-- dump date 20120504_155707 -- class Genbank::misc_feature -- table misc_feature_note -- id note 205918000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 205918000002 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 205918000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918000004 Walker A motif; other site 205918000005 ATP binding site [chemical binding]; other site 205918000006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918000007 Walker B motif; other site 205918000008 arginine finger; other site 205918000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 205918000010 DnaA box-binding interface [nucleotide binding]; other site 205918000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 205918000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 205918000013 putative DNA binding surface [nucleotide binding]; other site 205918000014 dimer interface [polypeptide binding]; other site 205918000015 beta-clamp/clamp loader binding surface; other site 205918000016 beta-clamp/translesion DNA polymerase binding surface; other site 205918000017 recombination protein F; Reviewed; Region: recF; PRK00064 205918000018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918000019 Walker A/P-loop; other site 205918000020 ATP binding site [chemical binding]; other site 205918000021 Q-loop/lid; other site 205918000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918000023 ABC transporter signature motif; other site 205918000024 Walker B; other site 205918000025 D-loop; other site 205918000026 H-loop/switch region; other site 205918000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 205918000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918000029 Mg2+ binding site [ion binding]; other site 205918000030 G-X-G motif; other site 205918000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 205918000032 anchoring element; other site 205918000033 dimer interface [polypeptide binding]; other site 205918000034 ATP binding site [chemical binding]; other site 205918000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 205918000036 active site 205918000037 putative metal-binding site [ion binding]; other site 205918000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 205918000039 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 205918000040 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 205918000041 Predicted amidohydrolase [General function prediction only]; Region: COG0388 205918000042 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 205918000043 putative active site [active] 205918000044 catalytic triad [active] 205918000045 putative dimer interface [polypeptide binding]; other site 205918000046 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 205918000047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918000048 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 205918000049 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 205918000050 putative acyl-acceptor binding pocket; other site 205918000051 1 probable transmembrane helix predicted by TMHMM2.0 205918000052 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 205918000053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918000054 active site 205918000055 motif I; other site 205918000056 motif II; other site 205918000057 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 205918000058 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205918000059 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 205918000060 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 205918000061 dimer interface [polypeptide binding]; other site 205918000062 motif 1; other site 205918000063 active site 205918000064 motif 2; other site 205918000065 motif 3; other site 205918000066 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 205918000067 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 205918000068 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918000069 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 205918000070 putative acyl-acceptor binding pocket; other site 205918000071 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 205918000072 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 205918000073 putative molybdopterin cofactor binding site [chemical binding]; other site 205918000074 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 205918000075 putative molybdopterin cofactor binding site; other site 205918000076 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 205918000077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918000078 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 205918000079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918000080 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 205918000081 16S rRNA methyltransferase B; Provisional; Region: PRK10901 205918000082 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 205918000083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918000084 S-adenosylmethionine binding site [chemical binding]; other site 205918000085 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 205918000086 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 205918000087 putative active site [active] 205918000088 substrate binding site [chemical binding]; other site 205918000089 putative cosubstrate binding site; other site 205918000090 catalytic site [active] 205918000091 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 205918000092 substrate binding site [chemical binding]; other site 205918000093 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 205918000094 active site 205918000095 catalytic residues [active] 205918000096 metal binding site [ion binding]; metal-binding site 205918000097 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918000098 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 205918000099 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 205918000100 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 205918000101 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 205918000102 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 205918000103 NADP binding site [chemical binding]; other site 205918000104 dimer interface [polypeptide binding]; other site 205918000105 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 205918000106 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 205918000107 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 205918000108 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 205918000109 NAD(P) binding site [chemical binding]; other site 205918000110 shikimate binding site; other site 205918000111 Sulfate transporter family; Region: Sulfate_transp; cl15842 205918000112 high affinity sulphate transporter 1; Region: sulP; TIGR00815 205918000113 Sulfate transporter family; Region: Sulfate_transp; cl15842 205918000114 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 205918000115 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000116 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000117 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000118 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000119 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000120 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000121 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000122 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000123 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000124 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000125 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918000126 NMT1-like family; Region: NMT1_2; cl15260 205918000127 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 205918000128 Sulfatase; Region: Sulfatase; cl10460 205918000129 choline-sulfatase; Region: chol_sulfatase; TIGR03417 205918000130 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 205918000131 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 205918000132 Helix-turn-helix domains; Region: HTH; cl00088 205918000133 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 205918000134 dimerization interface [polypeptide binding]; other site 205918000135 substrate binding pocket [chemical binding]; other site 205918000136 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 205918000137 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 205918000138 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 205918000139 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 205918000140 substrate binding site [chemical binding]; other site 205918000141 active site 205918000142 catalytic residues [active] 205918000143 heterodimer interface [polypeptide binding]; other site 205918000144 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 205918000145 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 205918000146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918000147 catalytic residue [active] 205918000148 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918000149 Helix-turn-helix domains; Region: HTH; cl00088 205918000150 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 205918000151 putative dimerization interface [polypeptide binding]; other site 205918000152 putative substrate binding pocket [chemical binding]; other site 205918000153 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 205918000154 1 probable transmembrane helix predicted by TMHMM2.0 205918000155 Dodecin; Region: Dodecin; cl01328 205918000156 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 205918000157 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 205918000158 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 205918000159 OsmC-like protein; Region: OsmC; cl00767 205918000160 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 205918000161 1 probable transmembrane helix predicted by TMHMM2.0 205918000162 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 205918000163 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 205918000164 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 205918000165 trimer interface [polypeptide binding]; other site 205918000166 putative metal binding site [ion binding]; other site 205918000167 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 205918000168 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 205918000169 active site 205918000170 Zn binding site [ion binding]; other site 205918000171 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 205918000172 Cytochrome c; Region: Cytochrom_C; cl11414 205918000173 Iron permease FTR1 family; Region: FTR1; cl00475 205918000174 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000175 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000176 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000177 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000178 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000179 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000180 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000181 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000182 LysE type translocator; Region: LysE; cl00565 205918000183 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000184 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000185 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000186 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000187 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000188 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918000189 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000190 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000191 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000192 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 205918000193 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918000194 Walker A/P-loop; other site 205918000195 ATP binding site [chemical binding]; other site 205918000196 Q-loop/lid; other site 205918000197 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 205918000198 ABC transporter signature motif; other site 205918000199 Walker B; other site 205918000200 D-loop; other site 205918000201 ABC transporter; Region: ABC_tran_2; pfam12848 205918000202 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 205918000203 Protein of unknown function (DUF2390); Region: DUF2390; cl02376 205918000204 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 205918000205 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 205918000206 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 205918000207 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; cl11478 205918000208 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 205918000209 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000210 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000211 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000212 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000213 hemY protein; Region: hemY_coli; TIGR00540 205918000214 HemY protein N-terminus; Region: HemY_N; pfam07219 205918000215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918000216 binding surface 205918000217 TPR motif; other site 205918000218 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000219 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000220 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 205918000221 1 probable transmembrane helix predicted by TMHMM2.0 205918000222 uroporphyrinogen-III synthase; Validated; Region: PRK05752 205918000223 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 205918000224 active site 205918000225 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 205918000226 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 205918000227 domain interfaces; other site 205918000228 active site 205918000229 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 205918000230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918000231 active site 205918000232 phosphorylation site [posttranslational modification] 205918000233 intermolecular recognition site; other site 205918000234 dimerization interface [polypeptide binding]; other site 205918000235 LytTr DNA-binding domain; Region: LytTR; cl04498 205918000236 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 205918000237 Histidine kinase; Region: His_kinase; pfam06580 205918000238 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000239 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000240 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000241 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000242 argininosuccinate lyase; Provisional; Region: PRK00855 205918000243 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 205918000244 active sites [active] 205918000245 tetramer interface [polypeptide binding]; other site 205918000246 Nucleoside recognition; Region: Gate; cl00486 205918000247 Nucleoside recognition; Region: Gate; cl00486 205918000248 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000249 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000250 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000251 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000252 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000253 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000254 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000255 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000256 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918000257 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 205918000258 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000259 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000260 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000261 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000262 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000263 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000264 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 205918000265 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 205918000266 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 205918000267 1 probable transmembrane helix predicted by TMHMM2.0 205918000268 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 205918000269 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 205918000270 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 205918000271 PhoU domain; Region: PhoU; pfam01895 205918000272 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000273 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000274 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000275 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000276 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000277 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000278 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000279 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000280 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 205918000281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918000282 dimerization interface [polypeptide binding]; other site 205918000283 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918000284 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918000285 dimer interface [polypeptide binding]; other site 205918000286 putative CheW interface [polypeptide binding]; other site 205918000287 1 probable transmembrane helix predicted by TMHMM2.0 205918000288 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918000289 Helix-turn-helix domains; Region: HTH; cl00088 205918000290 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918000291 dimerization interface [polypeptide binding]; other site 205918000292 multidrug efflux protein NorA; Provisional; Region: PRK00187 205918000293 MatE; Region: MatE; cl10513 205918000294 MatE; Region: MatE; cl10513 205918000295 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000296 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000297 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000298 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000299 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000300 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000301 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000302 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000303 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000304 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000305 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000306 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000307 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918000308 metal binding site [ion binding]; metal-binding site 205918000309 active site 205918000310 I-site; other site 205918000311 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918000312 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 205918000313 Family description; Region: UvrD_C_2; cl15862 205918000314 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918000315 active site 205918000316 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 205918000317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918000318 Walker A motif; other site 205918000319 ATP binding site [chemical binding]; other site 205918000320 Walker B motif; other site 205918000321 arginine finger; other site 205918000322 Helix-turn-helix domains; Region: HTH; cl00088 205918000323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 205918000324 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 205918000325 1 probable transmembrane helix predicted by TMHMM2.0 205918000326 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 205918000327 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000328 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000329 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000330 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000331 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000332 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000333 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000334 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000335 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 205918000336 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 205918000337 Walker A/P-loop; other site 205918000338 ATP binding site [chemical binding]; other site 205918000339 Q-loop/lid; other site 205918000340 ABC transporter signature motif; other site 205918000341 Walker B; other site 205918000342 D-loop; other site 205918000343 H-loop/switch region; other site 205918000344 TOBE-like domain; Region: TOBE_3; pfam12857 205918000345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000346 dimer interface [polypeptide binding]; other site 205918000347 conserved gate region; other site 205918000348 putative PBP binding loops; other site 205918000349 ABC-ATPase subunit interface; other site 205918000350 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000351 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000352 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000353 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000354 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000355 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000356 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 205918000357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000358 dimer interface [polypeptide binding]; other site 205918000359 conserved gate region; other site 205918000360 putative PBP binding loops; other site 205918000361 ABC-ATPase subunit interface; other site 205918000362 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000363 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000364 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000365 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000366 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000367 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000368 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918000369 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 205918000370 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 205918000371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918000372 PAS domain; Region: PAS_9; pfam13426 205918000373 putative active site [active] 205918000374 heme pocket [chemical binding]; other site 205918000375 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918000376 metal binding site [ion binding]; metal-binding site 205918000377 active site 205918000378 I-site; other site 205918000379 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918000380 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000381 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000382 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 205918000383 Di-iron ligands [ion binding]; other site 205918000384 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 205918000385 Transposase; Region: DDE_Tnp_ISL3; pfam01610 205918000386 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000387 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000388 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918000389 PAS fold; Region: PAS_3; pfam08447 205918000390 putative active site [active] 205918000391 heme pocket [chemical binding]; other site 205918000392 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918000393 metal binding site [ion binding]; metal-binding site 205918000394 active site 205918000395 I-site; other site 205918000396 Response regulator receiver domain; Region: Response_reg; pfam00072 205918000397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918000398 active site 205918000399 phosphorylation site [posttranslational modification] 205918000400 intermolecular recognition site; other site 205918000401 dimerization interface [polypeptide binding]; other site 205918000402 HDOD domain; Region: HDOD; pfam08668 205918000403 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 205918000404 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918000405 inhibitor-cofactor binding pocket; inhibition site 205918000406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918000407 catalytic residue [active] 205918000408 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918000409 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 205918000410 tetramerization interface [polypeptide binding]; other site 205918000411 NAD(P) binding site [chemical binding]; other site 205918000412 catalytic residues [active] 205918000413 LysE type translocator; Region: LysE; cl00565 205918000414 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000415 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000416 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000417 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000418 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000419 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000420 hypothetical protein; Provisional; Region: PRK07588 205918000421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918000422 DDE superfamily endonuclease; Region: DDE_4; cl15789 205918000423 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 205918000424 DDE superfamily endonuclease; Region: DDE_4; cl15789 205918000425 Transposase domain (DUF772); Region: DUF772; pfam05598 205918000426 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 205918000427 DDE superfamily endonuclease; Region: DDE_4; cl15789 205918000428 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 205918000429 Domain of unknown function DUF87; Region: DUF87; pfam01935 205918000430 HerA helicase [Replication, recombination, and repair]; Region: COG0433 205918000431 KTSC domain; Region: KTSC; pfam13619 205918000432 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 205918000433 Protein of unknown function (DUF796); Region: DUF796; cl01226 205918000434 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 205918000435 TIR domain; Region: TIR_2; cl15770 205918000436 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 205918000437 putative transposase OrfB; Reviewed; Region: PHA02517 205918000438 HTH-like domain; Region: HTH_21; pfam13276 205918000439 Integrase core domain; Region: rve; cl01316 205918000440 Integrase core domain; Region: rve_3; cl15866 205918000441 Helix-turn-helix domains; Region: HTH; cl00088 205918000442 polyol permease family; Region: 2A0118; TIGR00897 205918000443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918000444 putative substrate translocation pore; other site 205918000445 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000446 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000447 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000448 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000449 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000450 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000451 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000452 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000453 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000454 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000455 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000456 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000457 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918000458 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000459 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000460 Protein of unknown function DUF262; Region: DUF262; cl14890 205918000461 1 probable transmembrane helix predicted by TMHMM2.0 205918000462 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000463 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000464 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000465 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000466 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000467 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000468 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000469 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000470 LysE type translocator; Region: LysE; cl00565 205918000471 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000472 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000473 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000474 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000475 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000476 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000477 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918000478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918000479 homodimer interface [polypeptide binding]; other site 205918000480 catalytic residue [active] 205918000481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918000482 ISPs1, transposase OrfB 205918000483 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 205918000484 short chain dehydrogenase; Provisional; Region: PRK06924 205918000485 NADP binding site [chemical binding]; other site 205918000486 homodimer interface [polypeptide binding]; other site 205918000487 active site 205918000488 Helix-turn-helix domains; Region: HTH; cl00088 205918000489 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 205918000490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918000491 short chain dehydrogenase; Validated; Region: PRK07069 205918000492 NAD(P) binding site [chemical binding]; other site 205918000493 active site 205918000494 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918000495 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918000496 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918000497 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 205918000498 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000499 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000500 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000501 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 205918000502 Protein of unknown function (DUF805); Region: DUF805; cl01224 205918000503 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000504 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918000505 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 205918000506 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000507 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000508 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000509 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 205918000510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918000511 motif II; other site 205918000512 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918000513 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918000514 putative DNA binding site [nucleotide binding]; other site 205918000515 putative Zn2+ binding site [ion binding]; other site 205918000516 AsnC family; Region: AsnC_trans_reg; pfam01037 205918000517 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205918000518 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 205918000519 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918000520 catalytic residue [active] 205918000521 Gram-negative bacterial tonB protein; Region: TonB; cl10048 205918000522 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 205918000523 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000524 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000525 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000526 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 205918000527 1 probable transmembrane helix predicted by TMHMM2.0 205918000528 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 205918000529 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918000530 N-terminal plug; other site 205918000531 ligand-binding site [chemical binding]; other site 205918000532 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 205918000533 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 205918000534 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 205918000535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000536 dimer interface [polypeptide binding]; other site 205918000537 conserved gate region; other site 205918000538 putative PBP binding loops; other site 205918000539 ABC-ATPase subunit interface; other site 205918000540 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000541 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000542 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000543 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000544 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000545 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000546 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 205918000547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000548 dimer interface [polypeptide binding]; other site 205918000549 conserved gate region; other site 205918000550 putative PBP binding loops; other site 205918000551 ABC-ATPase subunit interface; other site 205918000552 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000553 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000554 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000555 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000556 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000557 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 205918000558 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918000559 Walker A/P-loop; other site 205918000560 ATP binding site [chemical binding]; other site 205918000561 Q-loop/lid; other site 205918000562 ABC transporter signature motif; other site 205918000563 Walker B; other site 205918000564 D-loop; other site 205918000565 H-loop/switch region; other site 205918000566 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918000567 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918000568 Walker A/P-loop; other site 205918000569 ATP binding site [chemical binding]; other site 205918000570 Q-loop/lid; other site 205918000571 ABC transporter signature motif; other site 205918000572 Walker B; other site 205918000573 D-loop; other site 205918000574 H-loop/switch region; other site 205918000575 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918000576 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918000577 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918000578 dimer interface [polypeptide binding]; other site 205918000579 putative CheW interface [polypeptide binding]; other site 205918000580 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000581 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000582 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000583 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000584 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918000585 Helix-turn-helix domains; Region: HTH; cl00088 205918000586 AsnC family; Region: AsnC_trans_reg; pfam01037 205918000587 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 205918000588 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 205918000589 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918000590 inhibitor-cofactor binding pocket; inhibition site 205918000591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918000592 catalytic residue [active] 205918000593 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 205918000594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918000595 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918000596 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 205918000597 tetramerization interface [polypeptide binding]; other site 205918000598 NAD(P) binding site [chemical binding]; other site 205918000599 catalytic residues [active] 205918000600 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 205918000601 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 205918000602 metal binding site [ion binding]; metal-binding site 205918000603 putative dimer interface [polypeptide binding]; other site 205918000604 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918000605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918000606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 205918000607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918000608 putative oxidoreductase; Provisional; Region: PRK08275 205918000609 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 205918000610 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 205918000611 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 205918000612 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918000613 Walker A/P-loop; other site 205918000614 ATP binding site [chemical binding]; other site 205918000615 Q-loop/lid; other site 205918000616 ABC transporter signature motif; other site 205918000617 Walker B; other site 205918000618 D-loop; other site 205918000619 H-loop/switch region; other site 205918000620 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918000621 Walker A/P-loop; other site 205918000622 ATP binding site [chemical binding]; other site 205918000623 Q-loop/lid; other site 205918000624 ABC transporter signature motif; other site 205918000625 Walker B; other site 205918000626 D-loop; other site 205918000627 H-loop/switch region; other site 205918000628 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918000629 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 205918000630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000631 dimer interface [polypeptide binding]; other site 205918000632 conserved gate region; other site 205918000633 ABC-ATPase subunit interface; other site 205918000634 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000635 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000636 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000637 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000638 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205918000639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000640 dimer interface [polypeptide binding]; other site 205918000641 conserved gate region; other site 205918000642 putative PBP binding loops; other site 205918000643 ABC-ATPase subunit interface; other site 205918000644 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000645 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000646 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000647 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000648 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000649 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918000650 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 205918000651 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205918000652 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918000653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918000654 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 205918000655 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918000656 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205918000657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918000658 Coenzyme A binding pocket [chemical binding]; other site 205918000659 Cupin domain; Region: Cupin_2; cl09118 205918000660 1 probable transmembrane helix predicted by TMHMM2.0 205918000661 1 probable transmembrane helix predicted by TMHMM2.0 205918000662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918000663 Coenzyme A binding pocket [chemical binding]; other site 205918000664 N-acetylglutamate synthase; Validated; Region: PRK05279 205918000665 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 205918000666 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 205918000667 active site 205918000668 substrate-binding site [chemical binding]; other site 205918000669 metal-binding site [ion binding] 205918000670 ATP binding site [chemical binding]; other site 205918000671 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 205918000672 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 205918000673 dimerization interface [polypeptide binding]; other site 205918000674 domain crossover interface; other site 205918000675 redox-dependent activation switch; other site 205918000676 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205918000677 RNA binding surface [nucleotide binding]; other site 205918000678 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918000679 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 205918000680 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 205918000681 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918000682 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 205918000683 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 205918000684 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000685 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000686 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000687 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000688 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000689 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000690 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000691 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918000692 Phosphate-starvation-inducible E; Region: PsiE; cl01264 205918000693 adenylate cyclase; Provisional; Region: cyaA; PRK09450 205918000694 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 205918000695 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 205918000696 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 205918000697 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 205918000698 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 205918000699 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cl00238 205918000700 putative iron binding site [ion binding]; other site 205918000701 1 probable transmembrane helix predicted by TMHMM2.0 205918000702 diaminopimelate decarboxylase; Region: lysA; TIGR01048 205918000703 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 205918000704 active site 205918000705 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918000706 substrate binding site [chemical binding]; other site 205918000707 catalytic residues [active] 205918000708 dimer interface [polypeptide binding]; other site 205918000709 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 205918000710 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 205918000711 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 205918000712 GAF domain; Region: GAF; cl15785 205918000713 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205918000714 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 205918000715 active site 205918000716 Int/Topo IB signature motif; other site 205918000717 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 205918000718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918000719 motif II; other site 205918000720 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 205918000721 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 205918000722 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000723 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000724 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000725 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000726 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000727 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000728 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000729 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000730 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000731 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000732 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000733 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000734 Nitrogen regulatory protein P-II; Region: P-II; cl00412 205918000735 Nitrogen regulatory protein P-II; Region: P-II; smart00938 205918000736 Membrane fusogenic activity; Region: BMFP; cl01115 205918000737 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 205918000738 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 205918000739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918000740 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 205918000741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918000742 NAD(P) binding site [chemical binding]; other site 205918000743 active site 205918000744 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000745 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000746 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000747 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000748 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000749 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000750 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000751 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000752 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 205918000753 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 205918000754 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918000755 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 205918000756 Citrate transporter; Region: CitMHS; pfam03600 205918000757 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 205918000758 transmembrane helices; other site 205918000759 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000760 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000761 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000762 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000763 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000764 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000765 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000766 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000767 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000768 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000769 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000770 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000771 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 205918000772 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 205918000773 putative deacylase active site [active] 205918000774 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 205918000775 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 205918000776 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 205918000777 generic binding surface II; other site 205918000778 ssDNA binding site; other site 205918000779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918000780 ATP binding site [chemical binding]; other site 205918000781 putative Mg++ binding site [ion binding]; other site 205918000782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918000783 nucleotide binding region [chemical binding]; other site 205918000784 ATP-binding site [chemical binding]; other site 205918000785 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 205918000786 Helix-turn-helix domains; Region: HTH; cl00088 205918000787 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 205918000788 dimerization interface [polypeptide binding]; other site 205918000789 Gram-negative bacterial tonB protein; Region: TonB; cl10048 205918000790 1 probable transmembrane helix predicted by TMHMM2.0 205918000791 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 205918000792 1 probable transmembrane helix predicted by TMHMM2.0 205918000793 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 205918000794 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000795 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000796 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000797 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918000798 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205918000799 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 205918000800 putative NAD(P) binding site [chemical binding]; other site 205918000801 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 205918000802 homotrimer interaction site [polypeptide binding]; other site 205918000803 putative active site [active] 205918000804 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 205918000805 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205918000806 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 205918000807 synthetase active site [active] 205918000808 NTP binding site [chemical binding]; other site 205918000809 metal binding site [ion binding]; metal-binding site 205918000810 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 205918000811 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 205918000812 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 205918000813 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 205918000814 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 205918000815 catalytic site [active] 205918000816 G-X2-G-X-G-K; other site 205918000817 hypothetical protein; Provisional; Region: PRK11820 205918000818 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 205918000819 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 205918000820 ribonuclease PH; Reviewed; Region: rph; PRK00173 205918000821 Ribonuclease PH; Region: RNase_PH_bact; cd11362 205918000822 hexamer interface [polypeptide binding]; other site 205918000823 active site 205918000824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296; cl15800 205918000825 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000826 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000827 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918000828 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 205918000829 putative active site [active] 205918000830 putative catalytic site [active] 205918000831 putative DNA binding site [nucleotide binding]; other site 205918000832 putative phosphate binding site [ion binding]; other site 205918000833 metal binding site A [ion binding]; metal-binding site 205918000834 putative AP binding site [nucleotide binding]; other site 205918000835 putative metal binding site B [ion binding]; other site 205918000836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918000837 active site 205918000838 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 205918000839 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 205918000840 feedback inhibition sensing region; other site 205918000841 homohexameric interface [polypeptide binding]; other site 205918000842 nucleotide binding site [chemical binding]; other site 205918000843 N-acetyl-L-glutamate binding site [chemical binding]; other site 205918000844 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 205918000845 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 205918000846 active site 205918000847 substrate binding site [chemical binding]; other site 205918000848 metal binding site [ion binding]; metal-binding site 205918000849 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 205918000850 trimer interface [polypeptide binding]; other site 205918000851 active site 205918000852 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 205918000853 Flavoprotein; Region: Flavoprotein; cl08021 205918000854 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 205918000855 hypothetical protein; Reviewed; Region: PRK00024 205918000856 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 205918000857 MPN+ (JAMM) motif; other site 205918000858 Zinc-binding site [ion binding]; other site 205918000859 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 205918000860 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205918000861 peptide binding site [polypeptide binding]; other site 205918000862 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 205918000863 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 205918000864 Cupin domain; Region: Cupin_2; cl09118 205918000865 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 205918000866 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 205918000867 NAD(P) binding site [chemical binding]; other site 205918000868 catalytic residues [active] 205918000869 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918000870 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000871 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000872 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000873 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000874 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000875 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000876 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000877 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000878 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000879 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000880 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000881 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000882 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 205918000883 PLD-like domain; Region: PLDc_2; pfam13091 205918000884 putative active site [active] 205918000885 catalytic site [active] 205918000886 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 205918000887 putative active site [active] 205918000888 catalytic site [active] 205918000889 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 205918000890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918000891 DNA-binding site [nucleotide binding]; DNA binding site 205918000892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918000893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918000894 homodimer interface [polypeptide binding]; other site 205918000895 catalytic residue [active] 205918000896 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 205918000897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918000898 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918000899 Flagellin N-methylase; Region: FliB; cl00497 205918000900 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 205918000901 Helix-turn-helix domains; Region: HTH; cl00088 205918000902 AsnC family; Region: AsnC_trans_reg; pfam01037 205918000903 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 205918000904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918000905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918000906 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 205918000907 homotrimer interaction site [polypeptide binding]; other site 205918000908 putative active site [active] 205918000909 alanine racemase; Reviewed; Region: dadX; PRK03646 205918000910 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 205918000911 active site 205918000912 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918000913 substrate binding site [chemical binding]; other site 205918000914 catalytic residues [active] 205918000915 dimer interface [polypeptide binding]; other site 205918000916 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 205918000917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918000918 non-specific DNA binding site [nucleotide binding]; other site 205918000919 salt bridge; other site 205918000920 sequence-specific DNA binding site [nucleotide binding]; other site 205918000921 Cupin domain; Region: Cupin_2; cl09118 205918000922 Cytochrome c; Region: Cytochrom_C; cl11414 205918000923 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 205918000924 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 205918000925 Protein of unknown function (DUF962); Region: DUF962; cl01879 205918000926 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000927 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000928 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000929 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000930 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918000931 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 205918000932 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 205918000933 ligand binding site [chemical binding]; other site 205918000934 flexible hinge region; other site 205918000935 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 205918000936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918000937 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205918000938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000939 dimer interface [polypeptide binding]; other site 205918000940 conserved gate region; other site 205918000941 putative PBP binding loops; other site 205918000942 ABC-ATPase subunit interface; other site 205918000943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918000944 dimer interface [polypeptide binding]; other site 205918000945 conserved gate region; other site 205918000946 putative PBP binding loops; other site 205918000947 ABC-ATPase subunit interface; other site 205918000948 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000949 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000950 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000951 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000952 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000953 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000954 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000955 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000956 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000957 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000958 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000959 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918000960 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 205918000961 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 205918000962 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 205918000963 lipoyl attachment site [posttranslational modification]; other site 205918000964 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 205918000965 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 205918000966 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 205918000967 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918000968 Walker A motif; other site 205918000969 ATP binding site [chemical binding]; other site 205918000970 Walker B motif; other site 205918000971 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918000972 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918000973 putative DNA binding site [nucleotide binding]; other site 205918000974 putative Zn2+ binding site [ion binding]; other site 205918000975 AsnC family; Region: AsnC_trans_reg; pfam01037 205918000976 Uncharacterized conserved protein [Function unknown]; Region: COG3025 205918000977 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 205918000978 putative active site [active] 205918000979 putative metal binding residues [ion binding]; other site 205918000980 signature motif; other site 205918000981 putative triphosphate binding site [ion binding]; other site 205918000982 acetylornithine deacetylase; Provisional; Region: PRK05111 205918000983 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 205918000984 metal binding site [ion binding]; metal-binding site 205918000985 putative dimer interface [polypeptide binding]; other site 205918000986 N-acetylglutamate synthase; Validated; Region: PRK05279 205918000987 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 205918000988 putative feedback inhibition sensing region; other site 205918000989 putative nucleotide binding site [chemical binding]; other site 205918000990 putative substrate binding site [chemical binding]; other site 205918000991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918000992 Coenzyme A binding pocket [chemical binding]; other site 205918000993 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 205918000994 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 205918000995 CoenzymeA binding site [chemical binding]; other site 205918000996 subunit interaction site [polypeptide binding]; other site 205918000997 PHB binding site; other site 205918000998 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 205918000999 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 205918001000 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 205918001001 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 205918001002 RNA binding site [nucleotide binding]; other site 205918001003 osmolarity response regulator; Provisional; Region: ompR; PRK09468 205918001004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918001005 active site 205918001006 phosphorylation site [posttranslational modification] 205918001007 intermolecular recognition site; other site 205918001008 dimerization interface [polypeptide binding]; other site 205918001009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918001010 DNA binding site [nucleotide binding] 205918001011 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 205918001012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918001013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918001014 ATP binding site [chemical binding]; other site 205918001015 Mg2+ binding site [ion binding]; other site 205918001016 G-X-G motif; other site 205918001017 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001018 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001019 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428 205918001020 1 probable transmembrane helix predicted by TMHMM2.0 205918001021 BON domain; Region: BON; cl02771 205918001022 BON domain; Region: BON; cl02771 205918001023 BON domain; Region: BON; cl02771 205918001024 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918001025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918001026 active site 205918001027 phosphorylation site [posttranslational modification] 205918001028 intermolecular recognition site; other site 205918001029 dimerization interface [polypeptide binding]; other site 205918001030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918001031 Walker A motif; other site 205918001032 ATP binding site [chemical binding]; other site 205918001033 Walker B motif; other site 205918001034 arginine finger; other site 205918001035 Helix-turn-helix domains; Region: HTH; cl00088 205918001036 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918001037 dimerization interface [polypeptide binding]; other site 205918001038 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918001039 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 205918001040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918001041 dimer interface [polypeptide binding]; other site 205918001042 phosphorylation site [posttranslational modification] 205918001043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918001044 ATP binding site [chemical binding]; other site 205918001045 Mg2+ binding site [ion binding]; other site 205918001046 G-X-G motif; other site 205918001047 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001048 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001049 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 205918001050 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 205918001051 amidase catalytic site [active] 205918001052 Zn binding residues [ion binding]; other site 205918001053 substrate binding site [chemical binding]; other site 205918001054 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 205918001055 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205918001056 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918001057 metal binding site [ion binding]; metal-binding site 205918001058 active site 205918001059 I-site; other site 205918001060 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 205918001061 putative catalytic site [active] 205918001062 putative metal binding site [ion binding]; other site 205918001063 putative phosphate binding site [ion binding]; other site 205918001064 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 205918001065 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 205918001066 catalytic residues [active] 205918001067 hinge region; other site 205918001068 alpha helical domain; other site 205918001069 Predicted GTPase [General function prediction only]; Region: COG0218 205918001070 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 205918001071 G1 box; other site 205918001072 GTP/Mg2+ binding site [chemical binding]; other site 205918001073 Switch I region; other site 205918001074 G2 box; other site 205918001075 G3 box; other site 205918001076 Switch II region; other site 205918001077 G4 box; other site 205918001078 G5 box; other site 205918001079 DNA polymerase I; Provisional; Region: PRK05755 205918001080 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 205918001081 active site 205918001082 metal binding site 1 [ion binding]; metal-binding site 205918001083 putative 5' ssDNA interaction site; other site 205918001084 metal binding site 3; metal-binding site 205918001085 metal binding site 2 [ion binding]; metal-binding site 205918001086 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 205918001087 putative DNA binding site [nucleotide binding]; other site 205918001088 putative metal binding site [ion binding]; other site 205918001089 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 205918001090 active site 205918001091 catalytic site [active] 205918001092 substrate binding site [chemical binding]; other site 205918001093 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 205918001094 active site 205918001095 DNA binding site [nucleotide binding] 205918001096 catalytic site [active] 205918001097 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 205918001098 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 205918001099 Phosphotransferase enzyme family; Region: APH; pfam01636 205918001100 putative active site [active] 205918001101 putative substrate binding site [chemical binding]; other site 205918001102 ATP binding site [chemical binding]; other site 205918001103 putative transposase OrfB; Reviewed; Region: PHA02517 205918001104 HTH-like domain; Region: HTH_21; pfam13276 205918001105 Integrase core domain; Region: rve; cl01316 205918001106 Integrase core domain; Region: rve_3; cl15866 205918001107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918001108 Helix-turn-helix domains; Region: HTH; cl00088 205918001109 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 205918001110 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 205918001111 metal binding site [ion binding]; metal-binding site 205918001112 Helix-turn-helix domains; Region: HTH; cl00088 205918001113 metal binding site 2 [ion binding]; metal-binding site 205918001114 putative DNA binding helix; other site 205918001115 metal binding site 1 [ion binding]; metal-binding site 205918001116 dimer interface [polypeptide binding]; other site 205918001117 structural Zn2+ binding site [ion binding]; other site 205918001118 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 205918001119 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 205918001120 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918001121 dimer interface [polypeptide binding]; other site 205918001122 putative PBP binding regions; other site 205918001123 ABC-ATPase subunit interface; other site 205918001124 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001125 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001126 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001127 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001128 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001129 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001130 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001131 hydroperoxidase II; Provisional; Region: katE; PRK11249 205918001132 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 205918001133 tetramer interface [polypeptide binding]; other site 205918001134 heme binding pocket [chemical binding]; other site 205918001135 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 205918001136 domain interactions; other site 205918001137 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 205918001138 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 205918001139 Walker A/P-loop; other site 205918001140 ATP binding site [chemical binding]; other site 205918001141 Q-loop/lid; other site 205918001142 ABC transporter signature motif; other site 205918001143 Walker B; other site 205918001144 D-loop; other site 205918001145 H-loop/switch region; other site 205918001146 NIL domain; Region: NIL; cl09633 205918001147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918001148 conserved gate region; other site 205918001149 ABC-ATPase subunit interface; other site 205918001150 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001151 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001152 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001153 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001154 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001155 NMT1-like family; Region: NMT1_2; cl15260 205918001156 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 205918001157 Cu(I) binding site [ion binding]; other site 205918001158 1 probable transmembrane helix predicted by TMHMM2.0 205918001159 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 205918001160 1 probable transmembrane helix predicted by TMHMM2.0 205918001161 Sulfate transporter family; Region: Sulfate_transp; cl15842 205918001162 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 205918001163 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001164 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001165 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001166 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001167 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001168 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001169 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001170 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001171 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001172 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001173 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 205918001174 active site clefts [active] 205918001175 zinc binding site [ion binding]; other site 205918001176 dimer interface [polypeptide binding]; other site 205918001177 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 205918001178 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918001179 FeS/SAM binding site; other site 205918001180 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 205918001181 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 205918001182 conserved cys residue [active] 205918001183 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 205918001184 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001185 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001186 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001187 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001188 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001189 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 205918001190 dimer interface [polypeptide binding]; other site 205918001191 active site 205918001192 aspartate-rich active site metal binding site; other site 205918001193 allosteric magnesium binding site [ion binding]; other site 205918001194 Schiff base residues; other site 205918001195 polyphosphate kinase; Provisional; Region: PRK05443 205918001196 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 205918001197 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 205918001198 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 205918001199 putative active site [active] 205918001200 catalytic site [active] 205918001201 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 205918001202 putative domain interface [polypeptide binding]; other site 205918001203 putative active site [active] 205918001204 catalytic site [active] 205918001205 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 205918001206 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 205918001207 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918001208 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 205918001209 Walker A/P-loop; other site 205918001210 ATP binding site [chemical binding]; other site 205918001211 Q-loop/lid; other site 205918001212 ABC transporter signature motif; other site 205918001213 Walker B; other site 205918001214 D-loop; other site 205918001215 H-loop/switch region; other site 205918001216 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918001217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918001218 dimer interface [polypeptide binding]; other site 205918001219 conserved gate region; other site 205918001220 putative PBP binding loops; other site 205918001221 ABC-ATPase subunit interface; other site 205918001222 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001223 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001224 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001225 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001226 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001227 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918001228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918001229 dimer interface [polypeptide binding]; other site 205918001230 conserved gate region; other site 205918001231 putative PBP binding loops; other site 205918001232 ABC-ATPase subunit interface; other site 205918001233 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001234 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001235 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001236 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918001237 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918001238 substrate binding pocket [chemical binding]; other site 205918001239 membrane-bound complex binding site; other site 205918001240 hinge residues; other site 205918001241 Transcriptional regulators [Transcription]; Region: FadR; COG2186 205918001242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918001243 DNA-binding site [nucleotide binding]; DNA binding site 205918001244 FCD domain; Region: FCD; cl11656 205918001245 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 205918001246 catalytic residues [active] 205918001247 transcription termination factor Rho; Provisional; Region: rho; PRK09376 205918001248 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 205918001249 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 205918001250 RNA binding site [nucleotide binding]; other site 205918001251 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 205918001252 multimer interface [polypeptide binding]; other site 205918001253 Walker A motif; other site 205918001254 ATP binding site [chemical binding]; other site 205918001255 Walker B motif; other site 205918001256 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 205918001257 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 205918001258 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205918001259 catalytic loop [active] 205918001260 iron binding site [ion binding]; other site 205918001261 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 205918001262 FAD binding pocket [chemical binding]; other site 205918001263 FAD binding motif [chemical binding]; other site 205918001264 phosphate binding motif [ion binding]; other site 205918001265 beta-alpha-beta structure motif; other site 205918001266 NAD binding pocket [chemical binding]; other site 205918001267 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 205918001268 putative active site pocket [active] 205918001269 dimerization interface [polypeptide binding]; other site 205918001270 putative catalytic residue [active] 205918001271 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 205918001272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918001273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918001274 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001275 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001276 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001277 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001278 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001279 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001280 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001281 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001282 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001283 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001284 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001285 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001286 Gram-negative bacterial tonB protein; Region: TonB; cl10048 205918001287 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 205918001288 S-type Pyocin; Region: Pyocin_S; pfam06958 205918001289 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 205918001290 active site 205918001291 oxidoreductase, zinc-binding 205918001292 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 205918001293 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 205918001294 NAD(P) binding site [chemical binding]; other site 205918001295 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 205918001296 EVE domain; Region: EVE; cl00728 205918001297 1 probable transmembrane helix predicted by TMHMM2.0 205918001298 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 205918001299 Cell division protein ZapA; Region: ZapA; cl01146 205918001300 TIGR02449 family protein; Region: TIGR02449 205918001301 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 205918001302 proline aminopeptidase P II; Provisional; Region: PRK10879 205918001303 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 205918001304 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 205918001305 active site 205918001306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918001307 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 205918001308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918001309 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 205918001310 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 205918001311 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918001312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918001313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918001314 D-galactonate transporter; Region: 2A0114; TIGR00893 205918001315 putative substrate translocation pore; other site 205918001316 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001317 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001318 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001319 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001320 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001321 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001322 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001323 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001324 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001325 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001326 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918001327 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 205918001328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918001329 Walker A motif; other site 205918001330 ATP binding site [chemical binding]; other site 205918001331 Walker B motif; other site 205918001332 arginine finger; other site 205918001333 NMT1-like family; Region: NMT1_2; cl15260 205918001334 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918001335 Secretory lipase; Region: LIP; pfam03583 205918001336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918001337 S-adenosylmethionine binding site [chemical binding]; other site 205918001338 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 205918001339 AMP-binding enzyme; Region: AMP-binding; cl15778 205918001340 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 205918001341 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918001342 active site 205918001343 Cupin domain; Region: Cupin_2; cl09118 205918001344 H+ Antiporter protein; Region: 2A0121; TIGR00900 205918001345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918001346 putative substrate translocation pore; other site 205918001347 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001348 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001349 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001350 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001351 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001352 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001353 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001354 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001355 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001356 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001357 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 205918001358 active site 205918001359 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 205918001360 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 205918001361 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 205918001362 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 205918001363 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 205918001364 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 205918001365 Walker A/P-loop; other site 205918001366 ATP binding site [chemical binding]; other site 205918001367 Q-loop/lid; other site 205918001368 ABC transporter signature motif; other site 205918001369 Walker B; other site 205918001370 D-loop; other site 205918001371 H-loop/switch region; other site 205918001372 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 205918001373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918001374 dimer interface [polypeptide binding]; other site 205918001375 conserved gate region; other site 205918001376 putative PBP binding loops; other site 205918001377 ABC-ATPase subunit interface; other site 205918001378 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001379 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001380 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001381 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001382 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001383 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001384 NMT1-like family; Region: NMT1_2; cl15260 205918001385 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918001386 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918001387 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001388 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001389 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918001390 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001391 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001392 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918001393 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918001394 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918001395 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918001396 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918001397 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 205918001398 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001399 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001400 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001401 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001402 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001403 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001404 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001405 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001406 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001407 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001408 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001409 Methyltransferase domain; Region: Methyltransf_31; pfam13847 205918001410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918001411 S-adenosylmethionine binding site [chemical binding]; other site 205918001412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918001413 dimer interface [polypeptide binding]; other site 205918001414 conserved gate region; other site 205918001415 ABC-ATPase subunit interface; other site 205918001416 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001417 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001418 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001419 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001420 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001421 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 205918001422 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 205918001423 Walker A/P-loop; other site 205918001424 ATP binding site [chemical binding]; other site 205918001425 Q-loop/lid; other site 205918001426 ABC transporter signature motif; other site 205918001427 Walker B; other site 205918001428 D-loop; other site 205918001429 H-loop/switch region; other site 205918001430 NIL domain; Region: NIL; cl09633 205918001431 NMT1-like family; Region: NMT1_2; cl15260 205918001432 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 205918001433 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 205918001434 active site 205918001435 non-prolyl cis peptide bond; other site 205918001436 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 205918001437 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 205918001438 Flavin binding site [chemical binding]; other site 205918001439 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 205918001440 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918001441 active site 205918001442 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 205918001443 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 205918001444 Walker A/P-loop; other site 205918001445 ATP binding site [chemical binding]; other site 205918001446 Q-loop/lid; other site 205918001447 ABC transporter signature motif; other site 205918001448 Walker B; other site 205918001449 D-loop; other site 205918001450 H-loop/switch region; other site 205918001451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918001452 dimer interface [polypeptide binding]; other site 205918001453 conserved gate region; other site 205918001454 putative PBP binding loops; other site 205918001455 ABC-ATPase subunit interface; other site 205918001456 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001457 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001458 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001459 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001460 cystine transporter subunit; Provisional; Region: PRK11260 205918001461 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918001462 substrate binding pocket [chemical binding]; other site 205918001463 membrane-bound complex binding site; other site 205918001464 hinge residues; other site 205918001465 D-cysteine desulfhydrase; Validated; Region: PRK03910 205918001466 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 205918001467 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918001468 catalytic residue [active] 205918001469 serine O-acetyltransferase; Region: cysE; TIGR01172 205918001470 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 205918001471 trimer interface [polypeptide binding]; other site 205918001472 active site 205918001473 substrate binding site [chemical binding]; other site 205918001474 CoA binding site [chemical binding]; other site 205918001475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 205918001476 Anti-sigma-K factor rskA; Region: RskA; pfam10099 205918001477 1 probable transmembrane helix predicted by TMHMM2.0 205918001478 RNA polymerase sigma factor; Provisional; Region: PRK12537 205918001479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918001480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918001481 DNA binding residues [nucleotide binding] 205918001482 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 205918001483 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 205918001484 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001485 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001486 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001487 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001488 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001489 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001490 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001491 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001492 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001493 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001494 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001495 HutD; Region: HutD; cl01532 205918001496 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 205918001497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918001498 DNA-binding site [nucleotide binding]; DNA binding site 205918001499 UTRA domain; Region: UTRA; cl01230 205918001500 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 205918001501 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 205918001502 active site 205918001503 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 205918001504 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 205918001505 fructose-1,6-bisphosphatase family protein; Region: PLN02628 205918001506 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 205918001507 AMP binding site [chemical binding]; other site 205918001508 metal binding site [ion binding]; metal-binding site 205918001509 active site 205918001510 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 205918001511 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 205918001512 1 probable transmembrane helix predicted by TMHMM2.0 205918001513 membrane protein 205918001514 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001515 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001516 membrane protein 205918001517 1 probable transmembrane helix predicted by TMHMM2.0 205918001518 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 205918001519 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 205918001520 homodimer interface [polypeptide binding]; other site 205918001521 active site pocket [active] 205918001522 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 205918001523 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918001524 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 205918001525 putative active site [active] 205918001526 dimerization interface [polypeptide binding]; other site 205918001527 putative tRNAtyr binding site [nucleotide binding]; other site 205918001528 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 205918001529 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 205918001530 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 205918001531 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 205918001532 Ligand binding site; other site 205918001533 DXD motif; other site 205918001534 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001535 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001536 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001537 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001538 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001539 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001540 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918001541 dimerization interface [polypeptide binding]; other site 205918001542 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918001543 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918001544 dimer interface [polypeptide binding]; other site 205918001545 putative CheW interface [polypeptide binding]; other site 205918001546 1 probable transmembrane helix predicted by TMHMM2.0 205918001547 Peptidase S46; Region: Peptidase_S46; pfam10459 205918001548 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 205918001549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918001550 dimerization interface [polypeptide binding]; other site 205918001551 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918001552 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918001553 dimer interface [polypeptide binding]; other site 205918001554 putative CheW interface [polypeptide binding]; other site 205918001555 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001556 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 205918001558 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 205918001559 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 205918001560 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001561 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001562 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001563 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001564 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918001565 sec-independent translocase; Provisional; Region: tatB; PRK00404 205918001566 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 205918001567 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 205918001568 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 205918001569 metal binding site [ion binding]; metal-binding site 205918001570 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 205918001571 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 205918001572 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918001573 1 probable transmembrane helix predicted by TMHMM2.0 205918001574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 205918001575 SCP-2 sterol transfer family; Region: SCP2; cl01225 205918001576 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 205918001577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918001578 S-adenosylmethionine binding site [chemical binding]; other site 205918001579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918001580 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 205918001581 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 205918001582 Protein of unknown function (DUF971); Region: DUF971; cl01414 205918001583 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 205918001584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918001585 Walker A motif; other site 205918001586 ATP binding site [chemical binding]; other site 205918001587 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918001588 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 205918001589 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 205918001590 active site 205918001591 HslU subunit interaction site [polypeptide binding]; other site 205918001592 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 205918001593 Sporulation related domain; Region: SPOR; cl10051 205918001594 1 probable transmembrane helix predicted by TMHMM2.0 205918001595 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 205918001596 arginine-tRNA ligase; Region: PLN02286 205918001597 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 205918001598 active site 205918001599 HIGH motif; other site 205918001600 KMSK motif region; other site 205918001601 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 205918001602 tRNA binding surface [nucleotide binding]; other site 205918001603 anticodon binding site; other site 205918001604 primosome assembly protein PriA; Validated; Region: PRK05580 205918001605 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918001606 ATP binding site [chemical binding]; other site 205918001607 putative Mg++ binding site [ion binding]; other site 205918001608 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918001609 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 205918001610 Staphylococcal nuclease homologues; Region: SNc; smart00318 205918001611 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 205918001612 Catalytic site; other site 205918001613 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 205918001614 Malic enzyme, N-terminal domain; Region: malic; pfam00390 205918001615 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 205918001616 putative NAD(P) binding site [chemical binding]; other site 205918001617 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 205918001618 Transglycosylase; Region: Transgly; cl07896 205918001619 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918001620 1 probable transmembrane helix predicted by TMHMM2.0 205918001621 Competence protein A; Region: Competence_A; pfam11104 205918001622 Cell division protein FtsA; Region: FtsA; cl11496 205918001623 Cell division protein FtsA; Region: FtsA; cl11496 205918001624 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 205918001625 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 205918001626 1 probable transmembrane helix predicted by TMHMM2.0 205918001627 Pilus assembly protein, PilO; Region: PilO; cl01234 205918001628 1 probable transmembrane helix predicted by TMHMM2.0 205918001629 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 205918001630 Pilus assembly protein, PilP; Region: PilP; pfam04351 205918001631 AMIN domain; Region: AMIN; pfam11741 205918001632 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 205918001633 Secretin and TonB N terminus short domain; Region: STN; cl06624 205918001634 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918001635 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 205918001636 1 probable transmembrane helix predicted by TMHMM2.0 205918001637 shikimate kinase; Reviewed; Region: aroK; PRK00131 205918001638 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 205918001639 ADP binding site [chemical binding]; other site 205918001640 magnesium binding site [ion binding]; other site 205918001641 putative shikimate binding site; other site 205918001642 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 205918001643 active site 205918001644 dimer interface [polypeptide binding]; other site 205918001645 metal binding site [ion binding]; metal-binding site 205918001646 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 205918001647 Sporulation related domain; Region: SPOR; cl10051 205918001648 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 205918001649 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 205918001650 active site 205918001651 dimer interface [polypeptide binding]; other site 205918001652 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 205918001653 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 205918001654 active site 205918001655 FMN binding site [chemical binding]; other site 205918001656 substrate binding site [chemical binding]; other site 205918001657 3Fe-4S cluster binding site [ion binding]; other site 205918001658 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 205918001659 domain interface; other site 205918001660 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 205918001661 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 205918001662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918001663 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 205918001664 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 205918001665 substrate binding site [chemical binding]; other site 205918001666 active site 205918001667 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 205918001668 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 205918001669 active site 205918001670 putative substrate binding pocket [chemical binding]; other site 205918001671 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 205918001672 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 205918001673 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 205918001674 putative active site [active] 205918001675 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 205918001676 GntP family permease; Region: GntP_permease; pfam02447 205918001677 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001678 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001679 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001680 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001681 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001682 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001683 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001684 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001685 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001686 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001687 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001688 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001689 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 205918001690 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 205918001691 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918001692 Walker A/P-loop; other site 205918001693 ATP binding site [chemical binding]; other site 205918001694 Q-loop/lid; other site 205918001695 ABC transporter signature motif; other site 205918001696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918001697 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 205918001698 putative substrate translocation pore; other site 205918001699 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001700 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001701 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001702 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001703 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001704 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001705 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001706 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001707 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001708 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001709 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001710 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918001711 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 205918001712 Helix-turn-helix domains; Region: HTH; cl00088 205918001713 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 205918001714 dimerization interface [polypeptide binding]; other site 205918001715 substrate binding pocket [chemical binding]; other site 205918001716 1 probable transmembrane helix predicted by TMHMM2.0 205918001717 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 205918001718 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 205918001719 dimer interface [polypeptide binding]; other site 205918001720 active site 205918001721 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 205918001722 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 205918001723 NAD(P) binding site [chemical binding]; other site 205918001724 homotetramer interface [polypeptide binding]; other site 205918001725 homodimer interface [polypeptide binding]; other site 205918001726 active site 205918001727 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 205918001728 putative active site 1 [active] 205918001729 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 205918001730 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 205918001731 dimer interface [polypeptide binding]; other site 205918001732 active site 205918001733 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 205918001734 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 205918001735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918001736 S-adenosylmethionine binding site [chemical binding]; other site 205918001737 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 205918001738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918001739 Predicted exporter [General function prediction only]; Region: COG4258 205918001740 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001741 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001742 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001743 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001744 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001745 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001746 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001747 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001748 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001749 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918001750 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 205918001751 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 205918001752 active site 205918001753 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 205918001754 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 205918001755 putative acyl-acceptor binding pocket; other site 205918001756 1 probable transmembrane helix predicted by TMHMM2.0 205918001757 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 205918001758 Ligand binding site; other site 205918001759 Putative Catalytic site; other site 205918001760 DXD motif; other site 205918001761 AMP-binding enzyme; Region: AMP-binding; cl15778 205918001762 peptide synthase; Validated; Region: PRK05691 205918001763 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 205918001764 active site 2 [active] 205918001765 dimer interface [polypeptide binding]; other site 205918001766 active site 1 [active] 205918001767 Predicted membrane protein [Function unknown]; Region: COG4648 205918001768 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001769 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001770 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001771 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001772 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001773 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918001774 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918001775 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918001776 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 205918001777 putative acyl-acceptor binding pocket; other site 205918001778 1 probable transmembrane helix predicted by TMHMM2.0 205918001779 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 205918001780 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205918001781 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 205918001782 P loop; other site 205918001783 Nucleotide binding site [chemical binding]; other site 205918001784 DTAP/Switch II; other site 205918001785 Switch I; other site 205918001786 PAAR motif; Region: PAAR_motif; cl15808 205918001787 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 205918001788 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 205918001789 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 205918001790 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 205918001791 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 205918001792 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913 205918001793 Acyl transferase domain; Region: Acyl_transf_1; cl08282 205918001794 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 205918001795 Malonate transporter MadL subunit; Region: MadL; cl04273 205918001796 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001797 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001798 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001799 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001800 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 205918001801 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001802 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001803 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001804 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001805 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001806 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001807 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001808 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918001809 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918001810 Helix-turn-helix domains; Region: HTH; cl00088 205918001811 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 205918001812 putative dimerization interface [polypeptide binding]; other site 205918001813 Haemolysin-III related; Region: HlyIII; cl03831 205918001814 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001815 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001816 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001817 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001818 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001819 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001820 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918001821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 205918001822 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 205918001823 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 205918001824 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918001825 inhibitor-cofactor binding pocket; inhibition site 205918001826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918001827 catalytic residue [active] 205918001828 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 205918001829 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 205918001830 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001831 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001832 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001833 YceI-like domain; Region: YceI; cl01001 205918001834 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 205918001835 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 205918001836 ATP binding site [chemical binding]; other site 205918001837 Mg++ binding site [ion binding]; other site 205918001838 motif III; other site 205918001839 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918001840 nucleotide binding region [chemical binding]; other site 205918001841 ATP-binding site [chemical binding]; other site 205918001842 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 205918001843 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 205918001844 FAD binding site [chemical binding]; other site 205918001845 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 205918001846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918001847 oligomerization interface [polypeptide binding]; other site 205918001848 active site 205918001849 NAD+ binding site [chemical binding]; other site 205918001850 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 205918001851 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 205918001852 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 205918001853 GntP family permease; Region: GntP_permease; pfam02447 205918001854 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001855 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001856 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001857 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001858 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001859 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001860 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001861 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001862 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001863 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001864 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001865 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 205918001866 intersubunit interface [polypeptide binding]; other site 205918001867 active site 205918001868 Zn2+ binding site [ion binding]; other site 205918001869 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 205918001870 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 205918001871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918001872 Flagellin N-methylase; Region: FliB; cl00497 205918001873 aminotransferase; Validated; Region: PRK08175 205918001874 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918001875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918001876 homodimer interface [polypeptide binding]; other site 205918001877 catalytic residue [active] 205918001878 Dehydratase family; Region: ILVD_EDD; cl00340 205918001879 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 205918001880 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001881 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001882 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918001883 HemN family oxidoreductase; Provisional; Region: PRK05660 205918001884 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918001885 FeS/SAM binding site; other site 205918001886 HemN C-terminal domain; Region: HemN_C; pfam06969 205918001887 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 205918001888 active site 205918001889 dimerization interface [polypeptide binding]; other site 205918001890 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 205918001891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918001892 S-adenosylmethionine binding site [chemical binding]; other site 205918001893 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 205918001894 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918001895 YGGT family; Region: YGGT; cl00508 205918001896 YGGT family; Region: YGGT; cl00508 205918001897 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001898 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001899 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001900 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001901 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 205918001902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918001903 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 205918001904 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918001905 catalytic residue [active] 205918001906 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 205918001907 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 205918001908 Walker A motif; other site 205918001909 ATP binding site [chemical binding]; other site 205918001910 Walker B motif; other site 205918001911 NlpC/P60 family; Region: NLPC_P60; cl11438 205918001912 TM2 domain; Region: TM2; cl00984 205918001913 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001914 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001915 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001916 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918001917 dihydroorotase; Validated; Region: pyrC; PRK09357 205918001918 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 205918001919 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 205918001920 active site 205918001921 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 205918001922 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 205918001923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918001924 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918001925 active site 205918001926 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 205918001927 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 205918001928 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 205918001929 Gram-negative bacterial tonB protein; Region: TonB; cl10048 205918001930 1 probable transmembrane helix predicted by TMHMM2.0 205918001931 glutathione synthetase; Provisional; Region: PRK05246 205918001932 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 205918001933 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918001934 Response regulator receiver domain; Region: Response_reg; pfam00072 205918001935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918001936 active site 205918001937 phosphorylation site [posttranslational modification] 205918001938 intermolecular recognition site; other site 205918001939 dimerization interface [polypeptide binding]; other site 205918001940 Response regulator receiver domain; Region: Response_reg; pfam00072 205918001941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918001942 active site 205918001943 phosphorylation site [posttranslational modification] 205918001944 intermolecular recognition site; other site 205918001945 dimerization interface [polypeptide binding]; other site 205918001946 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 205918001947 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 205918001948 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918001949 dimer interface [polypeptide binding]; other site 205918001950 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 205918001951 putative CheW interface [polypeptide binding]; other site 205918001952 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001953 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918001954 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 205918001955 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918001956 putative binding surface; other site 205918001957 active site 205918001958 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918001959 putative binding surface; other site 205918001960 active site 205918001961 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 205918001962 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918001963 putative binding surface; other site 205918001964 active site 205918001965 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918001966 putative binding surface; other site 205918001967 active site 205918001968 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 205918001969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918001970 ATP binding site [chemical binding]; other site 205918001971 Mg2+ binding site [ion binding]; other site 205918001972 G-X-G motif; other site 205918001973 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 205918001974 Response regulator receiver domain; Region: Response_reg; pfam00072 205918001975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918001976 active site 205918001977 phosphorylation site [posttranslational modification] 205918001978 intermolecular recognition site; other site 205918001979 dimerization interface [polypeptide binding]; other site 205918001980 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 205918001981 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 205918001982 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918001983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918001984 DNA-binding site [nucleotide binding]; DNA binding site 205918001985 FCD domain; Region: FCD; cl11656 205918001986 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 205918001987 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001988 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001989 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001990 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001991 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001992 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001993 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001994 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001995 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001996 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001997 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918001998 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 205918001999 putative active site [active] 205918002000 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 205918002001 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 205918002002 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 205918002003 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 205918002004 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 205918002005 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918002006 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918002007 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 205918002008 oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108 205918002009 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 205918002010 carboxyltransferase (CT) interaction site; other site 205918002011 biotinylation site [posttranslational modification]; other site 205918002012 hypothetical protein; Provisional; Region: PRK11281 205918002013 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 205918002014 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918002015 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002016 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002017 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002018 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002019 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002020 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002021 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002022 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002023 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002024 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002025 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002026 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002027 potassium/proton antiporter; Reviewed; Region: PRK05326 205918002028 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 205918002029 Transporter associated domain; Region: CorC_HlyC; cl08393 205918002030 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002031 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002032 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002033 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002034 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002035 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002036 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002037 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002038 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002039 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002040 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002041 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002042 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 205918002043 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 205918002044 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 205918002045 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 205918002046 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918002047 active site 205918002048 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 205918002049 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 205918002050 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 205918002051 Proline dehydrogenase; Region: Pro_dh; cl03282 205918002052 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 205918002053 Glutamate binding site [chemical binding]; other site 205918002054 NAD binding site [chemical binding]; other site 205918002055 catalytic residues [active] 205918002056 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 205918002057 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 205918002058 Na binding site [ion binding]; other site 205918002059 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002060 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002061 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002062 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002063 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002064 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002065 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002066 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002067 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002068 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002069 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002070 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002071 Alginate lyase; Region: Alginate_lyase2; pfam08787 205918002072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918002073 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 205918002074 active site 205918002075 phosphorylation site [posttranslational modification] 205918002076 intermolecular recognition site; other site 205918002077 dimerization interface [polypeptide binding]; other site 205918002078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918002079 putative active site [active] 205918002080 heme pocket [chemical binding]; other site 205918002081 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918002082 metal binding site [ion binding]; metal-binding site 205918002083 active site 205918002084 I-site; other site 205918002085 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918002086 Protein of unknown function DUF45; Region: DUF45; cl00636 205918002087 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 205918002088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918002089 Coenzyme A binding pocket [chemical binding]; other site 205918002090 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918002091 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918002092 substrate binding pocket [chemical binding]; other site 205918002093 membrane-bound complex binding site; other site 205918002094 hinge residues; other site 205918002095 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 205918002096 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 205918002097 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 205918002098 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002099 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002100 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002101 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002102 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002103 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002104 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002105 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002106 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002107 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918002109 HI0933-like protein; Region: HI0933_like; pfam03486 205918002110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918002111 1 probable transmembrane helix predicted by TMHMM2.0 205918002112 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 205918002113 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 205918002114 ATP binding site [chemical binding]; other site 205918002115 Mg++ binding site [ion binding]; other site 205918002116 motif III; other site 205918002117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918002118 nucleotide binding region [chemical binding]; other site 205918002119 ATP-binding site [chemical binding]; other site 205918002120 DbpA RNA binding domain; Region: DbpA; pfam03880 205918002121 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 205918002122 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 205918002123 E3 interaction surface; other site 205918002124 lipoyl attachment site [posttranslational modification]; other site 205918002125 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 205918002126 E3 interaction surface; other site 205918002127 lipoyl attachment site [posttranslational modification]; other site 205918002128 e3 binding domain; Region: E3_binding; pfam02817 205918002129 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 205918002130 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 205918002131 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 205918002132 dimer interface [polypeptide binding]; other site 205918002133 TPP-binding site [chemical binding]; other site 205918002134 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 205918002135 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205918002136 metal binding triad; other site 205918002137 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 205918002138 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205918002139 metal binding triad; other site 205918002140 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 205918002141 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 205918002142 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 205918002143 putative active site [active] 205918002144 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 205918002145 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 205918002146 putative active site [active] 205918002147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918002148 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 205918002149 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918002150 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918002151 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918002152 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 205918002153 active site 205918002154 ATP binding site [chemical binding]; other site 205918002155 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918002156 ATP binding site [chemical binding]; other site 205918002157 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 205918002158 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 205918002159 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 205918002160 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 205918002161 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 205918002162 putative ADP-binding pocket [chemical binding]; other site 205918002163 Mig-14; Region: Mig-14; pfam07395 205918002164 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918002165 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 205918002166 1 probable transmembrane helix predicted by TMHMM2.0 205918002167 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 205918002168 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918002169 active site 205918002170 1 probable transmembrane helix predicted by TMHMM2.0 205918002171 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002172 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002173 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002174 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002175 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002176 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002177 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002178 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002179 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002180 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002181 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002182 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002183 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918002184 active site 205918002185 ATP binding site [chemical binding]; other site 205918002186 1 probable transmembrane helix predicted by TMHMM2.0 205918002187 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 205918002188 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205918002189 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 205918002190 Walker A/P-loop; other site 205918002191 ATP binding site [chemical binding]; other site 205918002192 Q-loop/lid; other site 205918002193 ABC transporter signature motif; other site 205918002194 Walker B; other site 205918002195 D-loop; other site 205918002196 H-loop/switch region; other site 205918002197 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002198 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002199 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002200 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002201 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002202 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 205918002203 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 205918002204 putative ribose interaction site [chemical binding]; other site 205918002205 putative ADP binding site [chemical binding]; other site 205918002206 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205918002207 active site 205918002208 nucleotide binding site [chemical binding]; other site 205918002209 HIGH motif; other site 205918002210 KMSKS motif; other site 205918002211 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918002212 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 205918002213 active site 205918002214 catalytic tetrad [active] 205918002215 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 205918002216 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 205918002217 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002218 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002219 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002220 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 205918002221 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 205918002222 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 205918002223 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 205918002224 ThiC-associated domain; Region: ThiC-associated; pfam13667 205918002225 ThiC family; Region: ThiC; cl08031 205918002226 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 205918002227 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 205918002228 Na binding site [ion binding]; other site 205918002229 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002230 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002231 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002232 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002233 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002234 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002235 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002236 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002237 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002238 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002239 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002240 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002241 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 205918002242 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 205918002243 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 205918002244 dimer interface [polypeptide binding]; other site 205918002245 ADP-ribose binding site [chemical binding]; other site 205918002246 active site 205918002247 nudix motif; other site 205918002248 metal binding site [ion binding]; metal-binding site 205918002249 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 205918002250 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 205918002251 hexamer interface [polypeptide binding]; other site 205918002252 active site 205918002253 metal binding site [ion binding]; metal-binding site 205918002254 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 205918002255 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 205918002256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918002257 ATP binding site [chemical binding]; other site 205918002258 Mg2+ binding site [ion binding]; other site 205918002259 G-X-G motif; other site 205918002260 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 205918002261 anchoring element; other site 205918002262 dimer interface [polypeptide binding]; other site 205918002263 ATP binding site [chemical binding]; other site 205918002264 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 205918002265 active site 205918002266 metal binding site [ion binding]; metal-binding site 205918002267 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 205918002268 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 205918002269 SdiA-regulated; Region: SdiA-regulated; cd09971 205918002270 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 205918002271 catalytic motif [active] 205918002272 Catalytic residue [active] 205918002273 1 probable transmembrane helix predicted by TMHMM2.0 205918002274 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 205918002275 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 205918002276 CAP-like domain; other site 205918002277 active site 205918002278 primary dimer interface [polypeptide binding]; other site 205918002279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 205918002280 Protein of unknown function (DUF330); Region: DUF330; cl01135 205918002281 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 205918002282 1 probable transmembrane helix predicted by TMHMM2.0 205918002283 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 205918002284 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 205918002285 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 205918002286 phosphoserine phosphatase SerB; Region: serB; TIGR00338 205918002287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918002288 motif II; other site 205918002289 bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional; Region: PRK09629 205918002290 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 205918002291 active site residue [active] 205918002292 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 205918002293 active site residue [active] 205918002294 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 205918002295 HDOD domain; Region: HDOD; pfam08668 205918002296 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 205918002297 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 205918002298 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918002299 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918002300 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918002301 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918002302 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 205918002303 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 205918002304 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918002305 ligand binding site [chemical binding]; other site 205918002306 1 probable transmembrane helix predicted by TMHMM2.0 205918002307 GTPase RsgA; Reviewed; Region: PRK12288 205918002308 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205918002309 RNA binding site [nucleotide binding]; other site 205918002310 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 205918002311 GTPase/Zn-binding domain interface [polypeptide binding]; other site 205918002312 GTP/Mg2+ binding site [chemical binding]; other site 205918002313 G4 box; other site 205918002314 G5 box; other site 205918002315 G1 box; other site 205918002316 Switch I region; other site 205918002317 G2 box; other site 205918002318 G3 box; other site 205918002319 Switch II region; other site 205918002320 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 205918002321 catalytic site [active] 205918002322 putative active site [active] 205918002323 putative substrate binding site [chemical binding]; other site 205918002324 dimer interface [polypeptide binding]; other site 205918002325 Predicted membrane protein [Function unknown]; Region: COG2860 205918002326 UPF0126 domain; Region: UPF0126; pfam03458 205918002327 UPF0126 domain; Region: UPF0126; pfam03458 205918002328 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002329 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002330 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002331 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002332 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002333 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002334 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002335 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 205918002336 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 205918002337 putative carbohydrate kinase; Provisional; Region: PRK10565 205918002338 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 205918002339 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 205918002340 putative substrate binding site [chemical binding]; other site 205918002341 putative ATP binding site [chemical binding]; other site 205918002342 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 205918002343 AMIN domain; Region: AMIN; pfam11741 205918002344 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 205918002345 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 205918002346 active site 205918002347 metal binding site [ion binding]; metal-binding site 205918002348 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918002349 1 probable transmembrane helix predicted by TMHMM2.0 205918002350 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 205918002351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918002352 ATP binding site [chemical binding]; other site 205918002353 Mg2+ binding site [ion binding]; other site 205918002354 G-X-G motif; other site 205918002355 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 205918002356 ATP binding site [chemical binding]; other site 205918002357 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 205918002358 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 205918002359 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918002360 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 205918002361 Sm1 motif; other site 205918002362 intra - hexamer interaction site; other site 205918002363 inter - hexamer interaction site [polypeptide binding]; other site 205918002364 nucleotide binding pocket [chemical binding]; other site 205918002365 Sm2 motif; other site 205918002366 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 205918002367 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 205918002368 HflX GTPase family; Region: HflX; cd01878 205918002369 G1 box; other site 205918002370 GTP/Mg2+ binding site [chemical binding]; other site 205918002371 Switch I region; other site 205918002372 G2 box; other site 205918002373 G3 box; other site 205918002374 Switch II region; other site 205918002375 G4 box; other site 205918002376 G5 box; other site 205918002377 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 205918002378 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 205918002379 HflK protein; Region: hflK; TIGR01933 205918002380 1 probable transmembrane helix predicted by TMHMM2.0 205918002381 FtsH protease regulator HflC; Provisional; Region: PRK11029 205918002382 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 205918002383 1 probable transmembrane helix predicted by TMHMM2.0 205918002384 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 205918002385 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 205918002386 dimer interface [polypeptide binding]; other site 205918002387 motif 1; other site 205918002388 active site 205918002389 motif 2; other site 205918002390 motif 3; other site 205918002391 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 205918002392 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 205918002393 GDP-binding site [chemical binding]; other site 205918002394 ACT binding site; other site 205918002395 IMP binding site; other site 205918002396 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918002397 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918002398 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918002399 dimer interface [polypeptide binding]; other site 205918002400 putative CheW interface [polypeptide binding]; other site 205918002401 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918002402 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918002403 ribonuclease R; Region: RNase_R; TIGR02063 205918002404 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205918002405 RNB domain; Region: RNB; pfam00773 205918002406 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 205918002407 RNA binding site [nucleotide binding]; other site 205918002408 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 205918002409 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 205918002410 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 205918002411 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 205918002412 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 205918002413 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002414 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002415 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002416 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002417 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002418 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002419 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002420 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 205918002421 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 205918002422 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 205918002423 replicative DNA helicase; Provisional; Region: PRK05748 205918002424 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 205918002425 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 205918002426 Walker A motif; other site 205918002427 ATP binding site [chemical binding]; other site 205918002428 Walker B motif; other site 205918002429 DNA binding loops [nucleotide binding] 205918002430 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918002431 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918002432 1 probable transmembrane helix predicted by TMHMM2.0 205918002433 hypothetical protein; Provisional; Region: PRK01254 205918002434 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 205918002435 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 205918002436 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 205918002437 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 205918002438 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 205918002439 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 205918002440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 205918002441 Uncharacterized conserved protein [Function unknown]; Region: COG2308 205918002442 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 205918002443 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 205918002444 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 205918002445 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 205918002446 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 205918002447 putative transposase OrfB; Reviewed; Region: PHA02517 205918002448 HTH-like domain; Region: HTH_21; pfam13276 205918002449 Integrase core domain; Region: rve; cl01316 205918002450 Integrase core domain; Region: rve_3; cl15866 205918002451 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918002452 Helix-turn-helix domains; Region: HTH; cl00088 205918002453 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 205918002454 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 205918002455 homodimer interface [polypeptide binding]; other site 205918002456 NAD binding pocket [chemical binding]; other site 205918002457 ATP binding pocket [chemical binding]; other site 205918002458 Mg binding site [ion binding]; other site 205918002459 active-site loop [active] 205918002460 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 205918002461 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 205918002462 active site 205918002463 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918002464 Helix-turn-helix domains; Region: HTH; cl00088 205918002465 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918002466 dimerization interface [polypeptide binding]; other site 205918002467 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 205918002468 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 205918002469 dimerization interface [polypeptide binding]; other site 205918002470 ligand binding site [chemical binding]; other site 205918002471 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 205918002472 TM-ABC transporter signature motif; other site 205918002473 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002474 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002475 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002476 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002477 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002478 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002479 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002480 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 205918002481 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 205918002482 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 205918002483 TM-ABC transporter signature motif; other site 205918002484 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002485 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002486 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002487 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002488 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002489 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002490 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002491 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002492 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002493 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002494 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918002495 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 205918002496 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 205918002497 Walker A/P-loop; other site 205918002498 ATP binding site [chemical binding]; other site 205918002499 Q-loop/lid; other site 205918002500 ABC transporter signature motif; other site 205918002501 Walker B; other site 205918002502 D-loop; other site 205918002503 H-loop/switch region; other site 205918002504 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 205918002505 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 205918002506 Walker A/P-loop; other site 205918002507 ATP binding site [chemical binding]; other site 205918002508 Q-loop/lid; other site 205918002509 ABC transporter signature motif; other site 205918002510 Walker B; other site 205918002511 D-loop; other site 205918002512 H-loop/switch region; other site 205918002513 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 205918002514 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 205918002515 putative NAD(P) binding site [chemical binding]; other site 205918002516 homotetramer interface [polypeptide binding]; other site 205918002517 homodimer interface [polypeptide binding]; other site 205918002518 active site 205918002519 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 205918002520 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 205918002521 dimerization interface [polypeptide binding]; other site 205918002522 putative active cleft [active] 205918002523 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 205918002524 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 205918002525 TPP-binding site; other site 205918002526 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 205918002527 PYR/PP interface [polypeptide binding]; other site 205918002528 dimer interface [polypeptide binding]; other site 205918002529 TPP binding site [chemical binding]; other site 205918002530 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 205918002531 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 205918002532 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 205918002533 substrate binding pocket [chemical binding]; other site 205918002534 chain length determination region; other site 205918002535 substrate-Mg2+ binding site; other site 205918002536 catalytic residues [active] 205918002537 aspartate-rich region 1; other site 205918002538 active site lid residues [active] 205918002539 aspartate-rich region 2; other site 205918002540 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 205918002541 cystathionine beta-lyase; Provisional; Region: PRK09028 205918002542 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205918002543 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918002544 catalytic residue [active] 205918002545 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 205918002546 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 205918002547 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 205918002548 putative S-transferase; Provisional; Region: PRK11752 205918002549 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 205918002550 C-terminal domain interface [polypeptide binding]; other site 205918002551 GSH binding site (G-site) [chemical binding]; other site 205918002552 dimer interface [polypeptide binding]; other site 205918002553 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 205918002554 dimer interface [polypeptide binding]; other site 205918002555 N-terminal domain interface [polypeptide binding]; other site 205918002556 active site 205918002557 ABC-2 type transporter; Region: ABC2_membrane; cl11417 205918002558 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002559 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002560 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002561 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002562 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002563 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002564 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918002565 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 205918002566 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 205918002567 Walker A/P-loop; other site 205918002568 ATP binding site [chemical binding]; other site 205918002569 Q-loop/lid; other site 205918002570 ABC transporter signature motif; other site 205918002571 Walker B; other site 205918002572 D-loop; other site 205918002573 H-loop/switch region; other site 205918002574 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 205918002575 Ligand binding site; other site 205918002576 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar2; cd08584 205918002577 putative active site [active] 205918002578 catalytic site [active] 205918002579 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 205918002580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918002581 motif II; other site 205918002582 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 205918002583 Ligand binding site; other site 205918002584 Cupin domain; Region: Cupin_2; cl09118 205918002585 WavE lipopolysaccharide synthesis; Region: WavE; pfam07507 205918002586 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 205918002587 1 probable transmembrane helix predicted by TMHMM2.0 205918002588 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918002589 non-specific DNA binding site [nucleotide binding]; other site 205918002590 salt bridge; other site 205918002591 sequence-specific DNA binding site [nucleotide binding]; other site 205918002592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918002593 non-specific DNA binding site [nucleotide binding]; other site 205918002594 salt bridge; other site 205918002595 sequence-specific DNA binding site [nucleotide binding]; other site 205918002596 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918002597 Catalytic site [active] 205918002598 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 205918002599 dimer interface [polypeptide binding]; other site 205918002600 substrate binding site [chemical binding]; other site 205918002601 metal binding sites [ion binding]; metal-binding site 205918002602 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 205918002603 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 205918002604 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 205918002605 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002606 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002607 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002608 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002609 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918002610 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 205918002611 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 205918002612 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 205918002613 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 205918002614 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918002615 NAD(P) binding site [chemical binding]; other site 205918002616 catalytic residues [active] 205918002617 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 205918002618 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 205918002619 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205918002620 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205918002621 aromatic acid decarboxylase; Validated; Region: PRK05920 205918002622 Flavoprotein; Region: Flavoprotein; cl08021 205918002623 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 205918002624 NAD binding site [chemical binding]; other site 205918002625 active site 205918002626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 205918002627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 205918002628 Peptidase C13 family; Region: Peptidase_C13; cl02159 205918002629 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 205918002630 putative active site [active] 205918002631 putative catalytic site [active] 205918002632 LrgA family; Region: LrgA; cl00608 205918002633 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002634 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002635 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002636 LrgB-like family; Region: LrgB; cl00596 205918002637 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002638 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002639 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002640 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002641 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002642 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002643 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 205918002644 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 205918002645 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 205918002646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918002647 S-adenosylmethionine binding site [chemical binding]; other site 205918002648 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 205918002649 homodimer interface [polypeptide binding]; other site 205918002650 chemical substrate binding site [chemical binding]; other site 205918002651 oligomer interface [polypeptide binding]; other site 205918002652 metal binding site [ion binding]; metal-binding site 205918002653 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 205918002654 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 205918002655 active site 2 [active] 205918002656 active site 1 [active] 205918002657 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 205918002658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918002659 NAD(P) binding site [chemical binding]; other site 205918002660 active site 205918002661 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 205918002662 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 205918002663 dimer interface [polypeptide binding]; other site 205918002664 active site 205918002665 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002666 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002667 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918002668 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 205918002669 Protein of unknown function (DUF726); Region: DUF726; pfam05277 205918002670 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 205918002671 Membrane transport protein; Region: Mem_trans; cl09117 205918002672 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002673 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002674 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002675 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002676 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002677 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002678 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002679 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002680 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002681 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002682 Cupin domain; Region: Cupin_2; cl09118 205918002683 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918002684 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 205918002685 ATP binding site [chemical binding]; other site 205918002686 Helix-turn-helix domains; Region: HTH; cl00088 205918002687 putative transposase OrfB; Reviewed; Region: PHA02517 205918002688 HTH-like domain; Region: HTH_21; pfam13276 205918002689 Integrase core domain; Region: rve; cl01316 205918002690 Integrase core domain; Region: rve_3; cl15866 205918002691 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 205918002692 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 205918002693 DNA binding residues [nucleotide binding] 205918002694 dimer interface [polypeptide binding]; other site 205918002695 copper binding site [ion binding]; other site 205918002696 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 205918002697 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 205918002698 metal-binding site [ion binding] 205918002699 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205918002700 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918002701 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002702 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002703 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002704 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002705 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002706 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002707 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002708 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918002709 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 205918002710 metal-binding site [ion binding] 205918002711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918002712 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 205918002713 putative substrate translocation pore; other site 205918002714 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002715 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002716 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002717 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002718 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002719 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002720 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002721 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002722 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002723 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002724 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002725 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002726 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 205918002727 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 205918002728 putative NAD(P) binding site [chemical binding]; other site 205918002729 dimer interface [polypeptide binding]; other site 205918002730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918002731 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918002732 putative effector binding pocket; other site 205918002733 dimerization interface [polypeptide binding]; other site 205918002734 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918002735 putative DNA binding site [nucleotide binding]; other site 205918002736 putative Zn2+ binding site [ion binding]; other site 205918002737 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 205918002738 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 205918002739 active site 205918002740 purine riboside binding site [chemical binding]; other site 205918002741 oxidase reductase; Provisional; Region: PTZ00273 205918002742 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 205918002743 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 205918002744 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 205918002745 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 205918002746 putative ligand binding site [chemical binding]; other site 205918002747 1 probable transmembrane helix predicted by TMHMM2.0 205918002748 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 205918002749 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 205918002750 Walker A/P-loop; other site 205918002751 ATP binding site [chemical binding]; other site 205918002752 Q-loop/lid; other site 205918002753 ABC transporter signature motif; other site 205918002754 Walker B; other site 205918002755 D-loop; other site 205918002756 H-loop/switch region; other site 205918002757 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918002758 ABC-ATPase subunit interface; other site 205918002759 dimer interface [polypeptide binding]; other site 205918002760 putative PBP binding regions; other site 205918002761 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002762 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002763 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002764 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002765 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002766 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002767 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002768 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002769 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002770 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 205918002771 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918002772 putative PBP binding regions; other site 205918002773 ABC-ATPase subunit interface; other site 205918002774 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002775 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002776 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002777 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002778 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002779 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002780 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002781 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002782 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002783 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 205918002784 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 205918002785 siderophore binding site; other site 205918002786 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 205918002787 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 205918002788 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002789 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002790 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002791 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002792 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002793 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002794 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002795 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002796 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002797 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 205918002798 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 205918002799 active site 205918002800 putative substrate binding pocket [chemical binding]; other site 205918002801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918002802 NAD(P) binding site [chemical binding]; other site 205918002803 active site 205918002804 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 205918002805 TM-ABC transporter signature motif; other site 205918002806 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002807 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002808 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002809 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002810 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002811 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002812 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002813 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002814 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002815 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 205918002816 TM-ABC transporter signature motif; other site 205918002817 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002818 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002819 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002820 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002821 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002822 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002823 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002824 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002825 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918002826 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 205918002827 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 205918002828 Walker A/P-loop; other site 205918002829 ATP binding site [chemical binding]; other site 205918002830 Q-loop/lid; other site 205918002831 ABC transporter signature motif; other site 205918002832 Walker B; other site 205918002833 D-loop; other site 205918002834 H-loop/switch region; other site 205918002835 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 205918002836 Uncharacterized conserved protein [Function unknown]; Region: COG1739 205918002837 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 205918002838 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 205918002839 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 205918002840 Helix-turn-helix domains; Region: HTH; cl00088 205918002841 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 205918002842 xanthine permease; Region: pbuX; TIGR03173 205918002843 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 205918002844 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002845 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002846 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002847 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002848 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002849 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002850 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002851 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002852 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002853 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002854 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002855 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918002856 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918002857 Helix-turn-helix domains; Region: HTH; cl00088 205918002858 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918002859 dimerization interface [polypeptide binding]; other site 205918002860 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 205918002861 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918002862 inhibitor-cofactor binding pocket; inhibition site 205918002863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918002864 catalytic residue [active] 205918002865 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 205918002866 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918002867 tetrameric interface [polypeptide binding]; other site 205918002868 NAD binding site [chemical binding]; other site 205918002869 catalytic residues [active] 205918002870 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 205918002871 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 205918002872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918002873 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 205918002874 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 205918002875 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 205918002876 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918002877 Family description; Region: UvrD_C_2; cl15862 205918002878 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 205918002879 nudix motif; other site 205918002880 1 probable transmembrane helix predicted by TMHMM2.0 205918002881 PAAR motif; Region: PAAR_motif; cl15808 205918002882 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918002883 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918002884 GAD-like domain; Region: GAD-like; pfam08887 205918002885 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 205918002886 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918002887 Helix-turn-helix domains; Region: HTH; cl00088 205918002888 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918002889 dimerization interface [polypeptide binding]; other site 205918002890 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 205918002891 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918002892 tetrameric interface [polypeptide binding]; other site 205918002893 NAD binding site [chemical binding]; other site 205918002894 catalytic residues [active] 205918002895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918002896 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 205918002897 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 205918002898 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 205918002899 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 205918002900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 205918002901 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002902 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002903 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002904 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002905 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002906 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 205918002908 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002909 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002910 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002911 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002912 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002913 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918002914 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 205918002915 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918002916 Walker A/P-loop; other site 205918002917 ATP binding site [chemical binding]; other site 205918002918 Q-loop/lid; other site 205918002919 ABC transporter signature motif; other site 205918002920 Walker B; other site 205918002921 D-loop; other site 205918002922 H-loop/switch region; other site 205918002923 NMT1-like family; Region: NMT1_2; cl15260 205918002924 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 205918002925 selenophosphate synthetase; Provisional; Region: PRK00943 205918002926 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 205918002927 dimerization interface [polypeptide binding]; other site 205918002928 putative ATP binding site [chemical binding]; other site 205918002929 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 205918002930 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 205918002931 active site residue [active] 205918002932 membrane protein 205918002933 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918002934 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918002935 membrane protein 205918002936 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 205918002937 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 205918002938 substrate binding pocket [chemical binding]; other site 205918002939 chain length determination region; other site 205918002940 substrate-Mg2+ binding site; other site 205918002941 catalytic residues [active] 205918002942 aspartate-rich region 1; other site 205918002943 active site lid residues [active] 205918002944 aspartate-rich region 2; other site 205918002945 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 205918002946 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 205918002947 GTPase CgtA; Reviewed; Region: obgE; PRK12298 205918002948 GTP1/OBG; Region: GTP1_OBG; pfam01018 205918002949 Obg GTPase; Region: Obg; cd01898 205918002950 G1 box; other site 205918002951 GTP/Mg2+ binding site [chemical binding]; other site 205918002952 Switch I region; other site 205918002953 G2 box; other site 205918002954 G3 box; other site 205918002955 Switch II region; other site 205918002956 G4 box; other site 205918002957 G5 box; other site 205918002958 gamma-glutamyl kinase; Provisional; Region: PRK05429 205918002959 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 205918002960 nucleotide binding site [chemical binding]; other site 205918002961 homotetrameric interface [polypeptide binding]; other site 205918002962 putative phosphate binding site [ion binding]; other site 205918002963 putative allosteric binding site; other site 205918002964 PUA domain; Region: PUA; cl00607 205918002965 CreA protein; Region: CreA; pfam05981 205918002966 OpgC protein; Region: OpgC_C; cl00792 205918002967 Acyltransferase family; Region: Acyl_transf_3; pfam01757 205918002968 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002969 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002970 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002971 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002972 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002973 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002974 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002975 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002976 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002977 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918002978 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 205918002979 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 205918002980 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918002981 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918002982 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918002983 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918002984 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918002985 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918002986 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918002987 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918002988 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918002989 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918002990 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918002991 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918002992 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918002993 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 205918002994 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 205918002995 active site 205918002996 Riboflavin kinase; Region: Flavokinase; cl03312 205918002997 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 205918002998 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205918002999 active site 205918003000 HIGH motif; other site 205918003001 nucleotide binding site [chemical binding]; other site 205918003002 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 205918003003 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 205918003004 active site 205918003005 KMSKS motif; other site 205918003006 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 205918003007 tRNA binding surface [nucleotide binding]; other site 205918003008 anticodon binding site; other site 205918003009 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 205918003010 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 205918003011 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003012 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003013 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003014 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003015 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003016 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 205918003017 LytB protein; Region: LYTB; cl00507 205918003018 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 205918003019 Type II transport protein GspH; Region: GspH; pfam12019 205918003020 1 probable transmembrane helix predicted by TMHMM2.0 205918003021 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 205918003022 Type II transport protein GspH; Region: GspH; pfam12019 205918003023 1 probable transmembrane helix predicted by TMHMM2.0 205918003024 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 205918003025 1 probable transmembrane helix predicted by TMHMM2.0 205918003026 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 205918003027 1 probable transmembrane helix predicted by TMHMM2.0 205918003028 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 205918003029 PilX N-terminal; Region: PilX_N; pfam14341 205918003030 1 probable transmembrane helix predicted by TMHMM2.0 205918003031 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 205918003032 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 205918003033 1 probable transmembrane helix predicted by TMHMM2.0 205918003034 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 205918003035 1 probable transmembrane helix predicted by TMHMM2.0 205918003036 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 205918003037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918003038 1 probable transmembrane helix predicted by TMHMM2.0 205918003039 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918003040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918003041 active site 205918003042 phosphorylation site [posttranslational modification] 205918003043 intermolecular recognition site; other site 205918003044 dimerization interface [polypeptide binding]; other site 205918003045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918003046 Walker A motif; other site 205918003047 ATP binding site [chemical binding]; other site 205918003048 Walker B motif; other site 205918003049 arginine finger; other site 205918003050 Helix-turn-helix domains; Region: HTH; cl00088 205918003051 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 205918003052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918003053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918003054 dimer interface [polypeptide binding]; other site 205918003055 phosphorylation site [posttranslational modification] 205918003056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918003057 ATP binding site [chemical binding]; other site 205918003058 Mg2+ binding site [ion binding]; other site 205918003059 G-X-G motif; other site 205918003060 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003061 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003062 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003063 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003064 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003065 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 205918003066 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 205918003067 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205918003068 RNA binding surface [nucleotide binding]; other site 205918003069 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 205918003070 active site 205918003071 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 205918003072 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 205918003073 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 205918003074 Clp amino terminal domain; Region: Clp_N; pfam02861 205918003075 Clp amino terminal domain; Region: Clp_N; pfam02861 205918003076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918003077 Walker A motif; other site 205918003078 ATP binding site [chemical binding]; other site 205918003079 Walker B motif; other site 205918003080 arginine finger; other site 205918003081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918003082 Walker A motif; other site 205918003083 ATP binding site [chemical binding]; other site 205918003084 Walker B motif; other site 205918003085 arginine finger; other site 205918003086 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 205918003087 Integrase 205918003088 Integrase 205918003089 Protein of unknown function DUF1528 205918003090 conserved hypothetical protein 205918003091 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 205918003092 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 205918003093 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918003094 Catalytic site [active] 205918003095 Y-family of DNA polymerases; Region: PolY; cl12025 205918003096 active site 205918003097 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 205918003098 Phage integrase, N-terminal SAM-like 205918003099 Phage integrase 205918003100 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918003101 Helix-turn-helix domains; Region: HTH; cl00088 205918003102 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 205918003103 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918003104 substrate binding site [chemical binding]; other site 205918003105 oxyanion hole (OAH) forming residues; other site 205918003106 trimer interface [polypeptide binding]; other site 205918003107 hypothetical protein 205918003108 Transposase IS66 205918003109 hypothetical protein 205918003110 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 205918003111 Transposase IS3/IS911 205918003112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918003113 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205918003114 putative substrate translocation pore; other site 205918003115 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003116 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003117 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003118 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003119 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003120 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003121 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003122 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003123 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003124 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003125 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003126 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003127 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003128 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003129 acyl-CoA synthetase; Validated; Region: PRK06188 205918003130 AMP-binding enzyme; Region: AMP-binding; cl15778 205918003131 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918003132 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 205918003133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918003134 DDE superfamily endonuclease; Region: DDE_4; cl15789 205918003135 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 205918003136 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 205918003137 active site 205918003138 MEKHLA domain; Region: MEKHLA; pfam08670 205918003139 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 205918003140 active site 205918003141 ribulose/triose binding site [chemical binding]; other site 205918003142 phosphate binding site [ion binding]; other site 205918003143 substrate (anthranilate) binding pocket [chemical binding]; other site 205918003144 product (indole) binding pocket [chemical binding]; other site 205918003145 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205918003146 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205918003147 DNA binding site [nucleotide binding] 205918003148 domain linker motif; other site 205918003149 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 205918003150 putative dimerization interface [polypeptide binding]; other site 205918003151 putative ligand binding site [chemical binding]; other site 205918003152 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 205918003153 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 205918003154 substrate binding [chemical binding]; other site 205918003155 active site 205918003156 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 205918003157 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 205918003158 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 205918003159 Walker A/P-loop; other site 205918003160 ATP binding site [chemical binding]; other site 205918003161 Q-loop/lid; other site 205918003162 ABC transporter signature motif; other site 205918003163 Walker B; other site 205918003164 D-loop; other site 205918003165 H-loop/switch region; other site 205918003166 TOBE domain; Region: TOBE_2; cl01440 205918003167 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205918003168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918003169 dimer interface [polypeptide binding]; other site 205918003170 conserved gate region; other site 205918003171 putative PBP binding loops; other site 205918003172 ABC-ATPase subunit interface; other site 205918003173 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003174 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003175 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003176 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003177 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003178 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003179 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 205918003180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918003181 dimer interface [polypeptide binding]; other site 205918003182 conserved gate region; other site 205918003183 putative PBP binding loops; other site 205918003184 ABC-ATPase subunit interface; other site 205918003185 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003186 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003187 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003188 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003189 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003190 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003191 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205918003192 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918003193 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 205918003194 trimer interface; other site 205918003195 sugar binding site [chemical binding]; other site 205918003196 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 205918003197 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 205918003198 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003199 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003200 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003201 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 205918003202 Helix-turn-helix domains; Region: HTH; cl00088 205918003203 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 205918003204 dimerization interface [polypeptide binding]; other site 205918003205 substrate binding pocket [chemical binding]; other site 205918003206 Protein of unknown function (DUF421); Region: DUF421; cl00990 205918003207 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003208 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003209 1 probable transmembrane helix predicted by TMHMM2.0 205918003210 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 205918003211 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 205918003212 metal binding site [ion binding]; metal-binding site 205918003213 dimer interface [polypeptide binding]; other site 205918003214 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 205918003215 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 205918003216 active site 205918003217 substrate binding pocket [chemical binding]; other site 205918003218 homodimer interaction site [polypeptide binding]; other site 205918003219 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918003220 TM-ABC transporter signature motif; other site 205918003221 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003222 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003223 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003224 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003225 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003226 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003227 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003228 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003229 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003230 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 205918003231 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 205918003232 Walker A/P-loop; other site 205918003233 ATP binding site [chemical binding]; other site 205918003234 Q-loop/lid; other site 205918003235 ABC transporter signature motif; other site 205918003236 Walker B; other site 205918003237 D-loop; other site 205918003238 H-loop/switch region; other site 205918003239 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 205918003240 ligand binding site [chemical binding]; other site 205918003241 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205918003242 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205918003243 DNA binding site [nucleotide binding] 205918003244 domain linker motif; other site 205918003245 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 205918003246 putative dimerization interface [polypeptide binding]; other site 205918003247 putative ligand binding site [chemical binding]; other site 205918003248 HipA-like N-terminal domain; Region: HipA_N; pfam07805 205918003249 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 205918003250 nudix motif; other site 205918003251 similar to Pseudomonas syringae tomato virulence protein HopAI1; this region is disrupted by a frameshift between 887086 and 887089 205918003252 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 205918003253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918003254 active site 205918003255 phosphorylation site [posttranslational modification] 205918003256 intermolecular recognition site; other site 205918003257 dimerization interface [polypeptide binding]; other site 205918003258 CheB methylesterase; Region: CheB_methylest; pfam01339 205918003259 CheD chemotactic sensory transduction; Region: CheD; cl00810 205918003260 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 205918003261 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 205918003262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918003263 S-adenosylmethionine binding site [chemical binding]; other site 205918003264 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 205918003265 putative CheA interaction surface; other site 205918003266 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918003267 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918003268 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918003269 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003270 dimer interface [polypeptide binding]; other site 205918003271 putative CheW interface [polypeptide binding]; other site 205918003272 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003273 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003274 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 205918003275 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918003276 putative binding surface; other site 205918003277 active site 205918003278 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 205918003279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918003280 ATP binding site [chemical binding]; other site 205918003281 Mg2+ binding site [ion binding]; other site 205918003282 G-X-G motif; other site 205918003283 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 205918003284 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 205918003285 anti sigma factor interaction site; other site 205918003286 regulatory phosphorylation site [posttranslational modification]; other site 205918003287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918003288 active site 205918003289 phosphorylation site [posttranslational modification] 205918003290 intermolecular recognition site; other site 205918003291 dimerization interface [polypeptide binding]; other site 205918003292 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003293 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003294 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 205918003295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918003296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918003297 MOSC domain; Region: MOSC; pfam03473 205918003298 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 205918003299 Domain of unknown function (DUF329); Region: DUF329; cl01144 205918003300 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 205918003301 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 205918003302 CoA-binding site [chemical binding]; other site 205918003303 ATP-binding [chemical binding]; other site 205918003304 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 205918003305 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 205918003306 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 205918003307 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003308 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003309 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003310 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003311 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003312 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003313 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 205918003314 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 205918003315 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 205918003316 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003317 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003318 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003319 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 205918003320 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 205918003321 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 205918003322 Walker A motif; other site 205918003323 ATP binding site [chemical binding]; other site 205918003324 Walker B motif; other site 205918003325 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 205918003326 Pilin (bacterial filament); Region: Pilin; pfam00114 205918003327 1 probable transmembrane helix predicted by TMHMM2.0 205918003328 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 205918003329 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003330 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003331 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918003332 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 205918003333 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 205918003334 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918003335 active site 205918003336 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 205918003337 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 205918003338 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 205918003339 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 205918003340 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918003341 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 205918003342 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 205918003343 putative metal binding site [ion binding]; other site 205918003344 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 205918003345 putative metal binding site [ion binding]; other site 205918003346 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 205918003347 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 205918003348 putative metal binding site [ion binding]; other site 205918003349 tellurite resistance protein terB; Region: terB; cd07176 205918003350 putative metal binding site [ion binding]; other site 205918003351 Integral membrane protein TerC family; Region: TerC; cl10468 205918003352 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003353 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003354 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003355 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003356 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003357 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003358 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003359 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003360 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003361 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 205918003362 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 205918003363 putative metal binding site [ion binding]; other site 205918003364 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 205918003365 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 205918003366 putative metal binding site [ion binding]; other site 205918003367 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 205918003368 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 205918003369 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 205918003370 dimerization interface [polypeptide binding]; other site 205918003371 active site 205918003372 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 205918003373 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 205918003374 amidase catalytic site [active] 205918003375 Zn binding residues [ion binding]; other site 205918003376 substrate binding site [chemical binding]; other site 205918003377 CobD/Cbib protein; Region: CobD_Cbib; cl00561 205918003378 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003379 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003380 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003381 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003382 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003383 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 205918003384 active site 205918003385 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 205918003386 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205918003387 DNA binding site [nucleotide binding] 205918003388 domain linker motif; other site 205918003389 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 205918003390 dimerization interface [polypeptide binding]; other site 205918003391 ligand binding site [chemical binding]; other site 205918003392 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 205918003393 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 205918003394 active site 205918003395 phosphorylation site [posttranslational modification] 205918003396 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 205918003397 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 205918003398 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 205918003399 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 205918003400 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 205918003401 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 205918003402 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 205918003403 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 205918003404 putative substrate binding site [chemical binding]; other site 205918003405 putative ATP binding site [chemical binding]; other site 205918003406 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 205918003407 active site 205918003408 P-loop; other site 205918003409 phosphorylation site [posttranslational modification] 205918003410 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 205918003411 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 205918003412 active site 205918003413 P-loop; other site 205918003414 phosphorylation site [posttranslational modification] 205918003415 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 205918003416 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003417 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003418 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003419 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003420 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003421 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003422 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003423 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003424 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918003425 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 205918003426 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 205918003427 dimer interface [polypeptide binding]; other site 205918003428 active site 205918003429 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 205918003430 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 205918003431 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 205918003432 active site 205918003433 dimer interface [polypeptide binding]; other site 205918003434 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 205918003435 dimer interface [polypeptide binding]; other site 205918003436 active site 205918003437 Pantoate-beta-alanine ligase; Region: PanC; cd00560 205918003438 pantoate--beta-alanine ligase; Region: panC; TIGR00018 205918003439 active site 205918003440 ATP-binding site [chemical binding]; other site 205918003441 pantoate-binding site; other site 205918003442 HXXH motif; other site 205918003443 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 205918003444 oligomerization interface [polypeptide binding]; other site 205918003445 active site 205918003446 metal binding site [ion binding]; metal-binding site 205918003447 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 205918003448 catalytic center binding site [active] 205918003449 ATP binding site [chemical binding]; other site 205918003450 poly(A) polymerase; Region: pcnB; TIGR01942 205918003451 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 205918003452 active site 205918003453 NTP binding site [chemical binding]; other site 205918003454 metal binding triad [ion binding]; metal-binding site 205918003455 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 205918003456 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 205918003457 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918003458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918003459 active site 205918003460 phosphorylation site [posttranslational modification] 205918003461 intermolecular recognition site; other site 205918003462 dimerization interface [polypeptide binding]; other site 205918003463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918003464 Walker A motif; other site 205918003465 ATP binding site [chemical binding]; other site 205918003466 Walker B motif; other site 205918003467 arginine finger; other site 205918003468 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 205918003469 Na binding site [ion binding]; other site 205918003470 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 205918003471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918003472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918003473 dimer interface [polypeptide binding]; other site 205918003474 phosphorylation site [posttranslational modification] 205918003475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918003476 ATP binding site [chemical binding]; other site 205918003477 Mg2+ binding site [ion binding]; other site 205918003478 G-X-G motif; other site 205918003479 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003480 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003481 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003482 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003483 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003484 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003485 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003486 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003487 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003488 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003489 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003490 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003491 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003492 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918003493 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003494 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003495 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205918003496 active site 205918003497 HIGH motif; other site 205918003498 nucleotide binding site [chemical binding]; other site 205918003499 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205918003500 KMSKS motif; other site 205918003501 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 205918003502 aminotransferase; Validated; Region: PRK07337 205918003503 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918003504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918003505 homodimer interface [polypeptide binding]; other site 205918003506 catalytic residue [active] 205918003507 Sugar fermentation stimulation protein; Region: SfsA; cl00647 205918003508 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 205918003509 iron-sulfur cluster [ion binding]; other site 205918003510 [2Fe-2S] cluster binding site [ion binding]; other site 205918003511 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 205918003512 intersubunit interface [polypeptide binding]; other site 205918003513 active site 205918003514 catalytic residue [active] 205918003515 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 205918003516 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 205918003517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 205918003518 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 205918003519 AAA domain; Region: AAA_33; pfam13671 205918003520 ATP-binding site [chemical binding]; other site 205918003521 Gluconate-6-phosphate binding site [chemical binding]; other site 205918003522 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 205918003523 Transglycosylase; Region: Transgly; cl07896 205918003524 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918003525 1 probable transmembrane helix predicted by TMHMM2.0 205918003526 Tetratricopeptide repeat; Region: TPR_16; pfam13432 205918003527 tRNA pseudouridine synthase C; Region: DUF446; cl01187 205918003528 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 205918003529 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 205918003530 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 205918003531 PYR/PP interface [polypeptide binding]; other site 205918003532 dimer interface [polypeptide binding]; other site 205918003533 TPP binding site [chemical binding]; other site 205918003534 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 205918003535 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 205918003536 TPP-binding site [chemical binding]; other site 205918003537 dimer interface [polypeptide binding]; other site 205918003538 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 205918003539 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 205918003540 putative valine binding site [chemical binding]; other site 205918003541 dimer interface [polypeptide binding]; other site 205918003542 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 205918003543 ketol-acid reductoisomerase; Provisional; Region: PRK05479 205918003544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918003545 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 205918003546 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 205918003547 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 205918003548 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003549 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003550 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003551 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003552 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003553 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003554 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003555 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918003556 TMAO/DMSO reductase; Reviewed; Region: PRK05363 205918003557 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 205918003558 Moco binding site; other site 205918003559 metal coordination site [ion binding]; other site 205918003560 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 205918003561 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003562 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003563 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003564 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003565 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003566 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003567 Right handed beta helix region; Region: Beta_helix; pfam13229 205918003568 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 205918003569 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 205918003570 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918003571 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 205918003572 active site clefts [active] 205918003573 zinc binding site [ion binding]; other site 205918003574 dimer interface [polypeptide binding]; other site 205918003575 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918003576 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918003577 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918003578 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003579 dimer interface [polypeptide binding]; other site 205918003580 putative CheW interface [polypeptide binding]; other site 205918003581 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003582 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003583 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205918003584 OpgC protein; Region: OpgC_C; cl00792 205918003585 Acyltransferase family; Region: Acyl_transf_3; pfam01757 205918003586 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003587 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003588 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003589 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003590 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003591 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003592 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003593 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003594 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003595 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003596 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 205918003597 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 205918003598 PhnA protein; Region: PhnA; pfam03831 205918003599 Protein of unknown function, DUF393; Region: DUF393; cl01136 205918003600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918003601 putative substrate translocation pore; other site 205918003602 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003603 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003604 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003605 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003606 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003607 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003608 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003609 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003610 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003611 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003612 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003613 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918003614 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 205918003615 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 205918003616 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003617 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003618 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003619 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003620 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003621 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003622 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205918003623 metal binding site [ion binding]; metal-binding site 205918003624 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 205918003625 putative active site [active] 205918003626 putative metal binding site [ion binding]; other site 205918003627 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918003628 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 205918003629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918003630 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918003631 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003632 dimer interface [polypeptide binding]; other site 205918003633 putative CheW interface [polypeptide binding]; other site 205918003634 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003635 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918003637 Coenzyme A binding pocket [chemical binding]; other site 205918003638 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918003639 metal binding site [ion binding]; metal-binding site 205918003640 active site 205918003641 I-site; other site 205918003642 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003643 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003644 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003645 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003646 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003647 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003648 PAS domain; Region: PAS_9; pfam13426 205918003649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918003650 putative active site [active] 205918003651 heme pocket [chemical binding]; other site 205918003652 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918003653 PAS domain; Region: PAS_9; pfam13426 205918003654 putative active site [active] 205918003655 heme pocket [chemical binding]; other site 205918003656 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003657 dimer interface [polypeptide binding]; other site 205918003658 putative CheW interface [polypeptide binding]; other site 205918003659 PhoD-like phosphatase; Region: PhoD; pfam09423 205918003660 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 205918003661 putative active site [active] 205918003662 putative metal binding site [ion binding]; other site 205918003663 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205918003664 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205918003665 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918003666 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 205918003667 1 probable transmembrane helix predicted by TMHMM2.0 205918003668 Gram-negative bacterial tonB protein; Region: TonB; cl10048 205918003669 1 probable transmembrane helix predicted by TMHMM2.0 205918003670 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918003671 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918003672 N-terminal plug; other site 205918003673 ligand-binding site [chemical binding]; other site 205918003674 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 205918003675 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003676 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003677 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918003678 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 205918003679 PLD-like domain; Region: PLDc_2; pfam13091 205918003680 putative active site [active] 205918003681 putative catalytic site [active] 205918003682 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 205918003683 putative active site [active] 205918003684 putative catalytic site [active] 205918003685 putative acetyltransferase YhhY; Provisional; Region: PRK10140 205918003686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918003687 Coenzyme A binding pocket [chemical binding]; other site 205918003688 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918003689 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 205918003690 MltA specific insert domain; Region: MltA; cl08398 205918003691 3D domain; Region: 3D; cl01439 205918003692 S-type Pyocin; Region: Pyocin_S; pfam06958 205918003693 RES domain; Region: RES; cl02411 205918003694 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 205918003695 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 205918003696 Response regulator receiver domain; Region: Response_reg; pfam00072 205918003697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918003698 active site 205918003699 phosphorylation site [posttranslational modification] 205918003700 intermolecular recognition site; other site 205918003701 dimerization interface [polypeptide binding]; other site 205918003702 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 205918003703 PAS fold; Region: PAS_4; pfam08448 205918003704 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 205918003705 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 205918003706 hinge; other site 205918003707 active site 205918003708 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 205918003709 PemK-like protein; Region: PemK; cl00995 205918003710 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 205918003711 Cupin domain; Region: Cupin_2; cl09118 205918003712 1 probable transmembrane helix predicted by TMHMM2.0 205918003713 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 205918003714 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918003715 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918003716 DNA binding residues [nucleotide binding] 205918003717 1 probable transmembrane helix predicted by TMHMM2.0 205918003718 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 205918003719 oligomeric interface; other site 205918003720 putative active site [active] 205918003721 homodimer interface [polypeptide binding]; other site 205918003722 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 205918003723 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 205918003724 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 205918003725 active site 205918003726 catalytic residues [active] 205918003727 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 205918003728 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003729 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003730 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003731 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003732 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003733 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003734 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003735 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003736 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003737 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003738 DctM-like transporters; Region: DctM; pfam06808 205918003739 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 205918003740 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003741 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003742 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003743 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003744 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003745 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003746 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003747 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003748 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003749 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003750 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003751 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 205918003752 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003753 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003754 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003755 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003756 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 205918003757 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 205918003758 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 205918003759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918003760 extended (e) SDRs; Region: SDR_e; cd08946 205918003761 NAD(P) binding site [chemical binding]; other site 205918003762 active site 205918003763 active site 205918003764 substrate binding site [chemical binding]; other site 205918003765 outer membrane porin, OprD family; Region: OprD; pfam03573 205918003766 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 205918003767 classical (c) SDRs; Region: SDR_c; cd05233 205918003768 NAD(P) binding site [chemical binding]; other site 205918003769 active site 205918003770 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918003771 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918003772 dimerization interface [polypeptide binding]; other site 205918003773 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003774 dimer interface [polypeptide binding]; other site 205918003775 putative CheW interface [polypeptide binding]; other site 205918003776 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003777 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003778 Cache domain; Region: Cache_1; pfam02743 205918003779 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918003780 dimerization interface [polypeptide binding]; other site 205918003781 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918003782 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003783 dimer interface [polypeptide binding]; other site 205918003784 putative CheW interface [polypeptide binding]; other site 205918003785 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003786 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003787 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 205918003788 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 205918003789 active site 205918003790 substrate binding site [chemical binding]; other site 205918003791 FMN binding site [chemical binding]; other site 205918003792 putative catalytic residues [active] 205918003793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918003794 Helix-turn-helix domains; Region: HTH; cl00088 205918003795 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 205918003796 putative dimerization interface [polypeptide binding]; other site 205918003797 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918003798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918003799 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 205918003800 EamA-like transporter family; Region: EamA; cl01037 205918003801 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003802 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003803 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003804 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003805 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003806 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003807 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003808 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003809 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003810 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918003811 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 205918003812 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918003813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918003814 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918003815 dimer interface [polypeptide binding]; other site 205918003816 putative CheW interface [polypeptide binding]; other site 205918003817 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003818 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918003819 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918003820 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 205918003821 putative ADP-binding pocket [chemical binding]; other site 205918003822 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 205918003823 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 205918003824 NADP-binding site; other site 205918003825 homotetramer interface [polypeptide binding]; other site 205918003826 substrate binding site [chemical binding]; other site 205918003827 homodimer interface [polypeptide binding]; other site 205918003828 active site 205918003829 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 205918003830 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 205918003831 NADP-binding site; other site 205918003832 homotetramer interface [polypeptide binding]; other site 205918003833 substrate binding site [chemical binding]; other site 205918003834 homodimer interface [polypeptide binding]; other site 205918003835 active site 205918003836 ABC-2 type transporter; Region: ABC2_membrane; cl11417 205918003837 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003838 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003839 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003840 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003841 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003842 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918003843 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 205918003844 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 205918003845 Walker A/P-loop; other site 205918003846 ATP binding site [chemical binding]; other site 205918003847 Q-loop/lid; other site 205918003848 ABC transporter signature motif; other site 205918003849 Walker B; other site 205918003850 D-loop; other site 205918003851 H-loop/switch region; other site 205918003852 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 205918003853 putative carbohydrate binding site [chemical binding]; other site 205918003854 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 205918003855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918003856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918003857 S-adenosylmethionine binding site [chemical binding]; other site 205918003858 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205918003859 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 205918003860 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918003861 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 205918003862 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918003863 GtrA-like protein; Region: GtrA; cl00971 205918003864 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003865 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003866 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003867 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918003868 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 205918003869 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 205918003870 Ligand binding site; other site 205918003871 Putative Catalytic site; other site 205918003872 DXD motif; other site 205918003873 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003874 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003875 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003876 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003877 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003878 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003879 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003880 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003881 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003882 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003883 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918003884 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 205918003885 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 205918003886 substrate binding site; other site 205918003887 tetramer interface; other site 205918003888 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 205918003889 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 205918003890 NADP binding site [chemical binding]; other site 205918003891 active site 205918003892 putative substrate binding site [chemical binding]; other site 205918003893 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 205918003894 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 205918003895 NAD binding site [chemical binding]; other site 205918003896 substrate binding site [chemical binding]; other site 205918003897 homodimer interface [polypeptide binding]; other site 205918003898 active site 205918003899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918003900 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 205918003901 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918003902 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 205918003903 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 205918003904 Probable Catalytic site; other site 205918003905 metal-binding site 205918003906 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 205918003907 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918003908 active site 205918003909 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 205918003910 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 205918003911 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 205918003912 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 205918003913 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205918003914 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 205918003915 Walker A/P-loop; other site 205918003916 ATP binding site [chemical binding]; other site 205918003917 Q-loop/lid; other site 205918003918 ABC transporter signature motif; other site 205918003919 Walker B; other site 205918003920 D-loop; other site 205918003921 H-loop/switch region; other site 205918003922 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003923 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003924 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003925 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003926 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918003927 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 205918003928 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918003929 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918003930 1 probable transmembrane helix predicted by TMHMM2.0 205918003931 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 205918003932 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 205918003933 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 205918003934 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 205918003935 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 205918003936 Substrate binding site; other site 205918003937 Cupin domain; Region: Cupin_2; cl09118 205918003938 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 205918003939 Transcriptional regulator, AcrR family 205918003940 transcriptional regulatory protein 205918003941 GTP-binding protein YchF; Reviewed; Region: PRK09601 205918003942 YchF GTPase; Region: YchF; cd01900 205918003943 G1 box; other site 205918003944 GTP/Mg2+ binding site [chemical binding]; other site 205918003945 Switch I region; other site 205918003946 G2 box; other site 205918003947 Switch II region; other site 205918003948 G3 box; other site 205918003949 G4 box; other site 205918003950 G5 box; other site 205918003951 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 205918003952 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 205918003953 putative active site [active] 205918003954 catalytic residue [active] 205918003955 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 205918003956 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 205918003957 5S rRNA interface [nucleotide binding]; other site 205918003958 CTC domain interface [polypeptide binding]; other site 205918003959 L16 interface [polypeptide binding]; other site 205918003960 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 205918003961 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 205918003962 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918003963 active site 205918003964 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 205918003965 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 205918003966 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 205918003967 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 205918003968 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 205918003969 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 205918003970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918003971 TPR motif; other site 205918003972 binding surface 205918003973 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 205918003974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918003975 binding surface 205918003976 TPR motif; other site 205918003977 TPR repeat; Region: TPR_11; pfam13414 205918003978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918003979 binding surface 205918003980 TPR motif; other site 205918003981 TPR repeat; Region: TPR_11; pfam13414 205918003982 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 205918003983 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 205918003984 tRNA; other site 205918003985 putative tRNA binding site [nucleotide binding]; other site 205918003986 putative NADP binding site [chemical binding]; other site 205918003987 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 205918003988 peptide chain release factor 1; Validated; Region: prfA; PRK00591 205918003989 RF-1 domain; Region: RF-1; cl02875 205918003990 RF-1 domain; Region: RF-1; cl02875 205918003991 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 205918003992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918003993 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 205918003994 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 205918003995 ATP binding site [chemical binding]; other site 205918003996 substrate interface [chemical binding]; other site 205918003997 1 probable transmembrane helix predicted by TMHMM2.0 205918003998 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 205918003999 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 205918004000 Flagellin N-methylase; Region: FliB; cl00497 205918004001 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 205918004002 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004003 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004004 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004005 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004006 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004007 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 205918004008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918004009 S-adenosylmethionine binding site [chemical binding]; other site 205918004010 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 205918004011 Uncharacterized conserved protein [Function unknown]; Region: COG3496 205918004012 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 205918004013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918004014 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 205918004015 classical (c) SDRs; Region: SDR_c; cd05233 205918004016 NAD(P) binding site [chemical binding]; other site 205918004017 active site 205918004018 1 probable transmembrane helix predicted by TMHMM2.0 205918004019 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 205918004020 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 205918004021 DNA photolyase; Region: DNA_photolyase; pfam00875 205918004022 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 205918004023 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 205918004024 DNA binding residues [nucleotide binding] 205918004025 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 205918004026 B12 binding domain; Region: B12-binding_2; cl03653 205918004027 Protein of unknown function (DUF523); Region: DUF523; cl00733 205918004028 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 205918004029 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 205918004030 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 205918004031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918004032 TIGR01777 family protein; Region: yfcH 205918004033 NAD(P) binding site [chemical binding]; other site 205918004034 active site 205918004035 ferrochelatase; Reviewed; Region: hemH; PRK00035 205918004036 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 205918004037 C-terminal domain interface [polypeptide binding]; other site 205918004038 active site 205918004039 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 205918004040 active site 205918004041 N-terminal domain interface [polypeptide binding]; other site 205918004042 uracil-xanthine permease; Region: ncs2; TIGR00801 205918004043 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004044 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004045 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004046 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004047 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004048 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004049 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004050 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004051 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004052 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004053 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004054 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004055 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918004056 active site 205918004057 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918004058 active site 205918004059 1 probable transmembrane helix predicted by TMHMM2.0 205918004060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 205918004061 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918004062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918004063 putative PBP binding loops; other site 205918004064 dimer interface [polypeptide binding]; other site 205918004065 ABC-ATPase subunit interface; other site 205918004066 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004067 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004068 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004069 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004070 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004071 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918004073 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918004074 substrate binding pocket [chemical binding]; other site 205918004075 membrane-bound complex binding site; other site 205918004076 hinge residues; other site 205918004077 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 205918004078 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 205918004079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918004080 Predicted dehydrogenase [General function prediction only]; Region: COG0579 205918004081 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918004082 putative acyl-acceptor binding pocket; other site 205918004083 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 205918004084 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 205918004085 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918004086 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 205918004087 Peptidase family M48; Region: Peptidase_M48; cl12018 205918004088 1 probable transmembrane helix predicted by TMHMM2.0 205918004089 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 205918004090 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 205918004091 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004092 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004093 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004094 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004095 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004096 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 205918004097 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 205918004098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918004099 S-adenosylmethionine binding site [chemical binding]; other site 205918004100 Helix-turn-helix domains; Region: HTH; cl00088 205918004101 putative transposase OrfB; Reviewed; Region: PHA02517 205918004102 HTH-like domain; Region: HTH_21; pfam13276 205918004103 Integrase core domain; Region: rve; cl01316 205918004104 Integrase core domain; Region: rve_3; cl15866 205918004105 LysE type translocator; Region: LysE; cl00565 205918004106 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004107 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004108 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004109 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004110 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004111 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 205918004112 AMP-binding enzyme; Region: AMP-binding; cl15778 205918004113 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 205918004114 1 probable transmembrane helix predicted by TMHMM2.0 205918004115 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 205918004116 1 probable transmembrane helix predicted by TMHMM2.0 205918004117 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 205918004118 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918004119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918004120 DNA binding residues [nucleotide binding] 205918004121 dimerization interface [polypeptide binding]; other site 205918004122 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 205918004123 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 205918004124 Zn2+ binding site [ion binding]; other site 205918004125 Mg2+ binding site [ion binding]; other site 205918004126 Flavin Reductases; Region: FlaRed; cl00801 205918004127 pyrimidine utilization protein D; Region: RutD; TIGR03611 205918004128 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918004129 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 205918004130 homotrimer interaction site [polypeptide binding]; other site 205918004131 putative active site [active] 205918004132 Isochorismatase family; Region: Isochorismatase; pfam00857 205918004133 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 205918004134 catalytic triad [active] 205918004135 conserved cis-peptide bond; other site 205918004136 pyrimidine utilization protein A; Region: RutA; TIGR03612 205918004137 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 205918004138 active site 205918004139 dimer interface [polypeptide binding]; other site 205918004140 non-prolyl cis peptide bond; other site 205918004141 insertion regions; other site 205918004142 1 probable transmembrane helix predicted by TMHMM2.0 205918004143 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 205918004144 Helix-turn-helix domains; Region: HTH; cl00088 205918004145 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 205918004146 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 205918004147 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 205918004148 putative ligand binding site [chemical binding]; other site 205918004149 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 205918004150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918004151 Walker A/P-loop; other site 205918004152 ATP binding site [chemical binding]; other site 205918004153 Q-loop/lid; other site 205918004154 ABC transporter signature motif; other site 205918004155 Walker B; other site 205918004156 D-loop; other site 205918004157 H-loop/switch region; other site 205918004158 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 205918004159 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 205918004160 TM-ABC transporter signature motif; other site 205918004161 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004162 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004163 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004164 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004165 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004166 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004167 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004168 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004169 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004170 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004171 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 205918004172 TM-ABC transporter signature motif; other site 205918004173 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004174 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004175 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004176 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004177 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004178 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004179 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004180 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004181 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004182 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918004183 ligand binding site [chemical binding]; other site 205918004184 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 205918004185 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 205918004186 putative acyl-acceptor binding pocket; other site 205918004187 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004188 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004189 phosphate acetyltransferase; Reviewed; Region: PRK05632 205918004190 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918004191 DRTGG domain; Region: DRTGG; cl12147 205918004192 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 205918004193 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 205918004194 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 205918004195 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 205918004196 catalytic residues [active] 205918004197 dimer interface [polypeptide binding]; other site 205918004198 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 205918004199 putative active site [active] 205918004200 putative FMN binding site [chemical binding]; other site 205918004201 putative substrate binding site [chemical binding]; other site 205918004202 putative catalytic residue [active] 205918004203 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 205918004204 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 205918004205 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004206 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004207 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004208 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004209 thioredoxin reductase; Provisional; Region: PRK10262 205918004210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918004211 HopJ type III effector protein; Region: HopJ; pfam08888 205918004212 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 205918004213 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 205918004214 homooctamer interface [polypeptide binding]; other site 205918004215 active site 205918004216 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 205918004217 homodecamer interface [polypeptide binding]; other site 205918004218 GTP cyclohydrolase I; Provisional; Region: PLN03044 205918004219 active site 205918004220 putative catalytic site residues [active] 205918004221 zinc binding site [ion binding]; other site 205918004222 GTP-CH-I/GFRP interaction surface; other site 205918004223 dihydromonapterin reductase; Provisional; Region: PRK06483 205918004224 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 205918004225 NADP binding site [chemical binding]; other site 205918004226 substrate binding pocket [chemical binding]; other site 205918004227 active site 205918004228 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 205918004229 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004230 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004231 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 205918004232 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 205918004233 homodimer interface [polypeptide binding]; other site 205918004234 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 205918004235 NAD binding site [chemical binding]; other site 205918004236 active site 205918004237 Uncharacterized conserved protein [Function unknown]; Region: COG2912 205918004238 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 205918004239 hypothetical protein; Provisional; Region: PRK09936 205918004240 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 205918004241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 205918004242 TPR motif; other site 205918004243 binding surface 205918004244 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 205918004245 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 205918004246 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918004247 active site 205918004248 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 205918004249 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004250 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004251 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004252 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004253 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 205918004254 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004255 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004256 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 205918004257 active site 205918004258 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 205918004259 homodimer interface [polypeptide binding]; other site 205918004260 YebG protein; Region: YebG; cl01217 205918004261 Phosphate-starvation-inducible E; Region: PsiE; cl01264 205918004262 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004263 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004264 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004265 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004266 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 205918004267 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250 205918004268 30S subunit binding site; other site 205918004269 Secretin and TonB N terminus short domain; Region: STN; cl06624 205918004270 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 205918004271 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918004272 N-terminal plug; other site 205918004273 ligand-binding site [chemical binding]; other site 205918004274 fec operon regulator FecR; Reviewed; Region: PRK09774 205918004275 FecR protein; Region: FecR; pfam04773 205918004276 RNA polymerase sigma factor; Provisional; Region: PRK12528 205918004277 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918004278 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918004279 DNA binding residues [nucleotide binding] 205918004280 Cupin domain; Region: Cupin_2; cl09118 205918004281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918004282 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918004283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918004284 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004285 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004286 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004287 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004288 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004289 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004290 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004291 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004292 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004293 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004294 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 205918004295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918004296 transcriptional regulator; Provisional; Region: PRK10632 205918004297 Helix-turn-helix domains; Region: HTH; cl00088 205918004298 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918004299 putative effector binding pocket; other site 205918004300 dimerization interface [polypeptide binding]; other site 205918004301 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918004302 1 probable transmembrane helix predicted by TMHMM2.0 205918004303 Fusaric acid resistance protein family; Region: FUSC; pfam04632 205918004304 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 205918004305 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004306 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004307 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004308 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004309 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004310 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004311 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004312 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004313 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004314 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004315 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 205918004316 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004317 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004318 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 205918004319 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918004320 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918004321 1 probable transmembrane helix predicted by TMHMM2.0 205918004322 short chain dehydrogenase; Provisional; Region: PRK05693 205918004323 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 205918004324 NADP binding site [chemical binding]; other site 205918004325 active site 205918004326 steroid binding site; other site 205918004327 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004328 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004329 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918004330 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918004331 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 205918004332 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 205918004333 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 205918004334 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 205918004335 Substrate binding site; other site 205918004336 Cupin domain; Region: Cupin_2; cl09118 205918004337 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 205918004338 1 probable transmembrane helix predicted by TMHMM2.0 205918004339 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 205918004340 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004341 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004342 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004343 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004344 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004345 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004346 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004347 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004348 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004349 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 205918004350 active site 205918004351 Right handed beta helix region; Region: Beta_helix; pfam13229 205918004352 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 205918004353 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 205918004354 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 205918004355 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 205918004356 Sel1 repeat; Region: Sel1; cl02723 205918004357 PilZ domain; Region: PilZ; cl01260 205918004358 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918004359 1 probable transmembrane helix predicted by TMHMM2.0 205918004360 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 205918004361 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918004362 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004363 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004364 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004365 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004366 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 205918004367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918004368 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 205918004369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918004370 Protein of unknown function (DUF328); Region: DUF328; cl01143 205918004371 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 205918004372 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 205918004373 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 205918004374 putative active site [active] 205918004375 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918004376 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 205918004377 trimer interface [polypeptide binding]; other site 205918004378 dimer interface [polypeptide binding]; other site 205918004379 putative active site [active] 205918004380 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 205918004381 MoaE interaction surface [polypeptide binding]; other site 205918004382 MoeB interaction surface [polypeptide binding]; other site 205918004383 thiocarboxylated glycine; other site 205918004384 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 205918004385 MoaE homodimer interface [polypeptide binding]; other site 205918004386 MoaD interaction [polypeptide binding]; other site 205918004387 active site residues [active] 205918004388 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 205918004389 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 205918004390 ATP binding site [chemical binding]; other site 205918004391 Mg++ binding site [ion binding]; other site 205918004392 motif III; other site 205918004393 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918004394 nucleotide binding region [chemical binding]; other site 205918004395 ATP-binding site [chemical binding]; other site 205918004396 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 205918004397 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918004398 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918004399 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 205918004400 substrate binding pocket [chemical binding]; other site 205918004401 membrane-bound complex binding site; other site 205918004402 hinge residues; other site 205918004403 1 probable transmembrane helix predicted by TMHMM2.0 205918004404 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 205918004405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 205918004406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918004407 dimer interface [polypeptide binding]; other site 205918004408 conserved gate region; other site 205918004409 putative PBP binding loops; other site 205918004410 ABC-ATPase subunit interface; other site 205918004411 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004412 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004413 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004414 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004415 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004416 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004417 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004418 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004419 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918004420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918004421 dimer interface [polypeptide binding]; other site 205918004422 conserved gate region; other site 205918004423 putative PBP binding loops; other site 205918004424 ABC-ATPase subunit interface; other site 205918004425 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004426 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004427 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004428 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004429 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004430 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004431 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004432 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918004433 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918004434 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 205918004435 Walker A/P-loop; other site 205918004436 ATP binding site [chemical binding]; other site 205918004437 Q-loop/lid; other site 205918004438 ABC transporter signature motif; other site 205918004439 Walker B; other site 205918004440 D-loop; other site 205918004441 H-loop/switch region; other site 205918004442 cyanate transporter; Region: CynX; TIGR00896 205918004443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918004444 putative substrate translocation pore; other site 205918004445 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004446 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004447 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004448 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004449 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004450 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004451 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004452 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004453 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004454 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004455 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004456 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004457 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 205918004458 NmrA-like family; Region: NmrA; pfam05368 205918004459 NAD(P) binding site [chemical binding]; other site 205918004460 active site lysine 205918004461 Helix-turn-helix domains; Region: HTH; cl00088 205918004462 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 205918004463 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 205918004464 GIY-YIG motif/motif A; other site 205918004465 putative active site [active] 205918004466 putative metal binding site [ion binding]; other site 205918004467 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918004468 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 205918004469 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 205918004470 substrate binding pocket (H-site) [chemical binding]; other site 205918004471 N-terminal domain interface [polypeptide binding]; other site 205918004472 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 205918004473 catalytic residues [active] 205918004474 Nucleoid-associated protein [General function prediction only]; Region: COG3081 205918004475 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 205918004476 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 205918004477 IHF dimer interface [polypeptide binding]; other site 205918004478 IHF - DNA interface [nucleotide binding]; other site 205918004479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918004480 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 205918004481 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 205918004482 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 205918004483 HIGH motif; other site 205918004484 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 205918004485 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 205918004486 active site 205918004487 KMSKS motif; other site 205918004488 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 205918004489 tRNA binding surface [nucleotide binding]; other site 205918004490 anticodon binding site; other site 205918004491 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 205918004492 hypothetical protein 205918004493 hypothetical protein 205918004494 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 205918004495 multifunctional aminopeptidase A; Provisional; Region: PRK00913 205918004496 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 205918004497 interface (dimer of trimers) [polypeptide binding]; other site 205918004498 Substrate-binding/catalytic site; other site 205918004499 Zn-binding sites [ion binding]; other site 205918004500 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 205918004501 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 205918004502 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004503 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004504 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004505 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004506 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004507 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004508 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 205918004509 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004510 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004511 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004512 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004513 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004514 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004515 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 205918004516 DNA-binding site [nucleotide binding]; DNA binding site 205918004517 RNA-binding motif; other site 205918004518 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 205918004519 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 205918004520 glycine dehydrogenase; Provisional; Region: PRK05367 205918004521 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 205918004522 tetramer interface [polypeptide binding]; other site 205918004523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918004524 catalytic residue [active] 205918004525 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 205918004526 tetramer interface [polypeptide binding]; other site 205918004527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918004528 catalytic residue [active] 205918004529 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 205918004530 lipoyl attachment site [posttranslational modification]; other site 205918004531 response regulator PleD; Reviewed; Region: pleD; PRK09581 205918004532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918004533 active site 205918004534 phosphorylation site [posttranslational modification] 205918004535 intermolecular recognition site; other site 205918004536 dimerization interface [polypeptide binding]; other site 205918004537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918004538 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918004539 metal binding site [ion binding]; metal-binding site 205918004540 active site 205918004541 I-site; other site 205918004542 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918004543 Response regulator receiver domain; Region: Response_reg; pfam00072 205918004544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918004545 active site 205918004546 phosphorylation site [posttranslational modification] 205918004547 intermolecular recognition site; other site 205918004548 dimerization interface [polypeptide binding]; other site 205918004549 PAS domain; Region: PAS_9; pfam13426 205918004550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918004551 putative active site [active] 205918004552 heme pocket [chemical binding]; other site 205918004553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918004554 PAS domain; Region: PAS_9; pfam13426 205918004555 putative active site [active] 205918004556 heme pocket [chemical binding]; other site 205918004557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918004558 dimer interface [polypeptide binding]; other site 205918004559 phosphorylation site [posttranslational modification] 205918004560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918004561 ATP binding site [chemical binding]; other site 205918004562 Mg2+ binding site [ion binding]; other site 205918004563 G-X-G motif; other site 205918004564 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 205918004565 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 205918004566 putative aromatic amino acid binding site; other site 205918004567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918004568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918004569 Walker A motif; other site 205918004570 ATP binding site [chemical binding]; other site 205918004571 Walker B motif; other site 205918004572 arginine finger; other site 205918004573 Protein of unknown function (DUF454); Region: DUF454; cl01063 205918004574 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004575 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004576 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 205918004577 heme binding pocket [chemical binding]; other site 205918004578 heme ligand [chemical binding]; other site 205918004579 Secretin and TonB N terminus short domain; Region: STN; cl06624 205918004580 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 205918004581 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918004582 N-terminal plug; other site 205918004583 ligand-binding site [chemical binding]; other site 205918004584 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 205918004585 FecR protein; Region: FecR; pfam04773 205918004586 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 205918004587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918004588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918004589 DNA binding residues [nucleotide binding] 205918004590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918004591 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 205918004592 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 205918004593 Dehydratase family; Region: ILVD_EDD; cl00340 205918004594 6-phosphogluconate dehydratase; Region: edd; TIGR01196 205918004595 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205918004596 glucokinase, proteobacterial type; Region: glk; TIGR00749 205918004597 osmolarity response regulator; Provisional; Region: ompR; PRK09468 205918004598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918004599 active site 205918004600 phosphorylation site [posttranslational modification] 205918004601 intermolecular recognition site; other site 205918004602 dimerization interface [polypeptide binding]; other site 205918004603 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918004604 DNA binding site [nucleotide binding] 205918004605 sensor protein RstB; Provisional; Region: PRK10604 205918004606 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918004607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918004608 ATP binding site [chemical binding]; other site 205918004609 Mg2+ binding site [ion binding]; other site 205918004610 G-X-G motif; other site 205918004611 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004612 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004613 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205918004614 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918004615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918004616 dimer interface [polypeptide binding]; other site 205918004617 conserved gate region; other site 205918004618 putative PBP binding loops; other site 205918004619 ABC-ATPase subunit interface; other site 205918004620 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004621 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004622 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004623 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004624 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004625 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004626 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205918004627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918004628 dimer interface [polypeptide binding]; other site 205918004629 conserved gate region; other site 205918004630 putative PBP binding loops; other site 205918004631 ABC-ATPase subunit interface; other site 205918004632 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004633 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004634 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004635 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004636 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004637 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004638 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918004639 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 205918004640 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 205918004641 Walker A/P-loop; other site 205918004642 ATP binding site [chemical binding]; other site 205918004643 Q-loop/lid; other site 205918004644 ABC transporter signature motif; other site 205918004645 Walker B; other site 205918004646 D-loop; other site 205918004647 H-loop/switch region; other site 205918004648 TOBE domain; Region: TOBE_2; cl01440 205918004649 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 205918004650 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 205918004651 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 205918004652 active site 205918004653 phosphate binding residues; other site 205918004654 catalytic residues [active] 205918004655 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 205918004656 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 205918004657 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 205918004658 putative active site [active] 205918004659 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 205918004660 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 205918004661 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 205918004662 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 205918004663 putative active site [active] 205918004664 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 205918004665 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 205918004666 active site 205918004667 intersubunit interface [polypeptide binding]; other site 205918004668 catalytic residue [active] 205918004669 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 205918004670 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 205918004671 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918004672 metal binding site [ion binding]; metal-binding site 205918004673 active site 205918004674 I-site; other site 205918004675 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004676 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004677 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 205918004678 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918004679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918004680 dimer interface [polypeptide binding]; other site 205918004681 phosphorylation site [posttranslational modification] 205918004682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918004683 ATP binding site [chemical binding]; other site 205918004684 Mg2+ binding site [ion binding]; other site 205918004685 G-X-G motif; other site 205918004686 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004687 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004688 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 205918004689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918004690 active site 205918004691 phosphorylation site [posttranslational modification] 205918004692 intermolecular recognition site; other site 205918004693 dimerization interface [polypeptide binding]; other site 205918004694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918004695 DNA binding site [nucleotide binding] 205918004696 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 205918004697 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004698 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004699 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004700 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004701 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004702 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004703 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004704 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004705 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004706 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004707 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004708 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004709 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 205918004710 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918004711 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918004712 1 probable transmembrane helix predicted by TMHMM2.0 205918004713 1 probable transmembrane helix predicted by TMHMM2.0 205918004714 Fimbrial protein; Region: Fimbrial; cl01416 205918004715 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 205918004716 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 205918004717 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 205918004718 1 probable transmembrane helix predicted by TMHMM2.0 205918004719 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 205918004720 PapC N-terminal domain; Region: PapC_N; pfam13954 205918004721 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 205918004722 PapC C-terminal domain; Region: PapC_C; pfam13953 205918004723 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 205918004724 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 205918004725 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 205918004726 Fimbrial protein; Region: Fimbrial; cl01416 205918004727 Flagellin N-methylase; Region: FliB; cl00497 205918004728 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918004729 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 205918004730 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918004731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918004732 active site 205918004733 phosphorylation site [posttranslational modification] 205918004734 intermolecular recognition site; other site 205918004735 dimerization interface [polypeptide binding]; other site 205918004736 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 205918004737 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004738 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004739 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004740 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918004741 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 205918004742 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 205918004743 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 205918004744 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004745 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004746 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004747 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 205918004748 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 205918004749 D-pathway; other site 205918004750 Putative ubiquinol binding site [chemical binding]; other site 205918004751 Low-spin heme (heme b) binding site [chemical binding]; other site 205918004752 Putative water exit pathway; other site 205918004753 Binuclear center (heme o3/CuB) [ion binding]; other site 205918004754 K-pathway; other site 205918004755 Putative proton exit pathway; other site 205918004756 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004757 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004758 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004759 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004760 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004761 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004762 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004763 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004764 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004765 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004766 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004767 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004768 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004769 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918004770 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 205918004771 Subunit I/III interface [polypeptide binding]; other site 205918004772 Subunit III/IV interface [polypeptide binding]; other site 205918004773 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004774 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004775 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004776 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004777 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918004778 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 205918004779 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004780 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004781 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004782 UbiA prenyltransferase family; Region: UbiA; cl00337 205918004783 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004784 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004785 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004786 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004787 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004788 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004789 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004790 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004791 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004792 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 205918004793 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205918004794 active site 205918004795 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 205918004796 trimer interface [polypeptide binding]; other site 205918004797 active site 205918004798 substrate binding site [chemical binding]; other site 205918004799 CoA binding site [chemical binding]; other site 205918004800 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 205918004801 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 205918004802 homodimer interface [polypeptide binding]; other site 205918004803 substrate-cofactor binding pocket; other site 205918004804 catalytic residue [active] 205918004805 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918004806 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918004807 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918004808 dimer interface [polypeptide binding]; other site 205918004809 putative CheW interface [polypeptide binding]; other site 205918004810 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004811 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918004812 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918004813 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918004814 substrate binding pocket [chemical binding]; other site 205918004815 membrane-bound complex binding site; other site 205918004816 hinge residues; other site 205918004817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918004818 dimerization interface [polypeptide binding]; other site 205918004819 putative DNA binding site [nucleotide binding]; other site 205918004820 putative Zn2+ binding site [ion binding]; other site 205918004821 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 205918004822 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 205918004823 putative NAD(P) binding site [chemical binding]; other site 205918004824 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 205918004825 E-class dimer interface [polypeptide binding]; other site 205918004826 P-class dimer interface [polypeptide binding]; other site 205918004827 active site 205918004828 Cu2+ binding site [ion binding]; other site 205918004829 Zn2+ binding site [ion binding]; other site 205918004830 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 205918004831 hypothetical protein; Provisional; Region: PRK06156 205918004832 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 205918004833 active site 205918004834 metal binding site [ion binding]; metal-binding site 205918004835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918004836 PAS domain; Region: PAS_9; pfam13426 205918004837 putative active site [active] 205918004838 heme pocket [chemical binding]; other site 205918004839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918004840 PAS domain; Region: PAS_9; pfam13426 205918004841 putative active site [active] 205918004842 heme pocket [chemical binding]; other site 205918004843 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918004844 metal binding site [ion binding]; metal-binding site 205918004845 active site 205918004846 I-site; other site 205918004847 GntP family permease; Region: GntP_permease; pfam02447 205918004848 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 205918004849 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004850 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004851 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004852 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004853 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004854 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004855 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004856 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004857 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004858 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004859 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918004860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918004861 PAS domain; Region: PAS_9; pfam13426 205918004862 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918004863 putative active site [active] 205918004864 heme pocket [chemical binding]; other site 205918004865 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918004866 metal binding site [ion binding]; metal-binding site 205918004867 active site 205918004868 I-site; other site 205918004869 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918004870 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918004871 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918004872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918004873 DNA-binding site [nucleotide binding]; DNA binding site 205918004874 FCD domain; Region: FCD; cl11656 205918004875 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 205918004876 Isochorismatase family; Region: Isochorismatase; pfam00857 205918004877 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 205918004878 catalytic triad [active] 205918004879 conserved cis-peptide bond; other site 205918004880 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 205918004881 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 205918004882 Walker A/P-loop; other site 205918004883 ATP binding site [chemical binding]; other site 205918004884 Q-loop/lid; other site 205918004885 ABC transporter signature motif; other site 205918004886 Walker B; other site 205918004887 D-loop; other site 205918004888 H-loop/switch region; other site 205918004889 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 205918004890 Isochorismatase family; Region: Isochorismatase; pfam00857 205918004891 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 205918004892 catalytic triad [active] 205918004893 conserved cis-peptide bond; other site 205918004894 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 205918004895 Predicted amidohydrolase [General function prediction only]; Region: COG0388 205918004896 multimer interface [polypeptide binding]; other site 205918004897 active site 205918004898 catalytic triad [active] 205918004899 dimer interface [polypeptide binding]; other site 205918004900 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 205918004901 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 205918004902 TM-ABC transporter signature motif; other site 205918004903 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004904 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004905 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004906 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004907 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004908 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004909 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004910 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004911 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918004912 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 205918004913 TM-ABC transporter signature motif; other site 205918004914 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004915 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004916 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004917 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004918 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004919 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004920 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004921 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004922 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004923 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918004924 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 205918004925 putative ligand binding site [chemical binding]; other site 205918004926 allophanate hydrolase; Provisional; Region: PRK08186 205918004927 Amidase; Region: Amidase; cl11426 205918004928 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 205918004929 dimer interface [polypeptide binding]; other site 205918004930 ligand binding site [chemical binding]; other site 205918004931 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918004932 Helix-turn-helix domains; Region: HTH; cl00088 205918004933 AsnC family; Region: AsnC_trans_reg; pfam01037 205918004934 LysE type translocator; Region: LysE; cl00565 205918004935 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004936 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004937 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004938 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004939 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004940 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918004941 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 205918004942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918004943 putative substrate translocation pore; other site 205918004944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918004945 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004946 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004947 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004948 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004949 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004950 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004951 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004952 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004953 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004954 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004955 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004956 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918004957 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918004958 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 205918004959 putative C-terminal domain interface [polypeptide binding]; other site 205918004960 putative GSH binding site (G-site) [chemical binding]; other site 205918004961 putative dimer interface [polypeptide binding]; other site 205918004962 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 205918004963 putative N-terminal domain interface [polypeptide binding]; other site 205918004964 putative dimer interface [polypeptide binding]; other site 205918004965 putative substrate binding pocket (H-site) [chemical binding]; other site 205918004966 putative transposase OrfB; Reviewed; Region: PHA02517 205918004967 HTH-like domain; Region: HTH_21; pfam13276 205918004968 Integrase core domain; Region: rve; cl01316 205918004969 Integrase core domain; Region: rve_3; cl15866 205918004970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918004971 Helix-turn-helix domains; Region: HTH; cl00088 205918004972 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 205918004973 OPT oligopeptide transporter protein; Region: OPT; cl14607 205918004974 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918004975 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918004976 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918004977 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918004978 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918004979 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918004980 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918004981 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918004982 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918004983 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918004984 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918004985 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918004986 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918004987 AAA domain; Region: AAA_33; pfam13671 205918004988 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918004989 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 205918004990 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 205918004991 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004992 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004993 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918004994 Pectate lyase; Region: Pectate_lyase; pfam03211 205918004995 Tir chaperone protein (CesT) family; Region: CesT; cl08444 205918004996 Tir chaperone protein (CesT) family; Region: CesT; cl08444 205918004997 Pathogenicity factor; Region: AvrE; pfam11725 205918004998 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 205918004999 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918005000 catalytic residue [active] 205918005001 cell division protein ZipA; Provisional; Region: PRK03427 205918005002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918005003 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 205918005004 Walker A motif; other site 205918005005 ATP binding site [chemical binding]; other site 205918005006 Walker B motif; other site 205918005007 arginine finger; other site 205918005008 Helix-turn-helix domains; Region: HTH; cl00088 205918005009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918005010 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205918005011 Walker A motif; other site 205918005012 ATP binding site [chemical binding]; other site 205918005013 Walker B motif; other site 205918005014 arginine finger; other site 205918005015 Helix-turn-helix domains; Region: HTH; cl00088 205918005016 HrpA pilus formation protein; Region: HrpA_pilin; pfam09589 205918005017 HrpZ; Region: Hairpins; pfam04877 205918005018 HrpZ; Region: Hairpins; pfam04877 205918005019 Type III secretion needle MxiH like; Region: MxiH; cl09641 205918005020 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 205918005021 1 probable transmembrane helix predicted by TMHMM2.0 205918005022 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 205918005023 HrpF protein; Region: HrpF; pfam06266 205918005024 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 205918005025 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918005026 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918005027 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 205918005028 1 probable transmembrane helix predicted by TMHMM2.0 205918005029 AAA domain; Region: AAA_21; pfam13304 205918005030 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 205918005031 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 205918005032 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005033 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005034 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005035 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 205918005036 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005037 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005038 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005039 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005040 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005041 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005042 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 205918005043 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005044 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005045 FliP family; Region: FliP; cl00593 205918005046 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005047 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005048 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005049 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005050 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 205918005051 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 205918005052 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 205918005053 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 205918005054 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 205918005055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918005056 Walker A motif; other site 205918005057 ATP binding site [chemical binding]; other site 205918005058 Walker B motif; other site 205918005059 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 205918005060 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 205918005061 FHIPEP family; Region: FHIPEP; pfam00771 205918005062 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005063 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005064 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005065 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005066 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005067 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005068 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005069 HrpJ-like domain; Region: HrpJ; cl15454 205918005070 TyeA; Region: TyeA; cl07611 205918005071 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 205918005072 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918005073 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918005074 DNA binding residues [nucleotide binding] 205918005075 1 probable transmembrane helix predicted by TMHMM2.0 205918005076 Avirulence protein; Region: AvrB_AvrC; pfam05394 205918005077 Transposase IS66 205918005078 ISPsy5, transposase 205918005079 IS66 Orf2 like 205918005080 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 205918005081 Tir chaperone protein (CesT) family; Region: CesT; cl08444 205918005082 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 205918005083 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 205918005084 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 205918005085 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 205918005086 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 205918005087 Preprotein translocase subunit; Region: YajC; cl00806 205918005088 1 probable transmembrane helix predicted by TMHMM2.0 205918005089 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 205918005090 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 205918005091 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 205918005092 Protein export membrane protein; Region: SecD_SecF; cl14618 205918005093 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005094 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005095 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005096 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005097 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005098 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005099 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 205918005100 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 205918005101 Protein export membrane protein; Region: SecD_SecF; cl14618 205918005102 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005103 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005104 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005105 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005106 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005107 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918005108 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 205918005109 1 probable transmembrane helix predicted by TMHMM2.0 205918005110 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 205918005111 active site 205918005112 dimerization interface [polypeptide binding]; other site 205918005113 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 205918005114 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 205918005115 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 205918005116 serine O-acetyltransferase; Region: cysE; TIGR01172 205918005117 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 205918005118 trimer interface [polypeptide binding]; other site 205918005119 active site 205918005120 substrate binding site [chemical binding]; other site 205918005121 CoA binding site [chemical binding]; other site 205918005122 Helix-turn-helix domains; Region: HTH; cl00088 205918005123 Rrf2 family protein; Region: rrf2_super; TIGR00738 205918005124 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205918005125 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 205918005126 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918005127 catalytic residue [active] 205918005128 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 205918005129 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 205918005130 trimerization site [polypeptide binding]; other site 205918005131 active site 205918005132 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 205918005133 co-chaperone HscB; Provisional; Region: hscB; PRK00294 205918005134 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918005135 HSP70 interaction site [polypeptide binding]; other site 205918005136 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 205918005137 chaperone protein HscA; Provisional; Region: hscA; PRK05183 205918005138 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 205918005139 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205918005140 catalytic loop [active] 205918005141 iron binding site [ion binding]; other site 205918005142 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 205918005143 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 205918005144 active site 205918005145 multimer interface [polypeptide binding]; other site 205918005146 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 205918005147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918005148 FeS/SAM binding site; other site 205918005149 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 205918005150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918005151 binding surface 205918005152 TPR motif; other site 205918005153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 205918005154 binding surface 205918005155 TPR motif; other site 205918005156 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 205918005157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 205918005158 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 205918005159 1 probable transmembrane helix predicted by TMHMM2.0 205918005160 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 205918005161 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 205918005162 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 205918005163 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 205918005164 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 205918005165 dimer interface [polypeptide binding]; other site 205918005166 motif 1; other site 205918005167 active site 205918005168 motif 2; other site 205918005169 motif 3; other site 205918005170 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 205918005171 anticodon binding site; other site 205918005172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 205918005173 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 205918005174 1 probable transmembrane helix predicted by TMHMM2.0 205918005175 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 205918005176 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 205918005177 Trp docking motif [polypeptide binding]; other site 205918005178 GTP-binding protein Der; Reviewed; Region: PRK00093 205918005179 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 205918005180 G1 box; other site 205918005181 GTP/Mg2+ binding site [chemical binding]; other site 205918005182 Switch I region; other site 205918005183 G2 box; other site 205918005184 Switch II region; other site 205918005185 G3 box; other site 205918005186 G4 box; other site 205918005187 G5 box; other site 205918005188 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 205918005189 G1 box; other site 205918005190 GTP/Mg2+ binding site [chemical binding]; other site 205918005191 Switch I region; other site 205918005192 G2 box; other site 205918005193 G3 box; other site 205918005194 Switch II region; other site 205918005195 G4 box; other site 205918005196 G5 box; other site 205918005197 methionine aminotransferase; Validated; Region: PRK09082 205918005198 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918005199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918005200 homodimer interface [polypeptide binding]; other site 205918005201 catalytic residue [active] 205918005202 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 205918005203 Predicted amidohydrolase [General function prediction only]; Region: COG0388 205918005204 putative active site [active] 205918005205 catalytic triad [active] 205918005206 dimer interface [polypeptide binding]; other site 205918005207 multimer interface [polypeptide binding]; other site 205918005208 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 205918005209 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 205918005210 tetramer interface [polypeptide binding]; other site 205918005211 active site 205918005212 Mg2+/Mn2+ binding site [ion binding]; other site 205918005213 2-isopropylmalate synthase; Validated; Region: PRK03739 205918005214 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 205918005215 active site 205918005216 catalytic residues [active] 205918005217 metal binding site [ion binding]; metal-binding site 205918005218 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 205918005219 Peptidase family M23; Region: Peptidase_M23; pfam01551 205918005220 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 205918005221 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 205918005222 generic binding surface II; other site 205918005223 generic binding surface I; other site 205918005224 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 205918005225 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 205918005226 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 205918005227 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 205918005228 active site 205918005229 GMP synthase; Reviewed; Region: guaA; PRK00074 205918005230 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 205918005231 AMP/PPi binding site [chemical binding]; other site 205918005232 candidate oxyanion hole; other site 205918005233 catalytic triad [active] 205918005234 potential glutamine specificity residues [chemical binding]; other site 205918005235 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 205918005236 ATP Binding subdomain [chemical binding]; other site 205918005237 Ligand Binding sites [chemical binding]; other site 205918005238 Dimerization subdomain; other site 205918005239 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 205918005240 tetratricopeptide repeat protein; Provisional; Region: PRK11788 205918005241 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 205918005242 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 205918005243 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 205918005244 1 probable transmembrane helix predicted by TMHMM2.0 205918005245 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 205918005246 nucleoside/Zn binding site; other site 205918005247 dimer interface [polypeptide binding]; other site 205918005248 catalytic motif [active] 205918005249 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 205918005250 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918005251 substrate binding pocket [chemical binding]; other site 205918005252 membrane-bound complex binding site; other site 205918005253 hinge residues; other site 205918005254 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 205918005255 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918005256 catalytic residue [active] 205918005257 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 205918005258 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 205918005259 dimerization interface [polypeptide binding]; other site 205918005260 ATP binding site [chemical binding]; other site 205918005261 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 205918005262 dimerization interface [polypeptide binding]; other site 205918005263 ATP binding site [chemical binding]; other site 205918005264 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 205918005265 putative active site [active] 205918005266 catalytic triad [active] 205918005267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 205918005268 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 205918005269 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 205918005270 nudix motif; other site 205918005271 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 205918005272 putative active site [active] 205918005273 putative CoA binding site [chemical binding]; other site 205918005274 nudix motif; other site 205918005275 metal binding site [ion binding]; metal-binding site 205918005276 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 205918005277 trimer interface [polypeptide binding]; other site 205918005278 putative metal binding site [ion binding]; other site 205918005279 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 205918005280 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 205918005281 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005282 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005283 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005284 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005285 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 205918005286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918005287 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918005288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918005289 metabolite-proton symporter; Region: 2A0106; TIGR00883 205918005290 putative substrate translocation pore; other site 205918005291 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005292 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005293 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005294 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005295 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005296 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005297 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005298 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005299 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005300 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005301 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918005302 Domain of unknown function DUF21; Region: DUF21; pfam01595 205918005303 hypothetical protein; Provisional; Region: PRK11573 205918005304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205918005305 Transporter associated domain; Region: CorC_HlyC; cl08393 205918005306 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005307 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005308 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005309 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005310 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 205918005311 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005312 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005313 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005314 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005315 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005316 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005317 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005318 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918005319 signal recognition particle protein; Provisional; Region: PRK10867 205918005320 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 205918005321 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 205918005322 P loop; other site 205918005323 GTP binding site [chemical binding]; other site 205918005324 Signal peptide binding domain; Region: SRP_SPB; pfam02978 205918005325 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 205918005326 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 205918005327 RimM N-terminal domain; Region: RimM; pfam01782 205918005328 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 205918005329 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 205918005330 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 205918005331 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 205918005332 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 205918005333 active site 205918005334 Int/Topo IB signature motif; other site 205918005335 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 205918005336 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 205918005337 dimerization domain [polypeptide binding]; other site 205918005338 dimer interface [polypeptide binding]; other site 205918005339 catalytic residues [active] 205918005340 homoserine dehydrogenase; Provisional; Region: PRK06349 205918005341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918005342 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 205918005343 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 205918005344 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 205918005345 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 205918005346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918005347 catalytic residue [active] 205918005348 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 205918005349 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918005350 substrate binding pocket [chemical binding]; other site 205918005351 membrane-bound complex binding site; other site 205918005352 hinge residues; other site 205918005353 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918005354 substrate binding pocket [chemical binding]; other site 205918005355 membrane-bound complex binding site; other site 205918005356 hinge residues; other site 205918005357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918005358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918005359 dimer interface [polypeptide binding]; other site 205918005360 phosphorylation site [posttranslational modification] 205918005361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918005362 ATP binding site [chemical binding]; other site 205918005363 Mg2+ binding site [ion binding]; other site 205918005364 G-X-G motif; other site 205918005365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005366 active site 205918005367 phosphorylation site [posttranslational modification] 205918005368 intermolecular recognition site; other site 205918005369 dimerization interface [polypeptide binding]; other site 205918005370 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 205918005371 1 probable transmembrane helix predicted by TMHMM2.0 205918005372 Response regulator receiver domain; Region: Response_reg; pfam00072 205918005373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005374 active site 205918005375 phosphorylation site [posttranslational modification] 205918005376 intermolecular recognition site; other site 205918005377 dimerization interface [polypeptide binding]; other site 205918005378 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918005379 transcriptional regulator RcsB; Provisional; Region: PRK10840 205918005380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005381 active site 205918005382 phosphorylation site [posttranslational modification] 205918005383 intermolecular recognition site; other site 205918005384 dimerization interface [polypeptide binding]; other site 205918005385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918005386 DNA binding residues [nucleotide binding] 205918005387 dimerization interface [polypeptide binding]; other site 205918005388 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 205918005389 conserved hypothetical protein; Region: TIGR02285 205918005390 YaeQ protein; Region: YaeQ; cl01913 205918005391 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 205918005392 DHH family; Region: DHH; pfam01368 205918005393 DHHA1 domain; Region: DHHA1; pfam02272 205918005394 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 205918005395 active site 205918005396 FMN binding site [chemical binding]; other site 205918005397 substrate binding site [chemical binding]; other site 205918005398 homotetramer interface [polypeptide binding]; other site 205918005399 catalytic residue [active] 205918005400 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 205918005401 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 205918005402 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918005403 putative active site [active] 205918005404 heme pocket [chemical binding]; other site 205918005405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918005406 dimer interface [polypeptide binding]; other site 205918005407 phosphorylation site [posttranslational modification] 205918005408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918005409 ATP binding site [chemical binding]; other site 205918005410 Mg2+ binding site [ion binding]; other site 205918005411 G-X-G motif; other site 205918005412 Response regulator receiver domain; Region: Response_reg; pfam00072 205918005413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005414 active site 205918005415 phosphorylation site [posttranslational modification] 205918005416 intermolecular recognition site; other site 205918005417 dimerization interface [polypeptide binding]; other site 205918005418 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 205918005419 putative metal binding site [ion binding]; other site 205918005420 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 205918005421 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918005422 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918005423 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918005424 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918005425 dimer interface [polypeptide binding]; other site 205918005426 putative CheW interface [polypeptide binding]; other site 205918005427 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005428 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005429 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 205918005430 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 205918005431 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 205918005432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918005433 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 205918005434 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918005435 putative binding surface; other site 205918005436 active site 205918005437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918005438 ATP binding site [chemical binding]; other site 205918005439 Mg2+ binding site [ion binding]; other site 205918005440 G-X-G motif; other site 205918005441 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 205918005442 Response regulator receiver domain; Region: Response_reg; pfam00072 205918005443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005444 active site 205918005445 phosphorylation site [posttranslational modification] 205918005446 intermolecular recognition site; other site 205918005447 dimerization interface [polypeptide binding]; other site 205918005448 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 205918005449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005450 active site 205918005451 phosphorylation site [posttranslational modification] 205918005452 intermolecular recognition site; other site 205918005453 dimerization interface [polypeptide binding]; other site 205918005454 CheB methylesterase; Region: CheB_methylest; pfam01339 205918005455 Response regulator receiver domain; Region: Response_reg; pfam00072 205918005456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005457 active site 205918005458 phosphorylation site [posttranslational modification] 205918005459 intermolecular recognition site; other site 205918005460 dimerization interface [polypeptide binding]; other site 205918005461 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918005462 metal binding site [ion binding]; metal-binding site 205918005463 active site 205918005464 I-site; other site 205918005465 peptide chain release factor 2; Region: prfB; TIGR00020 205918005466 RF-1 domain; Region: RF-1; cl02875 205918005467 RF-1 domain; Region: RF-1; cl02875 205918005468 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 205918005469 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 205918005470 dimer interface [polypeptide binding]; other site 205918005471 putative anticodon binding site; other site 205918005472 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 205918005473 motif 1; other site 205918005474 active site 205918005475 motif 2; other site 205918005476 motif 3; other site 205918005477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 205918005478 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 205918005479 conserved hypothetical protein; Region: QEGLA; TIGR02421 205918005480 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918005481 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 205918005482 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918005483 1 probable transmembrane helix predicted by TMHMM2.0 205918005484 CHASE3 domain; Region: CHASE3; cl05000 205918005485 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918005486 ligand binding site [chemical binding]; other site 205918005487 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 205918005488 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 205918005489 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 205918005490 adenylate kinase; Reviewed; Region: adk; PRK00279 205918005491 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 205918005492 AMP-binding site [chemical binding]; other site 205918005493 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 205918005494 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 205918005495 Protein of unknown function DUF72; Region: DUF72; cl00777 205918005496 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 205918005497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918005498 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 205918005499 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 205918005500 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 205918005501 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 205918005502 putative acyl-acceptor binding pocket; other site 205918005503 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 205918005504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918005505 S-adenosylmethionine binding site [chemical binding]; other site 205918005506 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 205918005507 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 205918005508 metal binding site [ion binding]; metal-binding site 205918005509 dimer interface [polypeptide binding]; other site 205918005510 Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191 205918005511 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 205918005512 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 205918005513 Ligand binding site; other site 205918005514 DXD motif; other site 205918005515 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005516 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005517 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005518 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005519 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005520 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005521 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005522 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 205918005523 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 205918005524 putative ATP binding site [chemical binding]; other site 205918005525 putative substrate interface [chemical binding]; other site 205918005526 Fe-S metabolism associated domain; Region: SufE; cl00951 205918005527 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 205918005528 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 205918005529 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918005530 catalytic residue [active] 205918005531 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 205918005532 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 205918005533 putative trimer interface [polypeptide binding]; other site 205918005534 putative CoA binding site [chemical binding]; other site 205918005535 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 205918005536 ArsC family; Region: ArsC; pfam03960 205918005537 putative catalytic residues [active] 205918005538 Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_3; cd04327 205918005539 active site 205918005540 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 205918005541 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918005542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918005543 homodimer interface [polypeptide binding]; other site 205918005544 catalytic residue [active] 205918005545 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 205918005546 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205918005547 metal binding triad; other site 205918005548 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 205918005549 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205918005550 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 205918005551 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 205918005552 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 205918005553 active site 205918005554 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 205918005555 rRNA interaction site [nucleotide binding]; other site 205918005556 S8 interaction site; other site 205918005557 putative laminin-1 binding site; other site 205918005558 elongation factor Ts; Provisional; Region: tsf; PRK09377 205918005559 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 205918005560 Elongation factor TS; Region: EF_TS; pfam00889 205918005561 Elongation factor TS; Region: EF_TS; pfam00889 205918005562 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 205918005563 putative nucleotide binding site [chemical binding]; other site 205918005564 uridine monophosphate binding site [chemical binding]; other site 205918005565 homohexameric interface [polypeptide binding]; other site 205918005566 ribosome recycling factor; Reviewed; Region: frr; PRK00083 205918005567 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 205918005568 hinge region; other site 205918005569 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 205918005570 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 205918005571 catalytic residue [active] 205918005572 putative FPP diphosphate binding site; other site 205918005573 putative FPP binding hydrophobic cleft; other site 205918005574 dimer interface [polypeptide binding]; other site 205918005575 putative IPP diphosphate binding site; other site 205918005576 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 205918005577 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005578 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005579 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005580 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005581 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005582 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005583 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918005584 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 205918005585 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 205918005586 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 205918005587 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 205918005588 zinc metallopeptidase RseP; Provisional; Region: PRK10779 205918005589 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 205918005590 active site 205918005591 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 205918005592 protein binding site [polypeptide binding]; other site 205918005593 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 205918005594 protein binding site [polypeptide binding]; other site 205918005595 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 205918005596 putative substrate binding region [chemical binding]; other site 205918005597 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005598 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005599 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005600 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918005601 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 205918005602 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 205918005603 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 205918005604 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 205918005605 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 205918005606 Surface antigen; Region: Bac_surface_Ag; cl03097 205918005607 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 205918005608 periplasmic chaperone; Provisional; Region: PRK10780 205918005609 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 205918005610 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 205918005611 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 205918005612 trimer interface [polypeptide binding]; other site 205918005613 active site 205918005614 UDP-GlcNAc binding site [chemical binding]; other site 205918005615 lipid binding site [chemical binding]; lipid-binding site 205918005616 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 205918005617 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 205918005618 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 205918005619 active site 205918005620 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 205918005621 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 205918005622 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 205918005623 RNA/DNA hybrid binding site [nucleotide binding]; other site 205918005624 active site 205918005625 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 205918005626 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 205918005627 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 205918005628 generic binding surface II; other site 205918005629 generic binding surface I; other site 205918005630 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 205918005631 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 205918005632 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 205918005633 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 205918005634 Ligand Binding Site [chemical binding]; other site 205918005635 TilS substrate binding domain; Region: TilS; pfam09179 205918005636 B3/4 domain; Region: B3_4; cl11458 205918005637 CTP synthetase; Validated; Region: pyrG; PRK05380 205918005638 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 205918005639 Catalytic site [active] 205918005640 active site 205918005641 UTP binding site [chemical binding]; other site 205918005642 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 205918005643 active site 205918005644 putative oxyanion hole; other site 205918005645 catalytic triad [active] 205918005646 1 probable transmembrane helix predicted by TMHMM2.0 205918005647 NeuB family; Region: NeuB; cl00496 205918005648 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 205918005649 enolase; Provisional; Region: eno; PRK00077 205918005650 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 205918005651 dimer interface [polypeptide binding]; other site 205918005652 metal binding site [ion binding]; metal-binding site 205918005653 substrate binding pocket [chemical binding]; other site 205918005654 Septum formation initiator; Region: DivIC; cl11433 205918005655 1 probable transmembrane helix predicted by TMHMM2.0 205918005656 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 205918005657 substrate binding site; other site 205918005658 dimer interface; other site 205918005659 1 probable transmembrane helix predicted by TMHMM2.0 205918005660 LysR family transcriptional regulator; Provisional; Region: PRK14997 205918005661 Helix-turn-helix domains; Region: HTH; cl00088 205918005662 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 205918005663 putative effector binding pocket; other site 205918005664 putative dimerization interface [polypeptide binding]; other site 205918005665 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 205918005666 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 205918005667 substrate binding site [chemical binding]; other site 205918005668 catalytic Zn binding site [ion binding]; other site 205918005669 NAD binding site [chemical binding]; other site 205918005670 structural Zn binding site [ion binding]; other site 205918005671 dimer interface [polypeptide binding]; other site 205918005672 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918005673 Predicted esterase [General function prediction only]; Region: COG0627 205918005674 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 205918005675 homotrimer interaction site [polypeptide binding]; other site 205918005676 zinc binding site [ion binding]; other site 205918005677 CDP-binding sites; other site 205918005678 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 205918005679 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 205918005680 Permutation of conserved domain; other site 205918005681 active site 205918005682 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 205918005683 Survival protein SurE; Region: SurE; cl00448 205918005684 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 205918005685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918005686 S-adenosylmethionine binding site [chemical binding]; other site 205918005687 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 205918005688 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918005689 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 205918005690 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 205918005691 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918005692 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 205918005693 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918005694 DNA binding residues [nucleotide binding] 205918005695 Ferredoxin [Energy production and conversion]; Region: COG1146 205918005696 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 205918005697 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 205918005698 MutS domain I; Region: MutS_I; pfam01624 205918005699 MutS domain II; Region: MutS_II; pfam05188 205918005700 MutS family domain IV; Region: MutS_IV; pfam05190 205918005701 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 205918005702 Walker A/P-loop; other site 205918005703 ATP binding site [chemical binding]; other site 205918005704 Q-loop/lid; other site 205918005705 ABC transporter signature motif; other site 205918005706 Walker B; other site 205918005707 D-loop; other site 205918005708 H-loop/switch region; other site 205918005709 Competence-damaged protein; Region: CinA; cl00666 205918005710 recombinase A; Provisional; Region: recA; PRK09354 205918005711 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 205918005712 hexamer interface [polypeptide binding]; other site 205918005713 Walker A motif; other site 205918005714 ATP binding site [chemical binding]; other site 205918005715 Walker B motif; other site 205918005716 RecX family; Region: RecX; cl00936 205918005717 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 205918005718 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 205918005719 DTW domain; Region: DTW; cl01221 205918005720 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918005721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918005722 active site 205918005723 phosphorylation site [posttranslational modification] 205918005724 intermolecular recognition site; other site 205918005725 dimerization interface [polypeptide binding]; other site 205918005726 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918005727 DNA binding residues [nucleotide binding] 205918005728 dimerization interface [polypeptide binding]; other site 205918005729 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 205918005730 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005731 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005732 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005733 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 205918005734 Helix-turn-helix domains; Region: HTH; cl00088 205918005735 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 205918005736 putative dimerization interface [polypeptide binding]; other site 205918005737 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 205918005738 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 205918005739 FAD binding pocket [chemical binding]; other site 205918005740 FAD binding motif [chemical binding]; other site 205918005741 phosphate binding motif [ion binding]; other site 205918005742 beta-alpha-beta structure motif; other site 205918005743 NAD binding pocket [chemical binding]; other site 205918005744 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 205918005745 homodimer interaction site [polypeptide binding]; other site 205918005746 cofactor binding site; other site 205918005747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 205918005748 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 205918005749 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 205918005750 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 205918005751 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205918005752 RNA binding surface [nucleotide binding]; other site 205918005753 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 205918005754 active site 205918005755 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918005756 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918005757 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 205918005758 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 205918005759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918005760 FeS/SAM binding site; other site 205918005761 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 205918005762 putative heme binding pocket [chemical binding]; other site 205918005763 K+ potassium transporter; Region: K_trans; cl15781 205918005764 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005765 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005766 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005767 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005768 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005769 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005770 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005771 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005772 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005773 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005774 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005775 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918005776 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 205918005777 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 205918005778 1 probable transmembrane helix predicted by TMHMM2.0 205918005779 Predicted integral membrane protein [Function unknown]; Region: COG0392 205918005780 Uncharacterized conserved protein [Function unknown]; Region: COG2898 205918005781 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 205918005782 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005783 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005784 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005785 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005786 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005787 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005788 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005789 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005790 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005791 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005792 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005793 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005794 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005795 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918005796 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 205918005797 active site 205918005798 DNA polymerase IV; Validated; Region: PRK02406 205918005799 DNA binding site [nucleotide binding] 205918005800 prolyl-tRNA synthetase; Provisional; Region: PRK09194 205918005801 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 205918005802 dimer interface [polypeptide binding]; other site 205918005803 motif 1; other site 205918005804 active site 205918005805 motif 2; other site 205918005806 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 205918005807 putative deacylase active site [active] 205918005808 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 205918005809 active site 205918005810 motif 3; other site 205918005811 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 205918005812 anticodon binding site; other site 205918005813 outer membrane porin, OprD family; Region: OprD; pfam03573 205918005814 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 205918005815 nucleotide binding site/active site [active] 205918005816 HIT family signature motif; other site 205918005817 catalytic residue [active] 205918005818 SlyX; Region: SlyX; cl01090 205918005819 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 205918005820 DNA-binding site [nucleotide binding]; DNA binding site 205918005821 RNA-binding motif; other site 205918005822 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 205918005823 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 205918005824 dimerization interface [polypeptide binding]; other site 205918005825 DPS ferroxidase diiron center [ion binding]; other site 205918005826 ion pore; other site 205918005827 Ribbon-helix-helix domain; Region: RHH_4; cl01775 205918005828 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 205918005829 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 205918005830 dimer interface [polypeptide binding]; other site 205918005831 anticodon binding site; other site 205918005832 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 205918005833 homodimer interface [polypeptide binding]; other site 205918005834 motif 1; other site 205918005835 active site 205918005836 motif 2; other site 205918005837 GAD domain; Region: GAD; pfam02938 205918005838 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 205918005839 active site 205918005840 motif 3; other site 205918005841 Transcriptional regulator; Region: Transcrip_reg; cl00361 205918005842 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 205918005843 active site 205918005844 putative DNA-binding cleft [nucleotide binding]; other site 205918005845 dimer interface [polypeptide binding]; other site 205918005846 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 205918005847 RuvA N terminal domain; Region: RuvA_N; pfam01330 205918005848 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 205918005849 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 205918005850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918005851 Walker A motif; other site 205918005852 ATP binding site [chemical binding]; other site 205918005853 Walker B motif; other site 205918005854 arginine finger; other site 205918005855 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 205918005856 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 205918005857 active site 205918005858 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 205918005859 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005860 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005861 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005862 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 205918005863 1 probable transmembrane helix predicted by TMHMM2.0 205918005864 TolA protein; Region: tolA_full; TIGR02794 205918005865 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 205918005866 Gram-negative bacterial tonB protein; Region: TonB; cl10048 205918005867 1 probable transmembrane helix predicted by TMHMM2.0 205918005868 translocation protein TolB; Provisional; Region: tolB; PRK00178 205918005869 TolB amino-terminal domain; Region: TolB_N; cl00639 205918005870 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 205918005871 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 205918005872 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 205918005873 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918005874 ligand binding site [chemical binding]; other site 205918005875 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 205918005876 Tetratricopeptide repeat; Region: TPR_6; pfam13174 205918005877 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 205918005878 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918005879 FeS/SAM binding site; other site 205918005880 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 205918005881 Ligand Binding Site [chemical binding]; other site 205918005882 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918005883 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918005884 Q-loop/lid; other site 205918005885 ABC transporter signature motif; other site 205918005886 Walker B; other site 205918005887 D-loop; other site 205918005888 H-loop/switch region; other site 205918005889 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 205918005890 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 205918005891 active site 205918005892 catalytic residues [active] 205918005893 DNA binding site [nucleotide binding] 205918005894 Int/Topo IB signature motif; other site 205918005895 Putative helicase; Region: TraI_2; pfam07514 205918005896 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 205918005897 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 205918005898 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 205918005899 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918005900 Catalytic site [active] 205918005901 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 205918005902 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 205918005903 active site 205918005904 DNA binding site [nucleotide binding] 205918005905 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 205918005906 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 205918005907 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918005908 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918005909 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918005910 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918005911 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918005912 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005913 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005914 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 205918005915 TraU protein; Region: TraU; cl06067 205918005916 Protein of unknown function (DUF1525); Region: DUF1525; cl06515 205918005917 AZL_007950 family protein; Region: AZL_007950_fam; TIGR04061 205918005918 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 205918005919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918005920 cofactor binding site; other site 205918005921 DNA binding site [nucleotide binding] 205918005922 substrate interaction site [chemical binding]; other site 205918005923 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 205918005924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918005925 Helix-turn-helix domains; Region: HTH; cl00088 205918005926 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918005927 putative effector binding pocket; other site 205918005928 dimerization interface [polypeptide binding]; other site 205918005929 Major royal jelly protein; Region: MRJP; pfam03022 205918005930 Helix-turn-helix domains; Region: HTH; cl00088 205918005931 transcriptional activator TtdR; Provisional; Region: PRK09801 205918005932 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918005933 putative effector binding pocket; other site 205918005934 dimerization interface [polypeptide binding]; other site 205918005935 ISPpu14, transposase Orf3 205918005936 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918005937 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 205918005938 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 205918005939 catalytic residues [active] 205918005940 1 probable transmembrane helix predicted by TMHMM2.0 205918005941 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 205918005942 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 205918005943 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 205918005944 Protein of unknown function (DUF972); Region: DUF972; pfam06156 205918005945 1 probable transmembrane helix predicted by TMHMM2.0 205918005946 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 205918005947 Protein of unknown function (DUF2895); Region: DUF2895; cl12968 205918005948 1 probable transmembrane helix predicted by TMHMM2.0 205918005949 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 205918005950 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005951 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005952 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 205918005953 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005954 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005955 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005956 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 205918005957 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005958 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918005959 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 205918005960 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 205918005961 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 205918005962 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 205918005963 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 205918005964 Family description; Region: UvrD_C_2; cl15862 205918005965 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 205918005966 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005967 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005968 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918005969 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 205918005970 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 205918005971 1 probable transmembrane helix predicted by TMHMM2.0 205918005972 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 205918005973 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 205918005974 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 205918005975 1 probable transmembrane helix predicted by TMHMM2.0 205918005976 Cupin superfamily protein; Region: Cupin_4; pfam08007 205918005977 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005978 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005979 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005980 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005981 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005982 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005983 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005984 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005985 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005986 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918005987 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205918005988 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918005989 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 205918005990 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 205918005991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918005992 nucleotide binding region [chemical binding]; other site 205918005993 ATP-binding site [chemical binding]; other site 205918005994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918005995 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 205918005996 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 205918005997 DNA topoisomerase III; Provisional; Region: PRK07726 205918005998 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 205918005999 active site 205918006000 putative interdomain interaction site [polypeptide binding]; other site 205918006001 putative metal-binding site [ion binding]; other site 205918006002 putative nucleotide binding site [chemical binding]; other site 205918006003 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 205918006004 domain I; other site 205918006005 DNA binding groove [nucleotide binding] 205918006006 phosphate binding site [ion binding]; other site 205918006007 domain II; other site 205918006008 domain III; other site 205918006009 nucleotide binding site [chemical binding]; other site 205918006010 catalytic site [active] 205918006011 domain IV; other site 205918006012 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 205918006013 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205918006014 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918006015 active site 205918006016 DNA binding site [nucleotide binding] 205918006017 Int/Topo IB signature motif; other site 205918006018 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 205918006019 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 205918006020 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 205918006021 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 205918006022 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 205918006023 1 probable transmembrane helix predicted by TMHMM2.0 205918006024 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 205918006025 Helix-turn-helix domains; Region: HTH; cl00088 205918006026 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 205918006027 putative dimerization interface [polypeptide binding]; other site 205918006028 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 205918006029 gating phenylalanine in ion channel; other site 205918006030 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006031 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006032 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006033 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006034 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006035 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006036 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006037 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006038 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006039 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006040 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 205918006041 putative uracil binding site [chemical binding]; other site 205918006042 putative active site [active] 205918006043 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 205918006044 dimer interface [polypeptide binding]; other site 205918006045 substrate binding site [chemical binding]; other site 205918006046 metal binding sites [ion binding]; metal-binding site 205918006047 enolase; Provisional; Region: eno; PRK00077 205918006048 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 205918006049 dimer interface [polypeptide binding]; other site 205918006050 metal binding site [ion binding]; metal-binding site 205918006051 substrate binding pocket [chemical binding]; other site 205918006052 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 205918006053 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 205918006054 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 205918006055 putative Cl- selectivity filter; other site 205918006056 putative pore gating glutamate residue; other site 205918006057 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006058 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006059 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006060 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006061 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006062 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006063 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006064 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006065 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918006066 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 205918006067 Membrane transport protein; Region: Mem_trans; cl09117 205918006068 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006069 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006070 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006071 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006072 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006073 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006074 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006075 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006076 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 205918006077 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918006078 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918006079 dimerization interface [polypeptide binding]; other site 205918006080 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918006081 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918006082 dimer interface [polypeptide binding]; other site 205918006083 putative CheW interface [polypeptide binding]; other site 205918006084 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006085 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006086 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205918006087 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918006088 active site 205918006089 DNA binding site [nucleotide binding] 205918006090 Int/Topo IB signature motif; other site 205918006091 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 205918006092 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 205918006093 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 205918006094 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 205918006095 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 205918006096 multicopper oxidase; Provisional; Region: PRK10965 205918006097 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 205918006098 1 probable transmembrane helix predicted by TMHMM2.0 205918006099 Bacterial Ig-like domain; Region: Big_5; cl01012 205918006100 Copper resistance protein D; Region: CopD; cl00563 205918006101 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006102 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006103 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006104 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006105 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006106 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006107 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006108 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006109 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 205918006110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918006111 active site 205918006112 phosphorylation site [posttranslational modification] 205918006113 intermolecular recognition site; other site 205918006114 dimerization interface [polypeptide binding]; other site 205918006115 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918006116 DNA binding site [nucleotide binding] 205918006117 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 205918006118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918006119 dimerization interface [polypeptide binding]; other site 205918006120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918006121 dimer interface [polypeptide binding]; other site 205918006122 phosphorylation site [posttranslational modification] 205918006123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918006124 ATP binding site [chemical binding]; other site 205918006125 Mg2+ binding site [ion binding]; other site 205918006126 G-X-G motif; other site 205918006127 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006128 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006129 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006130 Protein of unknown function, DUF; Region: DUF411; cl01142 205918006131 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 205918006132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918006133 Coenzyme A binding pocket [chemical binding]; other site 205918006134 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 205918006135 Low molecular weight phosphatase family; Region: LMWPc; cl00105 205918006136 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 205918006137 active site 205918006138 arsenical pump membrane protein; Provisional; Region: PRK15445 205918006139 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 205918006140 transmembrane helices; other site 205918006141 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006142 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006143 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006144 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006145 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006146 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006147 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006148 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006149 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006150 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006151 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006152 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918006153 dimerization interface [polypeptide binding]; other site 205918006154 putative DNA binding site [nucleotide binding]; other site 205918006155 putative Zn2+ binding site [ion binding]; other site 205918006156 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 205918006157 putative metal binding site [ion binding]; other site 205918006158 putative homodimer interface [polypeptide binding]; other site 205918006159 putative homotetramer interface [polypeptide binding]; other site 205918006160 putative homodimer-homodimer interface [polypeptide binding]; other site 205918006161 putative allosteric switch controlling residues; other site 205918006162 Cation efflux family; Region: Cation_efflux; cl00316 205918006163 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006164 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006165 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006166 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006167 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006168 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006169 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918006170 active site 205918006171 DNA binding site [nucleotide binding] 205918006172 Int/Topo IB signature motif; other site 205918006173 PilM; Region: PilM; pfam07419 205918006174 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 205918006175 1 probable transmembrane helix predicted by TMHMM2.0 205918006176 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918006177 Walker A motif; other site 205918006178 ATP binding site [chemical binding]; other site 205918006179 Walker B motif; other site 205918006180 PilS N terminal; Region: PilS; pfam08805 205918006181 1 probable transmembrane helix predicted by TMHMM2.0 205918006182 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 205918006183 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 205918006184 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006185 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006186 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006187 Type II/IV secretion system protein; Region: T2SE; pfam00437 205918006188 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918006189 Walker A motif; other site 205918006190 ATP binding site [chemical binding]; other site 205918006191 Walker B motif; other site 205918006192 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 205918006193 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 205918006194 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 205918006195 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 205918006196 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 205918006197 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 205918006198 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 205918006199 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 205918006200 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 205918006201 SEC-C motif; Region: SEC-C; pfam02810 205918006202 DEAD-like helicases superfamily; Region: DEXDc; smart00487 205918006203 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918006204 ATP binding site [chemical binding]; other site 205918006205 putative Mg++ binding site [ion binding]; other site 205918006206 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918006207 nucleotide binding region [chemical binding]; other site 205918006208 ATP-binding site [chemical binding]; other site 205918006209 1 probable transmembrane helix predicted by TMHMM2.0 205918006210 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 205918006211 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 205918006212 ssDNA binding site [nucleotide binding]; other site 205918006213 dimer interface [polypeptide binding]; other site 205918006214 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205918006215 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 205918006216 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 205918006217 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 205918006218 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 205918006219 ParB-like nuclease domain; Region: ParBc; cl02129 205918006220 Arc-like DNA binding domain; Region: Arc; pfam03869 205918006221 replicative DNA helicase; Region: DnaB; TIGR00665 205918006222 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 205918006223 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 205918006224 Walker A motif; other site 205918006225 ATP binding site [chemical binding]; other site 205918006226 Walker B motif; other site 205918006227 DNA binding loops [nucleotide binding] 205918006228 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 205918006229 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205918006230 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918006231 P-loop; other site 205918006232 Magnesium ion binding site [ion binding]; other site 205918006233 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918006234 Magnesium ion binding site [ion binding]; other site 205918006235 hypothetical protein 205918006236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918006237 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 205918006238 indole acetimide hydrolase; Validated; Region: PRK07488 205918006239 Amidase; Region: Amidase; cl11426 205918006240 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 205918006241 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 205918006242 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918006243 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918006244 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918006245 dimer interface [polypeptide binding]; other site 205918006246 putative CheW interface [polypeptide binding]; other site 205918006247 1 probable transmembrane helix predicted by TMHMM2.0 205918006248 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 205918006249 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006250 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006251 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006252 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006253 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006254 Quinolinate synthetase A protein; Region: NadA; cl00420 205918006255 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 205918006256 Peptidase family M48; Region: Peptidase_M48; cl12018 205918006257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 205918006258 binding surface 205918006259 TPR motif; other site 205918006260 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 205918006261 CPxP motif; other site 205918006262 Domain of unknown function DUF20; Region: UPF0118; pfam01594 205918006263 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006264 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006265 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006266 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006267 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006268 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006269 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006270 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 205918006271 catalytic triad [active] 205918006272 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 205918006273 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 205918006274 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 205918006275 dihydrodipicolinate synthase; Region: dapA; TIGR00674 205918006276 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 205918006277 dimer interface [polypeptide binding]; other site 205918006278 active site 205918006279 catalytic residue [active] 205918006280 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 205918006281 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 205918006282 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 205918006283 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 205918006284 ATP binding site [chemical binding]; other site 205918006285 active site 205918006286 substrate binding site [chemical binding]; other site 205918006287 site-specific recombinase, phage integrase family 205918006288 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006289 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006290 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006291 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006292 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006293 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006294 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205918006295 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918006296 P-loop; other site 205918006297 Magnesium ion binding site [ion binding]; other site 205918006298 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918006299 Magnesium ion binding site [ion binding]; other site 205918006300 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 205918006301 FMN binding site [chemical binding]; other site 205918006302 active site 205918006303 substrate binding site [chemical binding]; other site 205918006304 catalytic residue [active] 205918006305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918006306 Helix-turn-helix domains; Region: HTH; cl00088 205918006307 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 205918006308 putative effector binding pocket; other site 205918006309 putative dimerization interface [polypeptide binding]; other site 205918006310 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 205918006311 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 205918006312 malate dehydrogenase; Provisional; Region: PRK13529 205918006313 Malic enzyme, N-terminal domain; Region: malic; pfam00390 205918006314 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 205918006315 NAD(P) binding site [chemical binding]; other site 205918006316 putative metal dependent hydrolase; Provisional; Region: PRK11598 205918006317 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 205918006318 Sulfatase; Region: Sulfatase; cl10460 205918006319 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006320 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006321 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006322 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006323 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006324 ribonuclease D; Region: rnd; TIGR01388 205918006325 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 205918006326 catalytic site [active] 205918006327 putative active site [active] 205918006328 putative substrate binding site [chemical binding]; other site 205918006329 HRDC domain; Region: HRDC; cl02578 205918006330 YcgL domain; Region: YcgL; cl01189 205918006331 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 205918006332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918006333 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 205918006334 putative FMN binding site [chemical binding]; other site 205918006335 Flagellin N-methylase; Region: FliB; cl00497 205918006336 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 205918006337 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 205918006338 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 205918006339 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 205918006340 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 205918006341 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 205918006342 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 205918006343 hypothetical protein; Provisional; Region: PRK11295 205918006344 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 205918006345 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 205918006346 ligand binding site [chemical binding]; other site 205918006347 flexible hinge region; other site 205918006348 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 205918006349 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918006350 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006351 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006352 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 205918006353 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 205918006354 putative active site [active] 205918006355 putative dimer interface [polypeptide binding]; other site 205918006356 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 205918006357 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006358 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006359 WbqC-like protein family; Region: WbqC; pfam08889 205918006360 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 205918006361 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205918006362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918006363 Walker A motif; other site 205918006364 ATP binding site [chemical binding]; other site 205918006365 Walker B motif; other site 205918006366 arginine finger; other site 205918006367 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 205918006368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 205918006369 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 205918006370 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 205918006371 1 probable transmembrane helix predicted by TMHMM2.0 205918006372 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 205918006373 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 205918006374 dimer interface [polypeptide binding]; other site 205918006375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918006376 catalytic residue [active] 205918006377 Cupin domain; Region: Cupin_2; cl09118 205918006378 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006379 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006380 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 205918006381 Na binding site [ion binding]; other site 205918006382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918006383 PAS fold; Region: PAS_7; pfam12860 205918006384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918006385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918006386 dimer interface [polypeptide binding]; other site 205918006387 phosphorylation site [posttranslational modification] 205918006388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918006389 ATP binding site [chemical binding]; other site 205918006390 Mg2+ binding site [ion binding]; other site 205918006391 G-X-G motif; other site 205918006392 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918006393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918006394 active site 205918006395 phosphorylation site [posttranslational modification] 205918006396 intermolecular recognition site; other site 205918006397 dimerization interface [polypeptide binding]; other site 205918006398 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006399 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006400 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006401 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006402 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006403 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006404 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006405 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006406 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006407 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006408 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006409 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006410 H+ Antiporter protein; Region: 2A0121; TIGR00900 205918006411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918006412 putative substrate translocation pore; other site 205918006413 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 205918006414 putative acyl-acceptor binding pocket; other site 205918006415 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006416 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006417 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006418 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006419 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006420 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006421 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006422 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006423 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006424 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006425 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006426 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 205918006427 Membrane transport protein; Region: Mem_trans; cl09117 205918006428 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006429 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006430 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006431 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006432 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006433 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006434 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006435 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918006436 Putative exonuclease, RdgC; Region: RdgC; cl01122 205918006437 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 205918006438 CoA-transferase family III; Region: CoA_transf_3; pfam02515 205918006439 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 205918006440 dimer interface [polypeptide binding]; other site 205918006441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 205918006442 metal binding site [ion binding]; metal-binding site 205918006443 Cupin domain; Region: Cupin_2; cl09118 205918006444 1 probable transmembrane helix predicted by TMHMM2.0 205918006445 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 205918006446 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 205918006447 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 205918006448 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 205918006449 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 205918006450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918006451 non-specific DNA binding site [nucleotide binding]; other site 205918006452 salt bridge; other site 205918006453 sequence-specific DNA binding site [nucleotide binding]; other site 205918006454 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918006455 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 205918006456 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918006457 metal binding site [ion binding]; metal-binding site 205918006458 active site 205918006459 I-site; other site 205918006460 carboxy-terminal protease; Provisional; Region: PRK11186 205918006461 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 205918006462 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 205918006463 protein binding site [polypeptide binding]; other site 205918006464 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 205918006465 Catalytic dyad [active] 205918006466 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 205918006467 1 probable transmembrane helix predicted by TMHMM2.0 205918006468 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 205918006469 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 205918006470 NAD(P) binding site [chemical binding]; other site 205918006471 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 205918006472 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918006473 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205918006474 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918006475 Walker A/P-loop; other site 205918006476 ATP binding site [chemical binding]; other site 205918006477 Q-loop/lid; other site 205918006478 ABC transporter signature motif; other site 205918006479 Walker B; other site 205918006480 D-loop; other site 205918006481 H-loop/switch region; other site 205918006482 TOBE domain; Region: TOBE_2; cl01440 205918006483 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205918006484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918006485 dimer interface [polypeptide binding]; other site 205918006486 conserved gate region; other site 205918006487 putative PBP binding loops; other site 205918006488 ABC-ATPase subunit interface; other site 205918006489 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006490 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006491 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006492 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006493 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006494 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006495 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918006496 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 205918006497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918006498 dimer interface [polypeptide binding]; other site 205918006499 conserved gate region; other site 205918006500 putative PBP binding loops; other site 205918006501 ABC-ATPase subunit interface; other site 205918006502 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006503 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006504 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006505 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006506 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006507 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006508 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 205918006509 PglZ domain; Region: PglZ; pfam08665 205918006510 Sulfatase; Region: Sulfatase; cl10460 205918006511 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918006512 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205918006513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918006514 transcriptional regulator protein; Region: phnR; TIGR03337 205918006515 DNA-binding site [nucleotide binding]; DNA binding site 205918006516 UTRA domain; Region: UTRA; cl01230 205918006517 hypothetical protein; Provisional; Region: PRK09946 205918006518 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 205918006519 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 205918006520 active site 205918006521 metal binding site [ion binding]; metal-binding site 205918006522 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 205918006523 active site 205918006524 Septum formation topological specificity factor MinE; Region: MinE; cl00538 205918006525 cell division inhibitor MinD; Provisional; Region: PRK10818 205918006526 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 205918006527 Switch I; other site 205918006528 Switch II; other site 205918006529 septum formation inhibitor; Reviewed; Region: minC; PRK00339 205918006530 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 205918006531 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 205918006532 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 205918006533 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 205918006534 putative acyl-acceptor binding pocket; other site 205918006535 1 probable transmembrane helix predicted by TMHMM2.0 205918006536 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 205918006537 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 205918006538 active site 205918006539 nucleophile elbow; other site 205918006540 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 205918006541 iron-sulfur cluster [ion binding]; other site 205918006542 [2Fe-2S] cluster binding site [ion binding]; other site 205918006543 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 205918006544 inhibitor site; inhibition site 205918006545 active site 205918006546 dimer interface [polypeptide binding]; other site 205918006547 catalytic residue [active] 205918006548 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205918006549 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918006550 catalytic residue [active] 205918006551 Autoinducer synthetase; Region: Autoind_synth; pfam00765 205918006552 Autoinducer binding domain; Region: Autoind_bind; pfam03472 205918006553 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918006554 DNA binding residues [nucleotide binding] 205918006555 dimerization interface [polypeptide binding]; other site 205918006556 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 205918006557 Helix-turn-helix domains; Region: HTH; cl00088 205918006558 Transcriptional regulators [Transcription]; Region: MarR; COG1846 205918006559 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 205918006560 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 205918006561 dimer interface [polypeptide binding]; other site 205918006562 TPP-binding site [chemical binding]; other site 205918006563 Pirin-related protein [General function prediction only]; Region: COG1741 205918006564 Cupin domain; Region: Cupin_2; cl09118 205918006565 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 205918006566 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 205918006567 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 205918006568 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 205918006569 active site 205918006570 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 205918006571 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006572 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006573 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006574 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918006575 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 205918006576 putative C-terminal domain interface [polypeptide binding]; other site 205918006577 putative GSH binding site (G-site) [chemical binding]; other site 205918006578 putative dimer interface [polypeptide binding]; other site 205918006579 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 205918006580 putative N-terminal domain interface [polypeptide binding]; other site 205918006581 putative dimer interface [polypeptide binding]; other site 205918006582 putative substrate binding pocket (H-site) [chemical binding]; other site 205918006583 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 205918006584 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918006585 Walker A/P-loop; other site 205918006586 ATP binding site [chemical binding]; other site 205918006587 Q-loop/lid; other site 205918006588 ABC transporter signature motif; other site 205918006589 Walker B; other site 205918006590 D-loop; other site 205918006591 H-loop/switch region; other site 205918006592 ABC-2 type transporter; Region: ABC2_membrane; cl11417 205918006593 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006594 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006595 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006596 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006597 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006598 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006599 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 205918006600 Competence protein; Region: Competence; cl00471 205918006601 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 205918006602 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006603 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006604 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006605 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006606 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006607 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006608 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006609 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006610 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006611 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006612 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 205918006613 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006614 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006615 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006616 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 205918006617 1 probable transmembrane helix predicted by TMHMM2.0 205918006618 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 205918006619 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 205918006620 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 205918006621 Ligand binding site; other site 205918006622 oligomer interface; other site 205918006623 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 205918006624 FAD binding domain; Region: FAD_binding_4; pfam01565 205918006625 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 205918006626 ribonuclease E; Reviewed; Region: rne; PRK10811 205918006627 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 205918006628 homodimer interface [polypeptide binding]; other site 205918006629 oligonucleotide binding site [chemical binding]; other site 205918006630 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 205918006631 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 205918006632 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 205918006633 active site 205918006634 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 205918006635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918006636 motif II; other site 205918006637 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 205918006638 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 205918006639 tandem repeat interface [polypeptide binding]; other site 205918006640 oligomer interface [polypeptide binding]; other site 205918006641 active site residues [active] 205918006642 1 probable transmembrane helix predicted by TMHMM2.0 205918006643 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 205918006644 active site 205918006645 dimer interface [polypeptide binding]; other site 205918006646 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 205918006647 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 205918006648 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 205918006649 Acyl transferase domain; Region: Acyl_transf_1; cl08282 205918006650 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 205918006651 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 205918006652 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 205918006653 NAD(P) binding site [chemical binding]; other site 205918006654 homotetramer interface [polypeptide binding]; other site 205918006655 homodimer interface [polypeptide binding]; other site 205918006656 active site 205918006657 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918006658 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 205918006659 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 205918006660 dimer interface [polypeptide binding]; other site 205918006661 active site 205918006662 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 205918006663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918006664 catalytic residue [active] 205918006665 YceG-like family; Region: YceG; pfam02618 205918006666 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 205918006667 dimerization interface [polypeptide binding]; other site 205918006668 thymidylate kinase; Validated; Region: tmk; PRK00698 205918006669 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 205918006670 TMP-binding site; other site 205918006671 ATP-binding site [chemical binding]; other site 205918006672 DNA polymerase III subunit delta'; Validated; Region: PRK05707 205918006673 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918006674 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918006675 PilZ domain; Region: PilZ; cl01260 205918006676 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 205918006677 active site 205918006678 LysE type translocator; Region: LysE; cl00565 205918006679 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006680 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006681 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006682 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006683 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006684 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918006686 Helix-turn-helix domains; Region: HTH; cl00088 205918006687 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 205918006688 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 205918006689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918006690 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 205918006691 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 205918006692 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 205918006693 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 205918006694 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 205918006695 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 205918006696 1 probable transmembrane helix predicted by TMHMM2.0 205918006697 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 205918006698 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 205918006699 dimerization interface 3.5A [polypeptide binding]; other site 205918006700 active site 205918006701 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 205918006702 active site 205918006703 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 205918006704 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 205918006705 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 205918006706 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205918006707 Sporulation related domain; Region: SPOR; cl10051 205918006708 1 probable transmembrane helix predicted by TMHMM2.0 205918006709 Colicin V production protein; Region: Colicin_V; cl00567 205918006710 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006711 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006712 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006713 amidophosphoribosyltransferase; Provisional; Region: PRK09246 205918006714 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 205918006715 active site 205918006716 tetramer interface [polypeptide binding]; other site 205918006717 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918006718 active site 205918006719 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 205918006720 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 205918006721 homodimer interface [polypeptide binding]; other site 205918006722 substrate-cofactor binding pocket; other site 205918006723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918006724 catalytic residue [active] 205918006725 oxidoreductase; Validated; Region: PRK05717 205918006726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918006727 NAD(P) binding site [chemical binding]; other site 205918006728 active site 205918006729 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 205918006730 threonine dehydratase; Reviewed; Region: PRK09224 205918006731 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 205918006732 tetramer interface [polypeptide binding]; other site 205918006733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918006734 catalytic residue [active] 205918006735 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 205918006736 putative Ile/Val binding site [chemical binding]; other site 205918006737 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 205918006738 putative Ile/Val binding site [chemical binding]; other site 205918006739 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 205918006740 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918006741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918006742 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 205918006743 active site 205918006744 catalytic triad [active] 205918006745 dimer interface [polypeptide binding]; other site 205918006746 1 probable transmembrane helix predicted by TMHMM2.0 205918006747 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 205918006748 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 205918006749 active site 205918006750 FMN binding site [chemical binding]; other site 205918006751 2,4-decadienoyl-CoA binding site; other site 205918006752 catalytic residue [active] 205918006753 4Fe-4S cluster binding site [ion binding]; other site 205918006754 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 205918006755 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 205918006756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918006757 metabolite-proton symporter; Region: 2A0106; TIGR00883 205918006758 putative substrate translocation pore; other site 205918006759 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006760 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006761 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006762 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006763 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006764 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006765 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006766 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006767 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006768 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006769 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006770 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918006772 putative substrate translocation pore; other site 205918006773 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006774 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006775 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006776 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006777 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006778 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006779 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006780 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006781 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006782 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006783 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006784 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006785 arsenical pump membrane protein; Provisional; Region: PRK15445 205918006786 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 205918006787 transmembrane helices; other site 205918006788 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006789 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006790 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006791 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006792 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006793 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006794 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006795 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006796 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006797 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006798 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918006799 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 205918006800 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918006801 metal binding site [ion binding]; metal-binding site 205918006802 active site 205918006803 I-site; other site 205918006804 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006805 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006806 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006807 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006808 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006809 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006810 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 205918006811 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 205918006812 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205918006813 active site 205918006814 metal binding site [ion binding]; metal-binding site 205918006815 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 205918006816 Rhomboid family; Region: Rhomboid; cl11446 205918006817 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006818 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006819 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006820 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006821 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006822 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006823 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 205918006824 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 205918006825 aminopeptidase N; Provisional; Region: pepN; PRK14015 205918006826 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 205918006827 active site 205918006828 Zn binding site [ion binding]; other site 205918006829 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 205918006830 PspA/IM30 family; Region: PspA_IM30; pfam04012 205918006831 Rhomboid family; Region: Rhomboid; cl11446 205918006832 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006833 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006834 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006835 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006836 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006837 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918006838 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 205918006839 Predicted membrane protein [Function unknown]; Region: COG3766 205918006840 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 205918006841 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918006842 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918006843 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918006844 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918006845 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 205918006846 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503 205918006847 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 205918006848 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 205918006849 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 205918006850 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006851 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006852 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006853 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006854 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006855 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006856 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006857 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006858 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006859 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006860 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006861 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006862 transcriptional regulator NarP; Provisional; Region: PRK10403 205918006863 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918006864 DNA binding residues [nucleotide binding] 205918006865 dimerization interface [polypeptide binding]; other site 205918006866 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 205918006867 Fatty acid desaturase; Region: FA_desaturase; pfam00487 205918006868 putative di-iron ligands [ion binding]; other site 205918006869 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 205918006870 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006871 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006872 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918006873 peptide synthase; Provisional; Region: PRK12467 205918006874 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918006875 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918006876 AMP-binding enzyme; Region: AMP-binding; cl15778 205918006877 AMP-binding enzyme; Region: AMP-binding; cl15778 205918006878 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918006879 peptide synthase; Provisional; Region: PRK12467 205918006880 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918006881 AMP-binding enzyme; Region: AMP-binding; cl15778 205918006882 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918006883 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918006884 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918006885 AMP-binding enzyme; Region: AMP-binding; cl15778 205918006886 acyl-CoA synthetase; Validated; Region: PRK08308 205918006887 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918006888 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 205918006889 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918006890 active site 205918006891 Acyl transferase domain; Region: Acyl_transf_1; cl08282 205918006892 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 205918006893 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 205918006894 putative NADP binding site [chemical binding]; other site 205918006895 active site 205918006896 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 205918006897 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918006898 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918006899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 205918006900 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006901 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006902 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006903 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006904 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006905 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006906 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006907 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006908 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006909 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918006910 Transcriptional regulators [Transcription]; Region: FadR; COG2186 205918006911 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918006912 DNA-binding site [nucleotide binding]; DNA binding site 205918006913 FCD domain; Region: FCD; cl11656 205918006914 Dehydratase family; Region: ILVD_EDD; cl00340 205918006915 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 205918006916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918006917 putative substrate translocation pore; other site 205918006918 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006919 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006920 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006921 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006922 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006923 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006924 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006925 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006926 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006927 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006928 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006929 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918006930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 205918006931 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 205918006932 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 205918006933 exonuclease subunit SbcC; Provisional; Region: PRK10246 205918006934 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918006935 Walker A/P-loop; other site 205918006936 ATP binding site [chemical binding]; other site 205918006937 Q-loop/lid; other site 205918006938 exonuclease subunit SbcC; Provisional; Region: PRK10246 205918006939 exonuclease subunit SbcC; Provisional; Region: PRK10246 205918006940 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918006941 ABC transporter signature motif; other site 205918006942 Walker B; other site 205918006943 D-loop; other site 205918006944 H-loop/switch region; other site 205918006945 exonuclease subunit SbcD; Provisional; Region: PRK10966 205918006946 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 205918006947 active site 205918006948 metal binding site [ion binding]; metal-binding site 205918006949 DNA binding site [nucleotide binding] 205918006950 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 205918006951 Oxygen tolerance; Region: BatD; pfam13584 205918006952 1 probable transmembrane helix predicted by TMHMM2.0 205918006953 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 205918006954 metal ion-dependent adhesion site (MIDAS); other site 205918006955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918006956 TPR motif; other site 205918006957 binding surface 205918006958 TPR repeat; Region: TPR_11; pfam13414 205918006959 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006960 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918006961 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 205918006962 metal ion-dependent adhesion site (MIDAS); other site 205918006963 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 205918006964 1 probable transmembrane helix predicted by TMHMM2.0 205918006965 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 205918006966 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 205918006967 MoxR-like ATPases [General function prediction only]; Region: COG0714 205918006968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918006969 Walker A motif; other site 205918006970 ATP binding site [chemical binding]; other site 205918006971 Walker B motif; other site 205918006972 arginine finger; other site 205918006973 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 205918006974 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 205918006975 active site 205918006976 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 205918006977 hypothetical protein; Provisional; Region: PRK11469 205918006978 Domain of unknown function DUF; Region: DUF204; pfam02659 205918006979 Domain of unknown function DUF; Region: DUF204; pfam02659 205918006980 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006981 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006982 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006983 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006984 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918006985 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 205918006986 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 205918006987 substrate binding site [chemical binding]; other site 205918006988 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 205918006989 substrate binding site [chemical binding]; other site 205918006990 ligand binding site [chemical binding]; other site 205918006991 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 205918006992 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 205918006993 active site 205918006994 dinuclear metal binding site [ion binding]; other site 205918006995 dimerization interface [polypeptide binding]; other site 205918006996 Helix-turn-helix domains; Region: HTH; cl00088 205918006997 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 205918006998 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 205918006999 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918007000 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918007001 1 probable transmembrane helix predicted by TMHMM2.0 205918007002 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205918007003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918007004 putative substrate translocation pore; other site 205918007005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918007006 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007007 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007008 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007009 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007010 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007011 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007012 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007013 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007014 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007015 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007016 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007017 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007018 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007019 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007020 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 205918007021 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 205918007022 putative active site [active] 205918007023 putative metal binding site [ion binding]; other site 205918007024 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 205918007025 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 205918007026 substrate binding site [chemical binding]; other site 205918007027 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 205918007028 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205918007029 active site 205918007030 HIGH motif; other site 205918007031 nucleotide binding site [chemical binding]; other site 205918007032 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 205918007033 KMSKS motif; other site 205918007034 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 205918007035 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 205918007036 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 205918007037 active site 205918007038 HIGH motif; other site 205918007039 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 205918007040 KMSKS motif; other site 205918007041 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 205918007042 tRNA binding surface [nucleotide binding]; other site 205918007043 anticodon binding site; other site 205918007044 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 205918007045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918007046 Walker A motif; other site 205918007047 ATP binding site [chemical binding]; other site 205918007048 Walker B motif; other site 205918007049 arginine finger; other site 205918007050 Helix-turn-helix domains; Region: HTH; cl00088 205918007051 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 205918007052 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 205918007053 Walker A/P-loop; other site 205918007054 ATP binding site [chemical binding]; other site 205918007055 Q-loop/lid; other site 205918007056 ABC transporter signature motif; other site 205918007057 Walker B; other site 205918007058 D-loop; other site 205918007059 H-loop/switch region; other site 205918007060 TOBE domain; Region: TOBE_2; cl01440 205918007061 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 205918007062 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 205918007063 Walker A/P-loop; other site 205918007064 ATP binding site [chemical binding]; other site 205918007065 Q-loop/lid; other site 205918007066 ABC transporter signature motif; other site 205918007067 Walker B; other site 205918007068 D-loop; other site 205918007069 H-loop/switch region; other site 205918007070 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 205918007071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918007072 dimer interface [polypeptide binding]; other site 205918007073 conserved gate region; other site 205918007074 putative PBP binding loops; other site 205918007075 ABC-ATPase subunit interface; other site 205918007076 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007077 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007078 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007079 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007080 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007081 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007082 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205918007083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918007084 dimer interface [polypeptide binding]; other site 205918007085 conserved gate region; other site 205918007086 putative PBP binding loops; other site 205918007087 ABC-ATPase subunit interface; other site 205918007088 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007089 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007090 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007091 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007092 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007093 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007094 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 205918007095 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007096 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007097 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007098 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205918007099 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 205918007100 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 205918007101 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 205918007102 homodimer interface [polypeptide binding]; other site 205918007103 NADP binding site [chemical binding]; other site 205918007104 substrate binding site [chemical binding]; other site 205918007105 trigger factor; Provisional; Region: tig; PRK01490 205918007106 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 205918007107 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 205918007108 1 probable transmembrane helix predicted by TMHMM2.0 205918007109 Clp protease; Region: CLP_protease; pfam00574 205918007110 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 205918007111 oligomer interface [polypeptide binding]; other site 205918007112 active site residues [active] 205918007113 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 205918007114 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 205918007115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918007116 Walker A motif; other site 205918007117 ATP binding site [chemical binding]; other site 205918007118 Walker B motif; other site 205918007119 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 205918007120 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 205918007121 Found in ATP-dependent protease La (LON); Region: LON; smart00464 205918007122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918007123 Walker A motif; other site 205918007124 ATP binding site [chemical binding]; other site 205918007125 Walker B motif; other site 205918007126 arginine finger; other site 205918007127 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 205918007128 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 205918007129 IHF - DNA interface [nucleotide binding]; other site 205918007130 IHF dimer interface [polypeptide binding]; other site 205918007131 periplasmic folding chaperone; Provisional; Region: PRK10788 205918007132 SurA N-terminal domain; Region: SurA_N_3; cl07813 205918007133 PPIC-type PPIASE domain; Region: Rotamase; cl08278 205918007134 1 probable transmembrane helix predicted by TMHMM2.0 205918007135 Helix-turn-helix domains; Region: HTH; cl00088 205918007136 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 205918007137 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 205918007138 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 205918007139 NAD binding site [chemical binding]; other site 205918007140 homotetramer interface [polypeptide binding]; other site 205918007141 homodimer interface [polypeptide binding]; other site 205918007142 substrate binding site [chemical binding]; other site 205918007143 active site 205918007144 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 205918007145 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918007146 Walker A/P-loop; other site 205918007147 ATP binding site [chemical binding]; other site 205918007148 Q-loop/lid; other site 205918007149 ABC transporter signature motif; other site 205918007150 Walker B; other site 205918007151 D-loop; other site 205918007152 H-loop/switch region; other site 205918007153 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918007154 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918007155 Walker A/P-loop; other site 205918007156 ATP binding site [chemical binding]; other site 205918007157 Q-loop/lid; other site 205918007158 ABC transporter signature motif; other site 205918007159 Walker B; other site 205918007160 D-loop; other site 205918007161 H-loop/switch region; other site 205918007162 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918007163 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 205918007164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918007165 dimer interface [polypeptide binding]; other site 205918007166 conserved gate region; other site 205918007167 putative PBP binding loops; other site 205918007168 ABC-ATPase subunit interface; other site 205918007169 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007170 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007171 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007172 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007173 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007174 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007175 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 205918007176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918007177 dimer interface [polypeptide binding]; other site 205918007178 conserved gate region; other site 205918007179 putative PBP binding loops; other site 205918007180 ABC-ATPase subunit interface; other site 205918007181 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007182 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007183 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007184 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007185 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007186 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007187 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 205918007188 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 205918007189 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 205918007190 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 205918007191 MltD lipid attachment motif; Region: MLTD_N; pfam06474 205918007192 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 205918007193 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 205918007194 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918007195 catalytic residue [active] 205918007196 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918007197 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918007198 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918007199 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 205918007200 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 205918007201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918007202 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 205918007203 RNA/DNA hybrid binding site [nucleotide binding]; other site 205918007204 active site 205918007205 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 205918007206 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 205918007207 active site 205918007208 catalytic site [active] 205918007209 substrate binding site [chemical binding]; other site 205918007210 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205918007211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918007212 Coenzyme A binding pocket [chemical binding]; other site 205918007213 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 205918007214 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918007215 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918007216 active site 205918007217 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 205918007218 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918007219 substrate binding site [chemical binding]; other site 205918007220 oxyanion hole (OAH) forming residues; other site 205918007221 trimer interface [polypeptide binding]; other site 205918007222 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 205918007223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918007224 putative substrate translocation pore; other site 205918007225 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205918007226 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007227 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007228 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007229 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007230 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007231 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007232 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007233 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007234 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007235 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007236 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007237 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007238 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007239 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918007240 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 205918007241 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918007242 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918007243 1 probable transmembrane helix predicted by TMHMM2.0 205918007244 Phosphate transporter family; Region: PHO4; cl00396 205918007245 Phosphate transporter family; Region: PHO4; cl00396 205918007246 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007247 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007248 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007249 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007250 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007251 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007252 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007253 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007254 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007255 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 205918007256 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 205918007257 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007258 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007259 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918007260 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205918007261 active site 205918007262 catalytic tetrad [active] 205918007263 Cache domain; Region: Cache_2; cl07034 205918007264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918007265 dimerization interface [polypeptide binding]; other site 205918007266 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918007267 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918007268 dimer interface [polypeptide binding]; other site 205918007269 putative CheW interface [polypeptide binding]; other site 205918007270 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007271 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007272 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918007273 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 205918007274 Helix-turn-helix domains; Region: HTH; cl00088 205918007275 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 205918007276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918007277 PAS domain; Region: PAS_9; pfam13426 205918007278 putative active site [active] 205918007279 heme pocket [chemical binding]; other site 205918007280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918007281 PAS fold; Region: PAS_3; pfam08447 205918007282 putative active site [active] 205918007283 heme pocket [chemical binding]; other site 205918007284 PAS domain S-box; Region: sensory_box; TIGR00229 205918007285 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918007286 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918007287 PAS fold; Region: PAS_3; pfam08447 205918007288 putative active site [active] 205918007289 heme pocket [chemical binding]; other site 205918007290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918007291 dimer interface [polypeptide binding]; other site 205918007292 phosphorylation site [posttranslational modification] 205918007293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918007294 ATP binding site [chemical binding]; other site 205918007295 Mg2+ binding site [ion binding]; other site 205918007296 G-X-G motif; other site 205918007297 Response regulator receiver domain; Region: Response_reg; pfam00072 205918007298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918007299 active site 205918007300 phosphorylation site [posttranslational modification] 205918007301 intermolecular recognition site; other site 205918007302 dimerization interface [polypeptide binding]; other site 205918007303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918007304 Helix-turn-helix domains; Region: HTH; cl00088 205918007305 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 205918007306 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 205918007307 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 205918007308 PA14 domain; Region: PA14; cl08459 205918007309 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 205918007310 Fibronectin type III-like domain; Region: Fn3-like; cl15273 205918007311 1 probable transmembrane helix predicted by TMHMM2.0 205918007312 hypothetical protein 205918007313 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 205918007314 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918007315 N-terminal plug; other site 205918007316 ligand-binding site [chemical binding]; other site 205918007317 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 205918007318 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 205918007319 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007320 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007321 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007322 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007323 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 205918007324 putative arabinose transporter; Provisional; Region: PRK03545 205918007325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918007326 putative substrate translocation pore; other site 205918007327 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007328 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007329 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007330 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007331 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007332 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007333 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007334 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007335 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007336 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007337 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007338 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007339 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918007340 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918007341 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918007342 dimer interface [polypeptide binding]; other site 205918007343 putative CheW interface [polypeptide binding]; other site 205918007344 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007345 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007346 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 205918007347 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918007348 active site 205918007349 catalytic tetrad [active] 205918007350 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 205918007351 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918007352 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918007353 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 205918007354 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007355 peptide synthase; Validated; Region: PRK05691 205918007356 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918007357 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918007358 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007359 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007360 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918007361 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918007362 Nonribosomal peptide synthase; Region: NRPS; pfam08415 205918007363 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007364 acyl-CoA synthetase; Validated; Region: PRK08308 205918007365 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918007366 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 205918007367 putative FMN binding site [chemical binding]; other site 205918007368 NADPH bind site [chemical binding]; other site 205918007369 peptide synthase; Provisional; Region: PRK12467 205918007370 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918007371 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007372 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918007373 Thioesterase domain; Region: Thioesterase; pfam00975 205918007374 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 205918007375 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007376 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007377 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918007378 peptide synthase; Provisional; Region: PRK12467 205918007379 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918007380 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007381 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918007382 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918007383 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 205918007384 active site 205918007385 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 205918007386 putative NADP binding site [chemical binding]; other site 205918007387 active site 205918007388 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918007389 Thioesterase domain; Region: Thioesterase; pfam00975 205918007390 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 205918007391 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 205918007392 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205918007393 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918007394 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 205918007395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918007396 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918007397 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918007398 dimerization interface [polypeptide binding]; other site 205918007399 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918007400 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918007401 dimer interface [polypeptide binding]; other site 205918007402 putative CheW interface [polypeptide binding]; other site 205918007403 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007404 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007405 EamA-like transporter family; Region: EamA; cl01037 205918007406 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 205918007407 EamA-like transporter family; Region: EamA; cl01037 205918007408 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007409 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007410 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007411 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007412 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007413 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007414 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007415 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007416 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918007417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918007418 Helix-turn-helix domains; Region: HTH; cl00088 205918007419 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918007420 dimerization interface [polypeptide binding]; other site 205918007421 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 205918007422 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 205918007423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918007424 catalytic residue [active] 205918007425 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 205918007426 Helix-turn-helix domains; Region: HTH; cl00088 205918007427 AsnC family; Region: AsnC_trans_reg; pfam01037 205918007428 Protein of unknown function (DUF808); Region: DUF808; cl01002 205918007429 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007430 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007431 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007432 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007433 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007434 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007435 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 205918007436 Predicted membrane protein [Function unknown]; Region: COG3748 205918007437 Protein of unknown function (DUF989); Region: DUF989; pfam06181 205918007438 Cytochrome c; Region: Cytochrom_C; cl11414 205918007439 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007440 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007441 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007442 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007443 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007444 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007445 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007446 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007447 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 205918007448 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 205918007449 allantoicase; Provisional; Region: PRK13257 205918007450 Allantoicase repeat; Region: Allantoicase; pfam03561 205918007451 Allantoicase repeat; Region: Allantoicase; pfam03561 205918007452 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 205918007453 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 205918007454 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 205918007455 active site 205918007456 catalytic site [active] 205918007457 tetramer interface [polypeptide binding]; other site 205918007458 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 205918007459 active site 205918007460 homotetramer interface [polypeptide binding]; other site 205918007461 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918007462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918007463 DNA-binding site [nucleotide binding]; DNA binding site 205918007464 FCD domain; Region: FCD; cl11656 205918007465 guanine deaminase; Provisional; Region: PRK09228 205918007466 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 205918007467 active site 205918007468 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 205918007469 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 205918007470 XdhC Rossmann domain; Region: XdhC_C; pfam13478 205918007471 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 205918007472 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 205918007473 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 205918007474 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 205918007475 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 205918007476 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 205918007477 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 205918007478 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918007479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918007480 DNA-binding site [nucleotide binding]; DNA binding site 205918007481 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205918007482 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 205918007483 Walker A/P-loop; other site 205918007484 ATP binding site [chemical binding]; other site 205918007485 Q-loop/lid; other site 205918007486 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 205918007487 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 205918007488 ABC transporter signature motif; other site 205918007489 Walker B; other site 205918007490 D-loop; other site 205918007491 H-loop/switch region; other site 205918007492 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 205918007493 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 205918007494 FtsZ protein binding site [polypeptide binding]; other site 205918007495 1 probable transmembrane helix predicted by TMHMM2.0 205918007496 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 205918007497 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 205918007498 nucleotide binding pocket [chemical binding]; other site 205918007499 K-X-D-G motif; other site 205918007500 catalytic site [active] 205918007501 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 205918007502 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 205918007503 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 205918007504 Dimer interface [polypeptide binding]; other site 205918007505 BRCT sequence motif; other site 205918007506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 205918007507 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 205918007508 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918007509 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918007510 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007511 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007512 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007513 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007514 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007515 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 205918007516 Phosphoesterase family; Region: Phosphoesterase; cl15450 205918007517 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 205918007518 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918007519 substrate binding pocket [chemical binding]; other site 205918007520 membrane-bound complex binding site; other site 205918007521 hinge residues; other site 205918007522 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 205918007523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918007524 Walker A motif; other site 205918007525 ATP binding site [chemical binding]; other site 205918007526 Walker B motif; other site 205918007527 arginine finger; other site 205918007528 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 205918007529 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 205918007530 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 205918007531 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 205918007532 CPxP motif; other site 205918007533 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 205918007534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918007535 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 205918007536 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 205918007537 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205918007538 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 205918007539 Walker A/P-loop; other site 205918007540 ATP binding site [chemical binding]; other site 205918007541 Q-loop/lid; other site 205918007542 ABC transporter signature motif; other site 205918007543 Walker B; other site 205918007544 D-loop; other site 205918007545 H-loop/switch region; other site 205918007546 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007547 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007548 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007549 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007550 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007551 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918007552 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 205918007553 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 205918007554 active site 205918007555 catalytic site [active] 205918007556 substrate binding site [chemical binding]; other site 205918007557 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918007558 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918007559 substrate binding pocket [chemical binding]; other site 205918007560 membrane-bound complex binding site; other site 205918007561 hinge residues; other site 205918007562 1 probable transmembrane helix predicted by TMHMM2.0 205918007563 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 205918007564 1 probable transmembrane helix predicted by TMHMM2.0 205918007565 ethanolamine permease; Region: 2A0305; TIGR00908 205918007566 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007567 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007568 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007569 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007570 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007571 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007572 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007573 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007574 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007575 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007576 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007577 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007578 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 205918007579 active site 205918007580 dimer interface [polypeptide binding]; other site 205918007581 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 205918007582 Prostaglandin dehydrogenases; Region: PGDH; cd05288 205918007583 NAD(P) binding site [chemical binding]; other site 205918007584 substrate binding site [chemical binding]; other site 205918007585 dimer interface [polypeptide binding]; other site 205918007586 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 205918007587 dimer interface [polypeptide binding]; other site 205918007588 catalytic triad [active] 205918007589 Benzoate membrane transport protein; Region: BenE; pfam03594 205918007590 benzoate transporter; Region: benE; TIGR00843 205918007591 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007592 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007593 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007594 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007595 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007596 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007597 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007598 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007599 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007600 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007601 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007602 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007603 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 205918007604 Helix-turn-helix domains; Region: HTH; cl00088 205918007605 aspartate aminotransferase; Provisional; Region: PRK05764 205918007606 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918007607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918007608 homodimer interface [polypeptide binding]; other site 205918007609 catalytic residue [active] 205918007610 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918007611 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 205918007612 putative C-terminal domain interface [polypeptide binding]; other site 205918007613 putative GSH binding site (G-site) [chemical binding]; other site 205918007614 putative dimer interface [polypeptide binding]; other site 205918007615 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 205918007616 N-terminal domain interface [polypeptide binding]; other site 205918007617 dimer interface [polypeptide binding]; other site 205918007618 substrate binding pocket (H-site) [chemical binding]; other site 205918007619 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 205918007620 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 205918007621 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 205918007622 GTP cyclohydrolase I; Provisional; Region: PLN03044 205918007623 homodecamer interface [polypeptide binding]; other site 205918007624 active site 205918007625 putative catalytic site residues [active] 205918007626 zinc binding site [ion binding]; other site 205918007627 GTP-CH-I/GFRP interaction surface; other site 205918007628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 205918007629 Smr domain; Region: Smr; cl02619 205918007630 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007631 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007632 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 205918007633 Isochorismatase family; Region: Isochorismatase; pfam00857 205918007634 catalytic triad [active] 205918007635 conserved cis-peptide bond; other site 205918007636 HemK family putative methylases; Region: hemK_fam; TIGR00536 205918007637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918007638 S-adenosylmethionine binding site [chemical binding]; other site 205918007639 1 probable transmembrane helix predicted by TMHMM2.0 205918007640 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918007641 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 205918007642 Tetramer interface [polypeptide binding]; other site 205918007643 active site 205918007644 FMN-binding site [chemical binding]; other site 205918007645 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 205918007646 MFS_1 like family; Region: MFS_1_like; pfam12832 205918007647 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007648 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007649 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007650 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007651 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007652 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007653 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007654 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007655 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007656 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007657 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007658 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 205918007659 intersubunit interface [polypeptide binding]; other site 205918007660 active site 205918007661 Zn2+ binding site [ion binding]; other site 205918007662 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 205918007663 Cupin domain; Region: Cupin_2; cl09118 205918007664 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 205918007665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918007666 motif II; other site 205918007667 Autoinducer binding domain; Region: Autoind_bind; pfam03472 205918007668 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918007669 DNA binding residues [nucleotide binding] 205918007670 dimerization interface [polypeptide binding]; other site 205918007671 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 205918007672 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 205918007673 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205918007674 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205918007675 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 205918007676 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007677 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007678 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007679 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007680 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007681 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007682 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918007683 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007684 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007685 spermidine synthase; Provisional; Region: PRK00811 205918007686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918007687 S-adenosylmethionine binding site [chemical binding]; other site 205918007688 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 205918007689 Sulfatase; Region: Sulfatase; cl10460 205918007690 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007691 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007692 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007693 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007694 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918007695 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 205918007696 Uncharacterized conserved protein [Function unknown]; Region: COG2308 205918007697 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 205918007698 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 205918007699 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 205918007700 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 205918007701 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 205918007702 active site residue [active] 205918007703 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 205918007704 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 205918007705 catalytic triad [active] 205918007706 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 205918007707 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 205918007708 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007709 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007710 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918007711 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 205918007712 substrate binding site [chemical binding]; other site 205918007713 oxyanion hole (OAH) forming residues; other site 205918007714 trimer interface [polypeptide binding]; other site 205918007715 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 205918007716 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 205918007717 Cytochrome c; Region: Cytochrom_C; cl11414 205918007718 Cupin domain; Region: Cupin_2; cl09118 205918007719 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 205918007720 Peptidase S24, S26A and S26B 205918007721 Y-family of DNA polymerases; Region: PolY; cl12025 205918007722 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918007723 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918007724 hypothetical protein 205918007725 Phage integrase 205918007726 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 205918007727 classical (c) SDRs; Region: SDR_c; cd05233 205918007728 NAD(P) binding site [chemical binding]; other site 205918007729 active site 205918007730 Isochorismatase family; Region: Isochorismatase; pfam00857 205918007731 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 205918007732 catalytic triad [active] 205918007733 conserved cis-peptide bond; other site 205918007734 Uncharacterized conserved protein [Function unknown]; Region: COG4715 205918007735 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 205918007736 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918007737 ATP binding site [chemical binding]; other site 205918007738 putative Mg++ binding site [ion binding]; other site 205918007739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918007740 nucleotide binding region [chemical binding]; other site 205918007741 ATP-binding site [chemical binding]; other site 205918007742 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 205918007743 transcription-repair coupling factor; Provisional; Region: PRK10689 205918007744 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 205918007745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918007746 ATP binding site [chemical binding]; other site 205918007747 putative Mg++ binding site [ion binding]; other site 205918007748 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918007749 nucleotide binding region [chemical binding]; other site 205918007750 ATP-binding site [chemical binding]; other site 205918007751 TRCF domain; Region: TRCF; cl04088 205918007752 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 205918007753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918007754 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 205918007755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918007756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918007757 putative substrate translocation pore; other site 205918007758 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007759 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007760 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007761 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007762 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007763 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007764 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007765 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007766 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007767 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007768 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918007769 citrate-proton symporter; Provisional; Region: PRK15075 205918007770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918007771 putative substrate translocation pore; other site 205918007772 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007773 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007774 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007775 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007776 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007777 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007778 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007779 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007780 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007781 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918007782 ApbE family; Region: ApbE; cl00643 205918007783 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 205918007784 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918007785 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205918007786 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 205918007787 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 205918007788 active site 205918007789 catalytic site [active] 205918007790 metal binding site [ion binding]; metal-binding site 205918007791 PilZ domain; Region: PilZ; cl01260 205918007792 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 205918007793 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205918007794 FtsX-like permease family; Region: FtsX; cl15850 205918007795 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007796 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007797 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007798 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007799 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 205918007800 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205918007801 Walker A/P-loop; other site 205918007802 ATP binding site [chemical binding]; other site 205918007803 Q-loop/lid; other site 205918007804 ABC transporter signature motif; other site 205918007805 Walker B; other site 205918007806 D-loop; other site 205918007807 H-loop/switch region; other site 205918007808 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 205918007809 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205918007810 FtsX-like permease family; Region: FtsX; cl15850 205918007811 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007812 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007813 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007814 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007815 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 205918007816 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 205918007817 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 205918007818 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 205918007819 VacJ like lipoprotein; Region: VacJ; cl01073 205918007820 PilZ domain; Region: PilZ; cl01260 205918007821 Response regulator receiver domain; Region: Response_reg; pfam00072 205918007822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918007823 active site 205918007824 phosphorylation site [posttranslational modification] 205918007825 intermolecular recognition site; other site 205918007826 dimerization interface [polypeptide binding]; other site 205918007827 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 205918007828 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 205918007829 anti sigma factor interaction site; other site 205918007830 regulatory phosphorylation site [posttranslational modification]; other site 205918007831 transaldolase-like protein; Provisional; Region: PTZ00411 205918007832 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 205918007833 active site 205918007834 dimer interface [polypeptide binding]; other site 205918007835 catalytic residue [active] 205918007836 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 205918007837 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 205918007838 metal binding site [ion binding]; metal-binding site 205918007839 dimer interface [polypeptide binding]; other site 205918007840 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918007841 Catalytic site [active] 205918007842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918007843 dimer interface [polypeptide binding]; other site 205918007844 phosphorylation site [posttranslational modification] 205918007845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918007846 ATP binding site [chemical binding]; other site 205918007847 Mg2+ binding site [ion binding]; other site 205918007848 G-X-G motif; other site 205918007849 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 205918007850 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 205918007851 tetramer interface [polypeptide binding]; other site 205918007852 active site 205918007853 Mg2+/Mn2+ binding site [ion binding]; other site 205918007854 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918007855 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 205918007856 ATP binding site [chemical binding]; other site 205918007857 substrate interface [chemical binding]; other site 205918007858 1 probable transmembrane helix predicted by TMHMM2.0 205918007859 H+ Antiporter protein; Region: 2A0121; TIGR00900 205918007860 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007861 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007862 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007863 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007864 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007865 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007866 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007867 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007868 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007869 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007870 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007871 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918007872 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918007873 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 205918007874 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918007875 inhibitor-cofactor binding pocket; inhibition site 205918007876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918007877 catalytic residue [active] 205918007878 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 205918007879 Cupin domain; Region: Cupin_2; cl09118 205918007880 Helix-turn-helix domains; Region: HTH; cl00088 205918007881 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918007882 dimerization interface [polypeptide binding]; other site 205918007883 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 205918007884 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 205918007885 conserved hypothetical protein 205918007886 Protein of unknown function (DUF796); Region: DUF796; cl01226 205918007887 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 205918007888 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 205918007889 FMN binding site [chemical binding]; other site 205918007890 active site 205918007891 catalytic residues [active] 205918007892 substrate binding site [chemical binding]; other site 205918007893 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205918007894 Ligand Binding Site [chemical binding]; other site 205918007895 Response regulator receiver domain; Region: Response_reg; pfam00072 205918007896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918007897 active site 205918007898 phosphorylation site [posttranslational modification] 205918007899 intermolecular recognition site; other site 205918007900 dimerization interface [polypeptide binding]; other site 205918007901 CHASE3 domain; Region: CHASE3; cl05000 205918007902 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 205918007903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918007904 putative active site [active] 205918007905 heme pocket [chemical binding]; other site 205918007906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918007907 dimer interface [polypeptide binding]; other site 205918007908 phosphorylation site [posttranslational modification] 205918007909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918007910 ATP binding site [chemical binding]; other site 205918007911 Mg2+ binding site [ion binding]; other site 205918007912 G-X-G motif; other site 205918007913 Response regulator receiver domain; Region: Response_reg; pfam00072 205918007914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918007915 active site 205918007916 phosphorylation site [posttranslational modification] 205918007917 intermolecular recognition site; other site 205918007918 dimerization interface [polypeptide binding]; other site 205918007919 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007920 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918007921 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918007922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918007923 active site 205918007924 phosphorylation site [posttranslational modification] 205918007925 intermolecular recognition site; other site 205918007926 dimerization interface [polypeptide binding]; other site 205918007927 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918007928 DNA binding residues [nucleotide binding] 205918007929 dimerization interface [polypeptide binding]; other site 205918007930 Histidine kinase; Region: HisKA_3; pfam07730 205918007931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 205918007932 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 205918007933 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 205918007934 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918007935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 205918007936 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 205918007937 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cd00741 205918007938 nucleophilic elbow; other site 205918007939 catalytic triad; other site 205918007940 peptide synthase; Validated; Region: PRK05691 205918007941 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007942 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918007943 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918007944 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007945 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007946 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918007947 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918007948 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007949 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007950 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918007951 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 205918007952 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007953 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007954 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918007955 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 205918007956 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918007957 inhibitor-cofactor binding pocket; inhibition site 205918007958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918007959 catalytic residue [active] 205918007960 MbtH-like protein; Region: MbtH; cl01279 205918007961 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 205918007962 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918007963 ABC-ATPase subunit interface; other site 205918007964 dimer interface [polypeptide binding]; other site 205918007965 putative PBP binding regions; other site 205918007966 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007967 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007968 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007969 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007970 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007971 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007972 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007973 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918007974 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 205918007975 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 205918007976 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 205918007977 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 205918007978 metal binding site [ion binding]; metal-binding site 205918007979 1 probable transmembrane helix predicted by TMHMM2.0 205918007980 1 probable transmembrane helix predicted by TMHMM2.0 205918007981 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 205918007982 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 205918007983 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 205918007984 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 205918007985 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007986 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007987 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007988 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918007989 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 205918007990 Condensation domain; Region: Condensation; pfam00668 205918007991 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918007992 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918007993 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007994 acyl-CoA synthetase; Validated; Region: PRK08308 205918007995 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918007996 peptide synthase; Provisional; Region: PRK12316 205918007997 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918007998 AMP-binding enzyme; Region: AMP-binding; cl15778 205918007999 AMP-binding enzyme; Region: AMP-binding; cl15778 205918008000 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918008001 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 205918008002 AMP-binding enzyme; Region: AMP-binding; cl15778 205918008003 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918008004 peptide synthase; Provisional; Region: PRK12467 205918008005 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918008006 AMP-binding enzyme; Region: AMP-binding; cl15778 205918008007 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918008008 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 205918008009 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918008010 AMP-binding enzyme; Region: AMP-binding; cl15778 205918008011 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 205918008012 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918008013 peptide synthase; Provisional; Region: PRK12467 205918008014 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918008015 AMP-binding enzyme; Region: AMP-binding; cl15778 205918008016 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918008017 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 205918008018 AMP-binding enzyme; Region: AMP-binding; cl15778 205918008019 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918008020 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 205918008021 Secretin and TonB N terminus short domain; Region: STN; cl06624 205918008022 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918008023 N-terminal plug; other site 205918008024 ligand-binding site [chemical binding]; other site 205918008025 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 205918008026 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918008027 N-terminal plug; other site 205918008028 ligand-binding site [chemical binding]; other site 205918008029 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 205918008030 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205918008031 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918008032 Walker A/P-loop; other site 205918008033 ATP binding site [chemical binding]; other site 205918008034 ABC transporter signature motif; other site 205918008035 Walker B; other site 205918008036 D-loop; other site 205918008037 H-loop/switch region; other site 205918008038 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008039 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008040 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008041 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008042 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008043 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 205918008044 1 probable transmembrane helix predicted by TMHMM2.0 205918008045 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 205918008046 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205918008047 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918008048 catalytic residue [active] 205918008049 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 205918008050 active site 205918008051 dimer interface [polypeptide binding]; other site 205918008052 1 probable transmembrane helix predicted by TMHMM2.0 205918008053 calcium-activated chloride channel protein 1; Region: hCaCC; TIGR00868 205918008054 1 probable transmembrane helix predicted by TMHMM2.0 205918008055 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918008056 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 205918008057 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205918008058 Walker A/P-loop; other site 205918008059 ATP binding site [chemical binding]; other site 205918008060 Q-loop/lid; other site 205918008061 ABC transporter signature motif; other site 205918008062 Walker B; other site 205918008063 D-loop; other site 205918008064 H-loop/switch region; other site 205918008065 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205918008066 FtsX-like permease family; Region: FtsX; cl15850 205918008067 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008068 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008069 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008070 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008071 macrolide transporter subunit MacA; Provisional; Region: PRK11578 205918008072 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918008073 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918008074 1 probable transmembrane helix predicted by TMHMM2.0 205918008075 Penicillin amidase; Region: Penicil_amidase; pfam01804 205918008076 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 205918008077 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 205918008078 active site 205918008079 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 205918008080 1 probable transmembrane helix predicted by TMHMM2.0 205918008081 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 205918008082 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918008083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918008084 homodimer interface [polypeptide binding]; other site 205918008085 catalytic residue [active] 205918008086 excinuclease ABC subunit B; Provisional; Region: PRK05298 205918008087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918008088 ATP binding site [chemical binding]; other site 205918008089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918008090 nucleotide binding region [chemical binding]; other site 205918008091 ATP-binding site [chemical binding]; other site 205918008092 Ultra-violet resistance protein B; Region: UvrB; pfam12344 205918008093 UvrB/uvrC motif; Region: UVR; pfam02151 205918008094 putative transposase OrfB; Reviewed; Region: PHA02517 205918008095 HTH-like domain; Region: HTH_21; pfam13276 205918008096 Integrase core domain; Region: rve; cl01316 205918008097 Integrase core domain; Region: rve_3; cl15866 205918008098 Helix-turn-helix domains; Region: HTH; cl00088 205918008099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918008100 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 205918008101 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 205918008102 HIGH motif; other site 205918008103 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 205918008104 active site 205918008105 KMSKS motif; other site 205918008106 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 205918008107 active site 205918008108 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 205918008109 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 205918008110 FMN binding site [chemical binding]; other site 205918008111 active site 205918008112 catalytic residues [active] 205918008113 substrate binding site [chemical binding]; other site 205918008114 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 205918008115 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 205918008116 putative dimer interface [polypeptide binding]; other site 205918008117 PAS fold; Region: PAS_3; pfam08447 205918008118 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 205918008119 PAS domain S-box; Region: sensory_box; TIGR00229 205918008120 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918008121 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918008122 metal binding site [ion binding]; metal-binding site 205918008123 active site 205918008124 I-site; other site 205918008125 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918008126 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918008127 Helix-turn-helix domains; Region: HTH; cl00088 205918008128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918008129 dimerization interface [polypeptide binding]; other site 205918008130 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 205918008131 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 205918008132 substrate binding site [chemical binding]; other site 205918008133 ligand binding site [chemical binding]; other site 205918008134 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 205918008135 substrate binding site [chemical binding]; other site 205918008136 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 205918008137 tartrate dehydrogenase; Provisional; Region: PRK08194 205918008138 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 205918008139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918008140 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 205918008141 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 205918008142 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 205918008143 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 205918008144 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 205918008145 active site 205918008146 intersubunit interface [polypeptide binding]; other site 205918008147 catalytic residue [active] 205918008148 galactonate dehydratase; Provisional; Region: PRK14017 205918008149 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 205918008150 putative active site pocket [active] 205918008151 putative metal binding site [ion binding]; other site 205918008152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918008153 D-galactonate transporter; Region: 2A0114; TIGR00893 205918008154 putative substrate translocation pore; other site 205918008155 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008156 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008157 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008158 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008159 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008160 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008161 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008162 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008163 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008164 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008165 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205918008166 Helix-turn-helix domains; Region: HTH; cl00088 205918008167 Bacterial transcriptional regulator; Region: IclR; pfam01614 205918008168 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 205918008169 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 205918008170 putative NAD(P) binding site [chemical binding]; other site 205918008171 putative substrate binding site [chemical binding]; other site 205918008172 catalytic Zn binding site [ion binding]; other site 205918008173 structural Zn binding site [ion binding]; other site 205918008174 dimer interface [polypeptide binding]; other site 205918008175 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 205918008176 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 205918008177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918008178 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 205918008179 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 205918008180 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 205918008181 Ligand binding site [chemical binding]; other site 205918008182 Electron transfer flavoprotein domain; Region: ETF; pfam01012 205918008183 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 205918008184 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 205918008185 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 205918008186 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918008187 substrate binding pocket [chemical binding]; other site 205918008188 membrane-bound complex binding site; other site 205918008189 hinge residues; other site 205918008190 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 205918008191 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918008192 ligand binding site [chemical binding]; other site 205918008193 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 205918008194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918008195 DNA-binding site [nucleotide binding]; DNA binding site 205918008196 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918008197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918008198 homodimer interface [polypeptide binding]; other site 205918008199 catalytic residue [active] 205918008200 Flagellin N-methylase; Region: FliB; cl00497 205918008201 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 205918008202 putative lipid binding site [chemical binding]; other site 205918008203 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 205918008204 dimer interface [polypeptide binding]; other site 205918008205 Citrate synthase; Region: Citrate_synt; pfam00285 205918008206 active site 205918008207 citrylCoA binding site [chemical binding]; other site 205918008208 NADH binding [chemical binding]; other site 205918008209 cationic pore residues; other site 205918008210 oxalacetate/citrate binding site [chemical binding]; other site 205918008211 coenzyme A binding site [chemical binding]; other site 205918008212 catalytic triad [active] 205918008213 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 205918008214 Iron-sulfur protein interface; other site 205918008215 proximal quinone binding site [chemical binding]; other site 205918008216 SdhD (CybS) interface [polypeptide binding]; other site 205918008217 proximal heme binding site [chemical binding]; other site 205918008218 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008219 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008220 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008221 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 205918008222 SdhC subunit interface [polypeptide binding]; other site 205918008223 proximal heme binding site [chemical binding]; other site 205918008224 cardiolipin binding site; other site 205918008225 Iron-sulfur protein interface; other site 205918008226 proximal quinone binding site [chemical binding]; other site 205918008227 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008228 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008229 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008230 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 205918008231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918008232 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 205918008233 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 205918008234 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 205918008235 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 205918008236 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 205918008237 TPP-binding site [chemical binding]; other site 205918008238 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 205918008239 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 205918008240 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 205918008241 E3 interaction surface; other site 205918008242 lipoyl attachment site [posttranslational modification]; other site 205918008243 e3 binding domain; Region: E3_binding; pfam02817 205918008244 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 205918008245 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 205918008246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918008247 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918008248 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205918008249 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 205918008250 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918008251 CoA-ligase; Region: Ligase_CoA; cl02894 205918008252 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 205918008253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918008254 CoA-ligase; Region: Ligase_CoA; cl02894 205918008255 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205918008256 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 205918008257 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008258 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008259 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008260 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008261 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008262 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008263 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008264 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008265 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008266 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008267 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008268 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008269 heat shock protein 90; Provisional; Region: PRK05218 205918008270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918008271 ATP binding site [chemical binding]; other site 205918008272 Mg2+ binding site [ion binding]; other site 205918008273 G-X-G motif; other site 205918008274 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 205918008275 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918008276 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 205918008277 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 205918008278 dimer interface [polypeptide binding]; other site 205918008279 active site 205918008280 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 205918008281 active site 1 [active] 205918008282 dimer interface [polypeptide binding]; other site 205918008283 active site 2 [active] 205918008284 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918008285 dimerization interface [polypeptide binding]; other site 205918008286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918008287 dimer interface [polypeptide binding]; other site 205918008288 phosphorylation site [posttranslational modification] 205918008289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918008290 ATP binding site [chemical binding]; other site 205918008291 Mg2+ binding site [ion binding]; other site 205918008292 G-X-G motif; other site 205918008293 Response regulator receiver domain; Region: Response_reg; pfam00072 205918008294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008295 active site 205918008296 phosphorylation site [posttranslational modification] 205918008297 intermolecular recognition site; other site 205918008298 dimerization interface [polypeptide binding]; other site 205918008299 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008300 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008301 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 205918008302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918008303 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 205918008304 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 205918008305 1 probable transmembrane helix predicted by TMHMM2.0 205918008306 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205918008307 catalytic core [active] 205918008308 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 205918008309 CoenzymeA binding site [chemical binding]; other site 205918008310 subunit interaction site [polypeptide binding]; other site 205918008311 PHB binding site; other site 205918008312 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918008313 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918008314 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918008315 1 probable transmembrane helix predicted by TMHMM2.0 205918008316 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 205918008317 Domain of unknown function DUF20; Region: UPF0118; pfam01594 205918008318 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008319 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008320 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008321 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008322 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008323 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008324 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008325 EF-hand domain pair; Region: EF_hand_6; pfam13833 205918008326 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918008327 dimerization interface [polypeptide binding]; other site 205918008328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918008329 dimer interface [polypeptide binding]; other site 205918008330 phosphorylation site [posttranslational modification] 205918008331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918008332 ATP binding site [chemical binding]; other site 205918008333 Mg2+ binding site [ion binding]; other site 205918008334 G-X-G motif; other site 205918008335 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008336 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008337 osmolarity response regulator; Provisional; Region: ompR; PRK09468 205918008338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008339 active site 205918008340 phosphorylation site [posttranslational modification] 205918008341 intermolecular recognition site; other site 205918008342 dimerization interface [polypeptide binding]; other site 205918008343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918008344 DNA binding site [nucleotide binding] 205918008345 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 205918008346 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 205918008347 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 205918008348 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 205918008349 Fimbrial protein; Region: Fimbrial; cl01416 205918008350 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 205918008351 PapC N-terminal domain; Region: PapC_N; pfam13954 205918008352 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 205918008353 PapC C-terminal domain; Region: PapC_C; pfam13953 205918008354 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 205918008355 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 205918008356 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 205918008357 1 probable transmembrane helix predicted by TMHMM2.0 205918008358 Fimbrial protein; Region: Fimbrial; cl01416 205918008359 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918008360 RHS Repeat; Region: RHS_repeat; cl11982 205918008361 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918008362 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008363 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008364 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008365 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918008366 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918008367 DNA binding residues [nucleotide binding] 205918008368 dimerization interface [polypeptide binding]; other site 205918008369 potassium-transporting ATPase subunit F; Provisional; Region: kdbF; PRK14740 205918008370 1 probable transmembrane helix predicted by TMHMM2.0 205918008371 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 205918008372 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008373 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008374 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008375 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008376 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008377 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008378 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008379 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008380 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008381 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008382 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 205918008383 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205918008384 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918008385 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008386 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008387 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008388 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008389 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008390 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008391 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918008392 K+-transporting ATPase, c chain; Region: KdpC; cl00944 205918008393 1 probable transmembrane helix predicted by TMHMM2.0 205918008394 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 205918008395 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 205918008396 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 205918008397 Ligand Binding Site [chemical binding]; other site 205918008398 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 205918008399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918008400 dimer interface [polypeptide binding]; other site 205918008401 phosphorylation site [posttranslational modification] 205918008402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918008403 ATP binding site [chemical binding]; other site 205918008404 Mg2+ binding site [ion binding]; other site 205918008405 G-X-G motif; other site 205918008406 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008407 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008408 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008409 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 205918008410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008411 active site 205918008412 phosphorylation site [posttranslational modification] 205918008413 intermolecular recognition site; other site 205918008414 dimerization interface [polypeptide binding]; other site 205918008415 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918008416 DNA binding site [nucleotide binding] 205918008417 MoxR-like ATPases [General function prediction only]; Region: COG0714 205918008418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918008419 Walker A motif; other site 205918008420 ATP binding site [chemical binding]; other site 205918008421 Walker B motif; other site 205918008422 arginine finger; other site 205918008423 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 205918008424 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 205918008425 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008426 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008427 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 205918008428 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 205918008429 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 205918008430 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008431 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008432 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008433 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008434 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008435 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008436 CHAD domain; Region: CHAD; cl10506 205918008437 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 205918008438 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 205918008439 active site 205918008440 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 205918008441 active site 2 [active] 205918008442 active site 1 [active] 205918008443 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 205918008444 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008445 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008446 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918008447 dimerization interface [polypeptide binding]; other site 205918008448 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918008449 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918008450 dimer interface [polypeptide binding]; other site 205918008451 putative CheW interface [polypeptide binding]; other site 205918008452 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008453 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008454 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 205918008455 active site 205918008456 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 205918008457 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918008458 substrate binding pocket [chemical binding]; other site 205918008459 membrane-bound complex binding site; other site 205918008460 hinge residues; other site 205918008461 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 205918008462 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918008463 catalytic residue [active] 205918008464 DoxX; Region: DoxX; cl00976 205918008465 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008466 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008467 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008468 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918008469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918008470 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 205918008471 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 205918008472 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 205918008473 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 205918008474 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008475 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008476 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008477 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008478 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008479 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008480 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008481 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008482 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008483 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008484 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 205918008485 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205918008486 Walker A/P-loop; other site 205918008487 ATP binding site [chemical binding]; other site 205918008488 Q-loop/lid; other site 205918008489 ABC transporter signature motif; other site 205918008490 Walker B; other site 205918008491 D-loop; other site 205918008492 H-loop/switch region; other site 205918008493 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 205918008494 active site 205918008495 catalytic triad [active] 205918008496 oxyanion hole [active] 205918008497 switch loop; other site 205918008498 L,D-transpeptidase; Provisional; Region: PRK10260 205918008499 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 205918008500 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918008501 NeuB family; Region: NeuB; cl00496 205918008502 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 205918008503 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 205918008504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918008505 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 205918008506 1 probable transmembrane helix predicted by TMHMM2.0 205918008507 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 205918008508 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205918008509 Ligand Binding Site [chemical binding]; other site 205918008510 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 205918008511 Helix-turn-helix domains; Region: HTH; cl00088 205918008512 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 205918008513 substrate binding site [chemical binding]; other site 205918008514 dimerization interface [polypeptide binding]; other site 205918008515 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 205918008516 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 205918008517 Active Sites [active] 205918008518 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918008519 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 205918008520 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 205918008521 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 205918008522 chorismate binding enzyme; Region: Chorismate_bind; cl10555 205918008523 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918008524 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 205918008525 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 205918008526 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 205918008527 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008528 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008529 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008530 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008531 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008532 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918008533 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 205918008534 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918008535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918008536 DNA-binding site [nucleotide binding]; DNA binding site 205918008537 FCD domain; Region: FCD; cl11656 205918008538 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 205918008539 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 205918008540 tetramer interface [polypeptide binding]; other site 205918008541 active site 205918008542 Mg2+/Mn2+ binding site [ion binding]; other site 205918008543 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 205918008544 dimer interface [polypeptide binding]; other site 205918008545 Citrate synthase; Region: Citrate_synt; pfam00285 205918008546 active site 205918008547 citrylCoA binding site [chemical binding]; other site 205918008548 oxalacetate/citrate binding site [chemical binding]; other site 205918008549 coenzyme A binding site [chemical binding]; other site 205918008550 catalytic triad [active] 205918008551 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 205918008552 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 205918008553 substrate binding site [chemical binding]; other site 205918008554 ligand binding site [chemical binding]; other site 205918008555 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 205918008556 substrate binding site [chemical binding]; other site 205918008557 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 205918008558 PrpF protein; Region: PrpF; pfam04303 205918008559 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 205918008560 phosphoenolpyruvate synthase; Validated; Region: PRK06464 205918008561 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 205918008562 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 205918008563 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 205918008564 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918008565 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 205918008566 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 205918008567 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 205918008568 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008569 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008570 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008571 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008572 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008573 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008574 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918008575 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 205918008576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918008577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918008578 DNA binding residues [nucleotide binding] 205918008579 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 205918008580 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918008581 ligand binding site [chemical binding]; other site 205918008582 1 probable transmembrane helix predicted by TMHMM2.0 205918008583 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 205918008584 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 205918008585 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 205918008586 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 205918008587 [4Fe-4S] binding site [ion binding]; other site 205918008588 molybdopterin cofactor binding site; other site 205918008589 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 205918008590 molybdopterin cofactor binding site; other site 205918008591 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 205918008592 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 205918008593 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 205918008594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918008595 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 205918008596 active site 205918008597 Catalytic domain of Protein Kinases; Region: PKc; cd00180 205918008598 active site 205918008599 ATP binding site [chemical binding]; other site 205918008600 substrate binding site [chemical binding]; other site 205918008601 activation loop (A-loop); other site 205918008602 1 probable transmembrane helix predicted by TMHMM2.0 205918008603 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 205918008604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918008605 putative substrate translocation pore; other site 205918008606 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008607 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008608 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008609 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008610 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008611 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008612 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008613 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008614 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008615 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008616 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008617 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008618 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 205918008619 active site 205918008620 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 205918008621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008622 active site 205918008623 phosphorylation site [posttranslational modification] 205918008624 intermolecular recognition site; other site 205918008625 dimerization interface [polypeptide binding]; other site 205918008626 ANTAR domain; Region: ANTAR; cl04297 205918008627 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 205918008628 NMT1-like family; Region: NMT1_2; cl15260 205918008629 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 205918008630 quinone interaction residues [chemical binding]; other site 205918008631 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 205918008632 active site 205918008633 catalytic residues [active] 205918008634 FMN binding site [chemical binding]; other site 205918008635 substrate binding site [chemical binding]; other site 205918008636 Ribosome modulation factor; Region: RMF; cl01207 205918008637 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 205918008638 THUMP domain; Region: THUMP; cl12076 205918008639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918008640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918008641 S-adenosylmethionine binding site [chemical binding]; other site 205918008642 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918008643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918008644 dimerization interface [polypeptide binding]; other site 205918008645 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918008646 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918008647 dimer interface [polypeptide binding]; other site 205918008648 putative CheW interface [polypeptide binding]; other site 205918008649 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008650 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008651 CHASE domain; Region: CHASE; cl01369 205918008652 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918008653 PAS domain; Region: PAS_9; pfam13426 205918008654 putative active site [active] 205918008655 heme pocket [chemical binding]; other site 205918008656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918008657 PAS fold; Region: PAS_3; pfam08447 205918008658 putative active site [active] 205918008659 heme pocket [chemical binding]; other site 205918008660 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918008661 metal binding site [ion binding]; metal-binding site 205918008662 active site 205918008663 I-site; other site 205918008664 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008665 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008666 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 205918008667 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918008668 Protein with unknown function (DUF469); Region: DUF469; cl01237 205918008669 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 205918008670 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918008671 substrate binding pocket [chemical binding]; other site 205918008672 membrane-bound complex binding site; other site 205918008673 hinge residues; other site 205918008674 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918008675 substrate binding pocket [chemical binding]; other site 205918008676 membrane-bound complex binding site; other site 205918008677 hinge residues; other site 205918008678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918008679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918008680 dimer interface [polypeptide binding]; other site 205918008681 phosphorylation site [posttranslational modification] 205918008682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918008683 ATP binding site [chemical binding]; other site 205918008684 Mg2+ binding site [ion binding]; other site 205918008685 G-X-G motif; other site 205918008686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008687 active site 205918008688 phosphorylation site [posttranslational modification] 205918008689 intermolecular recognition site; other site 205918008690 dimerization interface [polypeptide binding]; other site 205918008691 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 205918008692 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918008693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008694 active site 205918008695 phosphorylation site [posttranslational modification] 205918008696 intermolecular recognition site; other site 205918008697 dimerization interface [polypeptide binding]; other site 205918008698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918008699 DNA binding residues [nucleotide binding] 205918008700 dimerization interface [polypeptide binding]; other site 205918008701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918008702 active site 205918008703 phosphorylation site [posttranslational modification] 205918008704 intermolecular recognition site; other site 205918008705 dimerization interface [polypeptide binding]; other site 205918008706 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 205918008707 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205918008708 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 205918008709 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 205918008710 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008711 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008712 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 205918008713 OpgC protein; Region: OpgC_C; cl00792 205918008714 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008715 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008716 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008717 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008718 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008719 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008720 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008721 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008722 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008723 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008724 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 205918008725 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 205918008726 Helix-turn-helix domains; Region: HTH; cl00088 205918008727 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918008728 dimerization interface [polypeptide binding]; other site 205918008729 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 205918008730 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 205918008731 active site 205918008732 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 205918008733 heterodimer interface [polypeptide binding]; other site 205918008734 active site 205918008735 benzoate transport; Region: 2A0115; TIGR00895 205918008736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918008737 putative substrate translocation pore; other site 205918008738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918008739 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008740 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008741 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008742 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008743 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008744 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008745 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008746 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008747 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008748 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008749 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008750 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008751 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 205918008752 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 205918008753 tetramer interface [polypeptide binding]; other site 205918008754 active site 205918008755 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 205918008756 outer membrane porin, OprD family; Region: OprD; pfam03573 205918008757 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 205918008758 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008759 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008760 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008761 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008762 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008763 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008764 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008765 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008766 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008767 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918008769 D-galactonate transporter; Region: 2A0114; TIGR00893 205918008770 putative substrate translocation pore; other site 205918008771 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008772 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008773 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008774 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008775 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008776 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008777 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008778 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008779 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008780 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 205918008781 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 205918008782 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 205918008783 dimer interface [polypeptide binding]; other site 205918008784 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 205918008785 active site 205918008786 Fe binding site [ion binding]; other site 205918008787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918008788 Helix-turn-helix domains; Region: HTH; cl00088 205918008789 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 205918008790 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 205918008791 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 205918008792 shikimate binding site; other site 205918008793 NAD(P) binding site [chemical binding]; other site 205918008794 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 205918008795 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 205918008796 active site 205918008797 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 205918008798 1 probable transmembrane helix predicted by TMHMM2.0 205918008799 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 205918008800 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 205918008801 GTP binding site; other site 205918008802 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 205918008803 MPT binding site; other site 205918008804 trimer interface [polypeptide binding]; other site 205918008805 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 205918008806 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 205918008807 dimer interface [polypeptide binding]; other site 205918008808 putative functional site; other site 205918008809 putative MPT binding site; other site 205918008810 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 205918008811 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918008812 active site 205918008813 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918008814 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 205918008815 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 205918008816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918008817 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008818 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008819 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008820 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008821 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008822 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008823 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008824 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008825 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008826 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008827 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008828 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008829 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008830 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918008831 Helix-turn-helix domains; Region: HTH; cl00088 205918008832 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 205918008833 FecR protein; Region: FecR; pfam04773 205918008834 1 probable transmembrane helix predicted by TMHMM2.0 205918008835 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 205918008836 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 205918008837 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 205918008838 active site 205918008839 Endonuclease I; Region: Endonuclease_1; cl01003 205918008840 DNA-specific endonuclease I; Provisional; Region: PRK15137 205918008841 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 205918008842 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 205918008843 1 probable transmembrane helix predicted by TMHMM2.0 205918008844 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 205918008845 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 205918008846 ligand binding site [chemical binding]; other site 205918008847 1 probable transmembrane helix predicted by TMHMM2.0 205918008848 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 205918008849 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 205918008850 Walker A/P-loop; other site 205918008851 ATP binding site [chemical binding]; other site 205918008852 Q-loop/lid; other site 205918008853 ABC transporter signature motif; other site 205918008854 Walker B; other site 205918008855 D-loop; other site 205918008856 H-loop/switch region; other site 205918008857 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 205918008858 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918008859 TM-ABC transporter signature motif; other site 205918008860 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008861 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008862 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008863 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008864 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008865 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008866 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008867 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008868 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918008869 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205918008870 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205918008871 DNA binding site [nucleotide binding] 205918008872 domain linker motif; other site 205918008873 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205918008874 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205918008875 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 205918008876 substrate binding site [chemical binding]; other site 205918008877 dimer interface [polypeptide binding]; other site 205918008878 ATP binding site [chemical binding]; other site 205918008879 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 205918008880 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 205918008881 active site 205918008882 tetramer interface [polypeptide binding]; other site 205918008883 Potato inhibitor I family; Region: potato_inhibit; cl15459 205918008884 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 205918008885 DNA-binding site [nucleotide binding]; DNA binding site 205918008886 RNA-binding motif; other site 205918008887 1 probable transmembrane helix predicted by TMHMM2.0 205918008888 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 205918008889 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 205918008890 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 205918008891 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 205918008892 active site 205918008893 dimer interface [polypeptide binding]; other site 205918008894 motif 1; other site 205918008895 motif 2; other site 205918008896 motif 3; other site 205918008897 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 205918008898 anticodon binding site; other site 205918008899 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 205918008900 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 205918008901 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 205918008902 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 205918008903 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 205918008904 23S rRNA binding site [nucleotide binding]; other site 205918008905 L21 binding site [polypeptide binding]; other site 205918008906 L13 binding site [polypeptide binding]; other site 205918008907 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 205918008908 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 205918008909 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 205918008910 dimer interface [polypeptide binding]; other site 205918008911 motif 1; other site 205918008912 active site 205918008913 motif 2; other site 205918008914 motif 3; other site 205918008915 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 205918008916 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 205918008917 putative tRNA-binding site [nucleotide binding]; other site 205918008918 B3/4 domain; Region: B3_4; cl11458 205918008919 tRNA synthetase B5 domain; Region: B5; cl08394 205918008920 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 205918008921 dimer interface [polypeptide binding]; other site 205918008922 motif 1; other site 205918008923 motif 3; other site 205918008924 motif 2; other site 205918008925 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 205918008926 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 205918008927 IHF dimer interface [polypeptide binding]; other site 205918008928 IHF - DNA interface [nucleotide binding]; other site 205918008929 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 205918008930 DNA binding residues [nucleotide binding] 205918008931 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 205918008932 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918008933 substrate binding pocket [chemical binding]; other site 205918008934 membrane-bound complex binding site; other site 205918008935 hinge residues; other site 205918008936 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 205918008937 Uncharacterized conserved protein [Function unknown]; Region: COG3777 205918008938 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 205918008939 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 205918008940 active site 2 [active] 205918008941 active site 1 [active] 205918008942 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 205918008943 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 205918008944 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 205918008945 Ligand binding site [chemical binding]; other site 205918008946 Electron transfer flavoprotein domain; Region: ETF; pfam01012 205918008947 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 205918008948 CoA-transferase family III; Region: CoA_transf_3; pfam02515 205918008949 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918008950 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918008951 active site 205918008952 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 205918008953 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 205918008954 TPP-binding site; other site 205918008955 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 205918008956 PYR/PP interface [polypeptide binding]; other site 205918008957 dimer interface [polypeptide binding]; other site 205918008958 TPP binding site [chemical binding]; other site 205918008959 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 205918008960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918008961 putative substrate translocation pore; other site 205918008962 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008963 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008964 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008965 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008966 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008967 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008968 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008969 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008970 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008971 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008972 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008973 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918008974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918008975 Helix-turn-helix domains; Region: HTH; cl00088 205918008976 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 205918008977 putative dimerization interface [polypeptide binding]; other site 205918008978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918008979 putative substrate translocation pore; other site 205918008980 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008981 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008982 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008983 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008984 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008985 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008986 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008987 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008988 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008989 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918008990 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008991 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008992 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918008993 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918008994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918008995 DNA-binding site [nucleotide binding]; DNA binding site 205918008996 FCD domain; Region: FCD; cl11656 205918008997 short chain dehydrogenase; Provisional; Region: PRK12829 205918008998 classical (c) SDRs; Region: SDR_c; cd05233 205918008999 NAD(P) binding site [chemical binding]; other site 205918009000 active site 205918009001 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 205918009002 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 205918009003 benzoate transport; Region: 2A0115; TIGR00895 205918009004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009005 putative substrate translocation pore; other site 205918009006 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009007 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009008 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009009 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009010 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009011 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009012 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009013 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009014 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009015 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009016 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009017 CHASE3 domain; Region: CHASE3; cl05000 205918009018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918009019 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009021 dimer interface [polypeptide binding]; other site 205918009022 putative CheW interface [polypeptide binding]; other site 205918009023 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009024 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009025 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918009026 dimerization interface [polypeptide binding]; other site 205918009027 putative DNA binding site [nucleotide binding]; other site 205918009028 putative Zn2+ binding site [ion binding]; other site 205918009029 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 205918009030 active site 205918009031 FMN binding site [chemical binding]; other site 205918009032 substrate binding site [chemical binding]; other site 205918009033 homotetramer interface [polypeptide binding]; other site 205918009034 catalytic residue [active] 205918009035 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918009036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918009037 Helix-turn-helix domains; Region: HTH; cl00088 205918009038 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918009039 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918009040 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918009041 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 205918009042 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009043 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009044 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009045 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009046 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009047 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009048 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009049 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009050 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009051 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009052 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009053 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009054 UreD urease accessory protein; Region: UreD; cl00530 205918009055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918009056 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918009057 Switch II region; other site 205918009058 G4 box; other site 205918009059 G5 box; other site 205918009060 urease subunit alpha; Reviewed; Region: ureC; PRK13308 205918009061 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 205918009062 subunit interactions [polypeptide binding]; other site 205918009063 active site 205918009064 flap region; other site 205918009065 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 205918009066 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 205918009067 alpha-gamma subunit interface [polypeptide binding]; other site 205918009068 beta-gamma subunit interface [polypeptide binding]; other site 205918009069 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 205918009070 alpha-beta subunit interface [polypeptide binding]; other site 205918009071 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 205918009072 UreF; Region: UreF; pfam01730 205918009073 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 205918009074 dimer interface [polypeptide binding]; other site 205918009075 catalytic residues [active] 205918009076 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 205918009077 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 205918009078 Walker A/P-loop; other site 205918009079 ATP binding site [chemical binding]; other site 205918009080 Q-loop/lid; other site 205918009081 ABC transporter signature motif; other site 205918009082 Walker B; other site 205918009083 D-loop; other site 205918009084 H-loop/switch region; other site 205918009085 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 205918009086 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 205918009087 Walker A/P-loop; other site 205918009088 ATP binding site [chemical binding]; other site 205918009089 Q-loop/lid; other site 205918009090 ABC transporter signature motif; other site 205918009091 Walker B; other site 205918009092 D-loop; other site 205918009093 H-loop/switch region; other site 205918009094 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 205918009095 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 205918009096 TM-ABC transporter signature motif; other site 205918009097 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009098 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009099 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009100 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009101 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009102 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009103 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009104 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009105 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 205918009106 TM-ABC transporter signature motif; other site 205918009107 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009108 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009109 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009110 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009111 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009112 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009113 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009114 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009115 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 205918009116 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 205918009117 putative ligand binding site [chemical binding]; other site 205918009118 1 probable transmembrane helix predicted by TMHMM2.0 205918009119 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 205918009120 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 205918009121 ligand binding site [chemical binding]; other site 205918009122 regulator interaction site; other site 205918009123 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 205918009124 ANTAR domain; Region: ANTAR; cl04297 205918009125 Amidase; Region: Amidase; cl11426 205918009126 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 205918009127 NMT1-like family; Region: NMT1_2; cl15260 205918009128 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918009129 1 probable transmembrane helix predicted by TMHMM2.0 205918009130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918009131 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 205918009132 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 205918009133 active site 205918009134 non-prolyl cis peptide bond; other site 205918009135 Arginase family; Region: Arginase; cl00306 205918009136 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 205918009137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918009138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918009139 PAS domain; Region: PAS_9; pfam13426 205918009140 putative active site [active] 205918009141 heme pocket [chemical binding]; other site 205918009142 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918009143 PAS domain; Region: PAS_9; pfam13426 205918009144 putative active site [active] 205918009145 heme pocket [chemical binding]; other site 205918009146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918009147 PAS domain; Region: PAS_9; pfam13426 205918009148 putative active site [active] 205918009149 heme pocket [chemical binding]; other site 205918009150 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918009151 PAS domain; Region: PAS_9; pfam13426 205918009152 putative active site [active] 205918009153 heme pocket [chemical binding]; other site 205918009154 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009155 dimer interface [polypeptide binding]; other site 205918009156 putative CheW interface [polypeptide binding]; other site 205918009157 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 205918009158 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 205918009159 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 205918009160 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 205918009161 1 probable transmembrane helix predicted by TMHMM2.0 205918009162 transcriptional regulator; Provisional; Region: PRK10632 205918009163 Helix-turn-helix domains; Region: HTH; cl00088 205918009164 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918009165 putative effector binding pocket; other site 205918009166 dimerization interface [polypeptide binding]; other site 205918009167 Cache domain; Region: Cache_1; pfam02743 205918009168 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918009169 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009170 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009171 dimer interface [polypeptide binding]; other site 205918009172 putative CheW interface [polypeptide binding]; other site 205918009173 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009174 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009175 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 205918009176 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 205918009177 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 205918009178 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 205918009179 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 205918009180 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 205918009181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918009182 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194 205918009183 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 205918009184 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 205918009185 homodimer interface [polypeptide binding]; other site 205918009186 NADP binding site [chemical binding]; other site 205918009187 substrate binding site [chemical binding]; other site 205918009188 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 205918009189 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 205918009190 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 205918009191 putative active site [active] 205918009192 putative substrate binding site [chemical binding]; other site 205918009193 putative cosubstrate binding site; other site 205918009194 catalytic site [active] 205918009195 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 205918009196 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918009197 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918009198 N-terminal plug; other site 205918009199 ligand-binding site [chemical binding]; other site 205918009200 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 205918009201 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 205918009202 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009203 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009204 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009205 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009206 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009207 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009208 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009209 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009210 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009211 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009212 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009213 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 205918009214 active site 205918009215 catalytic triad [active] 205918009216 dimer interface [polypeptide binding]; other site 205918009217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009218 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918009219 putative substrate translocation pore; other site 205918009220 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009221 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009222 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009223 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009224 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009225 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009226 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009227 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009228 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009229 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009230 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 205918009231 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 205918009232 Strictosidine synthase; Region: Str_synth; pfam03088 205918009233 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 205918009234 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 205918009235 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 205918009236 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009237 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009238 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009239 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009240 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009241 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009242 CHASE3 domain; Region: CHASE3; cl05000 205918009243 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918009244 dimerization interface [polypeptide binding]; other site 205918009245 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009246 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009247 dimer interface [polypeptide binding]; other site 205918009248 putative CheW interface [polypeptide binding]; other site 205918009249 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009250 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009251 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 205918009252 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 205918009253 putative ligand binding site [chemical binding]; other site 205918009254 1 probable transmembrane helix predicted by TMHMM2.0 205918009255 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 205918009256 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 205918009257 active site 205918009258 substrate binding site [chemical binding]; other site 205918009259 Mg2+ binding site [ion binding]; other site 205918009260 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918009261 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918009262 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009263 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009264 dimer interface [polypeptide binding]; other site 205918009265 putative CheW interface [polypeptide binding]; other site 205918009266 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009267 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009268 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918009269 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009270 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009271 dimer interface [polypeptide binding]; other site 205918009272 putative CheW interface [polypeptide binding]; other site 205918009273 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009274 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009275 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 205918009276 homotrimer interaction site [polypeptide binding]; other site 205918009277 putative active site [active] 205918009278 DNA topoisomerase III; Provisional; Region: PRK07726 205918009279 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 205918009280 active site 205918009281 putative interdomain interaction site [polypeptide binding]; other site 205918009282 putative metal-binding site [ion binding]; other site 205918009283 putative nucleotide binding site [chemical binding]; other site 205918009284 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 205918009285 domain I; other site 205918009286 DNA binding groove [nucleotide binding] 205918009287 phosphate binding site [ion binding]; other site 205918009288 domain II; other site 205918009289 domain III; other site 205918009290 nucleotide binding site [chemical binding]; other site 205918009291 catalytic site [active] 205918009292 domain IV; other site 205918009293 HDOD domain; Region: HDOD; pfam08668 205918009294 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205918009295 Cache domain; Region: Cache_1; pfam02743 205918009296 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918009297 dimerization interface [polypeptide binding]; other site 205918009298 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009299 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009300 dimer interface [polypeptide binding]; other site 205918009301 putative CheW interface [polypeptide binding]; other site 205918009302 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009303 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009304 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 205918009305 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 205918009306 Walker A/P-loop; other site 205918009307 ATP binding site [chemical binding]; other site 205918009308 Q-loop/lid; other site 205918009309 ABC transporter signature motif; other site 205918009310 Walker B; other site 205918009311 D-loop; other site 205918009312 H-loop/switch region; other site 205918009313 NMT1-like family; Region: NMT1_2; cl15260 205918009314 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 205918009315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918009316 dimer interface [polypeptide binding]; other site 205918009317 conserved gate region; other site 205918009318 ABC-ATPase subunit interface; other site 205918009319 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009320 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009321 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009322 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009323 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009324 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009325 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 205918009326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918009327 DNA-binding site [nucleotide binding]; DNA binding site 205918009328 UTRA domain; Region: UTRA; cl01230 205918009329 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 205918009330 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 205918009331 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 205918009332 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 205918009333 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 205918009334 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918009335 Walker A/P-loop; other site 205918009336 ATP binding site [chemical binding]; other site 205918009337 Q-loop/lid; other site 205918009338 ABC transporter signature motif; other site 205918009339 Walker B; other site 205918009340 D-loop; other site 205918009341 H-loop/switch region; other site 205918009342 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918009343 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 205918009344 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205918009345 Walker A/P-loop; other site 205918009346 ATP binding site [chemical binding]; other site 205918009347 Q-loop/lid; other site 205918009348 ABC transporter signature motif; other site 205918009349 Walker B; other site 205918009350 D-loop; other site 205918009351 H-loop/switch region; other site 205918009352 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 205918009353 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 205918009354 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 205918009355 active site 205918009356 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918009357 AAA domain; Region: AAA_18; pfam13238 205918009358 active site 205918009359 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 205918009360 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 205918009361 Amidase; Region: Amidase; cl11426 205918009362 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 205918009363 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 205918009364 metal binding site [ion binding]; metal-binding site 205918009365 dimer interface [polypeptide binding]; other site 205918009366 hypothetical protein; Provisional; Region: PRK07079 205918009367 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 205918009368 metal binding site [ion binding]; metal-binding site 205918009369 putative dimer interface [polypeptide binding]; other site 205918009370 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 205918009371 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918009372 Walker A/P-loop; other site 205918009373 ATP binding site [chemical binding]; other site 205918009374 Q-loop/lid; other site 205918009375 ABC transporter signature motif; other site 205918009376 Walker B; other site 205918009377 D-loop; other site 205918009378 H-loop/switch region; other site 205918009379 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918009380 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 205918009381 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918009382 Walker A/P-loop; other site 205918009383 ATP binding site [chemical binding]; other site 205918009384 Q-loop/lid; other site 205918009385 ABC transporter signature motif; other site 205918009386 Walker B; other site 205918009387 D-loop; other site 205918009388 H-loop/switch region; other site 205918009389 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918009390 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 205918009391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918009392 dimer interface [polypeptide binding]; other site 205918009393 conserved gate region; other site 205918009394 putative PBP binding loops; other site 205918009395 ABC-ATPase subunit interface; other site 205918009396 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009397 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009398 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009399 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009400 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009401 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918009403 dimer interface [polypeptide binding]; other site 205918009404 conserved gate region; other site 205918009405 putative PBP binding loops; other site 205918009406 ABC-ATPase subunit interface; other site 205918009407 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009408 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009409 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009410 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009411 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009412 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009413 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 205918009414 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205918009415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918009416 Helix-turn-helix domains; Region: HTH; cl00088 205918009417 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918009418 dimerization interface [polypeptide binding]; other site 205918009419 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 205918009420 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 205918009421 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 205918009422 trimer interface [polypeptide binding]; other site 205918009423 active site 205918009424 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 205918009425 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009426 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009427 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009428 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009429 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009430 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009431 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009432 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009433 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009434 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 205918009435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918009436 non-specific DNA binding site [nucleotide binding]; other site 205918009437 salt bridge; other site 205918009438 sequence-specific DNA binding site [nucleotide binding]; other site 205918009439 Cupin domain; Region: Cupin_2; cl09118 205918009440 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 205918009441 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 205918009442 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205918009443 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 205918009444 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 205918009445 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 205918009446 putative active site [active] 205918009447 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 205918009448 domain_subunit interface; other site 205918009449 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 205918009450 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 205918009451 active site 205918009452 FMN binding site [chemical binding]; other site 205918009453 substrate binding site [chemical binding]; other site 205918009454 3Fe-4S cluster binding site [ion binding]; other site 205918009455 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 205918009456 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009457 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009458 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009459 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009460 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009461 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009462 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009463 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009464 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009465 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009466 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009467 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009468 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 205918009469 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 205918009470 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 205918009471 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 205918009472 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 205918009473 active site 205918009474 dimer interface [polypeptide binding]; other site 205918009475 non-prolyl cis peptide bond; other site 205918009476 insertion regions; other site 205918009477 Cache domain; Region: Cache_1; pfam02743 205918009478 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918009479 metal binding site [ion binding]; metal-binding site 205918009480 active site 205918009481 I-site; other site 205918009482 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009483 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009484 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 205918009485 Protein export membrane protein; Region: SecD_SecF; cl14618 205918009486 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009487 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009488 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009489 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009490 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009491 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009492 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009493 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009494 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009495 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009496 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009497 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009498 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 205918009499 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918009500 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918009501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 205918009502 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 205918009503 Cu(I) binding site [ion binding]; other site 205918009504 Protein of unknown function (DUF461); Region: DUF461; cl01071 205918009505 Gram-negative bacterial tonB protein; Region: TonB; cl10048 205918009506 1 probable transmembrane helix predicted by TMHMM2.0 205918009507 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 205918009508 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918009509 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918009510 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918009511 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 205918009512 1 probable transmembrane helix predicted by TMHMM2.0 205918009513 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 205918009514 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918009515 N-terminal plug; other site 205918009516 ligand-binding site [chemical binding]; other site 205918009517 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 205918009518 active site 205918009519 intersubunit interface [polypeptide binding]; other site 205918009520 Zn2+ binding site [ion binding]; other site 205918009521 Glutaminase; Region: Glutaminase; cl00907 205918009522 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 205918009523 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 205918009524 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205918009525 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918009526 Walker A/P-loop; other site 205918009527 ATP binding site [chemical binding]; other site 205918009528 Q-loop/lid; other site 205918009529 ABC transporter signature motif; other site 205918009530 Walker B; other site 205918009531 D-loop; other site 205918009532 H-loop/switch region; other site 205918009533 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918009534 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918009535 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918009536 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918009537 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918009538 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 205918009539 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918009540 active site 205918009541 catalytic tetrad [active] 205918009542 glucose-1-dehydrogenase; Provisional; Region: PRK08936 205918009543 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 205918009544 NAD binding site [chemical binding]; other site 205918009545 homodimer interface [polypeptide binding]; other site 205918009546 active site 205918009547 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 205918009548 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 205918009549 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009550 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009551 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009552 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009553 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009554 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009555 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009556 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009557 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918009558 Predicted integral membrane protein [Function unknown]; Region: COG0392 205918009559 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 205918009560 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009561 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009562 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009563 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009564 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009565 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009566 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 205918009567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918009568 NAD(P) binding site [chemical binding]; other site 205918009569 active site 205918009570 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 205918009571 FAD binding domain; Region: FAD_binding_4; pfam01565 205918009572 hypothetical protein; Validated; Region: PRK08238 205918009573 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918009574 UbiA prenyltransferase family; Region: UbiA; cl00337 205918009575 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009576 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009577 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009578 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009579 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009580 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009581 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009582 benzoate transport; Region: 2A0115; TIGR00895 205918009583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009584 putative substrate translocation pore; other site 205918009585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009586 putative substrate translocation pore; other site 205918009587 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009588 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009589 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009590 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009591 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009592 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009593 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009594 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009595 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009596 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009597 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009598 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009599 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 205918009600 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 205918009601 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009602 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009603 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009604 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009605 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009606 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009607 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009608 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009609 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009610 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009611 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009612 benzoate transport; Region: 2A0115; TIGR00895 205918009613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009614 putative substrate translocation pore; other site 205918009615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918009616 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009617 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009618 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009619 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009620 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009621 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009622 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009623 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009624 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009625 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009626 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009627 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 205918009628 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 205918009629 NmrA-like family; Region: NmrA; pfam05368 205918009630 NADP binding site [chemical binding]; other site 205918009631 Helix-turn-helix domains; Region: HTH; cl00088 205918009632 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 205918009633 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 205918009634 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918009635 1 probable transmembrane helix predicted by TMHMM2.0 205918009636 pyruvate dehydrogenase; Provisional; Region: PRK09124 205918009637 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 205918009638 PYR/PP interface [polypeptide binding]; other site 205918009639 tetramer interface [polypeptide binding]; other site 205918009640 dimer interface [polypeptide binding]; other site 205918009641 TPP binding site [chemical binding]; other site 205918009642 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 205918009643 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 205918009644 TPP-binding site [chemical binding]; other site 205918009645 Nitrate and nitrite sensing; Region: NIT; pfam08376 205918009646 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918009647 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009648 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009649 dimer interface [polypeptide binding]; other site 205918009650 putative CheW interface [polypeptide binding]; other site 205918009651 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009652 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009653 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 205918009654 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 205918009655 1 probable transmembrane helix predicted by TMHMM2.0 205918009656 general secretion pathway protein K 205918009657 general secretion pathway protein K 205918009658 methyl-accepting chemotaxis protein 205918009659 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918009660 RHS Repeat; Region: RHS_repeat; cl11982 205918009661 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918009662 RHS Repeat; Region: RHS_repeat; cl11982 205918009663 RHS Repeat; Region: RHS_repeat; cl11982 205918009664 RHS Repeat; Region: RHS_repeat; cl11982 205918009665 RHS Repeat; Region: RHS_repeat; cl11982 205918009666 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918009667 RHS Repeat; Region: RHS_repeat; cl11982 205918009668 RHS Repeat; Region: RHS_repeat; cl11982 205918009669 RHS Repeat; Region: RHS_repeat; cl11982 205918009670 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918009671 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 205918009672 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 205918009673 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918009674 FeS/SAM binding site; other site 205918009675 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 205918009676 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 205918009677 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009678 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009679 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009680 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009681 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009682 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009683 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009684 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009685 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009686 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009687 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918009688 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918009689 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205918009690 1 probable transmembrane helix predicted by TMHMM2.0 205918009691 FAD dependent oxidoreductase; Region: DAO; pfam01266 205918009692 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 205918009693 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 205918009694 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 205918009695 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205918009696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918009697 dimer interface [polypeptide binding]; other site 205918009698 conserved gate region; other site 205918009699 putative PBP binding loops; other site 205918009700 ABC-ATPase subunit interface; other site 205918009701 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009702 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009703 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009704 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009705 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009706 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918009708 dimer interface [polypeptide binding]; other site 205918009709 conserved gate region; other site 205918009710 putative PBP binding loops; other site 205918009711 ABC-ATPase subunit interface; other site 205918009712 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009713 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009714 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009715 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009716 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009717 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009718 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205918009719 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918009720 Walker A/P-loop; other site 205918009721 ATP binding site [chemical binding]; other site 205918009722 Q-loop/lid; other site 205918009723 ABC transporter signature motif; other site 205918009724 Walker B; other site 205918009725 D-loop; other site 205918009726 H-loop/switch region; other site 205918009727 TOBE domain; Region: TOBE_2; cl01440 205918009728 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205918009729 Helix-turn-helix domains; Region: HTH; cl00088 205918009730 Bacterial transcriptional regulator; Region: IclR; pfam01614 205918009731 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 205918009732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918009733 S-adenosylmethionine binding site [chemical binding]; other site 205918009734 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 205918009735 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009736 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009737 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009738 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009739 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009740 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009741 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 205918009742 1 probable transmembrane helix predicted by TMHMM2.0 205918009743 Integral membrane protein TerC family; Region: TerC; cl10468 205918009744 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 205918009745 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205918009746 Transporter associated domain; Region: CorC_HlyC; cl08393 205918009747 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009748 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009749 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009750 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009751 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009752 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009753 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009754 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205918009755 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918009756 conserved hypothetical protein 205918009757 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 205918009758 AAA domain; Region: AAA_21; pfam13304 205918009759 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918009760 G1 box; other site 205918009761 GTP/Mg2+ binding site [chemical binding]; other site 205918009762 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918009763 Walker B; other site 205918009764 D-loop; other site 205918009765 H-loop/switch region; other site 205918009766 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 205918009767 active site 205918009768 metal binding site [ion binding]; metal-binding site 205918009769 homotetramer interface [polypeptide binding]; other site 205918009770 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 205918009771 active site 205918009772 dimer interface [polypeptide binding]; other site 205918009773 motif 2; other site 205918009774 putative acetyltransferase YhhY; Provisional; Region: PRK10140 205918009775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918009776 Coenzyme A binding pocket [chemical binding]; other site 205918009777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 205918009778 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 205918009779 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 205918009780 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918009781 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918009782 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918009783 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 205918009784 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 205918009785 GAF domain; Region: GAF; cl15785 205918009786 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918009787 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918009788 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918009789 dimer interface [polypeptide binding]; other site 205918009790 putative CheW interface [polypeptide binding]; other site 205918009791 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009792 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009793 transcriptional regulator; Provisional; Region: PRK10632 205918009794 Helix-turn-helix domains; Region: HTH; cl00088 205918009795 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 205918009796 putative effector binding pocket; other site 205918009797 putative dimerization interface [polypeptide binding]; other site 205918009798 acetylornithine aminotransferase; Provisional; Region: PRK02627 205918009799 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918009800 inhibitor-cofactor binding pocket; inhibition site 205918009801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918009802 catalytic residue [active] 205918009803 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 205918009804 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 205918009805 FOG: CBS domain [General function prediction only]; Region: COG0517 205918009806 DNA polymerase II; Reviewed; Region: PRK05762 205918009807 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 205918009808 active site 205918009809 catalytic site [active] 205918009810 substrate binding site [chemical binding]; other site 205918009811 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 205918009812 active site 205918009813 metal-binding site 205918009814 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 205918009815 NAD-dependent deacetylase; Provisional; Region: PRK05333 205918009816 NAD+ binding site [chemical binding]; other site 205918009817 substrate binding site [chemical binding]; other site 205918009818 Zn binding site [ion binding]; other site 205918009819 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 205918009820 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 205918009821 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 205918009822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918009823 FeS/SAM binding site; other site 205918009824 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 205918009825 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 205918009826 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918009827 ABC-ATPase subunit interface; other site 205918009828 dimer interface [polypeptide binding]; other site 205918009829 putative PBP binding regions; other site 205918009830 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009831 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009832 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009833 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009834 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009835 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009836 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009837 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918009838 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 205918009839 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 205918009840 metal binding site [ion binding]; metal-binding site 205918009841 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 205918009842 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 205918009843 active site 205918009844 catalytic residues [active] 205918009845 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 205918009846 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 205918009847 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 205918009848 ligand binding site [chemical binding]; other site 205918009849 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 205918009850 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 205918009851 Walker A/P-loop; other site 205918009852 ATP binding site [chemical binding]; other site 205918009853 Q-loop/lid; other site 205918009854 ABC transporter signature motif; other site 205918009855 Walker B; other site 205918009856 D-loop; other site 205918009857 H-loop/switch region; other site 205918009858 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 205918009859 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918009860 TM-ABC transporter signature motif; other site 205918009861 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009862 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009863 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009864 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009865 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009866 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009867 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009868 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009869 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009870 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918009871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918009872 dimer interface [polypeptide binding]; other site 205918009873 phosphorylation site [posttranslational modification] 205918009874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918009875 ATP binding site [chemical binding]; other site 205918009876 Mg2+ binding site [ion binding]; other site 205918009877 G-X-G motif; other site 205918009878 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009879 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918009880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918009881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918009882 active site 205918009883 phosphorylation site [posttranslational modification] 205918009884 intermolecular recognition site; other site 205918009885 dimerization interface [polypeptide binding]; other site 205918009886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918009887 DNA binding site [nucleotide binding] 205918009888 MltA-interacting protein MipA; Region: MipA; cl01504 205918009889 hypothetical protein; Provisional; Region: PRK06184 205918009890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918009891 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 205918009892 dimer interface [polypeptide binding]; other site 205918009893 tetracycline repressor protein TetR; Provisional; Region: PRK13756 205918009894 Helix-turn-helix domains; Region: HTH; cl00088 205918009895 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 205918009896 amino acid transporter; Region: 2A0306; TIGR00909 205918009897 Spore germination protein; Region: Spore_permease; cl15802 205918009898 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009899 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009900 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009901 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009902 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009903 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009904 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009905 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009906 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009907 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009908 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009909 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918009910 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 205918009911 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 205918009912 Protein of unknown function DUF72; Region: DUF72; cl00777 205918009913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 205918009914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 205918009915 active site 205918009916 phosphorylation site [posttranslational modification] 205918009917 intermolecular recognition site; other site 205918009918 dimerization interface [polypeptide binding]; other site 205918009919 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 205918009920 GAF domain; Region: GAF; cl15785 205918009921 Phytochrome region; Region: PHY; pfam00360 205918009922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918009923 dimer interface [polypeptide binding]; other site 205918009924 phosphorylation site [posttranslational modification] 205918009925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918009926 ATP binding site [chemical binding]; other site 205918009927 Mg2+ binding site [ion binding]; other site 205918009928 G-X-G motif; other site 205918009929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 205918009930 Histidine kinase; Region: HisKA_2; cl06527 205918009931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918009932 Predicted dehydrogenase [General function prediction only]; Region: COG0579 205918009933 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 205918009934 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 205918009935 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 205918009936 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 205918009937 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 205918009938 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 205918009939 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 205918009940 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 205918009941 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 205918009942 XdhC Rossmann domain; Region: XdhC_C; pfam13478 205918009943 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 205918009944 Ligand binding site; other site 205918009945 metal-binding site 205918009946 Flavin Reductases; Region: FlaRed; cl00801 205918009947 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918009948 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 205918009949 NAD(P) binding site [chemical binding]; other site 205918009950 catalytic residues [active] 205918009951 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918009952 Helix-turn-helix domains; Region: HTH; cl00088 205918009953 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 205918009954 putative dimerization interface [polypeptide binding]; other site 205918009955 tartrate dehydrogenase; Provisional; Region: PRK08194 205918009956 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 205918009957 transcriptional activator TtdR; Provisional; Region: PRK09801 205918009958 Helix-turn-helix domains; Region: HTH; cl00088 205918009959 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 205918009960 putative effector binding pocket; other site 205918009961 putative dimerization interface [polypeptide binding]; other site 205918009962 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205918009963 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918009964 Walker A/P-loop; other site 205918009965 ATP binding site [chemical binding]; other site 205918009966 Q-loop/lid; other site 205918009967 ABC transporter signature motif; other site 205918009968 Walker B; other site 205918009969 D-loop; other site 205918009970 H-loop/switch region; other site 205918009971 TOBE domain; Region: TOBE_2; cl01440 205918009972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918009973 dimer interface [polypeptide binding]; other site 205918009974 conserved gate region; other site 205918009975 putative PBP binding loops; other site 205918009976 ABC-ATPase subunit interface; other site 205918009977 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009978 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009979 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009980 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009981 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009982 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009983 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918009984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918009985 dimer interface [polypeptide binding]; other site 205918009986 conserved gate region; other site 205918009987 putative PBP binding loops; other site 205918009988 ABC-ATPase subunit interface; other site 205918009989 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009990 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009991 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009992 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009993 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009994 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918009995 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 205918009996 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918009997 1 probable transmembrane helix predicted by TMHMM2.0 205918009998 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485 205918009999 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 205918010000 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 205918010001 dimerization interface [polypeptide binding]; other site 205918010002 active site 205918010003 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 205918010004 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 205918010005 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 205918010006 nudix motif; other site 205918010007 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918010008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918010009 DNA-binding site [nucleotide binding]; DNA binding site 205918010010 FCD domain; Region: FCD; cl11656 205918010011 Flavin Reductases; Region: FlaRed; cl00801 205918010012 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918010013 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 205918010014 NAD(P) binding site [chemical binding]; other site 205918010015 catalytic residues [active] 205918010016 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 205918010017 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918010018 Amino acid synthesis; Region: AA_synth; pfam06684 205918010019 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 205918010020 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 205918010021 NAD binding site [chemical binding]; other site 205918010022 catalytic Zn binding site [ion binding]; other site 205918010023 structural Zn binding site [ion binding]; other site 205918010024 short chain dehydrogenase; Provisional; Region: PRK06701 205918010025 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 205918010026 NAD binding site [chemical binding]; other site 205918010027 metal binding site [ion binding]; metal-binding site 205918010028 active site 205918010029 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918010030 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918010031 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918010032 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 205918010033 tetramerization interface [polypeptide binding]; other site 205918010034 NAD(P) binding site [chemical binding]; other site 205918010035 catalytic residues [active] 205918010036 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 205918010037 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918010038 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010039 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010040 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 205918010041 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 205918010042 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 205918010043 shikimate binding site; other site 205918010044 NAD(P) binding site [chemical binding]; other site 205918010045 Protein of unknown function, DUF480; Region: DUF480; cl01209 205918010046 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 205918010047 putative arabinose transporter; Provisional; Region: PRK03545 205918010048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918010049 putative substrate translocation pore; other site 205918010050 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010051 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010052 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010053 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010054 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010055 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010056 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010057 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010058 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010059 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010060 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010061 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010062 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 205918010063 Helix-turn-helix domains; Region: HTH; cl00088 205918010064 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 205918010065 putative dimerization interface [polypeptide binding]; other site 205918010066 Integral membrane protein TerC family; Region: TerC; cl10468 205918010067 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010068 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010069 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010070 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010071 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010072 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010073 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918010074 1 probable transmembrane helix predicted by TMHMM2.0 205918010075 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 205918010076 putative active site [active] 205918010077 1 probable transmembrane helix predicted by TMHMM2.0 205918010078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918010079 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918010080 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918010081 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205918010082 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 205918010083 NAD(P) binding site [chemical binding]; other site 205918010084 active site 205918010085 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 205918010086 nudix motif; other site 205918010087 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 205918010088 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 205918010089 putative NAD(P) binding site [chemical binding]; other site 205918010090 putative substrate binding site [chemical binding]; other site 205918010091 catalytic Zn binding site [ion binding]; other site 205918010092 structural Zn binding site [ion binding]; other site 205918010093 dimer interface [polypeptide binding]; other site 205918010094 GAF domain; Region: GAF_2; pfam13185 205918010095 GAF domain; Region: GAF; cl15785 205918010096 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 205918010097 GAF domain; Region: GAF; cl15785 205918010098 GAF domain; Region: GAF_2; pfam13185 205918010099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918010100 metal binding site [ion binding]; metal-binding site 205918010101 active site 205918010102 I-site; other site 205918010103 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918010104 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205918010105 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 205918010106 putative substrate binding site [chemical binding]; other site 205918010107 putative ATP binding site [chemical binding]; other site 205918010108 D-xylulose kinases, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 205918010109 N- and C-terminal domain interface [polypeptide binding]; other site 205918010110 D-xylulose kinase; Region: XylB; TIGR01312 205918010111 active site 205918010112 catalytic site [active] 205918010113 metal binding site [ion binding]; metal-binding site 205918010114 xylulose binding site [chemical binding]; other site 205918010115 ATP binding site [chemical binding]; other site 205918010116 putative homodimer interface [polypeptide binding]; other site 205918010117 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 205918010118 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 205918010119 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 205918010120 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 205918010121 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 205918010122 Walker A/P-loop; other site 205918010123 ATP binding site [chemical binding]; other site 205918010124 Q-loop/lid; other site 205918010125 ABC transporter signature motif; other site 205918010126 Walker B; other site 205918010127 D-loop; other site 205918010128 H-loop/switch region; other site 205918010129 TOBE domain; Region: TOBE_2; cl01440 205918010130 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205918010131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010132 dimer interface [polypeptide binding]; other site 205918010133 conserved gate region; other site 205918010134 ABC-ATPase subunit interface; other site 205918010135 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010136 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010137 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010138 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010139 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010140 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010142 dimer interface [polypeptide binding]; other site 205918010143 conserved gate region; other site 205918010144 putative PBP binding loops; other site 205918010145 ABC-ATPase subunit interface; other site 205918010146 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010147 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010148 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010149 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010150 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010151 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010152 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205918010153 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918010154 1 probable transmembrane helix predicted by TMHMM2.0 205918010155 Cupin domain; Region: Cupin_2; cl09118 205918010156 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918010157 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918010158 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918010159 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 205918010160 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 205918010161 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 205918010162 Response regulator receiver domain; Region: Response_reg; pfam00072 205918010163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010164 active site 205918010165 phosphorylation site [posttranslational modification] 205918010166 intermolecular recognition site; other site 205918010167 dimerization interface [polypeptide binding]; other site 205918010168 CHASE3 domain; Region: CHASE3; cl05000 205918010169 GAF domain; Region: GAF_2; pfam13185 205918010170 GAF domain; Region: GAF; cl15785 205918010171 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 205918010172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918010173 dimer interface [polypeptide binding]; other site 205918010174 phosphorylation site [posttranslational modification] 205918010175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918010176 ATP binding site [chemical binding]; other site 205918010177 Mg2+ binding site [ion binding]; other site 205918010178 G-X-G motif; other site 205918010179 Response regulator receiver domain; Region: Response_reg; pfam00072 205918010180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010181 active site 205918010182 phosphorylation site [posttranslational modification] 205918010183 intermolecular recognition site; other site 205918010184 dimerization interface [polypeptide binding]; other site 205918010185 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918010186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010187 active site 205918010188 phosphorylation site [posttranslational modification] 205918010189 intermolecular recognition site; other site 205918010190 dimerization interface [polypeptide binding]; other site 205918010191 Response regulator receiver domain; Region: Response_reg; pfam00072 205918010192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010193 active site 205918010194 phosphorylation site [posttranslational modification] 205918010195 intermolecular recognition site; other site 205918010196 dimerization interface [polypeptide binding]; other site 205918010197 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010198 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010199 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 205918010200 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 205918010201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918010202 CheB methylesterase; Region: CheB_methylest; pfam01339 205918010203 Response regulator receiver domain; Region: Response_reg; pfam00072 205918010204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010205 active site 205918010206 phosphorylation site [posttranslational modification] 205918010207 intermolecular recognition site; other site 205918010208 dimerization interface [polypeptide binding]; other site 205918010209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 205918010210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918010211 dimer interface [polypeptide binding]; other site 205918010212 phosphorylation site [posttranslational modification] 205918010213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918010214 ATP binding site [chemical binding]; other site 205918010215 Mg2+ binding site [ion binding]; other site 205918010216 G-X-G motif; other site 205918010217 Response regulator receiver domain; Region: Response_reg; pfam00072 205918010218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010219 active site 205918010220 phosphorylation site [posttranslational modification] 205918010221 intermolecular recognition site; other site 205918010222 dimerization interface [polypeptide binding]; other site 205918010223 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918010224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918010225 PAS fold; Region: PAS_3; pfam08447 205918010226 putative active site [active] 205918010227 heme pocket [chemical binding]; other site 205918010228 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 205918010229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918010230 dimer interface [polypeptide binding]; other site 205918010231 phosphorylation site [posttranslational modification] 205918010232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918010233 ATP binding site [chemical binding]; other site 205918010234 Mg2+ binding site [ion binding]; other site 205918010235 G-X-G motif; other site 205918010236 Response regulator receiver domain; Region: Response_reg; pfam00072 205918010237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918010238 active site 205918010239 phosphorylation site [posttranslational modification] 205918010240 intermolecular recognition site; other site 205918010241 dimerization interface [polypeptide binding]; other site 205918010242 circadian clock protein KaiC; Reviewed; Region: PRK09302 205918010243 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918010244 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918010245 Walker A motif; other site 205918010246 Walker A motif; other site 205918010247 ATP binding site [chemical binding]; other site 205918010248 Walker B motif; other site 205918010249 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 205918010250 Walker A motif; other site 205918010251 ATP binding site [chemical binding]; other site 205918010252 Walker B motif; other site 205918010253 enoyl-CoA hydratase; Provisional; Region: PRK06142 205918010254 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918010255 substrate binding site [chemical binding]; other site 205918010256 oxyanion hole (OAH) forming residues; other site 205918010257 trimer interface [polypeptide binding]; other site 205918010258 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 205918010259 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 205918010260 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 205918010261 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 205918010262 putative NADH binding site [chemical binding]; other site 205918010263 putative active site [active] 205918010264 nudix motif; other site 205918010265 putative metal binding site [ion binding]; other site 205918010266 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 205918010267 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010268 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010269 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010270 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010271 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010272 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010273 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 205918010274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918010275 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 205918010276 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 205918010277 classical (c) SDRs; Region: SDR_c; cd05233 205918010278 NAD(P) binding site [chemical binding]; other site 205918010279 active site 205918010280 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 205918010281 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 205918010282 putative active site [active] 205918010283 putative substrate binding site [chemical binding]; other site 205918010284 ATP binding site [chemical binding]; other site 205918010285 SCP-2 sterol transfer family; Region: SCP2; cl01225 205918010286 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205918010287 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 205918010288 catalytic core [active] 205918010289 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 205918010290 putative inner membrane peptidase; Provisional; Region: PRK11778 205918010291 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 205918010292 tandem repeat interface [polypeptide binding]; other site 205918010293 oligomer interface [polypeptide binding]; other site 205918010294 active site residues [active] 205918010295 1 probable transmembrane helix predicted by TMHMM2.0 205918010296 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 205918010297 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 205918010298 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 205918010299 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 205918010300 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324 205918010301 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 205918010302 putative ligand binding site [chemical binding]; other site 205918010303 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 205918010304 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 205918010305 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 205918010306 substrate binding pocket [chemical binding]; other site 205918010307 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 205918010308 B12 binding site [chemical binding]; other site 205918010309 cobalt ligand [ion binding]; other site 205918010310 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 205918010311 OpgC protein; Region: OpgC_C; cl00792 205918010312 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010313 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010314 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010315 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010316 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010317 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010318 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010319 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010320 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010321 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 205918010322 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 205918010323 NifU-like domain; Region: NifU; cl00484 205918010324 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 205918010325 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918010326 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918010327 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 205918010328 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 205918010329 carboxyltransferase (CT) interaction site; other site 205918010330 biotinylation site [posttranslational modification]; other site 205918010331 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 205918010332 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918010333 substrate binding site [chemical binding]; other site 205918010334 oxyanion hole (OAH) forming residues; other site 205918010335 trimer interface [polypeptide binding]; other site 205918010336 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 205918010337 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 205918010338 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 205918010339 isovaleryl-CoA dehydrogenase; Region: PLN02519 205918010340 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 205918010341 substrate binding site [chemical binding]; other site 205918010342 FAD binding site [chemical binding]; other site 205918010343 catalytic base [active] 205918010344 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 205918010345 active site 205918010346 catalytic residues [active] 205918010347 metal binding site [ion binding]; metal-binding site 205918010348 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 205918010349 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 205918010350 DNA binding residues [nucleotide binding] 205918010351 putative dimer interface [polypeptide binding]; other site 205918010352 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 205918010353 Helix-turn-helix domains; Region: HTH; cl00088 205918010354 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 205918010355 substrate binding pocket [chemical binding]; other site 205918010356 dimerization interface [polypeptide binding]; other site 205918010357 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918010358 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 205918010359 FAD binding site [chemical binding]; other site 205918010360 substrate binding site [chemical binding]; other site 205918010361 catalytic base [active] 205918010362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918010363 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918010364 ligand binding site [chemical binding]; other site 205918010365 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 205918010366 putative catalytic site [active] 205918010367 putative phosphate binding site [ion binding]; other site 205918010368 active site 205918010369 metal binding site A [ion binding]; metal-binding site 205918010370 DNA binding site [nucleotide binding] 205918010371 putative AP binding site [nucleotide binding]; other site 205918010372 putative metal binding site B [ion binding]; other site 205918010373 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918010374 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 205918010375 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 205918010376 Surface antigen; Region: Bac_surface_Ag; cl03097 205918010377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 205918010378 Family of unknown function (DUF490); Region: DUF490; pfam04357 205918010379 1 probable transmembrane helix predicted by TMHMM2.0 205918010380 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918010381 Helix-turn-helix domains; Region: HTH; cl00088 205918010382 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 205918010383 putative effector binding pocket; other site 205918010384 putative dimerization interface [polypeptide binding]; other site 205918010385 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 205918010386 dimer interface [polypeptide binding]; other site 205918010387 catalytic triad [active] 205918010388 peroxidatic and resolving cysteines [active] 205918010389 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 205918010390 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918010391 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918010392 1 probable transmembrane helix predicted by TMHMM2.0 205918010393 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 205918010394 Protein export membrane protein; Region: SecD_SecF; cl14618 205918010395 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010396 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010397 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010398 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010399 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010400 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010401 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010402 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010403 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010404 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010405 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010406 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010407 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 205918010408 Protein export membrane protein; Region: SecD_SecF; cl14618 205918010409 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010410 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010411 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010412 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010413 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010414 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010415 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010416 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010417 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010418 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918010419 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918010420 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 205918010421 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 205918010422 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 205918010423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918010424 metal binding site [ion binding]; metal-binding site 205918010425 active site 205918010426 I-site; other site 205918010427 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918010428 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010429 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010430 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010431 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010432 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010433 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010434 short chain dehydrogenase; Provisional; Region: PRK06123 205918010435 classical (c) SDRs; Region: SDR_c; cd05233 205918010436 NAD(P) binding site [chemical binding]; other site 205918010437 active site 205918010438 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 205918010439 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 205918010440 active site 205918010441 homodimer interface [polypeptide binding]; other site 205918010442 catalytic site [active] 205918010443 acceptor binding site [chemical binding]; other site 205918010444 trehalose synthase; Region: treS_nterm; TIGR02456 205918010445 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 205918010446 active site 205918010447 catalytic site [active] 205918010448 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 205918010449 glycogen branching enzyme; Provisional; Region: PRK05402 205918010450 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 205918010451 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 205918010452 active site 205918010453 catalytic site [active] 205918010454 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 205918010455 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 205918010456 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 205918010457 major facilitator superfamily transporter; Provisional; Region: PRK05122 205918010458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918010459 putative substrate translocation pore; other site 205918010460 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010461 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010462 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010463 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010464 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010465 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010466 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010467 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010468 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010469 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010470 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010471 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010472 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 205918010473 1 probable transmembrane helix predicted by TMHMM2.0 205918010474 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 205918010475 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918010476 Walker A/P-loop; other site 205918010477 ATP binding site [chemical binding]; other site 205918010478 Q-loop/lid; other site 205918010479 ABC transporter signature motif; other site 205918010480 Walker B; other site 205918010481 D-loop; other site 205918010482 H-loop/switch region; other site 205918010483 ABC transporter; Region: ABC_tran_2; pfam12848 205918010484 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 205918010485 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 205918010486 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 205918010487 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918010488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918010489 Coenzyme A binding pocket [chemical binding]; other site 205918010490 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918010491 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 205918010492 putative C-terminal domain interface [polypeptide binding]; other site 205918010493 putative GSH binding site (G-site) [chemical binding]; other site 205918010494 putative dimer interface [polypeptide binding]; other site 205918010495 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 205918010496 putative N-terminal domain interface [polypeptide binding]; other site 205918010497 putative dimer interface [polypeptide binding]; other site 205918010498 putative substrate binding pocket (H-site) [chemical binding]; other site 205918010499 Cyclophilin-like; Region: Cyclophil_like; cl00950 205918010500 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 205918010501 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918010502 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918010503 substrate binding pocket [chemical binding]; other site 205918010504 membrane-bound complex binding site; other site 205918010505 hinge residues; other site 205918010506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010507 dimer interface [polypeptide binding]; other site 205918010508 conserved gate region; other site 205918010509 putative PBP binding loops; other site 205918010510 ABC-ATPase subunit interface; other site 205918010511 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010512 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010513 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010514 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010515 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010516 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918010517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010518 dimer interface [polypeptide binding]; other site 205918010519 conserved gate region; other site 205918010520 putative PBP binding loops; other site 205918010521 ABC-ATPase subunit interface; other site 205918010522 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918010523 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918010524 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918010525 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918010526 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 205918010527 Walker A/P-loop; other site 205918010528 ATP binding site [chemical binding]; other site 205918010529 Q-loop/lid; other site 205918010530 ABC transporter signature motif; other site 205918010531 Walker B; other site 205918010532 D-loop; other site 205918010533 H-loop/switch region; other site 205918010534 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 205918010535 homotrimer interaction site [polypeptide binding]; other site 205918010536 putative active site [active] 205918010537 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205918010538 Helix-turn-helix domains; Region: HTH; cl00088 205918010539 Bacterial transcriptional regulator; Region: IclR; pfam01614 205918010540 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 205918010541 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 205918010542 dimer interface [polypeptide binding]; other site 205918010543 active site 205918010544 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918010545 substrate binding site [chemical binding]; other site 205918010546 catalytic residue [active] 205918010547 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205918010548 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 205918010549 substrate binding site [chemical binding]; other site 205918010550 ATP binding site [chemical binding]; other site 205918010551 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 205918010552 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 205918010553 Family description; Region: UvrD_C_2; cl15862 205918010554 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 205918010555 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 205918010556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918010557 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 205918010558 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 205918010559 Walker A/P-loop; other site 205918010560 ATP binding site [chemical binding]; other site 205918010561 Q-loop/lid; other site 205918010562 ABC transporter signature motif; other site 205918010563 Walker B; other site 205918010564 D-loop; other site 205918010565 H-loop/switch region; other site 205918010566 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 205918010567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010568 dimer interface [polypeptide binding]; other site 205918010569 conserved gate region; other site 205918010570 putative PBP binding loops; other site 205918010571 ABC-ATPase subunit interface; other site 205918010572 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010573 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010574 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010575 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010576 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010577 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010578 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918010579 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918010580 membrane-bound complex binding site; other site 205918010581 1 probable transmembrane helix predicted by TMHMM2.0 205918010582 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 205918010583 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918010584 active site 205918010585 catalytic tetrad [active] 205918010586 LexA repressor; Provisional; Region: PRK12423 205918010587 Helix-turn-helix domains; Region: HTH; cl00088 205918010588 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918010589 Catalytic site [active] 205918010590 Cell division inhibitor SulA; Region: SulA; cl01880 205918010591 DNA Polymerase Y-family; Region: PolY_like; cd03468 205918010592 active site 205918010593 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 205918010594 DNA binding site [nucleotide binding] 205918010595 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 205918010596 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 205918010597 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 205918010598 generic binding surface I; other site 205918010599 generic binding surface II; other site 205918010600 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 205918010601 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 205918010602 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010603 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010604 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 205918010605 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 205918010606 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918010607 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205918010608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918010609 Coenzyme A binding pocket [chemical binding]; other site 205918010610 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 205918010611 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 205918010612 NodB motif; other site 205918010613 active site 205918010614 catalytic site [active] 205918010615 metal binding site [ion binding]; metal-binding site 205918010616 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 205918010617 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 205918010618 active site 205918010619 citrate-proton symporter; Provisional; Region: PRK15075 205918010620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918010621 putative substrate translocation pore; other site 205918010622 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010623 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010624 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010625 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010626 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010627 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010628 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010629 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010630 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010631 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010632 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010633 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918010634 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918010635 Helix-turn-helix domains; Region: HTH; cl00088 205918010636 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918010637 dimerization interface [polypeptide binding]; other site 205918010638 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918010639 Helix-turn-helix domains; Region: HTH; cl00088 205918010640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918010641 dimerization interface [polypeptide binding]; other site 205918010642 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 205918010643 FAD binding domain; Region: FAD_binding_4; pfam01565 205918010644 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 205918010645 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 205918010646 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918010647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918010648 metal binding site [ion binding]; metal-binding site 205918010649 active site 205918010650 I-site; other site 205918010651 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010652 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010653 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010654 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010655 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010656 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010657 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 205918010658 Helix-turn-helix domains; Region: HTH; cl00088 205918010659 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918010660 dimerization interface [polypeptide binding]; other site 205918010661 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 205918010662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918010663 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205918010664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010665 dimer interface [polypeptide binding]; other site 205918010666 conserved gate region; other site 205918010667 putative PBP binding loops; other site 205918010668 ABC-ATPase subunit interface; other site 205918010669 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010670 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010671 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010672 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010673 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010674 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918010675 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 205918010676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918010677 dimer interface [polypeptide binding]; other site 205918010678 conserved gate region; other site 205918010679 putative PBP binding loops; other site 205918010680 ABC-ATPase subunit interface; other site 205918010681 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010682 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010683 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010684 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010685 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010686 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 205918010687 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918010688 Walker A/P-loop; other site 205918010689 ATP binding site [chemical binding]; other site 205918010690 Q-loop/lid; other site 205918010691 ABC transporter signature motif; other site 205918010692 Walker B; other site 205918010693 D-loop; other site 205918010694 H-loop/switch region; other site 205918010695 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918010696 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918010697 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 205918010698 Walker A/P-loop; other site 205918010699 ATP binding site [chemical binding]; other site 205918010700 Q-loop/lid; other site 205918010701 ABC transporter signature motif; other site 205918010702 Walker B; other site 205918010703 D-loop; other site 205918010704 H-loop/switch region; other site 205918010705 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918010706 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 205918010707 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205918010708 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 205918010709 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 205918010710 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 205918010711 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 205918010712 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 205918010713 active site 205918010714 metal binding site [ion binding]; metal-binding site 205918010715 hexamer interface [polypeptide binding]; other site 205918010716 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 205918010717 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918010718 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918010719 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918010720 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918010721 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 205918010722 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 205918010723 dimer interface [polypeptide binding]; other site 205918010724 active site 205918010725 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918010726 catalytic residues [active] 205918010727 substrate binding site [chemical binding]; other site 205918010728 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 205918010729 metal binding triad [ion binding]; metal-binding site 205918010730 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918010731 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 205918010732 inhibitor-cofactor binding pocket; inhibition site 205918010733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918010734 catalytic residue [active] 205918010735 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 205918010736 hydrophobic ligand binding site; other site 205918010737 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205918010738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918010739 NAD(P) binding site [chemical binding]; other site 205918010740 active site 205918010741 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 205918010742 Fatty acid desaturase; Region: FA_desaturase; pfam00487 205918010743 putative di-iron ligands [ion binding]; other site 205918010744 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 205918010745 1 probable transmembrane helix predicted by TMHMM2.0 205918010746 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 205918010747 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 205918010748 trimer interface [polypeptide binding]; other site 205918010749 active site 205918010750 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 205918010751 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 205918010752 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 205918010753 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918010754 Walker A/P-loop; other site 205918010755 ATP binding site [chemical binding]; other site 205918010756 ABC transporter signature motif; other site 205918010757 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918010758 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 205918010759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918010760 active site 205918010761 motif I; other site 205918010762 motif II; other site 205918010763 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918010764 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918010765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918010766 DNA-binding site [nucleotide binding]; DNA binding site 205918010767 DAK2 domain; Region: Dak2; cl03685 205918010768 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 205918010769 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 205918010770 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 205918010771 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 205918010772 putative NAD(P) binding site [chemical binding]; other site 205918010773 catalytic Zn binding site [ion binding]; other site 205918010774 structural Zn binding site [ion binding]; other site 205918010775 short chain dehydrogenase; Provisional; Region: PRK06841 205918010776 classical (c) SDRs; Region: SDR_c; cd05233 205918010777 NAD(P) binding site [chemical binding]; other site 205918010778 active site 205918010779 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 205918010780 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 205918010781 putative ligand binding site [chemical binding]; other site 205918010782 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918010783 TM-ABC transporter signature motif; other site 205918010784 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010785 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010786 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010787 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010788 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010789 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010790 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010791 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010792 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 205918010793 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 205918010794 Walker A/P-loop; other site 205918010795 ATP binding site [chemical binding]; other site 205918010796 Q-loop/lid; other site 205918010797 ABC transporter signature motif; other site 205918010798 Walker B; other site 205918010799 D-loop; other site 205918010800 H-loop/switch region; other site 205918010801 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 205918010802 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 205918010803 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 205918010804 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918010805 DNA binding residues [nucleotide binding] 205918010806 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 205918010807 UbiA prenyltransferase family; Region: UbiA; cl00337 205918010808 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 205918010809 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 205918010810 Trp docking motif [polypeptide binding]; other site 205918010811 putative active site [active] 205918010812 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010813 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010814 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010815 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010816 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010817 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918010818 DNA binding residues [nucleotide binding] 205918010819 dimerization interface [polypeptide binding]; other site 205918010820 peptide synthase; Provisional; Region: PRK12467 205918010821 AMP-binding enzyme; Region: AMP-binding; cl15778 205918010822 AMP-binding enzyme; Region: AMP-binding; cl15778 205918010823 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918010824 peptide synthase; Provisional; Region: PRK12467 205918010825 AMP-binding enzyme; Region: AMP-binding; cl15778 205918010826 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918010827 AMP-binding enzyme; Region: AMP-binding; cl15778 205918010828 AMP-binding enzyme; Region: AMP-binding; cl15778 205918010829 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918010830 peptide synthase; Provisional; Region: PRK12467 205918010831 AMP-binding enzyme; Region: AMP-binding; cl15778 205918010832 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918010833 peptide synthase; Provisional; Region: PRK12467 205918010834 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918010835 AMP-binding enzyme; Region: AMP-binding; cl15778 205918010836 AMP-binding enzyme; Region: AMP-binding; cl15778 205918010837 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918010838 AMP-binding enzyme; Region: AMP-binding; cl15778 205918010839 AMP-binding enzyme; Region: AMP-binding; cl15778 205918010840 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918010841 peptide synthase; Provisional; Region: PRK12467 205918010842 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918010843 AMP-binding enzyme; Region: AMP-binding; cl15778 205918010844 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918010845 AMP-binding enzyme; Region: AMP-binding; cl15778 205918010846 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918010847 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918010848 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918010849 Helix-turn-helix domains; Region: HTH; cl00088 205918010850 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 205918010851 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918010852 NAD(P) binding site [chemical binding]; other site 205918010853 catalytic residues [active] 205918010854 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 205918010855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918010856 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 205918010857 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 205918010858 FecR protein; Region: FecR; pfam04773 205918010859 Secretin and TonB N terminus short domain; Region: STN; cl06624 205918010860 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918010861 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918010862 N-terminal plug; other site 205918010863 ligand-binding site [chemical binding]; other site 205918010864 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 205918010865 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918010866 inhibitor-cofactor binding pocket; inhibition site 205918010867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918010868 catalytic residue [active] 205918010869 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 205918010870 IucA / IucC family; Region: IucA_IucC; pfam04183 205918010871 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 205918010872 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 205918010873 dimer interface [polypeptide binding]; other site 205918010874 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 205918010875 active site 205918010876 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918010877 catalytic residues [active] 205918010878 substrate binding site [chemical binding]; other site 205918010879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918010880 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205918010881 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010882 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010883 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010884 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010885 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010886 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010887 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010888 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010889 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010890 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010891 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010892 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010893 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010894 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918010895 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 205918010896 IucA / IucC family; Region: IucA_IucC; pfam04183 205918010897 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 205918010898 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 205918010899 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 205918010900 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 205918010901 IucA / IucC family; Region: IucA_IucC; pfam04183 205918010902 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 205918010903 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 205918010904 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 205918010905 siderophore binding site; other site 205918010906 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918010907 ABC-ATPase subunit interface; other site 205918010908 dimer interface [polypeptide binding]; other site 205918010909 putative PBP binding regions; other site 205918010910 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010911 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010912 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010913 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010914 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010915 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010916 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010917 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010918 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918010919 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918010920 ABC-ATPase subunit interface; other site 205918010921 dimer interface [polypeptide binding]; other site 205918010922 putative PBP binding regions; other site 205918010923 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010924 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010925 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010926 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010927 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010928 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010929 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010930 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918010931 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 205918010932 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 205918010933 Walker A/P-loop; other site 205918010934 ATP binding site [chemical binding]; other site 205918010935 Q-loop/lid; other site 205918010936 ABC transporter signature motif; other site 205918010937 Walker B; other site 205918010938 D-loop; other site 205918010939 H-loop/switch region; other site 205918010940 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 205918010941 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 205918010942 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 205918010943 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 205918010944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918010945 putative active site [active] 205918010946 heme pocket [chemical binding]; other site 205918010947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918010948 PAS domain; Region: PAS_9; pfam13426 205918010949 putative active site [active] 205918010950 heme pocket [chemical binding]; other site 205918010951 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918010952 dimer interface [polypeptide binding]; other site 205918010953 putative CheW interface [polypeptide binding]; other site 205918010954 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918010955 metal binding site [ion binding]; metal-binding site 205918010956 active site 205918010957 I-site; other site 205918010958 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918010959 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010960 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918010961 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 205918010962 DNA helicase, putative; Region: TIGR00376 205918010963 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918010964 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918010965 Family description; Region: UvrD_C_2; cl15862 205918010966 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 205918010967 putative active site [active] 205918010968 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 205918010969 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 205918010970 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 205918010971 putative active site [active] 205918010972 putative metal binding site [ion binding]; other site 205918010973 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918010974 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918010975 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918010976 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 205918010977 Helix-turn-helix domains; Region: HTH; cl00088 205918010978 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918010979 DNA binding residues [nucleotide binding] 205918010980 dimerization interface [polypeptide binding]; other site 205918010981 macrolide transporter subunit MacA; Provisional; Region: PRK11578 205918010982 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918010983 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918010984 1 probable transmembrane helix predicted by TMHMM2.0 205918010985 LysE type translocator; Region: LysE; cl00565 205918010986 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010987 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010988 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010989 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010990 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918010991 Helix-turn-helix domains; Region: HTH; cl00088 205918010992 Winged helix-turn helix; Region: HTH_29; pfam13551 205918010993 Helix-turn-helix domains; Region: HTH; cl00088 205918010994 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918010995 Helix-turn-helix domains; Region: HTH; cl00088 205918010996 peptide synthase; Provisional; Region: PRK12467 205918010997 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918010998 AMP-binding enzyme; Region: AMP-binding; cl15778 205918010999 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011000 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011001 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011002 peptide synthase; Provisional; Region: PRK12316 205918011003 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011004 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011005 peptide synthase; Provisional; Region: PRK12467 205918011006 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011007 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011008 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011009 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011010 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011011 peptide synthase; Provisional; Region: PRK12467 205918011012 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011013 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011014 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011015 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011016 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011017 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011018 peptide synthase; Provisional; Region: PRK12467 205918011019 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011020 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011021 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011022 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011023 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918011024 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918011025 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 205918011026 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 205918011027 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011028 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011029 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011030 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 205918011031 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 205918011032 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205918011033 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 205918011034 Walker A/P-loop; other site 205918011035 ATP binding site [chemical binding]; other site 205918011036 Q-loop/lid; other site 205918011037 ABC transporter signature motif; other site 205918011038 Walker B; other site 205918011039 D-loop; other site 205918011040 H-loop/switch region; other site 205918011041 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011042 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011043 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011044 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011045 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011046 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011047 peptide synthase; Provisional; Region: PRK12467 205918011048 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011049 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011050 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011051 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011052 peptide synthase; Provisional; Region: PRK12467 205918011053 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011054 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011055 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011056 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011057 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011058 peptide synthase; Provisional; Region: PRK12316 205918011059 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011060 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011061 peptide synthase; Provisional; Region: PRK12467 205918011062 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011063 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011064 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011065 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011066 peptide synthase; Provisional; Region: PRK12467 205918011067 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011068 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011069 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011070 peptide synthase; Provisional; Region: PRK12467 205918011071 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011072 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011073 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011074 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011075 peptide synthase; Provisional; Region: PRK12316 205918011076 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011077 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011078 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011079 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011080 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011081 peptide synthase; Provisional; Region: PRK12467 205918011082 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011083 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011084 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011085 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011086 peptide synthase; Provisional; Region: PRK12467 205918011087 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011088 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011089 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011090 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011091 peptide synthase; Provisional; Region: PRK12467 205918011092 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011093 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011094 peptide synthase; Provisional; Region: PRK12316 205918011095 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011096 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011097 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011098 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011099 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011100 peptide synthase; Provisional; Region: PRK12467 205918011101 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011102 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011103 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011104 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011105 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011106 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011107 peptide synthase; Provisional; Region: PRK12467 205918011108 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918011109 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011110 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011111 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918011112 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918011113 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918011114 macrolide transporter subunit MacA; Provisional; Region: PRK11578 205918011115 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918011116 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918011117 1 probable transmembrane helix predicted by TMHMM2.0 205918011118 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 205918011119 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205918011120 Walker A/P-loop; other site 205918011121 ATP binding site [chemical binding]; other site 205918011122 Q-loop/lid; other site 205918011123 ABC transporter signature motif; other site 205918011124 Walker B; other site 205918011125 D-loop; other site 205918011126 H-loop/switch region; other site 205918011127 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205918011128 FtsX-like permease family; Region: FtsX; cl15850 205918011129 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011130 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011131 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011132 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011133 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011134 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918011135 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 205918011136 inhibitor-cofactor binding pocket; inhibition site 205918011137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918011138 catalytic residue [active] 205918011139 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918011140 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918011141 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918011142 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 205918011143 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011144 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011145 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011146 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011147 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011148 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011149 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011150 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011151 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011152 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011153 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011154 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011155 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 205918011156 metal ion-dependent adhesion site (MIDAS); other site 205918011157 1 probable transmembrane helix predicted by TMHMM2.0 205918011158 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205918011159 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 205918011160 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011161 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011162 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 205918011163 1 probable transmembrane helix predicted by TMHMM2.0 205918011164 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011165 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011166 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011167 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205918011168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918011169 Walker A/P-loop; other site 205918011170 ATP binding site [chemical binding]; other site 205918011171 Q-loop/lid; other site 205918011172 ABC transporter signature motif; other site 205918011173 Walker B; other site 205918011174 D-loop; other site 205918011175 H-loop/switch region; other site 205918011176 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 205918011177 metal ion-dependent adhesion site (MIDAS); other site 205918011178 1 probable transmembrane helix predicted by TMHMM2.0 205918011179 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 205918011180 Virulence factor SrfB; Region: SrfB; pfam07520 205918011181 1 probable transmembrane helix predicted by TMHMM2.0 205918011182 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918011183 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 205918011184 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 205918011185 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918011186 dimerization interface [polypeptide binding]; other site 205918011187 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918011188 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918011189 dimer interface [polypeptide binding]; other site 205918011190 putative CheW interface [polypeptide binding]; other site 205918011191 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011192 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011193 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 205918011194 TspO/MBR family; Region: TspO_MBR; cl01379 205918011195 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011196 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011197 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011198 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011199 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011200 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918011201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918011202 1 probable transmembrane helix predicted by TMHMM2.0 205918011203 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918011204 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 205918011205 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 205918011206 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011207 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011208 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011209 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011210 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 205918011211 nudix motif; other site 205918011212 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 205918011213 active site 205918011214 substrate binding site [chemical binding]; other site 205918011215 ATP binding site [chemical binding]; other site 205918011216 AAA domain; Region: AAA_13; pfam13166 205918011217 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 205918011218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918011219 FeS/SAM binding site; other site 205918011220 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 205918011221 HEXXH motif domain; Region: mod_HExxH; TIGR04267 205918011222 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 205918011223 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918011224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918011225 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 205918011226 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918011227 UbiA prenyltransferase family; Region: UbiA; cl00337 205918011228 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011229 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011230 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011231 Helix-turn-helix domains; Region: HTH; cl00088 205918011232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918011233 putative transposase OrfB; Reviewed; Region: PHA02517 205918011234 HTH-like domain; Region: HTH_21; pfam13276 205918011235 Integrase core domain; Region: rve; cl01316 205918011236 Integrase core domain; Region: rve_3; cl15866 205918011237 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 205918011238 dimer interface [polypeptide binding]; other site 205918011239 FMN binding site [chemical binding]; other site 205918011240 NADPH bind site [chemical binding]; other site 205918011241 Abortive infection C-terminus; Region: Abi_C; pfam14355 205918011242 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 205918011243 Restriction endonuclease; Region: Mrr_cat; cl00516 205918011244 Domain of unknown function (DUF955); Region: DUF955; cl01076 205918011245 putative alcohol dehydrogenase; Provisional; Region: PRK09860 205918011246 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011247 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011248 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 205918011249 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 205918011250 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686 205918011251 nudix motif; other site 205918011252 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 205918011253 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 205918011254 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 205918011255 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 205918011256 catalytic residues [active] 205918011257 catalytic nucleophile [active] 205918011258 Presynaptic Site I dimer interface [polypeptide binding]; other site 205918011259 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 205918011260 Synaptic Flat tetramer interface [polypeptide binding]; other site 205918011261 Synaptic Site I dimer interface [polypeptide binding]; other site 205918011262 DNA binding site [nucleotide binding] 205918011263 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 205918011264 DNA-binding interface [nucleotide binding]; DNA binding site 205918011265 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: APH; cd05150 205918011266 Phosphotransferase enzyme family; Region: APH; pfam01636 205918011267 active site 205918011268 ATP binding site [chemical binding]; other site 205918011269 antibiotic binding site [chemical binding]; other site 205918011270 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918011271 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918011272 Helix-turn-helix domains; Region: HTH; cl00088 205918011273 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 205918011274 putative dimerization interface [polypeptide binding]; other site 205918011275 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 205918011276 Citrate transporter; Region: CitMHS; pfam03600 205918011277 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011278 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011279 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011280 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011281 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011282 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011283 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011284 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011285 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011286 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011287 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011288 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 205918011289 transcriptional regulator NanR; Provisional; Region: PRK03837 205918011290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918011291 DNA-binding site [nucleotide binding]; DNA binding site 205918011292 FCD domain; Region: FCD; cl11656 205918011293 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 205918011294 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918011295 Walker A/P-loop; other site 205918011296 ATP binding site [chemical binding]; other site 205918011297 Q-loop/lid; other site 205918011298 ABC transporter signature motif; other site 205918011299 Walker B; other site 205918011300 D-loop; other site 205918011301 H-loop/switch region; other site 205918011302 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918011303 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 205918011304 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918011305 Walker A/P-loop; other site 205918011306 ATP binding site [chemical binding]; other site 205918011307 Q-loop/lid; other site 205918011308 ABC transporter signature motif; other site 205918011309 Walker B; other site 205918011310 D-loop; other site 205918011311 H-loop/switch region; other site 205918011312 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918011313 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 205918011314 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205918011315 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205918011316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918011317 dimer interface [polypeptide binding]; other site 205918011318 conserved gate region; other site 205918011319 putative PBP binding loops; other site 205918011320 ABC-ATPase subunit interface; other site 205918011321 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011322 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011323 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011324 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011325 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011326 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918011327 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 205918011328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918011329 dimer interface [polypeptide binding]; other site 205918011330 conserved gate region; other site 205918011331 putative PBP binding loops; other site 205918011332 ABC-ATPase subunit interface; other site 205918011333 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011334 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011335 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011336 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011337 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 205918011338 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 205918011339 Cache domain; Region: Cache_1; pfam02743 205918011340 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 205918011341 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918011342 dimerization interface [polypeptide binding]; other site 205918011343 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918011344 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918011345 dimer interface [polypeptide binding]; other site 205918011346 putative CheW interface [polypeptide binding]; other site 205918011347 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011348 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011349 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 205918011350 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011351 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011352 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011353 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011354 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011355 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011356 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011357 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011358 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011359 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011360 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011361 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011362 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918011363 Amidinotransferase; Region: Amidinotransf; cl12043 205918011364 ornithine carbamoyltransferase; Validated; Region: PRK02102 205918011365 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 205918011366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918011367 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 205918011368 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 205918011369 putative substrate binding site [chemical binding]; other site 205918011370 nucleotide binding site [chemical binding]; other site 205918011371 nucleotide binding site [chemical binding]; other site 205918011372 homodimer interface [polypeptide binding]; other site 205918011373 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 205918011374 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 205918011375 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 205918011376 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 205918011377 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011378 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011379 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011380 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011381 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011382 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011383 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011384 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 205918011385 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 205918011386 inhibitor-cofactor binding pocket; inhibition site 205918011387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918011388 catalytic residue [active] 205918011389 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 205918011390 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 205918011391 Ligand binding site; other site 205918011392 Putative Catalytic site; other site 205918011393 DXD motif; other site 205918011394 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011395 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011396 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 205918011397 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 205918011398 active site 205918011399 substrate binding site [chemical binding]; other site 205918011400 cosubstrate binding site; other site 205918011401 catalytic site [active] 205918011402 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 205918011403 active site 205918011404 hexamer interface [polypeptide binding]; other site 205918011405 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 205918011406 NAD binding site [chemical binding]; other site 205918011407 substrate binding site [chemical binding]; other site 205918011408 active site 205918011409 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 205918011410 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 205918011411 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 205918011412 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 205918011413 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011414 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011415 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011416 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011417 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011418 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011419 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011420 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011421 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011422 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011423 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011424 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 205918011425 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011426 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011427 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918011428 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 205918011429 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011430 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011431 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011432 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011433 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 205918011434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918011435 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 205918011436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918011437 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 205918011438 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011439 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011440 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011441 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011442 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011443 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011444 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011445 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011446 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011447 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 205918011448 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 205918011449 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 205918011450 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 205918011451 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011452 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011453 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011454 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011455 histidine kinase; Provisional; Region: PRK13557 205918011456 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918011457 putative active site [active] 205918011458 heme pocket [chemical binding]; other site 205918011459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918011460 dimer interface [polypeptide binding]; other site 205918011461 phosphorylation site [posttranslational modification] 205918011462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918011463 ATP binding site [chemical binding]; other site 205918011464 Mg2+ binding site [ion binding]; other site 205918011465 G-X-G motif; other site 205918011466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918011467 active site 205918011468 phosphorylation site [posttranslational modification] 205918011469 intermolecular recognition site; other site 205918011470 dimerization interface [polypeptide binding]; other site 205918011471 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 205918011472 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 205918011473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918011474 UDP-galactopyranose mutase; Region: GLF; pfam03275 205918011475 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 205918011476 putative homodimer interface [polypeptide binding]; other site 205918011477 UDP-glucose 4-epimerase; Region: PLN02240 205918011478 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 205918011479 NAD binding site [chemical binding]; other site 205918011480 homodimer interface [polypeptide binding]; other site 205918011481 active site 205918011482 substrate binding site [chemical binding]; other site 205918011483 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 205918011484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918011485 non-specific DNA binding site [nucleotide binding]; other site 205918011486 salt bridge; other site 205918011487 sequence-specific DNA binding site [nucleotide binding]; other site 205918011488 Cupin domain; Region: Cupin_2; cl09118 205918011489 Peptidase C26; Region: Peptidase_C26; pfam07722 205918011490 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 205918011491 catalytic triad [active] 205918011492 Helix-turn-helix domains; Region: HTH; cl00088 205918011493 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918011494 dimerization interface [polypeptide binding]; other site 205918011495 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 205918011496 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 205918011497 iron-sulfur cluster [ion binding]; other site 205918011498 [2Fe-2S] cluster binding site [ion binding]; other site 205918011499 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 205918011500 alpha subunit interface [polypeptide binding]; other site 205918011501 active site 205918011502 substrate binding site [chemical binding]; other site 205918011503 Fe binding site [ion binding]; other site 205918011504 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 205918011505 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 205918011506 FMN-binding pocket [chemical binding]; other site 205918011507 flavin binding motif; other site 205918011508 phosphate binding motif [ion binding]; other site 205918011509 beta-alpha-beta structure motif; other site 205918011510 NAD binding pocket [chemical binding]; other site 205918011511 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205918011512 catalytic loop [active] 205918011513 iron binding site [ion binding]; other site 205918011514 Transcriptional regulators [Transcription]; Region: FadR; COG2186 205918011515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918011516 DNA-binding site [nucleotide binding]; DNA binding site 205918011517 FCD domain; Region: FCD; cl11656 205918011518 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 205918011519 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918011520 metal binding site [ion binding]; metal-binding site 205918011521 active site 205918011522 I-site; other site 205918011523 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918011524 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011525 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011526 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011527 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011528 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011529 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 205918011530 Helix-turn-helix domains; Region: HTH; cl00088 205918011531 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 205918011532 putative dimerization interface [polypeptide binding]; other site 205918011533 putative substrate binding pocket [chemical binding]; other site 205918011534 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 205918011535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918011536 D-galactonate transporter; Region: 2A0114; TIGR00893 205918011537 putative substrate translocation pore; other site 205918011538 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011539 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011540 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011541 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011542 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011543 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011544 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011545 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011546 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011547 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011548 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011549 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011550 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 205918011551 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 205918011552 active site 205918011553 tetramer interface [polypeptide binding]; other site 205918011554 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 205918011555 Major royal jelly protein; Region: MRJP; pfam03022 205918011556 1 probable transmembrane helix predicted by TMHMM2.0 205918011557 Helix-turn-helix domains; Region: HTH; cl00088 205918011558 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 205918011559 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 205918011560 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 205918011561 1 probable transmembrane helix predicted by TMHMM2.0 205918011562 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 205918011563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918011564 Helix-turn-helix domains; Region: HTH; cl00088 205918011565 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 205918011566 putative substrate binding pocket [chemical binding]; other site 205918011567 dimerization interface [polypeptide binding]; other site 205918011568 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 205918011569 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 205918011570 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 205918011571 dimer interface [polypeptide binding]; other site 205918011572 active site 205918011573 feruloyl-CoA synthase; Reviewed; Region: PRK08180 205918011574 AMP-binding enzyme; Region: AMP-binding; cl15778 205918011575 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918011576 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 205918011577 NAD(P) binding site [chemical binding]; other site 205918011578 catalytic residues [active] 205918011579 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 205918011580 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918011581 substrate binding site [chemical binding]; other site 205918011582 oxyanion hole (OAH) forming residues; other site 205918011583 trimer interface [polypeptide binding]; other site 205918011584 Helix-turn-helix domains; Region: HTH; cl00088 205918011585 transcriptional regulator SlyA; Provisional; Region: PRK03573 205918011586 outer membrane porin, OprD family; Region: OprD; pfam03573 205918011587 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 205918011588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918011589 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011590 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011591 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011592 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011593 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011594 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011595 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011596 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011597 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011598 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011599 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011600 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918011601 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 205918011602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918011603 NAD(P) binding site [chemical binding]; other site 205918011604 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 205918011605 active site 205918011606 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918011607 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 205918011608 NAD(P) binding site [chemical binding]; other site 205918011609 catalytic residues [active] 205918011610 Activator of aromatic catabolism; Region: XylR_N; pfam06505 205918011611 Heme NO binding; Region: HNOB; cl15268 205918011612 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 205918011613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918011614 Walker A motif; other site 205918011615 ATP binding site [chemical binding]; other site 205918011616 Walker B motif; other site 205918011617 arginine finger; other site 205918011618 Helix-turn-helix domains; Region: HTH; cl00088 205918011619 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 205918011620 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918011621 Helix-turn-helix domains; Region: HTH; cl00088 205918011622 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 205918011623 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 205918011624 conserved cys residue [active] 205918011625 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 205918011626 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 205918011627 conserved cys residue [active] 205918011628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918011629 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918011630 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 205918011631 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 205918011632 putative active site [active] 205918011633 metal binding site [ion binding]; metal-binding site 205918011634 LysE type translocator; Region: LysE; cl00565 205918011635 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011636 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011637 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011638 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918011640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 205918011641 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 205918011642 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 205918011643 dimer interface [polypeptide binding]; other site 205918011644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918011645 catalytic residue [active] 205918011646 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 205918011647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918011648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918011649 NAD(P) binding pocket [chemical binding]; other site 205918011650 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 205918011651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918011652 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 205918011653 ligand binding site [chemical binding]; other site 205918011654 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918011655 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 205918011656 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205918011657 active site 205918011658 nucleotide binding site [chemical binding]; other site 205918011659 HIGH motif; other site 205918011660 KMSKS motif; other site 205918011661 Cupin domain; Region: Cupin_2; cl09118 205918011662 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918011663 active site 205918011664 DNA binding site [nucleotide binding] 205918011665 Int/Topo IB signature motif; other site 205918011666 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 205918011667 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 205918011668 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 205918011669 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 205918011670 NADP binding site [chemical binding]; other site 205918011671 dimer interface [polypeptide binding]; other site 205918011672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918011673 Helix-turn-helix domains; Region: HTH; cl00088 205918011674 Nitronate monooxygenase; Region: NMO; pfam03060 205918011675 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 205918011676 FMN binding site [chemical binding]; other site 205918011677 substrate binding site [chemical binding]; other site 205918011678 putative catalytic residue [active] 205918011679 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 205918011680 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918011681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918011682 dimer interface [polypeptide binding]; other site 205918011683 conserved gate region; other site 205918011684 putative PBP binding loops; other site 205918011685 ABC-ATPase subunit interface; other site 205918011686 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011687 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011688 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011689 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011690 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011691 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 205918011692 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918011693 Walker A/P-loop; other site 205918011694 ATP binding site [chemical binding]; other site 205918011695 Q-loop/lid; other site 205918011696 ABC transporter signature motif; other site 205918011697 Walker B; other site 205918011698 D-loop; other site 205918011699 H-loop/switch region; other site 205918011700 TOBE domain; Region: TOBE_2; cl01440 205918011701 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 205918011702 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 205918011703 active site 205918011704 DNA binding site [nucleotide binding] 205918011705 Int/Topo IB signature motif; other site 205918011706 catalytic residues [active] 205918011707 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 205918011708 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 205918011709 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 205918011710 active site 205918011711 DNA binding site [nucleotide binding] 205918011712 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 205918011713 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918011714 Catalytic site [active] 205918011715 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 205918011716 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 205918011717 active site 205918011718 catalytic triad [active] 205918011719 oxyanion hole [active] 205918011720 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 205918011721 1 probable transmembrane helix predicted by TMHMM2.0 205918011722 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 205918011723 catalytic residue [active] 205918011724 Phage-related protein, tail component [Function unknown]; Region: COG4733 205918011725 Putative phage tail protein; Region: Phage-tail_3; pfam13550 205918011726 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 205918011727 Bacteriophage lambda tail assembly protein I; Region: Lambda_tail_I; cl01945 205918011728 1 probable transmembrane helix predicted by TMHMM2.0 205918011729 1 probable transmembrane helix predicted by TMHMM2.0 205918011730 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 205918011731 MPN+ (JAMM) motif; other site 205918011732 Zinc-binding site [ion binding]; other site 205918011733 NlpC/P60 family; Region: NLPC_P60; cl11438 205918011734 Phage minor tail protein L; Region: Phage_tail_L; cl01908 205918011735 Phage minor tail protein; Region: Phage_min_tail; cl01940 205918011736 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 205918011737 Phage-related minor tail protein [Function unknown]; Region: COG5281 205918011738 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 205918011739 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 205918011740 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 205918011741 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 205918011742 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 205918011743 Phage tail protein; Region: Phage_tail_3; pfam08813 205918011744 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 205918011745 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 205918011746 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 205918011747 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 205918011748 Phage terminase large subunit; Region: Terminase_3; cl12054 205918011749 Terminase-like family; Region: Terminase_6; pfam03237 205918011750 Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353 205918011751 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 205918011752 active site 205918011753 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011754 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011755 1 probable transmembrane helix predicted by TMHMM2.0 205918011756 seryl-tRNA synthetase; Provisional; Region: PRK05431 205918011757 1 probable transmembrane helix predicted by TMHMM2.0 205918011758 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011759 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011760 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 205918011761 NinB protein; Region: NinB; cl14671 205918011762 NAD-dependent deacetylase; Provisional; Region: PRK14138 205918011763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918011764 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 205918011765 non-specific DNA binding site [nucleotide binding]; other site 205918011766 salt bridge; other site 205918011767 sequence-specific DNA binding site [nucleotide binding]; other site 205918011768 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918011769 Catalytic site [active] 205918011770 1 probable transmembrane helix predicted by TMHMM2.0 205918011771 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 205918011772 RecT family; Region: RecT; cl04285 205918011773 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 205918011774 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 205918011775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918011776 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 205918011777 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 205918011778 Active Sites [active] 205918011779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918011780 DNA binding site [nucleotide binding] 205918011781 substrate interaction site [chemical binding]; other site 205918011782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918011783 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205918011784 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918011785 active site 205918011786 DNA binding site [nucleotide binding] 205918011787 Int/Topo IB signature motif; other site 205918011788 conserved hypothetical protein 205918011789 1 probable transmembrane helix predicted by TMHMM2.0 205918011790 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011791 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011792 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 205918011793 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 205918011794 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 205918011795 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 205918011796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918011797 DNA binding site [nucleotide binding] 205918011798 substrate interaction site [chemical binding]; other site 205918011799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918011800 phytoene desaturase; Region: crtI_fam; TIGR02734 205918011801 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 205918011802 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918011803 active site 205918011804 DNA binding site [nucleotide binding] 205918011805 Int/Topo IB signature motif; other site 205918011806 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918011807 hypothetical protein 205918011808 1 probable transmembrane helix predicted by TMHMM2.0 205918011809 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 205918011810 hypothetical protein 205918011811 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 205918011812 methionine synthase; Provisional; Region: PRK01207 205918011813 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 205918011814 substrate binding site [chemical binding]; other site 205918011815 THF binding site; other site 205918011816 zinc-binding site [ion binding]; other site 205918011817 Chitin binding domain; Region: Chitin_bind_3; cl03871 205918011818 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 205918011819 active site 205918011820 metal binding site [ion binding]; metal-binding site 205918011821 oxidase reductase; Provisional; Region: PTZ00273 205918011822 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 205918011823 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 205918011824 Isochorismatase family; Region: Isochorismatase; pfam00857 205918011825 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 205918011826 catalytic triad [active] 205918011827 conserved cis-peptide bond; other site 205918011828 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 205918011829 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 205918011830 Cytochrome c; Region: Cytochrom_C; cl11414 205918011831 Tannase and feruloyl esterase; Region: Tannase; pfam07519 205918011832 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 205918011833 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 205918011834 Protein export membrane protein; Region: SecD_SecF; cl14618 205918011835 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011836 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011837 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011838 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011839 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011840 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011841 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011842 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011843 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011844 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011845 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918011846 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 205918011847 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918011848 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918011849 1 probable transmembrane helix predicted by TMHMM2.0 205918011850 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 205918011851 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918011852 dimerization interface [polypeptide binding]; other site 205918011853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918011854 dimer interface [polypeptide binding]; other site 205918011855 phosphorylation site [posttranslational modification] 205918011856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918011857 ATP binding site [chemical binding]; other site 205918011858 Mg2+ binding site [ion binding]; other site 205918011859 G-X-G motif; other site 205918011860 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011861 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918011862 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 205918011863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918011864 active site 205918011865 phosphorylation site [posttranslational modification] 205918011866 intermolecular recognition site; other site 205918011867 dimerization interface [polypeptide binding]; other site 205918011868 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918011869 DNA binding site [nucleotide binding] 205918011870 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 205918011871 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 205918011872 active site 205918011873 non-prolyl cis peptide bond; other site 205918011874 acyl-CoA dehydrogenase 205918011875 Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, N-terminal 205918011876 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 205918011877 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 205918011878 Flavin binding site [chemical binding]; other site 205918011879 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918011880 TM-ABC transporter signature motif; other site 205918011881 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011882 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011883 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011884 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011885 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011886 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011887 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011888 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011889 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011890 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918011891 TM-ABC transporter signature motif; other site 205918011892 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011893 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011894 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011895 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011896 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011897 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011898 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011899 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011900 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918011901 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 205918011902 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 205918011903 Walker A/P-loop; other site 205918011904 ATP binding site [chemical binding]; other site 205918011905 Q-loop/lid; other site 205918011906 ABC transporter signature motif; other site 205918011907 Walker B; other site 205918011908 D-loop; other site 205918011909 H-loop/switch region; other site 205918011910 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 205918011911 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 205918011912 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 205918011913 putative ligand binding site [chemical binding]; other site 205918011914 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918011915 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918011916 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918011917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918011918 dimer interface [polypeptide binding]; other site 205918011919 putative CheW interface [polypeptide binding]; other site 205918011920 1 probable transmembrane helix predicted by TMHMM2.0 205918011921 VirK protein; Region: VirK; pfam06903 205918011922 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 205918011923 active site 205918011924 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 205918011925 putative dimerization interface [polypeptide binding]; other site 205918011926 putative ligand binding site [chemical binding]; other site 205918011927 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918011928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918011929 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 205918011930 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 205918011931 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 205918011932 putative ligand binding site [chemical binding]; other site 205918011933 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 205918011934 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 205918011935 Walker A/P-loop; other site 205918011936 ATP binding site [chemical binding]; other site 205918011937 Q-loop/lid; other site 205918011938 ABC transporter signature motif; other site 205918011939 Walker B; other site 205918011940 D-loop; other site 205918011941 H-loop/switch region; other site 205918011942 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 205918011943 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918011944 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918011945 TM-ABC transporter signature motif; other site 205918011946 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918011947 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918011948 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918011949 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918011950 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918011951 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918011952 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918011953 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918011954 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918011955 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918011956 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 205918011957 homotrimer interaction site [polypeptide binding]; other site 205918011958 putative active site [active] 205918011959 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 205918011960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918011961 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918011962 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918011963 substrate binding pocket [chemical binding]; other site 205918011964 membrane-bound complex binding site; other site 205918011965 hinge residues; other site 205918011966 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918011967 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 205918011968 Walker A/P-loop; other site 205918011969 ATP binding site [chemical binding]; other site 205918011970 Q-loop/lid; other site 205918011971 ABC transporter signature motif; other site 205918011972 Walker B; other site 205918011973 D-loop; other site 205918011974 H-loop/switch region; other site 205918011975 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918011976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918011977 dimer interface [polypeptide binding]; other site 205918011978 conserved gate region; other site 205918011979 putative PBP binding loops; other site 205918011980 ABC-ATPase subunit interface; other site 205918011981 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011982 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011983 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011984 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011985 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918011986 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 205918011987 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918011988 N-terminal plug; other site 205918011989 ligand-binding site [chemical binding]; other site 205918011990 1 probable transmembrane helix predicted by TMHMM2.0 205918011991 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 205918011992 Protein of unknown function, DUF393; Region: DUF393; cl01136 205918011993 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 205918011994 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011995 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011996 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011997 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918011998 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 205918011999 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 205918012000 GIY-YIG motif/motif A; other site 205918012001 active site 205918012002 catalytic site [active] 205918012003 putative DNA binding site [nucleotide binding]; other site 205918012004 metal binding site [ion binding]; metal-binding site 205918012005 UvrB/uvrC motif; Region: UVR; pfam02151 205918012006 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 205918012007 response regulator; Provisional; Region: PRK09483 205918012008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918012009 active site 205918012010 phosphorylation site [posttranslational modification] 205918012011 intermolecular recognition site; other site 205918012012 dimerization interface [polypeptide binding]; other site 205918012013 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918012014 DNA binding residues [nucleotide binding] 205918012015 dimerization interface [polypeptide binding]; other site 205918012016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918012017 non-specific DNA binding site [nucleotide binding]; other site 205918012018 salt bridge; other site 205918012019 sequence-specific DNA binding site [nucleotide binding]; other site 205918012020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 205918012021 NeuB family; Region: NeuB; cl00496 205918012022 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 205918012023 PPIC-type PPIASE domain; Region: Rotamase; cl08278 205918012024 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 205918012025 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 205918012026 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 205918012027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012028 dimer interface [polypeptide binding]; other site 205918012029 conserved gate region; other site 205918012030 putative PBP binding loops; other site 205918012031 ABC-ATPase subunit interface; other site 205918012032 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012033 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012034 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012035 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012036 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012037 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012038 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 205918012039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012040 dimer interface [polypeptide binding]; other site 205918012041 conserved gate region; other site 205918012042 putative PBP binding loops; other site 205918012043 ABC-ATPase subunit interface; other site 205918012044 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012045 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012046 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012047 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012048 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012049 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012050 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 205918012051 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918012052 Walker A/P-loop; other site 205918012053 ATP binding site [chemical binding]; other site 205918012054 Q-loop/lid; other site 205918012055 ABC transporter signature motif; other site 205918012056 Walker B; other site 205918012057 D-loop; other site 205918012058 H-loop/switch region; other site 205918012059 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918012060 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918012061 Walker A/P-loop; other site 205918012062 ATP binding site [chemical binding]; other site 205918012063 Q-loop/lid; other site 205918012064 ABC transporter signature motif; other site 205918012065 Walker B; other site 205918012066 D-loop; other site 205918012067 H-loop/switch region; other site 205918012068 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918012069 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 205918012070 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 205918012071 Walker A motif; other site 205918012072 ATP binding site [chemical binding]; other site 205918012073 Walker B motif; other site 205918012074 PPIC-type PPIASE domain; Region: Rotamase; cl08278 205918012075 phosphoglucomutase; Validated; Region: PRK07564 205918012076 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 205918012077 active site 205918012078 substrate binding site [chemical binding]; other site 205918012079 metal binding site [ion binding]; metal-binding site 205918012080 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 205918012081 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918012082 DEAD_2; Region: DEAD_2; pfam06733 205918012083 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918012084 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 205918012085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918012086 DNA-binding site [nucleotide binding]; DNA binding site 205918012087 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205918012088 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918012089 catalytic residue [active] 205918012090 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 205918012091 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 205918012092 putative NAD(P) binding site [chemical binding]; other site 205918012093 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918012094 Helix-turn-helix domains; Region: HTH; cl00088 205918012095 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 205918012096 putative substrate binding pocket [chemical binding]; other site 205918012097 putative dimerization interface [polypeptide binding]; other site 205918012098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918012099 ATP binding site [chemical binding]; other site 205918012100 putative Mg++ binding site [ion binding]; other site 205918012101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918012102 nucleotide binding region [chemical binding]; other site 205918012103 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 205918012104 ATP-binding site [chemical binding]; other site 205918012105 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 205918012106 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918012107 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 205918012108 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 205918012109 Family description; Region: UvrD_C_2; cl15862 205918012110 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 205918012111 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 205918012112 conserved cys residue [active] 205918012113 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918012114 1 probable transmembrane helix predicted by TMHMM2.0 205918012115 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 205918012116 NMT1-like family; Region: NMT1_2; cl15260 205918012117 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 205918012118 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 205918012119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918012120 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 205918012121 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 205918012122 active site 205918012123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918012124 DNA-binding site [nucleotide binding]; DNA binding site 205918012125 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 205918012126 UTRA domain; Region: UTRA; cl01230 205918012127 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 205918012128 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 205918012129 Na binding site [ion binding]; other site 205918012130 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012131 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012132 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012133 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012134 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012135 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012136 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012137 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012138 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012139 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012140 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012141 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012142 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 205918012143 substrate binding site [chemical binding]; other site 205918012144 ATP binding site [chemical binding]; other site 205918012145 HipA N-terminal domain; Region: Couple_hipA; cl11853 205918012146 HipA-like N-terminal domain; Region: HipA_N; pfam07805 205918012147 HipA-like C-terminal domain; Region: HipA_C; pfam07804 205918012148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918012149 non-specific DNA binding site [nucleotide binding]; other site 205918012150 salt bridge; other site 205918012151 sequence-specific DNA binding site [nucleotide binding]; other site 205918012152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918012153 putative substrate translocation pore; other site 205918012154 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012155 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012156 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012157 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012158 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012159 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012160 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012161 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012162 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012163 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012164 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012165 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918012167 Helix-turn-helix domains; Region: HTH; cl00088 205918012168 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205918012169 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205918012170 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918012171 Walker A/P-loop; other site 205918012172 ATP binding site [chemical binding]; other site 205918012173 Q-loop/lid; other site 205918012174 ABC transporter signature motif; other site 205918012175 Walker B; other site 205918012176 D-loop; other site 205918012177 H-loop/switch region; other site 205918012178 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012179 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012180 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012181 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012182 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918012184 Helix-turn-helix domains; Region: HTH; cl00088 205918012185 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 205918012186 putative dimerization interface [polypeptide binding]; other site 205918012187 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 205918012188 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 205918012189 putative metal binding site [ion binding]; other site 205918012190 High-affinity nickel-transport protein; Region: NicO; cl00964 205918012191 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012192 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012193 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012194 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012195 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012196 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012197 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 205918012198 putative homodimer interface [polypeptide binding]; other site 205918012199 putative homotetramer interface [polypeptide binding]; other site 205918012200 putative metal binding site [ion binding]; other site 205918012201 putative homodimer-homodimer interface [polypeptide binding]; other site 205918012202 putative allosteric switch controlling residues; other site 205918012203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918012204 Helix-turn-helix domains; Region: HTH; cl00088 205918012205 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 205918012206 FMN binding site [chemical binding]; other site 205918012207 active site 205918012208 substrate binding site [chemical binding]; other site 205918012209 catalytic residue [active] 205918012210 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 205918012211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918012212 NAD(P) binding site [chemical binding]; other site 205918012213 active site 205918012214 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 205918012215 active site 205918012216 FMN binding site [chemical binding]; other site 205918012217 substrate binding site [chemical binding]; other site 205918012218 putative catalytic residue [active] 205918012219 D-serine deaminase transcriptional activator; Region: dsdC; TIGR02036 205918012220 Helix-turn-helix domains; Region: HTH; cl00088 205918012221 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918012222 putative effector binding pocket; other site 205918012223 dimerization interface [polypeptide binding]; other site 205918012224 Response regulator receiver domain; Region: Response_reg; pfam00072 205918012225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918012226 active site 205918012227 phosphorylation site [posttranslational modification] 205918012228 intermolecular recognition site; other site 205918012229 dimerization interface [polypeptide binding]; other site 205918012230 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918012231 metal binding site [ion binding]; metal-binding site 205918012232 active site 205918012233 I-site; other site 205918012234 CHASE domain; Region: CHASE; cl01369 205918012235 PAS domain S-box; Region: sensory_box; TIGR00229 205918012236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918012237 putative active site [active] 205918012238 heme pocket [chemical binding]; other site 205918012239 PAS domain; Region: PAS_9; pfam13426 205918012240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918012241 putative active site [active] 205918012242 heme pocket [chemical binding]; other site 205918012243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918012244 dimer interface [polypeptide binding]; other site 205918012245 phosphorylation site [posttranslational modification] 205918012246 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 205918012247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918012248 ATP binding site [chemical binding]; other site 205918012249 Mg2+ binding site [ion binding]; other site 205918012250 G-X-G motif; other site 205918012251 Response regulator receiver domain; Region: Response_reg; pfam00072 205918012252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 205918012253 active site 205918012254 phosphorylation site [posttranslational modification] 205918012255 dimerization interface [polypeptide binding]; other site 205918012256 Response regulator receiver domain; Region: Response_reg; pfam00072 205918012257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918012258 active site 205918012259 phosphorylation site [posttranslational modification] 205918012260 intermolecular recognition site; other site 205918012261 dimerization interface [polypeptide binding]; other site 205918012262 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 205918012263 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012264 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012265 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 205918012266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918012267 substrate binding pocket [chemical binding]; other site 205918012268 membrane-bound complex binding site; other site 205918012269 hinge residues; other site 205918012270 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918012271 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 205918012272 Walker A/P-loop; other site 205918012273 ATP binding site [chemical binding]; other site 205918012274 Q-loop/lid; other site 205918012275 ABC transporter signature motif; other site 205918012276 Walker B; other site 205918012277 D-loop; other site 205918012278 H-loop/switch region; other site 205918012279 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918012280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012281 dimer interface [polypeptide binding]; other site 205918012282 conserved gate region; other site 205918012283 putative PBP binding loops; other site 205918012284 ABC-ATPase subunit interface; other site 205918012285 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012286 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012287 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012289 dimer interface [polypeptide binding]; other site 205918012290 conserved gate region; other site 205918012291 putative PBP binding loops; other site 205918012292 ABC-ATPase subunit interface; other site 205918012293 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012294 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012295 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012296 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012297 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918012299 Helix-turn-helix domains; Region: HTH; cl00088 205918012300 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 205918012301 putative effector binding pocket; other site 205918012302 putative dimerization interface [polypeptide binding]; other site 205918012303 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 205918012304 active site 1 [active] 205918012305 dimer interface [polypeptide binding]; other site 205918012306 hexamer interface [polypeptide binding]; other site 205918012307 active site 2 [active] 205918012308 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 205918012309 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 205918012310 dimer interface [polypeptide binding]; other site 205918012311 FMN binding site [chemical binding]; other site 205918012312 Uncharacterized conserved protein [Function unknown]; Region: COG2128 205918012313 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918012314 transcriptional regulator; Provisional; Region: PRK10632 205918012315 Helix-turn-helix domains; Region: HTH; cl00088 205918012316 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918012317 putative effector binding pocket; other site 205918012318 dimerization interface [polypeptide binding]; other site 205918012319 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 205918012320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918012321 1 probable transmembrane helix predicted by TMHMM2.0 205918012322 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 205918012323 putative active site [active] 205918012324 metal binding site [ion binding]; metal-binding site 205918012325 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918012326 DoxX; Region: DoxX; cl00976 205918012327 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012328 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012329 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012330 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012331 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 205918012332 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 205918012333 substrate binding site [chemical binding]; other site 205918012334 catalytic Zn binding site [ion binding]; other site 205918012335 NAD binding site [chemical binding]; other site 205918012336 structural Zn binding site [ion binding]; other site 205918012337 dimer interface [polypeptide binding]; other site 205918012338 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 205918012339 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 205918012340 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205918012341 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205918012342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012343 dimer interface [polypeptide binding]; other site 205918012344 conserved gate region; other site 205918012345 putative PBP binding loops; other site 205918012346 ABC-ATPase subunit interface; other site 205918012347 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012348 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012349 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012350 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012351 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012352 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012354 dimer interface [polypeptide binding]; other site 205918012355 conserved gate region; other site 205918012356 putative PBP binding loops; other site 205918012357 ABC-ATPase subunit interface; other site 205918012358 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012359 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012360 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012361 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012362 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012363 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012364 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 205918012365 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918012366 Walker A/P-loop; other site 205918012367 ATP binding site [chemical binding]; other site 205918012368 Q-loop/lid; other site 205918012369 ABC transporter signature motif; other site 205918012370 Walker B; other site 205918012371 D-loop; other site 205918012372 H-loop/switch region; other site 205918012373 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918012374 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918012375 Walker A/P-loop; other site 205918012376 ATP binding site [chemical binding]; other site 205918012377 Q-loop/lid; other site 205918012378 ABC transporter signature motif; other site 205918012379 Walker B; other site 205918012380 D-loop; other site 205918012381 H-loop/switch region; other site 205918012382 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918012383 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 205918012384 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918012385 substrate binding pocket [chemical binding]; other site 205918012386 membrane-bound complex binding site; other site 205918012387 hinge residues; other site 205918012388 1 probable transmembrane helix predicted by TMHMM2.0 205918012389 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918012390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012391 dimer interface [polypeptide binding]; other site 205918012392 conserved gate region; other site 205918012393 putative PBP binding loops; other site 205918012394 ABC-ATPase subunit interface; other site 205918012395 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012396 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012397 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012399 dimer interface [polypeptide binding]; other site 205918012400 conserved gate region; other site 205918012401 putative PBP binding loops; other site 205918012402 ABC-ATPase subunit interface; other site 205918012403 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012404 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012405 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012406 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918012407 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 205918012408 Walker A/P-loop; other site 205918012409 ATP binding site [chemical binding]; other site 205918012410 Q-loop/lid; other site 205918012411 ABC transporter signature motif; other site 205918012412 Walker B; other site 205918012413 D-loop; other site 205918012414 H-loop/switch region; other site 205918012415 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 205918012416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918012417 dimerization interface [polypeptide binding]; other site 205918012418 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918012419 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918012420 dimer interface [polypeptide binding]; other site 205918012421 putative CheW interface [polypeptide binding]; other site 205918012422 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012423 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012424 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918012425 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918012426 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918012427 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 205918012428 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012429 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012430 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012431 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012432 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012433 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012434 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012435 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012436 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012437 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012438 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012439 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012440 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918012441 HEAT repeats; Region: HEAT_2; pfam13646 205918012442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918012443 binding surface 205918012444 TPR motif; other site 205918012445 TPR repeat; Region: TPR_11; pfam13414 205918012446 1 probable transmembrane helix predicted by TMHMM2.0 205918012447 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 205918012448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 205918012449 dimer interface [polypeptide binding]; other site 205918012450 active site 205918012451 metal binding site [ion binding]; metal-binding site 205918012452 glutathione binding site [chemical binding]; other site 205918012453 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 205918012454 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 205918012455 catalytic residue [active] 205918012456 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 205918012457 catalytic residues [active] 205918012458 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918012459 peroxiredoxin; Region: AhpC; TIGR03137 205918012460 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 205918012461 dimer interface [polypeptide binding]; other site 205918012462 decamer (pentamer of dimers) interface [polypeptide binding]; other site 205918012463 catalytic triad [active] 205918012464 peroxidatic and resolving cysteines [active] 205918012465 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 205918012466 DNA binding site [nucleotide binding] 205918012467 dimer interface [polypeptide binding]; other site 205918012468 active site 205918012469 Int/Topo IB signature motif; other site 205918012470 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 205918012471 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205918012472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918012473 PAS domain; Region: PAS_9; pfam13426 205918012474 putative active site [active] 205918012475 heme pocket [chemical binding]; other site 205918012476 histidine kinase; Provisional; Region: PRK13557 205918012477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918012478 ATP binding site [chemical binding]; other site 205918012479 Mg2+ binding site [ion binding]; other site 205918012480 G-X-G motif; other site 205918012481 glutathione reductase; Validated; Region: PRK06116 205918012482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918012483 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205918012484 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 205918012485 active site 205918012486 tetramer interface; other site 205918012487 1 probable transmembrane helix predicted by TMHMM2.0 205918012488 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 205918012489 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 205918012490 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 205918012491 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 205918012492 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 205918012493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918012494 active site 205918012495 motif I; other site 205918012496 motif II; other site 205918012497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918012498 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 205918012499 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 205918012500 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 205918012501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918012502 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 205918012503 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 205918012504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918012505 Coenzyme A binding pocket [chemical binding]; other site 205918012506 glycogen synthase; Provisional; Region: glgA; PRK00654 205918012507 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 205918012508 ADP-binding pocket [chemical binding]; other site 205918012509 homodimer interface [polypeptide binding]; other site 205918012510 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 205918012511 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 205918012512 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 205918012513 catalytic site [active] 205918012514 active site 205918012515 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 205918012516 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 205918012517 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 205918012518 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 205918012519 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 205918012520 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 205918012521 active site 205918012522 catalytic site [active] 205918012523 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 205918012524 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 205918012525 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 205918012526 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 205918012527 active site 205918012528 catalytic site [active] 205918012529 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918012530 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 205918012531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918012532 S-adenosylmethionine binding site [chemical binding]; other site 205918012533 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205918012534 active site 205918012535 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 205918012536 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 205918012537 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 205918012538 LysR family transcriptional regulator; Provisional; Region: PRK14997 205918012539 Helix-turn-helix domains; Region: HTH; cl00088 205918012540 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 205918012541 putative effector binding pocket; other site 205918012542 putative dimerization interface [polypeptide binding]; other site 205918012543 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 205918012544 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918012545 Protein of unknown function (DUF419); Region: DUF419; cl15265 205918012546 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 205918012547 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012548 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012549 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918012550 Bacitracin resistance protein BacA; Region: BacA; cl00858 205918012551 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012552 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012553 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012554 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012555 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012556 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012557 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 205918012558 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012559 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012560 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012561 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012562 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918012563 AAA domain; Region: AAA_28; pfam13521 205918012564 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918012565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918012566 Walker A motif; other site 205918012567 ATP binding site [chemical binding]; other site 205918012568 Walker B motif; other site 205918012569 arginine finger; other site 205918012570 Helix-turn-helix domains; Region: HTH; cl00088 205918012571 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 205918012572 metal ion-dependent adhesion site (MIDAS); other site 205918012573 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 205918012574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918012575 Walker A motif; other site 205918012576 ATP binding site [chemical binding]; other site 205918012577 Walker B motif; other site 205918012578 arginine finger; other site 205918012579 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 205918012580 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 205918012581 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 205918012582 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 205918012583 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918012584 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 205918012585 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 205918012586 1 probable transmembrane helix predicted by TMHMM2.0 205918012587 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 205918012588 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012589 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012590 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012591 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012592 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012593 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012594 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 205918012595 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 205918012596 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 205918012597 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 205918012598 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 205918012599 dimer interface [polypeptide binding]; other site 205918012600 PYR/PP interface [polypeptide binding]; other site 205918012601 TPP binding site [chemical binding]; other site 205918012602 substrate binding site [chemical binding]; other site 205918012603 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 205918012604 TPP-binding site; other site 205918012605 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 205918012606 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918012607 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918012608 putative DNA binding site [nucleotide binding]; other site 205918012609 putative Zn2+ binding site [ion binding]; other site 205918012610 AsnC family; Region: AsnC_trans_reg; pfam01037 205918012611 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 205918012612 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 205918012613 1 probable transmembrane helix predicted by TMHMM2.0 205918012614 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 205918012615 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 205918012616 active site 205918012617 Zn binding site [ion binding]; other site 205918012618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 205918012619 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012620 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012621 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012622 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012623 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012624 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012625 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012626 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012627 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012628 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012629 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012630 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012631 Helix-turn-helix domains; Region: HTH; cl00088 205918012632 Leucine rich repeat; Region: LRR_8; pfam13855 205918012633 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 205918012634 Leucine rich repeat; Region: LRR_8; pfam13855 205918012635 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 205918012636 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918012637 active site 205918012638 ATP binding site [chemical binding]; other site 205918012639 substrate binding site [chemical binding]; other site 205918012640 activation loop (A-loop); other site 205918012641 Transcriptional regulator; Region: Transcrip_reg; cl00361 205918012642 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 205918012643 enoyl-CoA hydratase; Provisional; Region: PRK05862 205918012644 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918012645 substrate binding site [chemical binding]; other site 205918012646 oxyanion hole (OAH) forming residues; other site 205918012647 trimer interface [polypeptide binding]; other site 205918012648 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 205918012649 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 205918012650 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 205918012651 dimer interface [polypeptide binding]; other site 205918012652 active site 205918012653 Late embryogenesis abundant protein; Region: LEA_2; cl12118 205918012654 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 205918012655 1 probable transmembrane helix predicted by TMHMM2.0 205918012656 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 205918012657 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 205918012658 PA14 domain; Region: PA14; cl08459 205918012659 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 205918012660 Fibronectin type III-like domain; Region: Fn3-like; cl15273 205918012661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918012662 Helix-turn-helix domains; Region: HTH; cl00088 205918012663 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 205918012664 MatE; Region: MatE; cl10513 205918012665 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012666 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012667 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012668 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012669 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012670 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012671 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012672 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012673 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012674 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012675 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012676 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918012677 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 205918012678 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 205918012679 active site 205918012680 Zn binding site [ion binding]; other site 205918012681 Paraquat-inducible protein A; Region: PqiA; pfam04403 205918012682 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012683 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012684 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012685 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012686 primosome assembly protein PriA; Validated; Region: PRK05580 205918012687 Paraquat-inducible protein A; Region: PqiA; pfam04403 205918012688 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012689 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012690 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012691 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012692 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 205918012693 mce related protein; Region: MCE; pfam02470 205918012694 mce related protein; Region: MCE; pfam02470 205918012695 mce related protein; Region: MCE; pfam02470 205918012696 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 205918012697 1 probable transmembrane helix predicted by TMHMM2.0 205918012698 Protein of unknown function (DUF330); Region: DUF330; cl01135 205918012699 LysR family transcriptional regulator; Provisional; Region: PRK14997 205918012700 Helix-turn-helix domains; Region: HTH; cl00088 205918012701 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918012702 putative effector binding pocket; other site 205918012703 dimerization interface [polypeptide binding]; other site 205918012704 Cupin domain; Region: Cupin_2; cl09118 205918012705 Pirin-related protein [General function prediction only]; Region: COG1741 205918012706 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918012707 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205918012708 active site 205918012709 catalytic tetrad [active] 205918012710 Helix-turn-helix domains; Region: HTH; cl00088 205918012711 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 205918012712 putative effector binding pocket; other site 205918012713 putative dimerization interface [polypeptide binding]; other site 205918012714 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 205918012715 Na binding site [ion binding]; other site 205918012716 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918012717 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918012718 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918012719 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918012720 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918012721 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918012722 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918012723 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918012724 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918012725 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918012726 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918012727 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918012728 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918012729 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012730 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012731 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 205918012732 Phosphotransferase enzyme family; Region: APH; pfam01636 205918012733 active site 205918012734 ATP binding site [chemical binding]; other site 205918012735 substrate binding site [chemical binding]; other site 205918012736 dimer interface [polypeptide binding]; other site 205918012737 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 205918012738 active site 205918012739 ATP binding site [chemical binding]; other site 205918012740 dimer interface [polypeptide binding]; other site 205918012741 substrate binding site [chemical binding]; other site 205918012742 allantoate amidohydrolase; Reviewed; Region: PRK09290 205918012743 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 205918012744 active site 205918012745 metal binding site [ion binding]; metal-binding site 205918012746 dimer interface [polypeptide binding]; other site 205918012747 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 205918012748 Helix-turn-helix domains; Region: HTH; cl00088 205918012749 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 205918012750 putative amidase; Provisional; Region: PRK06169 205918012751 Amidase; Region: Amidase; cl11426 205918012752 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 205918012753 active site 205918012754 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918012755 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918012756 GAF domain; Region: GAF; cl15785 205918012757 histidine kinase; Provisional; Region: PRK13557 205918012758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918012759 ATP binding site [chemical binding]; other site 205918012760 Mg2+ binding site [ion binding]; other site 205918012761 G-X-G motif; other site 205918012762 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918012763 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 205918012764 C-terminal domain interface [polypeptide binding]; other site 205918012765 GSH binding site (G-site) [chemical binding]; other site 205918012766 dimer interface [polypeptide binding]; other site 205918012767 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 205918012768 dimer interface [polypeptide binding]; other site 205918012769 N-terminal domain interface [polypeptide binding]; other site 205918012770 substrate binding pocket (H-site) [chemical binding]; other site 205918012771 transcriptional regulator; Provisional; Region: PRK10632 205918012772 Helix-turn-helix domains; Region: HTH; cl00088 205918012773 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 205918012774 putative effector binding pocket; other site 205918012775 putative dimerization interface [polypeptide binding]; other site 205918012776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918012777 putative substrate translocation pore; other site 205918012778 Fungal trichothecene efflux pump (TRI12); Region: TRI12; pfam06609 205918012779 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012780 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012781 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012782 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012783 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012784 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012785 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012786 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012787 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012788 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012789 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012790 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012791 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012792 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918012793 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 205918012794 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 205918012795 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 205918012796 active site 205918012797 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 205918012798 dimer interface [polypeptide binding]; other site 205918012799 non-prolyl cis peptide bond; other site 205918012800 insertion regions; other site 205918012801 Nitronate monooxygenase; Region: NMO; pfam03060 205918012802 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 205918012803 FMN binding site [chemical binding]; other site 205918012804 substrate binding site [chemical binding]; other site 205918012805 putative catalytic residue [active] 205918012806 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 205918012807 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 205918012808 tartrate dehydrogenase; Provisional; Region: PRK08194 205918012809 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 205918012810 active site 205918012811 catalytic residues [active] 205918012812 metal binding site [ion binding]; metal-binding site 205918012813 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918012814 Helix-turn-helix domains; Region: HTH; cl00088 205918012815 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918012816 dimerization interface [polypeptide binding]; other site 205918012817 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918012818 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 205918012819 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 205918012820 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 205918012821 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918012822 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 205918012823 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 205918012824 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918012825 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918012826 1 probable transmembrane helix predicted by TMHMM2.0 205918012827 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine'...; Region: Peptidase_C39_likeA; cd02417 205918012828 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 205918012829 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205918012830 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918012831 Walker A/P-loop; other site 205918012832 ATP binding site [chemical binding]; other site 205918012833 Q-loop/lid; other site 205918012834 ABC transporter signature motif; other site 205918012835 Walker B; other site 205918012836 D-loop; other site 205918012837 H-loop/switch region; other site 205918012838 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012839 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012840 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012841 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012842 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 205918012843 1 probable transmembrane helix predicted by TMHMM2.0 205918012844 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 205918012845 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 205918012846 metal binding site [ion binding]; metal-binding site 205918012847 dimer interface [polypeptide binding]; other site 205918012848 acriflavin resistance protein 205918012849 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012850 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012851 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012852 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918012853 acriflavin resistance protein 205918012854 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918012855 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918012856 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918012857 MltA-interacting protein MipA; Region: MipA; cl01504 205918012858 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 205918012859 1 probable transmembrane helix predicted by TMHMM2.0 205918012860 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918012861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918012862 active site 205918012863 phosphorylation site [posttranslational modification] 205918012864 intermolecular recognition site; other site 205918012865 dimerization interface [polypeptide binding]; other site 205918012866 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918012867 DNA binding site [nucleotide binding] 205918012868 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918012869 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918012870 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918012871 dimer interface [polypeptide binding]; other site 205918012872 phosphorylation site [posttranslational modification] 205918012873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918012874 ATP binding site [chemical binding]; other site 205918012875 Mg2+ binding site [ion binding]; other site 205918012876 G-X-G motif; other site 205918012877 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012878 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918012879 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 205918012880 Sulfate transporter family; Region: Sulfate_transp; cl15842 205918012881 Sulfate transporter family; Region: Sulfate_transp; cl15842 205918012882 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 205918012883 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012884 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012885 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012886 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012887 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012888 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012889 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012890 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012891 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012892 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012893 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918012894 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 205918012895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918012896 DNA-binding site [nucleotide binding]; DNA binding site 205918012897 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918012898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918012899 homodimer interface [polypeptide binding]; other site 205918012900 catalytic residue [active] 205918012901 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918012902 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 205918012903 putative ADP-binding pocket [chemical binding]; other site 205918012904 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 205918012905 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 205918012906 1 probable transmembrane helix predicted by TMHMM2.0 205918012907 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918012908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918012909 active site 205918012910 phosphorylation site [posttranslational modification] 205918012911 intermolecular recognition site; other site 205918012912 dimerization interface [polypeptide binding]; other site 205918012913 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918012914 DNA binding site [nucleotide binding] 205918012915 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 205918012916 active site 205918012917 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012918 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012919 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012920 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012921 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012922 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012923 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 205918012924 catalytic core [active] 205918012925 1 probable transmembrane helix predicted by TMHMM2.0 205918012926 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 205918012927 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 205918012928 putative ligand binding residues [chemical binding]; other site 205918012929 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 205918012930 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918012931 ABC-ATPase subunit interface; other site 205918012932 dimer interface [polypeptide binding]; other site 205918012933 putative PBP binding regions; other site 205918012934 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012935 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012936 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012937 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012938 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012939 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012940 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012941 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012942 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918012943 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 205918012944 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 205918012945 Walker A/P-loop; other site 205918012946 ATP binding site [chemical binding]; other site 205918012947 Q-loop/lid; other site 205918012948 ABC transporter signature motif; other site 205918012949 Walker B; other site 205918012950 D-loop; other site 205918012951 H-loop/switch region; other site 205918012952 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 205918012953 Peptidase family U32; Region: Peptidase_U32; cl03113 205918012954 Collagenase; Region: DUF3656; pfam12392 205918012955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918012956 Coenzyme A binding pocket [chemical binding]; other site 205918012957 nitrite reductase subunit NirD; Provisional; Region: PRK14989 205918012958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918012959 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 205918012960 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 205918012961 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 205918012962 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918012963 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918012964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918012965 Helix-turn-helix domains; Region: HTH; cl00088 205918012966 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 205918012967 putative substrate binding pocket [chemical binding]; other site 205918012968 putative dimerization interface [polypeptide binding]; other site 205918012969 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 205918012970 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 205918012971 Walker A/P-loop; other site 205918012972 ATP binding site [chemical binding]; other site 205918012973 Q-loop/lid; other site 205918012974 ABC transporter signature motif; other site 205918012975 Walker B; other site 205918012976 D-loop; other site 205918012977 H-loop/switch region; other site 205918012978 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 205918012979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012980 dimer interface [polypeptide binding]; other site 205918012981 conserved gate region; other site 205918012982 putative PBP binding loops; other site 205918012983 ABC-ATPase subunit interface; other site 205918012984 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012985 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012986 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012987 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012988 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012989 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918012990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918012991 dimer interface [polypeptide binding]; other site 205918012992 conserved gate region; other site 205918012993 putative PBP binding loops; other site 205918012994 ABC-ATPase subunit interface; other site 205918012995 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012996 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012997 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012998 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918012999 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013000 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918013001 MarB protein; Region: MarB; cl08087 205918013002 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 205918013003 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl16918 205918013004 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918013005 Helix-turn-helix domains; Region: HTH; cl00088 205918013006 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 205918013007 putative dimerization interface [polypeptide binding]; other site 205918013008 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 205918013009 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 205918013010 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 205918013011 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013012 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013013 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013014 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013015 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013016 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013017 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013018 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013019 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013020 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013021 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 205918013022 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 205918013023 dimerization interface [polypeptide binding]; other site 205918013024 putative active cleft [active] 205918013025 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918013026 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918013027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918013028 dimerization interface [polypeptide binding]; other site 205918013029 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918013030 dimer interface [polypeptide binding]; other site 205918013031 putative CheW interface [polypeptide binding]; other site 205918013032 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013033 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013034 Glycerate kinase family; Region: Gly_kinase; cl00841 205918013035 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 205918013036 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 205918013037 Helix-turn-helix domains; Region: HTH; cl00088 205918013038 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 205918013039 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918013040 Transcriptional regulators [Transcription]; Region: FadR; COG2186 205918013041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918013042 DNA-binding site [nucleotide binding]; DNA binding site 205918013043 FCD domain; Region: FCD; cl11656 205918013044 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 205918013045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918013046 putative substrate translocation pore; other site 205918013047 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013048 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013049 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013050 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013051 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013052 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013053 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013054 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013055 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013056 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013057 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013058 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013059 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 205918013060 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 205918013061 active site 205918013062 tetramer interface [polypeptide binding]; other site 205918013063 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 205918013064 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013065 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013066 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013067 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013068 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013069 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 205918013070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918013071 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918013072 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918013073 N-terminal plug; other site 205918013074 ligand-binding site [chemical binding]; other site 205918013075 Isochorismatase family; Region: Isochorismatase; pfam00857 205918013076 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 205918013077 catalytic triad [active] 205918013078 metal binding site [ion binding]; metal-binding site 205918013079 conserved cis-peptide bond; other site 205918013080 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 205918013081 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013082 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013083 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013084 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013085 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013086 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918013088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918013089 active site 205918013090 phosphorylation site [posttranslational modification] 205918013091 intermolecular recognition site; other site 205918013092 dimerization interface [polypeptide binding]; other site 205918013093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918013094 DNA binding site [nucleotide binding] 205918013095 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 205918013096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918013097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918013098 dimer interface [polypeptide binding]; other site 205918013099 phosphorylation site [posttranslational modification] 205918013100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918013101 ATP binding site [chemical binding]; other site 205918013102 Mg2+ binding site [ion binding]; other site 205918013103 G-X-G motif; other site 205918013104 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013105 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013106 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918013107 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918013108 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918013109 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918013110 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 205918013111 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918013112 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918013113 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 205918013114 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013115 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013116 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013117 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013118 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013119 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013120 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013121 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013122 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013123 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013124 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918013125 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 205918013126 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 205918013127 active site 205918013128 benzoate transport; Region: 2A0115; TIGR00895 205918013129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918013130 putative substrate translocation pore; other site 205918013131 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013132 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013133 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013134 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013135 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013136 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013137 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013138 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013139 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013140 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013141 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013142 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013143 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 205918013144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918013145 DNA-binding site [nucleotide binding]; DNA binding site 205918013146 UTRA domain; Region: UTRA; cl01230 205918013147 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 205918013148 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 205918013149 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918013150 ABC transporter signature motif; other site 205918013151 Walker B; other site 205918013152 D-loop; other site 205918013153 H-loop/switch region; other site 205918013154 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 205918013155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918013156 putative substrate translocation pore; other site 205918013157 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013158 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013159 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013160 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013161 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013162 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013163 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013164 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013165 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013166 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013167 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013168 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013169 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013170 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013171 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013172 Predicted esterase [General function prediction only]; Region: COG0400 205918013173 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918013174 type II secretion system protein D; Region: type_II_gspD; TIGR02517 205918013175 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918013176 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918013177 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918013178 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 205918013179 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 205918013180 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 205918013181 1 probable transmembrane helix predicted by TMHMM2.0 205918013182 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 205918013183 1 probable transmembrane helix predicted by TMHMM2.0 205918013184 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 205918013185 1 probable transmembrane helix predicted by TMHMM2.0 205918013186 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 205918013187 1 probable transmembrane helix predicted by TMHMM2.0 205918013188 general secretion pathway protein J; Validated; Region: PRK08808 205918013189 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 205918013190 1 probable transmembrane helix predicted by TMHMM2.0 205918013191 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 205918013192 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 205918013193 1 probable transmembrane helix predicted by TMHMM2.0 205918013194 1 probable transmembrane helix predicted by TMHMM2.0 205918013195 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 205918013196 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 205918013197 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 205918013198 1 probable transmembrane helix predicted by TMHMM2.0 205918013199 type II secretion system protein F; Region: GspF; TIGR02120 205918013200 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 205918013201 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 205918013202 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013203 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013204 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013205 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 205918013206 type II secretion system protein E; Region: type_II_gspE; TIGR02533 205918013207 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 205918013208 Walker A motif; other site 205918013209 ATP binding site [chemical binding]; other site 205918013210 Walker B motif; other site 205918013211 1 probable transmembrane helix predicted by TMHMM2.0 205918013212 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 205918013213 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 205918013214 PA14 domain; Region: PA14; cl08459 205918013215 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 205918013216 Fibronectin type III-like domain; Region: Fn3-like; cl15273 205918013217 Helix-turn-helix domains; Region: HTH; cl00088 205918013218 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 205918013219 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 205918013220 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918013221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918013222 Helix-turn-helix domains; Region: HTH; cl00088 205918013223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918013224 dimerization interface [polypeptide binding]; other site 205918013225 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918013226 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 205918013227 dimer interface [polypeptide binding]; other site 205918013228 NADP binding site [chemical binding]; other site 205918013229 catalytic residues [active] 205918013230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918013231 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 205918013232 1 probable transmembrane helix predicted by TMHMM2.0 205918013233 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 205918013234 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 205918013235 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918013236 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918013237 1 probable transmembrane helix predicted by TMHMM2.0 205918013238 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 205918013239 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 205918013240 Walker A/P-loop; other site 205918013241 ATP binding site [chemical binding]; other site 205918013242 Q-loop/lid; other site 205918013243 ABC transporter signature motif; other site 205918013244 Walker B; other site 205918013245 D-loop; other site 205918013246 H-loop/switch region; other site 205918013247 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013248 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013249 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013250 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013251 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013252 Protease inhibitor Inh; Region: Inh; pfam02974 205918013253 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 205918013254 active site 205918013255 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918013256 YccA-like proteins; Region: YccA_like; cd10433 205918013257 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013258 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013259 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013260 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013261 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013262 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013263 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013264 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918013265 Helix-turn-helix domains; Region: HTH; cl00088 205918013266 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 205918013267 putative dimerization interface [polypeptide binding]; other site 205918013268 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 205918013269 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918013270 citrate-proton symporter; Provisional; Region: PRK15075 205918013271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918013272 putative substrate translocation pore; other site 205918013273 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013274 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013275 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013276 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013277 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013278 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013279 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013280 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013281 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013282 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013283 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013284 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013285 DsrE/DsrF-like family; Region: DrsE; cl00672 205918013286 DsrE/DsrF-like family; Region: DrsE; cl00672 205918013287 DsrE/DsrF-like family; Region: DrsE; cl00672 205918013288 DsrC like protein; Region: DsrC; cl01101 205918013289 hypothetical protein; Validated; Region: PRK09071 205918013290 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 205918013291 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 205918013292 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 205918013293 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 205918013294 putative dimer interface [polypeptide binding]; other site 205918013295 N-terminal domain interface [polypeptide binding]; other site 205918013296 putative substrate binding pocket (H-site) [chemical binding]; other site 205918013297 siroheme synthase; Provisional; Region: cysG; PRK10637 205918013298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918013299 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 205918013300 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 205918013301 seryl-tRNA synthetase; Region: serS; TIGR00414 205918013302 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 205918013303 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 205918013304 CrcB-like protein; Region: CRCB; cl09114 205918013305 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013306 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013307 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013308 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013309 recombination factor protein RarA; Reviewed; Region: PRK13342 205918013310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918013311 Walker A motif; other site 205918013312 ATP binding site [chemical binding]; other site 205918013313 Walker B motif; other site 205918013314 arginine finger; other site 205918013315 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 205918013316 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 205918013317 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 205918013318 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 205918013319 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 205918013320 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918013321 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 205918013322 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013323 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013324 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013325 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013326 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918013327 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 205918013328 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 205918013329 Protein of unknown function (DUF402); Region: DUF402; cl00979 205918013330 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918013331 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 205918013332 rRNA binding site [nucleotide binding]; other site 205918013333 predicted 30S ribosome binding site; other site 205918013334 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 205918013335 Clp amino terminal domain; Region: Clp_N; pfam02861 205918013336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918013337 Walker A motif; other site 205918013338 ATP binding site [chemical binding]; other site 205918013339 Walker B motif; other site 205918013340 arginine finger; other site 205918013341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918013342 Walker A motif; other site 205918013343 ATP binding site [chemical binding]; other site 205918013344 Walker B motif; other site 205918013345 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 205918013346 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 205918013347 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 205918013348 DNA-binding site [nucleotide binding]; DNA binding site 205918013349 RNA-binding motif; other site 205918013350 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 205918013351 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918013352 LysR family transcriptional regulator; Provisional; Region: PRK14997 205918013353 Helix-turn-helix domains; Region: HTH; cl00088 205918013354 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 205918013355 putative effector binding pocket; other site 205918013356 putative dimerization interface [polypeptide binding]; other site 205918013357 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 205918013358 nudix motif; other site 205918013359 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 205918013360 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 205918013361 Protein of unknown function (DUF489); Region: DUF489; cl01097 205918013362 adenylosuccinate lyase; Provisional; Region: PRK09285 205918013363 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 205918013364 tetramer interface [polypeptide binding]; other site 205918013365 active site 205918013366 Uncharacterized conserved protein [Function unknown]; Region: COG2850 205918013367 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918013368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918013369 Coenzyme A binding pocket [chemical binding]; other site 205918013370 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 205918013371 1 probable transmembrane helix predicted by TMHMM2.0 205918013372 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 205918013373 tetramer interface [polypeptide binding]; other site 205918013374 active site 205918013375 Mg2+/Mn2+ binding site [ion binding]; other site 205918013376 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 205918013377 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013378 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013379 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013380 NADH dehydrogenase subunit B; Validated; Region: PRK06411 205918013381 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 205918013382 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 205918013383 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 205918013384 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 205918013385 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 205918013386 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 205918013387 putative dimer interface [polypeptide binding]; other site 205918013388 [2Fe-2S] cluster binding site [ion binding]; other site 205918013389 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 205918013390 SLBB domain; Region: SLBB; pfam10531 205918013391 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 205918013392 NADH dehydrogenase subunit G; Validated; Region: PRK08166 205918013393 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205918013394 catalytic loop [active] 205918013395 iron binding site [ion binding]; other site 205918013396 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 205918013397 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 205918013398 [4Fe-4S] binding site [ion binding]; other site 205918013399 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 205918013400 NADH dehydrogenase; Region: NADHdh; cl00469 205918013401 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013402 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013403 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013404 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013405 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013406 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013407 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013408 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013409 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 205918013410 4Fe-4S binding domain; Region: Fer4; cl02805 205918013411 4Fe-4S binding domain; Region: Fer4; cl02805 205918013412 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 205918013413 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 205918013414 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013415 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013416 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013417 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013418 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013419 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 205918013420 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013421 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013422 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013423 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 205918013424 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 205918013425 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 205918013426 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013427 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013428 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013429 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013430 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013431 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013432 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013433 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013434 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013435 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013436 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013437 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013438 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013439 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013440 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013441 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918013442 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 205918013443 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 205918013444 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013445 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013446 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013447 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013448 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013449 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013450 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013451 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013452 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013453 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013454 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013455 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013456 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013457 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013458 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 205918013459 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 205918013460 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013461 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013462 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013463 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013464 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013465 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013466 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013467 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013468 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013469 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013470 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013471 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013472 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013473 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918013474 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 205918013475 Domain of unknown function DUF20; Region: UPF0118; pfam01594 205918013476 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013477 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013478 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013479 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013480 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013481 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013482 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918013483 sensor protein PhoQ; Provisional; Region: PRK10815 205918013484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918013485 ATP binding site [chemical binding]; other site 205918013486 Mg2+ binding site [ion binding]; other site 205918013487 G-X-G motif; other site 205918013488 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013489 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013490 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 205918013491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918013492 active site 205918013493 phosphorylation site [posttranslational modification] 205918013494 intermolecular recognition site; other site 205918013495 dimerization interface [polypeptide binding]; other site 205918013496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918013497 DNA binding site [nucleotide binding] 205918013498 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 205918013499 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 205918013500 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 205918013501 active site 205918013502 threonine and homoserine efflux system; Provisional; Region: PRK10532 205918013503 EamA-like transporter family; Region: EamA; cl01037 205918013504 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013505 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013506 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013507 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013508 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013509 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013510 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013511 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013512 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013513 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013514 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 205918013515 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 205918013516 active site 205918013517 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 205918013518 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205918013519 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918013520 catalytic residue [active] 205918013521 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 205918013522 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 205918013523 inhibitor-cofactor binding pocket; inhibition site 205918013524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918013525 catalytic residue [active] 205918013526 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 205918013527 MatE; Region: MatE; cl10513 205918013528 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013529 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013530 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013531 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013532 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013533 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013534 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013535 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013536 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013537 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013538 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013539 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013540 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013541 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205918013542 active site 205918013543 Low molecular weight phosphatase family; Region: LMWPc; cd00115 205918013544 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 205918013545 active site 205918013546 tyrosine kinase; Provisional; Region: PRK11519 205918013547 Chain length determinant protein; Region: Wzz; cl15801 205918013548 Chain length determinant protein; Region: Wzz; cl15801 205918013549 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 205918013550 Nucleotide binding site [chemical binding]; other site 205918013551 P loop; other site 205918013552 DTAP/Switch II; other site 205918013553 Switch I; other site 205918013554 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013555 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013556 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 205918013557 transcriptional activator RfaH; Region: RfaH; TIGR01955 205918013558 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 205918013559 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918013560 active site 205918013561 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918013562 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 205918013563 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918013564 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 205918013565 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918013566 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 205918013567 putative ADP-binding pocket [chemical binding]; other site 205918013568 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 205918013569 Bacterial sugar transferase; Region: Bac_transf; cl00939 205918013570 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013571 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013572 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013573 polysaccharide export protein Wza; Provisional; Region: PRK15078 205918013574 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 205918013575 SLBB domain; Region: SLBB; pfam10531 205918013576 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 205918013577 LysE type translocator; Region: LysE; cl00565 205918013578 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013579 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013580 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013581 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013582 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013583 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918013584 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 205918013585 catalytic residue [active] 205918013586 1 probable transmembrane helix predicted by TMHMM2.0 205918013587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918013588 Helix-turn-helix domains; Region: HTH; cl00088 205918013589 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 205918013590 putative dimerization interface [polypeptide binding]; other site 205918013591 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 205918013592 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 205918013593 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 205918013594 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013595 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013596 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013597 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013598 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013599 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013600 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013601 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013602 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013603 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013604 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 205918013605 conserved cys residue [active] 205918013606 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 205918013607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918013608 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 205918013609 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 205918013610 active site 205918013611 catalytic site [active] 205918013612 metal binding site [ion binding]; metal-binding site 205918013613 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918013614 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918013615 N-terminal plug; other site 205918013616 ligand-binding site [chemical binding]; other site 205918013617 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 205918013618 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 205918013619 domain interface [polypeptide binding]; other site 205918013620 putative active site [active] 205918013621 catalytic site [active] 205918013622 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 205918013623 domain interface [polypeptide binding]; other site 205918013624 putative active site [active] 205918013625 catalytic site [active] 205918013626 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 205918013627 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 205918013628 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 205918013629 active site 205918013630 DNA binding site [nucleotide binding] 205918013631 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 205918013632 DNA binding site [nucleotide binding] 205918013633 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 205918013634 nucleotide binding site [chemical binding]; other site 205918013635 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 205918013636 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 205918013637 putative DNA binding site [nucleotide binding]; other site 205918013638 putative homodimer interface [polypeptide binding]; other site 205918013639 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 205918013640 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 205918013641 active site 205918013642 dimer interface [polypeptide binding]; other site 205918013643 non-prolyl cis peptide bond; other site 205918013644 insertion regions; other site 205918013645 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 205918013646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918013647 Walker A motif; other site 205918013648 ATP binding site [chemical binding]; other site 205918013649 Walker B motif; other site 205918013650 arginine finger; other site 205918013651 Helix-turn-helix domains; Region: HTH; cl00088 205918013652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 205918013653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918013654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918013655 non-specific DNA binding site [nucleotide binding]; other site 205918013656 salt bridge; other site 205918013657 sequence-specific DNA binding site [nucleotide binding]; other site 205918013658 Cupin domain; Region: Cupin_2; cl09118 205918013659 EamA-like transporter family; Region: EamA; cl01037 205918013660 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 205918013661 EamA-like transporter family; Region: EamA; cl01037 205918013662 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013663 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013664 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013665 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013666 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013667 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013668 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013669 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013670 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 205918013671 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 205918013672 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 205918013673 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 205918013674 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 205918013675 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 205918013676 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013677 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013678 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013679 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013680 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013681 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013682 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013683 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013684 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013685 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013686 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013687 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013688 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013689 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013690 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013691 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013692 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013693 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013694 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013695 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013696 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013697 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013698 1 of 23 probable transmembrane helices predicted by TMHMM2.0 205918013699 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 205918013700 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013701 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013702 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013703 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 205918013704 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 205918013705 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013706 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013707 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013708 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013709 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013710 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013711 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013712 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013713 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013714 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013715 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013716 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013717 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013718 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013719 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918013720 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 205918013721 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013722 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013723 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 205918013724 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013725 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013726 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013727 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 205918013728 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013729 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013730 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918013731 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 205918013732 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 205918013733 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918013734 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918013735 dimer interface [polypeptide binding]; other site 205918013736 putative CheW interface [polypeptide binding]; other site 205918013737 1 probable transmembrane helix predicted by TMHMM2.0 205918013738 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 205918013739 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 205918013740 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205918013741 TM-ABC transporter signature motif; other site 205918013742 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013743 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013744 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013745 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013746 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013747 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013748 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013749 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013750 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 205918013751 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 205918013752 Walker A/P-loop; other site 205918013753 ATP binding site [chemical binding]; other site 205918013754 Q-loop/lid; other site 205918013755 ABC transporter signature motif; other site 205918013756 Walker B; other site 205918013757 D-loop; other site 205918013758 H-loop/switch region; other site 205918013759 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 205918013760 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 205918013761 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 205918013762 putative ligand binding site [chemical binding]; other site 205918013763 putative oxidoreductase; Provisional; Region: PRK11579 205918013764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918013765 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 205918013766 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 205918013767 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 205918013768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918013769 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 205918013770 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 205918013771 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 205918013772 PYR/PP interface [polypeptide binding]; other site 205918013773 dimer interface [polypeptide binding]; other site 205918013774 TPP binding site [chemical binding]; other site 205918013775 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 205918013776 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 205918013777 TPP-binding site; other site 205918013778 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 205918013779 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 205918013780 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918013781 tetrameric interface [polypeptide binding]; other site 205918013782 NAD binding site [chemical binding]; other site 205918013783 catalytic residues [active] 205918013784 KduI/IolB family; Region: KduI; cl01508 205918013785 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 205918013786 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205918013787 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 205918013788 substrate binding site [chemical binding]; other site 205918013789 ATP binding site [chemical binding]; other site 205918013790 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 205918013791 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 205918013792 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 205918013793 putative active site [active] 205918013794 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 205918013795 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013796 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013797 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013798 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013799 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013800 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013801 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013802 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918013803 cardiolipin synthase 2; Provisional; Region: PRK11263 205918013804 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 205918013805 putative active site [active] 205918013806 catalytic site [active] 205918013807 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 205918013808 putative active site [active] 205918013809 catalytic site [active] 205918013810 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 205918013811 putative catalytic site [active] 205918013812 putative metal binding site [ion binding]; other site 205918013813 putative phosphate binding site [ion binding]; other site 205918013814 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 205918013815 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013816 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013817 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013818 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918013819 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 205918013820 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 205918013821 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 205918013822 Helix-turn-helix domains; Region: HTH; cl00088 205918013823 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 205918013824 LexA repressor; Validated; Region: PRK00215 205918013825 Helix-turn-helix domains; Region: HTH; cl00088 205918013826 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918013827 Catalytic site [active] 205918013828 Cell division inhibitor SulA; Region: SulA; cl01880 205918013829 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 205918013830 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 205918013831 active site 205918013832 interdomain interaction site; other site 205918013833 putative metal-binding site [ion binding]; other site 205918013834 nucleotide binding site [chemical binding]; other site 205918013835 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 205918013836 domain I; other site 205918013837 DNA binding groove [nucleotide binding] 205918013838 phosphate binding site [ion binding]; other site 205918013839 domain II; other site 205918013840 domain III; other site 205918013841 nucleotide binding site [chemical binding]; other site 205918013842 catalytic site [active] 205918013843 domain IV; other site 205918013844 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 205918013845 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 205918013846 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 205918013847 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 205918013848 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 205918013849 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 205918013850 dimer interface [polypeptide binding]; other site 205918013851 active site 205918013852 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 205918013853 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 205918013854 substrate binding site [chemical binding]; other site 205918013855 oxyanion hole (OAH) forming residues; other site 205918013856 trimer interface [polypeptide binding]; other site 205918013857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918013858 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 205918013859 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 205918013860 1 probable transmembrane helix predicted by TMHMM2.0 205918013861 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205918013862 Ligand Binding Site [chemical binding]; other site 205918013863 ABC transporter ATPase component; Reviewed; Region: PRK11147 205918013864 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 205918013865 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 205918013866 ABC transporter; Region: ABC_tran_2; pfam12848 205918013867 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 205918013868 lytic murein transglycosylase; Provisional; Region: PRK11619 205918013869 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 205918013870 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918013871 catalytic residue [active] 205918013872 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 205918013873 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 205918013874 MOSC domain; Region: MOSC; pfam03473 205918013875 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 205918013876 Response regulator receiver domain; Region: Response_reg; pfam00072 205918013877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918013878 active site 205918013879 phosphorylation site [posttranslational modification] 205918013880 intermolecular recognition site; other site 205918013881 dimerization interface [polypeptide binding]; other site 205918013882 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918013883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918013884 active site 205918013885 phosphorylation site [posttranslational modification] 205918013886 intermolecular recognition site; other site 205918013887 dimerization interface [polypeptide binding]; other site 205918013888 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918013889 DNA binding residues [nucleotide binding] 205918013890 lipid kinase; Reviewed; Region: PRK13054 205918013891 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 205918013892 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 205918013893 Bacterial sugar transferase; Region: Bac_transf; cl00939 205918013894 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013895 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013896 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013897 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013898 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918013899 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 205918013900 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 205918013901 Substrate binding site; other site 205918013902 Cupin domain; Region: Cupin_2; cl09118 205918013903 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 205918013904 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 205918013905 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 205918013906 Chain length determinant protein; Region: Wzz; cl15801 205918013907 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 205918013908 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013909 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918013910 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 205918013911 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 205918013912 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 205918013913 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 205918013914 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 205918013915 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205918013916 O-Antigen ligase; Region: Wzy_C; cl04850 205918013917 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013918 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013919 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013920 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013921 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013922 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013923 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013924 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013925 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013926 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013927 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013928 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013929 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918013930 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 205918013931 trimer interface [polypeptide binding]; other site 205918013932 active site 205918013933 substrate binding site [chemical binding]; other site 205918013934 CoA binding site [chemical binding]; other site 205918013935 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 205918013936 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013937 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013938 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013939 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013940 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013941 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013942 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013943 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013944 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013945 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013946 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013947 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013948 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 205918013949 Helix-turn-helix domains; Region: HTH; cl00088 205918013950 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 205918013951 putative dimerization interface [polypeptide binding]; other site 205918013952 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 205918013953 gating phenylalanine in ion channel; other site 205918013954 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013955 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013956 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013957 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013958 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013959 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013960 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013961 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013962 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013963 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918013964 Helix-turn-helix domains; Region: HTH; cl00088 205918013965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918013966 putative transposase OrfB; Reviewed; Region: PHA02517 205918013967 HTH-like domain; Region: HTH_21; pfam13276 205918013968 Integrase core domain; Region: rve; cl01316 205918013969 Integrase core domain; Region: rve_3; cl15866 205918013970 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 205918013971 active site 205918013972 catalytic residues [active] 205918013973 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 205918013974 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 205918013975 potential catalytic triad [active] 205918013976 conserved cys residue [active] 205918013977 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918013978 Helix-turn-helix domains; Region: HTH; cl00088 205918013979 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 205918013980 substrate binding pocket [chemical binding]; other site 205918013981 dimerization interface [polypeptide binding]; other site 205918013982 putative cyanate transporter; Provisional; Region: cynX; PRK09705 205918013983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918013984 putative substrate translocation pore; other site 205918013985 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013986 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013987 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013988 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013989 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013990 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013991 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013992 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013993 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013994 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013995 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013996 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918013997 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 205918013998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918013999 Helix-turn-helix domains; Region: HTH; cl00088 205918014000 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 205918014001 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 205918014002 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 205918014003 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 205918014004 Cupin domain; Region: Cupin_2; cl09118 205918014005 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205918014006 Helix-turn-helix domains; Region: HTH; cl00088 205918014007 Bacterial transcriptional regulator; Region: IclR; pfam01614 205918014008 Cache domain; Region: Cache_1; pfam02743 205918014009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918014010 metal binding site [ion binding]; metal-binding site 205918014011 active site 205918014012 I-site; other site 205918014013 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014014 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014015 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014016 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014017 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 205918014018 GAF domain; Region: GAF; cl15785 205918014019 PAS domain S-box; Region: sensory_box; TIGR00229 205918014020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918014021 putative active site [active] 205918014022 heme pocket [chemical binding]; other site 205918014023 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918014024 metal binding site [ion binding]; metal-binding site 205918014025 active site 205918014026 I-site; other site 205918014027 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918014028 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 205918014029 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 205918014030 dimer interface [polypeptide binding]; other site 205918014031 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 205918014032 active site 205918014033 Fe binding site [ion binding]; other site 205918014034 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 205918014035 FAD binding domain; Region: FAD_binding_4; pfam01565 205918014036 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 205918014037 FAD binding domain; Region: FAD_binding_4; pfam01565 205918014038 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 205918014039 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 205918014040 Cysteine-rich domain; Region: CCG; pfam02754 205918014041 Cysteine-rich domain; Region: CCG; pfam02754 205918014042 Domain of unknown function (DUF336); Region: DUF336; cl01249 205918014043 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 205918014044 structural tetrad; other site 205918014045 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205918014046 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205918014047 DNA binding site [nucleotide binding] 205918014048 domain linker motif; other site 205918014049 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 205918014050 putative dimerization interface [polypeptide binding]; other site 205918014051 putative ligand binding site [chemical binding]; other site 205918014052 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 205918014053 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 205918014054 ATP-binding site [chemical binding]; other site 205918014055 Gluconate-6-phosphate binding site [chemical binding]; other site 205918014056 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 205918014057 GntP family permease; Region: GntP_permease; pfam02447 205918014058 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014059 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014060 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014061 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014062 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014063 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014064 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014065 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014066 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014067 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014068 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014069 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014070 Global regulator protein family; Region: CsrA; cl00670 205918014071 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 205918014072 1 probable transmembrane helix predicted by TMHMM2.0 205918014073 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 205918014074 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 205918014075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918014076 Coenzyme A binding pocket [chemical binding]; other site 205918014077 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918014078 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 205918014079 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918014080 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918014081 N-terminal plug; other site 205918014082 ligand-binding site [chemical binding]; other site 205918014083 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 205918014084 Helix-turn-helix domains; Region: HTH; cl00088 205918014085 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 205918014086 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918014087 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 205918014088 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918014089 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918014090 dimer interface [polypeptide binding]; other site 205918014091 putative CheW interface [polypeptide binding]; other site 205918014092 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014093 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014094 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 205918014095 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 205918014096 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 205918014097 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918014098 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 205918014099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918014100 dimerization interface [polypeptide binding]; other site 205918014101 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918014102 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918014103 dimer interface [polypeptide binding]; other site 205918014104 putative CheW interface [polypeptide binding]; other site 205918014105 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014106 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014107 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918014108 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 205918014109 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 205918014110 tetramer interface [polypeptide binding]; other site 205918014111 heme binding pocket [chemical binding]; other site 205918014112 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 205918014113 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 205918014114 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 205918014115 PAS fold; Region: PAS_4; pfam08448 205918014116 sensory histidine kinase AtoS; Provisional; Region: PRK11360 205918014117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918014118 dimer interface [polypeptide binding]; other site 205918014119 phosphorylation site [posttranslational modification] 205918014120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918014121 ATP binding site [chemical binding]; other site 205918014122 Mg2+ binding site [ion binding]; other site 205918014123 G-X-G motif; other site 205918014124 Response regulator receiver domain; Region: Response_reg; pfam00072 205918014125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014126 active site 205918014127 phosphorylation site [posttranslational modification] 205918014128 intermolecular recognition site; other site 205918014129 dimerization interface [polypeptide binding]; other site 205918014130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918014131 Helix-turn-helix domains; Region: HTH; cl00088 205918014132 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918014133 dimerization interface [polypeptide binding]; other site 205918014134 Predicted membrane protein [Function unknown]; Region: COG4125 205918014135 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 205918014136 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 205918014137 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014138 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014139 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014140 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014141 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 205918014142 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014143 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014144 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014145 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014146 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014147 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014148 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014149 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014150 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014151 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014152 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014153 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014154 Predicted permeases [General function prediction only]; Region: RarD; COG2962 205918014155 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014156 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014157 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014158 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014159 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014160 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014161 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014162 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014163 Predicted ATPase [General function prediction only]; Region: COG1485 205918014164 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 205918014165 Sulfate transporter family; Region: Sulfate_transp; cl15842 205918014166 Sulfate transporter family; Region: Sulfate_transp; cl15842 205918014167 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 205918014168 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014169 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014170 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014171 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014172 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014173 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014174 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014175 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014176 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014177 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014178 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014179 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014180 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918014181 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 205918014182 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 205918014183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918014184 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 205918014185 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 205918014186 DNA binding site [nucleotide binding] 205918014187 active site 205918014188 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 205918014189 endonuclease III; Region: ENDO3c; smart00478 205918014190 minor groove reading motif; other site 205918014191 helix-hairpin-helix signature motif; other site 205918014192 substrate binding pocket [chemical binding]; other site 205918014193 active site 205918014194 Iron permease FTR1 family; Region: FTR1; cl00475 205918014195 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014196 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014197 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014198 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014199 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014200 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014201 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014202 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 205918014203 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 205918014204 Imelysin; Region: Peptidase_M75; cl09159 205918014205 1 probable transmembrane helix predicted by TMHMM2.0 205918014206 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 205918014207 Imelysin; Region: Peptidase_M75; cl09159 205918014208 1 probable transmembrane helix predicted by TMHMM2.0 205918014209 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 205918014210 Moco binding site; other site 205918014211 metal coordination site [ion binding]; other site 205918014212 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 205918014213 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014214 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014215 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014216 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014217 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 205918014218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014219 active site 205918014220 phosphorylation site [posttranslational modification] 205918014221 intermolecular recognition site; other site 205918014222 dimerization interface [polypeptide binding]; other site 205918014223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918014224 DNA binding site [nucleotide binding] 205918014225 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 205918014226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918014227 dimer interface [polypeptide binding]; other site 205918014228 phosphorylation site [posttranslational modification] 205918014229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918014230 ATP binding site [chemical binding]; other site 205918014231 Mg2+ binding site [ion binding]; other site 205918014232 G-X-G motif; other site 205918014233 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014234 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014235 Alginate lyase; Region: Alginate_lyase2; pfam08787 205918014236 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 205918014237 Helix-turn-helix domains; Region: HTH; cl00088 205918014238 Fusaric acid resistance protein family; Region: FUSC; pfam04632 205918014239 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 205918014240 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014241 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014242 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014243 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014244 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014245 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014246 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014247 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014248 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014249 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918014250 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 205918014251 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014252 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014253 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 205918014254 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918014255 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918014256 1 probable transmembrane helix predicted by TMHMM2.0 205918014257 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918014258 Ion transport protein; Region: Ion_trans; pfam00520 205918014259 Ion channel; Region: Ion_trans_2; cl11596 205918014260 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014261 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014262 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014263 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014264 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014265 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014266 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918014267 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 205918014268 1 probable transmembrane helix predicted by TMHMM2.0 205918014269 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 205918014270 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 205918014271 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918014272 binding surface 205918014273 TPR motif; other site 205918014274 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014275 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014276 Cytochrome C biogenesis protein; Region: CcmH; cl01179 205918014277 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014278 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014279 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 205918014280 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 205918014281 catalytic residues [active] 205918014282 central insert; other site 205918014283 1 probable transmembrane helix predicted by TMHMM2.0 205918014284 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 205918014285 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014286 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014287 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014288 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014289 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014290 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014291 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014292 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014293 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014294 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014295 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014296 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014297 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014298 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014299 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918014300 CcmE; Region: CcmE; cl00994 205918014301 1 probable transmembrane helix predicted by TMHMM2.0 205918014302 Heme exporter protein D (CcmD); Region: CcmD; cl11475 205918014303 1 probable transmembrane helix predicted by TMHMM2.0 205918014304 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 205918014305 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014306 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014307 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014308 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014309 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014310 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014311 CcmB protein; Region: CcmB; cl01016 205918014312 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014313 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014314 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014315 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014316 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014317 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014318 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 205918014319 CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE...; Region: ABC_CcmA_heme_exporter; cd03231 205918014320 Walker A/P-loop; other site 205918014321 ATP binding site [chemical binding]; other site 205918014322 Q-loop/lid; other site 205918014323 ABC transporter signature motif; other site 205918014324 Walker B; other site 205918014325 D-loop; other site 205918014326 H-loop/switch region; other site 205918014327 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 205918014328 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 205918014329 recombination protein RecR; Reviewed; Region: recR; PRK00076 205918014330 RecR protein; Region: RecR; pfam02132 205918014331 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 205918014332 putative active site [active] 205918014333 putative metal-binding site [ion binding]; other site 205918014334 tetramer interface [polypeptide binding]; other site 205918014335 Helix-turn-helix domains; Region: HTH; cl00088 205918014336 transcriptional activator TtdR; Provisional; Region: PRK09801 205918014337 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 205918014338 putative effector binding pocket; other site 205918014339 putative dimerization interface [polypeptide binding]; other site 205918014340 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 205918014341 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 205918014342 dimer interface [polypeptide binding]; other site 205918014343 active site 205918014344 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918014345 substrate binding site [chemical binding]; other site 205918014346 catalytic residue [active] 205918014347 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 205918014348 homotrimer interaction site [polypeptide binding]; other site 205918014349 putative active site [active] 205918014350 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918014351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918014352 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918014353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918014354 Coenzyme A binding pocket [chemical binding]; other site 205918014355 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 205918014356 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918014357 NAD binding site [chemical binding]; other site 205918014358 catalytic residues [active] 205918014359 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 205918014360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918014361 aconitate hydratase; Validated; Region: PRK09277 205918014362 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 205918014363 substrate binding site [chemical binding]; other site 205918014364 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 205918014365 ligand binding site [chemical binding]; other site 205918014366 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 205918014367 substrate binding site [chemical binding]; other site 205918014368 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014369 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014370 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014371 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014372 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014373 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014374 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014375 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918014376 PAS domain; Region: PAS_9; pfam13426 205918014377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918014378 putative active site [active] 205918014379 heme pocket [chemical binding]; other site 205918014380 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918014381 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918014382 dimer interface [polypeptide binding]; other site 205918014383 putative CheW interface [polypeptide binding]; other site 205918014384 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014385 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014386 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 205918014387 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 205918014388 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 205918014389 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 205918014390 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 205918014391 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918014392 1 probable transmembrane helix predicted by TMHMM2.0 205918014393 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 205918014394 Low-spin heme binding site [chemical binding]; other site 205918014395 Putative water exit pathway; other site 205918014396 Binuclear center (active site) [active] 205918014397 Putative proton exit pathway; other site 205918014398 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014399 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014400 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014401 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014402 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014403 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014404 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014405 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014406 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014407 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014408 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014409 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014410 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 205918014411 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 205918014412 1 probable transmembrane helix predicted by TMHMM2.0 205918014413 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 205918014414 1 probable transmembrane helix predicted by TMHMM2.0 205918014415 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 205918014416 Cytochrome c; Region: Cytochrom_C; cl11414 205918014417 Cytochrome c; Region: Cytochrom_C; cl11414 205918014418 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014419 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014420 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 205918014421 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 205918014422 oligomeric interface; other site 205918014423 putative active site [active] 205918014424 homodimer interface [polypeptide binding]; other site 205918014425 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 205918014426 4Fe-4S binding domain; Region: Fer4_5; pfam12801 205918014427 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 205918014428 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 205918014429 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014430 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014431 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014432 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014433 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014434 FixH; Region: FixH; cl01254 205918014435 1 probable transmembrane helix predicted by TMHMM2.0 205918014436 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 205918014437 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 205918014438 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 205918014439 metal-binding site [ion binding] 205918014440 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205918014441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918014442 motif II; other site 205918014443 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014444 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014445 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014446 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014447 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014448 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014449 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014450 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 205918014451 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014452 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014453 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014454 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014455 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014456 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014457 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 205918014458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918014459 FeS/SAM binding site; other site 205918014460 HemN C-terminal domain; Region: HemN_C; pfam06969 205918014461 molecular chaperone DnaK; Provisional; Region: PRK13411 205918014462 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 205918014463 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 205918014464 ligand binding site [chemical binding]; other site 205918014465 flexible hinge region; other site 205918014466 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 205918014467 putative switch regulator; other site 205918014468 non-specific DNA interactions [nucleotide binding]; other site 205918014469 DNA binding site [nucleotide binding] 205918014470 sequence specific DNA binding site [nucleotide binding]; other site 205918014471 putative cAMP binding site [chemical binding]; other site 205918014472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918014473 active site 205918014474 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 205918014475 1 probable transmembrane helix predicted by TMHMM2.0 205918014476 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 205918014477 putative CheA interaction surface; other site 205918014478 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 205918014479 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205918014480 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918014481 P-loop; other site 205918014482 Magnesium ion binding site [ion binding]; other site 205918014483 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918014484 Magnesium ion binding site [ion binding]; other site 205918014485 flagellar motor protein MotD; Reviewed; Region: PRK09038 205918014486 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 205918014487 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918014488 ligand binding site [chemical binding]; other site 205918014489 1 probable transmembrane helix predicted by TMHMM2.0 205918014490 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 205918014491 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 205918014492 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014493 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014494 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014495 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014496 Response regulator receiver domain; Region: Response_reg; pfam00072 205918014497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014498 active site 205918014499 phosphorylation site [posttranslational modification] 205918014500 intermolecular recognition site; other site 205918014501 dimerization interface [polypeptide binding]; other site 205918014502 CheB methylesterase; Region: CheB_methylest; pfam01339 205918014503 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918014504 putative binding surface; other site 205918014505 active site 205918014506 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 205918014507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918014508 ATP binding site [chemical binding]; other site 205918014509 Mg2+ binding site [ion binding]; other site 205918014510 G-X-G motif; other site 205918014511 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 205918014512 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 205918014513 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 205918014514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014515 active site 205918014516 phosphorylation site [posttranslational modification] 205918014517 intermolecular recognition site; other site 205918014518 dimerization interface [polypeptide binding]; other site 205918014519 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 205918014520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918014521 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 205918014522 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918014523 DNA binding residues [nucleotide binding] 205918014524 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 205918014525 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918014526 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 205918014527 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 205918014528 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918014529 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 205918014530 FHIPEP family; Region: FHIPEP; pfam00771 205918014531 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014532 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014533 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014534 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014535 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014536 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014537 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918014538 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 205918014539 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 205918014540 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014541 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014542 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014543 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014544 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 205918014545 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014546 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014547 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014548 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014549 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014550 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014551 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 205918014552 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014553 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014554 FliP family; Region: FliP; cl00593 205918014555 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014556 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014557 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014558 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014559 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014560 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 205918014561 1 probable transmembrane helix predicted by TMHMM2.0 205918014562 flagellar motor switch protein; Validated; Region: fliN; PRK05698 205918014563 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 205918014564 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 205918014565 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 205918014566 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 205918014567 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014568 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014569 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 205918014570 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918014571 putative binding surface; other site 205918014572 active site 205918014573 Response regulator receiver domain; Region: Response_reg; pfam00072 205918014574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014575 active site 205918014576 phosphorylation site [posttranslational modification] 205918014577 intermolecular recognition site; other site 205918014578 dimerization interface [polypeptide binding]; other site 205918014579 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 205918014580 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 205918014581 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 205918014582 anti sigma factor interaction site; other site 205918014583 regulatory phosphorylation site [posttranslational modification]; other site 205918014584 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 205918014585 Flagellar FliJ protein; Region: FliJ; pfam02050 205918014586 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 205918014587 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 205918014588 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 205918014589 Walker A motif/ATP binding site; other site 205918014590 Walker B motif; other site 205918014591 flagellar assembly protein H; Validated; Region: fliH; PRK05687 205918014592 Flagellar assembly protein FliH; Region: FliH; pfam02108 205918014593 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 205918014594 MgtE intracellular N domain; Region: MgtE_N; cl15244 205918014595 FliG C-terminal domain; Region: FliG_C; pfam01706 205918014596 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 205918014597 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 205918014598 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 205918014599 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014600 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014601 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 205918014602 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918014603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014604 active site 205918014605 phosphorylation site [posttranslational modification] 205918014606 intermolecular recognition site; other site 205918014607 dimerization interface [polypeptide binding]; other site 205918014608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918014609 Walker A motif; other site 205918014610 ATP binding site [chemical binding]; other site 205918014611 Walker B motif; other site 205918014612 arginine finger; other site 205918014613 Helix-turn-helix domains; Region: HTH; cl00088 205918014614 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918014615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918014616 dimer interface [polypeptide binding]; other site 205918014617 phosphorylation site [posttranslational modification] 205918014618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918014619 ATP binding site [chemical binding]; other site 205918014620 Mg2+ binding site [ion binding]; other site 205918014621 G-X-G motif; other site 205918014622 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918014623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 205918014624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918014625 Walker A motif; other site 205918014626 ATP binding site [chemical binding]; other site 205918014627 Walker B motif; other site 205918014628 arginine finger; other site 205918014629 Helix-turn-helix domains; Region: HTH; cl00088 205918014630 Flagellar protein FliS; Region: FliS; cl00654 205918014631 flagellar capping protein; Reviewed; Region: fliD; PRK08032 205918014632 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 205918014633 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 205918014634 FlaG protein; Region: FlaG; cl00591 205918014635 flagellin; Provisional; Region: PRK12802 205918014636 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 205918014637 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 205918014638 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 205918014639 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 205918014640 dimer interface [polypeptide binding]; other site 205918014641 active site 205918014642 CoA binding pocket [chemical binding]; other site 205918014643 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918014644 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 205918014645 Probable Catalytic site; other site 205918014646 metal-binding site 205918014647 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205918014648 active site 205918014649 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918014650 active site 205918014651 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 205918014652 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918014653 active site 205918014654 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 205918014655 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717 205918014656 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 205918014657 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 205918014658 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 205918014659 Rod binding protein; Region: Rod-binding; cl01626 205918014660 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 205918014661 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 205918014662 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 205918014663 Flagellar L-ring protein; Region: FlgH; cl00905 205918014664 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 205918014665 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 205918014666 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 205918014667 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 205918014668 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 205918014669 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 205918014670 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 205918014671 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 205918014672 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 205918014673 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 205918014674 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 205918014675 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 205918014676 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 205918014677 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 205918014678 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 205918014679 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 205918014680 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 205918014681 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 205918014682 FlgD Ig-like domain; Region: FlgD_ig; cl15790 205918014683 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 205918014684 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 205918014685 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 205918014686 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 205918014687 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 205918014688 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 205918014689 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 205918014690 cyanate hydratase; Validated; Region: PRK02866 205918014691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 205918014692 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 205918014693 oligomer interface [polypeptide binding]; other site 205918014694 active site 205918014695 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 205918014696 Helix-turn-helix domains; Region: HTH; cl00088 205918014697 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 205918014698 dimerization interface [polypeptide binding]; other site 205918014699 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 205918014700 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 205918014701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918014702 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 205918014703 Response regulator receiver domain; Region: Response_reg; pfam00072 205918014704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014705 active site 205918014706 phosphorylation site [posttranslational modification] 205918014707 intermolecular recognition site; other site 205918014708 dimerization interface [polypeptide binding]; other site 205918014709 SAF-like; Region: SAF_2; pfam13144 205918014710 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 205918014711 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 205918014712 FlgN protein; Region: FlgN; cl09176 205918014713 Flagellar regulator YcgR; Region: YcgR; pfam07317 205918014714 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 205918014715 PilZ domain; Region: PilZ; cl01260 205918014716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918014717 putative substrate translocation pore; other site 205918014718 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918014719 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014720 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014721 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014722 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014723 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014724 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014725 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014726 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014727 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014728 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014729 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014730 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014731 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 205918014732 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205918014733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918014734 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205918014735 active site 205918014736 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918014737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918014738 ATP binding site [chemical binding]; other site 205918014739 Mg2+ binding site [ion binding]; other site 205918014740 G-X-G motif; other site 205918014741 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 205918014742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014743 active site 205918014744 phosphorylation site [posttranslational modification] 205918014745 intermolecular recognition site; other site 205918014746 dimerization interface [polypeptide binding]; other site 205918014747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918014748 TPR motif; other site 205918014749 binding surface 205918014750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918014751 binding surface 205918014752 TPR repeat; Region: TPR_11; pfam13414 205918014753 TPR motif; other site 205918014754 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 205918014755 SH3 domain-containing protein; Provisional; Region: PRK10884 205918014756 Bacterial SH3 domain; Region: SH3_3; cl02551 205918014757 1 probable transmembrane helix predicted by TMHMM2.0 205918014758 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 205918014759 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 205918014760 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 205918014761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918014762 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 205918014763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918014764 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 205918014765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918014766 putative substrate translocation pore; other site 205918014767 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014768 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014769 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014770 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014771 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014772 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014773 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014774 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014775 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014776 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014777 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014778 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918014779 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014780 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014781 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014782 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014783 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014784 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014785 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014786 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 205918014787 GAF domain; Region: GAF; cl15785 205918014788 Phytochrome region; Region: PHY; pfam00360 205918014789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918014790 dimer interface [polypeptide binding]; other site 205918014791 phosphorylation site [posttranslational modification] 205918014792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918014793 ATP binding site [chemical binding]; other site 205918014794 Mg2+ binding site [ion binding]; other site 205918014795 G-X-G motif; other site 205918014796 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 205918014797 heme binding pocket [chemical binding]; other site 205918014798 heme ligand [chemical binding]; other site 205918014799 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 205918014800 Sulfatase; Region: Sulfatase; cl10460 205918014801 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014802 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014803 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014804 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014805 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918014806 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014807 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014808 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014809 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014810 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014811 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918014812 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 205918014813 BNR repeat-like domain; Region: BNR_2; pfam13088 205918014814 1 probable transmembrane helix predicted by TMHMM2.0 205918014815 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 205918014816 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014817 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014818 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014819 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918014820 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 205918014821 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 205918014822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014823 active site 205918014824 phosphorylation site [posttranslational modification] 205918014825 intermolecular recognition site; other site 205918014826 dimerization interface [polypeptide binding]; other site 205918014827 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918014828 DNA binding site [nucleotide binding] 205918014829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918014830 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918014831 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918014832 dimer interface [polypeptide binding]; other site 205918014833 phosphorylation site [posttranslational modification] 205918014834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918014835 ATP binding site [chemical binding]; other site 205918014836 Mg2+ binding site [ion binding]; other site 205918014837 G-X-G motif; other site 205918014838 1 probable transmembrane helix predicted by TMHMM2.0 205918014839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918014840 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 205918014841 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918014842 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 205918014843 tetrameric interface [polypeptide binding]; other site 205918014844 NAD binding site [chemical binding]; other site 205918014845 catalytic residues [active] 205918014846 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 205918014847 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918014848 inhibitor-cofactor binding pocket; inhibition site 205918014849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918014850 catalytic residue [active] 205918014851 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 205918014852 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 205918014853 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 205918014854 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014855 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014856 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014857 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014858 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014859 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014860 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014861 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014862 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014863 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014864 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014865 Helix-turn-helix domains; Region: HTH; cl00088 205918014866 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918014867 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 205918014868 dimerization interface [polypeptide binding]; other site 205918014869 substrate binding pocket [chemical binding]; other site 205918014870 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 205918014871 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 205918014872 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 205918014873 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 205918014874 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 205918014875 metal binding site [ion binding]; metal-binding site 205918014876 putative dimer interface [polypeptide binding]; other site 205918014877 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918014878 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 205918014879 NAD(P) binding site [chemical binding]; other site 205918014880 catalytic residues [active] 205918014881 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 205918014882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918014883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918014884 Helix-turn-helix domains; Region: HTH; cl00088 205918014885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918014886 dimerization interface [polypeptide binding]; other site 205918014887 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 205918014888 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 205918014889 NAD binding site [chemical binding]; other site 205918014890 catalytic Zn binding site [ion binding]; other site 205918014891 structural Zn binding site [ion binding]; other site 205918014892 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 205918014893 Transcriptional regulators [Transcription]; Region: GntR; COG1802 205918014894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918014895 DNA-binding site [nucleotide binding]; DNA binding site 205918014896 FCD domain; Region: FCD; cl11656 205918014897 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 205918014898 Na binding site [ion binding]; other site 205918014899 putative substrate binding site [chemical binding]; other site 205918014900 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014901 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014902 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014903 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014904 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014905 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014906 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014907 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014908 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014909 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014910 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014911 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014912 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918014913 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918014914 putative active site [active] 205918014915 PAS fold; Region: PAS_3; pfam08447 205918014916 heme pocket [chemical binding]; other site 205918014917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918014918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918014919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918014920 dimer interface [polypeptide binding]; other site 205918014921 phosphorylation site [posttranslational modification] 205918014922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918014923 ATP binding site [chemical binding]; other site 205918014924 Mg2+ binding site [ion binding]; other site 205918014925 G-X-G motif; other site 205918014926 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 205918014927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918014928 active site 205918014929 phosphorylation site [posttranslational modification] 205918014930 intermolecular recognition site; other site 205918014931 dimerization interface [polypeptide binding]; other site 205918014932 Cache domain; Region: Cache_1; pfam02743 205918014933 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918014934 dimerization interface [polypeptide binding]; other site 205918014935 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918014936 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918014937 dimer interface [polypeptide binding]; other site 205918014938 putative CheW interface [polypeptide binding]; other site 205918014939 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014940 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918014941 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 205918014942 putative metal binding site [ion binding]; other site 205918014943 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 205918014944 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918014945 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918014946 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918014947 Helix-turn-helix domains; Region: HTH; cl00088 205918014948 WHG domain; Region: WHG; pfam13305 205918014949 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 205918014950 classical (c) SDRs; Region: SDR_c; cd05233 205918014951 NAD(P) binding site [chemical binding]; other site 205918014952 active site 205918014953 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 205918014954 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 205918014955 putative NAD(P) binding site [chemical binding]; other site 205918014956 short chain dehydrogenase; Provisional; Region: PRK06179 205918014957 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 205918014958 NADP binding site [chemical binding]; other site 205918014959 active site 205918014960 steroid binding site; other site 205918014961 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 205918014962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918014963 NAD(P) binding site [chemical binding]; other site 205918014964 active site 205918014965 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 205918014966 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 205918014967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918014968 Uncharacterized conserved protein [Function unknown]; Region: COG3268 205918014969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918014970 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 205918014971 NAD(P) binding site [chemical binding]; other site 205918014972 active site 205918014973 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 205918014974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918014975 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205918014976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918014977 Helix-turn-helix domains; Region: HTH; cl00088 205918014978 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918014979 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 205918014980 putative C-terminal domain interface [polypeptide binding]; other site 205918014981 putative GSH binding site (G-site) [chemical binding]; other site 205918014982 putative dimer interface [polypeptide binding]; other site 205918014983 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 205918014984 N-terminal domain interface [polypeptide binding]; other site 205918014985 dimer interface [polypeptide binding]; other site 205918014986 substrate binding pocket (H-site) [chemical binding]; other site 205918014987 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 205918014988 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 205918014989 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918014990 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014991 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014992 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014993 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014994 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014995 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014996 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014997 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014998 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918014999 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015000 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015001 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015002 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015003 Arc-like DNA binding domain; Region: Arc; pfam03869 205918015004 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 205918015005 MgtE intracellular N domain; Region: MgtE_N; cl15244 205918015006 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 205918015007 Divalent cation transporter; Region: MgtE; cl00786 205918015008 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015009 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015010 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015011 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015012 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015013 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 205918015014 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 205918015015 Global regulator protein family; Region: CsrA; cl00670 205918015016 aspartate kinase; Reviewed; Region: PRK06635 205918015017 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 205918015018 putative nucleotide binding site [chemical binding]; other site 205918015019 putative catalytic residues [active] 205918015020 putative Mg ion binding site [ion binding]; other site 205918015021 putative aspartate binding site [chemical binding]; other site 205918015022 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 205918015023 putative allosteric regulatory site; other site 205918015024 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 205918015025 putative allosteric regulatory residue; other site 205918015026 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 205918015027 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 205918015028 motif 1; other site 205918015029 active site 205918015030 motif 2; other site 205918015031 motif 3; other site 205918015032 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 205918015033 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 205918015034 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 205918015035 tetramer interface [polypeptide binding]; other site 205918015036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918015037 catalytic residue [active] 205918015038 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 205918015039 active site 205918015040 homopentamer interface [polypeptide binding]; other site 205918015041 dimer interface [polypeptide binding]; other site 205918015042 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 205918015043 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 205918015044 active site 205918015045 Zn binding site [ion binding]; other site 205918015046 Succinylarginine dihydrolase; Region: AstB; cl01511 205918015047 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918015048 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 205918015049 NAD(P) binding site [chemical binding]; other site 205918015050 catalytic residues [active] 205918015051 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 205918015052 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 205918015053 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 205918015054 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918015055 inhibitor-cofactor binding pocket; inhibition site 205918015056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918015057 catalytic residue [active] 205918015058 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 205918015059 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 205918015060 conserved cys residue [active] 205918015061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918015062 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918015063 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 205918015064 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 205918015065 Walker A/P-loop; other site 205918015066 ATP binding site [chemical binding]; other site 205918015067 Q-loop/lid; other site 205918015068 ABC transporter signature motif; other site 205918015069 Walker B; other site 205918015070 D-loop; other site 205918015071 H-loop/switch region; other site 205918015072 Predicted deacylase [General function prediction only]; Region: COG3608 205918015073 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 205918015074 active site 205918015075 Zn binding site [ion binding]; other site 205918015076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918015077 dimer interface [polypeptide binding]; other site 205918015078 conserved gate region; other site 205918015079 putative PBP binding loops; other site 205918015080 ABC-ATPase subunit interface; other site 205918015081 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015082 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015083 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015084 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015085 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015086 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918015087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918015088 dimer interface [polypeptide binding]; other site 205918015089 conserved gate region; other site 205918015090 putative PBP binding loops; other site 205918015091 ABC-ATPase subunit interface; other site 205918015092 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015093 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015094 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015095 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015096 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015097 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 205918015098 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918015099 substrate binding pocket [chemical binding]; other site 205918015100 membrane-bound complex binding site; other site 205918015101 hinge residues; other site 205918015102 acetyl-CoA synthetase; Provisional; Region: PRK00174 205918015103 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 205918015104 AMP-binding enzyme; Region: AMP-binding; cl15778 205918015105 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918015106 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 205918015107 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 205918015108 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 205918015109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918015110 Walker A motif; other site 205918015111 ATP binding site [chemical binding]; other site 205918015112 Walker B motif; other site 205918015113 arginine finger; other site 205918015114 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 205918015115 cofactor binding site; other site 205918015116 metal binding site [ion binding]; metal-binding site 205918015117 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 205918015118 aromatic arch; other site 205918015119 DCoH dimer interaction site [polypeptide binding]; other site 205918015120 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 205918015121 DCoH tetramer interaction site [polypeptide binding]; other site 205918015122 substrate binding site [chemical binding]; other site 205918015123 major facilitator superfamily transporter; Provisional; Region: PRK05122 205918015124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918015125 putative substrate translocation pore; other site 205918015126 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015127 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015128 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015129 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015130 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015131 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015132 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015133 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015134 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015135 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015136 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015137 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015138 RF-1 domain; Region: RF-1; cl02875 205918015139 aromatic amino acid transporter; Provisional; Region: PRK10238 205918015140 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015141 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015142 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015143 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015144 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015145 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015146 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015147 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015148 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015149 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015150 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015151 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015152 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 205918015153 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205918015154 RNA binding surface [nucleotide binding]; other site 205918015155 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 205918015156 probable active site [active] 205918015157 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 205918015158 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 205918015159 ScpA/B protein; Region: ScpA_ScpB; cl00598 205918015160 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 205918015161 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 205918015162 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 205918015163 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015164 Intracellular septation protein A; Region: IspA; cl01098 205918015165 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015166 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015167 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015168 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015169 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015170 YCII-related domain; Region: YCII; cl00999 205918015171 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 205918015172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015173 active site 205918015174 phosphorylation site [posttranslational modification] 205918015175 intermolecular recognition site; other site 205918015176 dimerization interface [polypeptide binding]; other site 205918015177 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918015178 DNA binding site [nucleotide binding] 205918015179 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 205918015180 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918015181 sensor protein QseC; Provisional; Region: PRK10337 205918015182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015183 ATP binding site [chemical binding]; other site 205918015184 G-X-G motif; other site 205918015185 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015186 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015187 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 205918015188 putative FMN binding site [chemical binding]; other site 205918015189 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 205918015190 Cation transport protein; Region: TrkH; cl10514 205918015191 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015192 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015193 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015194 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015195 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015196 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015197 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015198 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015199 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015200 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015201 Protein of unknown function (DUF962); Region: DUF962; cl01879 205918015202 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015203 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015204 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 205918015205 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 205918015206 putative active site [active] 205918015207 putative metal binding site [ion binding]; other site 205918015208 Rdx family; Region: Rdx; cl01407 205918015209 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 205918015210 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 205918015211 Walker A/P-loop; other site 205918015212 ATP binding site [chemical binding]; other site 205918015213 Q-loop/lid; other site 205918015214 ABC transporter signature motif; other site 205918015215 Walker B; other site 205918015216 D-loop; other site 205918015217 H-loop/switch region; other site 205918015218 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918015219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918015220 dimer interface [polypeptide binding]; other site 205918015221 conserved gate region; other site 205918015222 putative PBP binding loops; other site 205918015223 ABC-ATPase subunit interface; other site 205918015224 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015225 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015226 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015227 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015228 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015229 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015230 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015231 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015232 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 205918015233 active site 205918015234 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 205918015235 dimer interface [polypeptide binding]; other site 205918015236 non-prolyl cis peptide bond; other site 205918015237 insertion regions; other site 205918015238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918015239 Helix-turn-helix domains; Region: HTH; cl00088 205918015240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918015241 dimerization interface [polypeptide binding]; other site 205918015242 Cysteine dioxygenase type I; Region: CDO_I; cl15835 205918015243 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 205918015244 active site residue [active] 205918015245 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 205918015246 active site residue [active] 205918015247 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 205918015248 active site residue [active] 205918015249 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 205918015250 active site residue [active] 205918015251 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918015252 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918015253 substrate binding pocket [chemical binding]; other site 205918015254 membrane-bound complex binding site; other site 205918015255 hinge residues; other site 205918015256 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918015257 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 205918015258 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 205918015259 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 205918015260 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 205918015261 molybdopterin cofactor binding site [chemical binding]; other site 205918015262 substrate binding site [chemical binding]; other site 205918015263 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 205918015264 molybdopterin cofactor binding site; other site 205918015265 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 205918015266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918015267 substrate binding pocket [chemical binding]; other site 205918015268 membrane-bound complex binding site; other site 205918015269 hinge residues; other site 205918015270 LysR family transcriptional regulator; Provisional; Region: PRK14997 205918015271 Helix-turn-helix domains; Region: HTH; cl00088 205918015272 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918015273 putative effector binding pocket; other site 205918015274 dimerization interface [polypeptide binding]; other site 205918015275 Cupin domain; Region: Cupin_2; cl09118 205918015276 1 probable transmembrane helix predicted by TMHMM2.0 205918015277 GAF domain; Region: GAF; cl15785 205918015278 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 205918015279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918015280 Walker A motif; other site 205918015281 ATP binding site [chemical binding]; other site 205918015282 Walker B motif; other site 205918015283 biofilm formation regulator HmsP; Provisional; Region: PRK11829 205918015284 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 205918015285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918015286 dimer interface [polypeptide binding]; other site 205918015287 phosphorylation site [posttranslational modification] 205918015288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015289 ATP binding site [chemical binding]; other site 205918015290 Mg2+ binding site [ion binding]; other site 205918015291 G-X-G motif; other site 205918015292 Response regulator receiver domain; Region: Response_reg; pfam00072 205918015293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015294 active site 205918015295 phosphorylation site [posttranslational modification] 205918015296 intermolecular recognition site; other site 205918015297 dimerization interface [polypeptide binding]; other site 205918015298 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015299 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015300 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015301 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 205918015302 catalytic residues [active] 205918015303 dimer interface [polypeptide binding]; other site 205918015304 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 205918015305 SelR domain; Region: SelR; pfam01641 205918015306 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 205918015307 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918015308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918015309 homodimer interface [polypeptide binding]; other site 205918015310 catalytic residue [active] 205918015311 Peptidase family M48; Region: Peptidase_M48; cl12018 205918015312 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015313 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015314 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015315 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918015317 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 205918015318 putative active site [active] 205918015319 metal binding site [ion binding]; metal-binding site 205918015320 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 205918015321 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 205918015322 ATP binding site [chemical binding]; other site 205918015323 Mg++ binding site [ion binding]; other site 205918015324 motif III; other site 205918015325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918015326 nucleotide binding region [chemical binding]; other site 205918015327 ATP-binding site [chemical binding]; other site 205918015328 DbpA RNA binding domain; Region: DbpA; pfam03880 205918015329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918015330 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 205918015331 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 205918015332 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918015333 Helix-turn-helix domains; Region: HTH; cl00088 205918015334 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918015335 dimerization interface [polypeptide binding]; other site 205918015336 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 205918015337 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 205918015338 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015339 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015340 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015341 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015342 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015343 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015344 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015345 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015346 Transcriptional regulators [Transcription]; Region: MarR; COG1846 205918015347 Helix-turn-helix domains; Region: HTH; cl00088 205918015348 Helix-turn-helix domains; Region: HTH; cl00088 205918015349 OsmC-like protein; Region: OsmC; cl00767 205918015350 elongation factor P; Validated; Region: PRK00529 205918015351 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 205918015352 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 205918015353 RNA binding site [nucleotide binding]; other site 205918015354 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 205918015355 RNA binding site [nucleotide binding]; other site 205918015356 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823 205918015357 1 probable transmembrane helix predicted by TMHMM2.0 205918015358 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 205918015359 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 205918015360 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 205918015361 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015362 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015363 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015364 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015365 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015366 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015367 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015368 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015369 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015370 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015371 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015372 Helix-turn-helix domains; Region: HTH; cl00088 205918015373 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 205918015374 1 probable transmembrane helix predicted by TMHMM2.0 205918015375 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 205918015376 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 205918015377 NAD(P) binding site [chemical binding]; other site 205918015378 homodimer interface [polypeptide binding]; other site 205918015379 substrate binding site [chemical binding]; other site 205918015380 active site 205918015381 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015382 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015383 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015384 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 205918015385 Mg++ binding site [ion binding]; other site 205918015386 putative catalytic motif [active] 205918015387 putative substrate binding site [chemical binding]; other site 205918015388 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015389 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015390 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015391 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015392 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015393 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015394 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015395 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015396 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015397 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015398 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015399 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205918015400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918015401 NAD(P) binding site [chemical binding]; other site 205918015402 active site 205918015403 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 205918015404 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 205918015405 Beta-Casp domain; Region: Beta-Casp; cl12567 205918015406 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 205918015407 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015408 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015409 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 205918015410 IHF dimer interface [polypeptide binding]; other site 205918015411 IHF - DNA interface [nucleotide binding]; other site 205918015412 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 205918015413 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 205918015414 RNA binding site [nucleotide binding]; other site 205918015415 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 205918015416 RNA binding site [nucleotide binding]; other site 205918015417 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 205918015418 RNA binding site [nucleotide binding]; other site 205918015419 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205918015420 RNA binding site [nucleotide binding]; other site 205918015421 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205918015422 RNA binding site [nucleotide binding]; other site 205918015423 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 205918015424 RNA binding site [nucleotide binding]; other site 205918015425 cytidylate kinase; Provisional; Region: cmk; PRK00023 205918015426 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 205918015427 CMP-binding site; other site 205918015428 The sites determining sugar specificity; other site 205918015429 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 205918015430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918015431 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 205918015432 putative active site [active] 205918015433 1 probable transmembrane helix predicted by TMHMM2.0 205918015434 Chorismate mutase type II; Region: CM_2; cl00693 205918015435 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 205918015436 Prephenate dehydratase; Region: PDT; pfam00800 205918015437 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 205918015438 putative L-Phe binding site [chemical binding]; other site 205918015439 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 205918015440 homodimer interface [polypeptide binding]; other site 205918015441 substrate-cofactor binding pocket; other site 205918015442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918015443 catalytic residue [active] 205918015444 DNA gyrase subunit A; Validated; Region: PRK05560 205918015445 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 205918015446 CAP-like domain; other site 205918015447 active site 205918015448 primary dimer interface [polypeptide binding]; other site 205918015449 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205918015450 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205918015451 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205918015452 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205918015453 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205918015454 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205918015455 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 205918015456 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 205918015457 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 205918015458 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 205918015459 active site 205918015460 putative substrate binding pocket [chemical binding]; other site 205918015461 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 205918015462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918015463 S-adenosylmethionine binding site [chemical binding]; other site 205918015464 phosphoglycolate phosphatase; Provisional; Region: PRK13222 205918015465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918015466 motif II; other site 205918015467 short chain dehydrogenase; Provisional; Region: PRK08703 205918015468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918015469 NAD(P) binding site [chemical binding]; other site 205918015470 active site 205918015471 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918015472 metal binding site [ion binding]; metal-binding site 205918015473 active site 205918015474 I-site; other site 205918015475 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 205918015476 PAS domain S-box; Region: sensory_box; TIGR00229 205918015477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918015478 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918015479 metal binding site [ion binding]; metal-binding site 205918015480 active site 205918015481 I-site; other site 205918015482 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918015483 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015484 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015485 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205918015486 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205918015487 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918015488 Walker A/P-loop; other site 205918015489 ATP binding site [chemical binding]; other site 205918015490 Q-loop/lid; other site 205918015491 ABC transporter signature motif; other site 205918015492 Walker B; other site 205918015493 D-loop; other site 205918015494 H-loop/switch region; other site 205918015495 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015496 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015497 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015498 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015499 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918015500 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 205918015501 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 205918015502 catalytic residues [active] 205918015503 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 205918015504 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 205918015505 active site residue [active] 205918015506 BolA-like protein; Region: BolA; cl00386 205918015507 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 205918015508 fumarate hydratase; Provisional; Region: PRK12425 205918015509 Class II fumarases; Region: Fumarase_classII; cd01362 205918015510 active site 205918015511 tetramer interface [polypeptide binding]; other site 205918015512 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 205918015513 EamA-like transporter family; Region: EamA; cl01037 205918015514 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015515 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015516 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015517 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015518 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015519 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015520 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015521 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015522 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015523 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015524 DTW domain; Region: DTW; cl01221 205918015525 RmuC family; Region: RmuC; pfam02646 205918015526 1 probable transmembrane helix predicted by TMHMM2.0 205918015527 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015528 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015529 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918015530 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 205918015531 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 205918015532 catalytic residues [active] 205918015533 dimer interface [polypeptide binding]; other site 205918015534 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918015535 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015536 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015537 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015538 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015539 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015540 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015541 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015542 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015543 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015544 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015545 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015546 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015547 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 205918015548 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015549 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015550 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015551 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015552 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015553 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015554 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205918015555 catalytic core [active] 205918015556 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 205918015557 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 205918015558 putative dimer interface [polypeptide binding]; other site 205918015559 active site pocket [active] 205918015560 putative cataytic base [active] 205918015561 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 205918015562 homotrimer interface [polypeptide binding]; other site 205918015563 Walker A motif; other site 205918015564 GTP binding site [chemical binding]; other site 205918015565 Walker B motif; other site 205918015566 cobyric acid synthase; Provisional; Region: PRK00784 205918015567 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918015568 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918015569 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 205918015570 catalytic triad [active] 205918015571 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 205918015572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918015573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918015574 homodimer interface [polypeptide binding]; other site 205918015575 catalytic residue [active] 205918015576 CobD/Cbib protein; Region: CobD_Cbib; cl00561 205918015577 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015578 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015579 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 205918015580 putative FMN binding site [chemical binding]; other site 205918015581 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 205918015582 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918015583 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 205918015584 catalytic triad [active] 205918015585 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918015586 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 205918015587 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 205918015588 Walker A motif; other site 205918015589 homodimer interface [polypeptide binding]; other site 205918015590 ATP binding site [chemical binding]; other site 205918015591 hydroxycobalamin binding site [chemical binding]; other site 205918015592 Walker B motif; other site 205918015593 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 205918015594 NlpC/P60 family; Region: NLPC_P60; cl11438 205918015595 NlpC/P60 family; Region: NLPC_P60; cl11438 205918015596 NAD-dependent deacetylase; Provisional; Region: PRK00481 205918015597 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 205918015598 NAD+ binding site [chemical binding]; other site 205918015599 substrate binding site [chemical binding]; other site 205918015600 Zn binding site [ion binding]; other site 205918015601 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918015602 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 205918015603 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 205918015604 Domain of unknown function DUF20; Region: UPF0118; pfam01594 205918015605 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015606 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015607 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015608 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015609 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015610 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015611 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918015612 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 205918015613 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 205918015614 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 205918015615 dimerization interface [polypeptide binding]; other site 205918015616 putative ATP binding site [chemical binding]; other site 205918015617 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 205918015618 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 205918015619 active site 205918015620 substrate binding site [chemical binding]; other site 205918015621 cosubstrate binding site; other site 205918015622 catalytic site [active] 205918015623 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 205918015624 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 205918015625 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 205918015626 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 205918015627 homodimer interface [polypeptide binding]; other site 205918015628 metal binding site [ion binding]; metal-binding site 205918015629 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 205918015630 homodimer interface [polypeptide binding]; other site 205918015631 active site 205918015632 putative chemical substrate binding site [chemical binding]; other site 205918015633 metal binding site [ion binding]; metal-binding site 205918015634 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 205918015635 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205918015636 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 205918015637 synthetase active site [active] 205918015638 NTP binding site [chemical binding]; other site 205918015639 metal binding site [ion binding]; metal-binding site 205918015640 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 205918015641 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 205918015642 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 205918015643 TRAM domain; Region: TRAM; cl01282 205918015644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918015645 S-adenosylmethionine binding site [chemical binding]; other site 205918015646 cysteine synthase B; Region: cysM; TIGR01138 205918015647 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 205918015648 dimer interface [polypeptide binding]; other site 205918015649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918015650 catalytic residue [active] 205918015651 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 205918015652 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918015653 dimerization interface [polypeptide binding]; other site 205918015654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918015655 dimer interface [polypeptide binding]; other site 205918015656 phosphorylation site [posttranslational modification] 205918015657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015658 ATP binding site [chemical binding]; other site 205918015659 Mg2+ binding site [ion binding]; other site 205918015660 G-X-G motif; other site 205918015661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015662 active site 205918015663 phosphorylation site [posttranslational modification] 205918015664 intermolecular recognition site; other site 205918015665 dimerization interface [polypeptide binding]; other site 205918015666 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 205918015667 putative binding surface; other site 205918015668 active site 205918015669 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015670 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015671 META domain; Region: META; cl01245 205918015672 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 205918015673 catalytic residues [active] 205918015674 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 205918015675 ArsC family; Region: ArsC; pfam03960 205918015676 catalytic residues [active] 205918015677 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 205918015678 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 205918015679 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 205918015680 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 205918015681 Ligand Binding Site [chemical binding]; other site 205918015682 hypothetical protein; Provisional; Region: PRK04860 205918015683 SprT homologues; Region: SprT; cl01182 205918015684 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 205918015685 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 205918015686 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015687 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015688 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015689 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015690 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015691 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015692 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015693 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918015694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 205918015695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015696 ATP binding site [chemical binding]; other site 205918015697 Mg2+ binding site [ion binding]; other site 205918015698 G-X-G motif; other site 205918015699 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015700 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015701 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 205918015702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015703 active site 205918015704 phosphorylation site [posttranslational modification] 205918015705 intermolecular recognition site; other site 205918015706 dimerization interface [polypeptide binding]; other site 205918015707 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918015708 DNA binding site [nucleotide binding] 205918015709 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 205918015710 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918015711 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918015712 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 205918015713 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 205918015714 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 205918015715 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 205918015716 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 205918015717 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918015718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 205918015719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918015720 dimer interface [polypeptide binding]; other site 205918015721 phosphorylation site [posttranslational modification] 205918015722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015723 ATP binding site [chemical binding]; other site 205918015724 Mg2+ binding site [ion binding]; other site 205918015725 G-X-G motif; other site 205918015726 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015727 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015728 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 205918015729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918015730 active site 205918015731 phosphorylation site [posttranslational modification] 205918015732 intermolecular recognition site; other site 205918015733 dimerization interface [polypeptide binding]; other site 205918015734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918015735 DNA binding site [nucleotide binding] 205918015736 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 205918015737 ATP cone domain; Region: ATP-cone; pfam03477 205918015738 ATP cone domain; Region: ATP-cone; pfam03477 205918015739 Class I ribonucleotide reductase; Region: RNR_I; cd01679 205918015740 active site 205918015741 dimer interface [polypeptide binding]; other site 205918015742 catalytic residues [active] 205918015743 effector binding site; other site 205918015744 R2 peptide binding site; other site 205918015745 Fic/DOC family; Region: Fic; cl00960 205918015746 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 205918015747 dimer interface [polypeptide binding]; other site 205918015748 putative radical transfer pathway; other site 205918015749 diiron center [ion binding]; other site 205918015750 tyrosyl radical; other site 205918015751 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 205918015752 AMP-binding enzyme; Region: AMP-binding; cl15778 205918015753 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918015754 peptide synthase; Provisional; Region: PRK12467 205918015755 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918015756 AMP-binding enzyme; Region: AMP-binding; cl15778 205918015757 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918015758 AMP-binding enzyme; Region: AMP-binding; cl15778 205918015759 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918015760 peptide synthase; Provisional; Region: PRK12467 205918015761 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918015762 AMP-binding enzyme; Region: AMP-binding; cl15778 205918015763 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918015764 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918015765 AMP-binding enzyme; Region: AMP-binding; cl15778 205918015766 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918015767 peptide synthase; Provisional; Region: PRK12467 205918015768 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 205918015769 AMP-binding enzyme; Region: AMP-binding; cl15778 205918015770 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918015771 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 205918015772 Ribonucleotide reductase beta chain 205918015773 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 205918015774 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 205918015775 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 205918015776 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918015777 BRO family, N-terminal domain; Region: Bro-N; cl10591 205918015778 1 probable transmembrane helix predicted by TMHMM2.0 205918015779 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 205918015780 catalytic triad [active] 205918015781 putative active site [active] 205918015782 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 205918015783 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 205918015784 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 205918015785 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 205918015786 1 probable transmembrane helix predicted by TMHMM2.0 205918015787 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 205918015788 catalytic triad [active] 205918015789 putative active site [active] 205918015790 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 205918015791 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 205918015792 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 205918015793 PAS domain; Region: PAS_9; pfam13426 205918015794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918015795 putative active site [active] 205918015796 heme pocket [chemical binding]; other site 205918015797 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918015798 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918015799 dimer interface [polypeptide binding]; other site 205918015800 putative CheW interface [polypeptide binding]; other site 205918015801 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015802 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015803 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 205918015804 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918015805 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 205918015806 1 probable transmembrane helix predicted by TMHMM2.0 205918015807 transcriptional regulator SlyA; Provisional; Region: PRK03573 205918015808 Helix-turn-helix domains; Region: HTH; cl00088 205918015809 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 205918015810 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918015811 ATP binding site [chemical binding]; other site 205918015812 putative Mg++ binding site [ion binding]; other site 205918015813 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918015814 nucleotide binding region [chemical binding]; other site 205918015815 ATP-binding site [chemical binding]; other site 205918015816 RQC domain; Region: RQC; cl09632 205918015817 HRDC domain; Region: HRDC; cl02578 205918015818 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 205918015819 Protein of unknown function (DUF454); Region: DUF454; cl01063 205918015820 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015821 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015822 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 205918015823 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 205918015824 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 205918015825 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 205918015826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918015827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918015828 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205918015829 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205918015830 Walker A/P-loop; other site 205918015831 ATP binding site [chemical binding]; other site 205918015832 Q-loop/lid; other site 205918015833 ABC transporter signature motif; other site 205918015834 Walker B; other site 205918015835 D-loop; other site 205918015836 H-loop/switch region; other site 205918015837 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205918015838 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015839 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015840 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015841 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015842 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015843 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015844 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015845 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015846 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015847 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918015848 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 205918015849 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918015850 1 probable transmembrane helix predicted by TMHMM2.0 205918015851 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 205918015852 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 205918015853 active site 205918015854 dimer interface [polypeptide binding]; other site 205918015855 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 205918015856 Ligand Binding Site [chemical binding]; other site 205918015857 Molecular Tunnel; other site 205918015858 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 205918015859 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918015860 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918015861 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 205918015862 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 205918015863 putative oligomer interface [polypeptide binding]; other site 205918015864 putative active site [active] 205918015865 metal binding site [ion binding]; metal-binding site 205918015866 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 205918015867 Global regulator protein family; Region: CsrA; cl00670 205918015868 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 205918015869 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015870 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015871 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015872 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015873 short chain dehydrogenase; Provisional; Region: PRK05650 205918015874 classical (c) SDRs; Region: SDR_c; cd05233 205918015875 NAD(P) binding site [chemical binding]; other site 205918015876 active site 205918015877 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 205918015878 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015879 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015880 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 205918015881 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015882 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015883 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 205918015884 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 205918015885 Na binding site [ion binding]; other site 205918015886 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015887 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015888 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015889 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015890 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015891 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015892 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015893 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015894 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015895 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015896 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015897 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015898 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015899 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918015900 Protein of unknown function, DUF485; Region: DUF485; cl01231 205918015901 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015902 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918015903 NMT1-like family; Region: NMT1_2; cl15260 205918015904 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 205918015905 VacJ like lipoprotein; Region: VacJ; cl01073 205918015906 hypothetical protein; Provisional; Region: PRK11615 205918015907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918015908 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918015909 putative substrate translocation pore; other site 205918015910 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015911 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015912 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015913 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015914 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015915 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015916 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015917 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015918 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015919 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015920 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918015921 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 205918015922 MASE2 domain; Region: MASE2; pfam05230 205918015923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918015924 metal binding site [ion binding]; metal-binding site 205918015925 active site 205918015926 I-site; other site 205918015927 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015928 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015929 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015930 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015931 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918015932 DNA binding residues [nucleotide binding] 205918015933 dimerization interface [polypeptide binding]; other site 205918015934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918015935 metabolite-proton symporter; Region: 2A0106; TIGR00883 205918015936 putative substrate translocation pore; other site 205918015937 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015938 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015939 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015940 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015941 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015942 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015943 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015944 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015945 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015946 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015947 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015948 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918015949 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918015950 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918015951 N-terminal plug; other site 205918015952 ligand-binding site [chemical binding]; other site 205918015953 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 205918015954 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 205918015955 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 205918015956 GAF domain; Region: GAF; cl15785 205918015957 GAF domain; Region: GAF_2; pfam13185 205918015958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918015959 dimer interface [polypeptide binding]; other site 205918015960 phosphorylation site [posttranslational modification] 205918015961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015962 ATP binding site [chemical binding]; other site 205918015963 Mg2+ binding site [ion binding]; other site 205918015964 G-X-G motif; other site 205918015965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918015966 PAS domain; Region: PAS_9; pfam13426 205918015967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918015968 dimer interface [polypeptide binding]; other site 205918015969 phosphorylation site [posttranslational modification] 205918015970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918015971 ATP binding site [chemical binding]; other site 205918015972 Mg2+ binding site [ion binding]; other site 205918015973 G-X-G motif; other site 205918015974 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918015975 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 205918015976 nucleoside/Zn binding site; other site 205918015977 dimer interface [polypeptide binding]; other site 205918015978 catalytic motif [active] 205918015979 NMT1-like family; Region: NMT1_2; cl15260 205918015980 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 205918015981 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918015982 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918015983 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 205918015984 active site 205918015985 catalytic residues [active] 205918015986 metal binding site [ion binding]; metal-binding site 205918015987 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 205918015988 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015989 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015990 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015991 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015992 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015993 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918015994 CsbD-like; Region: CsbD; cl15799 205918015995 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 205918015996 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015997 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015998 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918015999 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016000 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 205918016001 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 205918016002 catalytic residues [active] 205918016003 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 205918016004 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205918016005 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205918016006 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 205918016007 helicase 45; Provisional; Region: PTZ00424 205918016008 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 205918016009 ATP binding site [chemical binding]; other site 205918016010 Mg++ binding site [ion binding]; other site 205918016011 motif III; other site 205918016012 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918016013 nucleotide binding region [chemical binding]; other site 205918016014 ATP-binding site [chemical binding]; other site 205918016015 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918016016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918016017 dimer interface [polypeptide binding]; other site 205918016018 phosphorylation site [posttranslational modification] 205918016019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918016020 ATP binding site [chemical binding]; other site 205918016021 Mg2+ binding site [ion binding]; other site 205918016022 G-X-G motif; other site 205918016023 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016024 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016025 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 205918016026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918016027 active site 205918016028 phosphorylation site [posttranslational modification] 205918016029 intermolecular recognition site; other site 205918016030 dimerization interface [polypeptide binding]; other site 205918016031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918016032 DNA binding site [nucleotide binding] 205918016033 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 205918016034 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 205918016035 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 205918016036 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 205918016037 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 205918016038 Surface antigen; Region: Bac_surface_Ag; cl03097 205918016039 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 205918016040 Helix-turn-helix domains; Region: HTH; cl00088 205918016041 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 205918016042 putative substrate binding pocket [chemical binding]; other site 205918016043 putative dimerization interface [polypeptide binding]; other site 205918016044 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 205918016045 Cyclophilin-like; Region: Cyclophil_like; cl00950 205918016046 1 probable transmembrane helix predicted by TMHMM2.0 205918016047 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 205918016048 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918016049 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 205918016050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918016051 putative substrate translocation pore; other site 205918016052 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016053 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016054 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016055 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016056 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016057 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016058 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016059 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016060 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016061 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016062 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016063 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016064 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918016065 Helix-turn-helix domains; Region: HTH; cl00088 205918016066 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 205918016067 putative effector binding pocket; other site 205918016068 putative dimerization interface [polypeptide binding]; other site 205918016069 1 probable transmembrane helix predicted by TMHMM2.0 205918016070 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918016071 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016072 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016073 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016074 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016075 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016076 DEAD-like helicases superfamily; Region: DEXDc; smart00487 205918016077 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918016078 ATP binding site [chemical binding]; other site 205918016079 putative Mg++ binding site [ion binding]; other site 205918016080 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918016081 nucleotide binding region [chemical binding]; other site 205918016082 ATP-binding site [chemical binding]; other site 205918016083 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 205918016084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918016085 active site 205918016086 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 205918016087 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 205918016088 Protein of unknown function (DUF3732); Region: DUF3732; pfam12532 205918016089 putative transposase OrfB; Reviewed; Region: PHA02517 205918016090 HTH-like domain; Region: HTH_21; pfam13276 205918016091 Integrase core domain; Region: rve; cl01316 205918016092 Integrase core domain; Region: rve_3; cl15866 205918016093 Helix-turn-helix domains; Region: HTH; cl00088 205918016094 mechanosensitive ion channel family protein 205918016095 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918016096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918016097 Coenzyme A binding pocket [chemical binding]; other site 205918016098 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 205918016099 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 205918016100 BRO family, N-terminal domain; Region: Bro-N; cl10591 205918016101 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 205918016102 classical (c) SDRs; Region: SDR_c; cd05233 205918016103 NAD(P) binding site [chemical binding]; other site 205918016104 active site 205918016105 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 205918016106 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016107 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016108 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016109 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016110 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016111 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016112 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016113 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016114 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016115 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016116 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 205918016117 Right handed beta helix region; Region: Beta_helix; pfam13229 205918016118 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918016119 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 205918016120 Cadherin repeat-like domain; Region: CA_like; cl15786 205918016121 Ca2+ binding site [ion binding]; other site 205918016122 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918016123 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918016124 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918016125 Helix-turn-helix domains; Region: HTH; cl00088 205918016126 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918016127 dimerization interface [polypeptide binding]; other site 205918016128 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 205918016129 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 205918016130 substrate binding site [chemical binding]; other site 205918016131 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205918016132 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205918016133 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918016134 Walker A/P-loop; other site 205918016135 ATP binding site [chemical binding]; other site 205918016136 Q-loop/lid; other site 205918016137 ABC transporter signature motif; other site 205918016138 Walker B; other site 205918016139 D-loop; other site 205918016140 H-loop/switch region; other site 205918016141 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016142 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016143 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016144 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016145 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016146 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918016147 Protein of unknown function, DUF482; Region: DUF482; pfam04339 205918016148 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 205918016149 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 205918016150 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 205918016151 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 205918016152 dimer interface [polypeptide binding]; other site 205918016153 active site 205918016154 CoA binding pocket [chemical binding]; other site 205918016155 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 205918016156 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918016157 ATP binding site [chemical binding]; other site 205918016158 putative Mg++ binding site [ion binding]; other site 205918016159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918016160 nucleotide binding region [chemical binding]; other site 205918016161 ATP-binding site [chemical binding]; other site 205918016162 Helicase associated domain (HA2); Region: HA2; cl04503 205918016163 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 205918016164 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 205918016165 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 205918016166 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 205918016167 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 205918016168 AMP-binding enzyme; Region: AMP-binding; cl15778 205918016169 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918016170 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 205918016171 AMP-binding enzyme; Region: AMP-binding; cl15778 205918016172 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918016173 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 205918016174 dimer interaction site [polypeptide binding]; other site 205918016175 substrate-binding tunnel; other site 205918016176 active site 205918016177 catalytic site [active] 205918016178 substrate binding site [chemical binding]; other site 205918016179 envelope glycoprotein C; Provisional; Region: PHA03269 205918016180 Pectate lyase; Region: Pec_lyase_C; cl01593 205918016181 ATP-dependent helicase HepA; Validated; Region: PRK04914 205918016182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918016183 ATP binding site [chemical binding]; other site 205918016184 putative Mg++ binding site [ion binding]; other site 205918016185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918016186 nucleotide binding region [chemical binding]; other site 205918016187 ATP-binding site [chemical binding]; other site 205918016188 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 205918016189 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 205918016190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918016191 metal binding site [ion binding]; metal-binding site 205918016192 active site 205918016193 I-site; other site 205918016194 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918016195 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016196 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016197 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016198 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016199 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016200 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016201 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 205918016202 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 205918016203 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 205918016204 dimerization interface [polypeptide binding]; other site 205918016205 ligand binding site [chemical binding]; other site 205918016206 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 205918016207 TM-ABC transporter signature motif; other site 205918016208 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016209 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016210 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016211 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016212 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016213 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016214 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016215 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918016216 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 205918016217 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 205918016218 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 205918016219 TM-ABC transporter signature motif; other site 205918016220 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016221 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016222 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016223 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016224 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016225 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016226 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016227 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016228 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016229 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016230 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 205918016231 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 205918016232 Walker A/P-loop; other site 205918016233 ATP binding site [chemical binding]; other site 205918016234 Q-loop/lid; other site 205918016235 ABC transporter signature motif; other site 205918016236 Walker B; other site 205918016237 D-loop; other site 205918016238 H-loop/switch region; other site 205918016239 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 205918016240 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 205918016241 Walker A/P-loop; other site 205918016242 ATP binding site [chemical binding]; other site 205918016243 Q-loop/lid; other site 205918016244 ABC transporter signature motif; other site 205918016245 Walker B; other site 205918016246 D-loop; other site 205918016247 H-loop/switch region; other site 205918016248 Predicted membrane protein [Function unknown]; Region: COG3650 205918016249 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 205918016250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918016251 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 205918016252 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016253 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016254 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 205918016255 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 205918016256 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 205918016257 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918016258 ligand binding site [chemical binding]; other site 205918016259 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918016260 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 205918016261 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918016262 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918016263 Copper resistance protein D; Region: CopD; cl00563 205918016264 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016265 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016266 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016267 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016268 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 205918016269 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 205918016270 1 probable transmembrane helix predicted by TMHMM2.0 205918016271 1 probable transmembrane helix predicted by TMHMM2.0 205918016272 Protein of unknown function (DUF1145); Region: DUF1145; cl11481 205918016273 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016274 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016275 ornithine cyclodeaminase; Validated; Region: PRK07340 205918016276 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918016277 dimerization interface [polypeptide binding]; other site 205918016278 hypothetical protein; Provisional; Region: PRK00183 205918016279 SEC-C motif; Region: SEC-C; pfam02810 205918016280 Secretin and TonB N terminus short domain; Region: STN; cl06624 205918016281 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918016282 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918016283 N-terminal plug; other site 205918016284 ligand-binding site [chemical binding]; other site 205918016285 Late embryogenesis abundant protein; Region: LEA_2; cl12118 205918016286 1 probable transmembrane helix predicted by TMHMM2.0 205918016287 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918016288 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918016289 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918016290 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 205918016291 Predicted transcriptional regulator [Transcription]; Region: COG2932 205918016292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918016293 non-specific DNA binding site [nucleotide binding]; other site 205918016294 salt bridge; other site 205918016295 sequence-specific DNA binding site [nucleotide binding]; other site 205918016296 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918016297 Catalytic site [active] 205918016298 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900 205918016299 SEC-C motif; Region: SEC-C; pfam02810 205918016300 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 205918016301 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 205918016302 active site 205918016303 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 205918016304 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 205918016305 ATP-dependent DNA ligase; Validated; Region: PRK09247 205918016306 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 205918016307 active site 205918016308 DNA binding site [nucleotide binding] 205918016309 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 205918016310 DNA binding site [nucleotide binding] 205918016311 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 205918016312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918016313 substrate binding pocket [chemical binding]; other site 205918016314 membrane-bound complex binding site; other site 205918016315 hinge residues; other site 205918016316 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918016317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918016318 dimer interface [polypeptide binding]; other site 205918016319 conserved gate region; other site 205918016320 putative PBP binding loops; other site 205918016321 ABC-ATPase subunit interface; other site 205918016322 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016323 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016324 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016325 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016326 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016327 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918016328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918016329 dimer interface [polypeptide binding]; other site 205918016330 conserved gate region; other site 205918016331 putative PBP binding loops; other site 205918016332 ABC-ATPase subunit interface; other site 205918016333 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016334 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016335 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016336 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016337 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016338 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 205918016339 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 205918016340 active site 205918016341 Zn binding site [ion binding]; other site 205918016342 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 205918016343 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 205918016344 Walker A/P-loop; other site 205918016345 ATP binding site [chemical binding]; other site 205918016346 Q-loop/lid; other site 205918016347 ABC transporter signature motif; other site 205918016348 Walker B; other site 205918016349 D-loop; other site 205918016350 H-loop/switch region; other site 205918016351 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 205918016352 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918016353 ATP binding site [chemical binding]; other site 205918016354 putative Mg++ binding site [ion binding]; other site 205918016355 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918016356 nucleotide binding region [chemical binding]; other site 205918016357 ATP-binding site [chemical binding]; other site 205918016358 DEAD/H associated; Region: DEAD_assoc; pfam08494 205918016359 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 205918016360 putative active site [active] 205918016361 putative metal binding site [ion binding]; other site 205918016362 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 205918016363 trimer interface [polypeptide binding]; other site 205918016364 active site 205918016365 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 205918016366 DNA-binding site [nucleotide binding]; DNA binding site 205918016367 RNA-binding motif; other site 205918016368 antiporter inner membrane protein; Provisional; Region: PRK11670 205918016369 Domain of unknown function DUF59; Region: DUF59; cl00941 205918016370 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 205918016371 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 205918016372 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 205918016373 active site 205918016374 HIGH motif; other site 205918016375 KMSKS motif; other site 205918016376 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 205918016377 tRNA binding surface [nucleotide binding]; other site 205918016378 anticodon binding site; other site 205918016379 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 205918016380 putative tRNA-binding site [nucleotide binding]; other site 205918016381 dimer interface [polypeptide binding]; other site 205918016382 electron transport complex protein RnfB; Provisional; Region: PRK05113 205918016383 Putative Fe-S cluster; Region: FeS; pfam04060 205918016384 4Fe-4S binding domain; Region: Fer4; cl02805 205918016385 electron transport complex protein RnfC; Provisional; Region: PRK05035 205918016386 endonuclease III; Provisional; Region: PRK10702 205918016387 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 205918016388 minor groove reading motif; other site 205918016389 helix-hairpin-helix signature motif; other site 205918016390 substrate binding pocket [chemical binding]; other site 205918016391 active site 205918016392 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 205918016393 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918016394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918016395 active site 205918016396 phosphorylation site [posttranslational modification] 205918016397 intermolecular recognition site; other site 205918016398 dimerization interface [polypeptide binding]; other site 205918016399 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918016400 DNA binding residues [nucleotide binding] 205918016401 dimerization interface [polypeptide binding]; other site 205918016402 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 205918016403 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 205918016404 ANP binding site [chemical binding]; other site 205918016405 Substrate Binding Site II [chemical binding]; other site 205918016406 Substrate Binding Site I [chemical binding]; other site 205918016407 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918016408 ligand binding site [chemical binding]; other site 205918016409 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 205918016410 active site 205918016411 substrate binding pocket [chemical binding]; other site 205918016412 dimer interface [polypeptide binding]; other site 205918016413 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 205918016414 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 205918016415 dimer interface [polypeptide binding]; other site 205918016416 catalytic site [active] 205918016417 putative active site [active] 205918016418 putative substrate binding site [chemical binding]; other site 205918016419 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 205918016420 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 205918016421 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 205918016422 heme binding site [chemical binding]; other site 205918016423 ferroxidase pore; other site 205918016424 ferroxidase diiron center [ion binding]; other site 205918016425 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 205918016426 putative GSH binding site [chemical binding]; other site 205918016427 catalytic residues [active] 205918016428 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 205918016429 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 205918016430 putative [Fe4-S4] binding site [ion binding]; other site 205918016431 putative molybdopterin cofactor binding site [chemical binding]; other site 205918016432 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 205918016433 putative molybdopterin cofactor binding site; other site 205918016434 ornithine carbamoyltransferase; Provisional; Region: PRK00779 205918016435 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 205918016436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918016437 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205918016438 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 205918016439 Walker A/P-loop; other site 205918016440 ATP binding site [chemical binding]; other site 205918016441 Q-loop/lid; other site 205918016442 ABC transporter signature motif; other site 205918016443 Walker B; other site 205918016444 D-loop; other site 205918016445 H-loop/switch region; other site 205918016446 TOBE domain; Region: TOBE_2; cl01440 205918016447 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 205918016448 putative deacylase active site [active] 205918016449 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 205918016450 amphipathic channel; other site 205918016451 Asn-Pro-Ala signature motifs; other site 205918016452 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016453 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016454 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016455 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016456 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016457 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016458 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016459 glycerol kinase; Provisional; Region: glpK; PRK00047 205918016460 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 205918016461 N- and C-terminal domain interface [polypeptide binding]; other site 205918016462 active site 205918016463 MgATP binding site [chemical binding]; other site 205918016464 catalytic site [active] 205918016465 metal binding site [ion binding]; metal-binding site 205918016466 glycerol binding site [chemical binding]; other site 205918016467 homotetramer interface [polypeptide binding]; other site 205918016468 homodimer interface [polypeptide binding]; other site 205918016469 protein IIAGlc interface [polypeptide binding]; other site 205918016470 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 205918016471 Helix-turn-helix domains; Region: HTH; cl00088 205918016472 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 205918016473 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 205918016474 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 205918016475 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918016476 substrate binding pocket [chemical binding]; other site 205918016477 membrane-bound complex binding site; other site 205918016478 hinge residues; other site 205918016479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918016480 dimer interface [polypeptide binding]; other site 205918016481 conserved gate region; other site 205918016482 putative PBP binding loops; other site 205918016483 ABC-ATPase subunit interface; other site 205918016484 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016485 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016486 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016487 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918016489 dimer interface [polypeptide binding]; other site 205918016490 conserved gate region; other site 205918016491 putative PBP binding loops; other site 205918016492 ABC-ATPase subunit interface; other site 205918016493 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016494 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016495 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016496 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016497 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016498 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918016499 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 205918016500 Walker A/P-loop; other site 205918016501 ATP binding site [chemical binding]; other site 205918016502 Q-loop/lid; other site 205918016503 ABC transporter signature motif; other site 205918016504 Walker B; other site 205918016505 D-loop; other site 205918016506 H-loop/switch region; other site 205918016507 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 205918016508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918016509 dimer interface [polypeptide binding]; other site 205918016510 phosphorylation site [posttranslational modification] 205918016511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918016512 ATP binding site [chemical binding]; other site 205918016513 Mg2+ binding site [ion binding]; other site 205918016514 G-X-G motif; other site 205918016515 1 probable transmembrane helix predicted by TMHMM2.0 205918016516 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918016517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918016518 active site 205918016519 phosphorylation site [posttranslational modification] 205918016520 intermolecular recognition site; other site 205918016521 dimerization interface [polypeptide binding]; other site 205918016522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918016523 Walker A motif; other site 205918016524 ATP binding site [chemical binding]; other site 205918016525 Walker B motif; other site 205918016526 arginine finger; other site 205918016527 Helix-turn-helix domains; Region: HTH; cl00088 205918016528 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 205918016529 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 205918016530 catalytic residues [active] 205918016531 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 205918016532 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 205918016533 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 205918016534 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 205918016535 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 205918016536 Helix-turn-helix domains; Region: HTH; cl00088 205918016537 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 205918016538 putative dimerization interface [polypeptide binding]; other site 205918016539 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 205918016540 nudix motif; other site 205918016541 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 205918016542 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 205918016543 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918016544 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 205918016545 OpgC protein; Region: OpgC_C; cl00792 205918016546 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918016547 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918016548 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918016549 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918016550 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918016551 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918016552 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918016553 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918016554 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918016555 1 probable transmembrane helix predicted by TMHMM2.0 205918016556 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 205918016557 Transglycosylase; Region: Transgly; cl07896 205918016558 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918016559 1 probable transmembrane helix predicted by TMHMM2.0 205918016560 Helix-turn-helix domains; Region: HTH; cl00088 205918016561 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 205918016562 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 205918016563 FAD binding pocket [chemical binding]; other site 205918016564 FAD binding motif [chemical binding]; other site 205918016565 phosphate binding motif [ion binding]; other site 205918016566 NAD binding pocket [chemical binding]; other site 205918016567 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016568 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016569 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016570 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016571 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016572 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918016573 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 205918016574 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 205918016575 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 205918016576 Trp docking motif [polypeptide binding]; other site 205918016577 putative active site [active] 205918016578 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016579 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016580 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016581 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016582 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016583 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 205918016584 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 205918016585 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918016586 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 205918016587 classical (c) SDRs; Region: SDR_c; cd05233 205918016588 NAD(P) binding site [chemical binding]; other site 205918016589 active site 205918016590 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 205918016591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918016592 NAD(P) binding site [chemical binding]; other site 205918016593 active site 205918016594 1 probable transmembrane helix predicted by TMHMM2.0 205918016595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918016596 benzoate transport; Region: 2A0115; TIGR00895 205918016597 putative substrate translocation pore; other site 205918016598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918016599 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016600 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016601 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016602 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016603 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016604 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016605 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016606 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016607 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016608 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016609 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016610 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016611 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 205918016612 active site 205918016613 catalytic site [active] 205918016614 Zn binding site [ion binding]; other site 205918016615 tetramer interface [polypeptide binding]; other site 205918016616 hypothetical protein; Provisional; Region: PRK06102 205918016617 Amidase; Region: Amidase; cl11426 205918016618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918016619 DNA-binding site [nucleotide binding]; DNA binding site 205918016620 Transcriptional regulators [Transcription]; Region: FadR; COG2186 205918016621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918016622 DNA-binding site [nucleotide binding]; DNA binding site 205918016623 FCD domain; Region: FCD; cl11656 205918016624 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 205918016625 apolar tunnel; other site 205918016626 heme binding site [chemical binding]; other site 205918016627 dimerization interface [polypeptide binding]; other site 205918016628 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 205918016629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918016630 dimerization interface [polypeptide binding]; other site 205918016631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918016632 metal binding site [ion binding]; metal-binding site 205918016633 active site 205918016634 I-site; other site 205918016635 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918016636 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016637 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016638 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 205918016639 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 205918016640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918016641 Walker A motif; other site 205918016642 ATP binding site [chemical binding]; other site 205918016643 Walker B motif; other site 205918016644 arginine finger; other site 205918016645 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 205918016646 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 205918016647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918016648 S-adenosylmethionine binding site [chemical binding]; other site 205918016649 Methyltransferase domain; Region: Methyltransf_31; pfam13847 205918016650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918016651 S-adenosylmethionine binding site [chemical binding]; other site 205918016652 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 205918016653 active site 205918016654 hydrophilic channel; other site 205918016655 dimerization interface [polypeptide binding]; other site 205918016656 catalytic residues [active] 205918016657 active site lid [active] 205918016658 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 205918016659 Recombination protein O N terminal; Region: RecO_N; cl15812 205918016660 Recombination protein O C terminal; Region: RecO_C; pfam02565 205918016661 GTPase Era; Reviewed; Region: era; PRK00089 205918016662 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 205918016663 G1 box; other site 205918016664 GTP/Mg2+ binding site [chemical binding]; other site 205918016665 Switch I region; other site 205918016666 G2 box; other site 205918016667 Switch II region; other site 205918016668 G3 box; other site 205918016669 G4 box; other site 205918016670 G5 box; other site 205918016671 ribonuclease III; Reviewed; Region: rnc; PRK00102 205918016672 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 205918016673 dimerization interface [polypeptide binding]; other site 205918016674 active site 205918016675 metal binding site [ion binding]; metal-binding site 205918016676 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 205918016677 dsRNA binding site [nucleotide binding]; other site 205918016678 1 probable transmembrane helix predicted by TMHMM2.0 205918016679 signal peptidase I; Provisional; Region: PRK10861 205918016680 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 205918016681 Catalytic site [active] 205918016682 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 205918016683 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016684 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016685 GTP-binding protein LepA; Provisional; Region: PRK05433 205918016686 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 205918016687 G1 box; other site 205918016688 putative GEF interaction site [polypeptide binding]; other site 205918016689 GTP/Mg2+ binding site [chemical binding]; other site 205918016690 Switch I region; other site 205918016691 G2 box; other site 205918016692 G3 box; other site 205918016693 Switch II region; other site 205918016694 G4 box; other site 205918016695 G5 box; other site 205918016696 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 205918016697 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 205918016698 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 205918016699 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 205918016700 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 205918016701 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 205918016702 protein binding site [polypeptide binding]; other site 205918016703 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 205918016704 protein binding site [polypeptide binding]; other site 205918016705 MucB/RseB family; Region: MucB_RseB; pfam03888 205918016706 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 205918016707 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 205918016708 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 205918016709 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 205918016710 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 205918016711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918016712 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918016713 DNA binding residues [nucleotide binding] 205918016714 L-aspartate oxidase; Provisional; Region: PRK09077 205918016715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918016716 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 205918016717 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016718 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016719 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 205918016720 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 205918016721 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 205918016722 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 205918016723 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 205918016724 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918016725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918016726 dimer interface [polypeptide binding]; other site 205918016727 phosphorylation site [posttranslational modification] 205918016728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918016729 ATP binding site [chemical binding]; other site 205918016730 Mg2+ binding site [ion binding]; other site 205918016731 G-X-G motif; other site 205918016732 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016733 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016734 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 205918016735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918016736 active site 205918016737 phosphorylation site [posttranslational modification] 205918016738 intermolecular recognition site; other site 205918016739 dimerization interface [polypeptide binding]; other site 205918016740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918016741 DNA binding site [nucleotide binding] 205918016742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 205918016743 NMT1-like family; Region: NMT1_2; cl15260 205918016744 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 205918016745 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016746 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016747 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016748 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016749 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 205918016750 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016751 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016752 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016753 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016754 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016755 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016756 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016757 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016758 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016759 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016760 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016761 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016762 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 205918016763 Putative ammonia monooxygenase; Region: AmoA; pfam05145 205918016764 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 205918016765 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016766 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016767 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016768 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016769 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016770 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016771 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918016772 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 205918016773 ligand binding site [chemical binding]; other site 205918016774 active site 205918016775 UGI interface [polypeptide binding]; other site 205918016776 catalytic site [active] 205918016777 NMT1-like family; Region: NMT1_2; cl15260 205918016778 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918016779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 205918016780 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016781 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016782 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016783 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016784 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918016785 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 205918016786 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 205918016787 Walker A/P-loop; other site 205918016788 ATP binding site [chemical binding]; other site 205918016789 Q-loop/lid; other site 205918016790 ABC transporter signature motif; other site 205918016791 Walker B; other site 205918016792 D-loop; other site 205918016793 H-loop/switch region; other site 205918016794 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 205918016795 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 205918016796 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 205918016797 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 205918016798 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 205918016799 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918016800 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918016801 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 205918016802 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 205918016803 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 205918016804 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 205918016805 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 205918016806 carboxyltransferase (CT) interaction site; other site 205918016807 biotinylation site [posttranslational modification]; other site 205918016808 allophanate hydrolase; Provisional; Region: PRK08186 205918016809 Amidase; Region: Amidase; cl11426 205918016810 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 205918016811 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 205918016812 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205918016813 RNA binding surface [nucleotide binding]; other site 205918016814 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 205918016815 active site 205918016816 uracil binding [chemical binding]; other site 205918016817 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918016818 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 205918016819 active site 205918016820 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 205918016821 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 205918016822 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 205918016823 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918016824 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 205918016825 Family description; Region: UvrD_C_2; cl15862 205918016826 Pectate lyase; Region: Pec_lyase_C; cl01593 205918016827 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918016828 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918016829 putative alcohol dehydrogenase; Provisional; Region: PRK09860 205918016830 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 205918016831 dimer interface [polypeptide binding]; other site 205918016832 active site 205918016833 metal binding site [ion binding]; metal-binding site 205918016834 Methyltransferase domain; Region: Methyltransf_31; pfam13847 205918016835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918016836 S-adenosylmethionine binding site [chemical binding]; other site 205918016837 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205918016838 Repair protein; Region: Repair_PSII; cl01535 205918016839 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016840 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918016841 Repair protein; Region: Repair_PSII; cl01535 205918016842 1 probable transmembrane helix predicted by TMHMM2.0 205918016843 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 205918016844 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 205918016845 Fibronectin type III-like domain; Region: Fn3-like; cl15273 205918016846 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 205918016847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918016848 dimer interface [polypeptide binding]; other site 205918016849 phosphorylation site [posttranslational modification] 205918016850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918016851 ATP binding site [chemical binding]; other site 205918016852 Mg2+ binding site [ion binding]; other site 205918016853 G-X-G motif; other site 205918016854 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918016855 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918016856 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918016857 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918016858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918016859 active site 205918016860 phosphorylation site [posttranslational modification] 205918016861 intermolecular recognition site; other site 205918016862 dimerization interface [polypeptide binding]; other site 205918016863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918016864 Walker A motif; other site 205918016865 ATP binding site [chemical binding]; other site 205918016866 Walker B motif; other site 205918016867 arginine finger; other site 205918016868 Helix-turn-helix domains; Region: HTH; cl00088 205918016869 PAS fold; Region: PAS_4; pfam08448 205918016870 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 205918016871 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918016872 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 205918016873 putative active site [active] 205918016874 heme pocket [chemical binding]; other site 205918016875 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918016876 dimer interface [polypeptide binding]; other site 205918016877 phosphorylation site [posttranslational modification] 205918016878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918016879 ATP binding site [chemical binding]; other site 205918016880 Mg2+ binding site [ion binding]; other site 205918016881 G-X-G motif; other site 205918016882 Response regulator receiver domain; Region: Response_reg; pfam00072 205918016883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918016884 active site 205918016885 phosphorylation site [posttranslational modification] 205918016886 intermolecular recognition site; other site 205918016887 dimerization interface [polypeptide binding]; other site 205918016888 Hsp70 protein; Region: HSP70; pfam00012 205918016889 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 205918016890 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918016891 HSP70 interaction site [polypeptide binding]; other site 205918016892 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016893 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016894 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016895 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918016896 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 205918016897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918016898 putative substrate translocation pore; other site 205918016899 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016900 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016901 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016902 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016903 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016904 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016905 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016906 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016907 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016908 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016909 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016910 1 probable transmembrane helix predicted by TMHMM2.0 205918016911 Flavin Reductases; Region: FlaRed; cl00801 205918016912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918016913 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918016914 putative substrate translocation pore; other site 205918016915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918016916 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918016917 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918016918 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918016919 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918016920 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918016921 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918016922 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918016923 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918016924 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918016925 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918016926 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918016927 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918016928 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918016929 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 205918016930 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 205918016931 Helix-turn-helix domains; Region: HTH; cl00088 205918016932 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 205918016933 1 probable transmembrane helix predicted by TMHMM2.0 205918016934 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 205918016935 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918016936 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918016937 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 205918016938 Protein export membrane protein; Region: SecD_SecF; cl14618 205918016939 Protein export membrane protein; Region: SecD_SecF; cl14618 205918016940 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016941 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016942 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016943 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016944 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016945 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016946 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016947 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016948 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016949 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016950 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918016951 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 205918016952 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 205918016953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918016954 putative substrate translocation pore; other site 205918016955 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016956 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016957 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016958 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016959 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016960 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016961 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016962 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016963 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016964 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016965 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016966 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918016967 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 205918016968 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 205918016969 dimer interface [polypeptide binding]; other site 205918016970 active site 205918016971 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 205918016972 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 205918016973 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 205918016974 Helix-turn-helix domains; Region: HTH; cl00088 205918016975 Bacterial transcriptional regulator; Region: IclR; pfam01614 205918016976 Phosphate transporter family; Region: PHO4; cl00396 205918016977 Phosphate transporter family; Region: PHO4; cl00396 205918016978 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016979 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016980 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016981 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016982 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016983 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016984 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016985 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016986 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016987 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918016988 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 205918016989 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 205918016990 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 205918016991 putative active site [active] 205918016992 putative substrate binding site [chemical binding]; other site 205918016993 putative cosubstrate binding site; other site 205918016994 catalytic site [active] 205918016995 exonuclease I; Provisional; Region: sbcB; PRK11779 205918016996 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 205918016997 active site 205918016998 catalytic site [active] 205918016999 substrate binding site [chemical binding]; other site 205918017000 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 205918017001 RDD family; Region: RDD; cl00746 205918017002 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017003 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017004 Integral membrane protein DUF95; Region: DUF95; cl00572 205918017005 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017006 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017007 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017008 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017009 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017010 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017011 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017012 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017013 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017014 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017015 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017016 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 205918017017 1 probable transmembrane helix predicted by TMHMM2.0 205918017018 MoxR-like ATPases [General function prediction only]; Region: COG0714 205918017019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918017020 Walker A motif; other site 205918017021 ATP binding site [chemical binding]; other site 205918017022 Walker B motif; other site 205918017023 arginine finger; other site 205918017024 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 205918017025 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 205918017026 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 205918017027 PilZ domain; Region: PilZ; cl01260 205918017028 pyruvate kinase; Provisional; Region: PRK05826 205918017029 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 205918017030 domain interfaces; other site 205918017031 active site 205918017032 hypothetical protein; Provisional; Region: PRK05713 205918017033 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205918017034 catalytic loop [active] 205918017035 iron binding site [ion binding]; other site 205918017036 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 205918017037 FAD binding pocket [chemical binding]; other site 205918017038 conserved FAD binding motif [chemical binding]; other site 205918017039 phosphate binding motif [ion binding]; other site 205918017040 beta-alpha-beta structure motif; other site 205918017041 NAD binding pocket [chemical binding]; other site 205918017042 putative fumarate hydratase; Provisional; Region: PRK15392 205918017043 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 205918017044 Fumarase C-terminus; Region: Fumerase_C; cl00795 205918017045 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918017046 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918017047 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918017048 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918017049 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; cl04143 205918017050 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 205918017051 Family description; Region: VCBS; pfam13517 205918017052 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 205918017053 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 205918017054 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918017055 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918017056 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918017057 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918017058 Protein of unknown function (DUF796); Region: DUF796; cl01226 205918017059 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 205918017060 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 205918017061 putative active site [active] 205918017062 catalytic site [active] 205918017063 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 205918017064 PLD-like domain; Region: PLDc_2; pfam13091 205918017065 putative active site [active] 205918017066 catalytic site [active] 205918017067 YceI-like domain; Region: YceI; cl01001 205918017068 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017069 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017070 1 probable transmembrane helix predicted by TMHMM2.0 205918017071 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 205918017072 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918017073 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918017074 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 205918017075 putative acyl-acceptor binding pocket; other site 205918017076 1 probable transmembrane helix predicted by TMHMM2.0 205918017077 Protein of unknown function, DUF479; Region: DUF479; cl01203 205918017078 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918017079 dimerization interface [polypeptide binding]; other site 205918017080 putative DNA binding site [nucleotide binding]; other site 205918017081 putative Zn2+ binding site [ion binding]; other site 205918017082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918017083 putative substrate translocation pore; other site 205918017084 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918017085 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017086 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017087 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017088 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017089 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017090 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017091 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017092 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017093 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017094 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017095 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017096 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918017097 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 205918017098 FMN binding site [chemical binding]; other site 205918017099 active site 205918017100 substrate binding site [chemical binding]; other site 205918017101 catalytic residue [active] 205918017102 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205918017103 1 probable transmembrane helix predicted by TMHMM2.0 205918017104 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205918017105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918017106 NAD(P) binding site [chemical binding]; other site 205918017107 active site 205918017108 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 205918017109 Helix-turn-helix domains; Region: HTH; cl00088 205918017110 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918017111 dimerization interface [polypeptide binding]; other site 205918017112 LysE type translocator; Region: LysE; cl00565 205918017113 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017114 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017115 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017116 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017117 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017118 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017119 superoxide dismutase; Provisional; Region: PRK10543 205918017120 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 205918017121 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 205918017122 biofilm formation regulator HmsP; Provisional; Region: PRK11829 205918017123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918017124 metal binding site [ion binding]; metal-binding site 205918017125 active site 205918017126 I-site; other site 205918017127 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918017128 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017129 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017130 Imelysin; Region: Peptidase_M75; cl09159 205918017131 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 205918017132 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 205918017133 Imelysin; Region: Peptidase_M75; cl09159 205918017134 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 205918017135 1 probable transmembrane helix predicted by TMHMM2.0 205918017136 1 probable transmembrane helix predicted by TMHMM2.0 205918017137 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918017138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918017139 S-adenosylmethionine binding site [chemical binding]; other site 205918017140 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 205918017141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918017142 dimer interface [polypeptide binding]; other site 205918017143 phosphorylation site [posttranslational modification] 205918017144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918017145 ATP binding site [chemical binding]; other site 205918017146 Mg2+ binding site [ion binding]; other site 205918017147 G-X-G motif; other site 205918017148 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017149 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205918017151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918017152 active site 205918017153 phosphorylation site [posttranslational modification] 205918017154 intermolecular recognition site; other site 205918017155 dimerization interface [polypeptide binding]; other site 205918017156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918017157 DNA binding site [nucleotide binding] 205918017158 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 205918017159 active site 205918017160 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017161 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017162 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017163 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017164 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017165 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017166 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 205918017167 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 205918017168 ring oligomerisation interface [polypeptide binding]; other site 205918017169 ATP/Mg binding site [chemical binding]; other site 205918017170 stacking interactions; other site 205918017171 hinge regions; other site 205918017172 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 205918017173 oligomerisation interface [polypeptide binding]; other site 205918017174 mobile loop; other site 205918017175 roof hairpin; other site 205918017176 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 205918017177 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017178 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017179 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017180 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 205918017181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918017182 NAD(P) binding site [chemical binding]; other site 205918017183 active site 205918017184 Protein of unknown function, DUF481; Region: DUF481; cl01213 205918017185 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 205918017186 DNA binding site [nucleotide binding] 205918017187 active site 205918017188 muropeptide transporter; Validated; Region: ampG; PRK11010 205918017189 muropeptide transporter; Validated; Region: ampG; PRK11010 205918017190 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017191 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017192 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017193 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017194 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017195 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017196 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017197 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017198 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017199 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017200 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017201 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017202 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017203 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918017204 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017205 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017206 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 205918017208 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 205918017209 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 205918017210 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 205918017211 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 205918017212 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 205918017213 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 205918017214 1 probable transmembrane helix predicted by TMHMM2.0 205918017215 PAAR motif; Region: PAAR_motif; cl15808 205918017216 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 205918017217 1 probable transmembrane helix predicted by TMHMM2.0 205918017218 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918017219 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017220 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017221 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918017222 Protein of unknown function (DUF520); Region: DUF520; cl00723 205918017223 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 205918017224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918017225 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 205918017226 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 205918017227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918017228 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918017229 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 205918017230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918017231 dimer interface [polypeptide binding]; other site 205918017232 phosphorylation site [posttranslational modification] 205918017233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918017234 ATP binding site [chemical binding]; other site 205918017235 Mg2+ binding site [ion binding]; other site 205918017236 G-X-G motif; other site 205918017237 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017238 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017239 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 205918017240 hypothetical protein; Provisional; Region: PRK08999 205918017241 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 205918017242 active site 205918017243 8-oxo-dGMP binding site [chemical binding]; other site 205918017244 nudix motif; other site 205918017245 metal binding site [ion binding]; metal-binding site 205918017246 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 205918017247 thiamine phosphate binding site [chemical binding]; other site 205918017248 active site 205918017249 pyrophosphate binding site [ion binding]; other site 205918017250 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 205918017251 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 205918017252 putative C-terminal domain interface [polypeptide binding]; other site 205918017253 putative GSH binding site (G-site) [chemical binding]; other site 205918017254 putative dimer interface [polypeptide binding]; other site 205918017255 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 205918017256 putative substrate binding pocket (H-site) [chemical binding]; other site 205918017257 putative N-terminal domain interface [polypeptide binding]; other site 205918017258 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 205918017259 heterotetramer interface [polypeptide binding]; other site 205918017260 active site pocket [active] 205918017261 cleavage site 205918017262 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 205918017263 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 205918017264 SEC-C motif; Region: SEC-C; pfam02810 205918017265 Protein of unknown function (DUF721); Region: DUF721; cl02324 205918017266 Protein of unknown function (DUF721); Region: DUF721; cl02324 205918017267 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 205918017268 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 205918017269 cell division protein FtsZ; Validated; Region: PRK09330 205918017270 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 205918017271 nucleotide binding site [chemical binding]; other site 205918017272 SulA interaction site; other site 205918017273 cell division protein FtsA; Region: ftsA; TIGR01174 205918017274 Cell division protein FtsA; Region: FtsA; cl11496 205918017275 Cell division protein FtsA; Region: FtsA; cl11496 205918017276 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 205918017277 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 205918017278 Cell division protein FtsQ; Region: FtsQ; pfam03799 205918017279 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 205918017280 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 205918017281 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918017282 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 205918017283 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 205918017284 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205918017285 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205918017286 1 probable transmembrane helix predicted by TMHMM2.0 205918017287 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 205918017288 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 205918017289 active site 205918017290 homodimer interface [polypeptide binding]; other site 205918017291 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 205918017292 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017293 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017294 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017295 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017296 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017297 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017298 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017299 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017300 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017301 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 205918017302 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205918017303 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205918017304 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 205918017305 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 205918017306 Mg++ binding site [ion binding]; other site 205918017307 putative catalytic motif [active] 205918017308 putative substrate binding site [chemical binding]; other site 205918017309 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017310 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017311 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017312 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017313 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017314 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017315 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017316 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017317 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017318 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918017319 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 205918017320 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 205918017321 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205918017322 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205918017323 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 205918017324 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 205918017325 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205918017326 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205918017327 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 205918017328 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 205918017329 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918017330 1 probable transmembrane helix predicted by TMHMM2.0 205918017331 Septum formation initiator; Region: DivIC; cl11433 205918017332 1 probable transmembrane helix predicted by TMHMM2.0 205918017333 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 205918017334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918017335 MraZ protein; Region: MraZ; pfam02381 205918017336 MraZ protein; Region: MraZ; pfam02381 205918017337 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 205918017338 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 205918017339 LppC putative lipoprotein; Region: LppC; pfam04348 205918017340 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 205918017341 putative ligand binding site [chemical binding]; other site 205918017342 Restriction endonuclease; Region: Mrr_cat; cl00516 205918017343 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 205918017344 dimer interface [polypeptide binding]; other site 205918017345 active site 205918017346 BON domain; Region: BON; cl02771 205918017347 BON domain; Region: BON; cl02771 205918017348 Stringent starvation protein B; Region: SspB; cl01120 205918017349 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 205918017350 stringent starvation protein A; Provisional; Region: sspA; PRK09481 205918017351 C-terminal domain interface [polypeptide binding]; other site 205918017352 putative GSH binding site (G-site) [chemical binding]; other site 205918017353 dimer interface [polypeptide binding]; other site 205918017354 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 205918017355 dimer interface [polypeptide binding]; other site 205918017356 N-terminal domain interface [polypeptide binding]; other site 205918017357 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 205918017358 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 205918017359 23S rRNA interface [nucleotide binding]; other site 205918017360 L3 interface [polypeptide binding]; other site 205918017361 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 205918017362 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 205918017363 conserved cys residue [active] 205918017364 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918017365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918017366 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 205918017367 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 205918017368 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 205918017369 active site 205918017370 HIGH motif; other site 205918017371 dimer interface [polypeptide binding]; other site 205918017372 KMSKS motif; other site 205918017373 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 205918017374 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 205918017375 1 probable transmembrane helix predicted by TMHMM2.0 205918017376 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 205918017377 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 205918017378 CysD dimerization site [polypeptide binding]; other site 205918017379 G1 box; other site 205918017380 putative GEF interaction site [polypeptide binding]; other site 205918017381 GTP/Mg2+ binding site [chemical binding]; other site 205918017382 Switch I region; other site 205918017383 G2 box; other site 205918017384 G3 box; other site 205918017385 Switch II region; other site 205918017386 G4 box; other site 205918017387 G5 box; other site 205918017388 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 205918017389 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 205918017390 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 205918017391 ligand-binding site [chemical binding]; other site 205918017392 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 205918017393 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 205918017394 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 205918017395 Active Sites [active] 205918017396 Uncharacterized conserved protein [Function unknown]; Region: COG0327 205918017397 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 205918017398 serine endoprotease; Provisional; Region: PRK10898 205918017399 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 205918017400 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 205918017401 protein binding site [polypeptide binding]; other site 205918017402 1 probable transmembrane helix predicted by TMHMM2.0 205918017403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 205918017404 Transposase; Region: DEDD_Tnp_IS110; pfam01548 205918017405 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 205918017406 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 205918017407 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918017408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918017409 homodimer interface [polypeptide binding]; other site 205918017410 catalytic residue [active] 205918017411 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 205918017412 histidinol dehydrogenase; Region: hisD; TIGR00069 205918017413 NAD binding site [chemical binding]; other site 205918017414 dimerization interface [polypeptide binding]; other site 205918017415 product binding site; other site 205918017416 substrate binding site [chemical binding]; other site 205918017417 zinc binding site [ion binding]; other site 205918017418 catalytic residues [active] 205918017419 ATP phosphoribosyltransferase; Region: HisG; cl15266 205918017420 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 205918017421 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 205918017422 hinge; other site 205918017423 active site 205918017424 BolA-like protein; Region: BolA; cl00386 205918017425 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 205918017426 anti sigma factor interaction site; other site 205918017427 regulatory phosphorylation site [posttranslational modification]; other site 205918017428 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 205918017429 mce related protein; Region: MCE; pfam02470 205918017430 1 probable transmembrane helix predicted by TMHMM2.0 205918017431 Permease; Region: Permease; cl00510 205918017432 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017433 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017434 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017435 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017436 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017437 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 205918017438 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 205918017439 Walker A/P-loop; other site 205918017440 ATP binding site [chemical binding]; other site 205918017441 Q-loop/lid; other site 205918017442 ABC transporter signature motif; other site 205918017443 Walker B; other site 205918017444 D-loop; other site 205918017445 H-loop/switch region; other site 205918017446 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 205918017447 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 205918017448 putative active site [active] 205918017449 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 205918017450 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 205918017451 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918017452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 205918017453 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 205918017454 1 probable transmembrane helix predicted by TMHMM2.0 205918017455 OstA-like protein; Region: OstA; cl00844 205918017456 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 205918017457 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 205918017458 Walker A/P-loop; other site 205918017459 ATP binding site [chemical binding]; other site 205918017460 Q-loop/lid; other site 205918017461 ABC transporter signature motif; other site 205918017462 Walker B; other site 205918017463 D-loop; other site 205918017464 H-loop/switch region; other site 205918017465 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 205918017466 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 205918017467 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 205918017468 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 205918017469 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 205918017470 30S subunit binding site; other site 205918017471 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 205918017472 active site 205918017473 phosphorylation site [posttranslational modification] 205918017474 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 205918017475 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 205918017476 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 205918017477 dimerization domain swap beta strand [polypeptide binding]; other site 205918017478 regulatory protein interface [polypeptide binding]; other site 205918017479 active site 205918017480 regulatory phosphorylation site [posttranslational modification]; other site 205918017481 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 205918017482 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 205918017483 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 205918017484 Ebola nucleoprotein; Region: Ebola_NP; pfam05505 205918017485 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 205918017486 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 205918017487 Protein of unknown function (DUF615); Region: DUF615; cl01147 205918017488 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 205918017489 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 205918017490 Predicted amidohydrolase [General function prediction only]; Region: COG0388 205918017491 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 205918017492 putative active site [active] 205918017493 catalytic triad [active] 205918017494 dimer interface [polypeptide binding]; other site 205918017495 TIGR02099 family protein; Region: TIGR02099 205918017496 AsmA-like C-terminal region; Region: AsmA_2; cl15864 205918017497 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017498 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017499 ribonuclease G; Provisional; Region: PRK11712 205918017500 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 205918017501 homodimer interface [polypeptide binding]; other site 205918017502 oligonucleotide binding site [chemical binding]; other site 205918017503 Maf-like protein; Region: Maf; pfam02545 205918017504 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 205918017505 active site 205918017506 dimer interface [polypeptide binding]; other site 205918017507 rod shape-determining protein MreD; Region: MreD; cl01087 205918017508 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017509 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017510 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017511 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017512 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017513 rod shape-determining protein MreC; Region: MreC; pfam04085 205918017514 rod shape-determining protein MreB; Provisional; Region: PRK13927 205918017515 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 205918017516 ATP binding site [chemical binding]; other site 205918017517 profilin binding site; other site 205918017518 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 205918017519 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 205918017520 Amidase; Region: Amidase; cl11426 205918017521 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 205918017522 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 205918017523 GatB domain; Region: GatB_Yqey; cl11497 205918017524 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 205918017525 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 205918017526 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 205918017527 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 205918017528 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017529 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017530 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017531 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017532 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017533 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017534 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017535 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017536 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017537 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017538 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017539 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 205918017540 Membrane transport protein; Region: Mem_trans; cl09117 205918017541 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017542 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017543 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017544 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017545 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017546 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017547 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017548 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017549 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918017550 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 205918017551 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 205918017552 putative active site [active] 205918017553 putative metal binding site [ion binding]; other site 205918017554 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205918017555 1 probable transmembrane helix predicted by TMHMM2.0 205918017556 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 205918017557 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 205918017558 putative RNA binding site [nucleotide binding]; other site 205918017559 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 205918017560 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 205918017561 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 205918017562 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 205918017563 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 205918017564 ligand binding site [chemical binding]; other site 205918017565 1 probable transmembrane helix predicted by TMHMM2.0 205918017566 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 205918017567 1 probable transmembrane helix predicted by TMHMM2.0 205918017568 BON domain; Region: BON; cl02771 205918017569 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 205918017570 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 205918017571 RNase E interface [polypeptide binding]; other site 205918017572 trimer interface [polypeptide binding]; other site 205918017573 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 205918017574 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 205918017575 RNase E interface [polypeptide binding]; other site 205918017576 trimer interface [polypeptide binding]; other site 205918017577 active site 205918017578 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 205918017579 putative nucleic acid binding region [nucleotide binding]; other site 205918017580 G-X-X-G motif; other site 205918017581 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 205918017582 RNA binding site [nucleotide binding]; other site 205918017583 domain interface; other site 205918017584 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 205918017585 16S/18S rRNA binding site [nucleotide binding]; other site 205918017586 S13e-L30e interaction site [polypeptide binding]; other site 205918017587 25S rRNA binding site [nucleotide binding]; other site 205918017588 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 205918017589 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 205918017590 RNA binding site [nucleotide binding]; other site 205918017591 active site 205918017592 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 205918017593 Ribosome-binding factor A; Region: RBFA; cl00542 205918017594 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 205918017595 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 205918017596 translation initiation factor IF-2; Region: IF-2; TIGR00487 205918017597 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 205918017598 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 205918017599 G1 box; other site 205918017600 putative GEF interaction site [polypeptide binding]; other site 205918017601 GTP/Mg2+ binding site [chemical binding]; other site 205918017602 Switch I region; other site 205918017603 G2 box; other site 205918017604 G3 box; other site 205918017605 Switch II region; other site 205918017606 G4 box; other site 205918017607 G5 box; other site 205918017608 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 205918017609 Translation-initiation factor 2; Region: IF-2; pfam11987 205918017610 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 205918017611 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 205918017612 NusA N-terminal domain; Region: NusA_N; pfam08529 205918017613 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 205918017614 RNA binding site [nucleotide binding]; other site 205918017615 homodimer interface [polypeptide binding]; other site 205918017616 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 205918017617 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 205918017618 G-X-X-G motif; other site 205918017619 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 205918017620 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 205918017621 ribosome maturation protein RimP; Reviewed; Region: PRK00092 205918017622 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 205918017623 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 205918017624 Sm1 motif; other site 205918017625 D1 - D2 interaction site; other site 205918017626 D3 - B interaction site; other site 205918017627 Hfq - Hfq interaction site; other site 205918017628 RNA binding pocket [nucleotide binding]; other site 205918017629 Sm2 motif; other site 205918017630 Preprotein translocase SecG subunit; Region: SecG; cl09123 205918017631 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017632 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017633 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 205918017634 substrate binding site [chemical binding]; other site 205918017635 dimer interface [polypeptide binding]; other site 205918017636 catalytic triad [active] 205918017637 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 205918017638 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 205918017639 active site 205918017640 substrate binding site [chemical binding]; other site 205918017641 metal binding site [ion binding]; metal-binding site 205918017642 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 205918017643 dihydropteroate synthase; Region: DHPS; TIGR01496 205918017644 substrate binding pocket [chemical binding]; other site 205918017645 dimer interface [polypeptide binding]; other site 205918017646 inhibitor binding site; inhibition site 205918017647 FtsH Extracellular; Region: FtsH_ext; pfam06480 205918017648 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 205918017649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918017650 Walker A motif; other site 205918017651 ATP binding site [chemical binding]; other site 205918017652 Walker B motif; other site 205918017653 arginine finger; other site 205918017654 Peptidase family M41; Region: Peptidase_M41; pfam01434 205918017655 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017656 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918017658 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 205918017659 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 205918017660 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 205918017661 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 205918017662 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 205918017663 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 205918017664 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918017665 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918017666 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 205918017667 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918017668 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918017669 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 205918017670 IMP binding site; other site 205918017671 dimer interface [polypeptide binding]; other site 205918017672 interdomain contacts; other site 205918017673 partial ornithine binding site; other site 205918017674 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 205918017675 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 205918017676 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 205918017677 catalytic site [active] 205918017678 subunit interface [polypeptide binding]; other site 205918017679 dihydrodipicolinate reductase; Provisional; Region: PRK00048 205918017680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918017681 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 205918017682 chaperone protein DnaJ; Provisional; Region: PRK10767 205918017683 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918017684 HSP70 interaction site [polypeptide binding]; other site 205918017685 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 205918017686 substrate binding site [polypeptide binding]; other site 205918017687 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 205918017688 Zn binding sites [ion binding]; other site 205918017689 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 205918017690 dimer interface [polypeptide binding]; other site 205918017691 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 205918017692 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 205918017693 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 205918017694 dimer interface [polypeptide binding]; other site 205918017695 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 205918017696 recombination and repair protein; Provisional; Region: PRK10869 205918017697 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 205918017698 Walker A/P-loop; other site 205918017699 ATP binding site [chemical binding]; other site 205918017700 Q-loop/lid; other site 205918017701 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 205918017702 ABC transporter signature motif; other site 205918017703 Walker B; other site 205918017704 D-loop; other site 205918017705 H-loop/switch region; other site 205918017706 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 205918017707 metal binding site 2 [ion binding]; metal-binding site 205918017708 putative DNA binding helix; other site 205918017709 metal binding site 1 [ion binding]; metal-binding site 205918017710 dimer interface [polypeptide binding]; other site 205918017711 structural Zn2+ binding site [ion binding]; other site 205918017712 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 205918017713 1 probable transmembrane helix predicted by TMHMM2.0 205918017714 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 205918017715 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 205918017716 putative coenzyme Q binding site [chemical binding]; other site 205918017717 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 205918017718 Na2 binding site [ion binding]; other site 205918017719 putative substrate binding site 1 [chemical binding]; other site 205918017720 Na binding site 1 [ion binding]; other site 205918017721 putative substrate binding site 2 [chemical binding]; other site 205918017722 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017723 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017724 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017725 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017726 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017727 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017728 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017729 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017730 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017731 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017732 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017733 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 205918017734 SmpB-tmRNA interface; other site 205918017735 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; cl04143 205918017736 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918017737 metal binding site [ion binding]; metal-binding site 205918017738 active site 205918017739 I-site; other site 205918017740 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017741 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017742 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017743 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017744 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017745 putative acetyltransferase; Provisional; Region: PRK03624 205918017746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918017747 Coenzyme A binding pocket [chemical binding]; other site 205918017748 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 205918017749 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 205918017750 dimer interface [polypeptide binding]; other site 205918017751 active site 205918017752 heme binding site [chemical binding]; other site 205918017753 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 205918017754 PAS fold; Region: PAS_3; pfam08447 205918017755 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 205918017756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918017757 PAS fold; Region: PAS_3; pfam08447 205918017758 putative active site [active] 205918017759 heme pocket [chemical binding]; other site 205918017760 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918017761 putative CheW interface [polypeptide binding]; other site 205918017762 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 205918017763 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017764 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017765 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017766 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017767 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017768 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017769 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017770 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017771 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017772 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017773 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017774 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 205918017775 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205918017776 1 probable transmembrane helix predicted by TMHMM2.0 205918017777 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 205918017778 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918017779 Walker A/P-loop; other site 205918017780 ATP binding site [chemical binding]; other site 205918017781 Q-loop/lid; other site 205918017782 ABC transporter signature motif; other site 205918017783 Walker B; other site 205918017784 D-loop; other site 205918017785 H-loop/switch region; other site 205918017786 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918017787 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 205918017788 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918017789 Walker A/P-loop; other site 205918017790 ATP binding site [chemical binding]; other site 205918017791 Q-loop/lid; other site 205918017792 ABC transporter signature motif; other site 205918017793 Walker B; other site 205918017794 D-loop; other site 205918017795 H-loop/switch region; other site 205918017796 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918017797 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 205918017798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918017799 dimer interface [polypeptide binding]; other site 205918017800 conserved gate region; other site 205918017801 putative PBP binding loops; other site 205918017802 ABC-ATPase subunit interface; other site 205918017803 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017804 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017805 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017806 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017807 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017808 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017809 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205918017810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918017811 dimer interface [polypeptide binding]; other site 205918017812 conserved gate region; other site 205918017813 putative PBP binding loops; other site 205918017814 ABC-ATPase subunit interface; other site 205918017815 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017816 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017817 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017818 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017819 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017820 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017821 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 205918017822 Autoinducer binding domain; Region: Autoind_bind; pfam03472 205918017823 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918017824 DNA binding residues [nucleotide binding] 205918017825 dimerization interface [polypeptide binding]; other site 205918017826 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 205918017827 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918017828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918017829 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918017830 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918017831 dimer interface [polypeptide binding]; other site 205918017832 putative CheW interface [polypeptide binding]; other site 205918017833 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017834 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017835 GAF domain; Region: GAF; cl15785 205918017836 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918017837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918017838 Coenzyme A binding pocket [chemical binding]; other site 205918017839 GAF domain; Region: GAF_2; pfam13185 205918017840 GAF domain; Region: GAF; cl15785 205918017841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918017842 metal binding site [ion binding]; metal-binding site 205918017843 active site 205918017844 I-site; other site 205918017845 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918017846 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 205918017847 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017848 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017849 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017850 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017851 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017852 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017853 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918017854 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017855 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918017856 galactarate dehydratase; Region: galactar-dH20; TIGR03248 205918017857 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 205918017858 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 205918017859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918017860 D-galactonate transporter; Region: 2A0114; TIGR00893 205918017861 putative substrate translocation pore; other site 205918017862 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017863 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017864 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017865 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017866 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017867 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017868 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017869 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017870 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017871 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017872 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918017873 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 205918017874 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 205918017875 putative active site [active] 205918017876 catalytic residue [active] 205918017877 Transcriptional regulators [Transcription]; Region: FadR; COG2186 205918017878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918017879 DNA-binding site [nucleotide binding]; DNA binding site 205918017880 FCD domain; Region: FCD; cl11656 205918017881 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205918017882 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 205918017883 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 205918017884 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017885 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017886 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017887 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017888 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017889 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 205918017890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918017891 active site 205918017892 phosphorylation site [posttranslational modification] 205918017893 intermolecular recognition site; other site 205918017894 dimerization interface [polypeptide binding]; other site 205918017895 Helix-turn-helix domains; Region: HTH; cl00088 205918017896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 205918017897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 205918017898 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017899 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017900 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017901 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017902 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918017903 Protein of unknown function (DUF541); Region: SIMPL; cl01077 205918017904 Heterokaryon incompatibility protein Het-C; Region: Het-C; pfam07217 205918017905 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 205918017906 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205918017907 peptide binding site [polypeptide binding]; other site 205918017908 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 205918017909 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205918017910 peptide binding site [polypeptide binding]; other site 205918017911 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 205918017912 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205918017913 peptide binding site [polypeptide binding]; other site 205918017914 outer membrane porin, OprD family; Region: OprD; pfam03573 205918017915 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 205918017916 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205918017917 peptide binding site [polypeptide binding]; other site 205918017918 dipeptide transporter permease DppB; Provisional; Region: PRK10914 205918017919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918017920 dimer interface [polypeptide binding]; other site 205918017921 conserved gate region; other site 205918017922 putative PBP binding loops; other site 205918017923 ABC-ATPase subunit interface; other site 205918017924 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017925 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017926 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017927 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017928 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017929 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017930 dipeptide transporter; Provisional; Region: PRK10913 205918017931 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 205918017932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918017933 putative PBP binding loops; other site 205918017934 dimer interface [polypeptide binding]; other site 205918017935 ABC-ATPase subunit interface; other site 205918017936 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017937 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017938 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017939 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017940 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017941 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918017942 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 205918017943 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918017944 Walker A/P-loop; other site 205918017945 ATP binding site [chemical binding]; other site 205918017946 Q-loop/lid; other site 205918017947 ABC transporter signature motif; other site 205918017948 Walker B; other site 205918017949 D-loop; other site 205918017950 H-loop/switch region; other site 205918017951 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918017952 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 205918017953 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205918017954 Walker A/P-loop; other site 205918017955 ATP binding site [chemical binding]; other site 205918017956 Q-loop/lid; other site 205918017957 ABC transporter signature motif; other site 205918017958 Walker B; other site 205918017959 D-loop; other site 205918017960 H-loop/switch region; other site 205918017961 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205918017962 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 205918017963 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 205918017964 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 205918017965 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 205918017966 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 205918017967 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 205918017968 FAD binding pocket [chemical binding]; other site 205918017969 FAD binding motif [chemical binding]; other site 205918017970 catalytic residues [active] 205918017971 NAD binding pocket [chemical binding]; other site 205918017972 phosphate binding motif [ion binding]; other site 205918017973 beta-alpha-beta structure motif; other site 205918017974 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017975 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017976 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017977 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918017978 transferase, transferring glycosyl groups; Region: PLN02939 205918017979 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 205918017980 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 205918017981 dimer interface [polypeptide binding]; other site 205918017982 active site 205918017983 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918017984 catalytic residues [active] 205918017985 substrate binding site [chemical binding]; other site 205918017986 Peptidase M60-like family; Region: M60-like; pfam13402 205918017987 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 205918017988 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 205918017989 Walker A/P-loop; other site 205918017990 ATP binding site [chemical binding]; other site 205918017991 Q-loop/lid; other site 205918017992 ABC transporter signature motif; other site 205918017993 Walker B; other site 205918017994 D-loop; other site 205918017995 H-loop/switch region; other site 205918017996 FOG: CBS domain [General function prediction only]; Region: COG0517 205918017997 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 205918017998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918017999 dimer interface [polypeptide binding]; other site 205918018000 conserved gate region; other site 205918018001 ABC-ATPase subunit interface; other site 205918018002 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018003 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018004 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018005 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018006 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018007 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018008 NMT1-like family; Region: NMT1_2; cl15260 205918018009 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 205918018010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918018011 ABC-ATPase subunit interface; other site 205918018012 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018013 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018014 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018015 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018016 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018017 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 205918018018 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 205918018019 G1 box; other site 205918018020 putative GEF interaction site [polypeptide binding]; other site 205918018021 GTP/Mg2+ binding site [chemical binding]; other site 205918018022 Switch I region; other site 205918018023 G2 box; other site 205918018024 G3 box; other site 205918018025 Switch II region; other site 205918018026 G4 box; other site 205918018027 G5 box; other site 205918018028 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 205918018029 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 205918018030 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 205918018031 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 205918018032 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 205918018033 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918018034 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918018035 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918018036 AAA domain; Region: AAA_32; pfam13654 205918018037 ATP-dependent protease Lon; Provisional; Region: PRK13765 205918018038 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 205918018039 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 205918018040 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 205918018041 transcription elongation factor regulatory protein; Validated; Region: PRK06342 205918018042 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 205918018043 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 205918018044 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 205918018045 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 205918018046 ABC transporter; Region: ABC_tran_2; pfam12848 205918018047 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 205918018048 fumarate hydratase FumB; Provisional; Region: PRK15391 205918018049 PAS domain S-box; Region: sensory_box; TIGR00229 205918018050 PAS domain S-box; Region: sensory_box; TIGR00229 205918018051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918018052 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 205918018053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918018054 PAS domain; Region: PAS_9; pfam13426 205918018055 putative active site [active] 205918018056 heme pocket [chemical binding]; other site 205918018057 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918018058 metal binding site [ion binding]; metal-binding site 205918018059 active site 205918018060 I-site; other site 205918018061 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918018062 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018063 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918018065 dimerization interface [polypeptide binding]; other site 205918018066 DNA binding residues [nucleotide binding] 205918018067 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 205918018068 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 205918018069 Amidase; Region: Amidase; cl11426 205918018070 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 205918018071 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 205918018072 dimer interface [polypeptide binding]; other site 205918018073 active site 205918018074 glycine-pyridoxal phosphate binding site [chemical binding]; other site 205918018075 folate binding site [chemical binding]; other site 205918018076 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 205918018077 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 205918018078 P-loop, Walker A motif; other site 205918018079 Base recognition motif; other site 205918018080 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 205918018081 Protein of unknown function (DUF466); Region: DUF466; cl01082 205918018082 carbon starvation protein A; Provisional; Region: PRK15015 205918018083 Carbon starvation protein CstA; Region: CstA; pfam02554 205918018084 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 205918018085 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018086 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018087 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018088 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018089 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018090 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018091 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018092 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018093 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018094 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018095 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018096 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018097 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018098 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018099 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018100 1 of 16 probable transmembrane helices predicted by TMHMM2.0 205918018101 PilZ domain; Region: PilZ; cl01260 205918018102 DNA repair protein RadA; Provisional; Region: PRK11823 205918018103 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 205918018104 Walker A motif/ATP binding site; other site 205918018105 ATP binding site [chemical binding]; other site 205918018106 Walker B motif; other site 205918018107 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 205918018108 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 205918018109 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 205918018110 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018111 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018112 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 205918018113 ferredoxin-NADP reductase; Provisional; Region: PRK10926 205918018114 FAD binding pocket [chemical binding]; other site 205918018115 FAD binding motif [chemical binding]; other site 205918018116 phosphate binding motif [ion binding]; other site 205918018117 beta-alpha-beta structure motif; other site 205918018118 NAD binding pocket [chemical binding]; other site 205918018119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918018120 DNA binding residues [nucleotide binding] 205918018121 dimerization interface [polypeptide binding]; other site 205918018122 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 205918018123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918018124 S-adenosylmethionine binding site [chemical binding]; other site 205918018125 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 205918018126 1 probable transmembrane helix predicted by TMHMM2.0 205918018127 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 205918018128 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 205918018129 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 205918018130 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018131 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018132 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018133 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018134 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018135 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018136 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018137 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018138 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 205918018139 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018140 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018141 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018142 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018143 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018144 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018145 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018146 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018147 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018148 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 205918018149 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 205918018150 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 205918018151 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 205918018152 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 205918018153 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 205918018154 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 205918018155 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 205918018156 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018157 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018158 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018159 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018160 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018161 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018162 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018163 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018164 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018165 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018166 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018167 tRNA (uracil-5-)-methyltransferase; Region: trmA_only; TIGR02143 205918018168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918018169 S-adenosylmethionine binding site [chemical binding]; other site 205918018170 enterobactin exporter EntS; Provisional; Region: PRK10489 205918018171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918018172 putative substrate translocation pore; other site 205918018173 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018174 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018175 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018176 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018177 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018178 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018179 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018180 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018181 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018182 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 205918018183 1 probable transmembrane helix predicted by TMHMM2.0 205918018184 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 205918018185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918018186 active site 205918018187 motif I; other site 205918018188 motif II; other site 205918018189 acyl-CoA thioesterase II; Provisional; Region: PRK10526 205918018190 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 205918018191 active site 205918018192 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 205918018193 catalytic triad [active] 205918018194 dimer interface [polypeptide binding]; other site 205918018195 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205918018196 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918018197 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 205918018198 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 205918018199 HI0933-like protein; Region: HI0933_like; pfam03486 205918018200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918018201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918018202 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 205918018203 DEAD-like helicases superfamily; Region: DEXDc; smart00487 205918018204 ATP binding site [chemical binding]; other site 205918018205 Mg++ binding site [ion binding]; other site 205918018206 motif III; other site 205918018207 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918018208 nucleotide binding region [chemical binding]; other site 205918018209 ATP-binding site [chemical binding]; other site 205918018210 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 205918018211 EamA-like transporter family; Region: EamA; cl01037 205918018212 EamA-like transporter family; Region: EamA; cl01037 205918018213 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018214 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018215 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018216 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018217 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018218 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018219 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018220 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018221 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018222 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018223 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 205918018224 Helix-turn-helix domains; Region: HTH; cl00088 205918018225 AsnC family; Region: AsnC_trans_reg; pfam01037 205918018226 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 205918018227 active site 205918018228 catalytic site [active] 205918018229 substrate binding site [chemical binding]; other site 205918018230 LabA_like proteins; Region: LabA; cd10911 205918018231 putative metal binding site [ion binding]; other site 205918018232 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 205918018233 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 205918018234 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 205918018235 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018236 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018237 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018238 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018239 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018240 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018241 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 205918018242 putative catalytic site [active] 205918018243 putative metal binding site [ion binding]; other site 205918018244 putative phosphate binding site [ion binding]; other site 205918018245 1 probable transmembrane helix predicted by TMHMM2.0 205918018246 Leucine carboxyl methyltransferase; Region: LCM; cl01306 205918018247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 205918018248 AAA domain; Region: AAA_33; pfam13671 205918018249 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 205918018250 ATP-binding site [chemical binding]; other site 205918018251 Gluconate-6-phosphate binding site [chemical binding]; other site 205918018252 LysE type translocator; Region: LysE; cl00565 205918018253 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018254 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018255 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018256 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018257 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018258 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 205918018259 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 205918018260 active site 205918018261 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 205918018262 Acyl transferase domain; Region: Acyl_transf_1; cl08282 205918018263 Acyl transferase domain; Region: Acyl_transf_1; cl08282 205918018264 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 205918018265 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 205918018266 phosphate binding site [ion binding]; other site 205918018267 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 205918018268 putative NADP binding site [chemical binding]; other site 205918018269 active site 205918018270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918018271 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918018272 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918018273 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 205918018274 active site 205918018275 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918018276 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 205918018277 putative NADP binding site [chemical binding]; other site 205918018278 active site 205918018279 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918018280 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918018281 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 205918018282 active site 205918018283 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 205918018284 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918018285 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918018286 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 205918018287 active site 205918018288 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 205918018289 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918018290 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 205918018291 active site 205918018292 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 205918018293 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 205918018294 putative NADP binding site [chemical binding]; other site 205918018295 active site 205918018296 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918018297 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918018298 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 205918018299 active site 205918018300 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918018301 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 205918018302 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 205918018303 active site 205918018304 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 205918018305 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 205918018306 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 205918018307 active site 205918018308 dimer interface [polypeptide binding]; other site 205918018309 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 205918018310 Ligand Binding Site [chemical binding]; other site 205918018311 Molecular Tunnel; other site 205918018312 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918018313 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 205918018314 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 205918018315 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918018316 Helix-turn-helix domains; Region: HTH; cl00088 205918018317 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918018318 dimerization interface [polypeptide binding]; other site 205918018319 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 205918018320 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 205918018321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918018322 ATP binding site [chemical binding]; other site 205918018323 putative Mg++ binding site [ion binding]; other site 205918018324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918018325 nucleotide binding region [chemical binding]; other site 205918018326 ATP-binding site [chemical binding]; other site 205918018327 Helicase associated domain (HA2); Region: HA2; cl04503 205918018328 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 205918018329 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 205918018330 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 205918018331 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205918018332 catalytic residue [active] 205918018333 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918018334 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018335 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018336 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018337 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018338 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018339 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018340 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018341 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018342 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018343 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018344 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018345 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018346 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 205918018347 serine O-acetyltransferase; Region: cysE; TIGR01172 205918018348 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 205918018349 trimer interface [polypeptide binding]; other site 205918018350 active site 205918018351 substrate binding site [chemical binding]; other site 205918018352 CoA binding site [chemical binding]; other site 205918018353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918018354 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 205918018355 DNA-binding site [nucleotide binding]; DNA binding site 205918018356 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918018357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918018358 homodimer interface [polypeptide binding]; other site 205918018359 catalytic residue [active] 205918018360 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 205918018361 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918018362 HSP70 interaction site [polypeptide binding]; other site 205918018363 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 205918018364 homotrimer interaction site [polypeptide binding]; other site 205918018365 putative active site [active] 205918018366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918018367 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 205918018368 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918018369 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 205918018370 substrate binding pocket [chemical binding]; other site 205918018371 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918018372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918018373 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 205918018374 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018375 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018376 Cation efflux family; Region: Cation_efflux; cl00316 205918018377 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018378 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018379 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018380 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018381 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018382 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018383 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918018384 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918018385 putative DNA binding site [nucleotide binding]; other site 205918018386 putative Zn2+ binding site [ion binding]; other site 205918018387 AsnC family; Region: AsnC_trans_reg; pfam01037 205918018388 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 205918018389 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 205918018390 active site 205918018391 AMP nucleosidase; Provisional; Region: PRK08292 205918018392 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 205918018393 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 205918018394 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918018395 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918018396 active site 205918018397 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 205918018398 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 205918018399 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 205918018400 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918018401 dimer interface [polypeptide binding]; other site 205918018402 phosphorylation site [posttranslational modification] 205918018403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918018404 ATP binding site [chemical binding]; other site 205918018405 Mg2+ binding site [ion binding]; other site 205918018406 G-X-G motif; other site 205918018407 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018408 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018409 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018410 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018411 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018412 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018413 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018414 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 205918018415 dimer interface [polypeptide binding]; other site 205918018416 substrate binding site [chemical binding]; other site 205918018417 ATP binding site [chemical binding]; other site 205918018418 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 205918018419 thiamine phosphate binding site [chemical binding]; other site 205918018420 active site 205918018421 pyrophosphate binding site [ion binding]; other site 205918018422 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 205918018423 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918018424 inhibitor-cofactor binding pocket; inhibition site 205918018425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918018426 catalytic residue [active] 205918018427 Sel1 repeat; Region: Sel1; cl02723 205918018428 Sel1 repeat; Region: Sel1; cl02723 205918018429 1 probable transmembrane helix predicted by TMHMM2.0 205918018430 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 205918018431 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 205918018432 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 205918018433 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918018434 FeS/SAM binding site; other site 205918018435 TRAM domain; Region: TRAM; cl01282 205918018436 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 205918018437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918018438 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 205918018439 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 205918018440 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205918018441 Transporter associated domain; Region: CorC_HlyC; cl08393 205918018442 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 205918018443 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 205918018444 putative active site [active] 205918018445 catalytic triad [active] 205918018446 putative dimer interface [polypeptide binding]; other site 205918018447 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018448 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018449 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018450 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018451 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018452 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018453 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018454 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 205918018455 putative active site [active] 205918018456 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018457 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018458 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 205918018459 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 205918018460 HIGH motif; other site 205918018461 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 205918018462 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205918018463 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205918018464 active site 205918018465 KMSKS motif; other site 205918018466 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 205918018467 tRNA binding surface [nucleotide binding]; other site 205918018468 Lipopolysaccharide-assembly; Region: LptE; cl01125 205918018469 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 205918018470 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 205918018471 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018472 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018473 Domain of unknown function; Region: DUF331; cl01149 205918018474 Transglycosylase SLT domain; Region: SLT_2; pfam13406 205918018475 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 205918018476 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918018477 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 205918018478 lipoyl synthase; Provisional; Region: PRK05481 205918018479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918018480 FeS/SAM binding site; other site 205918018481 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 205918018482 Protein of unknown function (DUF493); Region: DUF493; cl01102 205918018483 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 205918018484 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918018485 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 205918018486 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 205918018487 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 205918018488 Sporulation related domain; Region: SPOR; cl10051 205918018489 Transglycosylase SLT domain; Region: SLT_2; pfam13406 205918018490 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 205918018491 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205918018492 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 205918018493 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018494 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018495 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018496 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018497 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018498 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018499 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018500 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018501 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018502 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018503 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 205918018504 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 205918018505 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918018506 1 probable transmembrane helix predicted by TMHMM2.0 205918018507 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 205918018508 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 205918018509 Oligomerisation domain; Region: Oligomerisation; cl00519 205918018510 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 205918018511 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 205918018512 active site 205918018513 (T/H)XGH motif; other site 205918018514 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 205918018515 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 205918018516 putative catalytic cysteine [active] 205918018517 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 205918018518 active site 205918018519 DNA binding site [nucleotide binding] 205918018520 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 205918018521 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 205918018522 active site 205918018523 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018524 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018525 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018526 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018527 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018528 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018529 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018530 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018531 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018532 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018533 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018534 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918018535 Predicted membrane protein [Function unknown]; Region: COG4655 205918018536 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 205918018537 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018538 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918018539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918018540 putative active site [active] 205918018541 heme pocket [chemical binding]; other site 205918018542 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918018543 PAS fold; Region: PAS_3; pfam08447 205918018544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918018545 PAS fold; Region: PAS_4; pfam08448 205918018546 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918018547 dimer interface [polypeptide binding]; other site 205918018548 phosphorylation site [posttranslational modification] 205918018549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918018550 ATP binding site [chemical binding]; other site 205918018551 Mg2+ binding site [ion binding]; other site 205918018552 G-X-G motif; other site 205918018553 1 probable transmembrane helix predicted by TMHMM2.0 205918018554 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018555 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018556 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018557 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018558 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918018559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918018560 active site 205918018561 phosphorylation site [posttranslational modification] 205918018562 intermolecular recognition site; other site 205918018563 dimerization interface [polypeptide binding]; other site 205918018564 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918018565 DNA binding residues [nucleotide binding] 205918018566 dimerization interface [polypeptide binding]; other site 205918018567 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 205918018568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 205918018569 active site 205918018570 phosphorylation site [posttranslational modification] 205918018571 intermolecular recognition site; other site 205918018572 dimerization interface [polypeptide binding]; other site 205918018573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918018574 active site 205918018575 phosphorylation site [posttranslational modification] 205918018576 intermolecular recognition site; other site 205918018577 dimerization interface [polypeptide binding]; other site 205918018578 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918018579 metal binding site [ion binding]; metal-binding site 205918018580 active site 205918018581 I-site; other site 205918018582 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 205918018583 1 probable transmembrane helix predicted by TMHMM2.0 205918018584 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 205918018585 nudix motif; other site 205918018586 translation initiation factor Sui1; Validated; Region: PRK06824 205918018587 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 205918018588 putative rRNA binding site [nucleotide binding]; other site 205918018589 arginine decarboxylase; Provisional; Region: PRK05354 205918018590 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 205918018591 dimer interface [polypeptide binding]; other site 205918018592 active site 205918018593 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205918018594 catalytic residues [active] 205918018595 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 205918018596 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 205918018597 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 205918018598 FecR protein; Region: FecR; pfam04773 205918018599 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918018600 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 205918018601 substrate binding pocket [chemical binding]; other site 205918018602 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 205918018603 MatE; Region: MatE; cl10513 205918018604 MatE; Region: MatE; cl10513 205918018605 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018606 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018607 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018608 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018609 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018610 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018611 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018612 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018613 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018614 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018615 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 205918018616 MG2 domain; Region: A2M_N; pfam01835 205918018617 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 205918018618 Alpha-2-macroglobulin family; Region: A2M; pfam00207 205918018619 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 205918018620 surface patch; other site 205918018621 thioester region; other site 205918018622 specificity defining residues; other site 205918018623 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918018624 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918018625 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918018626 penicillin-binding protein 1C; Provisional; Region: PRK11240 205918018627 Transglycosylase; Region: Transgly; cl07896 205918018628 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918018629 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 205918018630 1 probable transmembrane helix predicted by TMHMM2.0 205918018631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918018632 active site 205918018633 phosphorylation site [posttranslational modification] 205918018634 intermolecular recognition site; other site 205918018635 dimerization interface [polypeptide binding]; other site 205918018636 Flp/Fap pilin component; Region: Flp_Fap; cl01585 205918018637 1 probable transmembrane helix predicted by TMHMM2.0 205918018638 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 205918018639 1 probable transmembrane helix predicted by TMHMM2.0 205918018640 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 205918018641 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 205918018642 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 205918018643 1 probable transmembrane helix predicted by TMHMM2.0 205918018644 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 205918018645 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 205918018646 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 205918018647 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 205918018648 ATP binding site [chemical binding]; other site 205918018649 Walker A motif; other site 205918018650 hexamer interface [polypeptide binding]; other site 205918018651 Walker B motif; other site 205918018652 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 205918018653 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018654 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018655 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018656 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018657 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 205918018658 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 205918018659 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018660 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018661 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018662 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018663 TPR repeat; Region: TPR_11; pfam13414 205918018664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205918018665 binding surface 205918018666 TPR motif; other site 205918018667 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 205918018668 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 205918018669 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 205918018670 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 205918018671 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 205918018672 DsbD alpha interface [polypeptide binding]; other site 205918018673 catalytic residues [active] 205918018674 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018675 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018676 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018677 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018678 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018679 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018680 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018681 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018682 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 205918018683 trimer interface [polypeptide binding]; other site 205918018684 active site 205918018685 dimer interface [polypeptide binding]; other site 205918018686 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 205918018687 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 205918018688 carboxyltransferase (CT) interaction site; other site 205918018689 biotinylation site [posttranslational modification]; other site 205918018690 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 205918018691 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918018692 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918018693 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 205918018694 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 205918018695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918018696 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 205918018697 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 205918018698 1 probable transmembrane helix predicted by TMHMM2.0 205918018699 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 205918018700 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 205918018701 FMN binding site [chemical binding]; other site 205918018702 active site 205918018703 catalytic residues [active] 205918018704 substrate binding site [chemical binding]; other site 205918018705 Helix-turn-helix domains; Region: HTH; cl00088 205918018706 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 205918018707 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 205918018708 purine monophosphate binding site [chemical binding]; other site 205918018709 dimer interface [polypeptide binding]; other site 205918018710 putative catalytic residues [active] 205918018711 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 205918018712 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 205918018713 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 205918018714 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 205918018715 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918018716 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 205918018717 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 205918018718 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 205918018719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918018720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918018721 dimer interface [polypeptide binding]; other site 205918018722 phosphorylation site [posttranslational modification] 205918018723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918018724 ATP binding site [chemical binding]; other site 205918018725 Mg2+ binding site [ion binding]; other site 205918018726 G-X-G motif; other site 205918018727 Response regulator receiver domain; Region: Response_reg; pfam00072 205918018728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918018729 active site 205918018730 phosphorylation site [posttranslational modification] 205918018731 intermolecular recognition site; other site 205918018732 dimerization interface [polypeptide binding]; other site 205918018733 Response regulator receiver domain; Region: Response_reg; pfam00072 205918018734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918018735 active site 205918018736 phosphorylation site [posttranslational modification] 205918018737 intermolecular recognition site; other site 205918018738 dimerization interface [polypeptide binding]; other site 205918018739 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018740 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018741 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018742 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018743 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018744 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018745 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018746 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018747 MarC family integral membrane protein; Region: MarC; cl00919 205918018748 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018749 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018750 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018751 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018752 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018753 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918018754 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 205918018755 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 205918018756 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 205918018757 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 205918018758 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 205918018759 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 205918018760 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 205918018761 Precorrin-8X methylmutase; Region: CbiC; pfam02570 205918018762 precorrin-3B synthase; Region: CobG; TIGR02435 205918018763 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 205918018764 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 205918018765 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 205918018766 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 205918018767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918018768 CbiD; Region: CbiD; cl00828 205918018769 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 205918018770 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 205918018771 Transposase IS200 like; Region: Y1_Tnp; cl00848 205918018772 Protein of unknown function (DUF461); Region: DUF461; cl01071 205918018773 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 205918018774 1 probable transmembrane helix predicted by TMHMM2.0 205918018775 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 205918018776 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 205918018777 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 205918018778 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 205918018779 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018780 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018781 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018782 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018783 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918018784 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 205918018785 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 205918018786 putative ligand binding site [chemical binding]; other site 205918018787 HEAT repeats; Region: HEAT_2; pfam13646 205918018788 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 205918018789 TM-ABC transporter signature motif; other site 205918018790 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018791 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018792 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018793 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018794 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018795 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018796 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018797 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918018798 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 205918018799 TM-ABC transporter signature motif; other site 205918018800 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018801 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018802 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018803 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018804 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018805 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018806 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018807 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018808 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918018809 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 205918018810 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 205918018811 Walker A/P-loop; other site 205918018812 ATP binding site [chemical binding]; other site 205918018813 Q-loop/lid; other site 205918018814 ABC transporter signature motif; other site 205918018815 Walker B; other site 205918018816 D-loop; other site 205918018817 H-loop/switch region; other site 205918018818 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 205918018819 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 205918018820 Walker A/P-loop; other site 205918018821 ATP binding site [chemical binding]; other site 205918018822 Q-loop/lid; other site 205918018823 ABC transporter signature motif; other site 205918018824 Walker B; other site 205918018825 D-loop; other site 205918018826 H-loop/switch region; other site 205918018827 UreD urease accessory protein; Region: UreD; cl00530 205918018828 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 205918018829 alpha-gamma subunit interface [polypeptide binding]; other site 205918018830 beta-gamma subunit interface [polypeptide binding]; other site 205918018831 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 205918018832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918018833 Coenzyme A binding pocket [chemical binding]; other site 205918018834 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918018835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918018836 Coenzyme A binding pocket [chemical binding]; other site 205918018837 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 205918018838 gamma-beta subunit interface [polypeptide binding]; other site 205918018839 alpha-beta subunit interface [polypeptide binding]; other site 205918018840 urease subunit alpha; Reviewed; Region: ureC; PRK13207 205918018841 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 205918018842 subunit interactions [polypeptide binding]; other site 205918018843 active site 205918018844 flap region; other site 205918018845 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 205918018846 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 205918018847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918018848 dimer interface [polypeptide binding]; other site 205918018849 phosphorylation site [posttranslational modification] 205918018850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918018851 ATP binding site [chemical binding]; other site 205918018852 Mg2+ binding site [ion binding]; other site 205918018853 G-X-G motif; other site 205918018854 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 205918018855 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918018856 HSP70 interaction site [polypeptide binding]; other site 205918018857 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 205918018858 substrate binding site [polypeptide binding]; other site 205918018859 dimer interface [polypeptide binding]; other site 205918018860 putative chaperone; Provisional; Region: PRK11678 205918018861 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 205918018862 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018863 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018864 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018865 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018866 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018867 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018868 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018869 psiF repeat; Region: PsiF_repeat; pfam07769 205918018870 psiF repeat; Region: PsiF_repeat; pfam07769 205918018871 EamA-like transporter family; Region: EamA; cl01037 205918018872 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 205918018873 EamA-like transporter family; Region: EamA; cl01037 205918018874 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018875 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018876 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018877 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018878 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018879 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018880 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018881 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018882 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018883 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918018884 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 205918018885 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 205918018886 Ferritin-like domain; Region: Ferritin; pfam00210 205918018887 dinuclear metal binding motif [ion binding]; other site 205918018888 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 205918018889 AsmA-like C-terminal region; Region: AsmA_2; cl15864 205918018890 1 probable transmembrane helix predicted by TMHMM2.0 205918018891 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 205918018892 Helix-turn-helix domains; Region: HTH; cl00088 205918018893 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 205918018894 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 205918018895 dimer interface [polypeptide binding]; other site 205918018896 catalytic residues [active] 205918018897 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 205918018898 UreF; Region: UreF; pfam01730 205918018899 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918018900 HupE / UreJ protein; Region: HupE_UreJ; cl01011 205918018901 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018902 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018903 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018904 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018905 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018906 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018907 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918018908 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018909 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018910 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018911 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018912 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 205918018913 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 205918018914 dimerization interface [polypeptide binding]; other site 205918018915 active site 205918018916 thiamine monophosphate kinase; Provisional; Region: PRK05731 205918018917 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 205918018918 ATP binding site [chemical binding]; other site 205918018919 dimerization interface [polypeptide binding]; other site 205918018920 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 205918018921 putative RNA binding site [nucleotide binding]; other site 205918018922 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 205918018923 homopentamer interface [polypeptide binding]; other site 205918018924 active site 205918018925 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 205918018926 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 205918018927 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 205918018928 dimerization interface [polypeptide binding]; other site 205918018929 active site 205918018930 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 205918018931 Lumazine binding domain; Region: Lum_binding; pfam00677 205918018932 Lumazine binding domain; Region: Lum_binding; pfam00677 205918018933 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 205918018934 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 205918018935 catalytic motif [active] 205918018936 Zn binding site [ion binding]; other site 205918018937 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 205918018938 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 205918018939 ATP cone domain; Region: ATP-cone; pfam03477 205918018940 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 205918018941 Predicted methyltransferase [General function prediction only]; Region: COG3897 205918018942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918018943 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 205918018944 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 205918018945 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 205918018946 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 205918018947 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205918018948 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205918018949 Walker A/P-loop; other site 205918018950 ATP binding site [chemical binding]; other site 205918018951 Q-loop/lid; other site 205918018952 ABC transporter signature motif; other site 205918018953 Walker B; other site 205918018954 D-loop; other site 205918018955 H-loop/switch region; other site 205918018956 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205918018957 FtsX-like permease family; Region: FtsX; cl15850 205918018958 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018959 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018960 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018961 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918018962 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 205918018963 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 205918018964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918018965 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 205918018966 NAD(P) binding site [chemical binding]; other site 205918018967 active site 205918018968 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 205918018969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918018970 NAD(P) binding site [chemical binding]; other site 205918018971 active site 205918018972 putative mechanosensitive channel protein; Provisional; Region: PRK11465 205918018973 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918018974 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018975 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018976 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018977 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018978 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018979 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018980 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018981 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018982 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018983 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018984 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918018985 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918018986 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918018987 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918018988 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918018989 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 205918018990 Gram-negative bacterial tonB protein; Region: TonB; cl10048 205918018991 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 205918018992 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918018993 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918018994 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918018995 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 205918018996 1 probable transmembrane helix predicted by TMHMM2.0 205918018997 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918018998 N-terminal plug; other site 205918018999 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918019000 ligand-binding site [chemical binding]; other site 205918019001 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205918019002 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 205918019003 substrate binding site [chemical binding]; other site 205918019004 dimer interface [polypeptide binding]; other site 205918019005 ATP binding site [chemical binding]; other site 205918019006 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 205918019007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918019008 putative substrate translocation pore; other site 205918019009 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019010 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019011 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019012 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019013 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019014 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019015 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019016 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019017 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019018 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019019 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019020 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019021 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 205918019022 active site 205918019023 catalytic residues [active] 205918019024 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 205918019025 Helix-turn-helix domains; Region: HTH; cl00088 205918019026 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 205918019027 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 205918019028 intersubunit interface [polypeptide binding]; other site 205918019029 active site 205918019030 catalytic residue [active] 205918019031 PAS domain; Region: PAS_9; pfam13426 205918019032 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 205918019033 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918019034 metal binding site [ion binding]; metal-binding site 205918019035 active site 205918019036 I-site; other site 205918019037 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918019038 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019039 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019040 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 205918019041 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918019042 substrate binding pocket [chemical binding]; other site 205918019043 membrane-bound complex binding site; other site 205918019044 hinge residues; other site 205918019045 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 205918019046 Gram-negative bacterial tonB protein; Region: TonB; cl10048 205918019047 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 205918019048 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019049 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019050 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019051 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 205918019052 1 probable transmembrane helix predicted by TMHMM2.0 205918019053 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918019054 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918019055 N-terminal plug; other site 205918019056 ligand-binding site [chemical binding]; other site 205918019057 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 205918019058 catalytic core [active] 205918019059 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 205918019060 1 probable transmembrane helix predicted by TMHMM2.0 205918019061 Helix-turn-helix domains; Region: HTH; cl00088 205918019062 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205918019063 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205918019064 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205918019065 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918019066 1 probable transmembrane helix predicted by TMHMM2.0 205918019067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 205918019068 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019069 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019070 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019071 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019072 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019073 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918019075 dimer interface [polypeptide binding]; other site 205918019076 conserved gate region; other site 205918019077 putative PBP binding loops; other site 205918019078 ABC-ATPase subunit interface; other site 205918019079 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019080 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019081 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019082 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019083 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019084 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019085 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 205918019086 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 205918019087 Walker A/P-loop; other site 205918019088 ATP binding site [chemical binding]; other site 205918019089 Q-loop/lid; other site 205918019090 ABC transporter signature motif; other site 205918019091 Walker B; other site 205918019092 D-loop; other site 205918019093 H-loop/switch region; other site 205918019094 TOBE domain; Region: TOBE_2; cl01440 205918019095 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 205918019096 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 205918019097 putative active site [active] 205918019098 catalytic site [active] 205918019099 putative metal binding site [ion binding]; other site 205918019100 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 205918019101 active site 205918019102 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 205918019103 Domain of unknown function (DUF955); Region: DUF955; cl01076 205918019104 Beta protein; Region: Beta_protein; pfam14350 205918019105 SEC-C motif; Region: SEC-C; pfam02810 205918019106 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 205918019107 dimer interface [polypeptide binding]; other site 205918019108 ssDNA binding site [nucleotide binding]; other site 205918019109 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205918019110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918019111 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205918019112 putative substrate translocation pore; other site 205918019113 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019114 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019115 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019116 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019117 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019118 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019119 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019120 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019121 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019122 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019123 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019124 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918019125 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 205918019126 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 205918019127 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 205918019128 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 205918019129 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 205918019130 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 205918019131 heme binding site [chemical binding]; other site 205918019132 ferroxidase pore; other site 205918019133 ferroxidase diiron center [ion binding]; other site 205918019134 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 205918019135 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 205918019136 tetramer interface [polypeptide binding]; other site 205918019137 heme binding pocket [chemical binding]; other site 205918019138 NADPH binding site [chemical binding]; other site 205918019139 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 205918019140 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 205918019141 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 205918019142 alphaNTD homodimer interface [polypeptide binding]; other site 205918019143 alphaNTD - beta interaction site [polypeptide binding]; other site 205918019144 alphaNTD - beta' interaction site [polypeptide binding]; other site 205918019145 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 205918019146 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 205918019147 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 205918019148 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205918019149 RNA binding surface [nucleotide binding]; other site 205918019150 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 205918019151 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 205918019152 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 205918019153 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 205918019154 SecY translocase; Region: SecY; pfam00344 205918019155 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019156 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019157 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019158 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019159 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019160 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019161 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019162 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019163 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019164 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019165 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 205918019166 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 205918019167 23S rRNA binding site [nucleotide binding]; other site 205918019168 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 205918019169 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 205918019170 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 205918019171 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 205918019172 5S rRNA interface [nucleotide binding]; other site 205918019173 23S rRNA interface [nucleotide binding]; other site 205918019174 L5 interface [polypeptide binding]; other site 205918019175 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 205918019176 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 205918019177 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 205918019178 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 205918019179 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 205918019180 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 205918019181 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 205918019182 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 205918019183 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 205918019184 KOW motif; Region: KOW; cl00354 205918019185 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 205918019186 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 205918019187 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 205918019188 23S rRNA interface [nucleotide binding]; other site 205918019189 putative translocon interaction site; other site 205918019190 signal recognition particle (SRP54) interaction site; other site 205918019191 L23 interface [polypeptide binding]; other site 205918019192 trigger factor interaction site; other site 205918019193 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 205918019194 23S rRNA interface [nucleotide binding]; other site 205918019195 5S rRNA interface [nucleotide binding]; other site 205918019196 putative antibiotic binding site [chemical binding]; other site 205918019197 L25 interface [polypeptide binding]; other site 205918019198 L27 interface [polypeptide binding]; other site 205918019199 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 205918019200 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 205918019201 G-X-X-G motif; other site 205918019202 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 205918019203 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 205918019204 protein-rRNA interface [nucleotide binding]; other site 205918019205 putative translocon binding site; other site 205918019206 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 205918019207 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 205918019208 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 205918019209 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 205918019210 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 205918019211 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 205918019212 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 205918019213 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 205918019214 elongation factor Tu; Reviewed; Region: PRK00049 205918019215 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 205918019216 G1 box; other site 205918019217 GEF interaction site [polypeptide binding]; other site 205918019218 GTP/Mg2+ binding site [chemical binding]; other site 205918019219 Switch I region; other site 205918019220 G2 box; other site 205918019221 G3 box; other site 205918019222 Switch II region; other site 205918019223 G4 box; other site 205918019224 G5 box; other site 205918019225 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 205918019226 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 205918019227 Antibiotic Binding Site [chemical binding]; other site 205918019228 elongation factor G; Reviewed; Region: PRK00007 205918019229 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 205918019230 G1 box; other site 205918019231 putative GEF interaction site [polypeptide binding]; other site 205918019232 GTP/Mg2+ binding site [chemical binding]; other site 205918019233 Switch I region; other site 205918019234 G2 box; other site 205918019235 G3 box; other site 205918019236 Switch II region; other site 205918019237 G4 box; other site 205918019238 G5 box; other site 205918019239 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 205918019240 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 205918019241 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 205918019242 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 205918019243 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 205918019244 S17 interaction site [polypeptide binding]; other site 205918019245 S8 interaction site; other site 205918019246 16S rRNA interaction site [nucleotide binding]; other site 205918019247 streptomycin interaction site [chemical binding]; other site 205918019248 23S rRNA interaction site [nucleotide binding]; other site 205918019249 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 205918019250 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 205918019251 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 205918019252 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 205918019253 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 205918019254 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 205918019255 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 205918019256 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 205918019257 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 205918019258 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 205918019259 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 205918019260 DNA binding site [nucleotide binding] 205918019261 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 205918019262 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 205918019263 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 205918019264 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 205918019265 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 205918019266 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 205918019267 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 205918019268 RPB11 interaction site [polypeptide binding]; other site 205918019269 RPB12 interaction site [polypeptide binding]; other site 205918019270 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 205918019271 RPB3 interaction site [polypeptide binding]; other site 205918019272 RPB1 interaction site [polypeptide binding]; other site 205918019273 RPB11 interaction site [polypeptide binding]; other site 205918019274 RPB10 interaction site [polypeptide binding]; other site 205918019275 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 205918019276 peripheral dimer interface [polypeptide binding]; other site 205918019277 core dimer interface [polypeptide binding]; other site 205918019278 L10 interface [polypeptide binding]; other site 205918019279 L11 interface [polypeptide binding]; other site 205918019280 putative EF-Tu interaction site [polypeptide binding]; other site 205918019281 putative EF-G interaction site [polypeptide binding]; other site 205918019282 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 205918019283 23S rRNA interface [nucleotide binding]; other site 205918019284 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 205918019285 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 205918019286 mRNA/rRNA interface [nucleotide binding]; other site 205918019287 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 205918019288 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 205918019289 23S rRNA interface [nucleotide binding]; other site 205918019290 L7/L12 interface [polypeptide binding]; other site 205918019291 putative thiostrepton binding site; other site 205918019292 L25 interface [polypeptide binding]; other site 205918019293 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 205918019294 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 205918019295 putative homodimer interface [polypeptide binding]; other site 205918019296 KOW motif; Region: KOW; cl00354 205918019297 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 205918019298 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019299 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019300 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918019301 Type III pantothenate kinase; Region: Pan_kinase; cl09130 205918019302 Helix-turn-helix domains; Region: HTH; cl00088 205918019303 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 205918019304 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 205918019305 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 205918019306 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 205918019307 active site 205918019308 HIGH motif; other site 205918019309 dimer interface [polypeptide binding]; other site 205918019310 KMSKS motif; other site 205918019311 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 205918019312 putative peptidase; Provisional; Region: PRK11649 205918019313 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 205918019314 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 205918019315 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 205918019316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918019317 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 205918019318 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 205918019319 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019320 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019321 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019322 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019323 Protein of unknown function (DUF805); Region: DUF805; cl01224 205918019324 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019325 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019326 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019327 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019328 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 205918019329 classical (c) SDRs; Region: SDR_c; cd05233 205918019330 NAD(P) binding site [chemical binding]; other site 205918019331 active site 205918019332 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 205918019333 nucleotide binding site/active site [active] 205918019334 HIT family signature motif; other site 205918019335 catalytic residue [active] 205918019336 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 205918019337 diiron binding motif [ion binding]; other site 205918019338 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 205918019339 OsmC-like protein; Region: OsmC; cl00767 205918019340 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 205918019341 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 205918019342 ligand binding site [chemical binding]; other site 205918019343 flexible hinge region; other site 205918019344 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 205918019345 putative switch regulator; other site 205918019346 non-specific DNA interactions [nucleotide binding]; other site 205918019347 DNA binding site [nucleotide binding] 205918019348 sequence specific DNA binding site [nucleotide binding]; other site 205918019349 putative cAMP binding site [chemical binding]; other site 205918019350 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 205918019351 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 205918019352 active site 205918019353 ribulose/triose binding site [chemical binding]; other site 205918019354 phosphate binding site [ion binding]; other site 205918019355 substrate (anthranilate) binding pocket [chemical binding]; other site 205918019356 product (indole) binding pocket [chemical binding]; other site 205918019357 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 205918019358 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 205918019359 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 205918019360 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 205918019361 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 205918019362 glutamine binding [chemical binding]; other site 205918019363 catalytic triad [active] 205918019364 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 205918019365 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 205918019366 catalytic residue [active] 205918019367 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 205918019368 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 205918019369 Baseplate J-like protein; Region: Baseplate_J; cl01294 205918019370 Phage protein GP46; Region: GP46; cl01814 205918019371 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 205918019372 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 205918019373 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 205918019374 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 205918019375 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 205918019376 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 205918019377 Phage-related protein [Function unknown]; Region: COG5412 205918019378 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019379 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019380 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 205918019381 Phage tail tube protein; Region: Tail_tube; pfam10618 205918019382 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 205918019383 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 205918019384 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 205918019385 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 205918019386 1 probable transmembrane helix predicted by TMHMM2.0 205918019387 1 probable transmembrane helix predicted by TMHMM2.0 205918019388 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 205918019389 Mu-like prophage protein Com; Region: Mu-like_Com; cl11540 205918019390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205918019391 non-specific DNA binding site [nucleotide binding]; other site 205918019392 salt bridge; other site 205918019393 sequence-specific DNA binding site [nucleotide binding]; other site 205918019394 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205918019395 Catalytic site [active] 205918019396 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 205918019397 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 205918019398 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 205918019399 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 205918019400 active site 205918019401 catalytic triad [active] 205918019402 oxyanion hole [active] 205918019403 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 205918019404 1 probable transmembrane helix predicted by TMHMM2.0 205918019405 Helix-turn-helix domains; Region: HTH; cl00088 205918019406 putative transposase OrfB; Reviewed; Region: PHA02517 205918019407 HTH-like domain; Region: HTH_21; pfam13276 205918019408 Integrase core domain; Region: rve; cl01316 205918019409 Integrase core domain; Region: rve_3; cl15866 205918019410 anthranilate synthase component I; Provisional; Region: PRK13565 205918019411 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 205918019412 chorismate binding enzyme; Region: Chorismate_bind; cl10555 205918019413 phosphoglycolate phosphatase; Provisional; Region: PRK13223 205918019414 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918019415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918019416 motif II; other site 205918019417 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918019418 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 205918019419 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 205918019420 substrate binding site [chemical binding]; other site 205918019421 hexamer interface [polypeptide binding]; other site 205918019422 metal binding site [ion binding]; metal-binding site 205918019423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918019424 dimer interface [polypeptide binding]; other site 205918019425 conserved gate region; other site 205918019426 putative PBP binding loops; other site 205918019427 ABC-ATPase subunit interface; other site 205918019428 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019429 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019430 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019431 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019432 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019433 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918019435 dimer interface [polypeptide binding]; other site 205918019436 conserved gate region; other site 205918019437 putative PBP binding loops; other site 205918019438 ABC-ATPase subunit interface; other site 205918019439 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019440 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019441 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019442 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019443 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019444 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019445 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 205918019446 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918019447 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205918019448 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 205918019449 Walker A/P-loop; other site 205918019450 ATP binding site [chemical binding]; other site 205918019451 Q-loop/lid; other site 205918019452 ABC transporter signature motif; other site 205918019453 Walker B; other site 205918019454 D-loop; other site 205918019455 H-loop/switch region; other site 205918019456 TOBE domain; Region: TOBE_2; cl01440 205918019457 putative transposase OrfB; Reviewed; Region: PHA02517 205918019458 HTH-like domain; Region: HTH_21; pfam13276 205918019459 Integrase core domain; Region: rve; cl01316 205918019460 Integrase core domain; Region: rve_3; cl15866 205918019461 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918019462 Helix-turn-helix domains; Region: HTH; cl00088 205918019463 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205918019464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918019465 active site 205918019466 phosphorylation site [posttranslational modification] 205918019467 intermolecular recognition site; other site 205918019468 dimerization interface [polypeptide binding]; other site 205918019469 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918019470 DNA binding residues [nucleotide binding] 205918019471 dimerization interface [polypeptide binding]; other site 205918019472 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918019473 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918019474 substrate binding pocket [chemical binding]; other site 205918019475 membrane-bound complex binding site; other site 205918019476 hinge residues; other site 205918019477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918019478 PAS domain; Region: PAS_9; pfam13426 205918019479 putative active site [active] 205918019480 heme pocket [chemical binding]; other site 205918019481 Histidine kinase; Region: HisKA_3; pfam07730 205918019482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918019483 ATP binding site [chemical binding]; other site 205918019484 Mg2+ binding site [ion binding]; other site 205918019485 G-X-G motif; other site 205918019486 1 probable transmembrane helix predicted by TMHMM2.0 205918019487 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 205918019488 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 205918019489 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 205918019490 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 205918019491 putative metal binding site [ion binding]; other site 205918019492 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918019493 HSP70 interaction site [polypeptide binding]; other site 205918019494 1 probable transmembrane helix predicted by TMHMM2.0 205918019495 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 205918019496 Substrate binding site; other site 205918019497 metal-binding site 205918019498 Phosphotransferase enzyme family; Region: APH; pfam01636 205918019499 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 205918019500 active site 205918019501 ATP binding site [chemical binding]; other site 205918019502 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 205918019503 OstA-like protein; Region: OstA; cl00844 205918019504 Organic solvent tolerance protein; Region: OstA_C; pfam04453 205918019505 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 205918019506 SurA N-terminal domain; Region: SurA_N_3; cl07813 205918019507 PPIC-type PPIASE domain; Region: Rotamase; cl08278 205918019508 PPIC-type PPIASE domain; Region: Rotamase; cl08278 205918019509 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 205918019510 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 205918019511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918019512 Protein of unknown function (DUF525); Region: DUF525; cl01119 205918019513 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 205918019514 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 205918019515 active site 205918019516 metal binding site [ion binding]; metal-binding site 205918019517 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 205918019518 active site residue [active] 205918019519 PrkA family serine protein kinase; Provisional; Region: PRK15455 205918019520 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 205918019521 Uncharacterized conserved protein [Function unknown]; Region: COG2718 205918019522 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 205918019523 SpoVR family protein; Provisional; Region: PRK11767 205918019524 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 205918019525 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 205918019526 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 205918019527 active site 205918019528 NTP binding site [chemical binding]; other site 205918019529 metal binding triad [ion binding]; metal-binding site 205918019530 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 205918019531 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205918019532 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 205918019533 catalytic center binding site [active] 205918019534 ATP binding site [chemical binding]; other site 205918019535 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 205918019536 homooctamer interface [polypeptide binding]; other site 205918019537 active site 205918019538 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 205918019539 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019540 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019541 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019542 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019543 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019544 UGMP family protein; Validated; Region: PRK09604 205918019545 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 205918019546 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 205918019547 DNA primase; Validated; Region: dnaG; PRK05667 205918019548 CHC2 zinc finger; Region: zf-CHC2; cl15369 205918019549 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 205918019550 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 205918019551 active site 205918019552 metal binding site [ion binding]; metal-binding site 205918019553 interdomain interaction site; other site 205918019554 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 205918019555 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 205918019556 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 205918019557 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 205918019558 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 205918019559 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 205918019560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918019561 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 205918019562 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918019563 DNA binding residues [nucleotide binding] 205918019564 1 probable transmembrane helix predicted by TMHMM2.0 205918019565 PAS domain S-box; Region: sensory_box; TIGR00229 205918019566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918019567 putative active site [active] 205918019568 heme pocket [chemical binding]; other site 205918019569 PAS domain S-box; Region: sensory_box; TIGR00229 205918019570 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918019571 putative active site [active] 205918019572 heme pocket [chemical binding]; other site 205918019573 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918019574 PAS domain; Region: PAS_9; pfam13426 205918019575 putative active site [active] 205918019576 heme pocket [chemical binding]; other site 205918019577 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918019578 metal binding site [ion binding]; metal-binding site 205918019579 active site 205918019580 I-site; other site 205918019581 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918019582 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 205918019583 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019584 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019585 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019586 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019587 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019588 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 205918019589 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 205918019590 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205918019591 active site 205918019592 DNA binding site [nucleotide binding] 205918019593 Int/Topo IB signature motif; other site 205918019594 arginine decarboxylase; Provisional; Region: PRK15029 205918019595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918019596 Coenzyme A binding pocket [chemical binding]; other site 205918019597 ISPpu14, transposase Orf3 205918019598 S-type Pyocin; Region: Pyocin_S; pfam06958 205918019599 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 205918019600 active site 205918019601 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 205918019602 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019603 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019604 hypothetical protein 205918019605 similar to Type II secretory pathway component ExeA (predicted ATPase) 205918019606 AvrPtoB E3 ubiquitin ligase; Region: AvrPtoB-E3_ubiq; pfam09046 205918019607 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 205918019608 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019609 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019610 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019611 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019612 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019613 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019614 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 205918019615 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 205918019616 AMP-binding enzyme; Region: AMP-binding; cl15778 205918019617 AMP-binding enzyme; Region: AMP-binding; cl15778 205918019618 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 205918019619 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 205918019620 putative trimer interface [polypeptide binding]; other site 205918019621 putative CoA binding site [chemical binding]; other site 205918019622 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 205918019623 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 205918019624 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019625 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019626 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019627 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019628 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918019629 Fic family protein [Function unknown]; Region: COG3177 205918019630 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 205918019631 Fic/DOC family; Region: Fic; cl00960 205918019632 Predicted membrane protein [Function unknown]; Region: COG1289 205918019633 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 205918019634 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019635 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019636 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019637 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019638 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019639 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019640 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205918019641 Helix-turn-helix domains; Region: HTH; cl00088 205918019642 AsnC family; Region: AsnC_trans_reg; pfam01037 205918019643 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 205918019644 Predicted amidohydrolase [General function prediction only]; Region: COG0388 205918019645 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 205918019646 putative active site [active] 205918019647 catalytic triad [active] 205918019648 putative dimer interface [polypeptide binding]; other site 205918019649 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 205918019650 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 205918019651 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 205918019652 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 205918019653 PqqA family; Region: PqqA; cl15372 205918019654 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 205918019655 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 205918019656 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 205918019657 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 205918019658 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918019659 FeS/SAM binding site; other site 205918019660 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 205918019661 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 205918019662 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918019663 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 205918019664 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019665 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019666 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 205918019667 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 205918019668 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918019669 active site 205918019670 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 205918019671 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918019672 metal binding site [ion binding]; metal-binding site 205918019673 active site 205918019674 I-site; other site 205918019675 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019676 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019677 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019678 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019679 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019680 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019681 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918019682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918019683 Helix-turn-helix domains; Region: HTH; cl00088 205918019684 putative transposase OrfB; Reviewed; Region: PHA02517 205918019685 HTH-like domain; Region: HTH_21; pfam13276 205918019686 Integrase core domain; Region: rve; cl01316 205918019687 Integrase core domain; Region: rve_3; cl15866 205918019688 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 205918019689 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 205918019690 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 205918019691 active site 205918019692 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 205918019693 AAA domain; Region: AAA_26; pfam13500 205918019694 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918019695 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918019696 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 205918019697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918019698 S-adenosylmethionine binding site [chemical binding]; other site 205918019699 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 205918019700 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 205918019701 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 205918019702 substrate-cofactor binding pocket; other site 205918019703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918019704 catalytic residue [active] 205918019705 biotin synthase; Provisional; Region: PRK15108 205918019706 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205918019707 FeS/SAM binding site; other site 205918019708 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 205918019709 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 205918019710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205918019711 active site 205918019712 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 205918019713 Helix-turn-helix domains; Region: HTH; cl00088 205918019714 TOBE domain; Region: TOBE_2; cl01440 205918019715 TOBE domain; Region: TOBE_2; cl01440 205918019716 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 205918019717 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 205918019718 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 205918019719 active site 205918019720 metal binding site [ion binding]; metal-binding site 205918019721 hexamer interface [polypeptide binding]; other site 205918019722 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205918019723 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918019724 Walker A/P-loop; other site 205918019725 ATP binding site [chemical binding]; other site 205918019726 Q-loop/lid; other site 205918019727 ABC transporter signature motif; other site 205918019728 Walker B; other site 205918019729 D-loop; other site 205918019730 H-loop/switch region; other site 205918019731 TOBE domain; Region: TOBE_2; cl01440 205918019732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918019733 dimer interface [polypeptide binding]; other site 205918019734 conserved gate region; other site 205918019735 putative PBP binding loops; other site 205918019736 ABC-ATPase subunit interface; other site 205918019737 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019738 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019739 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019740 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019741 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019742 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918019744 dimer interface [polypeptide binding]; other site 205918019745 conserved gate region; other site 205918019746 putative PBP binding loops; other site 205918019747 ABC-ATPase subunit interface; other site 205918019748 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019749 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019750 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019751 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019752 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019753 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019754 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918019755 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205918019756 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205918019757 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205918019758 DNA binding site [nucleotide binding] 205918019759 domain linker motif; other site 205918019760 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 205918019761 putative dimerization interface [polypeptide binding]; other site 205918019762 putative ligand binding site [chemical binding]; other site 205918019763 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918019764 Phosphotransferase enzyme family; Region: APH; pfam01636 205918019765 Predicted permeases [General function prediction only]; Region: RarD; COG2962 205918019766 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019767 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019768 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019769 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019770 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019771 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019772 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019773 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019774 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019775 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918019776 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 205918019777 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 205918019778 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 205918019779 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 205918019780 active site 205918019781 Response regulator receiver domain; Region: Response_reg; pfam00072 205918019782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918019783 active site 205918019784 phosphorylation site [posttranslational modification] 205918019785 intermolecular recognition site; other site 205918019786 dimerization interface [polypeptide binding]; other site 205918019787 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 205918019788 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 205918019789 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 205918019790 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205918019791 metal binding triad; other site 205918019792 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 205918019793 active site 205918019794 catalytic site [active] 205918019795 substrate binding site [chemical binding]; other site 205918019796 Cell division protein ZapA; Region: ZapA; cl01146 205918019797 rod shape-determining protein MreC; Provisional; Region: PRK13922 205918019798 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918019799 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 205918019800 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918019801 dimer interface [polypeptide binding]; other site 205918019802 putative CheW interface [polypeptide binding]; other site 205918019803 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019804 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019805 Transposase IS200 like; Region: Y1_Tnp; cl00848 205918019806 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 205918019807 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 205918019808 conserved cys residue [active] 205918019809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918019810 NMT1-like family; Region: NMT1_2; cl15260 205918019811 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 205918019812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918019813 dimer interface [polypeptide binding]; other site 205918019814 conserved gate region; other site 205918019815 putative PBP binding loops; other site 205918019816 ABC-ATPase subunit interface; other site 205918019817 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019818 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019819 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019820 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019821 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019822 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918019823 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 205918019824 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918019825 Walker A/P-loop; other site 205918019826 ATP binding site [chemical binding]; other site 205918019827 Q-loop/lid; other site 205918019828 ABC transporter signature motif; other site 205918019829 Walker B; other site 205918019830 D-loop; other site 205918019831 H-loop/switch region; other site 205918019832 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 205918019833 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 205918019834 dimer interface [polypeptide binding]; other site 205918019835 active site 205918019836 glycine-pyridoxal phosphate binding site [chemical binding]; other site 205918019837 folate binding site [chemical binding]; other site 205918019838 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 205918019839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918019840 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 205918019841 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 205918019842 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 205918019843 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 205918019844 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 205918019845 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 205918019846 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 205918019847 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 205918019848 putative active site [active] 205918019849 putative substrate binding site [chemical binding]; other site 205918019850 putative cosubstrate binding site; other site 205918019851 catalytic site [active] 205918019852 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 205918019853 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 205918019854 NAD binding site [chemical binding]; other site 205918019855 catalytic Zn binding site [ion binding]; other site 205918019856 structural Zn binding site [ion binding]; other site 205918019857 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918019858 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918019859 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 205918019860 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918019861 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 205918019862 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 205918019863 putative acyl-acceptor binding pocket; other site 205918019864 1 probable transmembrane helix predicted by TMHMM2.0 205918019865 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 205918019866 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 205918019867 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 205918019868 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 205918019869 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 205918019870 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 205918019871 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 205918019872 putative glutathione S-transferase; Provisional; Region: PRK10357 205918019873 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 205918019874 putative C-terminal domain interface [polypeptide binding]; other site 205918019875 putative GSH binding site (G-site) [chemical binding]; other site 205918019876 putative dimer interface [polypeptide binding]; other site 205918019877 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 205918019878 N-terminal domain interface [polypeptide binding]; other site 205918019879 dimer interface [polypeptide binding]; other site 205918019880 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019881 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019882 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 205918019883 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 205918019884 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 205918019885 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019886 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019887 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019888 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019889 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 205918019890 FecR protein; Region: FecR; pfam04773 205918019891 1 probable transmembrane helix predicted by TMHMM2.0 205918019892 RNA polymerase sigma factor; Reviewed; Region: PRK12523 205918019893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918019894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918019895 DNA binding residues [nucleotide binding] 205918019896 choline dehydrogenase; Validated; Region: PRK02106 205918019897 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 205918019898 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 205918019899 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 205918019900 NAD(P) binding site [chemical binding]; other site 205918019901 catalytic residues [active] 205918019902 transcriptional regulator BetI; Validated; Region: PRK00767 205918019903 Helix-turn-helix domains; Region: HTH; cl00088 205918019904 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 205918019905 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918019906 G1 box; other site 205918019907 GTP/Mg2+ binding site [chemical binding]; other site 205918019908 G2 box; other site 205918019909 Switch I region; other site 205918019910 G3 box; other site 205918019911 Switch II region; other site 205918019912 G4 box; other site 205918019913 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 205918019914 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 205918019915 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019916 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019917 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019918 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019919 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 205918019920 folate binding site [chemical binding]; other site 205918019921 NADP+ binding site [chemical binding]; other site 205918019922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918019923 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 205918019924 ThiS interaction site; other site 205918019925 putative active site [active] 205918019926 tetramer interface [polypeptide binding]; other site 205918019927 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 205918019928 thiS-thiF/thiG interaction site; other site 205918019929 Protein of unknown function (DUF423); Region: DUF423; cl01008 205918019930 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019931 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019932 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019933 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019934 Transglycosylase; Region: Transgly; cl07896 205918019935 1 probable transmembrane helix predicted by TMHMM2.0 205918019936 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 205918019937 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 205918019938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205918019939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205918019940 DNA binding residues [nucleotide binding] 205918019941 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 205918019942 FtsX-like permease family; Region: FtsX; cl15850 205918019943 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019944 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019945 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019946 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918019947 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 205918019948 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918019949 Walker A/P-loop; other site 205918019950 ATP binding site [chemical binding]; other site 205918019951 Q-loop/lid; other site 205918019952 ABC transporter signature motif; other site 205918019953 Walker B; other site 205918019954 D-loop; other site 205918019955 H-loop/switch region; other site 205918019956 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 205918019957 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 205918019958 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 205918019959 P loop; other site 205918019960 GTP binding site [chemical binding]; other site 205918019961 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 205918019962 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 205918019963 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 205918019964 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 205918019965 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 205918019966 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 205918019967 1 probable transmembrane helix predicted by TMHMM2.0 205918019968 Methyltransferase domain; Region: Methyltransf_31; pfam13847 205918019969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918019970 S-adenosylmethionine binding site [chemical binding]; other site 205918019971 putative hydrolase; Provisional; Region: PRK10985 205918019972 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 205918019973 nucleophilic elbow; other site 205918019974 catalytic triad; other site 205918019975 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 205918019976 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 205918019977 active site residue [active] 205918019978 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 205918019979 active site residue [active] 205918019980 Helix-turn-helix domains; Region: HTH; cl00088 205918019981 Bacterial transcriptional repressor; Region: TetR; pfam13972 205918019982 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 205918019983 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 205918019984 active site 205918019985 (T/H)XGH motif; other site 205918019986 methylamine methyltransferase corrinoid protein reductive activase; Region: Rama_corrin_act; TIGR04270 205918019987 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019988 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918019989 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 205918019990 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 205918019991 DNA binding site [nucleotide binding] 205918019992 catalytic residue [active] 205918019993 H2TH interface [polypeptide binding]; other site 205918019994 putative catalytic residues [active] 205918019995 turnover-facilitating residue; other site 205918019996 intercalation triad [nucleotide binding]; other site 205918019997 8OG recognition residue [nucleotide binding]; other site 205918019998 putative reading head residues; other site 205918019999 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 205918020000 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 205918020001 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 205918020002 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 205918020003 intracellular protease, PfpI family; Region: PfpI; TIGR01382 205918020004 proposed catalytic triad [active] 205918020005 conserved cys residue [active] 205918020006 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 205918020007 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 205918020008 putative RNA binding site [nucleotide binding]; other site 205918020009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918020010 S-adenosylmethionine binding site [chemical binding]; other site 205918020011 TraX protein; Region: TraX; cl05434 205918020012 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020013 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020014 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020015 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020016 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020017 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020018 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 205918020019 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 205918020020 tetramer interface [polypeptide binding]; other site 205918020021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918020022 catalytic residue [active] 205918020023 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 205918020024 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 205918020025 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 205918020026 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 205918020027 putative transporter; Provisional; Region: PRK10504 205918020028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918020029 putative substrate translocation pore; other site 205918020030 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020031 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020032 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020033 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020034 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020035 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020036 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020037 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020038 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020039 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020040 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020041 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020042 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020043 1 of 14 probable transmembrane helices predicted by TMHMM2.0 205918020044 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 205918020045 GAF domain; Region: GAF; cl15785 205918020046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918020047 PAS domain; Region: PAS_9; pfam13426 205918020048 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 205918020049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 205918020050 metal binding site [ion binding]; metal-binding site 205918020051 active site 205918020052 I-site; other site 205918020053 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 205918020054 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 205918020055 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 205918020056 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 205918020057 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 205918020058 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 205918020059 FAD binding pocket [chemical binding]; other site 205918020060 FAD binding motif [chemical binding]; other site 205918020061 phosphate binding motif [ion binding]; other site 205918020062 beta-alpha-beta structure motif; other site 205918020063 NAD binding pocket [chemical binding]; other site 205918020064 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 205918020065 catalytic loop [active] 205918020066 iron binding site [ion binding]; other site 205918020067 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 205918020068 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 205918020069 [2Fe-2S] cluster binding site [ion binding]; other site 205918020070 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 205918020071 putative alpha subunit interface [polypeptide binding]; other site 205918020072 putative active site [active] 205918020073 putative substrate binding site [chemical binding]; other site 205918020074 Fe binding site [ion binding]; other site 205918020075 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 205918020076 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 205918020077 putative active site [active] 205918020078 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 205918020079 Interdomain contacts; other site 205918020080 Cytokine receptor motif; other site 205918020081 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 205918020082 Interdomain contacts; other site 205918020083 Cytokine receptor motif; other site 205918020084 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 205918020085 Interdomain contacts; other site 205918020086 Cytokine receptor motif; other site 205918020087 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 205918020088 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 205918020089 Catalytic domain of Arabidopsis thaliana PI-PLC X domain-containing protein At5g67130 and its uncharacterized homologs; Region: PI-PLCc_At5g67130_like; cd08588 205918020090 putative active site [active] 205918020091 catalytic site [active] 205918020092 1 probable transmembrane helix predicted by TMHMM2.0 205918020093 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 205918020094 Ligand Binding Site [chemical binding]; other site 205918020095 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 205918020096 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 205918020097 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 205918020098 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 205918020099 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 205918020100 Cysteine-rich domain; Region: CCG; pfam02754 205918020101 Cysteine-rich domain; Region: CCG; pfam02754 205918020102 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020103 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020104 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020105 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020106 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020107 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 205918020108 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 205918020109 putative active site [active] 205918020110 putative FMN binding site [chemical binding]; other site 205918020111 putative substrate binding site [chemical binding]; other site 205918020112 putative catalytic residue [active] 205918020113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918020114 Heme NO binding; Region: HNOB; cl15268 205918020115 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 205918020116 active site 205918020117 dimer interface [polypeptide binding]; other site 205918020118 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 205918020119 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 205918020120 hypothetical protein; Provisional; Region: PRK08185 205918020121 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 205918020122 intersubunit interface [polypeptide binding]; other site 205918020123 active site 205918020124 zinc binding site [ion binding]; other site 205918020125 Na+ binding site [ion binding]; other site 205918020126 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 205918020127 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 205918020128 Phosphoglycerate kinase; Region: PGK; pfam00162 205918020129 substrate binding site [chemical binding]; other site 205918020130 hinge regions; other site 205918020131 ADP binding site [chemical binding]; other site 205918020132 catalytic site [active] 205918020133 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 205918020134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918020135 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 205918020136 transketolase; Reviewed; Region: PRK12753 205918020137 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 205918020138 TPP-binding site [chemical binding]; other site 205918020139 dimer interface [polypeptide binding]; other site 205918020140 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 205918020141 PYR/PP interface [polypeptide binding]; other site 205918020142 dimer interface [polypeptide binding]; other site 205918020143 TPP binding site [chemical binding]; other site 205918020144 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 205918020145 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205918020146 putative DNA binding site [nucleotide binding]; other site 205918020147 dimerization interface [polypeptide binding]; other site 205918020148 putative Zn2+ binding site [ion binding]; other site 205918020149 Methyltransferase domain; Region: Methyltransf_31; pfam13847 205918020150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918020151 S-adenosylmethionine binding site [chemical binding]; other site 205918020152 S-adenosylmethionine synthetase; Validated; Region: PRK05250 205918020153 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 205918020154 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 205918020155 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 205918020156 LysE type translocator; Region: LysE; cl00565 205918020157 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020158 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020159 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020160 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020161 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020162 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 205918020163 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 205918020164 nucleotide binding pocket [chemical binding]; other site 205918020165 K-X-D-G motif; other site 205918020166 catalytic site [active] 205918020167 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 205918020168 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 205918020169 MAPEG family; Region: MAPEG; cl09190 205918020170 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020171 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020172 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020173 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 205918020174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918020175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918020176 dimer interface [polypeptide binding]; other site 205918020177 phosphorylation site [posttranslational modification] 205918020178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918020179 ATP binding site [chemical binding]; other site 205918020180 Mg2+ binding site [ion binding]; other site 205918020181 G-X-G motif; other site 205918020182 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020183 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020184 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 205918020185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918020186 active site 205918020187 phosphorylation site [posttranslational modification] 205918020188 intermolecular recognition site; other site 205918020189 dimerization interface [polypeptide binding]; other site 205918020190 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918020191 DNA binding site [nucleotide binding] 205918020192 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 205918020193 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918020194 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 205918020195 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 205918020196 1 probable transmembrane helix predicted by TMHMM2.0 205918020197 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 205918020198 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020199 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020200 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020201 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020202 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020203 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020204 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020205 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020206 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020207 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020208 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020209 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020210 PAAR motif; Region: PAAR_motif; cl15808 205918020211 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918020212 RHS Repeat; Region: RHS_repeat; cl11982 205918020213 RHS Repeat; Region: RHS_repeat; cl11982 205918020214 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918020215 RHS protein; Region: RHS; pfam03527 205918020216 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020217 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020218 outer membrane porin, OprD family; Region: OprD; pfam03573 205918020219 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 205918020220 1 probable transmembrane helix predicted by TMHMM2.0 205918020221 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 205918020222 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 205918020223 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020224 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020225 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020226 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020227 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020228 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020229 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020230 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020231 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020232 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020233 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020234 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020235 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020236 Cupin domain; Region: Cupin_2; cl09118 205918020237 Helix-turn-helix domain; Region: HTH_18; pfam12833 205918020238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205918020239 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205918020240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918020241 sorbitol dehydrogenase; Provisional; Region: PRK07067 205918020242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918020243 NAD(P) binding site [chemical binding]; other site 205918020244 active site 205918020245 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 205918020246 Helix-turn-helix domains; Region: HTH; cl00088 205918020247 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 205918020248 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 205918020249 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 205918020250 G1 box; other site 205918020251 putative GEF interaction site [polypeptide binding]; other site 205918020252 GTP/Mg2+ binding site [chemical binding]; other site 205918020253 Switch I region; other site 205918020254 G2 box; other site 205918020255 G3 box; other site 205918020256 Switch II region; other site 205918020257 G4 box; other site 205918020258 G5 box; other site 205918020259 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 205918020260 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 205918020261 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 205918020262 THUMP domain; Region: THUMP; cl12076 205918020263 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 205918020264 Ligand Binding Site [chemical binding]; other site 205918020265 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 205918020266 glutamine synthetase; Provisional; Region: glnA; PRK09469 205918020267 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 205918020268 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205918020269 Chorismate mutase type II; Region: CM_2; cl00693 205918020270 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 205918020271 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 205918020272 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 205918020273 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918020274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918020275 dimer interface [polypeptide binding]; other site 205918020276 phosphorylation site [posttranslational modification] 205918020277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918020278 ATP binding site [chemical binding]; other site 205918020279 Mg2+ binding site [ion binding]; other site 205918020280 G-X-G motif; other site 205918020281 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 205918020282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918020283 active site 205918020284 phosphorylation site [posttranslational modification] 205918020285 intermolecular recognition site; other site 205918020286 dimerization interface [polypeptide binding]; other site 205918020287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918020288 Walker A motif; other site 205918020289 ATP binding site [chemical binding]; other site 205918020290 Walker B motif; other site 205918020291 arginine finger; other site 205918020292 Helix-turn-helix domains; Region: HTH; cl00088 205918020293 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 205918020294 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918020295 active site 205918020296 catalytic tetrad [active] 205918020297 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918020298 substrate binding pocket [chemical binding]; other site 205918020299 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918020300 membrane-bound complex binding site; other site 205918020301 hinge residues; other site 205918020302 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 205918020303 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 205918020304 active site 205918020305 non-prolyl cis peptide bond; other site 205918020306 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 205918020307 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 205918020308 N-terminal plug; other site 205918020309 ligand-binding site [chemical binding]; other site 205918020310 BCCT family transporter; Region: BCCT; cl00569 205918020311 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020312 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020313 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020314 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020315 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020316 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020317 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020318 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020319 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020320 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020321 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020322 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020323 urocanate hydratase; Provisional; Region: PRK05414 205918020324 urocanate hydratase; Region: hutU; TIGR01228 205918020325 NMT1-like family; Region: NMT1_2; cl15260 205918020326 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 205918020327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918020328 dimer interface [polypeptide binding]; other site 205918020329 conserved gate region; other site 205918020330 putative PBP binding loops; other site 205918020331 ABC-ATPase subunit interface; other site 205918020332 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020333 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020334 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020335 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020336 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020337 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020338 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 205918020339 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205918020340 Walker A/P-loop; other site 205918020341 ATP binding site [chemical binding]; other site 205918020342 Q-loop/lid; other site 205918020343 ABC transporter signature motif; other site 205918020344 Walker B; other site 205918020345 D-loop; other site 205918020346 H-loop/switch region; other site 205918020347 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 205918020348 active sites [active] 205918020349 tetramer interface [polypeptide binding]; other site 205918020350 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 205918020351 active sites [active] 205918020352 tetramer interface [polypeptide binding]; other site 205918020353 putative proline-specific permease; Provisional; Region: proY; PRK10580 205918020354 Spore germination protein; Region: Spore_permease; cl15802 205918020355 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020356 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020357 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020358 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020359 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020360 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020361 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020362 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020363 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020364 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020365 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020366 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020367 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020368 imidazolonepropionase; Validated; Region: PRK09356 205918020369 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 205918020370 active site 205918020371 N-formylglutamate amidohydrolase; Region: FGase; cl01522 205918020372 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 205918020373 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 205918020374 metal-binding site [ion binding] 205918020375 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205918020376 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918020377 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020378 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020379 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020380 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020381 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020382 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 205918020383 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 205918020384 DNA binding residues [nucleotide binding] 205918020385 dimer interface [polypeptide binding]; other site 205918020386 putative metal binding site [ion binding]; other site 205918020387 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020388 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020389 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020390 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 205918020391 dimerization interface [polypeptide binding]; other site 205918020392 active site 205918020393 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 205918020394 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020395 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020396 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020397 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020398 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020399 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020400 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918020401 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 205918020402 GAF domain; Region: GAF; cl15785 205918020403 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 205918020404 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 205918020405 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 205918020406 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 205918020407 putative active site [active] 205918020408 Ap4A binding site [chemical binding]; other site 205918020409 nudix motif; other site 205918020410 putative metal binding site [ion binding]; other site 205918020411 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 205918020412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918020413 motif II; other site 205918020414 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 205918020415 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020416 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020417 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020418 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020419 threonine dehydratase; Reviewed; Region: PRK09224 205918020420 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 205918020421 tetramer interface [polypeptide binding]; other site 205918020422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918020423 catalytic residue [active] 205918020424 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 205918020425 putative Ile/Val binding site [chemical binding]; other site 205918020426 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 205918020427 putative Ile/Val binding site [chemical binding]; other site 205918020428 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 205918020429 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205918020430 active site 205918020431 dimer interface [polypeptide binding]; other site 205918020432 SdiA-regulated; Region: SdiA-regulated; pfam06977 205918020433 SdiA-regulated; Region: SdiA-regulated; cd09971 205918020434 putative active site [active] 205918020435 1 probable transmembrane helix predicted by TMHMM2.0 205918020436 SdiA-regulated; Region: SdiA-regulated; pfam06977 205918020437 SdiA-regulated; Region: SdiA-regulated; cd09971 205918020438 putative active site [active] 205918020439 1 probable transmembrane helix predicted by TMHMM2.0 205918020440 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 205918020441 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 205918020442 FAD binding domain; Region: FAD_binding_4; pfam01565 205918020443 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 205918020444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918020445 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 205918020446 L-serine binding site [chemical binding]; other site 205918020447 ACT domain interface; other site 205918020448 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 205918020449 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 205918020450 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 205918020451 eukaryotic translation initiation factor 2 subunit 1; Provisional; Region: PTZ00248 205918020452 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 205918020453 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020454 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020455 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 205918020456 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205918020457 Penicillin amidase; Region: Penicil_amidase; pfam01804 205918020458 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 205918020459 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 205918020460 active site 205918020461 1 probable transmembrane helix predicted by TMHMM2.0 205918020462 Helix-turn-helix domains; Region: HTH; cl00088 205918020463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205918020464 putative transposase OrfB; Reviewed; Region: PHA02517 205918020465 HTH-like domain; Region: HTH_21; pfam13276 205918020466 Integrase core domain; Region: rve; cl01316 205918020467 Integrase core domain; Region: rve_3; cl15866 205918020468 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205918020469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918020470 dimer interface [polypeptide binding]; other site 205918020471 conserved gate region; other site 205918020472 putative PBP binding loops; other site 205918020473 ABC-ATPase subunit interface; other site 205918020474 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020475 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020476 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020477 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020478 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020479 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918020481 dimer interface [polypeptide binding]; other site 205918020482 conserved gate region; other site 205918020483 putative PBP binding loops; other site 205918020484 ABC-ATPase subunit interface; other site 205918020485 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020486 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020487 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020488 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020489 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020490 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020491 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 205918020492 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918020493 Walker A/P-loop; other site 205918020494 ATP binding site [chemical binding]; other site 205918020495 Q-loop/lid; other site 205918020496 ABC transporter signature motif; other site 205918020497 Walker B; other site 205918020498 D-loop; other site 205918020499 H-loop/switch region; other site 205918020500 TOBE domain; Region: TOBE_2; cl01440 205918020501 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 205918020502 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918020503 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 205918020504 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918020505 putative aminotransferase; Validated; Region: PRK07480 205918020506 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918020507 inhibitor-cofactor binding pocket; inhibition site 205918020508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918020509 catalytic residue [active] 205918020510 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 205918020511 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205918020512 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 205918020513 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205918020514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205918020515 Helix-turn-helix domains; Region: HTH; cl00088 205918020516 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918020517 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918020518 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918020519 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 205918020520 TOBE domain; Region: TOBE_2; cl01440 205918020521 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 205918020522 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918020523 Walker A/P-loop; other site 205918020524 ATP binding site [chemical binding]; other site 205918020525 Q-loop/lid; other site 205918020526 ABC transporter signature motif; other site 205918020527 Walker B; other site 205918020528 D-loop; other site 205918020529 H-loop/switch region; other site 205918020530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918020531 dimer interface [polypeptide binding]; other site 205918020532 conserved gate region; other site 205918020533 putative PBP binding loops; other site 205918020534 ABC-ATPase subunit interface; other site 205918020535 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918020536 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918020537 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918020538 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918020539 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918020540 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918020541 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918020542 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918020543 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 205918020544 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918020545 substrate binding pocket [chemical binding]; other site 205918020546 membrane-bound complex binding site; other site 205918020547 hinge residues; other site 205918020548 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 205918020549 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 205918020550 dimer interface [polypeptide binding]; other site 205918020551 decamer (pentamer of dimers) interface [polypeptide binding]; other site 205918020552 catalytic triad [active] 205918020553 outer membrane porin, OprD family; Region: OprD; pfam03573 205918020554 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 205918020555 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 205918020556 SecA binding site; other site 205918020557 Preprotein binding site; other site 205918020558 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 205918020559 GSH binding site [chemical binding]; other site 205918020560 catalytic residues [active] 205918020561 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 205918020562 active site residue [active] 205918020563 1 probable transmembrane helix predicted by TMHMM2.0 205918020564 Sulfatase; Region: Sulfatase; cl10460 205918020565 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 205918020566 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 205918020567 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 205918020568 C-terminal peptidase (prc); Region: prc; TIGR00225 205918020569 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 205918020570 protein binding site [polypeptide binding]; other site 205918020571 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 205918020572 Catalytic dyad [active] 205918020573 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 205918020574 NodB motif; other site 205918020575 putative active site [active] 205918020576 putative catalytic site [active] 205918020577 Zn binding site [ion binding]; other site 205918020578 Peptidase M60-like family; Region: M60-like; pfam13402 205918020579 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 205918020580 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 205918020581 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918020582 substrate binding pocket [chemical binding]; other site 205918020583 membrane-bound complex binding site; other site 205918020584 hinge residues; other site 205918020585 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 205918020586 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 205918020587 substrate binding site [chemical binding]; other site 205918020588 glutamase interaction surface [polypeptide binding]; other site 205918020589 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 205918020590 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 205918020591 catalytic residues [active] 205918020592 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 205918020593 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 205918020594 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 205918020595 putative active site [active] 205918020596 oxyanion strand; other site 205918020597 catalytic triad [active] 205918020598 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 205918020599 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 205918020600 putative active site pocket [active] 205918020601 4-fold oligomerization interface [polypeptide binding]; other site 205918020602 metal binding residues [ion binding]; metal-binding site 205918020603 3-fold/trimer interface [polypeptide binding]; other site 205918020604 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 205918020605 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918020606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918020607 homodimer interface [polypeptide binding]; other site 205918020608 catalytic residue [active] 205918020609 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 205918020610 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020611 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020612 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020613 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020614 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020615 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020616 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020617 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020618 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020619 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020620 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020621 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020622 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918020623 AsmA family; Region: AsmA; pfam05170 205918020624 AsmA-like C-terminal region; Region: AsmA_2; cl15864 205918020625 1 probable transmembrane helix predicted by TMHMM2.0 205918020626 adenine DNA glycosylase; Provisional; Region: PRK10880 205918020627 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 205918020628 minor groove reading motif; other site 205918020629 helix-hairpin-helix signature motif; other site 205918020630 substrate binding pocket [chemical binding]; other site 205918020631 active site 205918020632 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 205918020633 DNA binding and oxoG recognition site [nucleotide binding] 205918020634 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 205918020635 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 205918020636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918020637 PAS domain; Region: PAS_9; pfam13426 205918020638 putative active site [active] 205918020639 heme pocket [chemical binding]; other site 205918020640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 205918020641 PAS domain; Region: PAS_9; pfam13426 205918020642 putative active site [active] 205918020643 heme pocket [chemical binding]; other site 205918020644 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918020645 dimer interface [polypeptide binding]; other site 205918020646 putative CheW interface [polypeptide binding]; other site 205918020647 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 205918020648 Spore germination protein; Region: Spore_permease; cl15802 205918020649 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020650 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020651 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020652 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020653 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020654 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020655 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020656 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020657 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020658 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020659 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020660 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918020661 Forkhead (FH), also known as a 'winged helix'. FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; Region: FH; cl00061 205918020662 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 205918020663 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918020664 Walker A/P-loop; other site 205918020665 ATP binding site [chemical binding]; other site 205918020666 Q-loop/lid; other site 205918020667 ABC transporter signature motif; other site 205918020668 Walker B; other site 205918020669 D-loop; other site 205918020670 H-loop/switch region; other site 205918020671 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205918020672 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205918020673 substrate binding pocket [chemical binding]; other site 205918020674 membrane-bound complex binding site; other site 205918020675 hinge residues; other site 205918020676 1 probable transmembrane helix predicted by TMHMM2.0 205918020677 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918020678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918020679 dimer interface [polypeptide binding]; other site 205918020680 conserved gate region; other site 205918020681 putative PBP binding loops; other site 205918020682 ABC-ATPase subunit interface; other site 205918020683 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020684 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020685 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020686 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020687 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020688 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205918020689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918020690 dimer interface [polypeptide binding]; other site 205918020691 conserved gate region; other site 205918020692 putative PBP binding loops; other site 205918020693 ABC-ATPase subunit interface; other site 205918020694 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020695 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020696 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918020698 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205918020699 HSP70 interaction site [polypeptide binding]; other site 205918020700 Central core of the bacterial effector protein AvrPto; Region: AvrPto; pfam11592 205918020701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 205918020702 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 205918020703 classical (c) SDRs; Region: SDR_c; cd05233 205918020704 NAD(P) binding site [chemical binding]; other site 205918020705 active site 205918020706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918020707 Helix-turn-helix domains; Region: HTH; cl00088 205918020708 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 205918020709 putative effector binding pocket; other site 205918020710 dimerization interface [polypeptide binding]; other site 205918020711 Uncharacterized conserved protein [Function unknown]; Region: COG4748 205918020712 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 205918020713 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205918020714 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918020715 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 205918020716 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205918020717 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020718 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020719 outer membrane porin, OprD family; Region: OprD; pfam03573 205918020720 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 205918020721 agmatine deiminase; Region: agmatine_aguA; TIGR03380 205918020722 N-carbamolyputrescine amidase; Region: PLN02747 205918020723 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 205918020724 putative active site; other site 205918020725 catalytic triad [active] 205918020726 putative dimer interface [polypeptide binding]; other site 205918020727 hypothetical protein; Provisional; Region: PRK06149 205918020728 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205918020729 active site 205918020730 substrate binding site [chemical binding]; other site 205918020731 ATP binding site [chemical binding]; other site 205918020732 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205918020733 inhibitor-cofactor binding pocket; inhibition site 205918020734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918020735 catalytic residue [active] 205918020736 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 205918020737 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 205918020738 NAD binding site [chemical binding]; other site 205918020739 substrate binding site [chemical binding]; other site 205918020740 homodimer interface [polypeptide binding]; other site 205918020741 active site 205918020742 Cupin domain; Region: Cupin_2; cl09118 205918020743 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 205918020744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918020745 dimer interface [polypeptide binding]; other site 205918020746 phosphorylation site [posttranslational modification] 205918020747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918020748 ATP binding site [chemical binding]; other site 205918020749 Mg2+ binding site [ion binding]; other site 205918020750 G-X-G motif; other site 205918020751 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020752 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020753 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 205918020754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918020755 active site 205918020756 phosphorylation site [posttranslational modification] 205918020757 intermolecular recognition site; other site 205918020758 dimerization interface [polypeptide binding]; other site 205918020759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918020760 Walker A motif; other site 205918020761 ATP binding site [chemical binding]; other site 205918020762 Walker B motif; other site 205918020763 arginine finger; other site 205918020764 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 205918020765 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 205918020766 active site 205918020767 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 205918020768 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 205918020769 dimer interface [polypeptide binding]; other site 205918020770 ADP-ribose binding site [chemical binding]; other site 205918020771 active site 205918020772 nudix motif; other site 205918020773 metal binding site [ion binding]; metal-binding site 205918020774 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 205918020775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918020776 motif II; other site 205918020777 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 205918020778 BON domain; Region: BON; cl02771 205918020779 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205918020780 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 205918020781 Helix-turn-helix domains; Region: HTH; cl00088 205918020782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918020783 dimerization interface [polypeptide binding]; other site 205918020784 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 205918020785 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 205918020786 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 205918020787 putative molybdopterin cofactor binding site [chemical binding]; other site 205918020788 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 205918020789 putative molybdopterin cofactor binding site; other site 205918020790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918020791 ATP binding site [chemical binding]; other site 205918020792 putative Mg++ binding site [ion binding]; other site 205918020793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205918020794 nucleotide binding region [chemical binding]; other site 205918020795 ATP-binding site [chemical binding]; other site 205918020796 1 probable transmembrane helix predicted by TMHMM2.0 205918020797 Peptidase family M48; Region: Peptidase_M48; cl12018 205918020798 Peptidase family M48; Region: Peptidase_M48; cl12018 205918020799 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020800 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020801 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020802 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020803 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020804 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020805 Protein of unknown function (DUF770); Region: DUF770; cl01402 205918020806 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 205918020807 Protein of unknown function (DUF877); Region: DUF877; pfam05943 205918020808 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 205918020809 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 205918020810 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 205918020811 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 205918020812 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 205918020813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918020814 Walker A motif; other site 205918020815 ATP binding site [chemical binding]; other site 205918020816 Walker B motif; other site 205918020817 arginine finger; other site 205918020818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205918020819 Walker A motif; other site 205918020820 ATP binding site [chemical binding]; other site 205918020821 Walker B motif; other site 205918020822 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 205918020823 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 205918020824 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 205918020825 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 205918020826 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 205918020827 1 probable transmembrane helix predicted by TMHMM2.0 205918020828 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 205918020829 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 205918020830 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 205918020831 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 205918020832 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020833 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020834 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020835 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 205918020836 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 205918020837 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 205918020838 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 205918020839 ligand binding site [chemical binding]; other site 205918020840 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020841 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020842 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020843 Protein of unknown function (DUF796); Region: DUF796; cl01226 205918020844 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 205918020845 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 205918020846 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 205918020847 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020848 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020849 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020850 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020851 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020852 PAAR motif; Region: PAAR_motif; cl15808 205918020853 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 205918020854 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 205918020855 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 205918020856 putative active site [active] 205918020857 catalytic site [active] 205918020858 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 205918020859 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 205918020860 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 205918020861 putative active site [active] 205918020862 putative active site [active] 205918020863 catalytic site [active] 205918020864 catalytic site [active] 205918020865 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 205918020866 Sel1 repeat; Region: Sel1; cl02723 205918020867 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 205918020868 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 205918020869 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 205918020870 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 205918020871 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 205918020872 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 205918020873 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020874 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020875 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020876 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020877 1 of 5 probable transmembrane helices predicted by TMHMM2.0 205918020878 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205918020879 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 205918020880 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020881 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020882 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020883 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020884 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020885 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020886 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020887 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020888 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020889 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020890 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020891 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 205918020892 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 205918020893 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 205918020894 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 205918020895 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 205918020896 PAAR motif; Region: PAAR_motif; cl15808 205918020897 RHS Repeat; Region: RHS_repeat; cl11982 205918020898 RHS Repeat; Region: RHS_repeat; cl11982 205918020899 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918020900 RHS protein; Region: RHS; pfam03527 205918020901 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918020902 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020903 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918020904 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 205918020905 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918020906 RHS protein; Region: RHS; pfam03527 205918020907 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918020908 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918020909 RHS Repeat; Region: RHS_repeat; cl11982 205918020910 RHS Repeat; Region: RHS_repeat; cl11982 205918020911 RHS Repeat; Region: RHS_repeat; cl11982 205918020912 RHS protein; Region: RHS; pfam03527 205918020913 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918020914 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 205918020915 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918020916 RHS protein; Region: RHS; pfam03527 205918020917 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918020918 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 205918020919 iron-sulfur cluster [ion binding]; other site 205918020920 [2Fe-2S] cluster binding site [ion binding]; other site 205918020921 RHS protein; Region: RHS; pfam03527 205918020922 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 205918020923 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 205918020924 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020925 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020926 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020927 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020928 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020929 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918020930 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020931 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020932 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020933 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020934 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 205918020935 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020936 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020937 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020938 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205918020939 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 205918020940 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020941 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020942 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020943 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918020944 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205918020945 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020946 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020947 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020948 FIST N domain; Region: FIST; cl10701 205918020949 FIST C domain; Region: FIST_C; pfam10442 205918020950 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918020951 dimer interface [polypeptide binding]; other site 205918020952 putative CheW interface [polypeptide binding]; other site 205918020953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339; cl15420 205918020954 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 205918020955 1 probable transmembrane helix predicted by TMHMM2.0 205918020956 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 205918020957 hydrolase; Region: PLN02811 205918020958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205918020959 motif II; other site 205918020960 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 205918020961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205918020962 active site 205918020963 catalytic tetrad [active] 205918020964 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 205918020965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918020966 DNA-binding site [nucleotide binding]; DNA binding site 205918020967 FCD domain; Region: FCD; cl11656 205918020968 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 205918020969 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 205918020970 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 205918020971 AMP-binding enzyme; Region: AMP-binding; cl15778 205918020972 Phosphopantetheine attachment site; Region: PP-binding; cl09936 205918020973 thioester reductase domain; Region: Thioester-redct; TIGR01746 205918020974 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 205918020975 putative NAD(P) binding site [chemical binding]; other site 205918020976 active site 205918020977 putative substrate binding site [chemical binding]; other site 205918020978 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 205918020979 putative hydrophobic ligand binding site [chemical binding]; other site 205918020980 protein interface [polypeptide binding]; other site 205918020981 gate; other site 205918020982 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 205918020983 CoA-transferase family III; Region: CoA_transf_3; pfam02515 205918020984 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 205918020985 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 205918020986 FAD binding site [chemical binding]; other site 205918020987 substrate binding pocket [chemical binding]; other site 205918020988 catalytic base [active] 205918020989 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 205918020990 Helix-turn-helix domains; Region: HTH; cl00088 205918020991 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 205918020992 dimerization interface [polypeptide binding]; other site 205918020993 substrate binding pocket [chemical binding]; other site 205918020994 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 205918020995 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 205918020996 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 205918020997 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 205918020998 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918020999 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021000 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021001 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 205918021002 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 205918021003 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021004 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021005 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021006 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021007 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021008 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021009 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021010 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021011 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 205918021012 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 205918021013 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 205918021014 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 205918021015 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 205918021016 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 205918021017 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 205918021018 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 205918021019 IHF dimer interface [polypeptide binding]; other site 205918021020 IHF - DNA interface [nucleotide binding]; other site 205918021021 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 205918021022 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205918021023 Rubredoxin [Energy production and conversion]; Region: COG1773 205918021024 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 205918021025 iron binding site [ion binding]; other site 205918021026 UTRA domain; Region: UTRA; cl01230 205918021027 UbiA prenyltransferase family; Region: UbiA; cl00337 205918021028 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021029 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021030 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021031 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021032 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021033 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021034 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021035 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 205918021036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918021037 active site 205918021038 phosphorylation site [posttranslational modification] 205918021039 intermolecular recognition site; other site 205918021040 dimerization interface [polypeptide binding]; other site 205918021041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205918021042 DNA binding site [nucleotide binding] 205918021043 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 205918021044 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 205918021045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 205918021046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918021047 dimer interface [polypeptide binding]; other site 205918021048 phosphorylation site [posttranslational modification] 205918021049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918021050 ATP binding site [chemical binding]; other site 205918021051 Mg2+ binding site [ion binding]; other site 205918021052 G-X-G motif; other site 205918021053 1 probable transmembrane helix predicted by TMHMM2.0 205918021054 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 205918021055 Domain of unknown function DUF21; Region: DUF21; pfam01595 205918021056 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205918021057 Transporter associated domain; Region: CorC_HlyC; cl08393 205918021058 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021059 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021060 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021061 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021062 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 205918021063 Peptidase family M23; Region: Peptidase_M23; pfam01551 205918021064 Response regulator receiver domain; Region: Response_reg; pfam00072 205918021065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918021066 active site 205918021067 phosphorylation site [posttranslational modification] 205918021068 intermolecular recognition site; other site 205918021069 dimerization interface [polypeptide binding]; other site 205918021070 transcriptional regulator PhoU; Provisional; Region: PRK11115 205918021071 PhoU domain; Region: PhoU; pfam01895 205918021072 PhoU domain; Region: PhoU; pfam01895 205918021073 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 205918021074 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 205918021075 Walker A/P-loop; other site 205918021076 ATP binding site [chemical binding]; other site 205918021077 Q-loop/lid; other site 205918021078 ABC transporter signature motif; other site 205918021079 Walker B; other site 205918021080 D-loop; other site 205918021081 H-loop/switch region; other site 205918021082 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 205918021083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918021084 dimer interface [polypeptide binding]; other site 205918021085 conserved gate region; other site 205918021086 putative PBP binding loops; other site 205918021087 ABC-ATPase subunit interface; other site 205918021088 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021089 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021090 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021091 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021092 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021093 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021094 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 205918021095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918021096 dimer interface [polypeptide binding]; other site 205918021097 conserved gate region; other site 205918021098 putative PBP binding loops; other site 205918021099 ABC-ATPase subunit interface; other site 205918021100 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021101 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021102 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021103 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021104 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021105 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021106 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021107 1 of 8 probable transmembrane helices predicted by TMHMM2.0 205918021108 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205918021109 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 205918021110 metabolite-proton symporter; Region: 2A0106; TIGR00883 205918021111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205918021112 putative substrate translocation pore; other site 205918021113 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021114 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021115 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021116 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021117 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021118 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021119 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021120 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021121 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021122 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021123 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021124 1 of 12 probable transmembrane helices predicted by TMHMM2.0 205918021125 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 205918021126 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 205918021127 active site 205918021128 phosphate binding residues; other site 205918021129 catalytic residues [active] 205918021130 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 205918021131 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 205918021132 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021133 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021134 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021135 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 205918021136 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918021137 AIR carboxylase; Region: AIRC; cl00310 205918021138 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 205918021139 1 probable transmembrane helix predicted by TMHMM2.0 205918021140 cell density-dependent motility repressor; Provisional; Region: PRK10082 205918021141 Helix-turn-helix domains; Region: HTH; cl00088 205918021142 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205918021143 dimerization interface [polypeptide binding]; other site 205918021144 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 205918021145 Aspartase; Region: Aspartase; cd01357 205918021146 active sites [active] 205918021147 tetramer interface [polypeptide binding]; other site 205918021148 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 205918021149 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 205918021150 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021151 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021152 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021153 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021154 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021155 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021156 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021157 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021158 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021159 1 of 10 probable transmembrane helices predicted by TMHMM2.0 205918021160 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 205918021161 active site 205918021162 homodimer interface [polypeptide binding]; other site 205918021163 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 205918021164 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021165 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021166 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021167 putative inner membrane protein; Provisional; Region: PRK11099 205918021168 Sulphur transport; Region: Sulf_transp; cl01018 205918021169 putative inner membrane protein; Provisional; Region: PRK11099 205918021170 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021171 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021172 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021173 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021174 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021175 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021176 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021177 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021178 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021179 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021180 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021181 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 205918021182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205918021183 DNA-binding site [nucleotide binding]; DNA binding site 205918021184 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205918021185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205918021186 homodimer interface [polypeptide binding]; other site 205918021187 catalytic residue [active] 205918021188 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 205918021189 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205918021190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205918021191 Coenzyme A binding pocket [chemical binding]; other site 205918021192 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 205918021193 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918021194 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205918021195 pyruvate carboxylase subunit B; Validated; Region: PRK09282 205918021196 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 205918021197 active site 205918021198 catalytic residues [active] 205918021199 metal binding site [ion binding]; metal-binding site 205918021200 homodimer binding site [polypeptide binding]; other site 205918021201 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 205918021202 carboxyltransferase (CT) interaction site; other site 205918021203 biotinylation site [posttranslational modification]; other site 205918021204 pyruvate carboxylase subunit A; Validated; Region: PRK07178 205918021205 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205918021206 ATP-grasp domain; Region: ATP-grasp_4; cl03087 205918021207 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 205918021208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205918021209 Helix-turn-helix domains; Region: HTH; cl00088 205918021210 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 205918021211 putative dimerization interface [polypeptide binding]; other site 205918021212 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 205918021213 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 205918021214 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 205918021215 putative active site [active] 205918021216 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 205918021217 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918021218 Family description; Region: UvrD_C_2; cl15862 205918021219 Tim44-like domain; Region: Tim44; cl09208 205918021220 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021221 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021222 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 205918021223 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 205918021224 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 205918021225 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021226 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021227 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021228 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021229 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021230 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021231 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021232 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021233 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021234 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021235 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021236 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021237 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021238 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021239 1 of 15 probable transmembrane helices predicted by TMHMM2.0 205918021240 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 205918021241 pyridoxamine kinase; Validated; Region: PRK05756 205918021242 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 205918021243 pyridoxal binding site [chemical binding]; other site 205918021244 dimer interface [polypeptide binding]; other site 205918021245 ATP binding site [chemical binding]; other site 205918021246 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 205918021247 1 probable transmembrane helix predicted by TMHMM2.0 205918021248 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 205918021249 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918021250 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 205918021251 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 205918021252 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 205918021253 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918021254 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 205918021255 AMIN domain; Region: AMIN; pfam11741 205918021256 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 205918021257 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 205918021258 active site 205918021259 metal binding site [ion binding]; metal-binding site 205918021260 1 probable transmembrane helix predicted by TMHMM2.0 205918021261 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 205918021262 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 205918021263 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 205918021264 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 205918021265 putative active site [active] 205918021266 catalytic site [active] 205918021267 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 205918021268 putative active site [active] 205918021269 catalytic site [active] 205918021270 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021271 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021272 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 205918021273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918021274 S-adenosylmethionine binding site [chemical binding]; other site 205918021275 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 205918021276 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205918021277 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021278 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021279 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021280 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021281 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021282 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021283 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021284 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 205918021285 HflK protein; Region: hflK; TIGR01933 205918021286 1 probable transmembrane helix predicted by TMHMM2.0 205918021287 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 205918021288 HflC protein; Region: hflC; TIGR01932 205918021289 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 205918021290 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 205918021291 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021292 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021293 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021294 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021295 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021296 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021297 1 of 7 probable transmembrane helices predicted by TMHMM2.0 205918021298 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 205918021299 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 205918021300 1 probable transmembrane helix predicted by TMHMM2.0 205918021301 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021302 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021303 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021304 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021305 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021306 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021307 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021308 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021309 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021310 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021311 1 of 11 probable transmembrane helices predicted by TMHMM2.0 205918021312 OpgC protein; Region: OpgC_C; cl00792 205918021313 Acyltransferase family; Region: Acyl_transf_3; pfam01757 205918021314 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021315 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021316 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021317 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021318 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021319 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021320 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021321 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021322 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021323 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 205918021324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205918021325 active site 205918021326 phosphorylation site [posttranslational modification] 205918021327 intermolecular recognition site; other site 205918021328 dimerization interface [polypeptide binding]; other site 205918021329 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205918021330 dimerization interface [polypeptide binding]; other site 205918021331 DNA binding residues [nucleotide binding] 205918021332 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205918021333 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205918021334 dimer interface [polypeptide binding]; other site 205918021335 phosphorylation site [posttranslational modification] 205918021336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205918021337 ATP binding site [chemical binding]; other site 205918021338 Mg2+ binding site [ion binding]; other site 205918021339 G-X-G motif; other site 205918021340 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021341 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021342 1 of 3 probable transmembrane helices predicted by TMHMM2.0 205918021343 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 205918021344 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 205918021345 Walker A/P-loop; other site 205918021346 ATP binding site [chemical binding]; other site 205918021347 Q-loop/lid; other site 205918021348 ABC transporter signature motif; other site 205918021349 Walker B; other site 205918021350 D-loop; other site 205918021351 H-loop/switch region; other site 205918021352 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 205918021353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 205918021354 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 205918021355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205918021356 dimer interface [polypeptide binding]; other site 205918021357 conserved gate region; other site 205918021358 putative PBP binding loops; other site 205918021359 ABC-ATPase subunit interface; other site 205918021360 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021361 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021362 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021363 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021364 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021365 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021366 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021367 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021368 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021369 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021370 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021371 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021372 1 of 13 probable transmembrane helices predicted by TMHMM2.0 205918021373 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 205918021374 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918021375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205918021376 dimerization interface [polypeptide binding]; other site 205918021377 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918021378 dimer interface [polypeptide binding]; other site 205918021379 putative CheW interface [polypeptide binding]; other site 205918021380 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021381 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021382 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 205918021383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 205918021384 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 205918021385 dimer interface [polypeptide binding]; other site 205918021386 putative CheW interface [polypeptide binding]; other site 205918021387 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021388 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021389 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 205918021390 dimanganese center [ion binding]; other site 205918021391 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 205918021392 dimerization interface [polypeptide binding]; other site 205918021393 metal binding site [ion binding]; metal-binding site 205918021394 Domain of unknown function (DUF305); Region: DUF305; cl15795 205918021395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205918021396 S-adenosylmethionine binding site [chemical binding]; other site 205918021397 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 205918021398 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 205918021399 putative metal binding site [ion binding]; other site 205918021400 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 205918021401 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 205918021402 Walker A/P-loop; other site 205918021403 ATP binding site [chemical binding]; other site 205918021404 Q-loop/lid; other site 205918021405 ABC transporter signature motif; other site 205918021406 Walker B; other site 205918021407 D-loop; other site 205918021408 H-loop/switch region; other site 205918021409 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 205918021410 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 205918021411 putative ligand binding residues [chemical binding]; other site 205918021412 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205918021413 ABC-ATPase subunit interface; other site 205918021414 dimer interface [polypeptide binding]; other site 205918021415 putative PBP binding regions; other site 205918021416 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021417 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021418 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021419 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021420 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021421 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021422 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021423 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021424 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021425 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 205918021426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918021427 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 205918021428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918021429 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 205918021430 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 205918021431 putative NAD(P) binding site [chemical binding]; other site 205918021432 active site 205918021433 putative substrate binding site [chemical binding]; other site 205918021434 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 205918021435 Ligand binding site; other site 205918021436 Putative Catalytic site; other site 205918021437 DXD motif; other site 205918021438 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 205918021439 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021440 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021441 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 205918021442 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021443 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021444 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021445 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021446 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021447 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021448 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021449 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021450 1 of 9 probable transmembrane helices predicted by TMHMM2.0 205918021451 SdiA-regulated; Region: SdiA-regulated; pfam06977 205918021452 SdiA-regulated; Region: SdiA-regulated; cd09971 205918021453 putative active site [active] 205918021454 1 probable transmembrane helix predicted by TMHMM2.0 205918021455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918021456 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 205918021457 NAD(P) binding site [chemical binding]; other site 205918021458 active site 205918021459 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 205918021460 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 205918021461 tetramer interface [polypeptide binding]; other site 205918021462 active site 205918021463 Mg2+/Mn2+ binding site [ion binding]; other site 205918021464 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205918021465 ATP binding site [chemical binding]; other site 205918021466 putative Mg++ binding site [ion binding]; other site 205918021467 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 205918021468 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 205918021469 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 205918021470 glutaminase active site [active] 205918021471 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 205918021472 dimer interface [polypeptide binding]; other site 205918021473 active site 205918021474 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 205918021475 dimer interface [polypeptide binding]; other site 205918021476 active site 205918021477 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 205918021478 Helix-turn-helix domains; Region: HTH; cl00088 205918021479 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 205918021480 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 205918021481 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 205918021482 Substrate binding site; other site 205918021483 Mg++ binding site; other site 205918021484 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 205918021485 active site 205918021486 substrate binding site [chemical binding]; other site 205918021487 CoA binding site [chemical binding]; other site 205918021488 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 205918021489 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 205918021490 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 205918021491 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 205918021492 alpha subunit interaction interface [polypeptide binding]; other site 205918021493 Walker A motif; other site 205918021494 ATP binding site [chemical binding]; other site 205918021495 Walker B motif; other site 205918021496 inhibitor binding site; inhibition site 205918021497 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 205918021498 ATP synthase; Region: ATP-synt; cl00365 205918021499 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 205918021500 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 205918021501 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 205918021502 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 205918021503 beta subunit interaction interface [polypeptide binding]; other site 205918021504 Walker A motif; other site 205918021505 ATP binding site [chemical binding]; other site 205918021506 Walker B motif; other site 205918021507 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 205918021508 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 205918021509 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 205918021510 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 205918021511 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 205918021512 1 probable transmembrane helix predicted by TMHMM2.0 205918021513 ATP synthase subunit C; Region: ATP-synt_C; cl00466 205918021514 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021515 1 of 2 probable transmembrane helices predicted by TMHMM2.0 205918021516 ATP synthase A chain; Region: ATP-synt_A; cl00413 205918021517 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021518 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021519 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021520 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021521 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021522 1 of 6 probable transmembrane helices predicted by TMHMM2.0 205918021523 ATP synthase I chain; Region: ATP_synt_I; cl09170 205918021524 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021525 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021526 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021527 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021528 ParB-like partition proteins; Region: parB_part; TIGR00180 205918021529 ParB-like nuclease domain; Region: ParBc; cl02129 205918021530 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205918021531 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918021532 P-loop; other site 205918021533 Magnesium ion binding site [ion binding]; other site 205918021534 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205918021535 Magnesium ion binding site [ion binding]; other site 205918021536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 205918021537 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 205918021538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918021539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205918021540 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 205918021541 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 205918021542 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 205918021543 trmE is a tRNA modification GTPase; Region: trmE; cd04164 205918021544 G1 box; other site 205918021545 GTP/Mg2+ binding site [chemical binding]; other site 205918021546 Switch I region; other site 205918021547 G2 box; other site 205918021548 Switch II region; other site 205918021549 G3 box; other site 205918021550 G4 box; other site 205918021551 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 205918021552 membrane protein insertase; Provisional; Region: PRK01318 205918021553 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 205918021554 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021555 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021556 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021557 1 of 4 probable transmembrane helices predicted by TMHMM2.0 205918021558 Haemolytic domain; Region: Haemolytic; cl00506 205918021559 Ribonuclease P; Region: Ribonuclease_P; cl00457 205918021560 Ribosomal protein L34; Region: Ribosomal_L34; cl00370