl15802 743720004966 Restriction endonuclease; Region: Mrr_cat; cl00516 743720004967 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 743720004968 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720004969 ATP binding site [chemical binding]; other site 743720004970 putative Mg++ binding site [ion binding]; other site 743720004971 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720004972 nucleotide binding region [chemical binding]; other site 743720004973 ATP-binding site [chemical binding]; other site 743720004974 Helicase associated domain (HA2); Region: HA2; cl04503 743720004975 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 743720004976 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 743720004977 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720004978 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 743720004979 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 743720004980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720004981 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 743720004982 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 743720004983 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 743720004984 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 743720004985 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 743720004986 putative molybdopterin cofactor binding site [chemical binding]; other site 743720004987 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 743720004988 putative molybdopterin cofactor binding site; other site 743720004989 oxidoreductase; Provisional; Region: PRK06128 743720004990 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 743720004991 NAD binding site [chemical binding]; other site 743720004992 metal binding site [ion binding]; metal-binding site 743720004993 active site 743720004994 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 743720004995 active site 743720004996 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 743720004997 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720004998 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720004999 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005000 dimer interface [polypeptide binding]; other site 743720005001 putative CheW interface [polypeptide binding]; other site 743720005002 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 743720005003 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 743720005004 active site pocket [active] 743720005005 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743720005006 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720005007 DNA binding site [nucleotide binding] 743720005008 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 743720005009 putative dimerization interface [polypeptide binding]; other site 743720005010 putative ligand binding site [chemical binding]; other site 743720005011 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 743720005012 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 743720005013 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743720005014 active site 743720005015 nucleotide binding site [chemical binding]; other site 743720005016 HIGH motif; other site 743720005017 KMSKS motif; other site 743720005018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720005019 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 743720005020 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 743720005021 NAD binding site [chemical binding]; other site 743720005022 catalytic Zn binding site [ion binding]; other site 743720005023 structural Zn binding site [ion binding]; other site 743720005024 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 743720005025 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 743720005026 dinuclear metal binding motif [ion binding]; other site 743720005027 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 743720005028 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 743720005029 Cu(I) binding site [ion binding]; other site 743720005030 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 743720005031 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720005032 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720005033 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720005034 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005035 dimer interface [polypeptide binding]; other site 743720005036 putative CheW interface [polypeptide binding]; other site 743720005037 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 743720005038 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 743720005039 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 743720005040 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 743720005041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 743720005042 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 743720005043 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 743720005044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720005045 dimer interface [polypeptide binding]; other site 743720005046 phosphorylation site [posttranslational modification] 743720005047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005048 ATP binding site [chemical binding]; other site 743720005049 Mg2+ binding site [ion binding]; other site 743720005050 G-X-G motif; other site 743720005051 Response regulator receiver domain; Region: Response_reg; pfam00072 743720005052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005053 active site 743720005054 phosphorylation site [posttranslational modification] 743720005055 intermolecular recognition site; other site 743720005056 dimerization interface [polypeptide binding]; other site 743720005057 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743720005058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720005059 dimer interface [polypeptide binding]; other site 743720005060 phosphorylation site [posttranslational modification] 743720005061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005062 ATP binding site [chemical binding]; other site 743720005063 Mg2+ binding site [ion binding]; other site 743720005064 G-X-G motif; other site 743720005065 Response regulator receiver domain; Region: Response_reg; pfam00072 743720005066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005067 active site 743720005068 phosphorylation site [posttranslational modification] 743720005069 intermolecular recognition site; other site 743720005070 dimerization interface [polypeptide binding]; other site 743720005071 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720005072 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 743720005073 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720005074 dimerization interface [polypeptide binding]; other site 743720005075 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720005076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005077 dimer interface [polypeptide binding]; other site 743720005078 putative CheW interface [polypeptide binding]; other site 743720005079 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720005080 PAS fold; Region: PAS_4; pfam08448 743720005081 PAS fold; Region: PAS_4; pfam08448 743720005082 PAS fold; Region: PAS_4; pfam08448 743720005083 histidine kinase; Provisional; Region: PRK13557 743720005084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005085 ATP binding site [chemical binding]; other site 743720005086 G-X-G motif; other site 743720005087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005088 active site 743720005089 phosphorylation site [posttranslational modification] 743720005090 intermolecular recognition site; other site 743720005091 dimerization interface [polypeptide binding]; other site 743720005092 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 743720005093 nudix motif; other site 743720005094 DoxX; Region: DoxX; cl00976 743720005095 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 743720005096 PAS fold; Region: PAS_4; pfam08448 743720005097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720005098 PAS domain; Region: PAS_9; pfam13426 743720005099 putative active site [active] 743720005100 heme pocket [chemical binding]; other site 743720005101 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 743720005102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720005103 dimer interface [polypeptide binding]; other site 743720005104 phosphorylation site [posttranslational modification] 743720005105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005106 ATP binding site [chemical binding]; other site 743720005107 G-X-G motif; other site 743720005108 Response regulator receiver domain; Region: Response_reg; pfam00072 743720005109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005110 active site 743720005111 phosphorylation site [posttranslational modification] 743720005112 intermolecular recognition site; other site 743720005113 dimerization interface [polypeptide binding]; other site 743720005114 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 743720005115 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720005116 LysE type translocator; Region: LysE; cl00565 743720005117 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 743720005118 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 743720005119 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 743720005120 NAD(P) binding site [chemical binding]; other site 743720005121 active site 743720005122 Helix-turn-helix domains; Region: HTH; cl00088 743720005123 Isochorismatase family; Region: Isochorismatase; pfam00857 743720005124 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 743720005125 catalytic triad [active] 743720005126 conserved cis-peptide bond; other site 743720005127 Sulfate transporter family; Region: Sulfate_transp; cl15842 743720005128 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 743720005129 Sulfate transporter family; Region: Sulfate_transp; cl15842 743720005130 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 743720005131 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 743720005132 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 743720005133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720005134 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 743720005135 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 743720005136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720005137 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 743720005138 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 743720005139 Cache domain; Region: Cache_1; pfam02743 743720005140 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720005141 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720005142 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005143 dimer interface [polypeptide binding]; other site 743720005144 putative CheW interface [polypeptide binding]; other site 743720005145 Cache domain; Region: Cache_1; pfam02743 743720005146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720005147 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720005148 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005149 dimer interface [polypeptide binding]; other site 743720005150 putative CheW interface [polypeptide binding]; other site 743720005151 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 743720005152 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720005153 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 743720005154 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 743720005155 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 743720005156 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720005157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720005158 Bacitracin resistance protein BacA; Region: BacA; cl00858 743720005159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005160 metabolite-proton symporter; Region: 2A0106; TIGR00883 743720005161 putative substrate translocation pore; other site 743720005162 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 743720005163 HIT family signature motif; other site 743720005164 catalytic residue [active] 743720005165 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 743720005166 EamA-like transporter family; Region: EamA; cl01037 743720005167 EamA-like transporter family; Region: EamA; cl01037 743720005168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720005169 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 743720005170 MFS transport protein AraJ; Provisional; Region: PRK10091 743720005171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005172 putative substrate translocation pore; other site 743720005173 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 743720005174 peroxiredoxin; Region: AhpC; TIGR03137 743720005175 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 743720005176 dimer interface [polypeptide binding]; other site 743720005177 decamer (pentamer of dimers) interface [polypeptide binding]; other site 743720005178 catalytic triad [active] 743720005179 peroxidatic and resolving cysteines [active] 743720005180 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 743720005181 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 743720005182 catalytic residue [active] 743720005183 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 743720005184 catalytic residues [active] 743720005185 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720005186 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 743720005187 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 743720005188 active site 743720005189 Zn binding site [ion binding]; other site 743720005190 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 743720005191 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 743720005192 DEAD_2; Region: DEAD_2; pfam06733 743720005193 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720005194 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 743720005195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720005196 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743720005197 putative active site [active] 743720005198 heme pocket [chemical binding]; other site 743720005199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720005200 dimer interface [polypeptide binding]; other site 743720005201 phosphorylation site [posttranslational modification] 743720005202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005203 ATP binding site [chemical binding]; other site 743720005204 Mg2+ binding site [ion binding]; other site 743720005205 G-X-G motif; other site 743720005206 circadian clock protein KaiC; Reviewed; Region: PRK09302 743720005207 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720005208 Walker A motif; other site 743720005209 ATP binding site [chemical binding]; other site 743720005210 Walker B motif; other site 743720005211 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720005212 Walker A motif; other site 743720005213 ATP binding site [chemical binding]; other site 743720005214 Walker B motif; other site 743720005215 Response regulator receiver domain; Region: Response_reg; pfam00072 743720005216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005217 active site 743720005218 phosphorylation site [posttranslational modification] 743720005219 intermolecular recognition site; other site 743720005220 dimerization interface [polypeptide binding]; other site 743720005221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720005222 dimer interface [polypeptide binding]; other site 743720005223 phosphorylation site [posttranslational modification] 743720005224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005225 ATP binding site [chemical binding]; other site 743720005226 Mg2+ binding site [ion binding]; other site 743720005227 G-X-G motif; other site 743720005228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005229 active site 743720005230 phosphorylation site [posttranslational modification] 743720005231 intermolecular recognition site; other site 743720005232 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 743720005233 FMN binding site [chemical binding]; other site 743720005234 dimer interface [polypeptide binding]; other site 743720005235 MatE; Region: MatE; cl10513 743720005236 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 743720005237 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 743720005238 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 743720005239 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 743720005240 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 743720005241 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 743720005242 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 743720005243 Substrate binding site; other site 743720005244 Cupin domain; Region: Cupin_2; cl09118 743720005245 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 743720005246 putative glycosyl transferase; Provisional; Region: PRK10063 743720005247 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720005248 active site 743720005249 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 743720005250 active site 743720005251 GDP-Mannose binding site [chemical binding]; other site 743720005252 dimer interface [polypeptide binding]; other site 743720005253 modified nudix motif 743720005254 metal binding site [ion binding]; metal-binding site 743720005255 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 743720005256 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 743720005257 NADP binding site [chemical binding]; other site 743720005258 active site 743720005259 putative substrate binding site [chemical binding]; other site 743720005260 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 743720005261 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 743720005262 NADP-binding site; other site 743720005263 homotetramer interface [polypeptide binding]; other site 743720005264 substrate binding site [chemical binding]; other site 743720005265 homodimer interface [polypeptide binding]; other site 743720005266 active site 743720005267 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720005268 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 743720005269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720005270 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 743720005271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720005272 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 743720005273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720005274 Bacterial sugar transferase; Region: Bac_transf; cl00939 743720005275 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 743720005276 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 743720005277 Chain length determinant protein; Region: Wzz; cl15801 743720005278 Chain length determinant protein; Region: Wzz; cl15801 743720005279 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720005280 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 743720005281 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 743720005282 SLBB domain; Region: SLBB; pfam10531 743720005283 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 743720005284 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 743720005285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720005286 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 743720005287 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720005288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 743720005289 NMT1-like family; Region: NMT1_2; cl15260 743720005290 outer membrane porin, OprD family; Region: OprD; pfam03573 743720005291 PrpF protein; Region: PrpF; pfam04303 743720005292 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 743720005293 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720005294 Helix-turn-helix domains; Region: HTH; cl00088 743720005295 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 743720005296 putative dimerization interface [polypeptide binding]; other site 743720005297 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 743720005298 PrpF protein; Region: PrpF; pfam04303 743720005299 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 743720005300 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 743720005301 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 743720005302 Citrate transporter; Region: CitMHS; pfam03600 743720005303 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 743720005304 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743720005305 catalytic residues [active] 743720005306 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 743720005307 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 743720005308 DNA binding residues [nucleotide binding] 743720005309 putative dimer interface [polypeptide binding]; other site 743720005310 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 743720005311 isovaleryl-CoA dehydrogenase; Region: PLN02519 743720005312 substrate binding site [chemical binding]; other site 743720005313 FAD binding site [chemical binding]; other site 743720005314 catalytic base [active] 743720005315 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 743720005316 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 743720005317 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 743720005318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720005319 substrate binding site [chemical binding]; other site 743720005320 oxyanion hole (OAH) forming residues; other site 743720005321 trimer interface [polypeptide binding]; other site 743720005322 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 743720005323 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720005324 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720005325 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 743720005326 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743720005327 carboxyltransferase (CT) interaction site; other site 743720005328 biotinylation site [posttranslational modification]; other site 743720005329 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 743720005330 active site 743720005331 catalytic residues [active] 743720005332 metal binding site [ion binding]; metal-binding site 743720005333 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 743720005334 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 743720005335 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 743720005336 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 743720005337 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 743720005338 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720005339 dimer interface [polypeptide binding]; other site 743720005340 active site 743720005341 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 743720005342 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 743720005343 putative acyl-acceptor binding pocket; other site 743720005344 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 743720005345 active site 743720005346 nucleophile elbow; other site 743720005347 Predicted ATPase [General function prediction only]; Region: COG1485 743720005348 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 743720005349 Walker A/P-loop; other site 743720005350 ATP binding site [chemical binding]; other site 743720005351 Q-loop/lid; other site 743720005352 ABC transporter signature motif; other site 743720005353 Walker B; other site 743720005354 D-loop; other site 743720005355 H-loop/switch region; other site 743720005356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720005357 non-specific DNA binding site [nucleotide binding]; other site 743720005358 salt bridge; other site 743720005359 sequence-specific DNA binding site [nucleotide binding]; other site 743720005360 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 743720005361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720005362 Coenzyme A binding pocket [chemical binding]; other site 743720005363 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 743720005364 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 743720005365 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 743720005366 putative ADP-ribose binding site [chemical binding]; other site 743720005367 putative active site [active] 743720005368 pyridoxamine kinase; Validated; Region: PRK05756 743720005369 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 743720005370 pyridoxal binding site [chemical binding]; other site 743720005371 dimer interface [polypeptide binding]; other site 743720005372 ATP binding site [chemical binding]; other site 743720005373 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 743720005374 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 743720005375 ligand binding site [chemical binding]; other site 743720005376 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 743720005377 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 743720005378 Walker A/P-loop; other site 743720005379 ATP binding site [chemical binding]; other site 743720005380 Q-loop/lid; other site 743720005381 ABC transporter signature motif; other site 743720005382 Walker B; other site 743720005383 D-loop; other site 743720005384 H-loop/switch region; other site 743720005385 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 743720005386 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 743720005387 TM-ABC transporter signature motif; other site 743720005388 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743720005389 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720005390 DNA binding site [nucleotide binding] 743720005391 domain linker motif; other site 743720005392 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 743720005393 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 743720005394 substrate binding site [chemical binding]; other site 743720005395 dimer interface [polypeptide binding]; other site 743720005396 ATP binding site [chemical binding]; other site 743720005397 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 743720005398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 743720005399 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 743720005400 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 743720005401 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 743720005402 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 743720005403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720005404 Walker A/P-loop; other site 743720005405 ATP binding site [chemical binding]; other site 743720005406 Q-loop/lid; other site 743720005407 ABC transporter signature motif; other site 743720005408 Walker B; other site 743720005409 D-loop; other site 743720005410 H-loop/switch region; other site 743720005411 TOBE domain; Region: TOBE_2; cl01440 743720005412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720005413 dimer interface [polypeptide binding]; other site 743720005414 conserved gate region; other site 743720005415 putative PBP binding loops; other site 743720005416 ABC-ATPase subunit interface; other site 743720005417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720005418 dimer interface [polypeptide binding]; other site 743720005419 conserved gate region; other site 743720005420 putative PBP binding loops; other site 743720005421 ABC-ATPase subunit interface; other site 743720005422 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 743720005423 PglZ domain; Region: PglZ; pfam08665 743720005424 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 743720005425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720005426 transcriptional regulator protein; Region: phnR; TIGR03337 743720005427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720005428 DNA-binding site [nucleotide binding]; DNA binding site 743720005429 UTRA domain; Region: UTRA; cl01230 743720005430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005431 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720005432 putative substrate translocation pore; other site 743720005433 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743720005434 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 743720005435 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 743720005436 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 743720005437 DoxX-like family; Region: DoxX_3; pfam13781 743720005438 Protein of unknown function, DUF393; Region: DUF393; cl01136 743720005439 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720005440 PAS domain; Region: PAS_9; pfam13426 743720005441 putative active site [active] 743720005442 heme pocket [chemical binding]; other site 743720005443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720005444 PAS domain; Region: PAS_9; pfam13426 743720005445 putative active site [active] 743720005446 heme pocket [chemical binding]; other site 743720005447 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005448 dimer interface [polypeptide binding]; other site 743720005449 putative CheW interface [polypeptide binding]; other site 743720005450 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743720005451 Helix-turn-helix domains; Region: HTH; cl00088 743720005452 Predicted permeases [General function prediction only]; Region: RarD; COG2962 743720005453 EamA-like transporter family; Region: EamA; cl01037 743720005454 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 743720005455 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 743720005456 Peptidase family U32; Region: Peptidase_U32; cl03113 743720005457 Collagenase; Region: DUF3656; pfam12392 743720005458 hypothetical protein; Provisional; Region: PRK10396 743720005459 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 743720005460 SEC-C motif; Region: SEC-C; pfam02810 743720005461 HDOD domain; Region: HDOD; pfam08668 743720005462 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 743720005463 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720005464 metal binding site [ion binding]; metal-binding site 743720005465 active site 743720005466 I-site; other site 743720005467 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 743720005468 Cupin domain; Region: Cupin_2; cl09118 743720005469 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 743720005470 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720005471 metal binding site [ion binding]; metal-binding site 743720005472 active site 743720005473 I-site; other site 743720005474 Ion channel; Region: Ion_trans_2; cl11596 743720005475 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 743720005476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720005477 S-adenosylmethionine binding site [chemical binding]; other site 743720005478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720005479 Coenzyme A binding pocket [chemical binding]; other site 743720005480 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 743720005481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720005482 binding surface 743720005483 TPR motif; other site 743720005484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720005485 binding surface 743720005486 TPR motif; other site 743720005487 TPR repeat; Region: TPR_11; pfam13414 743720005488 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 743720005489 dimer interface [polypeptide binding]; other site 743720005490 putative radical transfer pathway; other site 743720005491 diiron center [ion binding]; other site 743720005492 tyrosyl radical; other site 743720005493 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 743720005494 ATP cone domain; Region: ATP-cone; pfam03477 743720005495 ATP cone domain; Region: ATP-cone; pfam03477 743720005496 Class I ribonucleotide reductase; Region: RNR_I; cd01679 743720005497 active site 743720005498 dimer interface [polypeptide binding]; other site 743720005499 catalytic residues [active] 743720005500 effector binding site; other site 743720005501 R2 peptide binding site; other site 743720005502 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 743720005503 active site 743720005504 Septum formation topological specificity factor MinE; Region: MinE; cl00538 743720005505 cell division inhibitor MinD; Provisional; Region: PRK10818 743720005506 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 743720005507 Switch I; other site 743720005508 Switch II; other site 743720005509 septum formation inhibitor; Reviewed; Region: minC; PRK00339 743720005510 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 743720005511 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 743720005512 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720005513 Coenzyme A binding pocket [chemical binding]; other site 743720005514 Helix-turn-helix domains; Region: HTH; cl00088 743720005515 transcriptional activator TtdR; Provisional; Region: PRK09801 743720005516 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720005517 putative effector binding pocket; other site 743720005518 dimerization interface [polypeptide binding]; other site 743720005519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005520 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 743720005521 Bacterial SH3 domain; Region: SH3_3; cl02551 743720005522 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 743720005523 Helix-turn-helix domains; Region: HTH; cl00088 743720005524 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 743720005525 putative dimerization interface [polypeptide binding]; other site 743720005526 putative substrate binding pocket [chemical binding]; other site 743720005527 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 743720005528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005529 putative substrate translocation pore; other site 743720005530 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 743720005531 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 743720005532 active site 743720005533 tetramer interface [polypeptide binding]; other site 743720005534 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 743720005535 Isochorismatase family; Region: Isochorismatase; pfam00857 743720005536 catalytic triad [active] 743720005537 conserved cis-peptide bond; other site 743720005538 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720005539 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 743720005540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720005541 dimer interface [polypeptide binding]; other site 743720005542 conserved gate region; other site 743720005543 putative PBP binding loops; other site 743720005544 ABC-ATPase subunit interface; other site 743720005545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720005546 dimer interface [polypeptide binding]; other site 743720005547 conserved gate region; other site 743720005548 putative PBP binding loops; other site 743720005549 ABC-ATPase subunit interface; other site 743720005550 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14263 743720005551 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 743720005552 Walker A/P-loop; other site 743720005553 ATP binding site [chemical binding]; other site 743720005554 Q-loop/lid; other site 743720005555 ABC transporter signature motif; other site 743720005556 Walker B; other site 743720005557 D-loop; other site 743720005558 H-loop/switch region; other site 743720005559 phosphoglucomutase; Validated; Region: PRK07564 743720005560 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 743720005561 active site 743720005562 substrate binding site [chemical binding]; other site 743720005563 metal binding site [ion binding]; metal-binding site 743720005564 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720005565 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720005566 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720005567 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005568 dimer interface [polypeptide binding]; other site 743720005569 putative CheW interface [polypeptide binding]; other site 743720005570 Predicted transcriptional regulator [Transcription]; Region: COG1959 743720005571 Helix-turn-helix domains; Region: HTH; cl00088 743720005572 Helix-turn-helix domains; Region: HTH; cl00088 743720005573 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 743720005574 Cytochrome c; Region: Cytochrom_C; cl11414 743720005575 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 743720005576 serine O-acetyltransferase; Region: cysE; TIGR01172 743720005577 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 743720005578 trimer interface [polypeptide binding]; other site 743720005579 active site 743720005580 substrate binding site [chemical binding]; other site 743720005581 CoA binding site [chemical binding]; other site 743720005582 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 743720005583 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720005584 ABC-ATPase subunit interface; other site 743720005585 dimer interface [polypeptide binding]; other site 743720005586 putative PBP binding regions; other site 743720005587 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 743720005588 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 743720005589 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 743720005590 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 743720005591 metal binding site [ion binding]; metal-binding site 743720005592 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 743720005593 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 743720005594 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 743720005595 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 743720005596 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 743720005597 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720005598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720005599 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 743720005600 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 743720005601 active site 743720005602 FMN binding site [chemical binding]; other site 743720005603 2,4-decadienoyl-CoA binding site; other site 743720005604 catalytic residue [active] 743720005605 4Fe-4S cluster binding site [ion binding]; other site 743720005606 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 743720005607 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 743720005608 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 743720005609 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 743720005610 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 743720005611 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 743720005612 active site 743720005613 metal binding site [ion binding]; metal-binding site 743720005614 Rhomboid family; Region: Rhomboid; cl11446 743720005615 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 743720005616 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 743720005617 aminopeptidase N; Provisional; Region: pepN; PRK14015 743720005618 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 743720005619 active site 743720005620 Zn binding site [ion binding]; other site 743720005621 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 743720005622 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 743720005623 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 743720005624 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 743720005625 Immunity protein Imm1; Region: Imm1; pfam14430 743720005626 LysE type translocator; Region: LysE; cl00565 743720005627 Cupin domain; Region: Cupin_2; cl09118 743720005628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720005629 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720005630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720005631 Oxygen tolerance; Region: BatD; pfam13584 743720005632 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 743720005633 metal ion-dependent adhesion site (MIDAS); other site 743720005634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 743720005635 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 743720005636 metal ion-dependent adhesion site (MIDAS); other site 743720005637 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 743720005638 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 743720005639 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 743720005640 MoxR-like ATPases [General function prediction only]; Region: COG0714 743720005641 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720005642 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720005643 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005644 dimer interface [polypeptide binding]; other site 743720005645 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 743720005646 putative CheW interface [polypeptide binding]; other site 743720005647 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 743720005648 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 743720005649 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 743720005650 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 743720005651 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 743720005652 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 743720005653 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 743720005654 quinone interaction residues [chemical binding]; other site 743720005655 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 743720005656 active site 743720005657 catalytic residues [active] 743720005658 FMN binding site [chemical binding]; other site 743720005659 substrate binding site [chemical binding]; other site 743720005660 Ribosome modulation factor; Region: RMF; cl01207 743720005661 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 743720005662 THUMP domain; Region: THUMP; cl12076 743720005663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720005664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720005665 S-adenosylmethionine binding site [chemical binding]; other site 743720005666 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 743720005667 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720005668 Protein with unknown function (DUF469); Region: DUF469; cl01237 743720005669 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 743720005670 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 743720005671 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 743720005672 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 743720005673 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720005674 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 743720005675 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 743720005676 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 743720005677 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743720005678 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 743720005679 Response regulator receiver domain; Region: Response_reg; pfam00072 743720005680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005681 active site 743720005682 phosphorylation site [posttranslational modification] 743720005683 intermolecular recognition site; other site 743720005684 dimerization interface [polypeptide binding]; other site 743720005685 hypothetical protein; Provisional; Region: PRK04860 743720005686 SprT homologues; Region: SprT; cl01182 743720005687 DNA-J related protein; Region: DNAJ_related; pfam12339 743720005688 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 743720005689 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 743720005690 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 743720005691 Ligand Binding Site [chemical binding]; other site 743720005692 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 743720005693 NAD-dependent deacetylase; Provisional; Region: PRK00481 743720005694 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 743720005695 NAD+ binding site [chemical binding]; other site 743720005696 substrate binding site [chemical binding]; other site 743720005697 Zn binding site [ion binding]; other site 743720005698 NlpC/P60 family; Region: NLPC_P60; cl11438 743720005699 NlpC/P60 family; Region: NLPC_P60; cl11438 743720005700 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720005701 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 743720005702 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 743720005703 homodimer interface [polypeptide binding]; other site 743720005704 Walker A motif; other site 743720005705 ATP binding site [chemical binding]; other site 743720005706 hydroxycobalamin binding site [chemical binding]; other site 743720005707 Walker B motif; other site 743720005708 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 743720005709 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720005710 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 743720005711 catalytic triad [active] 743720005712 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 743720005713 putative FMN binding site [chemical binding]; other site 743720005714 CobD/Cbib protein; Region: CobD_Cbib; cl00561 743720005715 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 743720005716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720005717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720005718 homodimer interface [polypeptide binding]; other site 743720005719 catalytic residue [active] 743720005720 cobyric acid synthase; Provisional; Region: PRK00784 743720005721 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720005722 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720005723 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 743720005724 catalytic triad [active] 743720005725 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 743720005726 homotrimer interface [polypeptide binding]; other site 743720005727 Walker A motif; other site 743720005728 GTP binding site [chemical binding]; other site 743720005729 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 743720005730 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 743720005731 putative dimer interface [polypeptide binding]; other site 743720005732 active site pocket [active] 743720005733 putative cataytic base [active] 743720005734 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 743720005735 catalytic core [active] 743720005736 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 743720005737 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 743720005738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005739 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720005740 putative substrate translocation pore; other site 743720005741 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 743720005742 catalytic residues [active] 743720005743 dimer interface [polypeptide binding]; other site 743720005744 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 743720005745 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 743720005746 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 743720005747 dimer interface [polypeptide binding]; other site 743720005748 active site 743720005749 catalytic residue [active] 743720005750 ribonuclease D; Region: rnd; TIGR01388 743720005751 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 743720005752 putative active site [active] 743720005753 catalytic site [active] 743720005754 putative substrate binding site [chemical binding]; other site 743720005755 HRDC domain; Region: HRDC; cl02578 743720005756 YcgL domain; Region: YcgL; cl01189 743720005757 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 743720005758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720005759 Flagellin N-methylase; Region: FliB; cl00497 743720005760 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 743720005761 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 743720005762 hypothetical protein; Provisional; Region: PRK11295 743720005763 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 743720005764 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 743720005765 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720005766 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 743720005767 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 743720005768 putative active site [active] 743720005769 putative dimer interface [polypeptide binding]; other site 743720005770 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 743720005771 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 743720005772 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 743720005773 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 743720005774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720005775 Walker A motif; other site 743720005776 ATP binding site [chemical binding]; other site 743720005777 Walker B motif; other site 743720005778 arginine finger; other site 743720005779 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 743720005780 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 743720005781 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 743720005782 dimer interface [polypeptide binding]; other site 743720005783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720005784 catalytic residue [active] 743720005785 EamA-like transporter family; Region: EamA; cl01037 743720005786 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743720005787 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720005788 N-terminal plug; other site 743720005789 ligand-binding site [chemical binding]; other site 743720005790 PAS domain; Region: PAS_9; pfam13426 743720005791 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720005792 putative active site [active] 743720005793 heme pocket [chemical binding]; other site 743720005794 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720005795 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005796 dimer interface [polypeptide binding]; other site 743720005797 putative CheW interface [polypeptide binding]; other site 743720005798 DTW domain; Region: DTW; cl01221 743720005799 Pirin-related protein [General function prediction only]; Region: COG1741 743720005800 Cupin domain; Region: Cupin_2; cl09118 743720005801 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 743720005802 VacJ like lipoprotein; Region: VacJ; cl01073 743720005803 Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191 743720005804 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 743720005805 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 743720005806 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 743720005807 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 743720005808 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 743720005809 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 743720005810 MgtE intracellular N domain; Region: MgtE_N; cl15244 743720005811 FliG C-terminal domain; Region: FliG_C; pfam01706 743720005812 flagellar assembly protein H; Validated; Region: fliH; PRK05687 743720005813 Flagellar assembly protein FliH; Region: FliH; pfam02108 743720005814 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 743720005815 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 743720005816 Walker A motif/ATP binding site; other site 743720005817 Walker B motif; other site 743720005818 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 743720005819 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 743720005820 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 743720005821 anti sigma factor interaction site; other site 743720005822 regulatory phosphorylation site [posttranslational modification]; other site 743720005823 Response regulator receiver domain; Region: Response_reg; pfam00072 743720005824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005825 active site 743720005826 phosphorylation site [posttranslational modification] 743720005827 intermolecular recognition site; other site 743720005828 dimerization interface [polypeptide binding]; other site 743720005829 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 743720005830 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 743720005831 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 743720005832 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 743720005833 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 743720005834 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 743720005835 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 743720005836 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 743720005837 flagellar motor switch protein; Validated; Region: fliN; PRK05698 743720005838 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 743720005839 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 743720005840 FliP family; Region: FliP; cl00593 743720005841 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 743720005842 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 743720005843 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 743720005844 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 743720005845 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 743720005846 P-class dimer interface [polypeptide binding]; other site 743720005847 active site 743720005848 Cu2+ binding site [ion binding]; other site 743720005849 E-class dimer interface [polypeptide binding]; other site 743720005850 Zn2+ binding site [ion binding]; other site 743720005851 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 743720005852 FHIPEP family; Region: FHIPEP; pfam00771 743720005853 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 743720005854 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720005855 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 743720005856 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720005857 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 743720005858 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 743720005859 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720005860 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 743720005861 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720005862 DNA binding residues [nucleotide binding] 743720005863 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 743720005864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005865 active site 743720005866 phosphorylation site [posttranslational modification] 743720005867 intermolecular recognition site; other site 743720005868 dimerization interface [polypeptide binding]; other site 743720005869 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 743720005870 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720005871 putative binding surface; other site 743720005872 active site 743720005873 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 743720005874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005875 ATP binding site [chemical binding]; other site 743720005876 Mg2+ binding site [ion binding]; other site 743720005877 G-X-G motif; other site 743720005878 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 743720005879 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 743720005880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005881 active site 743720005882 phosphorylation site [posttranslational modification] 743720005883 intermolecular recognition site; other site 743720005884 dimerization interface [polypeptide binding]; other site 743720005885 CheB methylesterase; Region: CheB_methylest; pfam01339 743720005886 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 743720005887 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 743720005888 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 743720005889 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720005890 ligand binding site [chemical binding]; other site 743720005891 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 743720005892 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743720005893 P-loop; other site 743720005894 Magnesium ion binding site [ion binding]; other site 743720005895 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743720005896 Magnesium ion binding site [ion binding]; other site 743720005897 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 743720005898 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 743720005899 putative CheA interaction surface; other site 743720005900 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 743720005901 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 743720005902 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 743720005903 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 743720005904 CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE...; Region: ABC_CcmA_heme_exporter; cd03231 743720005905 Walker A/P-loop; other site 743720005906 ATP binding site [chemical binding]; other site 743720005907 Q-loop/lid; other site 743720005908 ABC transporter signature motif; other site 743720005909 Walker B; other site 743720005910 D-loop; other site 743720005911 H-loop/switch region; other site 743720005912 CcmB protein; Region: CcmB; cl01016 743720005913 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 743720005914 Heme exporter protein D (CcmD); Region: CcmD; cl11475 743720005915 CcmE; Region: CcmE; cl00994 743720005916 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 743720005917 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 743720005918 catalytic residues [active] 743720005919 central insert; other site 743720005920 Cytochrome C biogenesis protein; Region: CcmH; cl01179 743720005921 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 743720005922 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 743720005923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 743720005924 binding surface 743720005925 TPR motif; other site 743720005926 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 743720005927 Helix-turn-helix domains; Region: HTH; cl00088 743720005928 Bacterial transcriptional regulator; Region: IclR; pfam01614 743720005929 short chain dehydrogenase; Provisional; Region: PRK05650 743720005930 classical (c) SDRs; Region: SDR_c; cd05233 743720005931 NAD(P) binding site [chemical binding]; other site 743720005932 active site 743720005933 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 743720005934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005935 putative substrate translocation pore; other site 743720005936 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 743720005937 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743720005938 IHF dimer interface [polypeptide binding]; other site 743720005939 IHF - DNA interface [nucleotide binding]; other site 743720005940 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720005941 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720005942 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720005943 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005944 dimer interface [polypeptide binding]; other site 743720005945 putative CheW interface [polypeptide binding]; other site 743720005946 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 743720005947 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 743720005948 putative oligomer interface [polypeptide binding]; other site 743720005949 putative active site [active] 743720005950 metal binding site [ion binding]; metal-binding site 743720005951 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 743720005952 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720005953 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720005954 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 743720005955 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 743720005956 active site 743720005957 dimer interface [polypeptide binding]; other site 743720005958 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 743720005959 Ligand Binding Site [chemical binding]; other site 743720005960 Molecular Tunnel; other site 743720005961 Transposase IS200 like; Region: Y1_Tnp; cl00848 743720005962 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 743720005963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 743720005964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720005965 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 743720005966 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 743720005967 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 743720005968 Protein of unknown function (DUF454); Region: DUF454; cl01063 743720005969 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 743720005970 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 743720005971 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720005972 ATP binding site [chemical binding]; other site 743720005973 putative Mg++ binding site [ion binding]; other site 743720005974 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720005975 nucleotide binding region [chemical binding]; other site 743720005976 ATP-binding site [chemical binding]; other site 743720005977 RQC domain; Region: RQC; cl09632 743720005978 HRDC domain; Region: HRDC; cl02578 743720005979 transcriptional regulator SlyA; Provisional; Region: PRK03573 743720005980 Helix-turn-helix domains; Region: HTH; cl00088 743720005981 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 743720005982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005983 putative substrate translocation pore; other site 743720005984 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 743720005985 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 743720005986 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 743720005987 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 743720005988 Rdx family; Region: Rdx; cl01407 743720005989 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 743720005990 dimer interface [polypeptide binding]; other site 743720005991 putative tRNA-binding site [nucleotide binding]; other site 743720005992 Cupin domain; Region: Cupin_2; cl09118 743720005993 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720005994 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720005995 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720005996 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743720005997 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 743720005998 putative active site [active] 743720005999 putative metal binding site [ion binding]; other site 743720006000 MASE2 domain; Region: MASE2; pfam05230 743720006001 Chordopoxvirus G3 protein; Region: Chordopox_G3; pfam06129 743720006002 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 743720006003 cyclase homology domain; Region: CHD; cd07302 743720006004 nucleotidyl binding site; other site 743720006005 metal binding site [ion binding]; metal-binding site 743720006006 dimer interface [polypeptide binding]; other site 743720006007 Protein of unknown function (DUF962); Region: DUF962; cl01879 743720006008 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 743720006009 Cation transport protein; Region: TrkH; cl10514 743720006010 Flagellin N-methylase; Region: FliB; cl00497 743720006011 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 743720006012 putative FMN binding site [chemical binding]; other site 743720006013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720006014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 743720006015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720006016 ATP binding site [chemical binding]; other site 743720006017 G-X-G motif; other site 743720006018 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 743720006019 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 743720006020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006021 active site 743720006022 phosphorylation site [posttranslational modification] 743720006023 intermolecular recognition site; other site 743720006024 dimerization interface [polypeptide binding]; other site 743720006025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720006026 DNA binding site [nucleotide binding] 743720006027 YCII-related domain; Region: YCII; cl00999 743720006028 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 743720006029 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743720006030 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 743720006031 ScpA/B protein; Region: ScpA_ScpB; cl00598 743720006032 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 743720006033 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 743720006034 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 743720006035 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720006036 RNA binding surface [nucleotide binding]; other site 743720006037 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 743720006038 probable active site [active] 743720006039 transcription termination factor Rho; Provisional; Region: PRK12678 743720006040 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720006041 metal binding site [ion binding]; metal-binding site 743720006042 active site 743720006043 I-site; other site 743720006044 short chain dehydrogenase; Provisional; Region: PRK08703 743720006045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720006046 NAD(P) binding site [chemical binding]; other site 743720006047 active site 743720006048 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 743720006049 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720006050 phosphoglycolate phosphatase; Provisional; Region: PRK13222 743720006051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720006052 motif II; other site 743720006053 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 743720006054 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 743720006055 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720006056 catalytic residue [active] 743720006057 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 743720006058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720006059 S-adenosylmethionine binding site [chemical binding]; other site 743720006060 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 743720006061 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 743720006062 active site 743720006063 putative substrate binding pocket [chemical binding]; other site 743720006064 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 743720006065 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 743720006066 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 743720006067 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 743720006068 CAP-like domain; other site 743720006069 active site 743720006070 primary dimer interface [polypeptide binding]; other site 743720006071 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743720006072 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743720006073 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743720006074 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743720006075 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743720006076 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 743720006077 homodimer interface [polypeptide binding]; other site 743720006078 substrate-cofactor binding pocket; other site 743720006079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720006080 catalytic residue [active] 743720006081 Chorismate mutase type II; Region: CM_2; cl00693 743720006082 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 743720006083 Prephenate dehydratase; Region: PDT; pfam00800 743720006084 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 743720006085 putative L-Phe binding site [chemical binding]; other site 743720006086 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 743720006087 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720006088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720006089 homodimer interface [polypeptide binding]; other site 743720006090 catalytic residue [active] 743720006091 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 743720006092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720006093 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 743720006094 hinge; other site 743720006095 active site 743720006096 cytidylate kinase; Provisional; Region: cmk; PRK00023 743720006097 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 743720006098 CMP-binding site; other site 743720006099 The sites determining sugar specificity; other site 743720006100 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 743720006101 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 743720006102 RNA binding site [nucleotide binding]; other site 743720006103 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 743720006104 RNA binding site [nucleotide binding]; other site 743720006105 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 743720006106 RNA binding site [nucleotide binding]; other site 743720006107 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743720006108 RNA binding site [nucleotide binding]; other site 743720006109 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743720006110 RNA binding site [nucleotide binding]; other site 743720006111 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 743720006112 RNA binding site [nucleotide binding]; other site 743720006113 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 743720006114 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 743720006115 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 743720006116 putative alpha subunit interface [polypeptide binding]; other site 743720006117 putative active site [active] 743720006118 putative substrate binding site [chemical binding]; other site 743720006119 Fe binding site [ion binding]; other site 743720006120 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 743720006121 inter-subunit interface; other site 743720006122 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 743720006123 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720006124 catalytic loop [active] 743720006125 iron binding site [ion binding]; other site 743720006126 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 743720006127 FAD binding pocket [chemical binding]; other site 743720006128 FAD binding motif [chemical binding]; other site 743720006129 phosphate binding motif [ion binding]; other site 743720006130 beta-alpha-beta structure motif; other site 743720006131 NAD binding pocket [chemical binding]; other site 743720006132 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720006133 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 743720006134 putative NAD(P) binding site [chemical binding]; other site 743720006135 active site 743720006136 benzoate transport; Region: 2A0115; TIGR00895 743720006137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006138 putative substrate translocation pore; other site 743720006139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006140 Benzoate membrane transport protein; Region: BenE; pfam03594 743720006141 benzoate transporter; Region: benE; TIGR00843 743720006142 outer membrane porin, OprD family; Region: OprD; pfam03573 743720006143 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 743720006144 Helix-turn-helix domains; Region: HTH; cl00088 743720006145 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720006146 dimerization interface [polypeptide binding]; other site 743720006147 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 743720006148 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 743720006149 octamer interface [polypeptide binding]; other site 743720006150 active site 743720006151 Muconolactone delta-isomerase; Region: MIase; cl01992 743720006152 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 743720006153 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 743720006154 dimer interface [polypeptide binding]; other site 743720006155 active site 743720006156 Cupin domain; Region: Cupin_2; cl09118 743720006157 Helix-turn-helix domain; Region: HTH_18; pfam12833 743720006158 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 743720006159 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 743720006160 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 743720006161 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720006162 dimer interface [polypeptide binding]; other site 743720006163 active site 743720006164 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 743720006165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006166 putative substrate translocation pore; other site 743720006167 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 743720006168 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 743720006169 tetramer interface [polypeptide binding]; other site 743720006170 active site 743720006171 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 743720006172 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 743720006173 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720006174 dimerization interface [polypeptide binding]; other site 743720006175 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720006176 dimer interface [polypeptide binding]; other site 743720006177 putative CheW interface [polypeptide binding]; other site 743720006178 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 743720006179 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720006180 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 743720006181 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720006182 NAD(P) binding site [chemical binding]; other site 743720006183 catalytic residues [active] 743720006184 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 743720006185 active site 743720006186 metal binding site [ion binding]; metal-binding site 743720006187 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720006188 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 743720006189 active site 743720006190 metal binding site [ion binding]; metal-binding site 743720006191 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 743720006192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720006193 Transcriptional regulator [Transcription]; Region: IclR; COG1414 743720006194 Helix-turn-helix domains; Region: HTH; cl00088 743720006195 Bacterial transcriptional regulator; Region: IclR; pfam01614 743720006196 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 743720006197 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 743720006198 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 743720006199 benzoate transport; Region: 2A0115; TIGR00895 743720006200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006201 putative substrate translocation pore; other site 743720006202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006203 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 743720006204 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720006205 NAD(P) binding site [chemical binding]; other site 743720006206 catalytic residues [active] 743720006207 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 743720006208 Fusaric acid resistance protein family; Region: FUSC; pfam04632 743720006209 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 743720006210 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 743720006211 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 743720006212 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 743720006213 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 743720006214 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720006215 Walker A/P-loop; other site 743720006216 ATP binding site [chemical binding]; other site 743720006217 Q-loop/lid; other site 743720006218 ABC transporter signature motif; other site 743720006219 Walker B; other site 743720006220 D-loop; other site 743720006221 H-loop/switch region; other site 743720006222 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 743720006223 homodecamer interface [polypeptide binding]; other site 743720006224 GTP cyclohydrolase I; Provisional; Region: PLN03044 743720006225 active site 743720006226 putative catalytic site residues [active] 743720006227 zinc binding site [ion binding]; other site 743720006228 GTP-CH-I/GFRP interaction surface; other site 743720006229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720006230 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 743720006231 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 743720006232 Dehydratase family; Region: ILVD_EDD; cl00340 743720006233 6-phosphogluconate dehydratase; Region: edd; TIGR01196 743720006234 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 743720006235 glucokinase, proteobacterial type; Region: glk; TIGR00749 743720006236 osmolarity response regulator; Provisional; Region: ompR; PRK09468 743720006237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006238 active site 743720006239 phosphorylation site [posttranslational modification] 743720006240 intermolecular recognition site; other site 743720006241 dimerization interface [polypeptide binding]; other site 743720006242 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720006243 DNA binding site [nucleotide binding] 743720006244 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 743720006245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720006246 ATP binding site [chemical binding]; other site 743720006247 Mg2+ binding site [ion binding]; other site 743720006248 G-X-G motif; other site 743720006249 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 743720006250 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 743720006251 dimerization interface [polypeptide binding]; other site 743720006252 putative active cleft [active] 743720006253 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 743720006254 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720006255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720006256 dimer interface [polypeptide binding]; other site 743720006257 conserved gate region; other site 743720006258 putative PBP binding loops; other site 743720006259 ABC-ATPase subunit interface; other site 743720006260 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 743720006261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720006262 dimer interface [polypeptide binding]; other site 743720006263 conserved gate region; other site 743720006264 putative PBP binding loops; other site 743720006265 ABC-ATPase subunit interface; other site 743720006266 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 743720006267 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 743720006268 Walker A/P-loop; other site 743720006269 ATP binding site [chemical binding]; other site 743720006270 Q-loop/lid; other site 743720006271 ABC transporter signature motif; other site 743720006272 Walker B; other site 743720006273 D-loop; other site 743720006274 H-loop/switch region; other site 743720006275 TOBE domain; Region: TOBE_2; cl01440 743720006276 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 743720006277 trimer interface; other site 743720006278 sugar binding site [chemical binding]; other site 743720006279 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 743720006280 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 743720006281 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 743720006282 putative active site [active] 743720006283 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 743720006284 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 743720006285 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 743720006286 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 743720006287 putative active site [active] 743720006288 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 743720006289 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 743720006290 active site 743720006291 intersubunit interface [polypeptide binding]; other site 743720006292 catalytic residue [active] 743720006293 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 743720006294 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 743720006295 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 743720006296 shikimate binding site; other site 743720006297 NAD(P) binding site [chemical binding]; other site 743720006298 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 743720006299 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 743720006300 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 743720006301 ATP-dependent DNA ligase; Validated; Region: PRK09247 743720006302 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 743720006303 active site 743720006304 DNA binding site [nucleotide binding] 743720006305 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 743720006306 DNA binding site [nucleotide binding] 743720006307 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 743720006308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720006309 ATP binding site [chemical binding]; other site 743720006310 putative Mg++ binding site [ion binding]; other site 743720006311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720006312 nucleotide binding region [chemical binding]; other site 743720006313 ATP-binding site [chemical binding]; other site 743720006314 DEAD/H associated; Region: DEAD_assoc; pfam08494 743720006315 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 743720006316 putative active site [active] 743720006317 putative metal binding site [ion binding]; other site 743720006318 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720006319 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720006320 dimerization interface [polypeptide binding]; other site 743720006321 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720006322 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720006323 dimer interface [polypeptide binding]; other site 743720006324 putative CheW interface [polypeptide binding]; other site 743720006325 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720006326 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 743720006327 Tetramer interface [polypeptide binding]; other site 743720006328 active site 743720006329 FMN-binding site [chemical binding]; other site 743720006330 phenyl proprionate permease family protein; Region: 2A0127; TIGR00902 743720006331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006332 putative substrate translocation pore; other site 743720006333 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 743720006334 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 743720006335 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 743720006336 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 743720006337 DNA binding site [nucleotide binding] 743720006338 active site 743720006339 AlkA N-terminal domain; Region: AlkA_N; cl05528 743720006340 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 743720006341 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743720006342 minor groove reading motif; other site 743720006343 helix-hairpin-helix signature motif; other site 743720006344 substrate binding pocket [chemical binding]; other site 743720006345 active site 743720006346 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 743720006347 Sulfatase; Region: Sulfatase; cl10460 743720006348 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 743720006349 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 743720006350 active site 743720006351 Zn binding site [ion binding]; other site 743720006352 Uncharacterized conserved protein [Function unknown]; Region: COG2308 743720006353 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 743720006354 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 743720006355 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 743720006356 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 743720006357 Membrane transport protein; Region: Mem_trans; cl09117 743720006358 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 743720006359 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 743720006360 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 743720006361 catalytic triad [active] 743720006362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720006363 Predicted dehydrogenase [General function prediction only]; Region: COG0579 743720006364 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 743720006365 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720006366 NAD(P) binding site [chemical binding]; other site 743720006367 catalytic residues [active] 743720006368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720006369 Helix-turn-helix domains; Region: HTH; cl00088 743720006370 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720006371 putative effector binding pocket; other site 743720006372 dimerization interface [polypeptide binding]; other site 743720006373 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 743720006374 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 743720006375 active site 743720006376 dimer interface [polypeptide binding]; other site 743720006377 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 743720006378 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 743720006379 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 743720006380 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 743720006381 VacJ like lipoprotein; Region: VacJ; cl01073 743720006382 PilZ domain; Region: PilZ; cl01260 743720006383 Response regulator receiver domain; Region: Response_reg; pfam00072 743720006384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006385 active site 743720006386 phosphorylation site [posttranslational modification] 743720006387 intermolecular recognition site; other site 743720006388 dimerization interface [polypeptide binding]; other site 743720006389 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 743720006390 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 743720006391 anti sigma factor interaction site; other site 743720006392 regulatory phosphorylation site [posttranslational modification]; other site 743720006393 transaldolase-like protein; Provisional; Region: PTZ00411 743720006394 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 743720006395 active site 743720006396 dimer interface [polypeptide binding]; other site 743720006397 catalytic residue [active] 743720006398 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 743720006399 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 743720006400 FMN binding site [chemical binding]; other site 743720006401 active site 743720006402 catalytic residues [active] 743720006403 substrate binding site [chemical binding]; other site 743720006404 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743720006405 DNA binding site [nucleotide binding] 743720006406 Int/Topo IB signature motif; other site 743720006407 active site 743720006408 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 743720006409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 743720006410 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 743720006411 Protein of unknown function (DUF2274); Region: DUF2274; cl02406 743720006412 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 743720006413 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 743720006414 VirB7 interaction site; other site 743720006415 VirB8 protein; Region: VirB8; cl01500 743720006416 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 743720006417 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193 743720006418 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 743720006419 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 743720006420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720006421 Walker A motif; other site 743720006422 ATP binding site [chemical binding]; other site 743720006423 Walker B motif; other site 743720006424 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720006425 Walker B; other site 743720006426 D-loop; other site 743720006427 H-loop/switch region; other site 743720006428 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 743720006429 TrbC/VIRB2 family; Region: TrbC; cl01583 743720006430 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 743720006431 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 743720006432 ATP binding site [chemical binding]; other site 743720006433 Walker A motif; other site 743720006434 hexamer interface [polypeptide binding]; other site 743720006435 Walker B motif; other site 743720006436 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 743720006437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720006438 Walker A motif; other site 743720006439 ATP binding site [chemical binding]; other site 743720006440 Walker B motif; other site 743720006441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720006442 Helix-turn-helix domains; Region: HTH; cl00088 743720006443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720006444 dimerization interface [polypeptide binding]; other site 743720006445 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 743720006446 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 743720006447 Helix-turn-helix domains; Region: HTH; cl00088 743720006448 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 743720006449 dimerization interface [polypeptide binding]; other site 743720006450 substrate binding pocket [chemical binding]; other site 743720006451 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 743720006452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 743720006453 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 743720006454 active site 743720006455 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 743720006456 dimer interface [polypeptide binding]; other site 743720006457 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 743720006458 Ligand Binding Site [chemical binding]; other site 743720006459 Molecular Tunnel; other site 743720006460 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 743720006461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720006462 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 743720006463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720006464 Coenzyme A binding pocket [chemical binding]; other site 743720006465 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 743720006466 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 743720006467 substrate-cofactor binding pocket; other site 743720006468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720006469 catalytic residue [active] 743720006470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 743720006471 phosphoethanolamine N-methyltransferase; Region: PLN02336 743720006472 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 743720006473 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 743720006474 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 743720006475 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 743720006476 ParA-like protein; Provisional; Region: PHA02518 743720006477 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743720006478 P-loop; other site 743720006479 Magnesium ion binding site [ion binding]; other site 743720006480 Replication initiator protein A; Region: RPA; cl02339 743720006481 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 743720006482 Global regulator protein family; Region: CsrA; cl00670 743720006483 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720006484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720006485 Coenzyme A binding pocket [chemical binding]; other site 743720006486 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720006487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720006488 DNA-binding site [nucleotide binding]; DNA binding site 743720006489 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720006490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720006491 homodimer interface [polypeptide binding]; other site 743720006492 catalytic residue [active] 743720006493 benzoate transporter; Region: benE; TIGR00843 743720006494 Benzoate membrane transport protein; Region: BenE; pfam03594 743720006495 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 743720006496 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720006497 catalytic residue [active] 743720006498 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 743720006499 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 743720006500 dimer interface [polypeptide binding]; other site 743720006501 glycine-pyridoxal phosphate binding site [chemical binding]; other site 743720006502 active site 743720006503 folate binding site [chemical binding]; other site 743720006504 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 743720006505 putative metal binding site [ion binding]; other site 743720006506 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 743720006507 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 743720006508 MPN+ (JAMM) motif; other site 743720006509 Zinc-binding site [ion binding]; other site 743720006510 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 743720006511 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743720006512 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720006513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720006514 Helix-turn-helix domains; Region: HTH; cl00088 743720006515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 743720006516 RNA polymerase sigma factor; Provisional; Region: PRK12528 743720006517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720006518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 743720006519 fec operon regulator FecR; Reviewed; Region: PRK09774 743720006520 FecR protein; Region: FecR; pfam04773 743720006521 Secretin and TonB N terminus short domain; Region: STN; cl06624 743720006522 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 743720006523 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720006524 N-terminal plug; other site 743720006525 ligand-binding site [chemical binding]; other site 743720006526 LysR family transcriptional regulator; Provisional; Region: PRK14997 743720006527 Helix-turn-helix domains; Region: HTH; cl00088 743720006528 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720006529 dimerization interface [polypeptide binding]; other site 743720006530 putative effector binding pocket; other site 743720006531 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 743720006532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720006533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 743720006534 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 743720006535 His-Xaa-Ser system radical SAM maturase HsxC; Region: rSAM_paired_2; TIGR03977 743720006536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720006537 FeS/SAM binding site; other site 743720006538 His-Xaa-Ser system radical SAM maturase HsxB; Region: rSAM_paired_1; TIGR03978 743720006539 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720006540 FeS/SAM binding site; other site 743720006541 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 743720006542 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 743720006543 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720006544 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 743720006545 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720006546 Family description; Region: UvrD_C_2; cl15862 743720006547 haemagglutination activity domain; Region: Haemagg_act; cl05436 743720006548 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 743720006549 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 743720006550 Surface antigen; Region: Bac_surface_Ag; cl03097 743720006551 Arc-like DNA binding domain; Region: Arc; pfam03869 743720006552 DNA-specific endonuclease I; Provisional; Region: PRK15137 743720006553 Endonuclease I; Region: Endonuclease_1; cl01003 743720006554 Nitrate and nitrite sensing; Region: NIT; pfam08376 743720006555 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720006556 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720006557 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720006558 dimer interface [polypeptide binding]; other site 743720006559 putative CheW interface [polypeptide binding]; other site 743720006560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720006561 PAS domain; Region: PAS_9; pfam13426 743720006562 putative active site [active] 743720006563 heme pocket [chemical binding]; other site 743720006564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720006565 PAS fold; Region: PAS_3; pfam08447 743720006566 putative active site [active] 743720006567 heme pocket [chemical binding]; other site 743720006568 hypothetical protein; Provisional; Region: PRK13560 743720006569 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 743720006570 sensory histidine kinase AtoS; Provisional; Region: PRK11360 743720006571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720006572 ATP binding site [chemical binding]; other site 743720006573 Mg2+ binding site [ion binding]; other site 743720006574 G-X-G motif; other site 743720006575 Response regulator receiver domain; Region: Response_reg; pfam00072 743720006576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006577 active site 743720006578 phosphorylation site [posttranslational modification] 743720006579 intermolecular recognition site; other site 743720006580 dimerization interface [polypeptide binding]; other site 743720006581 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 743720006582 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720006583 ligand binding site [chemical binding]; other site 743720006584 flexible hinge region; other site 743720006585 Helix-turn-helix domains; Region: HTH; cl00088 743720006586 CsbD-like; Region: CsbD; cl15799 743720006587 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 743720006588 Putative glucoamylase; Region: Glycoamylase; pfam10091 743720006589 Putative carbohydrate binding domain; Region: CBM_X; cl05621 743720006590 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 743720006591 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 743720006592 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 743720006593 Putative carbohydrate binding domain; Region: CBM_X; cl05621 743720006594 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 743720006595 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 743720006596 Response regulator receiver domain; Region: Response_reg; pfam00072 743720006597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006598 active site 743720006599 phosphorylation site [posttranslational modification] 743720006600 intermolecular recognition site; other site 743720006601 dimerization interface [polypeptide binding]; other site 743720006602 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720006603 Zn2+ binding site [ion binding]; other site 743720006604 Mg2+ binding site [ion binding]; other site 743720006605 AAA domain; Region: AAA_33; pfam13671 743720006606 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720006607 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 743720006608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720006609 DNA-binding site [nucleotide binding]; DNA binding site 743720006610 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 743720006611 UTRA domain; Region: UTRA; cl01230 743720006612 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 743720006613 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 743720006614 active site turn [active] 743720006615 phosphorylation site [posttranslational modification] 743720006616 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 743720006617 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 743720006618 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 743720006619 Ca binding site [ion binding]; other site 743720006620 active site 743720006621 catalytic site [active] 743720006622 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 743720006623 HPr interaction site; other site 743720006624 glycerol kinase (GK) interaction site [polypeptide binding]; other site 743720006625 active site 743720006626 phosphorylation site [posttranslational modification] 743720006627 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 743720006628 dimerization domain swap beta strand [polypeptide binding]; other site 743720006629 regulatory protein interface [polypeptide binding]; other site 743720006630 active site 743720006631 regulatory phosphorylation site [posttranslational modification]; other site 743720006632 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 743720006633 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 743720006634 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 743720006635 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 743720006636 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 743720006637 active site turn [active] 743720006638 phosphorylation site [posttranslational modification] 743720006639 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 743720006640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720006641 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 743720006642 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720006643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720006644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006645 D-galactonate transporter; Region: 2A0114; TIGR00893 743720006646 putative substrate translocation pore; other site 743720006647 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 743720006648 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 743720006649 classical (c) SDRs; Region: SDR_c; cd05233 743720006650 NAD(P) binding site [chemical binding]; other site 743720006651 active site 743720006652 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 743720006653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720006654 Domain of unknown function DUF; Region: DUF204; pfam02659 743720006655 Domain of unknown function DUF; Region: DUF204; pfam02659 743720006656 YhhN-like protein; Region: YhhN; cl01505 743720006657 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 743720006658 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 743720006659 Trp docking motif [polypeptide binding]; other site 743720006660 putative active site [active] 743720006661 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 743720006662 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 743720006663 putative ligand binding residues [chemical binding]; other site 743720006664 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 743720006665 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720006666 dimer interface [polypeptide binding]; other site 743720006667 putative PBP binding regions; other site 743720006668 ABC-ATPase subunit interface; other site 743720006669 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 743720006670 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 743720006671 Walker A/P-loop; other site 743720006672 ATP binding site [chemical binding]; other site 743720006673 Q-loop/lid; other site 743720006674 ABC transporter signature motif; other site 743720006675 Walker B; other site 743720006676 D-loop; other site 743720006677 H-loop/switch region; other site 743720006678 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 743720006679 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720006680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006681 outer membrane porin, OprD family; Region: OprD; pfam03573 743720006682 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743720006683 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 743720006684 Prostaglandin dehydrogenases; Region: PGDH; cd05288 743720006685 NAD(P) binding site [chemical binding]; other site 743720006686 substrate binding site [chemical binding]; other site 743720006687 dimer interface [polypeptide binding]; other site 743720006688 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 743720006689 Membrane transport protein; Region: Mem_trans; cl09117 743720006690 benzoate transporter; Region: benE; TIGR00843 743720006691 Benzoate membrane transport protein; Region: BenE; pfam03594 743720006692 LysE type translocator; Region: LysE; cl00565 743720006693 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 743720006694 Helix-turn-helix domains; Region: HTH; cl00088 743720006695 aspartate aminotransferase; Provisional; Region: PRK05764 743720006696 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720006697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720006698 homodimer interface [polypeptide binding]; other site 743720006699 catalytic residue [active] 743720006700 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720006701 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 743720006702 putative C-terminal domain interface [polypeptide binding]; other site 743720006703 putative GSH binding site (G-site) [chemical binding]; other site 743720006704 putative dimer interface [polypeptide binding]; other site 743720006705 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 743720006706 N-terminal domain interface [polypeptide binding]; other site 743720006707 dimer interface [polypeptide binding]; other site 743720006708 substrate binding pocket (H-site) [chemical binding]; other site 743720006709 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 743720006710 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 743720006711 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743720006712 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 743720006713 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 743720006714 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 743720006715 DNA binding residues [nucleotide binding] 743720006716 dimer interface [polypeptide binding]; other site 743720006717 putative metal binding site [ion binding]; other site 743720006718 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 743720006719 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743720006720 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 743720006721 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 743720006722 universal stress protein UspE; Provisional; Region: PRK11175 743720006723 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720006724 Ligand Binding Site [chemical binding]; other site 743720006725 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 743720006726 active site 743720006727 dinuclear metal binding site [ion binding]; other site 743720006728 dimerization interface [polypeptide binding]; other site 743720006729 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743720006730 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 743720006731 putative active site [active] 743720006732 putative metal binding site [ion binding]; other site 743720006733 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 743720006734 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 743720006735 substrate binding site [chemical binding]; other site 743720006736 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 743720006737 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743720006738 active site 743720006739 HIGH motif; other site 743720006740 nucleotide binding site [chemical binding]; other site 743720006741 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 743720006742 KMSKS motif; other site 743720006743 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 743720006744 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 743720006745 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 743720006746 active site 743720006747 HIGH motif; other site 743720006748 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 743720006749 KMSKS motif; other site 743720006750 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 743720006751 tRNA binding surface [nucleotide binding]; other site 743720006752 anticodon binding site; other site 743720006753 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 743720006754 Family description; Region: UvrD_C_2; cl15862 743720006755 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 743720006756 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 743720006757 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 743720006758 homodimer interface [polypeptide binding]; other site 743720006759 NADP binding site [chemical binding]; other site 743720006760 substrate binding site [chemical binding]; other site 743720006761 trigger factor; Provisional; Region: tig; PRK01490 743720006762 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 743720006763 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 743720006764 Clp protease; Region: CLP_protease; pfam00574 743720006765 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 743720006766 oligomer interface [polypeptide binding]; other site 743720006767 active site residues [active] 743720006768 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 743720006769 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 743720006770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720006771 Walker A motif; other site 743720006772 ATP binding site [chemical binding]; other site 743720006773 Walker B motif; other site 743720006774 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 743720006775 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 743720006776 Found in ATP-dependent protease La (LON); Region: LON; smart00464 743720006777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720006778 Walker A motif; other site 743720006779 ATP binding site [chemical binding]; other site 743720006780 Walker B motif; other site 743720006781 arginine finger; other site 743720006782 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 743720006783 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743720006784 IHF dimer interface [polypeptide binding]; other site 743720006785 IHF - DNA interface [nucleotide binding]; other site 743720006786 periplasmic folding chaperone; Provisional; Region: PRK10788 743720006787 SurA N-terminal domain; Region: SurA_N_3; cl07813 743720006788 PPIC-type PPIASE domain; Region: Rotamase; cl08278 743720006789 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 743720006790 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 743720006791 Walker A/P-loop; other site 743720006792 ATP binding site [chemical binding]; other site 743720006793 Q-loop/lid; other site 743720006794 ABC transporter signature motif; other site 743720006795 Walker B; other site 743720006796 D-loop; other site 743720006797 H-loop/switch region; other site 743720006798 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720006799 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 743720006800 Walker A/P-loop; other site 743720006801 ATP binding site [chemical binding]; other site 743720006802 Q-loop/lid; other site 743720006803 ABC transporter signature motif; other site 743720006804 Walker B; other site 743720006805 D-loop; other site 743720006806 H-loop/switch region; other site 743720006807 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720006808 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 743720006809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720006810 dimer interface [polypeptide binding]; other site 743720006811 conserved gate region; other site 743720006812 putative PBP binding loops; other site 743720006813 ABC-ATPase subunit interface; other site 743720006814 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 743720006815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720006816 dimer interface [polypeptide binding]; other site 743720006817 conserved gate region; other site 743720006818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743720006819 ABC-ATPase subunit interface; other site 743720006820 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 743720006821 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 743720006822 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 743720006823 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 743720006824 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 743720006825 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 743720006826 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720006827 catalytic residue [active] 743720006828 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 743720006829 putative peptidoglycan binding site; other site 743720006830 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 743720006831 putative peptidoglycan binding site; other site 743720006832 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 743720006833 putative peptidoglycan binding site; other site 743720006834 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 743720006835 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 743720006836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720006837 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 743720006838 RNA/DNA hybrid binding site [nucleotide binding]; other site 743720006839 active site 743720006840 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 743720006841 active site 743720006842 substrate binding site [chemical binding]; other site 743720006843 catalytic site [active] 743720006844 arginine decarboxylase; Provisional; Region: PRK15029 743720006845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 743720006846 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 743720006847 homodimer interface [polypeptide binding]; other site 743720006848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720006849 catalytic residue [active] 743720006850 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 743720006851 enoyl-CoA hydratase; Provisional; Region: PRK06142 743720006852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720006853 substrate binding site [chemical binding]; other site 743720006854 oxyanion hole (OAH) forming residues; other site 743720006855 trimer interface [polypeptide binding]; other site 743720006856 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 743720006857 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 743720006858 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 743720006859 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 743720006860 putative NADH binding site [chemical binding]; other site 743720006861 putative active site [active] 743720006862 nudix motif; other site 743720006863 putative metal binding site [ion binding]; other site 743720006864 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 743720006865 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 743720006866 classical (c) SDRs; Region: SDR_c; cd05233 743720006867 NAD(P) binding site [chemical binding]; other site 743720006868 active site 743720006869 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 743720006870 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 743720006871 putative active site [active] 743720006872 putative substrate binding site [chemical binding]; other site 743720006873 ATP binding site [chemical binding]; other site 743720006874 SCP-2 sterol transfer family; Region: SCP2; cl01225 743720006875 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 743720006876 catalytic core [active] 743720006877 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 743720006878 putative inner membrane peptidase; Provisional; Region: PRK11778 743720006879 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 743720006880 tandem repeat interface [polypeptide binding]; other site 743720006881 oligomer interface [polypeptide binding]; other site 743720006882 active site residues [active] 743720006883 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 743720006884 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 743720006885 NADP binding site [chemical binding]; other site 743720006886 dimer interface [polypeptide binding]; other site 743720006887 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 743720006888 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 743720006889 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720006890 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720006891 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 743720006892 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 743720006893 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720006894 substrate binding pocket [chemical binding]; other site 743720006895 membrane-bound complex binding site; other site 743720006896 hinge residues; other site 743720006897 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 743720006898 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 743720006899 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 743720006900 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 743720006901 substrate binding pocket [chemical binding]; other site 743720006902 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 743720006903 B12 binding site [chemical binding]; other site 743720006904 cobalt ligand [ion binding]; other site 743720006905 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 743720006906 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 743720006907 OpgC protein; Region: OpgC_C; cl00792 743720006908 Acyltransferase family; Region: Acyl_transf_3; pfam01757 743720006909 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 743720006910 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 743720006911 NifU-like domain; Region: NifU; cl00484 743720006912 Response regulator receiver domain; Region: Response_reg; pfam00072 743720006913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006914 active site 743720006915 phosphorylation site [posttranslational modification] 743720006916 intermolecular recognition site; other site 743720006917 dimerization interface [polypeptide binding]; other site 743720006918 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 743720006919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720006920 PAS fold; Region: PAS; pfam00989 743720006921 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720006922 metal binding site [ion binding]; metal-binding site 743720006923 active site 743720006924 I-site; other site 743720006925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 743720006926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 743720006927 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 743720006928 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720006929 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 743720006930 conserved cys residue [active] 743720006931 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 743720006932 DNA binding site [nucleotide binding] 743720006933 active site 743720006934 Int/Topo IB signature motif; other site 743720006935 catalytic residues [active] 743720006936 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 743720006937 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 743720006938 Predicted membrane protein [Function unknown]; Region: COG3212 743720006939 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720006940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006941 active site 743720006942 phosphorylation site [posttranslational modification] 743720006943 intermolecular recognition site; other site 743720006944 dimerization interface [polypeptide binding]; other site 743720006945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720006946 DNA binding site [nucleotide binding] 743720006947 sensor protein PhoQ; Provisional; Region: PRK10815 743720006948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720006949 ATP binding site [chemical binding]; other site 743720006950 G-X-G motif; other site 743720006951 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 743720006952 Predicted permease [General function prediction only]; Region: COG2056 743720006953 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 743720006954 Cache domain; Region: Cache_2; cl07034 743720006955 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720006956 dimerization interface [polypeptide binding]; other site 743720006957 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720006958 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720006959 dimer interface [polypeptide binding]; other site 743720006960 putative CheW interface [polypeptide binding]; other site 743720006961 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 743720006962 Domain of unknown function DUF20; Region: UPF0118; pfam01594 743720006963 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 743720006964 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 743720006965 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 743720006966 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 743720006967 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 743720006968 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 743720006969 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 743720006970 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 743720006971 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 743720006972 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 743720006973 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 743720006974 4Fe-4S binding domain; Region: Fer4; cl02805 743720006975 4Fe-4S binding domain; Region: Fer4; cl02805 743720006976 NADH dehydrogenase; Region: NADHdh; cl00469 743720006977 NADH dehydrogenase subunit G; Validated; Region: PRK08166 743720006978 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720006979 catalytic loop [active] 743720006980 iron binding site [ion binding]; other site 743720006981 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 743720006982 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 743720006983 [4Fe-4S] binding site [ion binding]; other site 743720006984 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 743720006985 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 743720006986 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 743720006987 SLBB domain; Region: SLBB; pfam10531 743720006988 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 743720006989 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 743720006990 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 743720006991 putative dimer interface [polypeptide binding]; other site 743720006992 [2Fe-2S] cluster binding site [ion binding]; other site 743720006993 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 743720006994 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 743720006995 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 743720006996 NADH dehydrogenase subunit B; Validated; Region: PRK06411 743720006997 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 743720006998 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 743720006999 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 743720007000 tetramer interface [polypeptide binding]; other site 743720007001 active site 743720007002 Mg2+/Mn2+ binding site [ion binding]; other site 743720007003 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 743720007004 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 743720007005 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 743720007006 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720007007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720007008 Coenzyme A binding pocket [chemical binding]; other site 743720007009 Uncharacterized conserved protein [Function unknown]; Region: COG2850 743720007010 JmjC domain, hydroxylase; Region: JmjC; cl15814 743720007011 adenylosuccinate lyase; Provisional; Region: PRK09285 743720007012 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 743720007013 tetramer interface [polypeptide binding]; other site 743720007014 active site 743720007015 Protein of unknown function (DUF489); Region: DUF489; cl01097 743720007016 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 743720007017 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 743720007018 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 743720007019 nudix motif; other site 743720007020 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 743720007021 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 743720007022 DNA-binding site [nucleotide binding]; DNA binding site 743720007023 RNA-binding motif; other site 743720007024 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 743720007025 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 743720007026 Clp amino terminal domain; Region: Clp_N; pfam02861 743720007027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720007028 Walker A motif; other site 743720007029 ATP binding site [chemical binding]; other site 743720007030 Walker B motif; other site 743720007031 arginine finger; other site 743720007032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720007033 Walker A motif; other site 743720007034 ATP binding site [chemical binding]; other site 743720007035 Walker B motif; other site 743720007036 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 743720007037 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 743720007038 rRNA binding site [nucleotide binding]; other site 743720007039 predicted 30S ribosome binding site; other site 743720007040 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 743720007041 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 743720007042 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720007043 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720007044 thioredoxin reductase; Provisional; Region: PRK10262 743720007045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720007046 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 743720007047 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 743720007048 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720007049 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 743720007050 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 743720007051 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 743720007052 recombination factor protein RarA; Reviewed; Region: PRK13342 743720007053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720007054 Walker A motif; other site 743720007055 ATP binding site [chemical binding]; other site 743720007056 Walker B motif; other site 743720007057 arginine finger; other site 743720007058 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 743720007059 CrcB-like protein; Region: CRCB; cl09114 743720007060 seryl-tRNA synthetase; Provisional; Region: PRK05431 743720007061 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 743720007062 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 743720007063 dimer interface [polypeptide binding]; other site 743720007064 active site 743720007065 motif 1; other site 743720007066 motif 2; other site 743720007067 motif 3; other site 743720007068 siroheme synthase; Provisional; Region: cysG; PRK10637 743720007069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007070 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 743720007071 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 743720007072 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720007073 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 743720007074 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743720007075 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 743720007076 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 743720007077 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 743720007078 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743720007079 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720007080 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720007081 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 743720007082 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720007083 NAD(P) binding site [chemical binding]; other site 743720007084 catalytic residues [active] 743720007085 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 743720007086 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720007087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720007088 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720007089 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 743720007090 NAD(P) binding site [chemical binding]; other site 743720007091 catalytic residues [active] 743720007092 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 743720007093 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 743720007094 dimer interface [polypeptide binding]; other site 743720007095 active site 743720007096 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720007097 substrate binding site [chemical binding]; other site 743720007098 catalytic residue [active] 743720007099 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720007100 Helix-turn-helix domains; Region: HTH; cl00088 743720007101 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 743720007102 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 743720007103 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 743720007104 uncharacterized xylulose kinase-like proteins, subgroup 2; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 743720007105 N- and C-terminal domain interface [polypeptide binding]; other site 743720007106 active site 743720007107 catalytic site [active] 743720007108 metal binding site [ion binding]; metal-binding site 743720007109 xylulose binding site [chemical binding]; other site 743720007110 ATP binding site [chemical binding]; other site 743720007111 putative homodimer interface [polypeptide binding]; other site 743720007112 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 743720007113 intersubunit interface [polypeptide binding]; other site 743720007114 active site 743720007115 Zn2+ binding site [ion binding]; other site 743720007116 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 743720007117 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720007118 inhibitor-cofactor binding pocket; inhibition site 743720007119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720007120 catalytic residue [active] 743720007121 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 743720007122 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 743720007123 short chain dehydrogenase; Provisional; Region: PRK06181 743720007124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007125 NAD(P) binding site [chemical binding]; other site 743720007126 active site 743720007127 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 743720007128 SurA N-terminal domain; Region: SurA_N_3; cl07813 743720007129 Helix-turn-helix domain; Region: HTH_18; pfam12833 743720007130 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720007131 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 743720007132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007133 classical (c) SDRs; Region: SDR_c; cd05233 743720007134 NAD(P) binding site [chemical binding]; other site 743720007135 active site 743720007136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720007137 Helix-turn-helix domains; Region: HTH; cl00088 743720007138 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 743720007139 putative substrate binding pocket [chemical binding]; other site 743720007140 putative dimerization interface [polypeptide binding]; other site 743720007141 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 743720007142 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 743720007143 putative NAD(P) binding site [chemical binding]; other site 743720007144 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743720007145 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720007146 DNA binding site [nucleotide binding] 743720007147 domain linker motif; other site 743720007148 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 743720007149 putative ligand binding site [chemical binding]; other site 743720007150 putative dimerization interface [polypeptide binding]; other site 743720007151 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 743720007152 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 743720007153 ATP-binding site [chemical binding]; other site 743720007154 Gluconate-6-phosphate binding site [chemical binding]; other site 743720007155 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 743720007156 GntP family permease; Region: GntP_permease; pfam02447 743720007157 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720007158 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720007159 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720007160 Zn2+ binding site [ion binding]; other site 743720007161 Mg2+ binding site [ion binding]; other site 743720007162 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720007163 DNA binding residues [nucleotide binding] 743720007164 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743720007165 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720007166 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 743720007167 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743720007168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720007169 Helix-turn-helix domains; Region: HTH; cl00088 743720007170 WHG domain; Region: WHG; pfam13305 743720007171 enoyl-CoA hydratase; Provisional; Region: PRK06142 743720007172 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720007173 substrate binding site [chemical binding]; other site 743720007174 oxyanion hole (OAH) forming residues; other site 743720007175 trimer interface [polypeptide binding]; other site 743720007176 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 743720007177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007178 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 743720007179 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 743720007180 FAD binding pocket [chemical binding]; other site 743720007181 FAD binding motif [chemical binding]; other site 743720007182 phosphate binding motif [ion binding]; other site 743720007183 beta-alpha-beta structure motif; other site 743720007184 NAD binding pocket [chemical binding]; other site 743720007185 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720007186 catalytic loop [active] 743720007187 iron binding site [ion binding]; other site 743720007188 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 743720007189 AMIN domain; Region: AMIN; pfam11741 743720007190 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 743720007191 active site 743720007192 metal binding site [ion binding]; metal-binding site 743720007193 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 743720007194 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 743720007195 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 743720007196 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 743720007197 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 743720007198 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 743720007199 Walker A/P-loop; other site 743720007200 ATP binding site [chemical binding]; other site 743720007201 Q-loop/lid; other site 743720007202 ABC transporter signature motif; other site 743720007203 Walker B; other site 743720007204 D-loop; other site 743720007205 H-loop/switch region; other site 743720007206 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720007207 dimer interface [polypeptide binding]; other site 743720007208 putative PBP binding regions; other site 743720007209 ABC-ATPase subunit interface; other site 743720007210 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720007211 ABC-ATPase subunit interface; other site 743720007212 dimer interface [polypeptide binding]; other site 743720007213 putative PBP binding regions; other site 743720007214 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 743720007215 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 743720007216 siderophore binding site; other site 743720007217 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 743720007218 IucA / IucC family; Region: IucA_IucC; pfam04183 743720007219 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 743720007220 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 743720007221 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 743720007222 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 743720007223 IucA / IucC family; Region: IucA_IucC; pfam04183 743720007224 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 743720007225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720007226 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 743720007227 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 743720007228 dimer interface [polypeptide binding]; other site 743720007229 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 743720007230 active site 743720007231 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720007232 catalytic residues [active] 743720007233 substrate binding site [chemical binding]; other site 743720007234 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 743720007235 IucA / IucC family; Region: IucA_IucC; pfam04183 743720007236 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 743720007237 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 743720007238 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720007239 inhibitor-cofactor binding pocket; inhibition site 743720007240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720007241 catalytic residue [active] 743720007242 Secretin and TonB N terminus short domain; Region: STN; cl06624 743720007243 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743720007244 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720007245 N-terminal plug; other site 743720007246 ligand-binding site [chemical binding]; other site 743720007247 fec operon regulator FecR; Reviewed; Region: PRK09774 743720007248 FecR protein; Region: FecR; pfam04773 743720007249 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 743720007250 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720007251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 743720007252 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 743720007253 substrate binding pocket [chemical binding]; other site 743720007254 chain length determination region; other site 743720007255 substrate-Mg2+ binding site; other site 743720007256 catalytic residues [active] 743720007257 aspartate-rich region 1; other site 743720007258 active site lid residues [active] 743720007259 aspartate-rich region 2; other site 743720007260 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 743720007261 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 743720007262 homotetramer interface [polypeptide binding]; other site 743720007263 FMN binding site [chemical binding]; other site 743720007264 homodimer contacts [polypeptide binding]; other site 743720007265 putative active site [active] 743720007266 putative substrate binding site [chemical binding]; other site 743720007267 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 743720007268 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 743720007269 active site 743720007270 TDP-binding site; other site 743720007271 acceptor substrate-binding pocket; other site 743720007272 homodimer interface [polypeptide binding]; other site 743720007273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007274 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 743720007275 phytoene desaturase; Region: crtI_fam; TIGR02734 743720007276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007277 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 743720007278 active site lid residues [active] 743720007279 substrate binding pocket [chemical binding]; other site 743720007280 catalytic residues [active] 743720007281 substrate-Mg2+ binding site; other site 743720007282 aspartate-rich region 1; other site 743720007283 aspartate-rich region 2; other site 743720007284 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 743720007285 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 743720007286 active site 743720007287 tetramer interface; other site 743720007288 Competence-damaged protein; Region: CinA; cl00666 743720007289 hypothetical protein; Provisional; Region: PRK09126 743720007290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720007292 dimer interface [polypeptide binding]; other site 743720007293 conserved gate region; other site 743720007294 putative PBP binding loops; other site 743720007295 ABC-ATPase subunit interface; other site 743720007296 sulfate transport protein; Provisional; Region: cysT; CHL00187 743720007297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720007298 dimer interface [polypeptide binding]; other site 743720007299 conserved gate region; other site 743720007300 putative PBP binding loops; other site 743720007301 ABC-ATPase subunit interface; other site 743720007302 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720007303 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 743720007304 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 743720007305 NMT1-like family; Region: NMT1_2; cl15260 743720007306 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 743720007307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743720007308 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 743720007309 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 743720007310 Walker A/P-loop; other site 743720007311 ATP binding site [chemical binding]; other site 743720007312 Q-loop/lid; other site 743720007313 ABC transporter signature motif; other site 743720007314 Walker B; other site 743720007315 D-loop; other site 743720007316 H-loop/switch region; other site 743720007317 NMT1-like family; Region: NMT1_2; cl15260 743720007318 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 743720007319 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 743720007320 active site 743720007321 iron coordination sites [ion binding]; other site 743720007322 substrate binding pocket [chemical binding]; other site 743720007323 NMT1-like family; Region: NMT1_2; cl15260 743720007324 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 743720007325 D-cysteine desulfhydrase; Validated; Region: PRK03910 743720007326 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 743720007327 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720007328 catalytic residue [active] 743720007329 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720007330 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720007331 substrate binding pocket [chemical binding]; other site 743720007332 membrane-bound complex binding site; other site 743720007333 hinge residues; other site 743720007334 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720007335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720007336 dimer interface [polypeptide binding]; other site 743720007337 conserved gate region; other site 743720007338 putative PBP binding loops; other site 743720007339 ABC-ATPase subunit interface; other site 743720007340 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 743720007341 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 743720007342 Walker A/P-loop; other site 743720007343 ATP binding site [chemical binding]; other site 743720007344 Q-loop/lid; other site 743720007345 ABC transporter signature motif; other site 743720007346 Walker B; other site 743720007347 D-loop; other site 743720007348 H-loop/switch region; other site 743720007349 Predicted membrane protein [Function unknown]; Region: COG2860 743720007350 UPF0126 domain; Region: UPF0126; pfam03458 743720007351 UPF0126 domain; Region: UPF0126; pfam03458 743720007352 glutathione reductase; Validated; Region: PRK06116 743720007353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720007354 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743720007355 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720007356 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 743720007357 active site 743720007358 metal binding site [ion binding]; metal-binding site 743720007359 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 743720007360 active site 743720007361 tetramer interface; other site 743720007362 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 743720007363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743720007364 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720007365 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 743720007366 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 743720007367 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 743720007368 Arc-like DNA binding domain; Region: Arc; pfam03869 743720007369 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 743720007370 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 743720007371 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 743720007372 GIY-YIG motif/motif A; other site 743720007373 active site 743720007374 catalytic site [active] 743720007375 putative DNA binding site [nucleotide binding]; other site 743720007376 metal binding site [ion binding]; metal-binding site 743720007377 UvrB/uvrC motif; Region: UVR; pfam02151 743720007378 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 743720007379 response regulator; Provisional; Region: PRK09483 743720007380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720007381 active site 743720007382 phosphorylation site [posttranslational modification] 743720007383 intermolecular recognition site; other site 743720007384 dimerization interface [polypeptide binding]; other site 743720007385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720007386 DNA binding residues [nucleotide binding] 743720007387 dimerization interface [polypeptide binding]; other site 743720007388 YccA-like proteins; Region: YccA_like; cd10433 743720007389 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 743720007390 putative lipid binding site [chemical binding]; other site 743720007391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720007392 dimer interface [polypeptide binding]; other site 743720007393 phosphorylation site [posttranslational modification] 743720007394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720007395 ATP binding site [chemical binding]; other site 743720007396 Mg2+ binding site [ion binding]; other site 743720007397 G-X-G motif; other site 743720007398 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720007399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720007400 active site 743720007401 phosphorylation site [posttranslational modification] 743720007402 intermolecular recognition site; other site 743720007403 dimerization interface [polypeptide binding]; other site 743720007404 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 743720007405 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720007406 metal binding site [ion binding]; metal-binding site 743720007407 active site 743720007408 I-site; other site 743720007409 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720007410 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 743720007411 active site 743720007412 substrate binding site [chemical binding]; other site 743720007413 catalytic site [active] 743720007414 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 743720007415 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 743720007416 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 743720007417 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 743720007418 substrate binding site [chemical binding]; other site 743720007419 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 743720007420 substrate binding site [chemical binding]; other site 743720007421 ligand binding site [chemical binding]; other site 743720007422 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 743720007423 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720007424 catalytic residue [active] 743720007425 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720007426 aminotransferase; Validated; Region: PRK08175 743720007427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720007428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720007429 homodimer interface [polypeptide binding]; other site 743720007430 catalytic residue [active] 743720007431 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 743720007432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720007433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720007434 Walker B motif; other site 743720007435 arginine finger; other site 743720007436 Helix-turn-helix domains; Region: HTH; cl00088 743720007437 Citrate transporter; Region: CitMHS; pfam03600 743720007438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007439 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 743720007440 NAD(P) binding site [chemical binding]; other site 743720007441 active site 743720007442 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 743720007443 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 743720007444 AMP-binding enzyme; Region: AMP-binding; cl15778 743720007445 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720007446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720007447 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720007448 substrate binding pocket [chemical binding]; other site 743720007449 membrane-bound complex binding site; other site 743720007450 hinge residues; other site 743720007451 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 743720007452 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 743720007453 conserved cys residue [active] 743720007454 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 743720007455 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 743720007456 Walker A motif; other site 743720007457 ATP binding site [chemical binding]; other site 743720007458 Walker B motif; other site 743720007459 PPIC-type PPIASE domain; Region: Rotamase; cl08278 743720007460 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 743720007461 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 743720007462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 743720007463 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 743720007464 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 743720007465 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 743720007466 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 743720007467 Helix-turn-helix domains; Region: HTH; cl00088 743720007468 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720007469 dimerization interface [polypeptide binding]; other site 743720007470 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 743720007471 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 743720007472 active site residue [active] 743720007473 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 743720007474 active site residue [active] 743720007475 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 743720007476 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 743720007477 Walker A/P-loop; other site 743720007478 ATP binding site [chemical binding]; other site 743720007479 Q-loop/lid; other site 743720007480 ABC transporter signature motif; other site 743720007481 Walker B; other site 743720007482 D-loop; other site 743720007483 H-loop/switch region; other site 743720007484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720007485 dimer interface [polypeptide binding]; other site 743720007486 conserved gate region; other site 743720007487 putative PBP binding loops; other site 743720007488 ABC-ATPase subunit interface; other site 743720007489 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 743720007490 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720007491 substrate binding pocket [chemical binding]; other site 743720007492 membrane-bound complex binding site; other site 743720007493 hinge residues; other site 743720007494 outer membrane porin, OprD family; Region: OprD; pfam03573 743720007495 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 743720007496 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720007497 substrate binding pocket [chemical binding]; other site 743720007498 membrane-bound complex binding site; other site 743720007499 hinge residues; other site 743720007500 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 743720007501 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 743720007502 Flavin binding site [chemical binding]; other site 743720007503 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 743720007504 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720007505 active site 743720007506 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 743720007507 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720007508 active site 743720007509 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 743720007510 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 743720007511 active site 743720007512 non-prolyl cis peptide bond; other site 743720007513 NMT1-like family; Region: NMT1_2; cl15260 743720007514 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 743720007515 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 743720007516 Walker A/P-loop; other site 743720007517 ATP binding site [chemical binding]; other site 743720007518 Q-loop/lid; other site 743720007519 ABC transporter signature motif; other site 743720007520 Walker B; other site 743720007521 D-loop; other site 743720007522 H-loop/switch region; other site 743720007523 NIL domain; Region: NIL; cl09633 743720007524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720007525 dimer interface [polypeptide binding]; other site 743720007526 conserved gate region; other site 743720007527 ABC-ATPase subunit interface; other site 743720007528 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 743720007529 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 743720007530 active site 743720007531 non-prolyl cis peptide bond; other site 743720007532 Cupin domain; Region: Cupin_2; cl09118 743720007533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720007534 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720007535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720007536 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720007537 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720007538 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720007539 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720007540 metal binding site [ion binding]; metal-binding site 743720007541 active site 743720007542 I-site; other site 743720007543 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 743720007544 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 743720007545 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720007546 Walker A/P-loop; other site 743720007547 ATP binding site [chemical binding]; other site 743720007548 Q-loop/lid; other site 743720007549 ABC transporter signature motif; other site 743720007550 Walker B; other site 743720007551 D-loop; other site 743720007552 H-loop/switch region; other site 743720007553 ABC transporter; Region: ABC_tran_2; pfam12848 743720007554 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 743720007555 heat shock protein 90; Provisional; Region: PRK05218 743720007556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 743720007557 MAPEG family; Region: MAPEG; cl09190 743720007558 Protein of unknown function, DUF599; Region: DUF599; cl01575 743720007559 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 743720007560 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 743720007561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007562 CoA-ligase; Region: Ligase_CoA; cl02894 743720007563 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 743720007564 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720007565 CoA-ligase; Region: Ligase_CoA; cl02894 743720007566 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 743720007567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007568 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720007569 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743720007570 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 743720007571 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743720007572 E3 interaction surface; other site 743720007573 lipoyl attachment site [posttranslational modification]; other site 743720007574 e3 binding domain; Region: E3_binding; pfam02817 743720007575 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 743720007576 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 743720007577 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 743720007578 TPP-binding site [chemical binding]; other site 743720007579 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 743720007580 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 743720007581 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 743720007582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007583 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 743720007584 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 743720007585 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 743720007586 SdhC subunit interface [polypeptide binding]; other site 743720007587 proximal heme binding site [chemical binding]; other site 743720007588 cardiolipin binding site; other site 743720007589 Iron-sulfur protein interface; other site 743720007590 proximal quinone binding site [chemical binding]; other site 743720007591 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 743720007592 Iron-sulfur protein interface; other site 743720007593 proximal quinone binding site [chemical binding]; other site 743720007594 SdhD (CybS) interface [polypeptide binding]; other site 743720007595 proximal heme binding site [chemical binding]; other site 743720007596 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 743720007597 dimer interface [polypeptide binding]; other site 743720007598 Citrate synthase; Region: Citrate_synt; pfam00285 743720007599 active site 743720007600 citrylCoA binding site [chemical binding]; other site 743720007601 NADH binding [chemical binding]; other site 743720007602 cationic pore residues; other site 743720007603 oxalacetate/citrate binding site [chemical binding]; other site 743720007604 coenzyme A binding site [chemical binding]; other site 743720007605 catalytic triad [active] 743720007606 DsrE/DsrF-like family; Region: DrsE; cl00672 743720007607 DsrE/DsrF-like family; Region: DrsE; cl00672 743720007608 DsrE/DsrF-like family; Region: DrsE; cl00672 743720007609 DsrC like protein; Region: DsrC; cl01101 743720007610 hypothetical protein; Validated; Region: PRK09071 743720007611 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 743720007612 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 743720007613 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 743720007614 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743720007615 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 743720007616 putative dimer interface [polypeptide binding]; other site 743720007617 N-terminal domain interface [polypeptide binding]; other site 743720007618 putative substrate binding pocket (H-site) [chemical binding]; other site 743720007619 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 743720007620 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 743720007621 Protein export membrane protein; Region: SecD_SecF; cl14618 743720007622 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 743720007623 Protein export membrane protein; Region: SecD_SecF; cl14618 743720007624 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 743720007625 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720007626 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720007627 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 743720007628 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 743720007629 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 743720007630 Dehydratase family; Region: ILVD_EDD; cl00340 743720007631 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 743720007632 classical (c) SDRs; Region: SDR_c; cd05233 743720007633 NAD(P) binding site [chemical binding]; other site 743720007634 active site 743720007635 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 743720007636 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 743720007637 TM-ABC transporter signature motif; other site 743720007638 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 743720007639 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 743720007640 Walker A/P-loop; other site 743720007641 ATP binding site [chemical binding]; other site 743720007642 Q-loop/lid; other site 743720007643 ABC transporter signature motif; other site 743720007644 Walker B; other site 743720007645 D-loop; other site 743720007646 H-loop/switch region; other site 743720007647 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 743720007648 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 743720007649 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 743720007650 putative ligand binding site [chemical binding]; other site 743720007651 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 743720007652 Helix-turn-helix domains; Region: HTH; cl00088 743720007653 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720007654 dimerization interface [polypeptide binding]; other site 743720007655 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 743720007656 dimer interface [polypeptide binding]; other site 743720007657 catalytic triad [active] 743720007658 peroxidatic and resolving cysteines [active] 743720007659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 743720007660 Family of unknown function (DUF490); Region: DUF490; pfam04357 743720007661 Family of unknown function (DUF490); Region: DUF490; pfam04357 743720007662 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 743720007663 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 743720007664 Surface antigen; Region: Bac_surface_Ag; cl03097 743720007665 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 743720007666 putative phosphate binding site [ion binding]; other site 743720007667 putative catalytic site [active] 743720007668 active site 743720007669 metal binding site A [ion binding]; metal-binding site 743720007670 DNA binding site [nucleotide binding] 743720007671 putative AP binding site [nucleotide binding]; other site 743720007672 putative metal binding site B [ion binding]; other site 743720007673 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720007674 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720007675 ligand binding site [chemical binding]; other site 743720007676 Integral membrane protein TerC family; Region: TerC; cl10468 743720007677 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 743720007678 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 743720007679 FAD binding site [chemical binding]; other site 743720007680 substrate binding site [chemical binding]; other site 743720007681 catalytic base [active] 743720007682 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 743720007683 Helix-turn-helix domains; Region: HTH; cl00088 743720007684 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 743720007685 substrate binding pocket [chemical binding]; other site 743720007686 dimerization interface [polypeptide binding]; other site 743720007687 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 743720007688 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720007689 ligand binding site [chemical binding]; other site 743720007690 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 743720007691 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720007692 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720007693 DNA binding residues [nucleotide binding] 743720007694 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 743720007695 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 743720007696 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 743720007697 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720007698 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720007699 phosphoenolpyruvate synthase; Validated; Region: PRK06464 743720007700 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 743720007701 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 743720007702 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 743720007703 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 743720007704 LysE type translocator; Region: LysE; cl00565 743720007705 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 743720007706 PrpF protein; Region: PrpF; pfam04303 743720007707 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 743720007708 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 743720007709 substrate binding site [chemical binding]; other site 743720007710 ligand binding site [chemical binding]; other site 743720007711 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 743720007712 substrate binding site [chemical binding]; other site 743720007713 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 743720007714 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 743720007715 dimer interface [polypeptide binding]; other site 743720007716 active site 743720007717 citrylCoA binding site [chemical binding]; other site 743720007718 oxalacetate/citrate binding site [chemical binding]; other site 743720007719 coenzyme A binding site [chemical binding]; other site 743720007720 catalytic triad [active] 743720007721 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 743720007722 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 743720007723 tetramer interface [polypeptide binding]; other site 743720007724 active site 743720007725 Mg2+/Mn2+ binding site [ion binding]; other site 743720007726 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720007727 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720007728 DNA-binding site [nucleotide binding]; DNA binding site 743720007729 FCD domain; Region: FCD; cl11656 743720007730 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 743720007731 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 743720007732 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 743720007733 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720007734 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 743720007735 Active Sites [active] 743720007736 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 743720007737 Helix-turn-helix domains; Region: HTH; cl00088 743720007738 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 743720007739 substrate binding site [chemical binding]; other site 743720007740 dimerization interface [polypeptide binding]; other site 743720007741 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720007742 Ligand Binding Site [chemical binding]; other site 743720007743 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743720007744 catalytic residues [active] 743720007745 PilZ domain; Region: PilZ; cl01260 743720007746 NeuB family; Region: NeuB; cl00496 743720007747 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 743720007748 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720007749 L,D-transpeptidase; Provisional; Region: PRK10260 743720007750 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 743720007751 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 743720007752 active site 743720007753 catalytic triad [active] 743720007754 oxyanion hole [active] 743720007755 switch loop; other site 743720007756 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 743720007757 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 743720007758 Walker A/P-loop; other site 743720007759 ATP binding site [chemical binding]; other site 743720007760 Q-loop/lid; other site 743720007761 ABC transporter signature motif; other site 743720007762 Walker B; other site 743720007763 D-loop; other site 743720007764 H-loop/switch region; other site 743720007765 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 743720007766 FtsX-like permease family; Region: FtsX; cl15850 743720007767 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 743720007768 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 743720007769 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 743720007770 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743720007771 DoxX; Region: DoxX; cl00976 743720007772 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720007773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720007774 dimerization interface [polypeptide binding]; other site 743720007775 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 743720007776 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720007777 catalytic residue [active] 743720007778 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 743720007779 active site 743720007780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720007781 dimerization interface [polypeptide binding]; other site 743720007782 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 743720007783 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720007784 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720007785 dimer interface [polypeptide binding]; other site 743720007786 putative CheW interface [polypeptide binding]; other site 743720007787 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 743720007788 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 743720007789 active site 743720007790 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 743720007791 active site 2 [active] 743720007792 active site 1 [active] 743720007793 CHAD domain; Region: CHAD; cl10506 743720007794 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 743720007795 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 743720007796 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 743720007797 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 743720007798 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 743720007799 MoxR-like ATPases [General function prediction only]; Region: COG0714 743720007800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720007801 Walker A motif; other site 743720007802 ATP binding site [chemical binding]; other site 743720007803 Walker B motif; other site 743720007804 arginine finger; other site 743720007805 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720007806 dimerization interface [polypeptide binding]; other site 743720007807 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720007808 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720007809 dimer interface [polypeptide binding]; other site 743720007810 putative CheW interface [polypeptide binding]; other site 743720007811 Flavin Reductases; Region: FlaRed; cl00801 743720007812 hypothetical protein; Provisional; Region: PRK10279 743720007813 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 743720007814 active site 743720007815 nucleophile elbow; other site 743720007816 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 743720007817 Domain of unknown function DUF20; Region: UPF0118; pfam01594 743720007818 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720007819 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720007820 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720007821 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 743720007822 CoenzymeA binding site [chemical binding]; other site 743720007823 subunit interaction site [polypeptide binding]; other site 743720007824 PHB binding site; other site 743720007825 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 743720007826 catalytic core [active] 743720007827 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 743720007828 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 743720007829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007830 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 743720007831 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 743720007832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720007833 dimer interface [polypeptide binding]; other site 743720007834 phosphorylation site [posttranslational modification] 743720007835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720007836 ATP binding site [chemical binding]; other site 743720007837 Mg2+ binding site [ion binding]; other site 743720007838 G-X-G motif; other site 743720007839 Response regulator receiver domain; Region: Response_reg; pfam00072 743720007840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720007841 active site 743720007842 phosphorylation site [posttranslational modification] 743720007843 intermolecular recognition site; other site 743720007844 dimerization interface [polypeptide binding]; other site 743720007845 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 743720007846 active site 1 [active] 743720007847 dimer interface [polypeptide binding]; other site 743720007848 active site 2 [active] 743720007849 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 743720007850 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 743720007851 dimer interface [polypeptide binding]; other site 743720007852 active site 743720007853 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 743720007854 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743720007855 RNA polymerase sigma factor; Provisional; Region: PRK12537 743720007856 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720007857 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720007858 DNA binding residues [nucleotide binding] 743720007859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 743720007860 Anti-sigma-K factor rskA; Region: RskA; pfam10099 743720007861 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 743720007862 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 743720007863 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720007864 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 743720007865 LysR family transcriptional regulator; Provisional; Region: PRK14997 743720007866 Helix-turn-helix domains; Region: HTH; cl00088 743720007867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720007868 dimerization interface [polypeptide binding]; other site 743720007869 major facilitator superfamily transporter; Provisional; Region: PRK05122 743720007870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720007871 putative substrate translocation pore; other site 743720007872 Protein of unknown function (DUF419); Region: DUF419; cl15265 743720007873 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 743720007874 DNA-binding site [nucleotide binding]; DNA binding site 743720007875 RNA-binding motif; other site 743720007876 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 743720007877 Bacitracin resistance protein BacA; Region: BacA; cl00858 743720007878 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 743720007879 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720007880 AAA domain; Region: AAA_28; pfam13521 743720007881 Cytochrome c; Region: Cytochrom_C; cl11414 743720007882 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 743720007883 putative heme binding pocket [chemical binding]; other site 743720007884 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 743720007885 active site 743720007886 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 743720007887 trimer interface [polypeptide binding]; other site 743720007888 active site 743720007889 dimer interface [polypeptide binding]; other site 743720007890 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 743720007891 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 743720007892 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 743720007893 shikimate binding site; other site 743720007894 NAD(P) binding site [chemical binding]; other site 743720007895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720007896 Helix-turn-helix domains; Region: HTH; cl00088 743720007897 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 743720007898 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 743720007899 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 743720007900 dimer interface [polypeptide binding]; other site 743720007901 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 743720007902 active site 743720007903 Fe binding site [ion binding]; other site 743720007904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720007905 metabolite-proton symporter; Region: 2A0106; TIGR00883 743720007906 putative substrate translocation pore; other site 743720007907 EamA-like transporter family; Region: EamA; cl01037 743720007908 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 743720007909 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 743720007910 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 743720007911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007912 Transcriptional regulator [Transcription]; Region: IclR; COG1414 743720007913 Helix-turn-helix domains; Region: HTH; cl00088 743720007914 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720007915 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 743720007916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 743720007917 NMT1-like family; Region: NMT1_2; cl15260 743720007918 outer membrane porin, OprD family; Region: OprD; pfam03573 743720007919 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720007920 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720007921 dimerization interface [polypeptide binding]; other site 743720007922 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720007923 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720007924 dimer interface [polypeptide binding]; other site 743720007925 putative CheW interface [polypeptide binding]; other site 743720007926 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743720007927 IHF - DNA interface [nucleotide binding]; other site 743720007928 IHF dimer interface [polypeptide binding]; other site 743720007929 OPT oligopeptide transporter protein; Region: OPT; cl14607 743720007930 OPT oligopeptide transporter protein; Region: OPT; cl14607 743720007931 Ligase N family; Region: LIGANc; smart00532 743720007932 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 743720007933 nucleotide binding pocket [chemical binding]; other site 743720007934 K-X-D-G motif; other site 743720007935 catalytic site [active] 743720007936 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 743720007937 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 743720007938 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 743720007939 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 743720007940 Dimer interface [polypeptide binding]; other site 743720007941 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 743720007942 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 743720007943 FtsZ protein binding site [polypeptide binding]; other site 743720007944 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 743720007945 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 743720007946 Walker A/P-loop; other site 743720007947 ATP binding site [chemical binding]; other site 743720007948 Q-loop/lid; other site 743720007949 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 743720007950 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 743720007951 ABC transporter signature motif; other site 743720007952 Walker B; other site 743720007953 D-loop; other site 743720007954 H-loop/switch region; other site 743720007955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720007956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 743720007957 guanine deaminase; Provisional; Region: PRK09228 743720007958 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 743720007959 active site 743720007960 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 743720007961 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 743720007962 Walker A/P-loop; other site 743720007963 ATP binding site [chemical binding]; other site 743720007964 Q-loop/lid; other site 743720007965 ABC transporter signature motif; other site 743720007966 Walker B; other site 743720007967 D-loop; other site 743720007968 H-loop/switch region; other site 743720007969 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720007970 ABC-ATPase subunit interface; other site 743720007971 dimer interface [polypeptide binding]; other site 743720007972 putative PBP binding regions; other site 743720007973 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 743720007974 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 743720007975 intersubunit interface [polypeptide binding]; other site 743720007976 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 743720007977 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 743720007978 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720007979 FeS/SAM binding site; other site 743720007980 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 743720007981 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 743720007982 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 743720007983 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 743720007984 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 743720007985 Cytochrome c; Region: Cytochrom_C; cl11414 743720007986 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 743720007987 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 743720007988 D-pathway; other site 743720007989 Putative ubiquinol binding site [chemical binding]; other site 743720007990 Low-spin heme (heme b) binding site [chemical binding]; other site 743720007991 Putative water exit pathway; other site 743720007992 Binuclear center (heme o3/CuB) [ion binding]; other site 743720007993 K-pathway; other site 743720007994 Putative proton exit pathway; other site 743720007995 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720007996 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 743720007997 conserved cys residue [active] 743720007998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720007999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720008000 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 743720008001 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 743720008002 Walker A/P-loop; other site 743720008003 ATP binding site [chemical binding]; other site 743720008004 Q-loop/lid; other site 743720008005 ABC transporter signature motif; other site 743720008006 Walker B; other site 743720008007 D-loop; other site 743720008008 H-loop/switch region; other site 743720008009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720008010 dimer interface [polypeptide binding]; other site 743720008011 conserved gate region; other site 743720008012 putative PBP binding loops; other site 743720008013 ABC-ATPase subunit interface; other site 743720008014 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720008015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720008016 dimer interface [polypeptide binding]; other site 743720008017 conserved gate region; other site 743720008018 putative PBP binding loops; other site 743720008019 ABC-ATPase subunit interface; other site 743720008020 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 743720008021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720008022 substrate binding pocket [chemical binding]; other site 743720008023 membrane-bound complex binding site; other site 743720008024 hinge residues; other site 743720008025 acetyl-CoA synthetase; Provisional; Region: PRK00174 743720008026 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 743720008027 AMP-binding enzyme; Region: AMP-binding; cl15778 743720008028 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720008029 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 743720008030 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 743720008031 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720008032 DctM-like transporters; Region: DctM; pfam06808 743720008033 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 743720008034 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 743720008035 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720008036 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 743720008037 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720008038 Helix-turn-helix domains; Region: HTH; cl00088 743720008039 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 743720008040 putative dimerization interface [polypeptide binding]; other site 743720008041 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 743720008042 CoA-transferase family III; Region: CoA_transf_3; pfam02515 743720008043 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 743720008044 active site 743720008045 catalytic residues [active] 743720008046 metal binding site [ion binding]; metal-binding site 743720008047 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 743720008048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720008049 putative substrate translocation pore; other site 743720008050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720008051 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 743720008052 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720008053 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720008054 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 743720008055 Helix-turn-helix domains; Region: HTH; cl00088 743720008056 Transcriptional regulators [Transcription]; Region: MarR; COG1846 743720008057 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 743720008058 putative FMN binding site [chemical binding]; other site 743720008059 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720008060 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 743720008061 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 743720008062 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 743720008063 CoA-transferase family III; Region: CoA_transf_3; pfam02515 743720008064 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 743720008065 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 743720008066 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720008067 active site 743720008068 Uncharacterized conserved protein [Function unknown]; Region: COG3777 743720008069 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 743720008070 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 743720008071 active site 2 [active] 743720008072 active site 1 [active] 743720008073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720008074 Helix-turn-helix domains; Region: HTH; cl00088 743720008075 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 743720008076 putative dimerization interface [polypeptide binding]; other site 743720008077 TolB amino-terminal domain; Region: TolB_N; cl00639 743720008078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 743720008079 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 743720008080 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 743720008081 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 743720008082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720008083 Walker A motif; other site 743720008084 ATP binding site [chemical binding]; other site 743720008085 Walker B motif; other site 743720008086 arginine finger; other site 743720008087 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 743720008088 cofactor binding site; other site 743720008089 metal binding site [ion binding]; metal-binding site 743720008090 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 743720008091 aromatic arch; other site 743720008092 DCoH dimer interaction site [polypeptide binding]; other site 743720008093 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 743720008094 DCoH tetramer interaction site [polypeptide binding]; other site 743720008095 substrate binding site [chemical binding]; other site 743720008096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720008097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720008098 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 743720008099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720008100 active site 743720008101 motif I; other site 743720008102 motif II; other site 743720008103 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 743720008104 glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398 743720008105 active site 743720008106 homotetramer interface [polypeptide binding]; other site 743720008107 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 743720008108 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 743720008109 HemK family putative methylases; Region: hemK_fam; TIGR00536 743720008110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720008111 S-adenosylmethionine binding site [chemical binding]; other site 743720008112 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 743720008113 Isochorismatase family; Region: Isochorismatase; pfam00857 743720008114 catalytic triad [active] 743720008115 conserved cis-peptide bond; other site 743720008116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 743720008117 Smr domain; Region: Smr; cl02619 743720008118 elongation factor P; Validated; Region: PRK00529 743720008119 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 743720008120 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 743720008121 RNA binding site [nucleotide binding]; other site 743720008122 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 743720008123 RNA binding site [nucleotide binding]; other site 743720008124 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823 743720008125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720008126 putative substrate translocation pore; other site 743720008127 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 743720008128 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720008129 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 743720008130 substrate binding site [chemical binding]; other site 743720008131 oxyanion hole (OAH) forming residues; other site 743720008132 trimer interface [polypeptide binding]; other site 743720008133 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 743720008134 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 743720008135 ABC-2 type transporter; Region: ABC2_membrane; cl11417 743720008136 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 743720008137 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720008138 Walker A/P-loop; other site 743720008139 ATP binding site [chemical binding]; other site 743720008140 Q-loop/lid; other site 743720008141 ABC transporter signature motif; other site 743720008142 Walker B; other site 743720008143 D-loop; other site 743720008144 H-loop/switch region; other site 743720008145 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720008146 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 743720008147 putative C-terminal domain interface [polypeptide binding]; other site 743720008148 putative GSH binding site (G-site) [chemical binding]; other site 743720008149 putative dimer interface [polypeptide binding]; other site 743720008150 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 743720008151 putative N-terminal domain interface [polypeptide binding]; other site 743720008152 putative dimer interface [polypeptide binding]; other site 743720008153 putative substrate binding pocket (H-site) [chemical binding]; other site 743720008154 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 743720008155 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 743720008156 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 743720008157 active site 743720008158 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 743720008159 GAF domain; Region: GAF; cl15785 743720008160 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 743720008161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720008162 Walker A motif; other site 743720008163 ATP binding site [chemical binding]; other site 743720008164 Walker B motif; other site 743720008165 biofilm formation regulator HmsP; Provisional; Region: PRK11829 743720008166 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 743720008167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 743720008168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720008169 ATP binding site [chemical binding]; other site 743720008170 Mg2+ binding site [ion binding]; other site 743720008171 G-X-G motif; other site 743720008172 Response regulator receiver domain; Region: Response_reg; pfam00072 743720008173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720008174 active site 743720008175 phosphorylation site [posttranslational modification] 743720008176 intermolecular recognition site; other site 743720008177 dimerization interface [polypeptide binding]; other site 743720008178 Helix-turn-helix domains; Region: HTH; cl00088 743720008179 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 743720008180 catalytic residues [active] 743720008181 dimer interface [polypeptide binding]; other site 743720008182 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 743720008183 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 743720008184 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 743720008185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720008186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720008187 homodimer interface [polypeptide binding]; other site 743720008188 catalytic residue [active] 743720008189 Peptidase family M48; Region: Peptidase_M48; cl12018 743720008190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 743720008191 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 743720008192 putative active site [active] 743720008193 metal binding site [ion binding]; metal-binding site 743720008194 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 743720008195 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 743720008196 chorismate binding enzyme; Region: Chorismate_bind; cl10555 743720008197 helicase 45; Provisional; Region: PTZ00424 743720008198 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743720008199 ATP binding site [chemical binding]; other site 743720008200 Mg++ binding site [ion binding]; other site 743720008201 motif III; other site 743720008202 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720008203 nucleotide binding region [chemical binding]; other site 743720008204 ATP-binding site [chemical binding]; other site 743720008205 DbpA RNA binding domain; Region: DbpA; pfam03880 743720008206 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 743720008207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720008208 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 743720008209 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 743720008210 CAAX protease self-immunity; Region: Abi; cl00558 743720008211 RNA polymerase sigma factor; Provisional; Region: PRK12513 743720008212 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720008213 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720008214 DNA binding residues [nucleotide binding] 743720008215 von Willebrand factor; Region: vWF_A; pfam12450 743720008216 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 743720008217 metal ion-dependent adhesion site (MIDAS); other site 743720008218 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 743720008219 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720008220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720008221 DNA-binding site [nucleotide binding]; DNA binding site 743720008222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720008223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720008224 homodimer interface [polypeptide binding]; other site 743720008225 catalytic residue [active] 743720008226 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720008227 ligand binding site [chemical binding]; other site 743720008228 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 743720008229 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720008230 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 743720008231 substrate binding pocket [chemical binding]; other site 743720008232 membrane-bound complex binding site; other site 743720008233 hinge residues; other site 743720008234 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 743720008235 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720008236 nucleophilic elbow; other site 743720008237 catalytic triad; other site 743720008238 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 743720008239 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 743720008240 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 743720008241 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 743720008242 Ligand binding site [chemical binding]; other site 743720008243 Electron transfer flavoprotein domain; Region: ETF; pfam01012 743720008244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720008245 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 743720008246 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 743720008247 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 743720008248 Helix-turn-helix domains; Region: HTH; cl00088 743720008249 WHG domain; Region: WHG; pfam13305 743720008250 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 743720008251 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 743720008252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720008253 catalytic residue [active] 743720008254 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 743720008255 active site 743720008256 PilZ domain; Region: PilZ; cl01260 743720008257 DNA polymerase III subunit delta'; Validated; Region: PRK05707 743720008258 thymidylate kinase; Validated; Region: tmk; PRK00698 743720008259 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 743720008260 TMP-binding site; other site 743720008261 ATP-binding site [chemical binding]; other site 743720008262 YceG-like family; Region: YceG; pfam02618 743720008263 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 743720008264 dimerization interface [polypeptide binding]; other site 743720008265 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 743720008266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720008267 catalytic residue [active] 743720008268 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 743720008269 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 743720008270 dimer interface [polypeptide binding]; other site 743720008271 active site 743720008272 Phosphopantetheine attachment site; Region: PP-binding; cl09936 743720008273 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 743720008274 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 743720008275 NAD(P) binding site [chemical binding]; other site 743720008276 homotetramer interface [polypeptide binding]; other site 743720008277 homodimer interface [polypeptide binding]; other site 743720008278 active site 743720008279 Acyl transferase domain; Region: Acyl_transf_1; cl08282 743720008280 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 743720008281 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 743720008282 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 743720008283 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 743720008284 Maf-like protein; Region: Maf; pfam02545 743720008285 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 743720008286 active site 743720008287 dimer interface [polypeptide binding]; other site 743720008288 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 743720008289 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720008290 Family description; Region: UvrD_C_2; cl15862 743720008291 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 743720008292 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720008293 Family description; Region: UvrD_C_2; cl15862 743720008294 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 743720008295 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 743720008296 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 743720008297 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 743720008298 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 743720008299 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 743720008300 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 743720008301 tetramer interface [polypeptide binding]; other site 743720008302 heme binding pocket [chemical binding]; other site 743720008303 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 743720008304 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 743720008305 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720008306 dimerization interface [polypeptide binding]; other site 743720008307 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720008308 dimer interface [polypeptide binding]; other site 743720008309 putative CheW interface [polypeptide binding]; other site 743720008310 Protein of unknown function (DUF421); Region: DUF421; cl00990 743720008311 amino acid transporter; Region: 2A0306; TIGR00909 743720008312 Spore germination protein; Region: Spore_permease; cl15802 743720008313 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 743720008314 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 743720008315 DNA binding residues [nucleotide binding] 743720008316 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743720008317 IHF dimer interface [polypeptide binding]; other site 743720008318 IHF - DNA interface [nucleotide binding]; other site 743720008319 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 743720008320 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 743720008321 putative tRNA-binding site [nucleotide binding]; other site 743720008322 B3/4 domain; Region: B3_4; cl11458 743720008323 tRNA synthetase B5 domain; Region: B5; cl08394 743720008324 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 743720008325 dimer interface [polypeptide binding]; other site 743720008326 motif 1; other site 743720008327 motif 3; other site 743720008328 motif 2; other site 743720008329 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 743720008330 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 743720008331 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 743720008332 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 743720008333 dimer interface [polypeptide binding]; other site 743720008334 motif 1; other site 743720008335 active site 743720008336 motif 2; other site 743720008337 motif 3; other site 743720008338 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 743720008339 23S rRNA binding site [nucleotide binding]; other site 743720008340 L21 binding site [polypeptide binding]; other site 743720008341 L13 binding site [polypeptide binding]; other site 743720008342 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 743720008343 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 743720008344 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 743720008345 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 743720008346 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 743720008347 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 743720008348 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 743720008349 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 743720008350 active site 743720008351 dimer interface [polypeptide binding]; other site 743720008352 motif 1; other site 743720008353 motif 2; other site 743720008354 motif 3; other site 743720008355 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 743720008356 anticodon binding site; other site 743720008357 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 743720008358 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 743720008359 putative active site [active] 743720008360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720008361 binding surface 743720008362 TPR motif; other site 743720008363 Tetratricopeptide repeat; Region: TPR_16; pfam13432 743720008364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720008365 Helix-turn-helix domains; Region: HTH; cl00088 743720008366 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 743720008367 putative effector binding pocket; other site 743720008368 dimerization interface [polypeptide binding]; other site 743720008369 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743720008370 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 743720008371 active site 743720008372 catalytic tetrad [active] 743720008373 RF-1 domain; Region: RF-1; cl02875 743720008374 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 743720008375 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 743720008376 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 743720008377 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720008378 dimerization interface [polypeptide binding]; other site 743720008379 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720008380 dimer interface [polypeptide binding]; other site 743720008381 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 743720008382 putative CheW interface [polypeptide binding]; other site 743720008383 aromatic amino acid transporter; Provisional; Region: PRK10238 743720008384 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 743720008385 maleylacetoacetate isomerase; Region: maiA; TIGR01262 743720008386 C-terminal domain interface [polypeptide binding]; other site 743720008387 GSH binding site (G-site) [chemical binding]; other site 743720008388 putative dimer interface [polypeptide binding]; other site 743720008389 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 743720008390 dimer interface [polypeptide binding]; other site 743720008391 N-terminal domain interface [polypeptide binding]; other site 743720008392 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 743720008393 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 743720008394 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 743720008395 Cupin domain; Region: Cupin_2; cl09118 743720008396 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 743720008397 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 743720008398 dimer interface [polypeptide binding]; other site 743720008399 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 743720008400 active site 743720008401 Fe binding site [ion binding]; other site 743720008402 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 743720008403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720008404 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 743720008405 Walker A/P-loop; other site 743720008406 ATP binding site [chemical binding]; other site 743720008407 Q-loop/lid; other site 743720008408 ABC transporter signature motif; other site 743720008409 Walker B; other site 743720008410 D-loop; other site 743720008411 H-loop/switch region; other site 743720008412 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 743720008413 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 743720008414 catalytic residues [active] 743720008415 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 743720008416 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 743720008417 active site residue [active] 743720008418 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 743720008419 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 743720008420 putative NAD(P) binding site [chemical binding]; other site 743720008421 BolA-like protein; Region: BolA; cl00386 743720008422 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 743720008423 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 743720008424 fumarate hydratase; Provisional; Region: PRK12425 743720008425 Class II fumarases; Region: Fumarase_classII; cd01362 743720008426 active site 743720008427 tetramer interface [polypeptide binding]; other site 743720008428 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 743720008429 Membrane transport protein; Region: Mem_trans; cl09117 743720008430 Predicted ATPase [General function prediction only]; Region: COG1485 743720008431 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 743720008432 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 743720008433 heterodimer interface [polypeptide binding]; other site 743720008434 active site 743720008435 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 743720008436 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 743720008437 active site 743720008438 glutathionine S-transferase; Provisional; Region: PRK10542 743720008439 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 743720008440 C-terminal domain interface [polypeptide binding]; other site 743720008441 GSH binding site (G-site) [chemical binding]; other site 743720008442 dimer interface [polypeptide binding]; other site 743720008443 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 743720008444 dimer interface [polypeptide binding]; other site 743720008445 N-terminal domain interface [polypeptide binding]; other site 743720008446 substrate binding pocket (H-site) [chemical binding]; other site 743720008447 Helix-turn-helix domains; Region: HTH; cl00088 743720008448 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 743720008449 Sel1 repeat; Region: Sel1; cl02723 743720008450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720008451 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 743720008452 NAD(P) binding site [chemical binding]; other site 743720008453 active site 743720008454 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720008455 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 743720008456 Helix-turn-helix domains; Region: HTH; cl00088 743720008457 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720008458 dimerization interface [polypeptide binding]; other site 743720008459 glycogen synthase; Provisional; Region: glgA; PRK00654 743720008460 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 743720008461 ADP-binding pocket [chemical binding]; other site 743720008462 homodimer interface [polypeptide binding]; other site 743720008463 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 743720008464 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 743720008465 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 743720008466 catalytic site [active] 743720008467 active site 743720008468 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 743720008469 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 743720008470 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 743720008471 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 743720008472 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 743720008473 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 743720008474 active site 743720008475 catalytic site [active] 743720008476 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 743720008477 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 743720008478 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 743720008479 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 743720008480 active site 743720008481 catalytic site [active] 743720008482 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720008483 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 743720008484 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 743720008485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720008486 S-adenosylmethionine binding site [chemical binding]; other site 743720008487 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720008488 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 743720008489 active site 743720008490 FOG: CBS domain [General function prediction only]; Region: COG0517 743720008491 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 743720008492 Protein of unknown function DUF72; Region: DUF72; cl00777 743720008493 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 743720008494 putative catalytic site [active] 743720008495 putative metal binding site [ion binding]; other site 743720008496 putative phosphate binding site [ion binding]; other site 743720008497 cardiolipin synthase 2; Provisional; Region: PRK11263 743720008498 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 743720008499 putative active site [active] 743720008500 catalytic site [active] 743720008501 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 743720008502 putative active site [active] 743720008503 catalytic site [active] 743720008504 Predicted integral membrane protein [Function unknown]; Region: COG0392 743720008505 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 743720008506 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 743720008507 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720008508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720008509 DNA-binding site [nucleotide binding]; DNA binding site 743720008510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720008511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720008512 homodimer interface [polypeptide binding]; other site 743720008513 catalytic residue [active] 743720008514 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 743720008515 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 743720008516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720008517 Coenzyme A binding pocket [chemical binding]; other site 743720008518 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 743720008519 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720008520 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720008521 LysE type translocator; Region: LysE; cl00565 743720008522 Cupin domain; Region: Cupin_2; cl09118 743720008523 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720008524 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720008525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720008526 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 743720008527 glycogen branching enzyme; Provisional; Region: PRK05402 743720008528 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 743720008529 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 743720008530 active site 743720008531 catalytic site [active] 743720008532 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 743720008533 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 743720008534 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 743720008535 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 743720008536 active site 743720008537 homodimer interface [polypeptide binding]; other site 743720008538 catalytic site [active] 743720008539 acceptor binding site [chemical binding]; other site 743720008540 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 743720008541 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 743720008542 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 743720008543 active site 743720008544 DNA binding site [nucleotide binding] 743720008545 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 743720008546 DNA binding site [nucleotide binding] 743720008547 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 743720008548 nucleotide binding site [chemical binding]; other site 743720008549 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 743720008550 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 743720008551 putative DNA binding site [nucleotide binding]; other site 743720008552 putative homodimer interface [polypeptide binding]; other site 743720008553 MgtC family; Region: MgtC; pfam02308 743720008554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720008555 NAD(P) binding site [chemical binding]; other site 743720008556 active site 743720008557 hydroperoxidase II; Provisional; Region: katE; PRK11249 743720008558 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 743720008559 tetramer interface [polypeptide binding]; other site 743720008560 heme binding pocket [chemical binding]; other site 743720008561 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 743720008562 domain interactions; other site 743720008563 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 743720008564 homodimer interface [polypeptide binding]; other site 743720008565 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 743720008566 active site pocket [active] 743720008567 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 743720008568 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 743720008569 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 743720008570 Helix-turn-helix domains; Region: HTH; cl00088 743720008571 OsmC-like protein; Region: OsmC; cl00767 743720008572 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 743720008573 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 743720008574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720008575 NAD(P) binding site [chemical binding]; other site 743720008576 active site 743720008577 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 743720008578 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720008579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720008580 Secretin and TonB N terminus short domain; Region: STN; cl06624 743720008581 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 743720008582 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720008583 N-terminal plug; other site 743720008584 ligand-binding site [chemical binding]; other site 743720008585 fec operon regulator FecR; Reviewed; Region: PRK09774 743720008586 FecR protein; Region: FecR; pfam04773 743720008587 RNA polymerase sigma factor; Provisional; Region: PRK12528 743720008588 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720008589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 743720008590 recombination protein RecR; Reviewed; Region: recR; PRK00076 743720008591 RecR protein; Region: RecR; pfam02132 743720008592 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 743720008593 putative active site [active] 743720008594 putative metal-binding site [ion binding]; other site 743720008595 tetramer interface [polypeptide binding]; other site 743720008596 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 743720008597 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 743720008598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720008599 Walker A motif; other site 743720008600 ATP binding site [chemical binding]; other site 743720008601 Walker B motif; other site 743720008602 arginine finger; other site 743720008603 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 743720008604 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 743720008605 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 743720008606 Domain of unknown function (DUF1287); Region: DUF1287; cl01519 743720008607 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 743720008608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720008609 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 743720008610 multidrug efflux protein; Reviewed; Region: PRK01766 743720008611 MatE; Region: MatE; cl10513 743720008612 MatE; Region: MatE; cl10513 743720008613 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 743720008614 CPxP motif; other site 743720008615 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 743720008616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 743720008617 aconitate hydratase; Validated; Region: PRK09277 743720008618 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 743720008619 substrate binding site [chemical binding]; other site 743720008620 ligand binding site [chemical binding]; other site 743720008621 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 743720008622 substrate binding site [chemical binding]; other site 743720008623 PAS domain; Region: PAS_9; pfam13426 743720008624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720008625 putative active site [active] 743720008626 heme pocket [chemical binding]; other site 743720008627 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720008628 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720008629 dimer interface [polypeptide binding]; other site 743720008630 putative CheW interface [polypeptide binding]; other site 743720008631 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 743720008632 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 743720008633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720008634 Coenzyme A binding pocket [chemical binding]; other site 743720008635 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 743720008636 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 743720008637 putative substrate binding pocket [chemical binding]; other site 743720008638 trimer interface [polypeptide binding]; other site 743720008639 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 743720008640 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 743720008641 Low-spin heme binding site [chemical binding]; other site 743720008642 Putative water exit pathway; other site 743720008643 Binuclear center (active site) [active] 743720008644 Putative proton exit pathway; other site 743720008645 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 743720008646 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 743720008647 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 743720008648 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 743720008649 Cytochrome c; Region: Cytochrom_C; cl11414 743720008650 Cytochrome c; Region: Cytochrom_C; cl11414 743720008651 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 743720008652 Low-spin heme binding site [chemical binding]; other site 743720008653 Putative water exit pathway; other site 743720008654 Binuclear center (active site) [active] 743720008655 Putative proton exit pathway; other site 743720008656 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 743720008657 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 743720008658 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 743720008659 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 743720008660 Cytochrome c; Region: Cytochrom_C; cl11414 743720008661 Cytochrome c; Region: Cytochrom_C; cl11414 743720008662 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 743720008663 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 743720008664 4Fe-4S binding domain; Region: Fer4_5; pfam12801 743720008665 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 743720008666 FixH; Region: FixH; cl01254 743720008667 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 743720008668 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 743720008669 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743720008670 metal-binding site [ion binding] 743720008671 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743720008672 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 743720008673 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 743720008674 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 743720008675 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 743720008676 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720008677 FeS/SAM binding site; other site 743720008678 HemN C-terminal domain; Region: HemN_C; pfam06969 743720008679 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 743720008680 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720008681 ligand binding site [chemical binding]; other site 743720008682 flexible hinge region; other site 743720008683 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 743720008684 putative switch regulator; other site 743720008685 non-specific DNA interactions [nucleotide binding]; other site 743720008686 DNA binding site [nucleotide binding] 743720008687 sequence specific DNA binding site [nucleotide binding]; other site 743720008688 putative cAMP binding site [chemical binding]; other site 743720008689 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 743720008690 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720008691 active site 743720008692 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 743720008693 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 743720008694 tandem repeat interface [polypeptide binding]; other site 743720008695 oligomer interface [polypeptide binding]; other site 743720008696 active site residues [active] 743720008697 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 743720008698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720008699 motif II; other site 743720008700 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 743720008701 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720008702 RNA binding surface [nucleotide binding]; other site 743720008703 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 743720008704 active site 743720008705 ribonuclease E; Reviewed; Region: rne; PRK10811 743720008706 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 743720008707 homodimer interface [polypeptide binding]; other site 743720008708 oligonucleotide binding site [chemical binding]; other site 743720008709 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 743720008710 FAD binding domain; Region: FAD_binding_4; pfam01565 743720008711 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 743720008712 Low molecular weight phosphatase family; Region: LMWPc; cd00115 743720008713 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 743720008714 active site 743720008715 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 743720008716 Ligand binding site; other site 743720008717 oligomer interface; other site 743720008718 Trm112p-like protein; Region: Trm112p; cl01066 743720008719 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 743720008720 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 743720008721 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 743720008722 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 743720008723 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 743720008724 Competence protein; Region: Competence; cl00471 743720008725 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 743720008726 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 743720008727 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743720008728 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 743720008729 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 743720008730 Walker A/P-loop; other site 743720008731 ATP binding site [chemical binding]; other site 743720008732 Q-loop/lid; other site 743720008733 ABC transporter signature motif; other site 743720008734 Walker B; other site 743720008735 D-loop; other site 743720008736 H-loop/switch region; other site 743720008737 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 743720008738 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743720008739 FtsX-like permease family; Region: FtsX; cl15850 743720008740 PilZ domain; Region: PilZ; cl01260 743720008741 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 743720008742 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 743720008743 active site 743720008744 catalytic site [active] 743720008745 metal binding site [ion binding]; metal-binding site 743720008746 Predicted kinase [General function prediction only]; Region: COG0645 743720008747 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 743720008748 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720008749 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743720008750 Protein of unknown function (DUF539); Region: DUF539; cl01129 743720008751 ApbE family; Region: ApbE; cl00643 743720008752 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 743720008753 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720008754 catalytic loop [active] 743720008755 iron binding site [ion binding]; other site 743720008756 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 743720008757 FAD binding pocket [chemical binding]; other site 743720008758 FAD binding motif [chemical binding]; other site 743720008759 phosphate binding motif [ion binding]; other site 743720008760 beta-alpha-beta structure motif; other site 743720008761 NAD binding pocket [chemical binding]; other site 743720008762 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 743720008763 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 743720008764 FMN-binding domain; Region: FMN_bind; cl01081 743720008765 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 743720008766 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 743720008767 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 743720008768 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 743720008769 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 743720008770 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 743720008771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720008772 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 743720008773 transcription-repair coupling factor; Provisional; Region: PRK10689 743720008774 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 743720008775 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720008776 ATP binding site [chemical binding]; other site 743720008777 putative Mg++ binding site [ion binding]; other site 743720008778 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720008779 nucleotide binding region [chemical binding]; other site 743720008780 ATP-binding site [chemical binding]; other site 743720008781 TRCF domain; Region: TRCF; cl04088 743720008782 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 743720008783 Helix-turn-helix domains; Region: HTH; cl00088 743720008784 LexA repressor; Validated; Region: PRK00215 743720008785 Helix-turn-helix domains; Region: HTH; cl00088 743720008786 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 743720008787 Catalytic site [active] 743720008788 Cell division inhibitor SulA; Region: SulA; cl01880 743720008789 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 743720008790 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 743720008791 active site 743720008792 interdomain interaction site; other site 743720008793 putative metal-binding site [ion binding]; other site 743720008794 nucleotide binding site [chemical binding]; other site 743720008795 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 743720008796 domain I; other site 743720008797 DNA binding groove [nucleotide binding] 743720008798 phosphate binding site [ion binding]; other site 743720008799 domain II; other site 743720008800 domain III; other site 743720008801 nucleotide binding site [chemical binding]; other site 743720008802 catalytic site [active] 743720008803 domain IV; other site 743720008804 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 743720008805 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 743720008806 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 743720008807 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 743720008808 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 743720008809 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 743720008810 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720008811 dimer interface [polypeptide binding]; other site 743720008812 active site 743720008813 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 743720008814 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720008815 substrate binding site [chemical binding]; other site 743720008816 oxyanion hole (OAH) forming residues; other site 743720008817 trimer interface [polypeptide binding]; other site 743720008818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720008819 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 743720008820 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 743720008821 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720008822 Ligand Binding Site [chemical binding]; other site 743720008823 ABC transporter ATPase component; Reviewed; Region: PRK11147 743720008824 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 743720008825 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 743720008826 ABC transporter; Region: ABC_tran_2; pfam12848 743720008827 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 743720008828 lytic murein transglycosylase; Provisional; Region: PRK11619 743720008829 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 743720008830 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720008831 catalytic residue [active] 743720008832 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 743720008833 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 743720008834 MOSC domain; Region: MOSC; pfam03473 743720008835 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 743720008836 Response regulator receiver domain; Region: Response_reg; pfam00072 743720008837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720008838 active site 743720008839 phosphorylation site [posttranslational modification] 743720008840 intermolecular recognition site; other site 743720008841 dimerization interface [polypeptide binding]; other site 743720008842 lipid kinase; Reviewed; Region: PRK13054 743720008843 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 743720008844 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 743720008845 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 743720008846 dimer interface [polypeptide binding]; other site 743720008847 putative functional site; other site 743720008848 putative MPT binding site; other site 743720008849 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 743720008850 MPT binding site; other site 743720008851 trimer interface [polypeptide binding]; other site 743720008852 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 743720008853 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 743720008854 GTP binding site; other site 743720008855 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 743720008856 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 743720008857 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 743720008858 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 743720008859 sensor protein PhoQ; Provisional; Region: PRK10815 743720008860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720008861 dimer interface [polypeptide binding]; other site 743720008862 phosphorylation site [posttranslational modification] 743720008863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720008864 ATP binding site [chemical binding]; other site 743720008865 G-X-G motif; other site 743720008866 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 743720008867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720008868 active site 743720008869 phosphorylation site [posttranslational modification] 743720008870 intermolecular recognition site; other site 743720008871 dimerization interface [polypeptide binding]; other site 743720008872 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720008873 DNA binding site [nucleotide binding] 743720008874 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 743720008875 NapD protein; Region: NapD; cl01163 743720008876 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 743720008877 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 743720008878 [4Fe-4S] binding site [ion binding]; other site 743720008879 molybdopterin cofactor binding site; other site 743720008880 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 743720008881 molybdopterin cofactor binding site; other site 743720008882 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 743720008883 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 743720008884 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 743720008885 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 743720008886 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 743720008887 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 743720008888 active site 743720008889 metal binding site [ion binding]; metal-binding site 743720008890 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 743720008891 dimer interface [polypeptide binding]; other site 743720008892 active site 743720008893 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 743720008894 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743720008895 LemA family; Region: LemA; cl00742 743720008896 Peptidase family M48; Region: Peptidase_M48; cl12018 743720008897 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 743720008898 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 743720008899 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 743720008900 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 743720008901 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 743720008902 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 743720008903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720008904 Helix-turn-helix domains; Region: HTH; cl00088 743720008905 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720008906 putative effector binding pocket; other site 743720008907 dimerization interface [polypeptide binding]; other site 743720008908 PPIC-type PPIASE domain; Region: Rotamase; cl08278 743720008909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 743720008910 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 743720008911 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 743720008912 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 743720008913 active site 743720008914 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 743720008915 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 743720008916 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 743720008917 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 743720008918 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 743720008919 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720008920 Helix-turn-helix domains; Region: HTH; cl00088 743720008921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720008922 dimerization interface [polypeptide binding]; other site 743720008923 LysE type translocator; Region: LysE; cl00565 743720008924 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 743720008925 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720008926 Transcriptional regulator; Region: Transcrip_reg; cl00361 743720008927 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 743720008928 nudix motif; other site 743720008929 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 743720008930 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720008931 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720008932 metal binding site [ion binding]; metal-binding site 743720008933 active site 743720008934 I-site; other site 743720008935 Sodium:solute symporter family; Region: SSF; cl00456 743720008936 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 743720008937 Protein of unknown function, DUF485; Region: DUF485; cl01231 743720008938 Flavin Reductases; Region: FlaRed; cl00801 743720008939 amidase; Validated; Region: PRK06565 743720008940 Amidase; Region: Amidase; cl11426 743720008941 AzlC protein; Region: AzlC; cl00570 743720008942 Secretin and TonB N terminus short domain; Region: STN; cl06624 743720008943 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743720008944 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720008945 N-terminal plug; other site 743720008946 ligand-binding site [chemical binding]; other site 743720008947 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 743720008948 FecR protein; Region: FecR; pfam04773 743720008949 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720008950 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 743720008951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 743720008952 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 743720008953 putative C-terminal domain interface [polypeptide binding]; other site 743720008954 putative GSH binding site (G-site) [chemical binding]; other site 743720008955 putative dimer interface [polypeptide binding]; other site 743720008956 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 743720008957 putative N-terminal domain interface [polypeptide binding]; other site 743720008958 putative dimer interface [polypeptide binding]; other site 743720008959 putative substrate binding pocket (H-site) [chemical binding]; other site 743720008960 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 743720008961 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743720008962 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743720008963 Sulfatase; Region: Sulfatase; cl10460 743720008964 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720008965 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 743720008966 active site 743720008967 catalytic residues [active] 743720008968 helicase 45; Provisional; Region: PTZ00424 743720008969 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743720008970 ATP binding site [chemical binding]; other site 743720008971 Mg++ binding site [ion binding]; other site 743720008972 motif III; other site 743720008973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720008974 nucleotide binding region [chemical binding]; other site 743720008975 ATP-binding site [chemical binding]; other site 743720008976 Predicted permeases [General function prediction only]; Region: RarD; COG2962 743720008977 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720008978 Helix-turn-helix domains; Region: HTH; cl00088 743720008979 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720008980 dimerization interface [polypeptide binding]; other site 743720008981 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720008982 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720008983 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 743720008984 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 743720008985 substrate binding site [chemical binding]; other site 743720008986 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 743720008987 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720008988 Walker A/P-loop; other site 743720008989 ATP binding site [chemical binding]; other site 743720008990 Q-loop/lid; other site 743720008991 ABC transporter signature motif; other site 743720008992 Walker B; other site 743720008993 D-loop; other site 743720008994 H-loop/switch region; other site 743720008995 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 743720008996 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720008997 Protein of unknown function, DUF482; Region: DUF482; pfam04339 743720008998 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 743720008999 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 743720009000 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 743720009001 dimer interface [polypeptide binding]; other site 743720009002 active site 743720009003 CoA binding pocket [chemical binding]; other site 743720009004 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 743720009005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720009006 NAD(P) binding site [chemical binding]; other site 743720009007 active site 743720009008 Helix-turn-helix domains; Region: HTH; cl00088 743720009009 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 743720009010 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 743720009011 NAD(P) binding site [chemical binding]; other site 743720009012 carboxy-terminal protease; Provisional; Region: PRK11186 743720009013 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 743720009014 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 743720009015 protein binding site [polypeptide binding]; other site 743720009016 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 743720009017 Catalytic dyad [active] 743720009018 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 743720009019 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720009020 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 743720009021 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720009022 metal binding site [ion binding]; metal-binding site 743720009023 active site 743720009024 I-site; other site 743720009025 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 743720009026 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 743720009027 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 743720009028 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 743720009029 Rod binding protein; Region: Rod-binding; cl01626 743720009030 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 743720009031 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720009032 catalytic residue [active] 743720009033 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 743720009034 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 743720009035 Flagellar L-ring protein; Region: FlgH; cl00905 743720009036 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 743720009037 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 743720009038 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 743720009039 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 743720009040 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 743720009041 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 743720009042 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 743720009043 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 743720009044 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 743720009045 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619 743720009046 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 743720009047 FlgD Ig-like domain; Region: FlgD_ig; cl15790 743720009048 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 743720009049 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 743720009050 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 743720009051 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 743720009052 SAF-like; Region: SAF_2; pfam13144 743720009053 SAF domain; Region: SAF; cl00555 743720009054 flagellin; Provisional; Region: PRK12802 743720009055 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 743720009056 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 743720009057 Helix-turn-helix domains; Region: HTH; cl00088 743720009058 DNA binding site [nucleotide binding] 743720009059 hypothetical protein; Validated; Region: PRK06778 743720009060 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 743720009061 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720009062 ligand binding site [chemical binding]; other site 743720009063 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 743720009064 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 743720009065 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 743720009066 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720009067 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720009068 DNA binding residues [nucleotide binding] 743720009069 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 743720009070 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 743720009071 Flagellar protein FliS; Region: FliS; cl00654 743720009072 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 743720009073 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 743720009074 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 743720009075 FlgN protein; Region: FlgN; cl09176 743720009076 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 743720009077 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 743720009078 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720009079 Walker A motif; other site 743720009080 ATP binding site [chemical binding]; other site 743720009081 Walker B motif; other site 743720009082 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 743720009083 Flagellar assembly protein FliH; Region: FliH; pfam02108 743720009084 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 743720009085 FliG C-terminal domain; Region: FliG_C; pfam01706 743720009086 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 743720009087 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 743720009088 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 743720009089 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 743720009090 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720009091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720009092 Walker A motif; other site 743720009093 ATP binding site [chemical binding]; other site 743720009094 Walker B motif; other site 743720009095 arginine finger; other site 743720009096 Helix-turn-helix domains; Region: HTH; cl00088 743720009097 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 743720009098 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 743720009099 FliP family; Region: FliP; cl00593 743720009100 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 743720009101 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 743720009102 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 743720009103 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 743720009104 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 743720009105 FHIPEP family; Region: FHIPEP; pfam00771 743720009106 PilZ domain; Region: PilZ; cl01260 743720009107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720009108 non-specific DNA binding site [nucleotide binding]; other site 743720009109 salt bridge; other site 743720009110 sequence-specific DNA binding site [nucleotide binding]; other site 743720009111 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720009112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 743720009113 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 743720009114 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720009115 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720009116 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 743720009117 Protein export membrane protein; Region: SecD_SecF; cl14618 743720009118 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 743720009119 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720009120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720009121 dimerization interface [polypeptide binding]; other site 743720009122 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720009123 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720009124 dimer interface [polypeptide binding]; other site 743720009125 putative CheW interface [polypeptide binding]; other site 743720009126 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720009127 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 743720009128 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720009129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720009130 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 743720009131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720009132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720009133 oxidoreductase; Validated; Region: PRK05717 743720009134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720009135 NAD(P) binding site [chemical binding]; other site 743720009136 active site 743720009137 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 743720009138 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 743720009139 homodimer interface [polypeptide binding]; other site 743720009140 substrate-cofactor binding pocket; other site 743720009141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720009142 catalytic residue [active] 743720009143 amidophosphoribosyltransferase; Provisional; Region: PRK09246 743720009144 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 743720009145 active site 743720009146 tetramer interface [polypeptide binding]; other site 743720009147 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720009148 active site 743720009149 Colicin V production protein; Region: Colicin_V; cl00567 743720009150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 743720009151 Sporulation related domain; Region: SPOR; cl10051 743720009152 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 743720009153 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743720009154 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 743720009155 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 743720009156 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 743720009157 active site 743720009158 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 743720009159 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 743720009160 dimerization interface 3.5A [polypeptide binding]; other site 743720009161 active site 743720009162 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 743720009163 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 743720009164 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 743720009165 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 743720009166 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 743720009167 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 743720009168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720009169 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 743720009170 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 743720009171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720009172 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 743720009173 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 743720009174 tartrate dehydrogenase; Provisional; Region: PRK08194 743720009175 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 743720009176 substrate binding site [chemical binding]; other site 743720009177 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 743720009178 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 743720009179 substrate binding site [chemical binding]; other site 743720009180 ligand binding site [chemical binding]; other site 743720009181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720009182 Helix-turn-helix domains; Region: HTH; cl00088 743720009183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720009184 dimerization interface [polypeptide binding]; other site 743720009185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720009186 PAS fold; Region: PAS_3; pfam08447 743720009187 putative active site [active] 743720009188 heme pocket [chemical binding]; other site 743720009189 PAS fold; Region: PAS_3; pfam08447 743720009190 PAS domain S-box; Region: sensory_box; TIGR00229 743720009191 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720009192 PAS domain S-box; Region: sensory_box; TIGR00229 743720009193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720009194 putative active site [active] 743720009195 heme pocket [chemical binding]; other site 743720009196 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720009197 metal binding site [ion binding]; metal-binding site 743720009198 active site 743720009199 I-site; other site 743720009200 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720009201 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 743720009202 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 743720009203 putative dimer interface [polypeptide binding]; other site 743720009204 short chain dehydrogenase; Provisional; Region: PRK06123 743720009205 classical (c) SDRs; Region: SDR_c; cd05233 743720009206 NAD(P) binding site [chemical binding]; other site 743720009207 active site 743720009208 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 743720009209 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 743720009210 FMN binding site [chemical binding]; other site 743720009211 active site 743720009212 catalytic residues [active] 743720009213 substrate binding site [chemical binding]; other site 743720009214 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743720009215 active site 743720009216 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 743720009217 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 743720009218 active site 743720009219 HIGH motif; other site 743720009220 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 743720009221 active site 743720009222 KMSKS motif; other site 743720009223 TIR domain; Region: TIR_2; cl15770 743720009224 excinuclease ABC subunit B; Provisional; Region: PRK05298 743720009225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720009226 ATP binding site [chemical binding]; other site 743720009227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720009228 nucleotide binding region [chemical binding]; other site 743720009229 ATP-binding site [chemical binding]; other site 743720009230 Ultra-violet resistance protein B; Region: UvrB; pfam12344 743720009231 UvrB/uvrC motif; Region: UVR; pfam02151 743720009232 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 743720009233 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720009234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720009235 homodimer interface [polypeptide binding]; other site 743720009236 catalytic residue [active] 743720009237 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720009238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720009239 active site 743720009240 phosphorylation site [posttranslational modification] 743720009241 intermolecular recognition site; other site 743720009242 dimerization interface [polypeptide binding]; other site 743720009243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720009244 Walker A motif; other site 743720009245 ATP binding site [chemical binding]; other site 743720009246 Walker B motif; other site 743720009247 arginine finger; other site 743720009248 Helix-turn-helix domains; Region: HTH; cl00088 743720009249 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 743720009250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720009251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720009252 dimer interface [polypeptide binding]; other site 743720009253 phosphorylation site [posttranslational modification] 743720009254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720009255 ATP binding site [chemical binding]; other site 743720009256 Mg2+ binding site [ion binding]; other site 743720009257 G-X-G motif; other site 743720009258 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720009259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 743720009260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720009261 Walker A motif; other site 743720009262 ATP binding site [chemical binding]; other site 743720009263 Walker B motif; other site 743720009264 arginine finger; other site 743720009265 Helix-turn-helix domains; Region: HTH; cl00088 743720009266 Flagellar protein FliS; Region: FliS; cl00654 743720009267 Flagellar protein FliS; Region: FliS; cl00654 743720009268 flagellar capping protein; Reviewed; Region: fliD; PRK08032 743720009269 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 743720009270 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 743720009271 FlaG protein; Region: FlaG; cl00591 743720009272 flagellin; Reviewed; Region: PRK08869 743720009273 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 743720009274 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 743720009275 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 743720009276 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 743720009277 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 743720009278 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 743720009279 Rod binding protein; Region: Rod-binding; cl01626 743720009280 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12712 743720009281 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 743720009282 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 743720009283 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 743720009284 Flagellar L-ring protein; Region: FlgH; cl00905 743720009285 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 743720009286 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 743720009287 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 743720009288 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 743720009289 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 743720009290 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 743720009291 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 743720009292 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 743720009293 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 743720009294 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 743720009295 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 743720009296 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 743720009297 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 743720009298 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 743720009299 FlgD Ig-like domain; Region: FlgD_ig; cl15790 743720009300 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 743720009301 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 743720009302 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 743720009303 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 743720009304 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 743720009305 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 743720009306 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 743720009307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720009308 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 743720009309 Response regulator receiver domain; Region: Response_reg; pfam00072 743720009310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720009311 active site 743720009312 phosphorylation site [posttranslational modification] 743720009313 intermolecular recognition site; other site 743720009314 dimerization interface [polypeptide binding]; other site 743720009315 SAF domain; Region: SAF; cl00555 743720009316 SAF-like; Region: SAF_2; pfam13144 743720009317 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 743720009318 FlgN protein; Region: FlgN; cl09176 743720009319 Flagellar regulator YcgR; Region: YcgR; pfam07317 743720009320 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 743720009321 PilZ domain; Region: PilZ; cl01260 743720009322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720009323 putative MFS family transporter protein; Provisional; Region: PRK03633 743720009324 putative substrate translocation pore; other site 743720009325 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 743720009326 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 743720009327 dimer interface [polypeptide binding]; other site 743720009328 PYR/PP interface [polypeptide binding]; other site 743720009329 TPP binding site [chemical binding]; other site 743720009330 substrate binding site [chemical binding]; other site 743720009331 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 743720009332 TPP-binding site; other site 743720009333 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 743720009334 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743720009335 Helix-turn-helix domains; Region: HTH; cl00088 743720009336 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 743720009337 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720009338 active site 743720009339 Arc-like DNA binding domain; Region: Arc; pfam03869 743720009340 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 743720009341 MgtE intracellular N domain; Region: MgtE_N; cl15244 743720009342 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 743720009343 Divalent cation transporter; Region: MgtE; cl00786 743720009344 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720009345 Global regulator protein family; Region: CsrA; cl00670 743720009346 aspartate kinase; Reviewed; Region: PRK06635 743720009347 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 743720009348 putative nucleotide binding site [chemical binding]; other site 743720009349 putative catalytic residues [active] 743720009350 putative Mg ion binding site [ion binding]; other site 743720009351 putative aspartate binding site [chemical binding]; other site 743720009352 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 743720009353 putative allosteric regulatory site; other site 743720009354 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 743720009355 putative allosteric regulatory residue; other site 743720009356 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 743720009357 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 743720009358 motif 1; other site 743720009359 active site 743720009360 motif 2; other site 743720009361 motif 3; other site 743720009362 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 743720009363 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 743720009364 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 743720009365 tetramer interface [polypeptide binding]; other site 743720009366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720009367 catalytic residue [active] 743720009368 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 743720009369 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 743720009370 putative active site [active] 743720009371 Zn binding site [ion binding]; other site 743720009372 Succinylarginine dihydrolase; Region: AstB; cl01511 743720009373 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720009374 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 743720009375 NAD(P) binding site [chemical binding]; other site 743720009376 catalytic residues [active] 743720009377 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 743720009378 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 743720009379 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 743720009380 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720009381 inhibitor-cofactor binding pocket; inhibition site 743720009382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720009383 catalytic residue [active] 743720009384 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 743720009385 FMN binding site [chemical binding]; other site 743720009386 substrate binding site [chemical binding]; other site 743720009387 putative catalytic residue [active] 743720009388 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 743720009389 EamA-like transporter family; Region: EamA; cl01037 743720009390 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 743720009391 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 743720009392 glucose-1-dehydrogenase; Provisional; Region: PRK08936 743720009393 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 743720009394 NAD binding site [chemical binding]; other site 743720009395 homodimer interface [polypeptide binding]; other site 743720009396 active site 743720009397 Competence-damaged protein; Region: CinA; cl00666 743720009398 thiamine pyrophosphate protein; Provisional; Region: PRK08273 743720009399 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 743720009400 PYR/PP interface [polypeptide binding]; other site 743720009401 tetramer interface [polypeptide binding]; other site 743720009402 dimer interface [polypeptide binding]; other site 743720009403 TPP binding site [chemical binding]; other site 743720009404 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 743720009405 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 743720009406 TPP-binding site [chemical binding]; other site 743720009407 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 743720009408 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 743720009409 Putative exonuclease, RdgC; Region: RdgC; cl01122 743720009410 bile acid transporter; Region: bass; TIGR00841 743720009411 Membrane transport protein; Region: Mem_trans; cl09117 743720009412 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 743720009413 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720009414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720009415 putative substrate translocation pore; other site 743720009416 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743720009417 putative acyl-acceptor binding pocket; other site 743720009418 transcriptional regulator; Provisional; Region: PRK10632 743720009419 Helix-turn-helix domains; Region: HTH; cl00088 743720009420 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 743720009421 putative effector binding pocket; other site 743720009422 putative dimerization interface [polypeptide binding]; other site 743720009423 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 743720009424 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 743720009425 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 743720009426 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 743720009427 FAD binding pocket [chemical binding]; other site 743720009428 FAD binding motif [chemical binding]; other site 743720009429 phosphate binding motif [ion binding]; other site 743720009430 beta-alpha-beta structure motif; other site 743720009431 NAD binding pocket [chemical binding]; other site 743720009432 Heme binding pocket [chemical binding]; other site 743720009433 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720009434 catalytic loop [active] 743720009435 iron binding site [ion binding]; other site 743720009436 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720009437 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 743720009438 putative C-terminal domain interface [polypeptide binding]; other site 743720009439 putative GSH binding site (G-site) [chemical binding]; other site 743720009440 putative dimer interface [polypeptide binding]; other site 743720009441 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 743720009442 putative N-terminal domain interface [polypeptide binding]; other site 743720009443 putative dimer interface [polypeptide binding]; other site 743720009444 putative substrate binding pocket (H-site) [chemical binding]; other site 743720009445 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 743720009446 AzlC protein; Region: AzlC; cl00570 743720009447 Cupin domain; Region: Cupin_2; cl09118 743720009448 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720009449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720009450 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 743720009451 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720009452 Sodium:solute symporter family; Region: SSF; cl00456 743720009453 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720009454 PAS fold; Region: PAS_7; pfam12860 743720009455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 743720009456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720009457 ATP binding site [chemical binding]; other site 743720009458 Mg2+ binding site [ion binding]; other site 743720009459 G-X-G motif; other site 743720009460 Response regulator receiver domain; Region: Response_reg; pfam00072 743720009461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720009462 active site 743720009463 phosphorylation site [posttranslational modification] 743720009464 intermolecular recognition site; other site 743720009465 dimerization interface [polypeptide binding]; other site 743720009466 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 743720009467 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 743720009468 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 743720009469 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 743720009470 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 743720009471 RmuC family; Region: RmuC; pfam02646 743720009472 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 743720009473 Dicarboxylate transport; Region: DctA-YdbH; cl14674 743720009474 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 743720009475 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 743720009476 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 743720009477 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720009478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720009479 DNA-binding site [nucleotide binding]; DNA binding site 743720009480 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720009481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720009482 homodimer interface [polypeptide binding]; other site 743720009483 catalytic residue [active] 743720009484 RNA polymerase sigma factor; Provisional; Region: PRK12528 743720009485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720009486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 743720009487 fec operon regulator FecR; Reviewed; Region: PRK09774 743720009488 FecR protein; Region: FecR; pfam04773 743720009489 Secretin and TonB N terminus short domain; Region: STN; cl06624 743720009490 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 743720009491 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720009492 N-terminal plug; other site 743720009493 ligand-binding site [chemical binding]; other site 743720009494 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720009495 dimerization interface [polypeptide binding]; other site 743720009496 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720009497 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720009498 dimer interface [polypeptide binding]; other site 743720009499 putative CheW interface [polypeptide binding]; other site 743720009500 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720009501 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 743720009502 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720009503 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720009504 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720009505 dimer interface [polypeptide binding]; other site 743720009506 putative CheW interface [polypeptide binding]; other site 743720009507 putative S-transferase; Provisional; Region: PRK11752 743720009508 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 743720009509 C-terminal domain interface [polypeptide binding]; other site 743720009510 GSH binding site (G-site) [chemical binding]; other site 743720009511 dimer interface [polypeptide binding]; other site 743720009512 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 743720009513 dimer interface [polypeptide binding]; other site 743720009514 N-terminal domain interface [polypeptide binding]; other site 743720009515 active site 743720009516 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 743720009517 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 743720009518 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 743720009519 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720009520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 743720009521 NMT1-like family; Region: NMT1_2; cl15260 743720009522 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720009523 Helix-turn-helix domains; Region: HTH; cl00088 743720009524 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720009525 dimerization interface [polypeptide binding]; other site 743720009526 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 743720009527 homotrimer interaction site [polypeptide binding]; other site 743720009528 putative active site [active] 743720009529 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 743720009530 Isochorismatase family; Region: Isochorismatase; pfam00857 743720009531 catalytic triad [active] 743720009532 dimer interface [polypeptide binding]; other site 743720009533 conserved cis-peptide bond; other site 743720009534 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720009535 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720009536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720009537 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 743720009538 Cell division inhibitor SulA; Region: SulA; cl01880 743720009539 DNA Polymerase Y-family; Region: PolY_like; cd03468 743720009540 active site 743720009541 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 743720009542 DNA binding site [nucleotide binding] 743720009543 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 743720009544 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 743720009545 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 743720009546 generic binding surface I; other site 743720009547 generic binding surface II; other site 743720009548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720009549 Coenzyme A binding pocket [chemical binding]; other site 743720009550 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 743720009551 apolar tunnel; other site 743720009552 heme binding site [chemical binding]; other site 743720009553 dimerization interface [polypeptide binding]; other site 743720009554 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 743720009555 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720009556 dimerization interface [polypeptide binding]; other site 743720009557 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720009558 metal binding site [ion binding]; metal-binding site 743720009559 active site 743720009560 I-site; other site 743720009561 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720009562 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 743720009563 Cupin domain; Region: Cupin_2; cl09118 743720009564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720009565 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720009566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720009567 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 743720009568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720009569 Walker A motif; other site 743720009570 ATP binding site [chemical binding]; other site 743720009571 Walker B motif; other site 743720009572 arginine finger; other site 743720009573 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 743720009574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720009575 putative substrate translocation pore; other site 743720009576 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720009577 OpgC protein; Region: OpgC_C; cl00792 743720009578 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 743720009579 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 743720009580 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 743720009581 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 743720009582 Ligand binding site; other site 743720009583 DXD motif; other site 743720009584 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 743720009585 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 743720009586 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 743720009587 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 743720009588 dimerization interface [polypeptide binding]; other site 743720009589 ligand binding site [chemical binding]; other site 743720009590 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 743720009591 TM-ABC transporter signature motif; other site 743720009592 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 743720009593 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 743720009594 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 743720009595 TM-ABC transporter signature motif; other site 743720009596 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 743720009597 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 743720009598 Walker A/P-loop; other site 743720009599 ATP binding site [chemical binding]; other site 743720009600 Q-loop/lid; other site 743720009601 ABC transporter signature motif; other site 743720009602 Walker B; other site 743720009603 D-loop; other site 743720009604 H-loop/switch region; other site 743720009605 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 743720009606 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 743720009607 Walker A/P-loop; other site 743720009608 ATP binding site [chemical binding]; other site 743720009609 Q-loop/lid; other site 743720009610 ABC transporter signature motif; other site 743720009611 Walker B; other site 743720009612 D-loop; other site 743720009613 H-loop/switch region; other site 743720009614 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 743720009615 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720009616 RNA binding surface [nucleotide binding]; other site 743720009617 PSSA_1: Pseudouridine synthase, a subgroup of the RsuA family. This group is comprised of bacterial proteins assigned to the RsuA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSSA_1; cd02555 743720009618 active site 743720009619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 743720009620 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 743720009621 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 743720009622 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 743720009623 homodimer interaction site [polypeptide binding]; other site 743720009624 cofactor binding site; other site 743720009625 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 743720009626 putative GSH binding site [chemical binding]; other site 743720009627 catalytic residues [active] 743720009628 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 743720009629 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 743720009630 putative [Fe4-S4] binding site [ion binding]; other site 743720009631 putative molybdopterin cofactor binding site [chemical binding]; other site 743720009632 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 743720009633 putative molybdopterin cofactor binding site; other site 743720009634 ornithine carbamoyltransferase; Provisional; Region: PRK00779 743720009635 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 743720009636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720009637 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 743720009638 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 743720009639 Walker A/P-loop; other site 743720009640 ATP binding site [chemical binding]; other site 743720009641 Q-loop/lid; other site 743720009642 ABC transporter signature motif; other site 743720009643 Walker B; other site 743720009644 D-loop; other site 743720009645 H-loop/switch region; other site 743720009646 TOBE domain; Region: TOBE_2; cl01440 743720009647 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 743720009648 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 743720009649 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 743720009650 substrate binding pocket [chemical binding]; other site 743720009651 membrane-bound complex binding site; other site 743720009652 hinge residues; other site 743720009653 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 743720009654 putative deacylase active site [active] 743720009655 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 743720009656 amphipathic channel; other site 743720009657 Asn-Pro-Ala signature motifs; other site 743720009658 glycerol kinase; Provisional; Region: glpK; PRK00047 743720009659 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 743720009660 N- and C-terminal domain interface [polypeptide binding]; other site 743720009661 active site 743720009662 MgATP binding site [chemical binding]; other site 743720009663 catalytic site [active] 743720009664 metal binding site [ion binding]; metal-binding site 743720009665 glycerol binding site [chemical binding]; other site 743720009666 homotetramer interface [polypeptide binding]; other site 743720009667 homodimer interface [polypeptide binding]; other site 743720009668 FBP binding site [chemical binding]; other site 743720009669 protein IIAGlc interface [polypeptide binding]; other site 743720009670 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 743720009671 Helix-turn-helix domains; Region: HTH; cl00088 743720009672 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 743720009673 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 743720009674 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 743720009675 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720009676 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 743720009677 Helix-turn-helix domains; Region: HTH; cl00088 743720009678 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 743720009679 putative dimerization interface [polypeptide binding]; other site 743720009680 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 743720009681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720009682 S-adenosylmethionine binding site [chemical binding]; other site 743720009683 Methyltransferase domain; Region: Methyltransf_31; pfam13847 743720009684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720009685 S-adenosylmethionine binding site [chemical binding]; other site 743720009686 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 743720009687 active site 743720009688 hydrophilic channel; other site 743720009689 dimerization interface [polypeptide binding]; other site 743720009690 catalytic residues [active] 743720009691 active site lid [active] 743720009692 Recombination protein O N terminal; Region: RecO_N; cl15812 743720009693 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 743720009694 Recombination protein O C terminal; Region: RecO_C; pfam02565 743720009695 GTPase Era; Reviewed; Region: era; PRK00089 743720009696 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 743720009697 G1 box; other site 743720009698 GTP/Mg2+ binding site [chemical binding]; other site 743720009699 Switch I region; other site 743720009700 G2 box; other site 743720009701 Switch II region; other site 743720009702 G3 box; other site 743720009703 G4 box; other site 743720009704 G5 box; other site 743720009705 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 743720009706 ribonuclease III; Reviewed; Region: rnc; PRK00102 743720009707 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 743720009708 dimerization interface [polypeptide binding]; other site 743720009709 active site 743720009710 metal binding site [ion binding]; metal-binding site 743720009711 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 743720009712 dsRNA binding site [nucleotide binding]; other site 743720009713 signal peptidase I; Provisional; Region: PRK10861 743720009714 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 743720009715 Catalytic site [active] 743720009716 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 743720009717 GTP-binding protein LepA; Provisional; Region: PRK05433 743720009718 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 743720009719 G1 box; other site 743720009720 putative GEF interaction site [polypeptide binding]; other site 743720009721 GTP/Mg2+ binding site [chemical binding]; other site 743720009722 Switch I region; other site 743720009723 G2 box; other site 743720009724 G3 box; other site 743720009725 Switch II region; other site 743720009726 G4 box; other site 743720009727 G5 box; other site 743720009728 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 743720009729 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 743720009730 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 743720009731 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 743720009732 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 743720009733 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743720009734 protein binding site [polypeptide binding]; other site 743720009735 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743720009736 protein binding site [polypeptide binding]; other site 743720009737 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 743720009738 MucB/RseB family; Region: MucB_RseB; pfam03888 743720009739 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 743720009740 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 743720009741 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 743720009742 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 743720009743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720009744 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720009745 DNA binding residues [nucleotide binding] 743720009746 L-aspartate oxidase; Provisional; Region: PRK09077 743720009747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720009748 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 743720009749 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 743720009750 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 743720009751 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 743720009752 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 743720009753 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 743720009754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720009755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720009756 dimer interface [polypeptide binding]; other site 743720009757 phosphorylation site [posttranslational modification] 743720009758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720009759 ATP binding site [chemical binding]; other site 743720009760 Mg2+ binding site [ion binding]; other site 743720009761 G-X-G motif; other site 743720009762 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 743720009763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720009764 active site 743720009765 phosphorylation site [posttranslational modification] 743720009766 intermolecular recognition site; other site 743720009767 dimerization interface [polypeptide binding]; other site 743720009768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720009769 DNA binding site [nucleotide binding] 743720009770 outer membrane porin, OprD family; Region: OprD; pfam03573 743720009771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 743720009772 NMT1-like family; Region: NMT1_2; cl15260 743720009773 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720009774 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 743720009775 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 743720009776 Putative ammonia monooxygenase; Region: AmoA; pfam05145 743720009777 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 743720009778 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 743720009779 ligand binding site [chemical binding]; other site 743720009780 active site 743720009781 UGI interface [polypeptide binding]; other site 743720009782 catalytic site [active] 743720009783 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 743720009784 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 743720009785 enoyl-CoA hydratase; Provisional; Region: PRK09076 743720009786 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720009787 substrate binding site [chemical binding]; other site 743720009788 oxyanion hole (OAH) forming residues; other site 743720009789 trimer interface [polypeptide binding]; other site 743720009790 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 743720009791 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720009792 substrate binding site [chemical binding]; other site 743720009793 oxyanion hole (OAH) forming residues; other site 743720009794 trimer interface [polypeptide binding]; other site 743720009795 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 743720009796 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 743720009797 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720009798 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720009799 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 743720009800 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421 743720009801 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 743720009802 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 743720009803 Walker A/P-loop; other site 743720009804 ATP binding site [chemical binding]; other site 743720009805 Q-loop/lid; other site 743720009806 ABC transporter signature motif; other site 743720009807 Walker B; other site 743720009808 D-loop; other site 743720009809 H-loop/switch region; other site 743720009810 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 743720009811 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 743720009812 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720009813 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 743720009814 PA14 domain; Region: PA14; cl08459 743720009815 Calx-beta domain; Region: Calx-beta; cl02522 743720009816 Calx-beta domain; Region: Calx-beta; cl02522 743720009817 Calx-beta domain; Region: Calx-beta; cl02522 743720009818 Calx-beta domain; Region: Calx-beta; cl02522 743720009819 Calx-beta domain; Region: Calx-beta; cl02522 743720009820 Calx-beta domain; Region: Calx-beta; cl02522 743720009821 Calx-beta domain; Region: Calx-beta; cl02522 743720009822 Calx-beta domain; Region: Calx-beta; cl02522 743720009823 PA14 domain; Region: PA14; cl08459 743720009824 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 743720009825 metal ion-dependent adhesion site (MIDAS); other site 743720009826 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 743720009827 type 1 secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 743720009828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720009829 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720009830 metal binding site [ion binding]; metal-binding site 743720009831 active site 743720009832 I-site; other site 743720009833 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720009834 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 743720009835 NMT1-like family; Region: NMT1_2; cl15260 743720009836 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 743720009837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743720009838 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 743720009839 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 743720009840 Walker A/P-loop; other site 743720009841 ATP binding site [chemical binding]; other site 743720009842 Q-loop/lid; other site 743720009843 ABC transporter signature motif; other site 743720009844 Walker B; other site 743720009845 D-loop; other site 743720009846 H-loop/switch region; other site 743720009847 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 743720009848 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 743720009849 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 743720009850 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 743720009851 urea carboxylase; Region: urea_carbox; TIGR02712 743720009852 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720009853 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720009854 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 743720009855 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 743720009856 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 743720009857 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743720009858 carboxyltransferase (CT) interaction site; other site 743720009859 biotinylation site [posttranslational modification]; other site 743720009860 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 743720009861 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720009862 metal binding site [ion binding]; metal-binding site 743720009863 active site 743720009864 I-site; other site 743720009865 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 743720009866 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 743720009867 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720009868 RNA binding surface [nucleotide binding]; other site 743720009869 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 743720009870 active site 743720009871 uracil binding [chemical binding]; other site 743720009872 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720009873 TIR domain; Region: TIR_2; cl15770 743720009874 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 743720009875 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 743720009876 intersubunit interface [polypeptide binding]; other site 743720009877 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 743720009878 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720009879 ABC-ATPase subunit interface; other site 743720009880 dimer interface [polypeptide binding]; other site 743720009881 putative PBP binding regions; other site 743720009882 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 743720009883 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 743720009884 Walker A/P-loop; other site 743720009885 ATP binding site [chemical binding]; other site 743720009886 Q-loop/lid; other site 743720009887 ABC transporter signature motif; other site 743720009888 Walker B; other site 743720009889 D-loop; other site 743720009890 H-loop/switch region; other site 743720009891 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743720009892 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720009893 N-terminal plug; other site 743720009894 ligand-binding site [chemical binding]; other site 743720009895 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 743720009896 potential catalytic triad [active] 743720009897 conserved cys residue [active] 743720009898 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 743720009899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720009900 dimerization interface [polypeptide binding]; other site 743720009901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720009902 dimer interface [polypeptide binding]; other site 743720009903 phosphorylation site [posttranslational modification] 743720009904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720009905 ATP binding site [chemical binding]; other site 743720009906 G-X-G motif; other site 743720009907 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720009908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720009909 active site 743720009910 phosphorylation site [posttranslational modification] 743720009911 intermolecular recognition site; other site 743720009912 dimerization interface [polypeptide binding]; other site 743720009913 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720009914 DNA binding site [nucleotide binding] 743720009915 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 743720009916 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720009917 N-terminal plug; other site 743720009918 ligand-binding site [chemical binding]; other site 743720009919 GTP-binding protein Der; Reviewed; Region: PRK00093 743720009920 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 743720009921 G1 box; other site 743720009922 GTP/Mg2+ binding site [chemical binding]; other site 743720009923 Switch I region; other site 743720009924 G2 box; other site 743720009925 Switch II region; other site 743720009926 G3 box; other site 743720009927 G4 box; other site 743720009928 G5 box; other site 743720009929 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 743720009930 G1 box; other site 743720009931 GTP/Mg2+ binding site [chemical binding]; other site 743720009932 Switch I region; other site 743720009933 G2 box; other site 743720009934 G3 box; other site 743720009935 Switch II region; other site 743720009936 G4 box; other site 743720009937 G5 box; other site 743720009938 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 743720009939 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 743720009940 Trp docking motif [polypeptide binding]; other site 743720009941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 743720009942 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 743720009943 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 743720009944 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 743720009945 dimer interface [polypeptide binding]; other site 743720009946 motif 1; other site 743720009947 active site 743720009948 motif 2; other site 743720009949 motif 3; other site 743720009950 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 743720009951 anticodon binding site; other site 743720009952 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 743720009953 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 743720009954 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 743720009955 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 743720009956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720009957 non-specific DNA binding site [nucleotide binding]; other site 743720009958 salt bridge; other site 743720009959 sequence-specific DNA binding site [nucleotide binding]; other site 743720009960 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 743720009961 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 743720009962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720009963 binding surface 743720009964 TPR motif; other site 743720009965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720009966 binding surface 743720009967 TPR motif; other site 743720009968 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 743720009969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720009970 FeS/SAM binding site; other site 743720009971 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 743720009972 active site 743720009973 multimer interface [polypeptide binding]; other site 743720009974 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 743720009975 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720009976 catalytic loop [active] 743720009977 iron binding site [ion binding]; other site 743720009978 chaperone protein HscA; Provisional; Region: hscA; PRK05183 743720009979 co-chaperone HscB; Provisional; Region: hscB; PRK00294 743720009980 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743720009981 HSP70 interaction site [polypeptide binding]; other site 743720009982 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 743720009983 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 743720009984 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 743720009985 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 743720009986 trimerization site [polypeptide binding]; other site 743720009987 active site 743720009988 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 743720009989 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 743720009990 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720009991 catalytic residue [active] 743720009992 Helix-turn-helix domains; Region: HTH; cl00088 743720009993 Rrf2 family protein; Region: rrf2_super; TIGR00738 743720009994 serine O-acetyltransferase; Region: cysE; TIGR01172 743720009995 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 743720009996 trimer interface [polypeptide binding]; other site 743720009997 active site 743720009998 substrate binding site [chemical binding]; other site 743720009999 CoA binding site [chemical binding]; other site 743720010000 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 743720010001 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 743720010002 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 743720010003 active site 743720010004 dimerization interface [polypeptide binding]; other site 743720010005 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 743720010006 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 743720010007 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 743720010008 Protein export membrane protein; Region: SecD_SecF; cl14618 743720010009 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 743720010010 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 743720010011 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 743720010012 Protein export membrane protein; Region: SecD_SecF; cl14618 743720010013 Preprotein translocase subunit; Region: YajC; cl00806 743720010014 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 743720010015 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 743720010016 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 743720010017 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 743720010018 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 743720010019 DNA-binding site [nucleotide binding]; DNA binding site 743720010020 RNA-binding motif; other site 743720010021 RDD family; Region: RDD; cl00746 743720010022 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 743720010023 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 743720010024 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 743720010025 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 743720010026 multifunctional aminopeptidase A; Provisional; Region: PRK00913 743720010027 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 743720010028 interface (dimer of trimers) [polypeptide binding]; other site 743720010029 Substrate-binding/catalytic site; other site 743720010030 Zn-binding sites [ion binding]; other site 743720010031 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 743720010032 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 743720010033 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 743720010034 HIGH motif; other site 743720010035 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 743720010036 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 743720010037 active site 743720010038 KMSKS motif; other site 743720010039 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 743720010040 tRNA binding surface [nucleotide binding]; other site 743720010041 anticodon binding site; other site 743720010042 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 743720010043 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 743720010044 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 743720010045 transmembrane helices; other site 743720010046 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 743720010047 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 743720010048 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 743720010049 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 743720010050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720010051 S-adenosylmethionine binding site [chemical binding]; other site 743720010052 Protein of unknown function (DUF998); Region: DUF998; pfam06197 743720010053 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 743720010054 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 743720010055 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 743720010056 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 743720010057 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 743720010058 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 743720010059 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 743720010060 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 743720010061 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 743720010062 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 743720010063 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 743720010064 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 743720010065 Glycerate kinase family; Region: Gly_kinase; cl00841 743720010066 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 743720010067 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 743720010068 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 743720010069 Helix-turn-helix domains; Region: HTH; cl00088 743720010070 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 743720010071 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 743720010072 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 743720010073 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720010074 ligand binding site [chemical binding]; other site 743720010075 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720010076 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 743720010077 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720010078 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720010079 Copper resistance protein D; Region: CopD; cl00563 743720010080 Protein of unknown function (DUF1145); Region: DUF1145; cl11481 743720010081 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720010082 ligand binding site [chemical binding]; other site 743720010083 hypothetical protein; Provisional; Region: PRK00183 743720010084 SEC-C motif; Region: SEC-C; pfam02810 743720010085 LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608 743720010086 Late embryogenesis abundant protein; Region: LEA_2; cl12118 743720010087 SEC-C motif; Region: SEC-C; pfam02810 743720010088 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 743720010089 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 743720010090 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 743720010091 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 743720010092 active site 743720010093 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 743720010094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720010095 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 743720010096 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 743720010097 [4Fe-4S] binding site [ion binding]; other site 743720010098 molybdopterin cofactor binding site; other site 743720010099 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 743720010100 molybdopterin cofactor binding site; other site 743720010101 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 743720010102 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 743720010103 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 743720010104 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 743720010105 Nitrate and nitrite sensing; Region: NIT; pfam08376 743720010106 ANTAR domain; Region: ANTAR; cl04297 743720010107 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 743720010108 NMT1-like family; Region: NMT1_2; cl15260 743720010109 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 743720010110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720010111 dimer interface [polypeptide binding]; other site 743720010112 conserved gate region; other site 743720010113 putative PBP binding loops; other site 743720010114 ABC-ATPase subunit interface; other site 743720010115 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 743720010116 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 743720010117 Walker A/P-loop; other site 743720010118 ATP binding site [chemical binding]; other site 743720010119 Q-loop/lid; other site 743720010120 ABC transporter signature motif; other site 743720010121 Walker B; other site 743720010122 D-loop; other site 743720010123 H-loop/switch region; other site 743720010124 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 743720010125 trimer interface [polypeptide binding]; other site 743720010126 active site 743720010127 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 743720010128 DNA-binding site [nucleotide binding]; DNA binding site 743720010129 RNA-binding motif; other site 743720010130 antiporter inner membrane protein; Provisional; Region: PRK11670 743720010131 Domain of unknown function DUF59; Region: DUF59; cl00941 743720010132 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 743720010133 Walker A motif; other site 743720010134 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720010135 ligand binding site [chemical binding]; other site 743720010136 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 743720010137 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 743720010138 active site 743720010139 HIGH motif; other site 743720010140 KMSKS motif; other site 743720010141 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 743720010142 tRNA binding surface [nucleotide binding]; other site 743720010143 anticodon binding site; other site 743720010144 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 743720010145 putative tRNA-binding site [nucleotide binding]; other site 743720010146 dimer interface [polypeptide binding]; other site 743720010147 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 743720010148 electron transport complex protein RnfB; Provisional; Region: PRK05113 743720010149 Putative Fe-S cluster; Region: FeS; pfam04060 743720010150 4Fe-4S binding domain; Region: Fer4; cl02805 743720010151 endonuclease III; Provisional; Region: PRK10702 743720010152 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743720010153 minor groove reading motif; other site 743720010154 helix-hairpin-helix signature motif; other site 743720010155 substrate binding pocket [chemical binding]; other site 743720010156 active site 743720010157 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 743720010158 thioredoxin reductase; Provisional; Region: PRK10262 743720010159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720010160 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 743720010161 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 743720010162 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743720010163 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 743720010164 catalytic residues [active] 743720010165 dimer interface [polypeptide binding]; other site 743720010166 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 743720010167 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 743720010168 Acetokinase family; Region: Acetate_kinase; cl01029 743720010169 propionate/acetate kinase; Provisional; Region: PRK12379 743720010170 phosphate acetyltransferase; Reviewed; Region: PRK05632 743720010171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720010172 DRTGG domain; Region: DRTGG; cl12147 743720010173 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 743720010174 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743720010175 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 743720010176 putative acyl-acceptor binding pocket; other site 743720010177 response regulator PleD; Reviewed; Region: pleD; PRK09581 743720010178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720010179 active site 743720010180 phosphorylation site [posttranslational modification] 743720010181 intermolecular recognition site; other site 743720010182 dimerization interface [polypeptide binding]; other site 743720010183 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720010184 putative active site [active] 743720010185 heme pocket [chemical binding]; other site 743720010186 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720010187 metal binding site [ion binding]; metal-binding site 743720010188 active site 743720010189 I-site; other site 743720010190 putative outer membrane lipoprotein; Provisional; Region: PRK10510 743720010191 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720010192 ligand binding site [chemical binding]; other site 743720010193 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 743720010194 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 743720010195 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 743720010196 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 743720010197 AMP-binding enzyme; Region: AMP-binding; cl15778 743720010198 AMP-binding enzyme; Region: AMP-binding; cl15778 743720010199 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 743720010200 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720010201 dimer interface [polypeptide binding]; other site 743720010202 active site 743720010203 LysE type translocator; Region: LysE; cl00565 743720010204 glycerate dehydrogenase; Provisional; Region: PRK06487 743720010205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720010206 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 743720010207 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 743720010208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 743720010209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720010210 S-adenosylmethionine binding site [chemical binding]; other site 743720010211 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 743720010212 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 743720010213 Peptidase family M48; Region: Peptidase_M48; cl12018 743720010214 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 743720010215 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 743720010216 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 743720010217 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720010218 putative acyl-acceptor binding pocket; other site 743720010219 hypothetical protein; Provisional; Region: PRK11627 743720010220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720010221 Predicted dehydrogenase [General function prediction only]; Region: COG0579 743720010222 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 743720010223 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 743720010224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720010225 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 743720010226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720010227 DNA binding residues [nucleotide binding] 743720010228 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 743720010229 putative peptidoglycan binding site; other site 743720010230 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 743720010231 Domain of unknown function (DUF368); Region: DUF368; cl00893 743720010232 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 743720010233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720010234 S-adenosylmethionine binding site [chemical binding]; other site 743720010235 Survival protein SurE; Region: SurE; cl00448 743720010236 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 743720010237 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 743720010238 Permutation of conserved domain; other site 743720010239 active site 743720010240 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 743720010241 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 743720010242 homotrimer interaction site [polypeptide binding]; other site 743720010243 zinc binding site [ion binding]; other site 743720010244 CDP-binding sites; other site 743720010245 Ferritin-like domain; Region: Ferritin; pfam00210 743720010246 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 743720010247 dimerization interface [polypeptide binding]; other site 743720010248 DPS ferroxidase diiron center [ion binding]; other site 743720010249 ion pore; other site 743720010250 Predicted esterase [General function prediction only]; Region: COG0627 743720010251 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720010252 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 743720010253 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 743720010254 substrate binding site [chemical binding]; other site 743720010255 catalytic Zn binding site [ion binding]; other site 743720010256 NAD binding site [chemical binding]; other site 743720010257 structural Zn binding site [ion binding]; other site 743720010258 dimer interface [polypeptide binding]; other site 743720010259 LysR family transcriptional regulator; Provisional; Region: PRK14997 743720010260 Helix-turn-helix domains; Region: HTH; cl00088 743720010261 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720010262 dimerization interface [polypeptide binding]; other site 743720010263 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 743720010264 30S subunit binding site; other site 743720010265 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 743720010266 substrate binding site; other site 743720010267 dimer interface; other site 743720010268 Septum formation initiator; Region: DivIC; cl11433 743720010269 enolase; Provisional; Region: eno; PRK00077 743720010270 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 743720010271 dimer interface [polypeptide binding]; other site 743720010272 metal binding site [ion binding]; metal-binding site 743720010273 substrate binding pocket [chemical binding]; other site 743720010274 NeuB family; Region: NeuB; cl00496 743720010275 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 743720010276 CTP synthetase; Validated; Region: pyrG; PRK05380 743720010277 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 743720010278 Catalytic site [active] 743720010279 active site 743720010280 UTP binding site [chemical binding]; other site 743720010281 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 743720010282 active site 743720010283 putative oxyanion hole; other site 743720010284 catalytic triad [active] 743720010285 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 743720010286 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 743720010287 Ligand Binding Site [chemical binding]; other site 743720010288 TilS substrate binding domain; Region: TilS; pfam09179 743720010289 B3/4 domain; Region: B3_4; cl11458 743720010290 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 743720010291 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 743720010292 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 743720010293 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 743720010294 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 743720010295 generic binding surface II; other site 743720010296 generic binding surface I; other site 743720010297 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 743720010298 RNA/DNA hybrid binding site [nucleotide binding]; other site 743720010299 active site 743720010300 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 743720010301 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743720010302 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 743720010303 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 743720010304 active site 743720010305 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 743720010306 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 743720010307 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 743720010308 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 743720010309 trimer interface [polypeptide binding]; other site 743720010310 active site 743720010311 UDP-GlcNAc binding site [chemical binding]; other site 743720010312 lipid binding site [chemical binding]; lipid-binding site 743720010313 periplasmic chaperone; Provisional; Region: PRK10780 743720010314 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 743720010315 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 743720010316 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 743720010317 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 743720010318 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 743720010319 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 743720010320 Surface antigen; Region: Bac_surface_Ag; cl03097 743720010321 zinc metallopeptidase RseP; Provisional; Region: PRK10779 743720010322 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 743720010323 active site 743720010324 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 743720010325 protein binding site [polypeptide binding]; other site 743720010326 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 743720010327 protein binding site [polypeptide binding]; other site 743720010328 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 743720010329 putative substrate binding region [chemical binding]; other site 743720010330 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 743720010331 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 743720010332 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 743720010333 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 743720010334 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 743720010335 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 743720010336 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 743720010337 catalytic residue [active] 743720010338 putative FPP diphosphate binding site; other site 743720010339 putative FPP binding hydrophobic cleft; other site 743720010340 dimer interface [polypeptide binding]; other site 743720010341 putative IPP diphosphate binding site; other site 743720010342 ribosome recycling factor; Reviewed; Region: frr; PRK00083 743720010343 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 743720010344 hinge region; other site 743720010345 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 743720010346 putative nucleotide binding site [chemical binding]; other site 743720010347 uridine monophosphate binding site [chemical binding]; other site 743720010348 homohexameric interface [polypeptide binding]; other site 743720010349 elongation factor Ts; Provisional; Region: tsf; PRK09377 743720010350 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 743720010351 Elongation factor TS; Region: EF_TS; pfam00889 743720010352 Elongation factor TS; Region: EF_TS; pfam00889 743720010353 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 743720010354 rRNA interaction site [nucleotide binding]; other site 743720010355 S8 interaction site; other site 743720010356 putative laminin-1 binding site; other site 743720010357 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 743720010358 active site 743720010359 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 743720010360 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743720010361 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 743720010362 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 743720010363 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 743720010364 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 743720010365 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 743720010366 Cache domain; Region: Cache_1; pfam02743 743720010367 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720010368 dimerization interface [polypeptide binding]; other site 743720010369 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720010370 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720010371 dimer interface [polypeptide binding]; other site 743720010372 putative CheW interface [polypeptide binding]; other site 743720010373 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 743720010374 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720010375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720010376 homodimer interface [polypeptide binding]; other site 743720010377 catalytic residue [active] 743720010378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720010379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720010380 S-adenosylmethionine binding site [chemical binding]; other site 743720010381 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 743720010382 dimanganese center [ion binding]; other site 743720010383 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 743720010384 dinuclear metal binding motif [ion binding]; other site 743720010385 Domain of unknown function (DUF305); Region: DUF305; cl15795 743720010386 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 743720010387 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 743720010388 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 743720010389 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720010390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720010391 dimer interface [polypeptide binding]; other site 743720010392 phosphorylation site [posttranslational modification] 743720010393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720010394 ATP binding site [chemical binding]; other site 743720010395 Mg2+ binding site [ion binding]; other site 743720010396 G-X-G motif; other site 743720010397 Response regulator receiver domain; Region: Response_reg; pfam00072 743720010398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720010399 active site 743720010400 phosphorylation site [posttranslational modification] 743720010401 intermolecular recognition site; other site 743720010402 dimerization interface [polypeptide binding]; other site 743720010403 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 743720010404 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 743720010405 intersubunit interface [polypeptide binding]; other site 743720010406 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 743720010407 dimer interface [polypeptide binding]; other site 743720010408 substrate binding site [chemical binding]; other site 743720010409 ATP binding site [chemical binding]; other site 743720010410 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 743720010411 thiamine phosphate binding site [chemical binding]; other site 743720010412 active site 743720010413 pyrophosphate binding site [ion binding]; other site 743720010414 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 743720010415 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720010416 inhibitor-cofactor binding pocket; inhibition site 743720010417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720010418 catalytic residue [active] 743720010419 Sel1 repeat; Region: Sel1; cl02723 743720010420 Sel1 repeat; Region: Sel1; cl02723 743720010421 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 743720010422 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 743720010423 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 743720010424 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720010425 FeS/SAM binding site; other site 743720010426 TRAM domain; Region: TRAM; cl01282 743720010427 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 743720010428 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720010429 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 743720010430 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 743720010431 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 743720010432 Transporter associated domain; Region: CorC_HlyC; cl08393 743720010433 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 743720010434 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 743720010435 putative active site [active] 743720010436 catalytic triad [active] 743720010437 putative dimer interface [polypeptide binding]; other site 743720010438 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 743720010439 putative active site [active] 743720010440 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 743720010441 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 743720010442 HIGH motif; other site 743720010443 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 743720010444 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743720010445 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743720010446 active site 743720010447 KMSKS motif; other site 743720010448 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 743720010449 tRNA binding surface [nucleotide binding]; other site 743720010450 Lipopolysaccharide-assembly; Region: LptE; cl01125 743720010451 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 743720010452 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 743720010453 Domain of unknown function; Region: DUF331; cl01149 743720010454 Transglycosylase SLT domain; Region: SLT_2; pfam13406 743720010455 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 743720010456 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720010457 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 743720010458 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 743720010459 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720010460 active site 743720010461 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 743720010462 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 743720010463 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 743720010464 ArsC family; Region: ArsC; pfam03960 743720010465 putative catalytic residues [active] 743720010466 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 743720010467 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 743720010468 putative trimer interface [polypeptide binding]; other site 743720010469 putative CoA binding site [chemical binding]; other site 743720010470 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 743720010471 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 743720010472 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720010473 catalytic residue [active] 743720010474 Fe-S metabolism associated domain; Region: SufE; cl00951 743720010475 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 743720010476 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 743720010477 putative ATP binding site [chemical binding]; other site 743720010478 putative substrate interface [chemical binding]; other site 743720010479 Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191 743720010480 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 743720010481 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 743720010482 Ligand binding site; other site 743720010483 DXD motif; other site 743720010484 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 743720010485 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 743720010486 metal binding site [ion binding]; metal-binding site 743720010487 dimer interface [polypeptide binding]; other site 743720010488 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 743720010489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720010490 S-adenosylmethionine binding site [chemical binding]; other site 743720010491 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 743720010492 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 743720010493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720010494 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 743720010495 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 743720010496 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 743720010497 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 743720010498 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 743720010499 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 743720010500 sensor protein QseC; Provisional; Region: PRK10337 743720010501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720010502 dimer interface [polypeptide binding]; other site 743720010503 phosphorylation site [posttranslational modification] 743720010504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720010505 ATP binding site [chemical binding]; other site 743720010506 Mg2+ binding site [ion binding]; other site 743720010507 G-X-G motif; other site 743720010508 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 743720010509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720010510 active site 743720010511 phosphorylation site [posttranslational modification] 743720010512 intermolecular recognition site; other site 743720010513 dimerization interface [polypeptide binding]; other site 743720010514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720010515 DNA binding site [nucleotide binding] 743720010516 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 743720010517 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 743720010518 Sulfatase; Region: Sulfatase; cl10460 743720010519 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 743720010520 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743720010521 putative active site [active] 743720010522 putative metal binding site [ion binding]; other site 743720010523 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 743720010524 Ligand binding site; other site 743720010525 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 743720010526 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 743720010527 XdhC Rossmann domain; Region: XdhC_C; pfam13478 743720010528 Response regulator receiver domain; Region: Response_reg; pfam00072 743720010529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720010530 active site 743720010531 phosphorylation site [posttranslational modification] 743720010532 intermolecular recognition site; other site 743720010533 dimerization interface [polypeptide binding]; other site 743720010534 Nitrate and nitrite sensing; Region: NIT; pfam08376 743720010535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720010536 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720010537 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720010538 dimer interface [polypeptide binding]; other site 743720010539 putative CheW interface [polypeptide binding]; other site 743720010540 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 743720010541 Membrane transport protein; Region: Mem_trans; cl09117 743720010542 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 743720010543 Citrate transporter; Region: CitMHS; pfam03600 743720010544 Integral membrane protein TerC family; Region: TerC; cl10468 743720010545 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 743720010546 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 743720010547 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 743720010548 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 743720010549 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 743720010550 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 743720010551 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 743720010552 putative active site pocket [active] 743720010553 putative metal binding site [ion binding]; other site 743720010554 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 743720010555 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743720010556 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720010557 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 743720010558 Uncharacterized conserved protein [Function unknown]; Region: COG3391 743720010559 NHL repeat; Region: NHL; pfam01436 743720010560 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720010561 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 743720010562 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 743720010563 DctM-like transporters; Region: DctM; pfam06808 743720010564 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 743720010565 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 743720010566 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 743720010567 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 743720010568 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743720010569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720010570 D-galactonate transporter; Region: 2A0114; TIGR00893 743720010571 putative substrate translocation pore; other site 743720010572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 743720010573 NMT1-like family; Region: NMT1_2; cl15260 743720010574 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720010575 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 743720010576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720010577 Helix-turn-helix domains; Region: HTH; cl00088 743720010578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720010579 dimerization interface [polypeptide binding]; other site 743720010580 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 743720010581 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 743720010582 putative acyl-acceptor binding pocket; other site 743720010583 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 743720010584 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 743720010585 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743720010586 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743720010587 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720010588 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 743720010589 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720010590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720010591 Helix-turn-helix domains; Region: HTH; cl00088 743720010592 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 743720010593 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 743720010594 imidazolonepropionase; Validated; Region: PRK09356 743720010595 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 743720010596 active site 743720010597 Arginase family; Region: Arginase; cl00306 743720010598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 743720010599 Nucleoside recognition; Region: Gate; cl00486 743720010600 urocanate hydratase; Provisional; Region: PRK05414 743720010601 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 743720010602 active sites [active] 743720010603 tetramer interface [polypeptide binding]; other site 743720010604 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 743720010605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720010606 DNA-binding site [nucleotide binding]; DNA binding site 743720010607 UTRA domain; Region: UTRA; cl01230 743720010608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720010609 Helix-turn-helix domains; Region: HTH; cl00088 743720010610 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720010611 dimerization interface [polypeptide binding]; other site 743720010612 EamA-like transporter family; Region: EamA; cl01037 743720010613 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 743720010614 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 743720010615 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 743720010616 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 743720010617 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 743720010618 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 743720010619 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 743720010620 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 743720010621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720010622 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 743720010623 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 743720010624 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 743720010625 tetramer interface [polypeptide binding]; other site 743720010626 active site 743720010627 Mg2+/Mn2+ binding site [ion binding]; other site 743720010628 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 743720010629 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 743720010630 ring oligomerisation interface [polypeptide binding]; other site 743720010631 ATP/Mg binding site [chemical binding]; other site 743720010632 stacking interactions; other site 743720010633 hinge regions; other site 743720010634 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 743720010635 oligomerisation interface [polypeptide binding]; other site 743720010636 mobile loop; other site 743720010637 roof hairpin; other site 743720010638 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 743720010639 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720010640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720010641 NAD(P) binding site [chemical binding]; other site 743720010642 active site 743720010643 Protein of unknown function, DUF481; Region: DUF481; cl01213 743720010644 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 743720010645 active site 743720010646 DNA binding site [nucleotide binding] 743720010647 muropeptide transporter; Validated; Region: ampG; PRK11010 743720010648 muropeptide transporter; Validated; Region: ampG; PRK11010 743720010649 Conserved TM helix; Region: TM_helix; pfam05552 743720010650 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743720010651 Protein of unknown function (DUF520); Region: DUF520; cl00723 743720010652 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 743720010653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720010654 active site 743720010655 phosphorylation site [posttranslational modification] 743720010656 intermolecular recognition site; other site 743720010657 dimerization interface [polypeptide binding]; other site 743720010658 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720010659 metal binding site [ion binding]; metal-binding site 743720010660 active site 743720010661 I-site; other site 743720010662 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 743720010663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720010664 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 743720010665 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720010666 dimerization interface [polypeptide binding]; other site 743720010667 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720010668 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743720010669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720010670 dimer interface [polypeptide binding]; other site 743720010671 phosphorylation site [posttranslational modification] 743720010672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720010673 ATP binding site [chemical binding]; other site 743720010674 Mg2+ binding site [ion binding]; other site 743720010675 G-X-G motif; other site 743720010676 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 743720010677 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 743720010678 PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558 743720010679 probable active site [active] 743720010680 Membrane transport protein; Region: Mem_trans; cl09117 743720010681 hypothetical protein; Provisional; Region: PRK08999 743720010682 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 743720010683 active site 743720010684 8-oxo-dGMP binding site [chemical binding]; other site 743720010685 nudix motif; other site 743720010686 metal binding site [ion binding]; metal-binding site 743720010687 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 743720010688 thiamine phosphate binding site [chemical binding]; other site 743720010689 active site 743720010690 pyrophosphate binding site [ion binding]; other site 743720010691 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 743720010692 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720010693 putative C-terminal domain interface [polypeptide binding]; other site 743720010694 putative GSH binding site (G-site) [chemical binding]; other site 743720010695 putative dimer interface [polypeptide binding]; other site 743720010696 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 743720010697 putative substrate binding pocket (H-site) [chemical binding]; other site 743720010698 putative N-terminal domain interface [polypeptide binding]; other site 743720010699 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 743720010700 heterotetramer interface [polypeptide binding]; other site 743720010701 active site pocket [active] 743720010702 cleavage site 743720010703 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 743720010704 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 743720010705 SEC-C motif; Region: SEC-C; pfam02810 743720010706 Peptidase family M23; Region: Peptidase_M23; pfam01551 743720010707 Protein of unknown function (DUF721); Region: DUF721; cl02324 743720010708 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 743720010709 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 743720010710 cell division protein FtsZ; Validated; Region: PRK09330 743720010711 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 743720010712 nucleotide binding site [chemical binding]; other site 743720010713 SulA interaction site; other site 743720010714 cell division protein FtsA; Region: ftsA; TIGR01174 743720010715 Cell division protein FtsA; Region: FtsA; cl11496 743720010716 Cell division protein FtsA; Region: FtsA; cl11496 743720010717 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 743720010718 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 743720010719 Cell division protein FtsQ; Region: FtsQ; pfam03799 743720010720 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 743720010721 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 743720010722 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720010723 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 743720010724 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743720010725 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743720010726 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743720010727 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 743720010728 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 743720010729 active site 743720010730 homodimer interface [polypeptide binding]; other site 743720010731 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 743720010732 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 743720010733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720010734 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743720010735 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 743720010736 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 743720010737 Mg++ binding site [ion binding]; other site 743720010738 putative catalytic motif [active] 743720010739 putative substrate binding site [chemical binding]; other site 743720010740 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743720010741 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 743720010742 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743720010743 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743720010744 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 743720010745 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743720010746 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743720010747 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743720010748 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 743720010749 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 743720010750 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720010751 Septum formation initiator; Region: DivIC; cl11433 743720010752 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 743720010753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720010754 cell division protein MraZ; Reviewed; Region: PRK00326 743720010755 MraZ protein; Region: MraZ; pfam02381 743720010756 MraZ protein; Region: MraZ; pfam02381 743720010757 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 743720010758 LppC putative lipoprotein; Region: LppC; pfam04348 743720010759 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 743720010760 putative ligand binding site [chemical binding]; other site 743720010761 Restriction endonuclease; Region: Mrr_cat; cl00516 743720010762 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 743720010763 dimer interface [polypeptide binding]; other site 743720010764 active site 743720010765 BON domain; Region: BON; cl02771 743720010766 BON domain; Region: BON; cl02771 743720010767 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 743720010768 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 743720010769 RNase E interface [polypeptide binding]; other site 743720010770 trimer interface [polypeptide binding]; other site 743720010771 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 743720010772 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 743720010773 RNase E interface [polypeptide binding]; other site 743720010774 trimer interface [polypeptide binding]; other site 743720010775 active site 743720010776 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 743720010777 putative nucleic acid binding region [nucleotide binding]; other site 743720010778 G-X-X-G motif; other site 743720010779 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 743720010780 RNA binding site [nucleotide binding]; other site 743720010781 domain interface; other site 743720010782 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 743720010783 16S/18S rRNA binding site [nucleotide binding]; other site 743720010784 S13e-L30e interaction site [polypeptide binding]; other site 743720010785 25S rRNA binding site [nucleotide binding]; other site 743720010786 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 743720010787 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 743720010788 RNA binding site [nucleotide binding]; other site 743720010789 active site 743720010790 Ribosome-binding factor A; Region: RBFA; cl00542 743720010791 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 743720010792 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 743720010793 translation initiation factor IF-2; Region: IF-2; TIGR00487 743720010794 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 743720010795 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 743720010796 G1 box; other site 743720010797 putative GEF interaction site [polypeptide binding]; other site 743720010798 GTP/Mg2+ binding site [chemical binding]; other site 743720010799 Switch I region; other site 743720010800 G2 box; other site 743720010801 G3 box; other site 743720010802 Switch II region; other site 743720010803 G4 box; other site 743720010804 G5 box; other site 743720010805 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 743720010806 Translation-initiation factor 2; Region: IF-2; pfam11987 743720010807 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 743720010808 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 743720010809 NusA N-terminal domain; Region: NusA_N; pfam08529 743720010810 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 743720010811 RNA binding site [nucleotide binding]; other site 743720010812 homodimer interface [polypeptide binding]; other site 743720010813 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 743720010814 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 743720010815 G-X-X-G motif; other site 743720010816 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 743720010817 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 743720010818 ribosome maturation protein RimP; Reviewed; Region: PRK00092 743720010819 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 743720010820 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 743720010821 Sm1 motif; other site 743720010822 D3 - B interaction site; other site 743720010823 D1 - D2 interaction site; other site 743720010824 Hfq - Hfq interaction site; other site 743720010825 RNA binding pocket [nucleotide binding]; other site 743720010826 Sm2 motif; other site 743720010827 Preprotein translocase SecG subunit; Region: SecG; cl09123 743720010828 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 743720010829 substrate binding site [chemical binding]; other site 743720010830 dimer interface [polypeptide binding]; other site 743720010831 catalytic triad [active] 743720010832 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 743720010833 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 743720010834 active site 743720010835 substrate binding site [chemical binding]; other site 743720010836 metal binding site [ion binding]; metal-binding site 743720010837 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 743720010838 dihydropteroate synthase; Region: DHPS; TIGR01496 743720010839 substrate binding pocket [chemical binding]; other site 743720010840 dimer interface [polypeptide binding]; other site 743720010841 inhibitor binding site; inhibition site 743720010842 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 743720010843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720010844 Walker A motif; other site 743720010845 ATP binding site [chemical binding]; other site 743720010846 Walker B motif; other site 743720010847 arginine finger; other site 743720010848 Peptidase family M41; Region: Peptidase_M41; pfam01434 743720010849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 743720010850 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 743720010851 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 743720010852 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 743720010853 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 743720010854 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743720010855 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 743720010856 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720010857 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720010858 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 743720010859 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720010860 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720010861 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 743720010862 IMP binding site; other site 743720010863 dimer interface [polypeptide binding]; other site 743720010864 interdomain contacts; other site 743720010865 partial ornithine binding site; other site 743720010866 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 743720010867 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 743720010868 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 743720010869 catalytic site [active] 743720010870 subunit interface [polypeptide binding]; other site 743720010871 dihydrodipicolinate reductase; Provisional; Region: PRK00048 743720010872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720010873 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 743720010874 chaperone protein DnaJ; Provisional; Region: PRK10767 743720010875 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743720010876 HSP70 interaction site [polypeptide binding]; other site 743720010877 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 743720010878 substrate binding site [polypeptide binding]; other site 743720010879 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 743720010880 Zn binding sites [ion binding]; other site 743720010881 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 743720010882 dimer interface [polypeptide binding]; other site 743720010883 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 743720010884 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 743720010885 heat shock protein GrpE; Provisional; Region: PRK14140 743720010886 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 743720010887 dimer interface [polypeptide binding]; other site 743720010888 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 743720010889 recombination and repair protein; Provisional; Region: PRK10869 743720010890 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 743720010891 Walker A/P-loop; other site 743720010892 ATP binding site [chemical binding]; other site 743720010893 Q-loop/lid; other site 743720010894 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 743720010895 ABC transporter signature motif; other site 743720010896 Walker B; other site 743720010897 D-loop; other site 743720010898 H-loop/switch region; other site 743720010899 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 743720010900 metal binding site 2 [ion binding]; metal-binding site 743720010901 putative DNA binding helix; other site 743720010902 metal binding site 1 [ion binding]; metal-binding site 743720010903 dimer interface [polypeptide binding]; other site 743720010904 structural Zn2+ binding site [ion binding]; other site 743720010905 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 743720010906 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 743720010907 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 743720010908 putative coenzyme Q binding site [chemical binding]; other site 743720010909 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 743720010910 SmpB-tmRNA interface; other site 743720010911 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 743720010912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720010913 DNA-binding site [nucleotide binding]; DNA binding site 743720010914 FCD domain; Region: FCD; cl11656 743720010915 glycolate transporter; Provisional; Region: PRK09695 743720010916 L-lactate permease; Region: Lactate_perm; cl00701 743720010917 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 743720010918 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 743720010919 phosphate binding site [ion binding]; other site 743720010920 D-lactate dehydrogenase; Provisional; Region: PRK11183 743720010921 FAD binding domain; Region: FAD_binding_4; pfam01565 743720010922 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 743720010923 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743720010924 Helix-turn-helix domains; Region: HTH; cl00088 743720010925 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 743720010926 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 743720010927 heme-binding site [chemical binding]; other site 743720010928 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 743720010929 pseudouridine synthase; Region: TIGR00093 743720010930 active site 743720010931 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720010932 Helix-turn-helix domains; Region: HTH; cl00088 743720010933 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 743720010934 putative effector binding pocket; other site 743720010935 putative dimerization interface [polypeptide binding]; other site 743720010936 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 743720010937 homotrimer interaction site [polypeptide binding]; other site 743720010938 putative active site [active] 743720010939 lipoyl synthase; Provisional; Region: PRK05481 743720010940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720010941 FeS/SAM binding site; other site 743720010942 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 743720010943 Protein of unknown function (DUF493); Region: DUF493; cl01102 743720010944 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 743720010945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720010946 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 743720010947 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 743720010948 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 743720010949 Sporulation related domain; Region: SPOR; cl10051 743720010950 Transglycosylase SLT domain; Region: SLT_2; pfam13406 743720010951 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 743720010952 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720010953 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 743720010954 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 743720010955 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 743720010956 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 743720010957 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 743720010958 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 743720010959 Oligomerisation domain; Region: Oligomerisation; cl00519 743720010960 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 743720010961 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 743720010962 active site 743720010963 (T/H)XGH motif; other site 743720010964 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 743720010965 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 743720010966 putative catalytic cysteine [active] 743720010967 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 743720010968 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 743720010969 active site 743720010970 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 743720010971 LrgB-like family; Region: LrgB; cl00596 743720010972 LrgA family; Region: LrgA; cl00608 743720010973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 743720010974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 743720010975 MORN repeat; Region: MORN; cl14787 743720010976 Peptidase C13 family; Region: Peptidase_C13; cl02159 743720010977 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 743720010978 NAD binding site [chemical binding]; other site 743720010979 active site 743720010980 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 743720010981 Citrate transporter; Region: CitMHS; pfam03600 743720010982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720010983 NAD(P) binding site [chemical binding]; other site 743720010984 active site 743720010985 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 743720010986 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 743720010987 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 743720010988 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 743720010989 active site 743720010990 purine riboside binding site [chemical binding]; other site 743720010991 Protein of unknown function (DUF461); Region: DUF461; cl01071 743720010992 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 743720010993 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 743720010994 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 743720010995 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 743720010996 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 743720010997 Helix-turn-helix domains; Region: HTH; cl00088 743720010998 transcriptional activator TtdR; Provisional; Region: PRK09801 743720010999 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720011000 putative effector binding pocket; other site 743720011001 dimerization interface [polypeptide binding]; other site 743720011002 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 743720011003 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 743720011004 putative NAD(P) binding site [chemical binding]; other site 743720011005 dimer interface [polypeptide binding]; other site 743720011006 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 743720011007 iron-sulfur cluster [ion binding]; other site 743720011008 [2Fe-2S] cluster binding site [ion binding]; other site 743720011009 Sugar fermentation stimulation protein; Region: SfsA; cl00647 743720011010 aminotransferase; Validated; Region: PRK07337 743720011011 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720011012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720011013 homodimer interface [polypeptide binding]; other site 743720011014 catalytic residue [active] 743720011015 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 743720011016 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743720011017 active site 743720011018 nucleotide binding site [chemical binding]; other site 743720011019 HIGH motif; other site 743720011020 KMSKS motif; other site 743720011021 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 743720011022 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 743720011023 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 743720011024 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 743720011025 CysD dimerization site [polypeptide binding]; other site 743720011026 G1 box; other site 743720011027 putative GEF interaction site [polypeptide binding]; other site 743720011028 GTP/Mg2+ binding site [chemical binding]; other site 743720011029 Switch I region; other site 743720011030 G2 box; other site 743720011031 G3 box; other site 743720011032 Switch II region; other site 743720011033 G4 box; other site 743720011034 G5 box; other site 743720011035 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 743720011036 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 743720011037 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 743720011038 ligand-binding site [chemical binding]; other site 743720011039 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 743720011040 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 743720011041 Active Sites [active] 743720011042 Uncharacterized conserved protein [Function unknown]; Region: COG0327 743720011043 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 743720011044 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 743720011045 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743720011046 protein binding site [polypeptide binding]; other site 743720011047 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 743720011048 putative transposase OrfB; Reviewed; Region: PHA02517 743720011049 Integrase core domain; Region: rve; cl01316 743720011050 Integrase core domain; Region: rve_3; cl15866 743720011051 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 743720011052 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720011053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720011054 homodimer interface [polypeptide binding]; other site 743720011055 catalytic residue [active] 743720011056 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 743720011057 histidinol dehydrogenase; Region: hisD; TIGR00069 743720011058 NAD binding site [chemical binding]; other site 743720011059 dimerization interface [polypeptide binding]; other site 743720011060 product binding site; other site 743720011061 substrate binding site [chemical binding]; other site 743720011062 zinc binding site [ion binding]; other site 743720011063 catalytic residues [active] 743720011064 ATP phosphoribosyltransferase; Region: HisG; cl15266 743720011065 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 743720011066 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 743720011067 hinge; other site 743720011068 active site 743720011069 BolA-like protein; Region: BolA; cl00386 743720011070 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 743720011071 anti sigma factor interaction site; other site 743720011072 regulatory phosphorylation site [posttranslational modification]; other site 743720011073 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 743720011074 mce related protein; Region: MCE; pfam02470 743720011075 Permease; Region: Permease; cl00510 743720011076 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 743720011077 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 743720011078 Walker A/P-loop; other site 743720011079 ATP binding site [chemical binding]; other site 743720011080 Q-loop/lid; other site 743720011081 ABC transporter signature motif; other site 743720011082 Walker B; other site 743720011083 D-loop; other site 743720011084 H-loop/switch region; other site 743720011085 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 743720011086 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 743720011087 putative active site [active] 743720011088 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 743720011089 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 743720011090 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 743720011091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 743720011092 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 743720011093 OstA-like protein; Region: OstA; cl00844 743720011094 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 743720011095 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 743720011096 Walker A/P-loop; other site 743720011097 ATP binding site [chemical binding]; other site 743720011098 Q-loop/lid; other site 743720011099 ABC transporter signature motif; other site 743720011100 Walker B; other site 743720011101 D-loop; other site 743720011102 H-loop/switch region; other site 743720011103 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 743720011104 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 743720011105 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 743720011106 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 743720011107 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 743720011108 30S subunit binding site; other site 743720011109 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 743720011110 active site 743720011111 phosphorylation site [posttranslational modification] 743720011112 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 743720011113 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 743720011114 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 743720011115 dimerization domain swap beta strand [polypeptide binding]; other site 743720011116 regulatory protein interface [polypeptide binding]; other site 743720011117 active site 743720011118 regulatory phosphorylation site [posttranslational modification]; other site 743720011119 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 743720011120 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 743720011121 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 743720011122 fumarate hydratase; Reviewed; Region: fumC; PRK00485 743720011123 Class II fumarases; Region: Fumarase_classII; cd01362 743720011124 active site 743720011125 tetramer interface [polypeptide binding]; other site 743720011126 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 743720011127 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 743720011128 Protein of unknown function (DUF615); Region: DUF615; cl01147 743720011129 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 743720011130 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 743720011131 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 743720011132 putative active site [active] 743720011133 catalytic triad [active] 743720011134 dimer interface [polypeptide binding]; other site 743720011135 TIGR02099 family protein; Region: TIGR02099 743720011136 AsmA-like C-terminal region; Region: AsmA_2; cl15864 743720011137 ribonuclease G; Provisional; Region: PRK11712 743720011138 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 743720011139 homodimer interface [polypeptide binding]; other site 743720011140 oligonucleotide binding site [chemical binding]; other site 743720011141 Maf-like protein; Region: Maf; pfam02545 743720011142 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 743720011143 active site 743720011144 dimer interface [polypeptide binding]; other site 743720011145 rod shape-determining protein MreD; Region: MreD; cl01087 743720011146 rod shape-determining protein MreC; Provisional; Region: PRK13922 743720011147 rod shape-determining protein MreC; Region: MreC; pfam04085 743720011148 rod shape-determining protein MreB; Provisional; Region: PRK13927 743720011149 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 743720011150 ATP binding site [chemical binding]; other site 743720011151 profilin binding site; other site 743720011152 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 743720011153 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 743720011154 Amidase; Region: Amidase; cl11426 743720011155 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 743720011156 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 743720011157 GatB domain; Region: GatB_Yqey; cl11497 743720011158 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 743720011159 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720011160 Helix-turn-helix domains; Region: HTH; cl00088 743720011161 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720011162 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 743720011163 HPP family; Region: HPP; pfam04982 743720011164 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 743720011165 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 743720011166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 743720011167 Predicted secreted protein [Function unknown]; Region: COG5445 743720011168 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 743720011169 Predicted secreted protein [Function unknown]; Region: COG5445 743720011170 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 743720011171 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 743720011172 MG2 domain; Region: A2M_N; pfam01835 743720011173 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 743720011174 Alpha-2-macroglobulin family; Region: A2M; pfam00207 743720011175 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 743720011176 Protein of unknown function (DUF1175); Region: DUF1175; cl14898 743720011177 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; cl01916 743720011178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 743720011179 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 743720011180 Membrane transport protein; Region: Mem_trans; cl09117 743720011181 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 743720011182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720011183 active site 743720011184 phosphorylation site [posttranslational modification] 743720011185 intermolecular recognition site; other site 743720011186 dimerization interface [polypeptide binding]; other site 743720011187 Helix-turn-helix domains; Region: HTH; cl00088 743720011188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720011189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 743720011190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720011191 D-galactonate transporter; Region: 2A0114; TIGR00893 743720011192 putative substrate translocation pore; other site 743720011193 Protein of unknown function (DUF541); Region: SIMPL; cl01077 743720011194 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 743720011195 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 743720011196 peptide binding site [polypeptide binding]; other site 743720011197 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 743720011198 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 743720011199 peptide binding site [polypeptide binding]; other site 743720011200 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 743720011201 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 743720011202 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 743720011203 active site 743720011204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 743720011205 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 743720011206 Cupin domain; Region: Cupin_2; cl09118 743720011207 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 743720011208 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 743720011209 peptide binding site [polypeptide binding]; other site 743720011210 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 743720011211 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 743720011212 peptide binding site [polypeptide binding]; other site 743720011213 dipeptide transporter permease DppB; Provisional; Region: PRK10914 743720011214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720011215 dimer interface [polypeptide binding]; other site 743720011216 conserved gate region; other site 743720011217 putative PBP binding loops; other site 743720011218 ABC-ATPase subunit interface; other site 743720011219 dipeptide transporter; Provisional; Region: PRK10913 743720011220 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 743720011221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720011222 dimer interface [polypeptide binding]; other site 743720011223 conserved gate region; other site 743720011224 putative PBP binding loops; other site 743720011225 ABC-ATPase subunit interface; other site 743720011226 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 743720011227 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 743720011228 Walker A/P-loop; other site 743720011229 ATP binding site [chemical binding]; other site 743720011230 Q-loop/lid; other site 743720011231 ABC transporter signature motif; other site 743720011232 Walker B; other site 743720011233 D-loop; other site 743720011234 H-loop/switch region; other site 743720011235 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720011236 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 743720011237 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 743720011238 Walker A/P-loop; other site 743720011239 ATP binding site [chemical binding]; other site 743720011240 Q-loop/lid; other site 743720011241 ABC transporter signature motif; other site 743720011242 Walker B; other site 743720011243 D-loop; other site 743720011244 H-loop/switch region; other site 743720011245 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720011246 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 743720011247 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 743720011248 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 743720011249 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 743720011250 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 743720011251 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 743720011252 FAD binding pocket [chemical binding]; other site 743720011253 FAD binding motif [chemical binding]; other site 743720011254 catalytic residues [active] 743720011255 NAD binding pocket [chemical binding]; other site 743720011256 phosphate binding motif [ion binding]; other site 743720011257 beta-alpha-beta structure motif; other site 743720011258 glutamate dehydrogenase; Provisional; Region: PRK09414 743720011259 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 743720011260 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 743720011261 NAD(P) binding site [chemical binding]; other site 743720011262 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 743720011263 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 743720011264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720011265 Walker A motif; other site 743720011266 ATP binding site [chemical binding]; other site 743720011267 Walker B motif; other site 743720011268 arginine finger; other site 743720011269 TROVE domain; Region: TROVE; pfam05731 743720011270 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 743720011271 hypothetical protein; Reviewed; Region: PRK09588 743720011272 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 743720011273 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 743720011274 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in...; Region: RNA_Cyclase_Class_II; cd00874 743720011275 putative active site [active] 743720011276 adenylation catalytic residue [active] 743720011277 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 743720011278 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 743720011279 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 743720011280 ABC transporter; Region: ABC_tran_2; pfam12848 743720011281 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 743720011282 PAS domain; Region: PAS_9; pfam13426 743720011283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720011284 PAS fold; Region: PAS_3; pfam08447 743720011285 putative active site [active] 743720011286 heme pocket [chemical binding]; other site 743720011287 PAS domain S-box; Region: sensory_box; TIGR00229 743720011288 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 743720011289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720011290 PAS domain; Region: PAS_9; pfam13426 743720011291 putative active site [active] 743720011292 heme pocket [chemical binding]; other site 743720011293 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720011294 metal binding site [ion binding]; metal-binding site 743720011295 active site 743720011296 I-site; other site 743720011297 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720011298 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 743720011299 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 743720011300 dimer interface [polypeptide binding]; other site 743720011301 glycine-pyridoxal phosphate binding site [chemical binding]; other site 743720011302 active site 743720011303 folate binding site [chemical binding]; other site 743720011304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720011305 dimer interface [polypeptide binding]; other site 743720011306 phosphorylation site [posttranslational modification] 743720011307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720011308 ATP binding site [chemical binding]; other site 743720011309 Mg2+ binding site [ion binding]; other site 743720011310 G-X-G motif; other site 743720011311 Response regulator receiver domain; Region: Response_reg; pfam00072 743720011312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720011313 active site 743720011314 phosphorylation site [posttranslational modification] 743720011315 intermolecular recognition site; other site 743720011316 dimerization interface [polypeptide binding]; other site 743720011317 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720011318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720011319 active site 743720011320 phosphorylation site [posttranslational modification] 743720011321 intermolecular recognition site; other site 743720011322 dimerization interface [polypeptide binding]; other site 743720011323 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720011324 DNA binding residues [nucleotide binding] 743720011325 probable methyltransferase; Region: TIGR03438 743720011326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720011327 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 743720011328 TIGR03440 family protein; Region: unchr_TIGR03440 743720011329 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 743720011330 Restriction endonuclease; Region: Mrr_cat; cl00516 743720011331 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 743720011332 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 743720011333 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 743720011334 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 743720011335 TM-ABC transporter signature motif; other site 743720011336 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 743720011337 TM-ABC transporter signature motif; other site 743720011338 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 743720011339 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 743720011340 Walker A/P-loop; other site 743720011341 ATP binding site [chemical binding]; other site 743720011342 Q-loop/lid; other site 743720011343 ABC transporter signature motif; other site 743720011344 Walker B; other site 743720011345 D-loop; other site 743720011346 H-loop/switch region; other site 743720011347 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 743720011348 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 743720011349 Walker A/P-loop; other site 743720011350 ATP binding site [chemical binding]; other site 743720011351 Q-loop/lid; other site 743720011352 ABC transporter signature motif; other site 743720011353 Walker B; other site 743720011354 D-loop; other site 743720011355 H-loop/switch region; other site 743720011356 Amidase; Region: Amidase; cl11426 743720011357 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 743720011358 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 743720011359 ligand binding site [chemical binding]; other site 743720011360 regulator interaction site; other site 743720011361 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 743720011362 ANTAR domain; Region: ANTAR; cl04297 743720011363 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 743720011364 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720011365 inhibitor-cofactor binding pocket; inhibition site 743720011366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720011367 catalytic residue [active] 743720011368 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720011369 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 743720011370 tetramerization interface [polypeptide binding]; other site 743720011371 NAD(P) binding site [chemical binding]; other site 743720011372 catalytic residues [active] 743720011373 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720011374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720011375 DNA-binding site [nucleotide binding]; DNA binding site 743720011376 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720011377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720011378 homodimer interface [polypeptide binding]; other site 743720011379 catalytic residue [active] 743720011380 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 743720011381 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 743720011382 PYR/PP interface [polypeptide binding]; other site 743720011383 dimer interface [polypeptide binding]; other site 743720011384 TPP binding site [chemical binding]; other site 743720011385 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743720011386 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 743720011387 TPP-binding site [chemical binding]; other site 743720011388 dimer interface [polypeptide binding]; other site 743720011389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720011390 D-galactonate transporter; Region: 2A0114; TIGR00893 743720011391 putative substrate translocation pore; other site 743720011392 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720011393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720011394 NAD(P) binding site [chemical binding]; other site 743720011395 active site 743720011396 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720011397 Helix-turn-helix domains; Region: HTH; cl00088 743720011398 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 743720011399 dimerization interface [polypeptide binding]; other site 743720011400 substrate binding pocket [chemical binding]; other site 743720011401 Cache domain; Region: Cache_1; pfam02743 743720011402 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720011403 metal binding site [ion binding]; metal-binding site 743720011404 active site 743720011405 I-site; other site 743720011406 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 743720011407 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 743720011408 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720011409 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 743720011410 NAD binding site [chemical binding]; other site 743720011411 homotetramer interface [polypeptide binding]; other site 743720011412 homodimer interface [polypeptide binding]; other site 743720011413 active site 743720011414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720011415 D-galactonate transporter; Region: 2A0114; TIGR00893 743720011416 putative substrate translocation pore; other site 743720011417 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 743720011418 Helix-turn-helix domains; Region: HTH; cl00088 743720011419 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 743720011420 putative dimerization interface [polypeptide binding]; other site 743720011421 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 743720011422 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 743720011423 Dehydratase family; Region: ILVD_EDD; cl00340 743720011424 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 743720011425 DNA topoisomerase III; Provisional; Region: PRK07726 743720011426 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 743720011427 active site 743720011428 putative interdomain interaction site [polypeptide binding]; other site 743720011429 putative metal-binding site [ion binding]; other site 743720011430 putative nucleotide binding site [chemical binding]; other site 743720011431 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 743720011432 domain I; other site 743720011433 DNA binding groove [nucleotide binding] 743720011434 phosphate binding site [ion binding]; other site 743720011435 domain II; other site 743720011436 domain III; other site 743720011437 nucleotide binding site [chemical binding]; other site 743720011438 catalytic site [active] 743720011439 domain IV; other site 743720011440 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 743720011441 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 743720011442 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 743720011443 substrate binding pocket [chemical binding]; other site 743720011444 chain length determination region; other site 743720011445 substrate-Mg2+ binding site; other site 743720011446 catalytic residues [active] 743720011447 aspartate-rich region 1; other site 743720011448 active site lid residues [active] 743720011449 aspartate-rich region 2; other site 743720011450 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 743720011451 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 743720011452 TPP-binding site; other site 743720011453 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 743720011454 PYR/PP interface [polypeptide binding]; other site 743720011455 dimer interface [polypeptide binding]; other site 743720011456 TPP binding site [chemical binding]; other site 743720011457 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743720011458 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720011459 dimer interface [polypeptide binding]; other site 743720011460 putative CheW interface [polypeptide binding]; other site 743720011461 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 743720011462 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 743720011463 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 743720011464 dimerization interface [polypeptide binding]; other site 743720011465 active site 743720011466 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 743720011467 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 743720011468 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 743720011469 G1 box; other site 743720011470 putative GEF interaction site [polypeptide binding]; other site 743720011471 GTP/Mg2+ binding site [chemical binding]; other site 743720011472 Switch I region; other site 743720011473 G2 box; other site 743720011474 G3 box; other site 743720011475 Switch II region; other site 743720011476 G4 box; other site 743720011477 G5 box; other site 743720011478 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 743720011479 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 743720011480 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 743720011481 Trp docking motif [polypeptide binding]; other site 743720011482 putative active site [active] 743720011483 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 743720011484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720011485 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 743720011486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720011487 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743720011488 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 743720011489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720011490 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 743720011491 active site 743720011492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720011493 S-adenosylmethionine binding site [chemical binding]; other site 743720011494 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 743720011495 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720011496 active site 743720011497 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 743720011498 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 743720011499 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 743720011500 Ligand binding site; other site 743720011501 Putative Catalytic site; other site 743720011502 DXD motif; other site 743720011503 TPR repeat; Region: TPR_11; pfam13414 743720011504 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 743720011505 Pilin (bacterial filament); Region: Pilin; pfam00114 743720011506 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 743720011507 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 743720011508 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 743720011509 Walker A motif; other site 743720011510 ATP binding site [chemical binding]; other site 743720011511 Walker B motif; other site 743720011512 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 743720011513 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 743720011514 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 743720011515 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 743720011516 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 743720011517 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 743720011518 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 743720011519 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 743720011520 CoA-binding site [chemical binding]; other site 743720011521 ATP-binding [chemical binding]; other site 743720011522 Domain of unknown function (DUF329); Region: DUF329; cl01144 743720011523 MOSC domain; Region: MOSC; pfam03473 743720011524 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 743720011525 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720011526 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 743720011527 PilZ domain; Region: PilZ; cl01260 743720011528 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 743720011529 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 743720011530 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 743720011531 putative molybdopterin cofactor binding site [chemical binding]; other site 743720011532 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 743720011533 putative molybdopterin cofactor binding site; other site 743720011534 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 743720011535 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743720011536 active site 743720011537 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 743720011538 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 743720011539 active site 743720011540 NAD binding site [chemical binding]; other site 743720011541 metal binding site [ion binding]; metal-binding site 743720011542 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 743720011543 30S subunit binding site; other site 743720011544 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 743720011545 dimer interface [polypeptide binding]; other site 743720011546 FMN binding site [chemical binding]; other site 743720011547 Permease; Region: Permease; cl00510 743720011548 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 743720011549 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720011550 Walker A/P-loop; other site 743720011551 ATP binding site [chemical binding]; other site 743720011552 Q-loop/lid; other site 743720011553 ABC transporter signature motif; other site 743720011554 Walker B; other site 743720011555 D-loop; other site 743720011556 H-loop/switch region; other site 743720011557 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 743720011558 mce related protein; Region: MCE; pfam02470 743720011559 Protein of unknown function (DUF330); Region: DUF330; cl01135 743720011560 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 743720011561 Clp amino terminal domain; Region: Clp_N; pfam02861 743720011562 Clp amino terminal domain; Region: Clp_N; pfam02861 743720011563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720011564 Walker A motif; other site 743720011565 ATP binding site [chemical binding]; other site 743720011566 Walker B motif; other site 743720011567 arginine finger; other site 743720011568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720011569 Walker A motif; other site 743720011570 ATP binding site [chemical binding]; other site 743720011571 Walker B motif; other site 743720011572 arginine finger; other site 743720011573 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 743720011574 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 743720011575 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 743720011576 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 743720011577 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720011578 RNA binding surface [nucleotide binding]; other site 743720011579 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 743720011580 active site 743720011581 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 743720011582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720011583 dimer interface [polypeptide binding]; other site 743720011584 phosphorylation site [posttranslational modification] 743720011585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720011586 ATP binding site [chemical binding]; other site 743720011587 Mg2+ binding site [ion binding]; other site 743720011588 G-X-G motif; other site 743720011589 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720011590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720011591 active site 743720011592 phosphorylation site [posttranslational modification] 743720011593 intermolecular recognition site; other site 743720011594 dimerization interface [polypeptide binding]; other site 743720011595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720011596 Walker A motif; other site 743720011597 ATP binding site [chemical binding]; other site 743720011598 Walker B motif; other site 743720011599 arginine finger; other site 743720011600 Helix-turn-helix domains; Region: HTH; cl00088 743720011601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720011602 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 743720011603 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 743720011604 Type II transport protein GspH; Region: GspH; pfam12019 743720011605 Type II transport protein GspH; Region: GspH; pfam12019 743720011606 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 743720011607 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 743720011608 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 743720011609 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 743720011610 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 743720011611 Tubulin like; Region: Tubulin_2; pfam13809 743720011612 Transcriptional regulators [Transcription]; Region: FadR; COG2186 743720011613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720011614 DNA-binding site [nucleotide binding]; DNA binding site 743720011615 FCD domain; Region: FCD; cl11656 743720011616 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 743720011617 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 743720011618 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 743720011619 Walker A/P-loop; other site 743720011620 ATP binding site [chemical binding]; other site 743720011621 Q-loop/lid; other site 743720011622 ABC transporter signature motif; other site 743720011623 Walker B; other site 743720011624 D-loop; other site 743720011625 H-loop/switch region; other site 743720011626 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 743720011627 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 743720011628 Walker A/P-loop; other site 743720011629 ATP binding site [chemical binding]; other site 743720011630 Q-loop/lid; other site 743720011631 ABC transporter signature motif; other site 743720011632 Walker B; other site 743720011633 D-loop; other site 743720011634 H-loop/switch region; other site 743720011635 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720011636 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 743720011637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720011638 dimer interface [polypeptide binding]; other site 743720011639 conserved gate region; other site 743720011640 ABC-ATPase subunit interface; other site 743720011641 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 743720011642 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 743720011643 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 743720011644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720011645 dimer interface [polypeptide binding]; other site 743720011646 conserved gate region; other site 743720011647 putative PBP binding loops; other site 743720011648 ABC-ATPase subunit interface; other site 743720011649 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 743720011650 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 743720011651 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 743720011652 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 743720011653 putative active site pocket [active] 743720011654 metal binding site [ion binding]; metal-binding site 743720011655 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 743720011656 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 743720011657 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 743720011658 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 743720011659 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720011660 active site 743720011661 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 743720011662 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720011663 metal binding site [ion binding]; metal-binding site 743720011664 active site 743720011665 I-site; other site 743720011666 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 743720011667 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 743720011668 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720011669 active site 743720011670 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 743720011671 SprA-related family; Region: SprA-related; pfam12118 743720011672 AAA domain; Region: AAA_26; pfam13500 743720011673 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720011674 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 743720011675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720011676 S-adenosylmethionine binding site [chemical binding]; other site 743720011677 putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738 743720011678 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 743720011679 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 743720011680 substrate-cofactor binding pocket; other site 743720011681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720011682 catalytic residue [active] 743720011683 biotin synthase; Provisional; Region: PRK15108 743720011684 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720011685 FeS/SAM binding site; other site 743720011686 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 743720011687 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 743720011688 Helix-turn-helix domains; Region: HTH; cl00088 743720011689 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 743720011690 TOBE domain; Region: TOBE_2; cl01440 743720011691 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720011692 Phosphotransferase enzyme family; Region: APH; pfam01636 743720011693 Predicted permeases [General function prediction only]; Region: RarD; COG2962 743720011694 EamA-like transporter family; Region: EamA; cl01037 743720011695 EamA-like transporter family; Region: EamA; cl01037 743720011696 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 743720011697 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 743720011698 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 743720011699 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 743720011700 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720011701 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 743720011702 active site 743720011703 OpgC protein; Region: OpgC_C; cl00792 743720011704 Acyltransferase family; Region: Acyl_transf_3; pfam01757 743720011705 OpgC protein; Region: OpgC_C; cl00792 743720011706 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 743720011707 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 743720011708 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720011709 ligand binding site [chemical binding]; other site 743720011710 flexible hinge region; other site 743720011711 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 743720011712 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743720011713 metal binding triad; other site 743720011714 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 743720011715 active site 743720011716 substrate binding site [chemical binding]; other site 743720011717 catalytic site [active] 743720011718 putative protease; Provisional; Region: PRK15452 743720011719 Peptidase family U32; Region: Peptidase_U32; cl03113 743720011720 Inner membrane protein CreD; Region: CreD; cl01844 743720011721 FOG: CBS domain [General function prediction only]; Region: COG0517 743720011722 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 743720011723 sensory histidine kinase CreC; Provisional; Region: PRK11100 743720011724 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720011725 dimerization interface [polypeptide binding]; other site 743720011726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720011727 dimer interface [polypeptide binding]; other site 743720011728 phosphorylation site [posttranslational modification] 743720011729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720011730 ATP binding site [chemical binding]; other site 743720011731 Mg2+ binding site [ion binding]; other site 743720011732 G-X-G motif; other site 743720011733 DNA-binding response regulator CreB; Provisional; Region: PRK11083 743720011734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720011735 active site 743720011736 phosphorylation site [posttranslational modification] 743720011737 intermolecular recognition site; other site 743720011738 dimerization interface [polypeptide binding]; other site 743720011739 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720011740 DNA binding site [nucleotide binding] 743720011741 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720011742 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720011743 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720011744 dimer interface [polypeptide binding]; other site 743720011745 putative CheW interface [polypeptide binding]; other site 743720011746 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 743720011747 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 743720011748 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 743720011749 Walker A/P-loop; other site 743720011750 ATP binding site [chemical binding]; other site 743720011751 Q-loop/lid; other site 743720011752 ABC transporter signature motif; other site 743720011753 Walker B; other site 743720011754 D-loop; other site 743720011755 H-loop/switch region; other site 743720011756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720011757 dimer interface [polypeptide binding]; other site 743720011758 conserved gate region; other site 743720011759 putative PBP binding loops; other site 743720011760 ABC-ATPase subunit interface; other site 743720011761 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720011762 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720011763 substrate binding pocket [chemical binding]; other site 743720011764 membrane-bound complex binding site; other site 743720011765 hinge residues; other site 743720011766 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 743720011767 putative active site [active] 743720011768 dimerization interface [polypeptide binding]; other site 743720011769 putative tRNAtyr binding site [nucleotide binding]; other site 743720011770 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 743720011771 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720011772 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720011773 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 743720011774 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 743720011775 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 743720011776 fructose-1,6-bisphosphatase family protein; Region: PLN02628 743720011777 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 743720011778 AMP binding site [chemical binding]; other site 743720011779 metal binding site [ion binding]; metal-binding site 743720011780 active site 743720011781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720011782 PAS fold; Region: PAS_4; pfam08448 743720011783 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720011784 metal binding site [ion binding]; metal-binding site 743720011785 active site 743720011786 I-site; other site 743720011787 Flagellin N-methylase; Region: FliB; cl00497 743720011788 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 743720011789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720011790 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 743720011791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720011792 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 743720011793 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 743720011794 Substrate binding site; other site 743720011795 Cupin domain; Region: Cupin_2; cl09118 743720011796 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 743720011797 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720011798 active site 743720011799 PilZ domain; Region: PilZ; cl01260 743720011800 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 743720011801 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 743720011802 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 743720011803 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 743720011804 active site 743720011805 Right handed beta helix region; Region: Beta_helix; pfam13229 743720011806 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 743720011807 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 743720011808 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 743720011809 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 743720011810 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 743720011811 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 743720011812 G1 box; other site 743720011813 putative GEF interaction site [polypeptide binding]; other site 743720011814 GTP/Mg2+ binding site [chemical binding]; other site 743720011815 Switch I region; other site 743720011816 G2 box; other site 743720011817 G3 box; other site 743720011818 Switch II region; other site 743720011819 G4 box; other site 743720011820 G5 box; other site 743720011821 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 743720011822 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 743720011823 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 743720011824 THUMP domain; Region: THUMP; cl12076 743720011825 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 743720011826 Ligand Binding Site [chemical binding]; other site 743720011827 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 743720011828 glutamine synthetase; Provisional; Region: glnA; PRK09469 743720011829 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 743720011830 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720011831 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720011832 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720011833 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743720011834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720011835 dimer interface [polypeptide binding]; other site 743720011836 phosphorylation site [posttranslational modification] 743720011837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720011838 ATP binding site [chemical binding]; other site 743720011839 Mg2+ binding site [ion binding]; other site 743720011840 G-X-G motif; other site 743720011841 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 743720011842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720011843 active site 743720011844 phosphorylation site [posttranslational modification] 743720011845 intermolecular recognition site; other site 743720011846 dimerization interface [polypeptide binding]; other site 743720011847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720011848 Walker A motif; other site 743720011849 ATP binding site [chemical binding]; other site 743720011850 Walker B motif; other site 743720011851 arginine finger; other site 743720011852 Helix-turn-helix domains; Region: HTH; cl00088 743720011853 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 743720011854 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 743720011855 SecA binding site; other site 743720011856 Preprotein binding site; other site 743720011857 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 743720011858 GSH binding site [chemical binding]; other site 743720011859 catalytic residues [active] 743720011860 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 743720011861 active site residue [active] 743720011862 Sulfatase; Region: Sulfatase; cl10460 743720011863 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 743720011864 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 743720011865 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 743720011866 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 743720011867 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 743720011868 protein binding site [polypeptide binding]; other site 743720011869 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 743720011870 Catalytic dyad [active] 743720011871 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 743720011872 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720011873 substrate binding pocket [chemical binding]; other site 743720011874 membrane-bound complex binding site; other site 743720011875 hinge residues; other site 743720011876 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720011877 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720011878 substrate binding pocket [chemical binding]; other site 743720011879 membrane-bound complex binding site; other site 743720011880 hinge residues; other site 743720011881 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 743720011882 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 743720011883 Walker A/P-loop; other site 743720011884 ATP binding site [chemical binding]; other site 743720011885 Q-loop/lid; other site 743720011886 ABC transporter signature motif; other site 743720011887 Walker B; other site 743720011888 D-loop; other site 743720011889 H-loop/switch region; other site 743720011890 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 743720011891 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720011892 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720011893 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 743720011894 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 743720011895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720011896 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 743720011897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 743720011898 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 743720011899 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 743720011900 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 743720011901 substrate binding site [chemical binding]; other site 743720011902 glutamase interaction surface [polypeptide binding]; other site 743720011903 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 743720011904 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 743720011905 catalytic residues [active] 743720011906 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 743720011907 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 743720011908 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 743720011909 putative active site [active] 743720011910 oxyanion strand; other site 743720011911 catalytic triad [active] 743720011912 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 743720011913 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 743720011914 putative active site pocket [active] 743720011915 4-fold oligomerization interface [polypeptide binding]; other site 743720011916 metal binding residues [ion binding]; metal-binding site 743720011917 3-fold/trimer interface [polypeptide binding]; other site 743720011918 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 743720011919 AsmA family; Region: AsmA; pfam05170 743720011920 AsmA-like C-terminal region; Region: AsmA_2; cl15864 743720011921 adenine DNA glycosylase; Provisional; Region: PRK10880 743720011922 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743720011923 minor groove reading motif; other site 743720011924 helix-hairpin-helix signature motif; other site 743720011925 substrate binding pocket [chemical binding]; other site 743720011926 active site 743720011927 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 743720011928 DNA binding and oxoG recognition site [nucleotide binding] 743720011929 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 743720011930 phosphoglycolate phosphatase; Provisional; Region: PRK13223 743720011931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720011932 motif II; other site 743720011933 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 743720011934 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 743720011935 substrate binding site [chemical binding]; other site 743720011936 hexamer interface [polypeptide binding]; other site 743720011937 metal binding site [ion binding]; metal-binding site 743720011938 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 743720011939 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 743720011940 active site 743720011941 NAD binding site [chemical binding]; other site 743720011942 metal binding site [ion binding]; metal-binding site 743720011943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720011944 PAS domain; Region: PAS_9; pfam13426 743720011945 putative active site [active] 743720011946 heme pocket [chemical binding]; other site 743720011947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720011948 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 743720011949 Walker A motif; other site 743720011950 ATP binding site [chemical binding]; other site 743720011951 Walker B motif; other site 743720011952 arginine finger; other site 743720011953 Helix-turn-helix domains; Region: HTH; cl00088 743720011954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720011955 dimer interface [polypeptide binding]; other site 743720011956 conserved gate region; other site 743720011957 putative PBP binding loops; other site 743720011958 ABC-ATPase subunit interface; other site 743720011959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720011960 dimer interface [polypeptide binding]; other site 743720011961 conserved gate region; other site 743720011962 putative PBP binding loops; other site 743720011963 ABC-ATPase subunit interface; other site 743720011964 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 743720011965 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720011966 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 743720011967 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 743720011968 Walker A/P-loop; other site 743720011969 ATP binding site [chemical binding]; other site 743720011970 Q-loop/lid; other site 743720011971 ABC transporter signature motif; other site 743720011972 Walker B; other site 743720011973 D-loop; other site 743720011974 H-loop/switch region; other site 743720011975 TOBE domain; Region: TOBE_2; cl01440 743720011976 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720011977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720011978 active site 743720011979 phosphorylation site [posttranslational modification] 743720011980 intermolecular recognition site; other site 743720011981 dimerization interface [polypeptide binding]; other site 743720011982 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720011983 DNA binding residues [nucleotide binding] 743720011984 dimerization interface [polypeptide binding]; other site 743720011985 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720011986 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720011987 substrate binding pocket [chemical binding]; other site 743720011988 membrane-bound complex binding site; other site 743720011989 hinge residues; other site 743720011990 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720011991 hypothetical protein; Provisional; Region: PRK13560 743720011992 Histidine kinase; Region: HisKA_3; pfam07730 743720011993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720011994 ATP binding site [chemical binding]; other site 743720011995 Mg2+ binding site [ion binding]; other site 743720011996 G-X-G motif; other site 743720011997 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 743720011998 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 743720011999 putative metal binding site [ion binding]; other site 743720012000 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743720012001 HSP70 interaction site [polypeptide binding]; other site 743720012002 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 743720012003 Substrate binding site; other site 743720012004 metal-binding site 743720012005 Phosphotransferase enzyme family; Region: APH; pfam01636 743720012006 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 743720012007 active site 743720012008 ATP binding site [chemical binding]; other site 743720012009 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 743720012010 OstA-like protein; Region: OstA; cl00844 743720012011 Organic solvent tolerance protein; Region: OstA_C; pfam04453 743720012012 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 743720012013 SurA N-terminal domain; Region: SurA_N_3; cl07813 743720012014 PPIC-type PPIASE domain; Region: Rotamase; cl08278 743720012015 PPIC-type PPIASE domain; Region: Rotamase; cl08278 743720012016 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 743720012017 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 743720012018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720012019 Protein of unknown function (DUF525); Region: DUF525; cl01119 743720012020 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 743720012021 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 743720012022 active site 743720012023 metal binding site [ion binding]; metal-binding site 743720012024 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 743720012025 active site residue [active] 743720012026 PrkA family serine protein kinase; Provisional; Region: PRK15455 743720012027 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 743720012028 Uncharacterized conserved protein [Function unknown]; Region: COG2718 743720012029 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 743720012030 SpoVR family protein; Provisional; Region: PRK11767 743720012031 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 743720012032 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 743720012033 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 743720012034 active site 743720012035 NTP binding site [chemical binding]; other site 743720012036 metal binding triad [ion binding]; metal-binding site 743720012037 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 743720012038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 743720012039 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 743720012040 catalytic center binding site [active] 743720012041 ATP binding site [chemical binding]; other site 743720012042 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 743720012043 active site 743720012044 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 743720012045 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 743720012046 UGMP family protein; Validated; Region: PRK09604 743720012047 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 743720012048 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 743720012049 DNA primase, catalytic core; Region: dnaG; TIGR01391 743720012050 CHC2 zinc finger; Region: zf-CHC2; cl15369 743720012051 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 743720012052 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 743720012053 active site 743720012054 metal binding site [ion binding]; metal-binding site 743720012055 interdomain interaction site; other site 743720012056 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 743720012057 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 743720012058 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 743720012059 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 743720012060 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 743720012061 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 743720012062 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720012063 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 743720012064 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720012065 DNA binding residues [nucleotide binding] 743720012066 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 743720012067 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 743720012068 P-loop, Walker A motif; other site 743720012069 Base recognition motif; other site 743720012070 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 743720012071 Protein of unknown function (DUF466); Region: DUF466; cl01082 743720012072 carbon starvation protein A; Provisional; Region: PRK15015 743720012073 Carbon starvation protein CstA; Region: CstA; pfam02554 743720012074 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 743720012075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 743720012076 Cache domain; Region: Cache_2; cl07034 743720012077 Histidine kinase; Region: HisKA_3; pfam07730 743720012078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012079 ATP binding site [chemical binding]; other site 743720012080 Mg2+ binding site [ion binding]; other site 743720012081 G-X-G motif; other site 743720012082 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720012083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012084 active site 743720012085 phosphorylation site [posttranslational modification] 743720012086 intermolecular recognition site; other site 743720012087 dimerization interface [polypeptide binding]; other site 743720012088 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720012089 dimerization interface [polypeptide binding]; other site 743720012090 DNA binding residues [nucleotide binding] 743720012091 PilZ domain; Region: PilZ; cl01260 743720012092 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 743720012093 DNA repair protein RadA; Provisional; Region: PRK11823 743720012094 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 743720012095 Walker A motif/ATP binding site; other site 743720012096 ATP binding site [chemical binding]; other site 743720012097 Walker B motif; other site 743720012098 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 743720012099 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720012100 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720012101 Protein of unknown function (DUF465); Region: DUF465; cl01070 743720012102 Protein of unknown function (DUF465); Region: DUF465; cl01070 743720012103 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 743720012104 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 743720012105 Integral membrane protein TerC family; Region: TerC; cl10468 743720012106 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 743720012107 Transporter associated domain; Region: CorC_HlyC; cl08393 743720012108 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 743720012109 ferredoxin-NADP reductase; Provisional; Region: PRK10926 743720012110 FAD binding pocket [chemical binding]; other site 743720012111 FAD binding motif [chemical binding]; other site 743720012112 phosphate binding motif [ion binding]; other site 743720012113 beta-alpha-beta structure motif; other site 743720012114 NAD binding pocket [chemical binding]; other site 743720012115 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720012116 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 743720012117 dimer interface [polypeptide binding]; other site 743720012118 NADP binding site [chemical binding]; other site 743720012119 catalytic residues [active] 743720012120 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 743720012121 Helix-turn-helix domains; Region: HTH; cl00088 743720012122 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 743720012123 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720012124 dimerization interface [polypeptide binding]; other site 743720012125 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720012126 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 743720012127 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 743720012128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720012129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720012130 S-adenosylmethionine binding site [chemical binding]; other site 743720012131 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 743720012132 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 743720012133 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 743720012134 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720012135 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720012136 substrate binding pocket [chemical binding]; other site 743720012137 membrane-bound complex binding site; other site 743720012138 hinge residues; other site 743720012139 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 743720012140 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 743720012141 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 743720012142 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 743720012143 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743720012144 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720012145 N-terminal plug; other site 743720012146 ligand-binding site [chemical binding]; other site 743720012147 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 743720012148 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 743720012149 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720012150 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 743720012151 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 743720012152 MatE; Region: MatE; cl10513 743720012153 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 743720012154 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 743720012155 homodimer interface [polypeptide binding]; other site 743720012156 NAD binding pocket [chemical binding]; other site 743720012157 ATP binding pocket [chemical binding]; other site 743720012158 Mg binding site [ion binding]; other site 743720012159 active-site loop [active] 743720012160 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 743720012161 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 743720012162 active site 743720012163 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 743720012164 Isochorismatase family; Region: Isochorismatase; pfam00857 743720012165 catalytic triad [active] 743720012166 metal binding site [ion binding]; metal-binding site 743720012167 conserved cis-peptide bond; other site 743720012168 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 743720012169 active site 743720012170 (T/H)XGH motif; other site 743720012171 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 743720012172 nudix motif; other site 743720012173 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 743720012174 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 743720012175 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 743720012176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720012177 Coenzyme A binding pocket [chemical binding]; other site 743720012178 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 743720012179 arginine decarboxylase; Provisional; Region: PRK05354 743720012180 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 743720012181 dimer interface [polypeptide binding]; other site 743720012182 active site 743720012183 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720012184 catalytic residues [active] 743720012185 substrate binding site [chemical binding]; other site 743720012186 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 743720012187 translation initiation factor Sui1; Validated; Region: PRK06824 743720012188 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cd00474 743720012189 Predicted RNA interaction site [nucleotide binding]; other site 743720012190 putative binding site; other site 743720012191 Mutations affecting start-site selection; other site 743720012192 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 743720012193 nudix motif; other site 743720012194 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 743720012195 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 743720012196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 743720012197 active site 743720012198 phosphorylation site [posttranslational modification] 743720012199 intermolecular recognition site; other site 743720012200 dimerization interface [polypeptide binding]; other site 743720012201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012202 active site 743720012203 phosphorylation site [posttranslational modification] 743720012204 intermolecular recognition site; other site 743720012205 dimerization interface [polypeptide binding]; other site 743720012206 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720012207 metal binding site [ion binding]; metal-binding site 743720012208 active site 743720012209 I-site; other site 743720012210 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720012211 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720012212 dimer interface [polypeptide binding]; other site 743720012213 putative CheW interface [polypeptide binding]; other site 743720012214 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 743720012215 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 743720012216 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 743720012217 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 743720012218 DsbD alpha interface [polypeptide binding]; other site 743720012219 catalytic residues [active] 743720012220 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 743720012221 active site 743720012222 trimer interface [polypeptide binding]; other site 743720012223 dimer interface [polypeptide binding]; other site 743720012224 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 743720012225 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743720012226 carboxyltransferase (CT) interaction site; other site 743720012227 biotinylation site [posttranslational modification]; other site 743720012228 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 743720012229 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720012230 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720012231 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 743720012232 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 743720012233 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 743720012234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720012235 S-adenosylmethionine binding site [chemical binding]; other site 743720012236 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 743720012237 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 743720012238 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 743720012239 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 743720012240 FMN binding site [chemical binding]; other site 743720012241 active site 743720012242 catalytic residues [active] 743720012243 substrate binding site [chemical binding]; other site 743720012244 Helix-turn-helix domains; Region: HTH; cl00088 743720012245 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 743720012246 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 743720012247 purine monophosphate binding site [chemical binding]; other site 743720012248 dimer interface [polypeptide binding]; other site 743720012249 putative catalytic residues [active] 743720012250 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 743720012251 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 743720012252 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 743720012253 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 743720012254 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720012255 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 743720012256 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 743720012257 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 743720012258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720012259 dimer interface [polypeptide binding]; other site 743720012260 phosphorylation site [posttranslational modification] 743720012261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012262 ATP binding site [chemical binding]; other site 743720012263 Mg2+ binding site [ion binding]; other site 743720012264 G-X-G motif; other site 743720012265 Response regulator receiver domain; Region: Response_reg; pfam00072 743720012266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012267 active site 743720012268 phosphorylation site [posttranslational modification] 743720012269 intermolecular recognition site; other site 743720012270 dimerization interface [polypeptide binding]; other site 743720012271 Response regulator receiver domain; Region: Response_reg; pfam00072 743720012272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012273 active site 743720012274 phosphorylation site [posttranslational modification] 743720012275 intermolecular recognition site; other site 743720012276 dimerization interface [polypeptide binding]; other site 743720012277 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 743720012278 Helix-turn-helix domains; Region: HTH; cl00088 743720012279 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720012280 dimerization interface [polypeptide binding]; other site 743720012281 ATP/ADP translocase [Energy production and conversion]; Region: COG3202; cl03940 743720012282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720012283 ATP binding site [chemical binding]; other site 743720012284 putative Mg++ binding site [ion binding]; other site 743720012285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720012286 nucleotide binding region [chemical binding]; other site 743720012287 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 743720012288 ATP-binding site [chemical binding]; other site 743720012289 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 743720012290 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 743720012291 active site 743720012292 substrate-binding site [chemical binding]; other site 743720012293 metal-binding site [ion binding] 743720012294 ATP binding site [chemical binding]; other site 743720012295 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 743720012296 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 743720012297 dimerization interface [polypeptide binding]; other site 743720012298 domain crossover interface; other site 743720012299 redox-dependent activation switch; other site 743720012300 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 743720012301 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720012302 RNA binding surface [nucleotide binding]; other site 743720012303 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720012304 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 743720012305 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 743720012306 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720012307 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 743720012308 dimer interface [polypeptide binding]; other site 743720012309 catalytic triad [active] 743720012310 MASE1; Region: MASE1; pfam05231 743720012311 bacterio-opsin activator; Provisional; Region: PRK13558 743720012312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720012313 putative diguanylate cyclase; Provisional; Region: PRK09776 743720012314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720012315 PAS domain; Region: PAS_9; pfam13426 743720012316 putative active site [active] 743720012317 heme pocket [chemical binding]; other site 743720012318 PAS domain S-box; Region: sensory_box; TIGR00229 743720012319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720012320 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720012321 metal binding site [ion binding]; metal-binding site 743720012322 active site 743720012323 I-site; other site 743720012324 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720012325 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 743720012326 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720012327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012328 ATP binding site [chemical binding]; other site 743720012329 Mg2+ binding site [ion binding]; other site 743720012330 G-X-G motif; other site 743720012331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012332 active site 743720012333 phosphorylation site [posttranslational modification] 743720012334 intermolecular recognition site; other site 743720012335 dimerization interface [polypeptide binding]; other site 743720012336 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720012337 DNA binding site [nucleotide binding] 743720012338 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 743720012339 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 743720012340 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 743720012341 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 743720012342 RNA binding site [nucleotide binding]; other site 743720012343 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 743720012344 CoenzymeA binding site [chemical binding]; other site 743720012345 subunit interaction site [polypeptide binding]; other site 743720012346 PHB binding site; other site 743720012347 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 743720012348 Ribosome modulation factor; Region: RMF; cl01207 743720012349 Helix-turn-helix domains; Region: HTH; cl00088 743720012350 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 743720012351 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 743720012352 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720012353 active site 743720012354 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 743720012355 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720012356 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 743720012357 dimer interface [polypeptide binding]; other site 743720012358 active site 743720012359 feruloyl-CoA synthase; Reviewed; Region: PRK08180 743720012360 AMP-binding enzyme; Region: AMP-binding; cl15778 743720012361 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720012362 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 743720012363 NAD(P) binding site [chemical binding]; other site 743720012364 catalytic residues [active] 743720012365 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 743720012366 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720012367 substrate binding site [chemical binding]; other site 743720012368 oxyanion hole (OAH) forming residues; other site 743720012369 trimer interface [polypeptide binding]; other site 743720012370 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 743720012371 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 743720012372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720012373 putative substrate translocation pore; other site 743720012374 outer membrane porin, OprD family; Region: OprD; pfam03573 743720012375 benzoate transport; Region: 2A0115; TIGR00895 743720012376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720012377 putative substrate translocation pore; other site 743720012378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720012379 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 743720012380 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 743720012381 iron-sulfur cluster [ion binding]; other site 743720012382 [2Fe-2S] cluster binding site [ion binding]; other site 743720012383 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 743720012384 alpha subunit interface [polypeptide binding]; other site 743720012385 active site 743720012386 substrate binding site [chemical binding]; other site 743720012387 Fe binding site [ion binding]; other site 743720012388 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 743720012389 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 743720012390 FMN-binding pocket [chemical binding]; other site 743720012391 flavin binding motif; other site 743720012392 phosphate binding motif [ion binding]; other site 743720012393 beta-alpha-beta structure motif; other site 743720012394 NAD binding pocket [chemical binding]; other site 743720012395 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720012396 catalytic loop [active] 743720012397 iron binding site [ion binding]; other site 743720012398 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720012399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720012400 Coenzyme A binding pocket [chemical binding]; other site 743720012401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720012402 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 743720012403 DNA-binding site [nucleotide binding]; DNA binding site 743720012404 FCD domain; Region: FCD; cl11656 743720012405 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 743720012406 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720012407 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 743720012408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720012409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720012410 Protein of unknown function, DUF; Region: DUF411; cl01142 743720012411 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 743720012412 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 743720012413 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 743720012414 NAD binding site [chemical binding]; other site 743720012415 substrate binding site [chemical binding]; other site 743720012416 homodimer interface [polypeptide binding]; other site 743720012417 active site 743720012418 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 743720012419 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 743720012420 substrate binding site; other site 743720012421 tetramer interface; other site 743720012422 Cupin domain; Region: Cupin_2; cl09118 743720012423 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 743720012424 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 743720012425 NADP binding site [chemical binding]; other site 743720012426 active site 743720012427 putative substrate binding site [chemical binding]; other site 743720012428 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 743720012429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720012430 dimer interface [polypeptide binding]; other site 743720012431 phosphorylation site [posttranslational modification] 743720012432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012433 ATP binding site [chemical binding]; other site 743720012434 G-X-G motif; other site 743720012435 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720012436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012437 active site 743720012438 phosphorylation site [posttranslational modification] 743720012439 intermolecular recognition site; other site 743720012440 dimerization interface [polypeptide binding]; other site 743720012441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720012442 Walker A motif; other site 743720012443 ATP binding site [chemical binding]; other site 743720012444 Walker B motif; other site 743720012445 arginine finger; other site 743720012446 Helix-turn-helix domains; Region: HTH; cl00088 743720012447 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720012448 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 743720012449 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 743720012450 DctM-like transporters; Region: DctM; pfam06808 743720012451 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 743720012452 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 743720012453 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 743720012454 active site 743720012455 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 743720012456 active site 743720012457 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 743720012458 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 743720012459 dimer interface [polypeptide binding]; other site 743720012460 ADP-ribose binding site [chemical binding]; other site 743720012461 active site 743720012462 nudix motif; other site 743720012463 metal binding site [ion binding]; metal-binding site 743720012464 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 743720012465 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 743720012466 allophanate hydrolase; Provisional; Region: PRK08186 743720012467 Amidase; Region: Amidase; cl11426 743720012468 urea carboxylase; Region: urea_carbox; TIGR02712 743720012469 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720012470 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720012471 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 743720012472 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 743720012473 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 743720012474 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743720012475 carboxyltransferase (CT) interaction site; other site 743720012476 biotinylation site [posttranslational modification]; other site 743720012477 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720012478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720012479 DNA-binding site [nucleotide binding]; DNA binding site 743720012480 FCD domain; Region: FCD; cl11656 743720012481 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 743720012482 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 743720012483 putative ligand binding site [chemical binding]; other site 743720012484 HEAT repeats; Region: HEAT_2; pfam13646 743720012485 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 743720012486 TM-ABC transporter signature motif; other site 743720012487 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 743720012488 TM-ABC transporter signature motif; other site 743720012489 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 743720012490 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 743720012491 Walker A/P-loop; other site 743720012492 ATP binding site [chemical binding]; other site 743720012493 Q-loop/lid; other site 743720012494 ABC transporter signature motif; other site 743720012495 Walker B; other site 743720012496 D-loop; other site 743720012497 H-loop/switch region; other site 743720012498 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 743720012499 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 743720012500 Walker A/P-loop; other site 743720012501 ATP binding site [chemical binding]; other site 743720012502 Q-loop/lid; other site 743720012503 ABC transporter signature motif; other site 743720012504 Walker B; other site 743720012505 D-loop; other site 743720012506 H-loop/switch region; other site 743720012507 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 743720012508 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 743720012509 putative NAD(P) binding site [chemical binding]; other site 743720012510 homotetramer interface [polypeptide binding]; other site 743720012511 homodimer interface [polypeptide binding]; other site 743720012512 active site 743720012513 Cache domain; Region: Cache_1; pfam02743 743720012514 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720012515 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720012516 dimer interface [polypeptide binding]; other site 743720012517 putative CheW interface [polypeptide binding]; other site 743720012518 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 743720012519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720012520 Coenzyme A binding pocket [chemical binding]; other site 743720012521 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720012522 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720012523 Coenzyme A binding pocket [chemical binding]; other site 743720012524 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 743720012525 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 743720012526 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 743720012527 tetramer interface [polypeptide binding]; other site 743720012528 active site 743720012529 Mg2+/Mn2+ binding site [ion binding]; other site 743720012530 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720012531 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720012532 substrate binding pocket [chemical binding]; other site 743720012533 membrane-bound complex binding site; other site 743720012534 hinge residues; other site 743720012535 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 743720012536 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 743720012537 putative chaperone; Provisional; Region: PRK11678 743720012538 hypothetical protein; Provisional; Region: PRK01254 743720012539 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 743720012540 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 743720012541 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 743720012542 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 743720012543 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720012544 metal binding site [ion binding]; metal-binding site 743720012545 active site 743720012546 I-site; other site 743720012547 replicative DNA helicase; Provisional; Region: PRK05748 743720012548 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 743720012549 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 743720012550 Walker A motif; other site 743720012551 ATP binding site [chemical binding]; other site 743720012552 Walker B motif; other site 743720012553 DNA binding loops [nucleotide binding] 743720012554 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 743720012555 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 743720012556 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 743720012557 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 743720012558 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 743720012559 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 743720012560 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 743720012561 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 743720012562 ribonuclease R; Region: RNase_R; TIGR02063 743720012563 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743720012564 RNB domain; Region: RNB; pfam00773 743720012565 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 743720012566 RNA binding site [nucleotide binding]; other site 743720012567 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720012568 dimer interface [polypeptide binding]; other site 743720012569 putative CheW interface [polypeptide binding]; other site 743720012570 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 743720012571 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 743720012572 GDP-binding site [chemical binding]; other site 743720012573 ACT binding site; other site 743720012574 IMP binding site; other site 743720012575 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 743720012576 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 743720012577 dimer interface [polypeptide binding]; other site 743720012578 motif 1; other site 743720012579 active site 743720012580 motif 2; other site 743720012581 motif 3; other site 743720012582 FtsH protease regulator HflC; Provisional; Region: PRK11029 743720012583 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 743720012584 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 743720012585 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 743720012586 HflK protein; Region: hflK; TIGR01933 743720012587 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 743720012588 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 743720012589 HflX GTPase family; Region: HflX; cd01878 743720012590 G1 box; other site 743720012591 GTP/Mg2+ binding site [chemical binding]; other site 743720012592 Switch I region; other site 743720012593 G2 box; other site 743720012594 G3 box; other site 743720012595 Switch II region; other site 743720012596 G4 box; other site 743720012597 G5 box; other site 743720012598 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 743720012599 Sm1 motif; other site 743720012600 intra - hexamer interaction site; other site 743720012601 inter - hexamer interaction site [polypeptide binding]; other site 743720012602 nucleotide binding pocket [chemical binding]; other site 743720012603 Sm2 motif; other site 743720012604 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720012605 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 743720012606 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 743720012607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012608 ATP binding site [chemical binding]; other site 743720012609 Mg2+ binding site [ion binding]; other site 743720012610 G-X-G motif; other site 743720012611 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 743720012612 ATP binding site [chemical binding]; other site 743720012613 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 743720012614 AMIN domain; Region: AMIN; pfam11741 743720012615 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 743720012616 active site 743720012617 metal binding site [ion binding]; metal-binding site 743720012618 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 743720012619 putative peptidoglycan binding site; other site 743720012620 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 743720012621 putative carbohydrate kinase; Provisional; Region: PRK10565 743720012622 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 743720012623 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 743720012624 putative substrate binding site [chemical binding]; other site 743720012625 putative ATP binding site [chemical binding]; other site 743720012626 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 743720012627 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 743720012628 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 743720012629 putative active site [active] 743720012630 putative substrate binding site [chemical binding]; other site 743720012631 catalytic site [active] 743720012632 dimer interface [polypeptide binding]; other site 743720012633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720012634 GTPase RsgA; Reviewed; Region: PRK12288 743720012635 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743720012636 RNA binding site [nucleotide binding]; other site 743720012637 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 743720012638 GTPase/Zn-binding domain interface [polypeptide binding]; other site 743720012639 GTP/Mg2+ binding site [chemical binding]; other site 743720012640 G4 box; other site 743720012641 G5 box; other site 743720012642 G1 box; other site 743720012643 Switch I region; other site 743720012644 G2 box; other site 743720012645 G3 box; other site 743720012646 Switch II region; other site 743720012647 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 743720012648 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 743720012649 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720012650 ligand binding site [chemical binding]; other site 743720012651 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 743720012652 HDOD domain; Region: HDOD; pfam08668 743720012653 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 743720012654 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 743720012655 active site residue [active] 743720012656 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 743720012657 active site residue [active] 743720012658 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 743720012659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012660 active site 743720012661 phosphorylation site [posttranslational modification] 743720012662 intermolecular recognition site; other site 743720012663 PAS domain S-box; Region: sensory_box; TIGR00229 743720012664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720012665 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720012666 metal binding site [ion binding]; metal-binding site 743720012667 active site 743720012668 I-site; other site 743720012669 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720012670 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 743720012671 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 743720012672 phosphoserine phosphatase SerB; Region: serB; TIGR00338 743720012673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720012674 motif II; other site 743720012675 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 743720012676 TOBE domain; Region: TOBE_2; cl01440 743720012677 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 743720012678 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 743720012679 Walker A/P-loop; other site 743720012680 ATP binding site [chemical binding]; other site 743720012681 Q-loop/lid; other site 743720012682 ABC transporter signature motif; other site 743720012683 Walker B; other site 743720012684 D-loop; other site 743720012685 H-loop/switch region; other site 743720012686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720012687 dimer interface [polypeptide binding]; other site 743720012688 conserved gate region; other site 743720012689 putative PBP binding loops; other site 743720012690 ABC-ATPase subunit interface; other site 743720012691 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 743720012692 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 743720012693 active site 743720012694 dimer interface [polypeptide binding]; other site 743720012695 non-prolyl cis peptide bond; other site 743720012696 insertion regions; other site 743720012697 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 743720012698 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720012699 substrate binding pocket [chemical binding]; other site 743720012700 membrane-bound complex binding site; other site 743720012701 hinge residues; other site 743720012702 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 743720012703 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 743720012704 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 743720012705 dimer interface [polypeptide binding]; other site 743720012706 decamer (pentamer of dimers) interface [polypeptide binding]; other site 743720012707 catalytic triad [active] 743720012708 maltose O-acetyltransferase; Provisional; Region: PRK10092 743720012709 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 743720012710 active site 743720012711 substrate binding site [chemical binding]; other site 743720012712 trimer interface [polypeptide binding]; other site 743720012713 CoA binding site [chemical binding]; other site 743720012714 DNA polymerase II; Reviewed; Region: PRK05762 743720012715 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 743720012716 active site 743720012717 catalytic site [active] 743720012718 substrate binding site [chemical binding]; other site 743720012719 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 743720012720 active site 743720012721 metal-binding site 743720012722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720012723 S-adenosylmethionine binding site [chemical binding]; other site 743720012724 K+ potassium transporter; Region: K_trans; cl15781 743720012725 potassium uptake protein; Region: kup; TIGR00794 743720012726 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 743720012727 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 743720012728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720012729 dimer interface [polypeptide binding]; other site 743720012730 phosphorylation site [posttranslational modification] 743720012731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012732 ATP binding site [chemical binding]; other site 743720012733 Mg2+ binding site [ion binding]; other site 743720012734 G-X-G motif; other site 743720012735 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 743720012736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012737 active site 743720012738 phosphorylation site [posttranslational modification] 743720012739 intermolecular recognition site; other site 743720012740 dimerization interface [polypeptide binding]; other site 743720012741 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720012742 DNA binding site [nucleotide binding] 743720012743 transcriptional regulator BetI; Validated; Region: PRK00767 743720012744 Helix-turn-helix domains; Region: HTH; cl00088 743720012745 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 743720012746 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720012747 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 743720012748 tetrameric interface [polypeptide binding]; other site 743720012749 NAD binding site [chemical binding]; other site 743720012750 catalytic residues [active] 743720012751 choline dehydrogenase; Validated; Region: PRK02106 743720012752 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 743720012753 putative transporter; Provisional; Region: PRK10504 743720012754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720012755 putative substrate translocation pore; other site 743720012756 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 743720012757 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743720012758 ATP binding site [chemical binding]; other site 743720012759 Mg++ binding site [ion binding]; other site 743720012760 motif III; other site 743720012761 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720012762 nucleotide binding region [chemical binding]; other site 743720012763 ATP-binding site [chemical binding]; other site 743720012764 DbpA RNA binding domain; Region: DbpA; pfam03880 743720012765 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720012766 Response regulator receiver domain; Region: Response_reg; pfam00072 743720012767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012768 active site 743720012769 phosphorylation site [posttranslational modification] 743720012770 intermolecular recognition site; other site 743720012771 dimerization interface [polypeptide binding]; other site 743720012772 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720012773 metal binding site [ion binding]; metal-binding site 743720012774 active site 743720012775 I-site; other site 743720012776 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720012777 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720012778 substrate binding pocket [chemical binding]; other site 743720012779 membrane-bound complex binding site; other site 743720012780 hinge residues; other site 743720012781 HI0933-like protein; Region: HI0933_like; pfam03486 743720012782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720012783 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 743720012784 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 743720012785 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 743720012786 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 743720012787 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 743720012788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720012789 Helix-turn-helix domains; Region: HTH; cl00088 743720012790 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 743720012791 putative dimerization interface [polypeptide binding]; other site 743720012792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 743720012793 Protein of unknown function (DUF330); Region: DUF330; cl01135 743720012794 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 743720012795 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 743720012796 CAP-like domain; other site 743720012797 active site 743720012798 primary dimer interface [polypeptide binding]; other site 743720012799 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 743720012800 catalytic motif [active] 743720012801 Catalytic residue [active] 743720012802 SdiA-regulated; Region: SdiA-regulated; cd09971 743720012803 putative active site [active] 743720012804 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 743720012805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012806 ATP binding site [chemical binding]; other site 743720012807 Mg2+ binding site [ion binding]; other site 743720012808 G-X-G motif; other site 743720012809 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 743720012810 anchoring element; other site 743720012811 dimer interface [polypeptide binding]; other site 743720012812 ATP binding site [chemical binding]; other site 743720012813 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 743720012814 active site 743720012815 metal binding site [ion binding]; metal-binding site 743720012816 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 743720012817 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 743720012818 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 743720012819 active site 743720012820 metal binding site [ion binding]; metal-binding site 743720012821 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743720012822 hexamer interface [polypeptide binding]; other site 743720012823 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 743720012824 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 743720012825 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 743720012826 dimer interface [polypeptide binding]; other site 743720012827 ADP-ribose binding site [chemical binding]; other site 743720012828 active site 743720012829 nudix motif; other site 743720012830 metal binding site [ion binding]; metal-binding site 743720012831 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 743720012832 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 743720012833 ThiC-associated domain; Region: ThiC-associated; pfam13667 743720012834 ThiC family; Region: ThiC; cl08031 743720012835 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 743720012836 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 743720012837 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 743720012838 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743720012839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720012840 Helix-turn-helix domains; Region: HTH; cl00088 743720012841 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720012842 dimerization interface [polypeptide binding]; other site 743720012843 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 743720012844 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 743720012845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720012846 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 743720012847 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743720012848 active site 743720012849 catalytic tetrad [active] 743720012850 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 743720012851 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 743720012852 putative ribose interaction site [chemical binding]; other site 743720012853 putative ADP binding site [chemical binding]; other site 743720012854 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743720012855 active site 743720012856 nucleotide binding site [chemical binding]; other site 743720012857 HIGH motif; other site 743720012858 KMSKS motif; other site 743720012859 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 743720012860 Mig-14; Region: Mig-14; pfam07395 743720012861 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 743720012862 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 743720012863 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 743720012864 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 743720012865 Walker A/P-loop; other site 743720012866 ATP binding site [chemical binding]; other site 743720012867 Q-loop/lid; other site 743720012868 ABC transporter signature motif; other site 743720012869 Walker B; other site 743720012870 D-loop; other site 743720012871 H-loop/switch region; other site 743720012872 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720012873 active site 743720012874 substrate binding site [chemical binding]; other site 743720012875 ATP binding site [chemical binding]; other site 743720012876 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 743720012877 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 743720012878 inhibitor-cofactor binding pocket; inhibition site 743720012879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720012880 catalytic residue [active] 743720012881 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 743720012882 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 743720012883 trimer interface [polypeptide binding]; other site 743720012884 active site 743720012885 substrate binding site [chemical binding]; other site 743720012886 CoA binding site [chemical binding]; other site 743720012887 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 743720012888 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720012889 active site 743720012890 OpgC protein; Region: OpgC_C; cl00792 743720012891 Acyltransferase family; Region: Acyl_transf_3; pfam01757 743720012892 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 743720012893 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743720012894 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 743720012895 active site 743720012896 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 743720012897 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 743720012898 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 743720012899 active site 743720012900 ATP binding site [chemical binding]; other site 743720012901 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720012902 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720012903 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720012904 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 743720012905 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 743720012906 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 743720012907 putative active site [active] 743720012908 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 743720012909 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 743720012910 putative active site [active] 743720012911 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 743720012912 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743720012913 metal binding triad; other site 743720012914 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 743720012915 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743720012916 metal binding triad; other site 743720012917 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 743720012918 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 743720012919 dimer interface [polypeptide binding]; other site 743720012920 TPP-binding site [chemical binding]; other site 743720012921 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 743720012922 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743720012923 E3 interaction surface; other site 743720012924 lipoyl attachment site [posttranslational modification]; other site 743720012925 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743720012926 E3 interaction surface; other site 743720012927 lipoyl attachment site [posttranslational modification]; other site 743720012928 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743720012929 E3 interaction surface; other site 743720012930 lipoyl attachment site [posttranslational modification]; other site 743720012931 e3 binding domain; Region: E3_binding; pfam02817 743720012932 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 743720012933 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743720012934 GAF domain; Region: GAF; cl15785 743720012935 RNase II stability modulator; Provisional; Region: PRK10060 743720012936 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720012937 putative active site [active] 743720012938 heme pocket [chemical binding]; other site 743720012939 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720012940 metal binding site [ion binding]; metal-binding site 743720012941 active site 743720012942 I-site; other site 743720012943 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720012944 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 743720012945 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 743720012946 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720012947 Zn2+ binding site [ion binding]; other site 743720012948 Mg2+ binding site [ion binding]; other site 743720012949 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 743720012950 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 743720012951 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 743720012952 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720012953 active site 743720012954 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 743720012955 polyphosphate kinase; Provisional; Region: PRK05443 743720012956 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 743720012957 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 743720012958 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 743720012959 putative active site [active] 743720012960 catalytic site [active] 743720012961 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 743720012962 putative domain interface [polypeptide binding]; other site 743720012963 putative active site [active] 743720012964 catalytic site [active] 743720012965 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 743720012966 dimer interface [polypeptide binding]; other site 743720012967 active site 743720012968 aspartate-rich active site metal binding site; other site 743720012969 allosteric magnesium binding site [ion binding]; other site 743720012970 Schiff base residues; other site 743720012971 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 743720012972 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 743720012973 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 743720012974 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 743720012975 conserved cys residue [active] 743720012976 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 743720012977 LysE type translocator; Region: LysE; cl00565 743720012978 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743720012979 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 743720012980 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720012981 Walker A/P-loop; other site 743720012982 ATP binding site [chemical binding]; other site 743720012983 Q-loop/lid; other site 743720012984 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 743720012985 ABC transporter signature motif; other site 743720012986 Walker B; other site 743720012987 D-loop; other site 743720012988 ABC transporter; Region: ABC_tran_2; pfam12848 743720012989 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 743720012990 Protein of unknown function (DUF2390); Region: DUF2390; cl02376 743720012991 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 743720012992 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 743720012993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720012994 S-adenosylmethionine binding site [chemical binding]; other site 743720012995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 743720012996 SCP-2 sterol transfer family; Region: SCP2; cl01225 743720012997 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720012998 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 743720012999 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 743720013000 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 743720013001 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 743720013002 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 743720013003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 743720013004 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 743720013005 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743720013006 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 743720013007 putative acyl-acceptor binding pocket; other site 743720013008 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720013009 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 743720013010 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 743720013011 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 743720013012 NAD binding site [chemical binding]; other site 743720013013 catalytic Zn binding site [ion binding]; other site 743720013014 structural Zn binding site [ion binding]; other site 743720013015 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 743720013016 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 743720013017 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 743720013018 putative active site [active] 743720013019 putative substrate binding site [chemical binding]; other site 743720013020 putative cosubstrate binding site; other site 743720013021 catalytic site [active] 743720013022 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 743720013023 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 743720013024 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 743720013025 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 743720013026 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 743720013027 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 743720013028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720013029 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 743720013030 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 743720013031 dimer interface [polypeptide binding]; other site 743720013032 glycine-pyridoxal phosphate binding site [chemical binding]; other site 743720013033 active site 743720013034 folate binding site [chemical binding]; other site 743720013035 TraX protein; Region: TraX; cl05434 743720013036 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 743720013037 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 743720013038 tetramer interface [polypeptide binding]; other site 743720013039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720013040 catalytic residue [active] 743720013041 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 743720013042 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 743720013043 FAD binding pocket [chemical binding]; other site 743720013044 FAD binding motif [chemical binding]; other site 743720013045 phosphate binding motif [ion binding]; other site 743720013046 beta-alpha-beta structure motif; other site 743720013047 NAD binding pocket [chemical binding]; other site 743720013048 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720013049 catalytic loop [active] 743720013050 iron binding site [ion binding]; other site 743720013051 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 743720013052 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 743720013053 [2Fe-2S] cluster binding site [ion binding]; other site 743720013054 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 743720013055 putative alpha subunit interface [polypeptide binding]; other site 743720013056 putative active site [active] 743720013057 putative substrate binding site [chemical binding]; other site 743720013058 Fe binding site [ion binding]; other site 743720013059 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743720013060 active site 743720013061 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 743720013062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720013063 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 743720013064 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 743720013065 NMT1-like family; Region: NMT1_2; cl15260 743720013066 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 743720013067 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720013068 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 743720013069 conserved cys residue [active] 743720013070 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 743720013071 active site 743720013072 dimer interface [polypeptide binding]; other site 743720013073 Heme NO binding; Region: HNOB; cl15268 743720013074 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 743720013075 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 743720013076 putative active site [active] 743720013077 putative FMN binding site [chemical binding]; other site 743720013078 putative substrate binding site [chemical binding]; other site 743720013079 putative catalytic residue [active] 743720013080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720013081 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 743720013082 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 743720013083 Cysteine-rich domain; Region: CCG; pfam02754 743720013084 Cysteine-rich domain; Region: CCG; pfam02754 743720013085 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 743720013086 Ligand binding site [chemical binding]; other site 743720013087 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 743720013088 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 743720013089 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 743720013090 Ligand Binding Site [chemical binding]; other site 743720013091 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720013092 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 743720013093 conserved cys residue [active] 743720013094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720013095 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 743720013096 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 743720013097 Walker A/P-loop; other site 743720013098 ATP binding site [chemical binding]; other site 743720013099 Q-loop/lid; other site 743720013100 ABC transporter signature motif; other site 743720013101 Walker B; other site 743720013102 D-loop; other site 743720013103 H-loop/switch region; other site 743720013104 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 743720013105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013106 dimer interface [polypeptide binding]; other site 743720013107 conserved gate region; other site 743720013108 putative PBP binding loops; other site 743720013109 ABC-ATPase subunit interface; other site 743720013110 NMT1-like family; Region: NMT1_2; cl15260 743720013111 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 743720013112 NMT1-like family; Region: NMT1_2; cl15260 743720013113 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 743720013114 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 743720013115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720013116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013117 dimer interface [polypeptide binding]; other site 743720013118 conserved gate region; other site 743720013119 putative PBP binding loops; other site 743720013120 ABC-ATPase subunit interface; other site 743720013121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720013122 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 743720013123 Walker A/P-loop; other site 743720013124 ATP binding site [chemical binding]; other site 743720013125 Q-loop/lid; other site 743720013126 ABC transporter signature motif; other site 743720013127 Walker B; other site 743720013128 D-loop; other site 743720013129 H-loop/switch region; other site 743720013130 TOBE domain; Region: TOBE_2; cl01440 743720013131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720013132 Walker A motif; other site 743720013133 ATP binding site [chemical binding]; other site 743720013134 Walker B motif; other site 743720013135 arginine finger; other site 743720013136 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720013137 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 743720013138 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 743720013139 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720013140 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 743720013141 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 743720013142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013143 dimer interface [polypeptide binding]; other site 743720013144 conserved gate region; other site 743720013145 putative PBP binding loops; other site 743720013146 ABC-ATPase subunit interface; other site 743720013147 sulfate transport protein; Provisional; Region: cysT; CHL00187 743720013148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013149 dimer interface [polypeptide binding]; other site 743720013150 conserved gate region; other site 743720013151 putative PBP binding loops; other site 743720013152 ABC-ATPase subunit interface; other site 743720013153 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 743720013154 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 743720013155 Walker A/P-loop; other site 743720013156 ATP binding site [chemical binding]; other site 743720013157 Q-loop/lid; other site 743720013158 ABC transporter signature motif; other site 743720013159 Walker B; other site 743720013160 D-loop; other site 743720013161 H-loop/switch region; other site 743720013162 TOBE-like domain; Region: TOBE_3; pfam12857 743720013163 Protein of unknown function (DUF962); Region: DUF962; cl01879 743720013164 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 743720013165 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720013166 ligand binding site [chemical binding]; other site 743720013167 flexible hinge region; other site 743720013168 Helix-turn-helix domains; Region: HTH; cl00088 743720013169 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 743720013170 metal binding site [ion binding]; metal-binding site 743720013171 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 743720013172 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 743720013173 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 743720013174 folate binding site [chemical binding]; other site 743720013175 NADP+ binding site [chemical binding]; other site 743720013176 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 743720013177 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 743720013178 putative active site [active] 743720013179 catalytic site [active] 743720013180 putative metal binding site [ion binding]; other site 743720013181 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 743720013182 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720013183 G1 box; other site 743720013184 GTP/Mg2+ binding site [chemical binding]; other site 743720013185 G2 box; other site 743720013186 Switch I region; other site 743720013187 G3 box; other site 743720013188 Switch II region; other site 743720013189 G4 box; other site 743720013190 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 743720013191 Cupin domain; Region: Cupin_2; cl09118 743720013192 EamA-like transporter family; Region: EamA; cl01037 743720013193 EamA-like transporter family; Region: EamA; cl01037 743720013194 transcriptional activator TtdR; Provisional; Region: PRK09801 743720013195 Helix-turn-helix domains; Region: HTH; cl00088 743720013196 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720013197 putative effector binding pocket; other site 743720013198 dimerization interface [polypeptide binding]; other site 743720013199 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 743720013200 dimerization interface [polypeptide binding]; other site 743720013201 active site 743720013202 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 743720013203 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 743720013204 hypothetical protein; Provisional; Region: PRK10039 743720013205 NRDE protein; Region: NRDE; cl01315 743720013206 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 743720013207 GAF domain; Region: GAF; cl15785 743720013208 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 743720013209 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 743720013210 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 743720013211 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 743720013212 putative active site [active] 743720013213 Ap4A binding site [chemical binding]; other site 743720013214 nudix motif; other site 743720013215 putative metal binding site [ion binding]; other site 743720013216 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 743720013217 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 743720013218 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 743720013219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720013220 Histidine kinase; Region: HisKA_3; pfam07730 743720013221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720013222 ATP binding site [chemical binding]; other site 743720013223 Mg2+ binding site [ion binding]; other site 743720013224 G-X-G motif; other site 743720013225 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720013226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720013227 active site 743720013228 phosphorylation site [posttranslational modification] 743720013229 intermolecular recognition site; other site 743720013230 dimerization interface [polypeptide binding]; other site 743720013231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720013232 DNA binding residues [nucleotide binding] 743720013233 dimerization interface [polypeptide binding]; other site 743720013234 CHASE3 domain; Region: CHASE3; cl05000 743720013235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720013236 PAS domain; Region: PAS_9; pfam13426 743720013237 putative active site [active] 743720013238 heme pocket [chemical binding]; other site 743720013239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720013240 dimer interface [polypeptide binding]; other site 743720013241 phosphorylation site [posttranslational modification] 743720013242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720013243 ATP binding site [chemical binding]; other site 743720013244 Mg2+ binding site [ion binding]; other site 743720013245 G-X-G motif; other site 743720013246 Response regulator receiver domain; Region: Response_reg; pfam00072 743720013247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720013248 active site 743720013249 phosphorylation site [posttranslational modification] 743720013250 intermolecular recognition site; other site 743720013251 dimerization interface [polypeptide binding]; other site 743720013252 Response regulator receiver domain; Region: Response_reg; pfam00072 743720013253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720013254 active site 743720013255 phosphorylation site [posttranslational modification] 743720013256 intermolecular recognition site; other site 743720013257 dimerization interface [polypeptide binding]; other site 743720013258 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 743720013259 threonine dehydratase; Reviewed; Region: PRK09224 743720013260 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 743720013261 tetramer interface [polypeptide binding]; other site 743720013262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720013263 catalytic residue [active] 743720013264 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 743720013265 putative Ile/Val binding site [chemical binding]; other site 743720013266 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 743720013267 putative Ile/Val binding site [chemical binding]; other site 743720013268 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 743720013269 tetramer (dimer of dimers) interface [polypeptide binding]; other site 743720013270 active site 743720013271 dimer interface [polypeptide binding]; other site 743720013272 SdiA-regulated; Region: SdiA-regulated; pfam06977 743720013273 SdiA-regulated; Region: SdiA-regulated; cd09971 743720013274 putative active site [active] 743720013275 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 743720013276 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 743720013277 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 743720013278 FAD binding domain; Region: FAD_binding_4; pfam01565 743720013279 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 743720013280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720013281 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 743720013282 L-serine binding site [chemical binding]; other site 743720013283 ACT domain interface; other site 743720013284 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 743720013285 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 743720013286 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 743720013287 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 743720013288 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 743720013289 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743720013290 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 743720013291 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 743720013292 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 743720013293 active site 743720013294 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 743720013295 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 743720013296 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 743720013297 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 743720013298 peptide binding site [polypeptide binding]; other site 743720013299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 743720013300 hypothetical protein; Reviewed; Region: PRK00024 743720013301 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 743720013302 MPN+ (JAMM) motif; other site 743720013303 Zinc-binding site [ion binding]; other site 743720013304 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 743720013305 Flavoprotein; Region: Flavoprotein; cl08021 743720013306 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 743720013307 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 743720013308 trimer interface [polypeptide binding]; other site 743720013309 active site 743720013310 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 743720013311 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 743720013312 active site 743720013313 substrate binding site [chemical binding]; other site 743720013314 metal binding site [ion binding]; metal-binding site 743720013315 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 743720013316 feedback inhibition sensing region; other site 743720013317 homohexameric interface [polypeptide binding]; other site 743720013318 nucleotide binding site [chemical binding]; other site 743720013319 N-acetyl-L-glutamate binding site [chemical binding]; other site 743720013320 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 743720013321 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 743720013322 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 743720013323 DctM-like transporters; Region: DctM; pfam06808 743720013324 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 743720013325 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 743720013326 active site 743720013327 phosphate binding residues; other site 743720013328 catalytic residues [active] 743720013329 Predicted GTPase [General function prediction only]; Region: COG0218 743720013330 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 743720013331 G1 box; other site 743720013332 GTP/Mg2+ binding site [chemical binding]; other site 743720013333 Switch I region; other site 743720013334 G2 box; other site 743720013335 G3 box; other site 743720013336 Switch II region; other site 743720013337 G4 box; other site 743720013338 G5 box; other site 743720013339 DNA polymerase I; Provisional; Region: PRK05755 743720013340 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 743720013341 active site 743720013342 metal binding site 1 [ion binding]; metal-binding site 743720013343 putative 5' ssDNA interaction site; other site 743720013344 metal binding site 3; metal-binding site 743720013345 metal binding site 2 [ion binding]; metal-binding site 743720013346 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 743720013347 putative DNA binding site [nucleotide binding]; other site 743720013348 putative metal binding site [ion binding]; other site 743720013349 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 743720013350 active site 743720013351 catalytic site [active] 743720013352 substrate binding site [chemical binding]; other site 743720013353 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 743720013354 active site 743720013355 DNA binding site [nucleotide binding] 743720013356 catalytic site [active] 743720013357 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 743720013358 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 743720013359 Phosphotransferase enzyme family; Region: APH; pfam01636 743720013360 putative active site [active] 743720013361 putative substrate binding site [chemical binding]; other site 743720013362 ATP binding site [chemical binding]; other site 743720013363 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 743720013364 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 743720013365 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 743720013366 metal binding site [ion binding]; metal-binding site 743720013367 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 743720013368 metal binding site 2 [ion binding]; metal-binding site 743720013369 putative DNA binding helix; other site 743720013370 metal binding site 1 [ion binding]; metal-binding site 743720013371 dimer interface [polypeptide binding]; other site 743720013372 structural Zn2+ binding site [ion binding]; other site 743720013373 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 743720013374 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 743720013375 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720013376 dimer interface [polypeptide binding]; other site 743720013377 putative PBP binding regions; other site 743720013378 ABC-ATPase subunit interface; other site 743720013379 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 743720013380 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 743720013381 Walker A/P-loop; other site 743720013382 ATP binding site [chemical binding]; other site 743720013383 Q-loop/lid; other site 743720013384 ABC transporter signature motif; other site 743720013385 Walker B; other site 743720013386 D-loop; other site 743720013387 H-loop/switch region; other site 743720013388 NIL domain; Region: NIL; cl09633 743720013389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013390 dimer interface [polypeptide binding]; other site 743720013391 conserved gate region; other site 743720013392 ABC-ATPase subunit interface; other site 743720013393 NMT1-like family; Region: NMT1_2; cl15260 743720013394 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 743720013395 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720013396 Helix-turn-helix domains; Region: HTH; cl00088 743720013397 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 743720013398 putative dimerization interface [polypeptide binding]; other site 743720013399 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 743720013400 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720013401 putative metal binding site [ion binding]; other site 743720013402 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 743720013403 Cu(I) binding site [ion binding]; other site 743720013404 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 743720013405 Sulfate transporter family; Region: Sulfate_transp; cl15842 743720013406 Sulfate transporter family; Region: Sulfate_transp; cl15842 743720013407 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 743720013408 active site clefts [active] 743720013409 zinc binding site [ion binding]; other site 743720013410 dimer interface [polypeptide binding]; other site 743720013411 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 743720013412 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 743720013413 active site 743720013414 dimer interface [polypeptide binding]; other site 743720013415 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 743720013416 dimer interface [polypeptide binding]; other site 743720013417 active site 743720013418 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 743720013419 putative substrate binding site [chemical binding]; other site 743720013420 putative ATP binding site [chemical binding]; other site 743720013421 D-xylulose kinases, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 743720013422 N- and C-terminal domain interface [polypeptide binding]; other site 743720013423 D-xylulose kinase; Region: XylB; TIGR01312 743720013424 active site 743720013425 catalytic site [active] 743720013426 metal binding site [ion binding]; metal-binding site 743720013427 xylulose binding site [chemical binding]; other site 743720013428 ATP binding site [chemical binding]; other site 743720013429 putative homodimer interface [polypeptide binding]; other site 743720013430 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 743720013431 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 743720013432 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 743720013433 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 743720013434 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720013435 Walker A/P-loop; other site 743720013436 ATP binding site [chemical binding]; other site 743720013437 Q-loop/lid; other site 743720013438 ABC transporter signature motif; other site 743720013439 Walker B; other site 743720013440 D-loop; other site 743720013441 H-loop/switch region; other site 743720013442 TOBE domain; Region: TOBE_2; cl01440 743720013443 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 743720013444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013445 dimer interface [polypeptide binding]; other site 743720013446 conserved gate region; other site 743720013447 ABC-ATPase subunit interface; other site 743720013448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743720013449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013450 dimer interface [polypeptide binding]; other site 743720013451 conserved gate region; other site 743720013452 putative PBP binding loops; other site 743720013453 ABC-ATPase subunit interface; other site 743720013454 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 743720013455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720013456 Cupin domain; Region: Cupin_2; cl09118 743720013457 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 743720013458 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720013459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720013460 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 743720013461 active site clefts [active] 743720013462 zinc binding site [ion binding]; other site 743720013463 dimer interface [polypeptide binding]; other site 743720013464 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 743720013465 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720013466 FeS/SAM binding site; other site 743720013467 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 743720013468 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 743720013469 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 743720013470 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 743720013471 Cytochrome c; Region: Cytochrom_C; cl11414 743720013472 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743720013473 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720013474 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720013475 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743720013476 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720013477 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743720013478 Activator of aromatic catabolism; Region: XylR_N; pfam06505 743720013479 Heme NO binding; Region: HNOB; cl15268 743720013480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720013481 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 743720013482 Walker A motif; other site 743720013483 ATP binding site [chemical binding]; other site 743720013484 Walker B motif; other site 743720013485 arginine finger; other site 743720013486 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720013487 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 743720013488 NAD(P) binding site [chemical binding]; other site 743720013489 catalytic residues [active] 743720013490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720013491 NAD(P) binding site [chemical binding]; other site 743720013492 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 743720013493 active site 743720013494 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 743720013495 Membrane transport protein; Region: Mem_trans; cl09117 743720013496 Cupin domain; Region: Cupin_2; cl09118 743720013497 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720013498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720013499 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 743720013500 Protein of unknown function; Region: DUF3658; pfam12395 743720013501 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 743720013502 FAD binding domain; Region: FAD_binding_4; pfam01565 743720013503 NMT1-like family; Region: NMT1_2; cl15260 743720013504 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720013505 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 743720013506 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 743720013507 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 743720013508 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 743720013509 active site 743720013510 Zn binding site [ion binding]; other site 743720013511 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 743720013512 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 743720013513 trimer interface [polypeptide binding]; other site 743720013514 putative metal binding site [ion binding]; other site 743720013515 Uncharacterized conserved protein [Function unknown]; Region: COG5642 743720013516 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 743720013517 RES domain; Region: RES; cl02411 743720013518 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 743720013519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720013520 Coenzyme A binding pocket [chemical binding]; other site 743720013521 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 743720013522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720013523 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 743720013524 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 743720013525 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 743720013526 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 743720013527 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 743720013528 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 743720013529 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 743720013530 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 743720013531 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 743720013532 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 743720013533 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 743720013534 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 743720013535 PAAR motif; Region: PAAR_motif; cl15808 743720013536 conserved hypothetical protein; Region: TIGR02270 743720013537 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 743720013538 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 743720013539 active site flap/lid [active] 743720013540 nucleophilic elbow; other site 743720013541 catalytic triad [active] 743720013542 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 743720013543 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 743720013544 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 743720013545 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720013546 AIR carboxylase; Region: AIRC; cl00310 743720013547 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 743720013548 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 743720013549 NAD binding site [chemical binding]; other site 743720013550 substrate binding site [chemical binding]; other site 743720013551 catalytic Zn binding site [ion binding]; other site 743720013552 tetramer interface [polypeptide binding]; other site 743720013553 structural Zn binding site [ion binding]; other site 743720013554 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 743720013555 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720013556 substrate binding pocket [chemical binding]; other site 743720013557 membrane-bound complex binding site; other site 743720013558 hinge residues; other site 743720013559 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720013560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013561 dimer interface [polypeptide binding]; other site 743720013562 conserved gate region; other site 743720013563 putative PBP binding loops; other site 743720013564 ABC-ATPase subunit interface; other site 743720013565 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720013566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013567 dimer interface [polypeptide binding]; other site 743720013568 conserved gate region; other site 743720013569 putative PBP binding loops; other site 743720013570 ABC-ATPase subunit interface; other site 743720013571 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 743720013572 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 743720013573 Walker A/P-loop; other site 743720013574 ATP binding site [chemical binding]; other site 743720013575 Q-loop/lid; other site 743720013576 ABC transporter signature motif; other site 743720013577 Walker B; other site 743720013578 D-loop; other site 743720013579 H-loop/switch region; other site 743720013580 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 743720013581 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 743720013582 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 743720013583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720013584 dimer interface [polypeptide binding]; other site 743720013585 phosphorylation site [posttranslational modification] 743720013586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720013587 Mg2+ binding site [ion binding]; other site 743720013588 G-X-G motif; other site 743720013589 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720013590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720013591 active site 743720013592 phosphorylation site [posttranslational modification] 743720013593 intermolecular recognition site; other site 743720013594 dimerization interface [polypeptide binding]; other site 743720013595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720013596 Walker A motif; other site 743720013597 ATP binding site [chemical binding]; other site 743720013598 Walker B motif; other site 743720013599 arginine finger; other site 743720013600 Helix-turn-helix domains; Region: HTH; cl00088 743720013601 Secretin and TonB N terminus short domain; Region: STN; cl06624 743720013602 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 743720013603 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720013604 N-terminal plug; other site 743720013605 ligand-binding site [chemical binding]; other site 743720013606 fec operon regulator FecR; Reviewed; Region: PRK09774 743720013607 FecR protein; Region: FecR; pfam04773 743720013608 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 743720013609 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720013610 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720013611 DNA binding residues [nucleotide binding] 743720013612 cell density-dependent motility repressor; Provisional; Region: PRK10082 743720013613 Helix-turn-helix domains; Region: HTH; cl00088 743720013614 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720013615 dimerization interface [polypeptide binding]; other site 743720013616 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 743720013617 Aspartase; Region: Aspartase; cd01357 743720013618 active sites [active] 743720013619 tetramer interface [polypeptide binding]; other site 743720013620 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 743720013621 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720013622 substrate binding pocket [chemical binding]; other site 743720013623 membrane-bound complex binding site; other site 743720013624 hinge residues; other site 743720013625 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 743720013626 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720013627 substrate binding pocket [chemical binding]; other site 743720013628 membrane-bound complex binding site; other site 743720013629 hinge residues; other site 743720013630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 743720013631 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 743720013632 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 743720013633 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 743720013634 active site 743720013635 homodimer interface [polypeptide binding]; other site 743720013636 Glutaminase; Region: Glutaminase; cl00907 743720013637 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 743720013638 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 743720013639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720013640 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720013641 substrate binding pocket [chemical binding]; other site 743720013642 membrane-bound complex binding site; other site 743720013643 hinge residues; other site 743720013644 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720013645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013646 dimer interface [polypeptide binding]; other site 743720013647 conserved gate region; other site 743720013648 putative PBP binding loops; other site 743720013649 ABC-ATPase subunit interface; other site 743720013650 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720013651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720013652 Coenzyme A binding pocket [chemical binding]; other site 743720013653 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 743720013654 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 743720013655 putative inner membrane protein; Provisional; Region: PRK11099 743720013656 Sulphur transport; Region: Sulf_transp; cl01018 743720013657 putative inner membrane protein; Provisional; Region: PRK11099 743720013658 pyruvate carboxylase subunit B; Validated; Region: PRK09282 743720013659 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 743720013660 active site 743720013661 catalytic residues [active] 743720013662 metal binding site [ion binding]; metal-binding site 743720013663 homodimer binding site [polypeptide binding]; other site 743720013664 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743720013665 carboxyltransferase (CT) interaction site; other site 743720013666 biotinylation site [posttranslational modification]; other site 743720013667 pyruvate carboxylase subunit A; Validated; Region: PRK07178 743720013668 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720013669 ATP-grasp domain; Region: ATP-grasp_4; cl03087 743720013670 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 743720013671 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720013672 Helix-turn-helix domains; Region: HTH; cl00088 743720013673 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 743720013674 putative dimerization interface [polypeptide binding]; other site 743720013675 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720013676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720013677 DNA-binding site [nucleotide binding]; DNA binding site 743720013678 FCD domain; Region: FCD; cl11656 743720013679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 743720013680 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 743720013681 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 743720013682 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 743720013683 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 743720013684 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 743720013685 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 743720013686 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 743720013687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720013688 PAS fold; Region: PAS_4; pfam08448 743720013689 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720013690 putative active site [active] 743720013691 heme pocket [chemical binding]; other site 743720013692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720013693 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720013694 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720013695 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 743720013696 inhibitor site; inhibition site 743720013697 active site 743720013698 dimer interface [polypeptide binding]; other site 743720013699 catalytic residue [active] 743720013700 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 743720013701 dimer interface [polypeptide binding]; other site 743720013702 NADP binding site [chemical binding]; other site 743720013703 catalytic residues [active] 743720013704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720013705 metabolite-proton symporter; Region: 2A0106; TIGR00883 743720013706 putative substrate translocation pore; other site 743720013707 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 743720013708 Leucine-rich repeats; other site 743720013709 Substrate binding site [chemical binding]; other site 743720013710 Leucine rich repeat; Region: LRR_8; pfam13855 743720013711 Leucine rich repeat; Region: LRR_8; pfam13855 743720013712 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 743720013713 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720013714 active site 743720013715 ATP binding site [chemical binding]; other site 743720013716 substrate binding site [chemical binding]; other site 743720013717 activation loop (A-loop); other site 743720013718 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 743720013719 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 743720013720 metal ion-dependent adhesion site (MIDAS); other site 743720013721 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 743720013722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720013723 Walker A motif; other site 743720013724 ATP binding site [chemical binding]; other site 743720013725 Walker B motif; other site 743720013726 arginine finger; other site 743720013727 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 743720013728 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 743720013729 nudix motif; other site 743720013730 NeuB family; Region: NeuB; cl00496 743720013731 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 743720013732 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 743720013733 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720013734 Walker A/P-loop; other site 743720013735 ATP binding site [chemical binding]; other site 743720013736 Q-loop/lid; other site 743720013737 ABC transporter signature motif; other site 743720013738 Walker B; other site 743720013739 D-loop; other site 743720013740 H-loop/switch region; other site 743720013741 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 743720013742 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 743720013743 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 743720013744 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 743720013745 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 743720013746 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720013747 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 743720013748 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 743720013749 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 743720013750 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 743720013751 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 743720013752 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 743720013753 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720013754 putative active site [active] 743720013755 heme pocket [chemical binding]; other site 743720013756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720013757 PAS fold; Region: PAS_3; pfam08447 743720013758 putative active site [active] 743720013759 heme pocket [chemical binding]; other site 743720013760 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720013761 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743720013762 putative active site [active] 743720013763 heme pocket [chemical binding]; other site 743720013764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720013765 dimer interface [polypeptide binding]; other site 743720013766 phosphorylation site [posttranslational modification] 743720013767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720013768 ATP binding site [chemical binding]; other site 743720013769 Mg2+ binding site [ion binding]; other site 743720013770 G-X-G motif; other site 743720013771 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720013772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720013773 active site 743720013774 phosphorylation site [posttranslational modification] 743720013775 intermolecular recognition site; other site 743720013776 dimerization interface [polypeptide binding]; other site 743720013777 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720013778 DNA binding residues [nucleotide binding] 743720013779 dimerization interface [polypeptide binding]; other site 743720013780 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 743720013781 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 743720013782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720013783 binding surface 743720013784 TPR motif; other site 743720013785 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 743720013786 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 743720013787 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 743720013788 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 743720013789 ATP binding site [chemical binding]; other site 743720013790 Walker A motif; other site 743720013791 hexamer interface [polypeptide binding]; other site 743720013792 Walker B motif; other site 743720013793 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 743720013794 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 743720013795 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 743720013796 SAF domain; Region: SAF; cl00555 743720013797 Flp/Fap pilin component; Region: Flp_Fap; cl01585 743720013798 Response regulator receiver domain; Region: Response_reg; pfam00072 743720013799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720013800 active site 743720013801 phosphorylation site [posttranslational modification] 743720013802 intermolecular recognition site; other site 743720013803 dimerization interface [polypeptide binding]; other site 743720013804 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720013805 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 743720013806 Family description; Region: UvrD_C_2; cl15862 743720013807 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 743720013808 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 743720013809 active site 743720013810 nucleophile elbow; other site 743720013811 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 743720013812 Surface antigen; Region: Bac_surface_Ag; cl03097 743720013813 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 743720013814 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 743720013815 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 743720013816 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 743720013817 putative active site [active] 743720013818 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 743720013819 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 743720013820 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 743720013821 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720013822 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720013823 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720013824 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720013825 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720013826 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720013827 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720013828 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720013829 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720013830 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720013831 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 743720013832 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421 743720013833 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 743720013834 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 743720013835 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 743720013836 Walker A/P-loop; other site 743720013837 ATP binding site [chemical binding]; other site 743720013838 Q-loop/lid; other site 743720013839 ABC transporter signature motif; other site 743720013840 Walker B; other site 743720013841 D-loop; other site 743720013842 H-loop/switch region; other site 743720013843 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 743720013844 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743720013845 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 743720013846 Predicted membrane protein [Function unknown]; Region: COG4655 743720013847 TadE-like protein; Region: TadE; cl10688 743720013848 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 743720013849 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 743720013850 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 743720013851 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 743720013852 active site 743720013853 Predicted membrane protein [Function unknown]; Region: COG2364 743720013854 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 743720013855 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 743720013856 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 743720013857 glutaminase active site [active] 743720013858 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 743720013859 dimer interface [polypeptide binding]; other site 743720013860 active site 743720013861 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 743720013862 dimer interface [polypeptide binding]; other site 743720013863 active site 743720013864 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 743720013865 Helix-turn-helix domains; Region: HTH; cl00088 743720013866 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 743720013867 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 743720013868 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 743720013869 Substrate binding site; other site 743720013870 Mg++ binding site; other site 743720013871 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 743720013872 active site 743720013873 substrate binding site [chemical binding]; other site 743720013874 CoA binding site [chemical binding]; other site 743720013875 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 743720013876 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 743720013877 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 743720013878 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 743720013879 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 743720013880 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 743720013881 alpha subunit interaction interface [polypeptide binding]; other site 743720013882 Walker A motif; other site 743720013883 ATP binding site [chemical binding]; other site 743720013884 Walker B motif; other site 743720013885 inhibitor binding site; inhibition site 743720013886 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 743720013887 ATP synthase; Region: ATP-synt; cl00365 743720013888 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 743720013889 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 743720013890 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 743720013891 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 743720013892 beta subunit interaction interface [polypeptide binding]; other site 743720013893 Walker A motif; other site 743720013894 ATP binding site [chemical binding]; other site 743720013895 Walker B motif; other site 743720013896 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 743720013897 Plant ATP synthase F0; Region: YMF19; cl07975 743720013898 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 743720013899 Plant ATP synthase F0; Region: YMF19; cl07975 743720013900 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 743720013901 ATP synthase subunit C; Region: ATP-synt_C; cl00466 743720013902 ATP synthase A chain; Region: ATP-synt_A; cl00413 743720013903 ATP synthase I chain; Region: ATP_synt_I; cl09170 743720013904 ParB-like partition proteins; Region: parB_part; TIGR00180 743720013905 ParB-like nuclease domain; Region: ParBc; cl02129 743720013906 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 743720013907 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743720013908 P-loop; other site 743720013909 Magnesium ion binding site [ion binding]; other site 743720013910 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743720013911 Magnesium ion binding site [ion binding]; other site 743720013912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 743720013913 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 743720013914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720013915 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 743720013916 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 743720013917 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 743720013918 RHS Repeat; Region: RHS_repeat; cl11982 743720013919 RHS Repeat; Region: RHS_repeat; cl11982 743720013920 RHS Repeat; Region: RHS_repeat; cl11982 743720013921 RHS Repeat; Region: RHS_repeat; cl11982 743720013922 RHS Repeat; Region: RHS_repeat; cl11982 743720013923 RHS Repeat; Region: RHS_repeat; cl11982 743720013924 RHS Repeat; Region: RHS_repeat; cl11982 743720013925 RHS protein; Region: RHS; pfam03527 743720013926 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 743720013927 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 743720013928 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 743720013929 trmE is a tRNA modification GTPase; Region: trmE; cd04164 743720013930 G1 box; other site 743720013931 GTP/Mg2+ binding site [chemical binding]; other site 743720013932 Switch I region; other site 743720013933 G2 box; other site 743720013934 Switch II region; other site 743720013935 G3 box; other site 743720013936 G4 box; other site 743720013937 G5 box; other site 743720013938 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 743720013939 membrane protein insertase; Provisional; Region: PRK01318 743720013940 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 743720013941 Haemolytic domain; Region: Haemolytic; cl00506 743720013942 Ribonuclease P; Region: Ribonuclease_P; cl00457 743720013943 Ribosomal protein L34; Region: Ribosomal_L34; cl00370