-- dump date 20120504_155710 -- class Genbank::misc_feature -- table misc_feature_note -- id note 675635000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 675635000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635000003 Walker A motif; other site 675635000004 ATP binding site [chemical binding]; other site 675635000005 Walker B motif; other site 675635000006 arginine finger; other site 675635000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 675635000008 DnaA box-binding interface [nucleotide binding]; other site 675635000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 675635000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 675635000011 putative DNA binding surface [nucleotide binding]; other site 675635000012 dimer interface [polypeptide binding]; other site 675635000013 beta-clamp/clamp loader binding surface; other site 675635000014 beta-clamp/translesion DNA polymerase binding surface; other site 675635000015 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 675635000016 Walker A/P-loop; other site 675635000017 ATP binding site [chemical binding]; other site 675635000018 Q-loop/lid; other site 675635000019 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635000020 ABC transporter signature motif; other site 675635000021 Walker B; other site 675635000022 Protein of unknown function (DUF721); Region: DUF721; cl02324 675635000023 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 675635000024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635000025 Mg2+ binding site [ion binding]; other site 675635000026 G-X-G motif; other site 675635000027 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 675635000028 anchoring element; other site 675635000029 dimer interface [polypeptide binding]; other site 675635000030 ATP binding site [chemical binding]; other site 675635000031 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 675635000032 active site 675635000033 putative metal-binding site [ion binding]; other site 675635000034 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 675635000035 DNA gyrase subunit A; Validated; Region: PRK05560 675635000036 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 675635000037 CAP-like domain; other site 675635000038 active site 675635000039 primary dimer interface [polypeptide binding]; other site 675635000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 675635000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 675635000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 675635000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 675635000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 675635000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 675635000046 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 675635000047 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635000048 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635000049 active site 675635000050 Int/Topo IB signature motif; other site 675635000051 DNA binding site [nucleotide binding] 675635000052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635000053 Transposase domain (DUF772); Region: DUF772; cl15789 675635000054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635000055 Integrase core domain; Region: rve; cl01316 675635000056 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 675635000057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635000058 Walker A motif; other site 675635000059 ATP binding site [chemical binding]; other site 675635000060 Walker B motif; other site 675635000061 arginine finger; other site 675635000062 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635000063 MULE transposase domain; Region: MULE; pfam10551 675635000064 Isochorismatase family; Region: Isochorismatase; pfam00857 675635000065 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 675635000066 catalytic triad [active] 675635000067 conserved cis-peptide bond; other site 675635000068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635000069 DNA-binding site [nucleotide binding]; DNA binding site 675635000070 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635000071 transposase/IS protein; Provisional; Region: PRK09183 675635000072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635000073 Walker A motif; other site 675635000074 ATP binding site [chemical binding]; other site 675635000075 Walker B motif; other site 675635000076 arginine finger; other site 675635000077 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635000078 Integrase core domain; Region: rve; cl01316 675635000079 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635000080 Walker A motif; other site 675635000081 ATP binding site [chemical binding]; other site 675635000082 Walker B motif; other site 675635000083 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 675635000084 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635000085 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 675635000086 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 675635000087 putative active site [active] 675635000088 putative NTP binding site [chemical binding]; other site 675635000089 putative nucleic acid binding site [nucleotide binding]; other site 675635000090 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 675635000091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635000092 dimerization interface [polypeptide binding]; other site 675635000093 putative DNA binding site [nucleotide binding]; other site 675635000094 putative Zn2+ binding site [ion binding]; other site 675635000095 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 675635000096 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635000097 MgtE intracellular N domain; Region: MgtE_N; cl15244 675635000098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 675635000099 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 675635000100 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 675635000101 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 675635000102 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 675635000103 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 675635000104 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 675635000105 catalytic triad [active] 675635000106 DDE superfamily endonuclease; Region: DDE_5; cl02413 675635000107 DDE superfamily endonuclease; Region: DDE_5; cl02413 675635000108 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635000109 MULE transposase domain; Region: MULE; pfam10551 675635000110 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 675635000111 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 675635000112 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 675635000113 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 675635000114 AMP-binding domain protein; Validated; Region: PRK08315 675635000115 AMP-binding enzyme; Region: AMP-binding; cl15778 675635000116 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 675635000117 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635000118 putative trimer interface [polypeptide binding]; other site 675635000119 putative CoA binding site [chemical binding]; other site 675635000120 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 675635000121 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635000122 putative trimer interface [polypeptide binding]; other site 675635000123 putative CoA binding site [chemical binding]; other site 675635000124 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 675635000125 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 675635000126 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 675635000127 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 675635000128 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 675635000129 Winged helix-turn helix; Region: HTH_29; pfam13551 675635000130 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635000131 Helix-turn-helix domains; Region: HTH; cl00088 675635000132 Integrase core domain; Region: rve; cl01316 675635000133 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635000134 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635000135 FAD binding domain; Region: FAD_binding_4; pfam01565 675635000136 Helix-turn-helix domains; Region: HTH; cl00088 675635000137 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 675635000138 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635000139 Predicted ATPase [General function prediction only]; Region: COG3903 675635000140 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 675635000141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000142 hypothetical protein; Provisional; Region: PRK06184 675635000143 Helix-turn-helix domains; Region: HTH; cl00088 675635000144 Low molecular weight phosphatase family; Region: LMWPc; cd00115 675635000145 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 675635000146 active site 675635000147 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635000148 active site 675635000149 metal binding site [ion binding]; metal-binding site 675635000150 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635000151 benzoate transport; Region: 2A0115; TIGR00895 675635000152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635000153 putative substrate translocation pore; other site 675635000154 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635000155 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635000156 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 675635000157 catalytic loop [active] 675635000158 iron binding site [ion binding]; other site 675635000159 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 675635000160 FAD binding pocket [chemical binding]; other site 675635000161 FAD binding motif [chemical binding]; other site 675635000162 phosphate binding motif [ion binding]; other site 675635000163 beta-alpha-beta structure motif; other site 675635000164 NAD binding pocket [chemical binding]; other site 675635000165 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 675635000166 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 675635000167 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 675635000168 inter-subunit interface; other site 675635000169 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 675635000170 Helix-turn-helix domains; Region: HTH; cl00088 675635000171 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635000172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635000173 S-adenosylmethionine binding site [chemical binding]; other site 675635000174 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 675635000175 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635000176 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635000177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635000178 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635000179 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635000180 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635000181 Walker A/P-loop; other site 675635000182 ATP binding site [chemical binding]; other site 675635000183 Q-loop/lid; other site 675635000184 ABC transporter signature motif; other site 675635000185 Walker B; other site 675635000186 D-loop; other site 675635000187 H-loop/switch region; other site 675635000188 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635000189 Walker A/P-loop; other site 675635000190 ATP binding site [chemical binding]; other site 675635000191 Q-loop/lid; other site 675635000192 ABC transporter signature motif; other site 675635000193 Walker B; other site 675635000194 D-loop; other site 675635000195 H-loop/switch region; other site 675635000196 LysE type translocator; Region: LysE; cl00565 675635000197 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635000198 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635000199 putative DNA binding site [nucleotide binding]; other site 675635000200 putative Zn2+ binding site [ion binding]; other site 675635000201 Helix-turn-helix domains; Region: HTH; cl00088 675635000202 CheB methylesterase; Region: CheB_methylest; pfam01339 675635000203 ANTAR domain; Region: ANTAR; cl04297 675635000204 Protein of unknown function, DUF485; Region: DUF485; cl01231 675635000205 Sodium:solute symporter family; Region: SSF; cl00456 675635000206 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 675635000207 HEAT repeats; Region: HEAT_2; pfam13646 675635000208 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 675635000209 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635000210 DNA binding residues [nucleotide binding] 675635000211 putative dimer interface [polypeptide binding]; other site 675635000212 HEAT repeats; Region: HEAT_2; pfam13646 675635000213 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635000214 YCII-related domain; Region: YCII; cl00999 675635000215 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 675635000216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635000217 Predicted membrane protein [Function unknown]; Region: COG2860 675635000218 UPF0126 domain; Region: UPF0126; pfam03458 675635000219 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 675635000220 transcriptional regulator NanR; Provisional; Region: PRK03837 675635000221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635000222 DNA-binding site [nucleotide binding]; DNA binding site 675635000223 FCD domain; Region: FCD; cl11656 675635000224 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 675635000225 putative active site [active] 675635000226 putative catalytic site [active] 675635000227 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 675635000228 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635000229 catalytic Zn binding site [ion binding]; other site 675635000230 structural Zn binding site [ion binding]; other site 675635000231 tetramer interface [polypeptide binding]; other site 675635000232 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 675635000233 MT-A70; Region: MT-A70; cl01947 675635000234 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635000235 WYL domain; Region: WYL; cl14852 675635000236 FAD binding domain; Region: FAD_binding_4; pfam01565 675635000237 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635000238 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635000239 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 675635000240 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 675635000241 active site 675635000242 Rhomboid family; Region: Rhomboid; cl11446 675635000243 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 675635000244 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 675635000245 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 675635000246 Glutamine amidotransferase class-I; Region: GATase; pfam00117 675635000247 glutamine binding [chemical binding]; other site 675635000248 catalytic triad [active] 675635000249 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635000250 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635000251 active site 675635000252 ATP binding site [chemical binding]; other site 675635000253 substrate binding site [chemical binding]; other site 675635000254 activation loop (A-loop); other site 675635000255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 675635000256 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635000257 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635000258 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635000259 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 675635000260 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635000261 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635000262 active site 675635000263 ATP binding site [chemical binding]; other site 675635000264 substrate binding site [chemical binding]; other site 675635000265 activation loop (A-loop); other site 675635000266 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 675635000267 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 675635000268 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635000269 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 675635000270 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 675635000271 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 675635000272 active site 675635000273 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 675635000274 phosphopeptide binding site; other site 675635000275 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 675635000276 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 675635000277 phosphopeptide binding site; other site 675635000278 uridine kinase; Validated; Region: PRK06696 675635000279 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 675635000280 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635000281 Helix-turn-helix domains; Region: HTH; cl00088 675635000282 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635000283 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635000284 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 675635000285 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635000286 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 675635000287 substrate binding site [chemical binding]; other site 675635000288 THF binding site; other site 675635000289 zinc-binding site [ion binding]; other site 675635000290 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 675635000291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635000292 motif II; other site 675635000293 Domain of unknown function DUF59; Region: DUF59; cl00941 675635000294 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 675635000295 active site 675635000296 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 675635000297 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 675635000298 NAD binding site [chemical binding]; other site 675635000299 substrate binding site [chemical binding]; other site 675635000300 catalytic Zn binding site [ion binding]; other site 675635000301 structural Zn binding site [ion binding]; other site 675635000302 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635000303 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 675635000304 AMP-binding enzyme; Region: AMP-binding; cl15778 675635000305 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 675635000306 CoenzymeA binding site [chemical binding]; other site 675635000307 subunit interaction site [polypeptide binding]; other site 675635000308 PHB binding site; other site 675635000309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000310 NAD(P) binding site [chemical binding]; other site 675635000311 active site 675635000312 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 675635000313 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635000314 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635000315 Copper resistance protein D; Region: CopD; cl00563 675635000316 Bacterial Ig-like domain; Region: Big_5; cl01012 675635000317 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 675635000318 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 675635000319 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 675635000320 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 675635000321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000322 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 675635000323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000324 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 675635000325 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 675635000326 active site 675635000327 DNA binding site [nucleotide binding] 675635000328 YceI-like domain; Region: YceI; cl01001 675635000329 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635000330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635000331 putative substrate translocation pore; other site 675635000332 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635000333 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635000334 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635000335 Helix-turn-helix domains; Region: HTH; cl00088 675635000336 Cupin domain; Region: Cupin_2; cl09118 675635000337 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 675635000338 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 675635000339 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 675635000340 putative DNA binding site [nucleotide binding]; other site 675635000341 catalytic residue [active] 675635000342 putative H2TH interface [polypeptide binding]; other site 675635000343 putative catalytic residues [active] 675635000344 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 675635000345 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 675635000346 Histidine kinase; Region: His_kinase; pfam06580 675635000347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635000348 ATP binding site [chemical binding]; other site 675635000349 Mg2+ binding site [ion binding]; other site 675635000350 G-X-G motif; other site 675635000351 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 675635000352 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 675635000353 tandem repeat interface [polypeptide binding]; other site 675635000354 oligomer interface [polypeptide binding]; other site 675635000355 active site residues [active] 675635000356 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 675635000357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635000358 active site 675635000359 phosphorylation site [posttranslational modification] 675635000360 intermolecular recognition site; other site 675635000361 dimerization interface [polypeptide binding]; other site 675635000362 LytTr DNA-binding domain; Region: LytTR; cl04498 675635000363 Sodium:solute symporter family; Region: SSF; cl00456 675635000364 Sodium:solute symporter family; Region: SSF; cl00456 675635000365 Sodium:solute symporter family; Region: SSF; cl00456 675635000366 Sodium:solute symporter family; Region: SSF; cl00456 675635000367 Sodium:solute symporter family; Region: SSF; cl00456 675635000368 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635000369 active site residue [active] 675635000370 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 675635000371 SEC-C motif; Region: SEC-C; pfam02810 675635000372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000373 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 675635000374 NAD(P) binding site [chemical binding]; other site 675635000375 active site 675635000376 CAAX protease self-immunity; Region: Abi; cl00558 675635000377 Glucitol operon activator protein (GutM); Region: GutM; cl01890 675635000378 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 675635000379 prephenate dehydratase; Provisional; Region: PRK11898 675635000380 Prephenate dehydratase; Region: PDT; pfam00800 675635000381 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 675635000382 putative L-Phe binding site [chemical binding]; other site 675635000383 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635000384 catalytic core [active] 675635000385 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 675635000386 Septum formation; Region: Septum_form; pfam13845 675635000387 Septum formation; Region: Septum_form; pfam13845 675635000388 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 675635000389 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 675635000390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635000391 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 675635000392 active site 675635000393 motif I; other site 675635000394 motif II; other site 675635000395 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635000396 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635000397 UbiA prenyltransferase family; Region: UbiA; cl00337 675635000398 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 675635000399 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 675635000400 substrate binding site; other site 675635000401 tetramer interface; other site 675635000402 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 675635000403 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 675635000404 NAD binding site [chemical binding]; other site 675635000405 substrate binding site [chemical binding]; other site 675635000406 homodimer interface [polypeptide binding]; other site 675635000407 active site 675635000408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000409 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 675635000410 Ligand binding site; other site 675635000411 Putative Catalytic site; other site 675635000412 DXD motif; other site 675635000413 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 675635000414 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 675635000415 Probable Catalytic site; other site 675635000416 metal-binding site 675635000417 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 675635000418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000419 UDP-galactopyranose mutase; Region: GLF; pfam03275 675635000420 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 675635000421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635000422 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635000423 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 675635000424 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635000425 active site 675635000426 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635000427 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 675635000428 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 675635000429 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 675635000430 OpgC protein; Region: OpgC_C; cl00792 675635000431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000432 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 675635000433 FMN binding site [chemical binding]; other site 675635000434 dimer interface [polypeptide binding]; other site 675635000435 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 675635000436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000437 NAD(P) binding site [chemical binding]; other site 675635000438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000439 active site 675635000440 active site 675635000441 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635000442 FAD binding domain; Region: FAD_binding_4; pfam01565 675635000443 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 675635000444 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635000445 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 675635000446 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 675635000447 Walker A/P-loop; other site 675635000448 ATP binding site [chemical binding]; other site 675635000449 Q-loop/lid; other site 675635000450 ABC transporter signature motif; other site 675635000451 Walker B; other site 675635000452 D-loop; other site 675635000453 H-loop/switch region; other site 675635000454 Helix-turn-helix domains; Region: HTH; cl00088 675635000455 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635000456 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635000457 DNA binding residues [nucleotide binding] 675635000458 dimerization interface [polypeptide binding]; other site 675635000459 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 675635000460 GtrA-like protein; Region: GtrA; cl00971 675635000461 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635000462 active site 675635000463 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 675635000464 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 675635000465 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 675635000466 Walker A/P-loop; other site 675635000467 ATP binding site [chemical binding]; other site 675635000468 Q-loop/lid; other site 675635000469 ABC transporter signature motif; other site 675635000470 Walker B; other site 675635000471 D-loop; other site 675635000472 H-loop/switch region; other site 675635000473 ABC-2 type transporter; Region: ABC2_membrane; cl11417 675635000474 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 675635000475 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 675635000476 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 675635000477 NAD(P) binding site [chemical binding]; other site 675635000478 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 675635000479 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635000480 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 675635000481 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635000482 Helix-turn-helix domains; Region: HTH; cl00088 675635000483 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 675635000484 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635000485 Flavin Reductases; Region: FlaRed; cl00801 675635000486 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 675635000487 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635000488 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 675635000489 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 675635000490 active site 675635000491 metal binding site [ion binding]; metal-binding site 675635000492 Cupin domain; Region: Cupin_2; cl09118 675635000493 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635000494 classical (c) SDRs; Region: SDR_c; cd05233 675635000495 NAD(P) binding site [chemical binding]; other site 675635000496 active site 675635000497 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635000498 GAF domain; Region: GAF_2; pfam13185 675635000499 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 675635000500 Helix-turn-helix domains; Region: HTH; cl00088 675635000501 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635000502 Helix-turn-helix domains; Region: HTH; cl00088 675635000503 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 675635000504 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635000505 putative NAD(P) binding site [chemical binding]; other site 675635000506 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 675635000507 active site 675635000508 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 675635000509 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 675635000510 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 675635000511 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 675635000512 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 675635000513 active site 675635000514 metal binding site [ion binding]; metal-binding site 675635000515 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 675635000516 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 675635000517 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 675635000518 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 675635000519 active site 675635000520 Zn binding site [ion binding]; other site 675635000521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 675635000522 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 675635000523 active site 675635000524 phosphorylation site [posttranslational modification] 675635000525 intermolecular recognition site; other site 675635000526 dimerization interface [polypeptide binding]; other site 675635000527 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635000528 DNA binding site [nucleotide binding] 675635000529 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 675635000530 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635000531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635000532 homodimer interface [polypeptide binding]; other site 675635000533 catalytic residue [active] 675635000534 Dienelactone hydrolase family; Region: DLH; pfam01738 675635000535 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 675635000536 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 675635000537 AMP-binding enzyme; Region: AMP-binding; cl15778 675635000538 NmrA-like family; Region: NmrA; pfam05368 675635000539 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 675635000540 NADP binding site [chemical binding]; other site 675635000541 active site 675635000542 regulatory binding site [polypeptide binding]; other site 675635000543 Helix-turn-helix domains; Region: HTH; cl00088 675635000544 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 675635000545 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 675635000546 DsrE/DsrF-like family; Region: DrsE; cl00672 675635000547 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635000548 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 675635000549 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 675635000550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 675635000551 Zn2+ binding site [ion binding]; other site 675635000552 Mg2+ binding site [ion binding]; other site 675635000553 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635000554 DNA binding residues [nucleotide binding] 675635000555 dimerization interface [polypeptide binding]; other site 675635000556 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 675635000557 putative active site [active] 675635000558 metal binding site [ion binding]; metal-binding site 675635000559 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 675635000560 ABC-ATPase subunit interface; other site 675635000561 dimer interface [polypeptide binding]; other site 675635000562 putative PBP binding regions; other site 675635000563 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 675635000564 ABC-ATPase subunit interface; other site 675635000565 dimer interface [polypeptide binding]; other site 675635000566 putative PBP binding regions; other site 675635000567 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 675635000568 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 675635000569 intersubunit interface [polypeptide binding]; other site 675635000570 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 675635000571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000572 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635000573 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635000574 Walker A/P-loop; other site 675635000575 ATP binding site [chemical binding]; other site 675635000576 Q-loop/lid; other site 675635000577 ABC transporter signature motif; other site 675635000578 Walker B; other site 675635000579 D-loop; other site 675635000580 H-loop/switch region; other site 675635000581 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635000582 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 675635000583 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635000584 Walker A/P-loop; other site 675635000585 ATP binding site [chemical binding]; other site 675635000586 Q-loop/lid; other site 675635000587 ABC transporter signature motif; other site 675635000588 Walker B; other site 675635000589 D-loop; other site 675635000590 H-loop/switch region; other site 675635000591 peptide synthase; Provisional; Region: PRK12467 675635000592 AMP-binding enzyme; Region: AMP-binding; cl15778 675635000593 Phosphopantetheine attachment site; Region: PP-binding; cl09936 675635000594 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 675635000595 AMP-binding enzyme; Region: AMP-binding; cl15778 675635000596 Phosphopantetheine attachment site; Region: PP-binding; cl09936 675635000597 Condensation domain; Region: Condensation; pfam00668 675635000598 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 675635000599 peptide synthase; Provisional; Region: PRK12467 675635000600 AMP-binding enzyme; Region: AMP-binding; cl15778 675635000601 Phosphopantetheine attachment site; Region: PP-binding; cl09936 675635000602 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 675635000603 peptide synthase; Provisional; Region: PRK12316 675635000604 AMP-binding enzyme; Region: AMP-binding; cl15778 675635000605 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 675635000606 AMP-binding enzyme; Region: AMP-binding; cl15778 675635000607 Phosphopantetheine attachment site; Region: PP-binding; cl09936 675635000608 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 675635000609 AMP-binding enzyme; Region: AMP-binding; cl15778 675635000610 Phosphopantetheine attachment site; Region: PP-binding; cl09936 675635000611 Thioesterase domain; Region: Thioesterase; pfam00975 675635000612 hypothetical protein; Provisional; Region: PRK06834 675635000613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000615 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635000616 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 675635000617 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635000618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635000619 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 675635000620 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 675635000621 MOSC domain; Region: MOSC; pfam03473 675635000622 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 675635000623 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635000624 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635000625 Dimerisation domain; Region: Dimerisation; pfam08100 675635000626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 675635000627 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 675635000628 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635000629 active site 675635000630 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635000631 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635000632 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635000633 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635000634 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635000635 Helix-turn-helix domains; Region: HTH; cl00088 675635000636 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635000637 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 675635000638 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 675635000639 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 675635000640 YCII-related domain; Region: YCII; cl00999 675635000641 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635000642 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635000643 active site 675635000644 non-prolyl cis peptide bond; other site 675635000645 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635000646 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635000647 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635000648 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635000649 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635000650 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635000651 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635000652 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 675635000653 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635000654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635000655 putative substrate translocation pore; other site 675635000656 hypothetical protein; Provisional; Region: PRK06184 675635000657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000658 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 675635000659 catalytic triad [active] 675635000660 dimer interface [polypeptide binding]; other site 675635000661 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 675635000662 motif 1; other site 675635000663 active site 675635000664 motif 2; other site 675635000665 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 675635000666 motif 3; other site 675635000667 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 675635000668 Predicted esterase [General function prediction only]; Region: COG0627 675635000669 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 675635000670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635000671 putative metal binding site [ion binding]; other site 675635000672 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635000673 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635000674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000675 NAD(P) binding site [chemical binding]; other site 675635000676 active site 675635000677 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 675635000678 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635000679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000680 NAD(P) binding site [chemical binding]; other site 675635000681 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 675635000682 DNA binding site [nucleotide binding] 675635000683 active site 675635000684 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 675635000685 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 675635000686 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635000687 DNA binding residues [nucleotide binding] 675635000688 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635000689 acyl-CoA synthetase; Validated; Region: PRK07787 675635000690 AMP-binding enzyme; Region: AMP-binding; cl15778 675635000691 AMP-binding enzyme; Region: AMP-binding; cl15778 675635000692 enoyl-CoA hydratase; Provisional; Region: PRK06127 675635000693 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635000694 substrate binding site [chemical binding]; other site 675635000695 oxyanion hole (OAH) forming residues; other site 675635000696 trimer interface [polypeptide binding]; other site 675635000697 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635000698 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635000699 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 675635000700 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 675635000701 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 675635000702 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635000703 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 675635000704 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635000705 active site 675635000706 catalytic tetrad [active] 675635000707 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 675635000708 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 675635000709 active site 675635000710 dimer interface [polypeptide binding]; other site 675635000711 metal binding site [ion binding]; metal-binding site 675635000712 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 675635000713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635000714 motif II; other site 675635000715 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 675635000716 nucleotide binding site [chemical binding]; other site 675635000717 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635000718 MULE transposase domain; Region: MULE; pfam10551 675635000719 hypothetical protein; Provisional; Region: PRK06541 675635000720 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635000721 inhibitor-cofactor binding pocket; inhibition site 675635000722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635000723 catalytic residue [active] 675635000724 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635000725 homodimer interface [polypeptide binding]; other site 675635000726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635000727 catalytic residue [active] 675635000728 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 675635000729 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635000730 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 675635000731 active site 675635000732 ATP binding site [chemical binding]; other site 675635000733 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 675635000734 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 675635000735 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 675635000736 Walker A/P-loop; other site 675635000737 ATP binding site [chemical binding]; other site 675635000738 Q-loop/lid; other site 675635000739 ABC transporter signature motif; other site 675635000740 Walker B; other site 675635000741 D-loop; other site 675635000742 H-loop/switch region; other site 675635000743 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635000744 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 675635000745 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635000746 Walker A/P-loop; other site 675635000747 ATP binding site [chemical binding]; other site 675635000748 Q-loop/lid; other site 675635000749 ABC transporter signature motif; other site 675635000750 Walker B; other site 675635000751 D-loop; other site 675635000752 H-loop/switch region; other site 675635000753 Helix-turn-helix domains; Region: HTH; cl00088 675635000754 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635000755 anti sigma factor interaction site; other site 675635000756 regulatory phosphorylation site [posttranslational modification]; other site 675635000757 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 675635000758 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635000759 TIGR03086 family protein; Region: TIGR03086 675635000760 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635000761 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635000762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635000763 active site 675635000764 phosphorylation site [posttranslational modification] 675635000765 intermolecular recognition site; other site 675635000766 dimerization interface [polypeptide binding]; other site 675635000767 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635000768 DNA binding residues [nucleotide binding] 675635000769 dimerization interface [polypeptide binding]; other site 675635000770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635000771 Histidine kinase; Region: HisKA_3; pfam07730 675635000772 Helix-turn-helix domains; Region: HTH; cl00088 675635000773 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 675635000774 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635000775 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 675635000776 Walker A/P-loop; other site 675635000777 ATP binding site [chemical binding]; other site 675635000778 Q-loop/lid; other site 675635000779 ABC transporter signature motif; other site 675635000780 Walker B; other site 675635000781 D-loop; other site 675635000782 H-loop/switch region; other site 675635000783 ABC-2 type transporter; Region: ABC2_membrane; cl11417 675635000784 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 675635000785 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635000786 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 675635000787 Zn binding site [ion binding]; other site 675635000788 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 675635000789 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 675635000790 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 675635000791 putative DNA binding site [nucleotide binding]; other site 675635000792 putative homodimer interface [polypeptide binding]; other site 675635000793 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 675635000794 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 675635000795 active site 675635000796 DNA binding site [nucleotide binding] 675635000797 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 675635000798 DNA binding site [nucleotide binding] 675635000799 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 675635000800 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 675635000801 prephenate dehydrogenase; Validated; Region: PRK06545 675635000802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000803 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635000804 Amidase; Region: Amidase; cl11426 675635000805 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 675635000806 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 675635000807 metal binding site [ion binding]; metal-binding site 675635000808 dimer interface [polypeptide binding]; other site 675635000809 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 675635000810 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 675635000811 nucleoside/Zn binding site; other site 675635000812 dimer interface [polypeptide binding]; other site 675635000813 catalytic motif [active] 675635000814 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 675635000815 nudix motif; other site 675635000816 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 675635000817 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635000818 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635000819 active site residue [active] 675635000820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635000821 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 675635000822 putative substrate translocation pore; other site 675635000823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635000824 S-adenosylmethionine binding site [chemical binding]; other site 675635000825 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635000826 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635000827 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 675635000828 active site 675635000829 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635000830 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635000831 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635000832 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635000833 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635000834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635000835 DNA-binding site [nucleotide binding]; DNA binding site 675635000836 FCD domain; Region: FCD; cl11656 675635000837 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 675635000838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635000839 Walker A motif; other site 675635000840 ATP binding site [chemical binding]; other site 675635000841 Walker B motif; other site 675635000842 arginine finger; other site 675635000843 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 675635000844 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 675635000845 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635000846 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635000847 Membrane transport protein; Region: Mem_trans; cl09117 675635000848 Helix-turn-helix domains; Region: HTH; cl00088 675635000849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635000850 dimerization interface [polypeptide binding]; other site 675635000851 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 675635000852 active site 675635000853 metal binding site [ion binding]; metal-binding site 675635000854 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 675635000855 recombination protein RecR; Reviewed; Region: recR; PRK00076 675635000856 RecR protein; Region: RecR; pfam02132 675635000857 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 675635000858 putative active site [active] 675635000859 putative metal-binding site [ion binding]; other site 675635000860 tetramer interface [polypeptide binding]; other site 675635000861 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635000862 Domain of unknown function (DUF397); Region: DUF397; pfam04149 675635000863 2-isopropylmalate synthase; Validated; Region: PRK03739 675635000864 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 675635000865 active site 675635000866 catalytic residues [active] 675635000867 metal binding site [ion binding]; metal-binding site 675635000868 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 675635000869 aspartate kinase; Reviewed; Region: PRK06635 675635000870 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 675635000871 putative nucleotide binding site [chemical binding]; other site 675635000872 putative catalytic residues [active] 675635000873 putative Mg ion binding site [ion binding]; other site 675635000874 putative aspartate binding site [chemical binding]; other site 675635000875 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 675635000876 putative allosteric regulatory site; other site 675635000877 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 675635000878 putative allosteric regulatory residue; other site 675635000879 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 675635000880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000881 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 675635000882 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 675635000883 active site clefts [active] 675635000884 zinc binding site [ion binding]; other site 675635000885 dimer interface [polypeptide binding]; other site 675635000886 Protein of unknown function, DUF393; Region: DUF393; cl01136 675635000887 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 675635000888 ArsC family; Region: ArsC; pfam03960 675635000889 catalytic residues [active] 675635000890 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 675635000891 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 675635000892 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 675635000893 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635000894 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635000895 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 675635000896 Helix-turn-helix domains; Region: HTH; cl00088 675635000897 Cupin domain; Region: Cupin_2; cl09118 675635000898 Helix-turn-helix domains; Region: HTH; cl00088 675635000899 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 675635000900 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635000901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635000902 YCII-related domain; Region: YCII; cl00999 675635000903 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 675635000904 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635000905 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 675635000906 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 675635000907 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 675635000908 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 675635000909 B12 binding site [chemical binding]; other site 675635000910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000911 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 675635000912 conserved cys residue [active] 675635000913 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 675635000914 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 675635000915 conserved cys residue [active] 675635000916 Carboxylesterase family; Region: COesterase; pfam00135 675635000917 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635000918 substrate binding pocket [chemical binding]; other site 675635000919 catalytic triad [active] 675635000920 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 675635000921 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 675635000922 putative active site [active] 675635000923 putative metal binding site [ion binding]; other site 675635000924 GatB domain; Region: GatB_Yqey; cl11497 675635000925 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 675635000926 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 675635000927 active site 675635000928 interdomain interaction site; other site 675635000929 putative metal-binding site [ion binding]; other site 675635000930 nucleotide binding site [chemical binding]; other site 675635000931 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 675635000932 domain I; other site 675635000933 phosphate binding site [ion binding]; other site 675635000934 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 675635000935 domain II; other site 675635000936 domain III; other site 675635000937 nucleotide binding site [chemical binding]; other site 675635000938 DNA binding groove [nucleotide binding] 675635000939 catalytic site [active] 675635000940 domain IV; other site 675635000941 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 675635000942 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 675635000943 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 675635000944 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 675635000945 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 675635000946 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 675635000947 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635000948 ATP binding site [chemical binding]; other site 675635000949 putative Mg++ binding site [ion binding]; other site 675635000950 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 675635000951 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 675635000952 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 675635000953 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 675635000954 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 675635000955 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 675635000956 Walker A motif; other site 675635000957 hexamer interface [polypeptide binding]; other site 675635000958 ATP binding site [chemical binding]; other site 675635000959 Walker B motif; other site 675635000960 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 675635000961 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635000962 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 675635000963 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635000964 acetyl-CoA synthetase; Provisional; Region: PRK00174 675635000965 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 675635000966 AMP-binding enzyme; Region: AMP-binding; cl15778 675635000967 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635000968 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635000969 MoxR-like ATPases [General function prediction only]; Region: COG0714 675635000970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635000971 Walker A motif; other site 675635000972 ATP binding site [chemical binding]; other site 675635000973 Walker B motif; other site 675635000974 arginine finger; other site 675635000975 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 675635000976 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 675635000977 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 675635000978 metal ion-dependent adhesion site (MIDAS); other site 675635000979 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 675635000980 metal ion-dependent adhesion site (MIDAS); other site 675635000981 RF-1 domain; Region: RF-1; cl02875 675635000982 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 675635000983 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 675635000984 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635000985 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635000986 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 675635000987 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 675635000988 active site 675635000989 catalytic site [active] 675635000990 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 675635000991 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 675635000992 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635000993 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 675635000994 Helix-turn-helix domains; Region: HTH; cl00088 675635000995 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 675635000996 dimerization interface [polypeptide binding]; other site 675635000997 substrate binding pocket [chemical binding]; other site 675635000998 aspartate aminotransferase; Provisional; Region: PRK05764 675635000999 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635001000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635001001 homodimer interface [polypeptide binding]; other site 675635001002 catalytic residue [active] 675635001003 Ion channel; Region: Ion_trans_2; cl11596 675635001004 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635001005 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 675635001006 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635001007 catalytic residue [active] 675635001008 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 675635001009 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635001010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635001011 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 675635001012 adenylosuccinate lyase; Region: purB; TIGR00928 675635001013 tetramer interface [polypeptide binding]; other site 675635001014 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 675635001015 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 675635001016 ATP binding site [chemical binding]; other site 675635001017 active site 675635001018 substrate binding site [chemical binding]; other site 675635001019 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 675635001020 putative active site [active] 675635001021 putative Zn binding site [ion binding]; other site 675635001022 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635001023 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 675635001024 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 675635001025 conserved cys residue [active] 675635001026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635001027 active site 675635001028 phosphorylation site [posttranslational modification] 675635001029 intermolecular recognition site; other site 675635001030 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 675635001031 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 675635001032 CHASE3 domain; Region: CHASE3; cl05000 675635001033 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 675635001034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635001035 dimer interface [polypeptide binding]; other site 675635001036 phosphorylation site [posttranslational modification] 675635001037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635001038 ATP binding site [chemical binding]; other site 675635001039 Mg2+ binding site [ion binding]; other site 675635001040 G-X-G motif; other site 675635001041 Response regulator receiver domain; Region: Response_reg; pfam00072 675635001042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635001043 active site 675635001044 phosphorylation site [posttranslational modification] 675635001045 intermolecular recognition site; other site 675635001046 dimerization interface [polypeptide binding]; other site 675635001047 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 675635001048 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 675635001049 dimerization interface [polypeptide binding]; other site 675635001050 ATP binding site [chemical binding]; other site 675635001051 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 675635001052 dimerization interface [polypeptide binding]; other site 675635001053 ATP binding site [chemical binding]; other site 675635001054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635001055 PAS domain; Region: PAS_9; pfam13426 675635001056 putative active site [active] 675635001057 heme pocket [chemical binding]; other site 675635001058 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635001059 metal binding site [ion binding]; metal-binding site 675635001060 active site 675635001061 I-site; other site 675635001062 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 675635001063 amidophosphoribosyltransferase; Provisional; Region: PRK07847 675635001064 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 675635001065 active site 675635001066 tetramer interface [polypeptide binding]; other site 675635001067 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635001068 active site 675635001069 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 675635001070 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 675635001071 dimerization interface [polypeptide binding]; other site 675635001072 putative ATP binding site [chemical binding]; other site 675635001073 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635001074 nudix motif; other site 675635001075 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635001076 Predicted transcriptional regulators [Transcription]; Region: COG1725 675635001077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635001078 DNA-binding site [nucleotide binding]; DNA binding site 675635001079 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 675635001080 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 675635001081 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 675635001082 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 675635001083 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 675635001084 metal binding site 2 [ion binding]; metal-binding site 675635001085 putative DNA binding helix; other site 675635001086 metal binding site 1 [ion binding]; metal-binding site 675635001087 dimer interface [polypeptide binding]; other site 675635001088 structural Zn2+ binding site [ion binding]; other site 675635001089 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 675635001090 heme-binding site [chemical binding]; other site 675635001091 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 675635001092 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 675635001093 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 675635001094 active site residue [active] 675635001095 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 675635001096 active site residue [active] 675635001097 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 675635001098 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 675635001099 catalytic residues [active] 675635001100 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 675635001101 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635001102 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635001103 DNA binding site [nucleotide binding] 675635001104 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 675635001105 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635001106 Coenzyme A binding pocket [chemical binding]; other site 675635001107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635001108 Coenzyme A binding pocket [chemical binding]; other site 675635001109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635001110 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 675635001111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635001112 dimer interface [polypeptide binding]; other site 675635001113 conserved gate region; other site 675635001114 putative PBP binding loops; other site 675635001115 ABC-ATPase subunit interface; other site 675635001116 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 675635001117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635001118 dimer interface [polypeptide binding]; other site 675635001119 conserved gate region; other site 675635001120 putative PBP binding loops; other site 675635001121 ABC-ATPase subunit interface; other site 675635001122 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 675635001123 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 675635001124 Walker A/P-loop; other site 675635001125 ATP binding site [chemical binding]; other site 675635001126 Q-loop/lid; other site 675635001127 ABC transporter signature motif; other site 675635001128 Walker B; other site 675635001129 D-loop; other site 675635001130 H-loop/switch region; other site 675635001131 PhoU domain; Region: PhoU; pfam01895 675635001132 PhoU domain; Region: PhoU; pfam01895 675635001133 Dodecin; Region: Dodecin; cl01328 675635001134 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 675635001135 PhoU domain; Region: PhoU; pfam01895 675635001136 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 675635001137 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 675635001138 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635001139 metal binding site [ion binding]; metal-binding site 675635001140 active site 675635001141 I-site; other site 675635001142 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 675635001143 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 675635001144 FMN binding site [chemical binding]; other site 675635001145 active site 675635001146 catalytic residues [active] 675635001147 substrate binding site [chemical binding]; other site 675635001148 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 675635001149 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08332 675635001150 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 675635001151 homotrimer interaction site [polypeptide binding]; other site 675635001152 putative active site [active] 675635001153 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 675635001154 homotrimer interaction site [polypeptide binding]; other site 675635001155 putative active site [active] 675635001156 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 675635001157 homotrimer interaction site [polypeptide binding]; other site 675635001158 putative active site [active] 675635001159 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 675635001160 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 675635001161 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635001162 DNA-binding site [nucleotide binding]; DNA binding site 675635001163 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635001164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635001165 homodimer interface [polypeptide binding]; other site 675635001166 catalytic residue [active] 675635001167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001169 NADH(P)-binding; Region: NAD_binding_10; pfam13460 675635001170 NAD(P) binding site [chemical binding]; other site 675635001171 active site 675635001172 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635001173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001174 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 675635001175 active site 675635001176 replication factor C large subunit; Provisional; Region: PRK04195 675635001177 CAAX protease self-immunity; Region: Abi; cl00558 675635001178 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635001179 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635001180 metal binding site [ion binding]; metal-binding site 675635001181 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635001182 active site 675635001183 metal binding site [ion binding]; metal-binding site 675635001184 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635001185 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635001186 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635001187 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635001188 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635001189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001190 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635001191 NAD(P) binding site [chemical binding]; other site 675635001192 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635001193 Helix-turn-helix domains; Region: HTH; cl00088 675635001194 Helix-turn-helix domains; Region: HTH; cl00088 675635001195 Helix-turn-helix domains; Region: HTH; cl00088 675635001196 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635001197 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635001198 AMP-binding domain protein; Validated; Region: PRK08315 675635001199 AMP-binding enzyme; Region: AMP-binding; cl15778 675635001200 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635001201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001202 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 675635001203 NAD(P) binding site [chemical binding]; other site 675635001204 active site 675635001205 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 675635001206 enoyl-CoA hydratase; Provisional; Region: PRK06688 675635001207 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635001208 substrate binding site [chemical binding]; other site 675635001209 oxyanion hole (OAH) forming residues; other site 675635001210 trimer interface [polypeptide binding]; other site 675635001211 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635001212 active site 2 [active] 675635001213 active site 1 [active] 675635001214 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 675635001215 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 675635001216 putative active site [active] 675635001217 putative substrate binding site [chemical binding]; other site 675635001218 ATP binding site [chemical binding]; other site 675635001219 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635001220 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635001221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635001222 Helix-turn-helix domains; Region: HTH; cl00088 675635001223 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 675635001224 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 675635001225 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 675635001226 dimer interface [polypeptide binding]; other site 675635001227 active site 675635001228 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635001229 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635001230 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635001231 AMP-binding enzyme; Region: AMP-binding; cl15778 675635001232 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635001233 TM-ABC transporter signature motif; other site 675635001234 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635001235 TM-ABC transporter signature motif; other site 675635001236 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635001237 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 675635001238 Walker A/P-loop; other site 675635001239 ATP binding site [chemical binding]; other site 675635001240 Q-loop/lid; other site 675635001241 ABC transporter signature motif; other site 675635001242 Walker B; other site 675635001243 D-loop; other site 675635001244 H-loop/switch region; other site 675635001245 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 675635001246 Walker A/P-loop; other site 675635001247 ATP binding site [chemical binding]; other site 675635001248 ABC transporter; Region: ABC_tran; pfam00005 675635001249 Q-loop/lid; other site 675635001250 ABC transporter signature motif; other site 675635001251 Walker B; other site 675635001252 D-loop; other site 675635001253 H-loop/switch region; other site 675635001254 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635001255 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635001256 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635001257 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635001258 substrate binding site [chemical binding]; other site 675635001259 oxyanion hole (OAH) forming residues; other site 675635001260 trimer interface [polypeptide binding]; other site 675635001261 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 675635001262 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 675635001263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635001264 Helix-turn-helix domains; Region: HTH; cl00088 675635001265 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635001266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635001267 active site 675635001268 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635001269 classical (c) SDRs; Region: SDR_c; cd05233 675635001270 NAD(P) binding site [chemical binding]; other site 675635001271 active site 675635001272 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635001273 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635001274 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 675635001275 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635001276 active site 675635001277 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635001278 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635001279 active site 675635001280 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635001281 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 675635001282 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635001283 active site 675635001284 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 675635001285 Protein export membrane protein; Region: SecD_SecF; cl14618 675635001286 Protein export membrane protein; Region: SecD_SecF; cl14618 675635001287 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 675635001288 NADP+ binding site [chemical binding]; other site 675635001289 folate binding site [chemical binding]; other site 675635001290 Cation efflux family; Region: Cation_efflux; cl00316 675635001291 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635001292 dimerization interface [polypeptide binding]; other site 675635001293 putative DNA binding site [nucleotide binding]; other site 675635001294 putative Zn2+ binding site [ion binding]; other site 675635001295 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 675635001296 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 675635001297 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 675635001298 catalytic residue [active] 675635001299 Protein of unknown function DUF111; Region: DUF111; cl03398 675635001300 Tic20-like protein; Region: Tic20; pfam09685 675635001301 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 675635001302 classical (c) SDRs; Region: SDR_c; cd05233 675635001303 NAD(P) binding site [chemical binding]; other site 675635001304 active site 675635001305 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 675635001306 quinone interaction residues [chemical binding]; other site 675635001307 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 675635001308 active site 675635001309 catalytic residues [active] 675635001310 FMN binding site [chemical binding]; other site 675635001311 substrate binding site [chemical binding]; other site 675635001312 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 675635001313 RNA binding surface [nucleotide binding]; other site 675635001314 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635001315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001316 NAD(P) binding site [chemical binding]; other site 675635001317 active site 675635001318 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 675635001319 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 675635001320 AMP-binding enzyme; Region: AMP-binding; cl15778 675635001321 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 675635001322 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 675635001323 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635001324 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635001325 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 675635001326 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635001327 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 675635001328 Response regulator receiver domain; Region: Response_reg; pfam00072 675635001329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635001330 active site 675635001331 phosphorylation site [posttranslational modification] 675635001332 intermolecular recognition site; other site 675635001333 dimerization interface [polypeptide binding]; other site 675635001334 PAS domain S-box; Region: sensory_box; TIGR00229 675635001335 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 675635001336 GAF domain; Region: GAF; cl15785 675635001337 GAF domain; Region: GAF; cl15785 675635001338 GAF domain; Region: GAF_2; pfam13185 675635001339 GAF domain; Region: GAF; cl15785 675635001340 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 675635001341 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 675635001342 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635001343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635001344 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635001345 anti sigma factor interaction site; other site 675635001346 regulatory phosphorylation site [posttranslational modification]; other site 675635001347 Cysteine dioxygenase type I; Region: CDO_I; cl15835 675635001348 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635001349 active site residue [active] 675635001350 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635001351 acyl-coenzyme A oxidase; Region: PLN02526 675635001352 active site 675635001353 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 675635001354 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 675635001355 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635001356 ATP binding site [chemical binding]; other site 675635001357 putative Mg++ binding site [ion binding]; other site 675635001358 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635001359 nucleotide binding region [chemical binding]; other site 675635001360 ATP-binding site [chemical binding]; other site 675635001361 Helicase associated domain (HA2); Region: HA2; cl04503 675635001362 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 675635001363 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 675635001364 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635001365 Protein of unknown function DUF72; Region: DUF72; cl00777 675635001366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001367 acyl-CoA synthetase; Validated; Region: PRK08162 675635001368 AMP-binding enzyme; Region: AMP-binding; cl15778 675635001369 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635001370 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 675635001371 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 675635001372 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 675635001373 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 675635001374 AMP-binding enzyme; Region: AMP-binding; cl15778 675635001375 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635001376 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635001377 active site 675635001378 catalytic triad [active] 675635001379 oxyanion hole [active] 675635001380 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635001381 metal-binding site [ion binding] 675635001382 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 675635001383 putative homotetramer interface [polypeptide binding]; other site 675635001384 putative homodimer interface [polypeptide binding]; other site 675635001385 putative allosteric switch controlling residues; other site 675635001386 putative metal binding site [ion binding]; other site 675635001387 putative homodimer-homodimer interface [polypeptide binding]; other site 675635001388 FAD binding domain; Region: FAD_binding_3; pfam01494 675635001389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001390 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635001391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001392 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635001393 Helix-turn-helix domains; Region: HTH; cl00088 675635001394 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 675635001395 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 675635001396 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 675635001397 DXD motif; other site 675635001398 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 675635001399 active site 675635001400 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 675635001401 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 675635001402 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 675635001403 DXD motif; other site 675635001404 Helix-turn-helix domains; Region: HTH; cl00088 675635001405 Cupin domain; Region: Cupin_2; cl09118 675635001406 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635001407 Helix-turn-helix domains; Region: HTH; cl00088 675635001408 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 675635001409 DNA-binding site [nucleotide binding]; DNA binding site 675635001410 RNA-binding motif; other site 675635001411 Protein of unknown function (DUF445); Region: DUF445; pfam04286 675635001412 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 675635001413 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635001414 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 675635001415 Walker A/P-loop; other site 675635001416 ATP binding site [chemical binding]; other site 675635001417 Q-loop/lid; other site 675635001418 ABC transporter signature motif; other site 675635001419 Walker B; other site 675635001420 D-loop; other site 675635001421 H-loop/switch region; other site 675635001422 ABC-2 type transporter; Region: ABC2_membrane; cl11417 675635001423 CrcB-like protein; Region: CRCB; cl09114 675635001424 CrcB-like protein; Region: CRCB; cl09114 675635001425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635001426 non-specific DNA binding site [nucleotide binding]; other site 675635001427 salt bridge; other site 675635001428 sequence-specific DNA binding site [nucleotide binding]; other site 675635001429 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 675635001430 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 675635001431 putative deacylase active site [active] 675635001432 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 675635001433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635001434 Walker A motif; other site 675635001435 ATP binding site [chemical binding]; other site 675635001436 Walker B motif; other site 675635001437 arginine finger; other site 675635001438 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 675635001439 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 675635001440 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 675635001441 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 675635001442 putative active site [active] 675635001443 putative substrate binding site [chemical binding]; other site 675635001444 putative cosubstrate binding site; other site 675635001445 catalytic site [active] 675635001446 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 675635001447 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 675635001448 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 675635001449 FAD binding domain; Region: FAD_binding_4; pfam01565 675635001450 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 675635001451 Bacterial Ig-like domain; Region: Big_5; cl01012 675635001452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 675635001453 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 675635001454 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 675635001455 NAD(P) binding site [chemical binding]; other site 675635001456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001457 NAD(P) binding site [chemical binding]; other site 675635001458 active site 675635001459 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 675635001460 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 675635001461 H+ Antiporter protein; Region: 2A0121; TIGR00900 675635001462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001463 putative substrate translocation pore; other site 675635001464 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 675635001465 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 675635001466 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 675635001467 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635001468 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 675635001469 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635001470 catalytic residue [active] 675635001471 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 675635001472 Citrate synthase; Region: Citrate_synt; pfam00285 675635001473 oxalacetate binding site [chemical binding]; other site 675635001474 citrylCoA binding site [chemical binding]; other site 675635001475 coenzyme A binding site [chemical binding]; other site 675635001476 catalytic triad [active] 675635001477 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 675635001478 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635001479 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 675635001480 H+ Antiporter protein; Region: 2A0121; TIGR00900 675635001481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001482 putative substrate translocation pore; other site 675635001483 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 675635001484 dimer interface [polypeptide binding]; other site 675635001485 Citrate synthase; Region: Citrate_synt; pfam00285 675635001486 active site 675635001487 citrylCoA binding site [chemical binding]; other site 675635001488 NADH binding [chemical binding]; other site 675635001489 cationic pore residues; other site 675635001490 oxalacetate/citrate binding site [chemical binding]; other site 675635001491 coenzyme A binding site [chemical binding]; other site 675635001492 catalytic triad [active] 675635001493 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 675635001494 DNA photolyase; Region: DNA_photolyase; pfam00875 675635001495 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 675635001496 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 675635001497 Helix-turn-helix domains; Region: HTH; cl00088 675635001498 hypothetical protein; Provisional; Region: PRK06834 675635001499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001500 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 675635001501 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 675635001502 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 675635001503 Walker A/P-loop; other site 675635001504 ATP binding site [chemical binding]; other site 675635001505 Q-loop/lid; other site 675635001506 ABC transporter signature motif; other site 675635001507 Walker B; other site 675635001508 D-loop; other site 675635001509 H-loop/switch region; other site 675635001510 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635001511 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635001512 DNA-binding site [nucleotide binding]; DNA binding site 675635001513 FCD domain; Region: FCD; cl11656 675635001514 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 675635001515 DctM-like transporters; Region: DctM; pfam06808 675635001516 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635001517 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635001518 AMP-binding enzyme; Region: AMP-binding; cl15778 675635001519 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635001520 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635001521 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635001522 NMT1-like family; Region: NMT1_2; cl15260 675635001523 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 675635001524 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635001525 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635001526 thiolase; Provisional; Region: PRK06158 675635001527 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635001528 active site 675635001529 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635001530 GAF domain; Region: GAF; cl15785 675635001531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635001532 Walker A motif; other site 675635001533 ATP binding site [chemical binding]; other site 675635001534 Walker B motif; other site 675635001535 arginine finger; other site 675635001536 Helix-turn-helix domains; Region: HTH; cl00088 675635001537 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635001538 dinuclear metal binding motif [ion binding]; other site 675635001539 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 675635001540 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635001541 catalytic loop [active] 675635001542 iron binding site [ion binding]; other site 675635001543 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 675635001544 FAD binding pocket [chemical binding]; other site 675635001545 conserved FAD binding motif [chemical binding]; other site 675635001546 phosphate binding motif [ion binding]; other site 675635001547 beta-alpha-beta structure motif; other site 675635001548 NAD binding pocket [chemical binding]; other site 675635001549 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 675635001550 dimerization interface [polypeptide binding]; other site 675635001551 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635001552 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 675635001553 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 675635001554 ring oligomerisation interface [polypeptide binding]; other site 675635001555 ATP/Mg binding site [chemical binding]; other site 675635001556 stacking interactions; other site 675635001557 hinge regions; other site 675635001558 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635001559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001560 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635001561 putative substrate translocation pore; other site 675635001562 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 675635001563 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 675635001564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001565 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635001566 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 675635001567 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 675635001568 NAD binding site [chemical binding]; other site 675635001569 catalytic Zn binding site [ion binding]; other site 675635001570 substrate binding site [chemical binding]; other site 675635001571 structural Zn binding site [ion binding]; other site 675635001572 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635001573 substrate binding site [chemical binding]; other site 675635001574 oxyanion hole (OAH) forming residues; other site 675635001575 trimer interface [polypeptide binding]; other site 675635001576 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635001577 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 675635001578 active site 675635001579 Cupin domain; Region: Cupin_2; cl09118 675635001580 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635001581 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635001582 DNA binding residues [nucleotide binding] 675635001583 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 675635001584 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635001585 dimer interface [polypeptide binding]; other site 675635001586 active site 675635001587 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635001588 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 675635001589 substrate binding site [chemical binding]; other site 675635001590 oxyanion hole (OAH) forming residues; other site 675635001591 trimer interface [polypeptide binding]; other site 675635001592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001593 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 675635001594 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 675635001595 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 675635001596 GAF domain; Region: GAF_2; pfam13185 675635001597 ANTAR domain; Region: ANTAR; cl04297 675635001598 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 675635001599 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635001600 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 675635001601 Walker A/P-loop; other site 675635001602 ATP binding site [chemical binding]; other site 675635001603 Q-loop/lid; other site 675635001604 ABC transporter signature motif; other site 675635001605 Walker B; other site 675635001606 D-loop; other site 675635001607 H-loop/switch region; other site 675635001608 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 675635001609 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 675635001610 Predicted permease; Region: DUF318; pfam03773 675635001611 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635001612 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635001613 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635001614 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635001615 DNA binding residues [nucleotide binding] 675635001616 Putative zinc-finger; Region: zf-HC2; cl15806 675635001617 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 675635001618 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 675635001619 NAD binding site [chemical binding]; other site 675635001620 catalytic Zn binding site [ion binding]; other site 675635001621 substrate binding site [chemical binding]; other site 675635001622 structural Zn binding site [ion binding]; other site 675635001623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001624 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635001625 putative substrate translocation pore; other site 675635001626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001627 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 675635001628 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 675635001629 active site 675635001630 NAD binding site [chemical binding]; other site 675635001631 metal binding site [ion binding]; metal-binding site 675635001632 galactonate dehydratase; Provisional; Region: PRK14017 675635001633 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635001634 metal binding site [ion binding]; metal-binding site 675635001635 substrate binding pocket [chemical binding]; other site 675635001636 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 675635001637 Helix-turn-helix domains; Region: HTH; cl00088 675635001638 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 675635001639 dimerization interface [polypeptide binding]; other site 675635001640 substrate binding pocket [chemical binding]; other site 675635001641 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 675635001642 EamA-like transporter family; Region: EamA; cl01037 675635001643 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 675635001644 homodimer interaction site [polypeptide binding]; other site 675635001645 cofactor binding site; other site 675635001646 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635001647 active site 675635001648 metal binding site [ion binding]; metal-binding site 675635001649 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635001650 GAF domain; Region: GAF; cl15785 675635001651 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635001652 metal binding site [ion binding]; metal-binding site 675635001653 active site 675635001654 I-site; other site 675635001655 Helix-turn-helix domains; Region: HTH; cl00088 675635001656 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635001657 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635001658 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635001659 Protease prsW family; Region: PrsW-protease; cl15823 675635001660 Helix-turn-helix domains; Region: HTH; cl00088 675635001661 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 675635001662 active site clefts [active] 675635001663 zinc binding site [ion binding]; other site 675635001664 dimer interface [polypeptide binding]; other site 675635001665 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635001666 TM-ABC transporter signature motif; other site 675635001667 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635001668 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635001669 ligand binding site [chemical binding]; other site 675635001670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635001671 DNA-binding site [nucleotide binding]; DNA binding site 675635001672 FCD domain; Region: FCD; cl11656 675635001673 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635001674 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635001675 Walker A/P-loop; other site 675635001676 ATP binding site [chemical binding]; other site 675635001677 Q-loop/lid; other site 675635001678 ABC transporter signature motif; other site 675635001679 Walker B; other site 675635001680 D-loop; other site 675635001681 H-loop/switch region; other site 675635001682 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 675635001683 phenylhydantoinase; Validated; Region: PRK08323 675635001684 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635001685 active site 675635001686 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 675635001687 active site 675635001688 homodimer interface [polypeptide binding]; other site 675635001689 homotetramer interface [polypeptide binding]; other site 675635001690 tartrate dehydrogenase; Provisional; Region: PRK08194 675635001691 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 675635001692 Peptidase family M23; Region: Peptidase_M23; pfam01551 675635001693 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635001694 Helix-turn-helix domains; Region: HTH; cl00088 675635001695 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635001696 dimerization interface [polypeptide binding]; other site 675635001697 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 675635001698 tartrate dehydrogenase; Provisional; Region: PRK08194 675635001699 Flavin Reductases; Region: FlaRed; cl00801 675635001700 YCII-related domain; Region: YCII; cl00999 675635001701 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 675635001702 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635001703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635001704 Predicted ATPase [General function prediction only]; Region: COG3903 675635001705 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635001706 DNA binding residues [nucleotide binding] 675635001707 dimerization interface [polypeptide binding]; other site 675635001708 FAD binding domain; Region: FAD_binding_3; pfam01494 675635001709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001710 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 675635001711 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 675635001712 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 675635001713 active site 675635001714 purine riboside binding site [chemical binding]; other site 675635001715 Transport protein; Region: actII; TIGR00833 675635001716 Transport protein; Region: actII; TIGR00833 675635001717 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 675635001718 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 675635001719 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635001720 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635001721 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635001722 Ligand Binding Site [chemical binding]; other site 675635001723 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 675635001724 hypothetical protein; Provisional; Region: PRK07877 675635001725 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 675635001726 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 675635001727 hypothetical protein; Provisional; Region: PRK07877 675635001728 FMN binding site [chemical binding]; other site 675635001729 dimer interface [polypeptide binding]; other site 675635001730 GAF domain; Region: GAF; cl15785 675635001731 Histidine kinase; Region: HisKA_3; pfam07730 675635001732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635001733 ATP binding site [chemical binding]; other site 675635001734 G-X-G motif; other site 675635001735 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635001736 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635001737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635001738 active site 675635001739 phosphorylation site [posttranslational modification] 675635001740 intermolecular recognition site; other site 675635001741 dimerization interface [polypeptide binding]; other site 675635001742 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635001743 DNA binding residues [nucleotide binding] 675635001744 dimerization interface [polypeptide binding]; other site 675635001745 Helix-turn-helix domains; Region: HTH; cl00088 675635001746 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635001747 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 675635001748 active site 675635001749 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635001750 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 675635001751 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 675635001752 Sulfatase; Region: Sulfatase; cl10460 675635001753 Sulfatase; Region: Sulfatase; cl10460 675635001754 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 675635001755 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635001756 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635001757 active site 675635001758 Helix-turn-helix domains; Region: HTH; cl00088 675635001759 Rrf2 family protein; Region: rrf2_super; TIGR00738 675635001760 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635001761 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635001762 active site 675635001763 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635001764 LytTr DNA-binding domain; Region: LytTR; cl04498 675635001765 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 675635001766 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 675635001767 heme binding site [chemical binding]; other site 675635001768 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 675635001769 heme binding site [chemical binding]; other site 675635001770 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 675635001771 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 675635001772 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 675635001773 dimer interface [polypeptide binding]; other site 675635001774 Trp docking motif [polypeptide binding]; other site 675635001775 active site 675635001776 PqqA family; Region: PqqA; cl15372 675635001777 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635001778 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 675635001779 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 675635001780 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 675635001781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635001782 FeS/SAM binding site; other site 675635001783 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 675635001784 Predicted membrane protein [Function unknown]; Region: COG1971 675635001785 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 675635001786 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 675635001787 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 675635001788 SLBB domain; Region: SLBB; pfam10531 675635001789 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 675635001790 ApbE family; Region: ApbE; cl00643 675635001791 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 675635001792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635001793 active site 675635001794 phosphorylation site [posttranslational modification] 675635001795 intermolecular recognition site; other site 675635001796 dimerization interface [polypeptide binding]; other site 675635001797 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635001798 DNA binding site [nucleotide binding] 675635001799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635001800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635001801 ATP binding site [chemical binding]; other site 675635001802 Mg2+ binding site [ion binding]; other site 675635001803 G-X-G motif; other site 675635001804 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635001805 dimerization interface [polypeptide binding]; other site 675635001806 putative DNA binding site [nucleotide binding]; other site 675635001807 putative Zn2+ binding site [ion binding]; other site 675635001808 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 675635001809 hydrogenase 4 subunit B; Validated; Region: PRK06521 675635001810 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 675635001811 hydrogenase 4 subunit B; Validated; Region: PRK06521 675635001812 NADH dehydrogenase; Region: NADHdh; cl00469 675635001813 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 675635001814 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 675635001815 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 675635001816 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 675635001817 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 675635001818 Muconolactone delta-isomerase; Region: MIase; cl01992 675635001819 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 675635001820 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635001821 active site 675635001822 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 675635001823 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 675635001824 active site 675635001825 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 675635001826 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635001827 catalytic loop [active] 675635001828 iron binding site [ion binding]; other site 675635001829 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 675635001830 FAD binding pocket [chemical binding]; other site 675635001831 FAD binding motif [chemical binding]; other site 675635001832 phosphate binding motif [ion binding]; other site 675635001833 beta-alpha-beta structure motif; other site 675635001834 NAD binding pocket [chemical binding]; other site 675635001835 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 675635001836 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635001837 dinuclear metal binding motif [ion binding]; other site 675635001838 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635001839 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635001840 dinuclear metal binding motif [ion binding]; other site 675635001841 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 675635001842 Helix-turn-helix domains; Region: HTH; cl00088 675635001843 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 675635001844 dimerization interface [polypeptide binding]; other site 675635001845 substrate binding pocket [chemical binding]; other site 675635001846 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635001847 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 675635001848 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635001849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635001850 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635001851 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 675635001852 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 675635001853 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635001854 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 675635001855 dimer interface [polypeptide binding]; other site 675635001856 active site 675635001857 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 675635001858 Helix-turn-helix domains; Region: HTH; cl00088 675635001859 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 675635001860 dimerization interface [polypeptide binding]; other site 675635001861 substrate binding pocket [chemical binding]; other site 675635001862 Methyltransferase domain; Region: Methyltransf_31; pfam13847 675635001863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635001864 S-adenosylmethionine binding site [chemical binding]; other site 675635001865 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 675635001866 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 675635001867 putative active site [active] 675635001868 putative metal binding site [ion binding]; other site 675635001869 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 675635001870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001871 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635001872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635001873 active site 675635001874 phosphorylation site [posttranslational modification] 675635001875 intermolecular recognition site; other site 675635001876 dimerization interface [polypeptide binding]; other site 675635001877 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635001878 DNA binding site [nucleotide binding] 675635001879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 675635001880 dimerization interface [polypeptide binding]; other site 675635001881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635001882 dimer interface [polypeptide binding]; other site 675635001883 phosphorylation site [posttranslational modification] 675635001884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635001885 ATP binding site [chemical binding]; other site 675635001886 Mg2+ binding site [ion binding]; other site 675635001887 G-X-G motif; other site 675635001888 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635001889 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 675635001890 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 675635001891 MPT binding site; other site 675635001892 trimer interface [polypeptide binding]; other site 675635001893 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635001894 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635001895 putative NAD(P) binding site [chemical binding]; other site 675635001896 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 675635001897 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635001898 Helix-turn-helix domains; Region: HTH; cl00088 675635001899 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635001900 dimerization interface [polypeptide binding]; other site 675635001901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001902 NAD(P) binding site [chemical binding]; other site 675635001903 active site 675635001904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001905 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 675635001906 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 675635001907 SAF domain; Region: SAF; cl00555 675635001908 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 675635001909 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 675635001910 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 675635001911 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635001912 active site 675635001913 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 675635001914 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 675635001915 dimer interface [polypeptide binding]; other site 675635001916 putative functional site; other site 675635001917 putative MPT binding site; other site 675635001918 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 675635001919 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635001920 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 675635001921 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 675635001922 catalytic residues [active] 675635001923 catalytic nucleophile [active] 675635001924 Presynaptic Site I dimer interface [polypeptide binding]; other site 675635001925 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 675635001926 Synaptic Flat tetramer interface [polypeptide binding]; other site 675635001927 Synaptic Site I dimer interface [polypeptide binding]; other site 675635001928 DNA binding site [nucleotide binding] 675635001929 Recombinase; Region: Recombinase; pfam07508 675635001930 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 675635001931 Replication-relaxation; Region: Replic_Relax; pfam13814 675635001932 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635001933 E3 interaction surface; other site 675635001934 lipoyl attachment site [posttranslational modification]; other site 675635001935 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 675635001936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635001937 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635001938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635001939 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 675635001940 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cl00327 675635001941 Domain of unknown function DUF59; Region: DUF59; cl00941 675635001942 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 675635001943 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635001944 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 675635001945 [2Fe-2S] cluster binding site [ion binding]; other site 675635001946 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635001947 dinuclear metal binding motif [ion binding]; other site 675635001948 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635001949 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 675635001950 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635001951 dinuclear metal binding motif [ion binding]; other site 675635001952 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635001953 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635001954 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 675635001955 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 675635001956 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 675635001957 potential catalytic triad [active] 675635001958 conserved cys residue [active] 675635001959 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 675635001960 potential catalytic triad [active] 675635001961 conserved cys residue [active] 675635001962 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 675635001963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635001964 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635001965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635001966 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 675635001967 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 675635001968 octamer interface [polypeptide binding]; other site 675635001969 active site 675635001970 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635001971 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635001972 Helix-turn-helix domains; Region: HTH; cl00088 675635001973 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635001974 Helix-turn-helix domains; Region: HTH; cl00088 675635001975 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 675635001976 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 675635001977 Predicted methyltransferases [General function prediction only]; Region: COG0313 675635001978 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 675635001979 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 675635001980 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 675635001981 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 675635001982 Chorismate mutase type II; Region: CM_2; cl00693 675635001983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 675635001984 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635001985 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 675635001986 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 675635001987 active site 675635001988 HIGH motif; other site 675635001989 KMSKS motif; other site 675635001990 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 675635001991 tRNA binding surface [nucleotide binding]; other site 675635001992 anticodon binding site; other site 675635001993 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 675635001994 active site 675635001995 Domain of unknown function (DUF348); Region: DUF348; pfam03990 675635001996 Domain of unknown function (DUF348); Region: DUF348; pfam03990 675635001997 G5 domain; Region: G5; pfam07501 675635001998 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 675635001999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002000 Helix-turn-helix domains; Region: HTH; cl00088 675635002001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635002002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635002003 putative substrate translocation pore; other site 675635002004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635002005 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 675635002006 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 675635002007 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 675635002008 ABC transporter; Region: ABC_tran_2; pfam12848 675635002009 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 675635002010 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635002011 Helix-turn-helix domains; Region: HTH; cl00088 675635002012 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002013 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 675635002014 Walker A/P-loop; other site 675635002015 ATP binding site [chemical binding]; other site 675635002016 Q-loop/lid; other site 675635002017 ABC transporter signature motif; other site 675635002018 Walker B; other site 675635002019 D-loop; other site 675635002020 H-loop/switch region; other site 675635002021 ABC-2 type transporter; Region: ABC2_membrane; cl11417 675635002022 Helix-turn-helix domains; Region: HTH; cl00088 675635002023 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 675635002024 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002025 Predicted ATPase [General function prediction only]; Region: COG3903 675635002026 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 675635002027 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 675635002028 active site 675635002029 metal binding site [ion binding]; metal-binding site 675635002030 dimer interface [polypeptide binding]; other site 675635002031 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 675635002032 AMP-binding enzyme; Region: AMP-binding; cl15778 675635002033 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 675635002034 putative active site [active] 675635002035 catalytic residue [active] 675635002036 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 675635002037 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 675635002038 5S rRNA interface [nucleotide binding]; other site 675635002039 CTC domain interface [polypeptide binding]; other site 675635002040 L16 interface [polypeptide binding]; other site 675635002041 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002042 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 675635002043 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635002044 MULE transposase domain; Region: MULE; pfam10551 675635002045 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 675635002046 Integrase core domain; Region: rve; cl01316 675635002047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635002048 Walker A motif; other site 675635002049 ATP binding site [chemical binding]; other site 675635002050 Walker B motif; other site 675635002051 arginine finger; other site 675635002052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635002053 Integrase core domain; Region: rve; cl01316 675635002054 AAA domain; Region: AAA_25; pfam13481 675635002055 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635002056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635002057 non-specific DNA binding site [nucleotide binding]; other site 675635002058 salt bridge; other site 675635002059 sequence-specific DNA binding site [nucleotide binding]; other site 675635002060 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 675635002061 Int/Topo IB signature motif; other site 675635002062 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 675635002063 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 675635002064 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635002065 active site 675635002066 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 675635002067 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 675635002068 Substrate binding site; other site 675635002069 Mg++ binding site; other site 675635002070 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 675635002071 active site 675635002072 substrate binding site [chemical binding]; other site 675635002073 CoA binding site [chemical binding]; other site 675635002074 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 675635002075 OsmC-like protein; Region: OsmC; cl00767 675635002076 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 675635002077 Di-iron ligands [ion binding]; other site 675635002078 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635002079 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 675635002080 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 675635002081 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 675635002082 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 675635002083 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 675635002084 protein binding site [polypeptide binding]; other site 675635002085 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 675635002086 Domain interface; other site 675635002087 Peptide binding site; other site 675635002088 Active site tetrad [active] 675635002089 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 675635002090 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 675635002091 Walker A/P-loop; other site 675635002092 ATP binding site [chemical binding]; other site 675635002093 Q-loop/lid; other site 675635002094 ABC transporter signature motif; other site 675635002095 Walker B; other site 675635002096 D-loop; other site 675635002097 H-loop/switch region; other site 675635002098 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 675635002099 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 675635002100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635002101 ATP binding site [chemical binding]; other site 675635002102 putative Mg++ binding site [ion binding]; other site 675635002103 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635002104 nucleotide binding region [chemical binding]; other site 675635002105 ATP-binding site [chemical binding]; other site 675635002106 TRCF domain; Region: TRCF; cl04088 675635002107 SurA N-terminal domain; Region: SurA_N_3; cl07813 675635002108 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 675635002109 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 675635002110 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635002111 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 675635002112 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 675635002113 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 675635002114 Imelysin; Region: Peptidase_M75; cl09159 675635002115 Iron permease FTR1 family; Region: FTR1; cl00475 675635002116 Iron permease FTR1 family; Region: FTR1; cl00475 675635002117 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 675635002118 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 675635002119 Imelysin; Region: Peptidase_M75; cl09159 675635002120 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 675635002121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 675635002122 binding surface 675635002123 TPR motif; other site 675635002124 TPR repeat; Region: TPR_11; pfam13414 675635002125 enolase; Provisional; Region: eno; PRK00077 675635002126 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 675635002127 dimer interface [polypeptide binding]; other site 675635002128 metal binding site [ion binding]; metal-binding site 675635002129 substrate binding pocket [chemical binding]; other site 675635002130 Protein of unknown function (DUF501); Region: DUF501; cl00652 675635002131 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635002132 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635002133 active site 675635002134 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 675635002135 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 675635002136 Fe-S cluster binding site [ion binding]; other site 675635002137 DNA binding site [nucleotide binding] 675635002138 active site 675635002139 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 675635002140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635002141 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 675635002142 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635002143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002144 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 675635002145 Helix-turn-helix domains; Region: HTH; cl00088 675635002146 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 675635002147 dimerization interface [polypeptide binding]; other site 675635002148 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 675635002149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635002150 Integrase core domain; Region: rve; cl01316 675635002151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635002152 Walker A motif; other site 675635002153 ATP binding site [chemical binding]; other site 675635002154 Walker B motif; other site 675635002155 arginine finger; other site 675635002156 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 675635002157 GAF domain; Region: GAF_2; pfam13185 675635002158 ANTAR domain; Region: ANTAR; cl04297 675635002159 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 675635002160 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635002161 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 675635002162 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635002163 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635002164 dimerization interface [polypeptide binding]; other site 675635002165 putative DNA binding site [nucleotide binding]; other site 675635002166 putative Zn2+ binding site [ion binding]; other site 675635002167 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 675635002168 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635002169 putative metal binding site [ion binding]; other site 675635002170 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 675635002171 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 675635002172 hexamer interface [polypeptide binding]; other site 675635002173 active site 675635002174 metal binding site [ion binding]; metal-binding site 675635002175 Protein of unknown function (DUF419); Region: DUF419; cl15265 675635002176 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 675635002177 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635002178 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635002179 Cupin domain; Region: Cupin_2; cl09118 675635002180 Helix-turn-helix domains; Region: HTH; cl00088 675635002181 classical (c) SDRs; Region: SDR_c; cd05233 675635002182 NAD(P) binding site [chemical binding]; other site 675635002183 active site 675635002184 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635002185 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635002186 active site 675635002187 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 675635002188 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 675635002189 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635002190 dimer interface [polypeptide binding]; other site 675635002191 active site 675635002192 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635002193 YCII-related domain; Region: YCII; cl00999 675635002194 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 675635002195 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635002196 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 675635002197 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635002198 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635002199 DNA binding residues [nucleotide binding] 675635002200 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 675635002201 FOG: WD40 repeat [General function prediction only]; Region: COG2319 675635002202 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 675635002203 structural tetrad; other site 675635002204 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 675635002205 structural tetrad; other site 675635002206 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 675635002207 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 675635002208 dimer interface [polypeptide binding]; other site 675635002209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635002210 catalytic residue [active] 675635002211 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 675635002212 cystathionine gamma-synthase; Provisional; Region: PRK07811 675635002213 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 675635002214 homodimer interface [polypeptide binding]; other site 675635002215 substrate-cofactor binding pocket; other site 675635002216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635002217 catalytic residue [active] 675635002218 threonine dehydratase; Provisional; Region: PRK08198 675635002219 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 675635002220 tetramer interface [polypeptide binding]; other site 675635002221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635002222 catalytic residue [active] 675635002223 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 675635002224 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 675635002225 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 675635002226 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 675635002227 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635002228 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 675635002229 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 675635002230 catalytic residues [active] 675635002231 Haemolysin-III related; Region: HlyIII; cl03831 675635002232 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 675635002233 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 675635002234 catalytic residue [active] 675635002235 putative FPP diphosphate binding site; other site 675635002236 putative FPP binding hydrophobic cleft; other site 675635002237 dimer interface [polypeptide binding]; other site 675635002238 putative IPP diphosphate binding site; other site 675635002239 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 675635002240 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 675635002241 putative active site [active] 675635002242 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002243 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 675635002244 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635002245 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 675635002246 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 675635002247 active site 675635002248 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 675635002249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002250 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 675635002251 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 675635002252 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 675635002253 active site 675635002254 DNA binding site [nucleotide binding] 675635002255 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 675635002256 DNA binding site [nucleotide binding] 675635002257 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 675635002258 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635002259 fumarate hydratase; Reviewed; Region: fumC; PRK00485 675635002260 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 675635002261 active sites [active] 675635002262 tetramer interface [polypeptide binding]; other site 675635002263 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 675635002264 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 675635002265 putative active site [active] 675635002266 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 675635002267 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 675635002268 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 675635002269 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 675635002270 generic binding surface II; other site 675635002271 generic binding surface I; other site 675635002272 LytB protein; Region: LYTB; cl00507 675635002273 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 675635002274 RmuC family; Region: RmuC; pfam02646 675635002275 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 675635002276 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 675635002277 DNA binding site [nucleotide binding] 675635002278 active site 675635002279 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 675635002280 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 675635002281 AlkA N-terminal domain; Region: AlkA_N; cl05528 675635002282 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 675635002283 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 675635002284 minor groove reading motif; other site 675635002285 helix-hairpin-helix signature motif; other site 675635002286 substrate binding pocket [chemical binding]; other site 675635002287 active site 675635002288 GTP-binding protein YchF; Reviewed; Region: PRK09601 675635002289 YchF GTPase; Region: YchF; cd01900 675635002290 G1 box; other site 675635002291 GTP/Mg2+ binding site [chemical binding]; other site 675635002292 Switch I region; other site 675635002293 G2 box; other site 675635002294 Switch II region; other site 675635002295 G3 box; other site 675635002296 G4 box; other site 675635002297 G5 box; other site 675635002298 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 675635002299 Predicted acyl esterases [General function prediction only]; Region: COG2936 675635002300 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 675635002301 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 675635002302 putative FMN binding site [chemical binding]; other site 675635002303 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635002304 Helix-turn-helix domains; Region: HTH; cl00088 675635002305 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635002306 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635002307 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 675635002308 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002309 Family description; Region: UvrD_C_2; cl15862 675635002310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635002311 putative DNA binding site [nucleotide binding]; other site 675635002312 dimerization interface [polypeptide binding]; other site 675635002313 putative Zn2+ binding site [ion binding]; other site 675635002314 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 675635002315 putative hydrophobic ligand binding site [chemical binding]; other site 675635002316 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 675635002317 putative hydrophobic ligand binding site [chemical binding]; other site 675635002318 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 675635002319 NeuB family; Region: NeuB; cl00496 675635002320 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 675635002321 CGNR zinc finger; Region: zf-CGNR; pfam11706 675635002322 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635002323 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 675635002324 putative dimer interface [polypeptide binding]; other site 675635002325 ligand binding site [chemical binding]; other site 675635002326 Zn binding site [ion binding]; other site 675635002327 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 675635002328 aromatic arch; other site 675635002329 DCoH dimer interaction site [polypeptide binding]; other site 675635002330 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 675635002331 DCoH tetramer interaction site [polypeptide binding]; other site 675635002332 substrate binding site [chemical binding]; other site 675635002333 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 675635002334 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002335 Walker A/P-loop; other site 675635002336 ATP binding site [chemical binding]; other site 675635002337 Q-loop/lid; other site 675635002338 ABC transporter signature motif; other site 675635002339 Walker B; other site 675635002340 D-loop; other site 675635002341 H-loop/switch region; other site 675635002342 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 675635002343 Transposase domain (DUF772); Region: DUF772; cl15789 675635002344 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635002345 Transposase domain (DUF772); Region: DUF772; cl15789 675635002346 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635002347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635002348 active site 675635002349 phosphorylation site [posttranslational modification] 675635002350 intermolecular recognition site; other site 675635002351 dimerization interface [polypeptide binding]; other site 675635002352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635002353 DNA binding site [nucleotide binding] 675635002354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635002355 dimer interface [polypeptide binding]; other site 675635002356 phosphorylation site [posttranslational modification] 675635002357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635002358 Mg2+ binding site [ion binding]; other site 675635002359 G-X-G motif; other site 675635002360 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635002361 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 675635002362 active site 675635002363 8-oxo-dGMP binding site [chemical binding]; other site 675635002364 nudix motif; other site 675635002365 metal binding site [ion binding]; metal-binding site 675635002366 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 675635002367 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 675635002368 G1 box; other site 675635002369 putative GEF interaction site [polypeptide binding]; other site 675635002370 GTP/Mg2+ binding site [chemical binding]; other site 675635002371 Switch I region; other site 675635002372 G2 box; other site 675635002373 G3 box; other site 675635002374 Switch II region; other site 675635002375 G4 box; other site 675635002376 G5 box; other site 675635002377 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 675635002378 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 675635002379 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 675635002380 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635002381 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635002382 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635002383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635002384 dimer interface [polypeptide binding]; other site 675635002385 conserved gate region; other site 675635002386 putative PBP binding loops; other site 675635002387 ABC-ATPase subunit interface; other site 675635002388 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 675635002389 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635002390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635002391 dimer interface [polypeptide binding]; other site 675635002392 conserved gate region; other site 675635002393 putative PBP binding loops; other site 675635002394 ABC-ATPase subunit interface; other site 675635002395 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 675635002396 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635002397 Walker A/P-loop; other site 675635002398 ATP binding site [chemical binding]; other site 675635002399 Q-loop/lid; other site 675635002400 ABC transporter signature motif; other site 675635002401 Walker B; other site 675635002402 D-loop; other site 675635002403 H-loop/switch region; other site 675635002404 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635002405 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635002406 Walker A/P-loop; other site 675635002407 ATP binding site [chemical binding]; other site 675635002408 Q-loop/lid; other site 675635002409 ABC transporter signature motif; other site 675635002410 Walker B; other site 675635002411 D-loop; other site 675635002412 H-loop/switch region; other site 675635002413 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635002414 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635002415 Ferredoxin [Energy production and conversion]; Region: COG1146 675635002416 4Fe-4S binding domain; Region: Fer4; cl02805 675635002417 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 675635002418 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635002419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635002420 homodimer interface [polypeptide binding]; other site 675635002421 catalytic residue [active] 675635002422 cyanate transporter; Region: CynX; TIGR00896 675635002423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635002424 putative substrate translocation pore; other site 675635002425 CHAD domain; Region: CHAD; cl10506 675635002426 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 675635002427 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 675635002428 putative trimer interface [polypeptide binding]; other site 675635002429 putative CoA binding site [chemical binding]; other site 675635002430 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 675635002431 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 675635002432 metal binding site [ion binding]; metal-binding site 675635002433 putative dimer interface [polypeptide binding]; other site 675635002434 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 675635002435 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 675635002436 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 675635002437 dihydropteroate synthase; Region: DHPS; TIGR01496 675635002438 substrate binding pocket [chemical binding]; other site 675635002439 dimer interface [polypeptide binding]; other site 675635002440 inhibitor binding site; inhibition site 675635002441 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 675635002442 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 675635002443 active site 675635002444 DivIVA domain; Region: DivI1A_domain; TIGR03544 675635002445 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 675635002446 hydrophobic ligand binding site; other site 675635002447 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 675635002448 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 675635002449 CGNR zinc finger; Region: zf-CGNR; pfam11706 675635002450 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 675635002451 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635002452 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 675635002453 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 675635002454 ligand binding site; other site 675635002455 oligomer interface; other site 675635002456 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 675635002457 dimer interface [polypeptide binding]; other site 675635002458 N-terminal domain interface [polypeptide binding]; other site 675635002459 sulfate 1 binding site; other site 675635002460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002461 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635002462 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635002463 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635002464 DNA binding residues [nucleotide binding] 675635002465 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 675635002466 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635002467 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 675635002468 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 675635002469 sec-independent translocase; Provisional; Region: tatB; PRK00404 675635002470 Alkylmercury lyase; Region: MerB; pfam03243 675635002471 putative amidase; Provisional; Region: PRK06169 675635002472 Amidase; Region: Amidase; cl11426 675635002473 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 675635002474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002475 Cyclophilin-like; Region: Cyclophil_like; cl00950 675635002476 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 675635002477 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 675635002478 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 675635002479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635002480 DNA-binding site [nucleotide binding]; DNA binding site 675635002481 FCD domain; Region: FCD; cl11656 675635002482 Membrane transport protein; Region: Mem_trans; cl09117 675635002483 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 675635002484 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635002485 inhibitor-cofactor binding pocket; inhibition site 675635002486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635002487 catalytic residue [active] 675635002488 antiporter inner membrane protein; Provisional; Region: PRK11670 675635002489 Domain of unknown function DUF59; Region: DUF59; cl00941 675635002490 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 675635002491 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635002492 Helix-turn-helix domains; Region: HTH; cl00088 675635002493 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 675635002494 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 675635002495 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 675635002496 MgtE intracellular N domain; Region: MgtE_N; cl15244 675635002497 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 675635002498 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 675635002499 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 675635002500 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 675635002501 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635002502 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635002503 active site 675635002504 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635002505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635002506 dimer interface [polypeptide binding]; other site 675635002507 conserved gate region; other site 675635002508 putative PBP binding loops; other site 675635002509 ABC-ATPase subunit interface; other site 675635002510 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 675635002511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635002512 dimer interface [polypeptide binding]; other site 675635002513 conserved gate region; other site 675635002514 putative PBP binding loops; other site 675635002515 ABC-ATPase subunit interface; other site 675635002516 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 675635002517 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 675635002518 Walker A/P-loop; other site 675635002519 ATP binding site [chemical binding]; other site 675635002520 Q-loop/lid; other site 675635002521 ABC transporter signature motif; other site 675635002522 Walker B; other site 675635002523 D-loop; other site 675635002524 H-loop/switch region; other site 675635002525 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635002526 DNA-binding site [nucleotide binding]; DNA binding site 675635002527 D-cysteine desulfhydrase; Validated; Region: PRK03910 675635002528 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 675635002529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635002530 catalytic residue [active] 675635002531 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635002532 Helix-turn-helix domains; Region: HTH; cl00088 675635002533 Integrase core domain; Region: rve; cl01316 675635002534 ParB-like nuclease domain; Region: ParBc; cl02129 675635002535 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 675635002536 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 675635002537 active site 675635002538 metal binding site [ion binding]; metal-binding site 675635002539 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 675635002540 Methyltransferase domain; Region: Methyltransf_31; pfam13847 675635002541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635002542 S-adenosylmethionine binding site [chemical binding]; other site 675635002543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002544 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 675635002545 iron-sulfur cluster [ion binding]; other site 675635002546 [2Fe-2S] cluster binding site [ion binding]; other site 675635002547 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 675635002548 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 675635002549 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 675635002550 putative active site [active] 675635002551 putative catalytic site [active] 675635002552 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635002553 nudix motif; other site 675635002554 Bacterial PH domain; Region: DUF304; cl01348 675635002555 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 675635002556 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 675635002557 helicase 45; Provisional; Region: PTZ00424 675635002558 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 675635002559 ATP binding site [chemical binding]; other site 675635002560 Mg++ binding site [ion binding]; other site 675635002561 motif III; other site 675635002562 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635002563 nucleotide binding region [chemical binding]; other site 675635002564 ATP-binding site [chemical binding]; other site 675635002565 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 675635002566 dinuclear metal binding motif [ion binding]; other site 675635002567 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 675635002568 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 675635002569 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 675635002570 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 675635002571 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 675635002572 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 675635002573 ABC-2 type transporter; Region: ABC2_membrane; cl11417 675635002574 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 675635002575 Walker A/P-loop; other site 675635002576 ATP binding site [chemical binding]; other site 675635002577 Q-loop/lid; other site 675635002578 ABC transporter signature motif; other site 675635002579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635002580 Helix-turn-helix domains; Region: HTH; cl00088 675635002581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002582 NAD(P) binding site [chemical binding]; other site 675635002583 active site 675635002584 short chain dehydrogenase; Provisional; Region: PRK07825 675635002585 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635002586 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635002587 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635002588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635002589 Helix-turn-helix domains; Region: HTH; cl00088 675635002590 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 675635002591 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635002592 metal-binding site [ion binding] 675635002593 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635002594 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635002595 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635002596 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635002597 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 675635002598 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 675635002599 ATP binding site [chemical binding]; other site 675635002600 substrate interface [chemical binding]; other site 675635002601 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635002602 active site residue [active] 675635002603 TIGR02569 family protein; Region: TIGR02569_actnb 675635002604 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 675635002605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635002606 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 675635002607 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 675635002608 [4Fe-4S] binding site [ion binding]; other site 675635002609 molybdopterin cofactor binding site; other site 675635002610 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 675635002611 molybdopterin cofactor binding site; other site 675635002612 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 675635002613 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 675635002614 nitrite reductase subunit NirD; Provisional; Region: PRK14989 675635002615 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 675635002616 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 675635002617 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 675635002618 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 675635002619 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 675635002620 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 675635002621 active site 675635002622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635002623 DNA binding site [nucleotide binding] 675635002624 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 675635002625 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 675635002626 putative active site [active] 675635002627 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 675635002628 active site 675635002629 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 675635002630 active site 675635002631 DNA binding site [nucleotide binding] 675635002632 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635002633 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635002634 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635002635 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 675635002636 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 675635002637 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 675635002638 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 675635002639 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 675635002640 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002641 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 675635002642 DoxX; Region: DoxX; cl00976 675635002643 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635002644 Helix-turn-helix domains; Region: HTH; cl00088 675635002645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002646 Uncharacterized conserved protein [Function unknown]; Region: COG3268 675635002647 NAD(P) binding site [chemical binding]; other site 675635002648 Ion channel; Region: Ion_trans_2; cl11596 675635002649 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 675635002650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002651 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 675635002652 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 675635002653 N- and C-terminal domain interface [polypeptide binding]; other site 675635002654 D-xylulose kinase; Region: XylB; TIGR01312 675635002655 active site 675635002656 MgATP binding site [chemical binding]; other site 675635002657 catalytic site [active] 675635002658 metal binding site [ion binding]; metal-binding site 675635002659 carbohydrate binding site [chemical binding]; other site 675635002660 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 675635002661 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 675635002662 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 675635002663 putative catalytic site [active] 675635002664 putative phosphate binding site [ion binding]; other site 675635002665 active site 675635002666 metal binding site A [ion binding]; metal-binding site 675635002667 DNA binding site [nucleotide binding] 675635002668 putative AP binding site [nucleotide binding]; other site 675635002669 putative metal binding site B [ion binding]; other site 675635002670 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 675635002671 active site 675635002672 putative catalytic site [active] 675635002673 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 675635002674 NAD(P) binding site [chemical binding]; other site 675635002675 catalytic residues [active] 675635002676 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635002677 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 675635002678 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 675635002679 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 675635002680 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 675635002681 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 675635002682 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 675635002683 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 675635002684 putative NADH binding site [chemical binding]; other site 675635002685 putative active site [active] 675635002686 nudix motif; other site 675635002687 putative metal binding site [ion binding]; other site 675635002688 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 675635002689 catalytic residues [active] 675635002690 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 675635002691 Family description; Region: UvrD_C_2; cl15862 675635002692 HRDC domain; Region: HRDC; cl02578 675635002693 Transcription factor WhiB; Region: Whib; pfam02467 675635002694 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 675635002695 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635002696 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 675635002697 active site 675635002698 ATP binding site [chemical binding]; other site 675635002699 Protein of unknown function DUF45; Region: DUF45; cl00636 675635002700 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 675635002701 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 675635002702 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 675635002703 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635002704 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 675635002705 Int/Topo IB signature motif; other site 675635002706 AAA domain; Region: AAA_25; pfam13481 675635002707 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002708 Walker A motif; other site 675635002709 ATP binding site [chemical binding]; other site 675635002710 Walker B motif; other site 675635002711 Helix-turn-helix domains; Region: HTH; cl00088 675635002712 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 675635002713 polymerase nucleotide-binding site; other site 675635002714 DNA-binding residues [nucleotide binding]; DNA binding site 675635002715 nucleotide binding site [chemical binding]; other site 675635002716 primase nucleotide-binding site [nucleotide binding]; other site 675635002717 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002718 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 675635002719 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 675635002720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635002721 DNA-binding site [nucleotide binding]; DNA binding site 675635002722 AAA domain; Region: AAA_33; pfam13671 675635002723 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002725 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 675635002726 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 675635002727 synthetase active site [active] 675635002728 NTP binding site [chemical binding]; other site 675635002729 metal binding site [ion binding]; metal-binding site 675635002730 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 675635002731 Ion channel; Region: Ion_trans_2; cl11596 675635002732 Membrane transport protein; Region: Mem_trans; cl09117 675635002733 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635002734 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 675635002735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635002736 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 675635002737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635002738 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 675635002739 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635002740 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635002741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635002742 Integrase core domain; Region: rve; cl01316 675635002743 transposase/IS protein; Provisional; Region: PRK09183 675635002744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635002745 Walker A motif; other site 675635002746 ATP binding site [chemical binding]; other site 675635002747 Walker B motif; other site 675635002748 arginine finger; other site 675635002749 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 675635002750 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 675635002751 conserved cys residue [active] 675635002752 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635002753 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635002754 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635002755 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 675635002756 tetramerization interface [polypeptide binding]; other site 675635002757 NAD(P) binding site [chemical binding]; other site 675635002758 catalytic residues [active] 675635002759 Sodium:solute symporter family; Region: SSF; cl00456 675635002760 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635002761 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635002762 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 675635002763 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635002764 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635002765 dinuclear metal binding motif [ion binding]; other site 675635002766 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 675635002767 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 675635002768 [2Fe-2S] cluster binding site [ion binding]; other site 675635002769 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635002770 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 675635002771 dimerization interface [polypeptide binding]; other site 675635002772 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 675635002773 Helix-turn-helix domains; Region: HTH; cl00088 675635002774 Helix-turn-helix domains; Region: HTH; cl00088 675635002775 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635002776 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 675635002777 NADP binding site [chemical binding]; other site 675635002778 substrate binding site [chemical binding]; other site 675635002779 active site 675635002780 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635002781 dimerization interface [polypeptide binding]; other site 675635002782 putative DNA binding site [nucleotide binding]; other site 675635002783 putative Zn2+ binding site [ion binding]; other site 675635002784 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635002785 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 675635002786 Plant ATP synthase F0; Region: YMF19; cl07975 675635002787 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 675635002788 short chain dehydrogenase; Provisional; Region: PRK05650 675635002789 classical (c) SDRs; Region: SDR_c; cd05233 675635002790 NAD(P) binding site [chemical binding]; other site 675635002791 active site 675635002792 Bacterial transcriptional activator domain; Region: BTAD; smart01043 675635002793 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 675635002794 OpgC protein; Region: OpgC_C; cl00792 675635002795 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 675635002796 N-acetyl-D-glucosamine binding site [chemical binding]; other site 675635002797 catalytic residue [active] 675635002798 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 675635002799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002800 NAD(P) binding site [chemical binding]; other site 675635002801 active site 675635002802 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635002803 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 675635002804 DNA binding residues [nucleotide binding] 675635002805 NIPSNAP; Region: NIPSNAP; pfam07978 675635002806 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 675635002807 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 675635002808 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 675635002809 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 675635002810 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635002811 active site 675635002812 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 675635002813 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635002814 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635002815 active site 675635002816 Helix-turn-helix domains; Region: HTH; cl00088 675635002817 peptide chain release factor 2; Validated; Region: prfB; PRK00578 675635002818 RF-1 domain; Region: RF-1; cl02875 675635002819 RF-1 domain; Region: RF-1; cl02875 675635002820 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 675635002821 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002822 Walker A/P-loop; other site 675635002823 ATP binding site [chemical binding]; other site 675635002824 Q-loop/lid; other site 675635002825 ABC transporter signature motif; other site 675635002826 Walker B; other site 675635002827 D-loop; other site 675635002828 H-loop/switch region; other site 675635002829 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 675635002830 FtsX-like permease family; Region: FtsX; cl15850 675635002831 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 675635002832 SmpB-tmRNA interface; other site 675635002833 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 675635002834 active site 675635002835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635002836 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635002837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635002838 putative substrate translocation pore; other site 675635002839 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 675635002840 Isochorismatase family; Region: Isochorismatase; pfam00857 675635002841 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 675635002842 catalytic triad [active] 675635002843 conserved cis-peptide bond; other site 675635002844 Isochorismatase family; Region: Isochorismatase; pfam00857 675635002845 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 675635002846 catalytic triad [active] 675635002847 conserved cis-peptide bond; other site 675635002848 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635002849 Amidase; Region: Amidase; cl11426 675635002850 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635002851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635002852 DNA-binding site [nucleotide binding]; DNA binding site 675635002853 FCD domain; Region: FCD; cl11656 675635002854 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 675635002855 Transposase domain (DUF772); Region: DUF772; cl15789 675635002856 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635002857 Transposase domain (DUF772); Region: DUF772; cl15789 675635002858 DoxX; Region: DoxX; cl00976 675635002859 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635002860 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 675635002861 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 675635002862 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 675635002863 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635002864 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635002865 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635002866 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 675635002867 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 675635002868 catalytic residues [active] 675635002869 catalytic nucleophile [active] 675635002870 Recombinase; Region: Recombinase; pfam07508 675635002871 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 675635002872 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 675635002873 catalytic nucleophile [active] 675635002874 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 675635002875 Presynaptic Site I dimer interface [polypeptide binding]; other site 675635002876 catalytic residues [active] 675635002877 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 675635002878 Synaptic Flat tetramer interface [polypeptide binding]; other site 675635002879 Synaptic Site I dimer interface [polypeptide binding]; other site 675635002880 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635002881 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 675635002882 Recombinase; Region: Recombinase; pfam07508 675635002883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002884 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635002885 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635002886 PrgI family protein; Region: PrgI; pfam12666 675635002887 AAA-like domain; Region: AAA_10; pfam12846 675635002888 Domain of unknown function DUF87; Region: DUF87; pfam01935 675635002889 Domain of unknown function DUF87; Region: DUF87; pfam01935 675635002890 AAA-like domain; Region: AAA_10; pfam12846 675635002891 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 675635002892 Replication-relaxation; Region: Replic_Relax; pfam13814 675635002893 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 675635002894 N-acetyl-D-glucosamine binding site [chemical binding]; other site 675635002895 catalytic residue [active] 675635002896 NlpC/P60 family; Region: NLPC_P60; cl11438 675635002897 Protein of unknown function DUF45; Region: DUF45; cl00636 675635002898 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 675635002899 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 675635002900 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 675635002901 Active Sites [active] 675635002902 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 675635002903 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 675635002904 substrate binding site [chemical binding]; other site 675635002905 hexamer interface [polypeptide binding]; other site 675635002906 metal binding site [ion binding]; metal-binding site 675635002907 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 675635002908 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635002909 motif II; other site 675635002910 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 675635002911 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002912 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 675635002913 active site 675635002914 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 675635002915 thymidylate kinase; Validated; Region: tmk; PRK00698 675635002916 TMP-binding site; other site 675635002917 ATP-binding site [chemical binding]; other site 675635002918 Phosphotransferase enzyme family; Region: APH; pfam01636 675635002919 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635002920 active site 675635002921 ATP binding site [chemical binding]; other site 675635002922 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635002923 Divergent AAA domain; Region: AAA_4; pfam04326 675635002924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635002925 Integrase core domain; Region: rve; cl01316 675635002926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635002927 Walker A motif; other site 675635002928 ATP binding site [chemical binding]; other site 675635002929 Walker B motif; other site 675635002930 arginine finger; other site 675635002931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635002932 ATP binding site [chemical binding]; other site 675635002933 putative Mg++ binding site [ion binding]; other site 675635002934 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635002935 Putative zinc-finger; Region: zf-HC2; cl15806 675635002936 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635002937 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635002938 DNA binding residues [nucleotide binding] 675635002939 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 675635002940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635002941 FeS/SAM binding site; other site 675635002942 Methyltransferase domain; Region: Methyltransf_31; pfam13847 675635002943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635002944 S-adenosylmethionine binding site [chemical binding]; other site 675635002945 Domain of unknown function (DUF427); Region: DUF427; cl00998 675635002946 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 675635002947 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 675635002948 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 675635002949 catalytic residues [active] 675635002950 Domain of unknown function (DUF427); Region: DUF427; cl00998 675635002951 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 675635002952 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635002953 ligand binding site [chemical binding]; other site 675635002954 flexible hinge region; other site 675635002955 Helix-turn-helix domains; Region: HTH; cl00088 675635002956 mercuric reductase; Validated; Region: PRK06370 675635002957 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635002958 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635002959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002960 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635002961 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 675635002962 Phosphate transporter family; Region: PHO4; cl00396 675635002963 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635002964 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 675635002965 ligand binding site [chemical binding]; other site 675635002966 flexible hinge region; other site 675635002967 Helix-turn-helix domains; Region: HTH; cl00088 675635002968 Domain of unknown function DUF302; Region: DUF302; cl01364 675635002969 Domain of unknown function DUF302; Region: DUF302; cl01364 675635002970 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635002971 metal-binding site [ion binding] 675635002972 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 675635002973 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635002974 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635002975 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635002976 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635002977 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635002978 metal-binding site [ion binding] 675635002979 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635002980 DNA binding residues [nucleotide binding] 675635002981 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 675635002982 putative catalytic residues [active] 675635002983 mercuric reductase; Validated; Region: PRK06370 675635002984 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635002985 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635002986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635002987 Helix-turn-helix domains; Region: HTH; cl00088 675635002988 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 675635002989 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 675635002990 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635002991 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 675635002992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635002993 motif II; other site 675635002994 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 675635002995 catalytic residues [active] 675635002996 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 675635002997 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 675635002998 catalytic residues [active] 675635002999 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 675635003000 putative homodimer interface [polypeptide binding]; other site 675635003001 putative homotetramer interface [polypeptide binding]; other site 675635003002 allosteric switch controlling residues; other site 675635003003 putative metal binding site [ion binding]; other site 675635003004 putative homodimer-homodimer interface [polypeptide binding]; other site 675635003005 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 675635003006 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635003007 metal-binding site [ion binding] 675635003008 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635003009 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635003010 Putative zinc-finger; Region: zf-HC2; cl15806 675635003011 RNA polymerase sigma factor; Provisional; Region: PRK12533 675635003012 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635003013 DNA binding residues [nucleotide binding] 675635003014 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635003015 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635003016 DNA binding residues [nucleotide binding] 675635003017 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 675635003018 Alkylmercury lyase; Region: MerB; pfam03243 675635003019 alkylmercury lyase; Provisional; Region: PRK13239 675635003020 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 675635003021 Alkylmercury lyase; Region: MerB; pfam03243 675635003022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635003023 dimerization interface [polypeptide binding]; other site 675635003024 putative DNA binding site [nucleotide binding]; other site 675635003025 putative Zn2+ binding site [ion binding]; other site 675635003026 mercuric reductase; Region: MerA; TIGR02053 675635003027 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635003028 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635003029 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635003030 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635003031 DNA binding residues [nucleotide binding] 675635003032 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635003033 nudix motif; other site 675635003034 Helix-turn-helix domains; Region: HTH; cl00088 675635003035 DNA-binding interface [nucleotide binding]; DNA binding site 675635003036 Helix-turn-helix domains; Region: HTH; cl00088 675635003037 DNA-binding interface [nucleotide binding]; DNA binding site 675635003038 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 675635003039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635003040 non-specific DNA binding site [nucleotide binding]; other site 675635003041 salt bridge; other site 675635003042 sequence-specific DNA binding site [nucleotide binding]; other site 675635003043 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 675635003044 FMN binding site [chemical binding]; other site 675635003045 dimer interface [polypeptide binding]; other site 675635003046 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 675635003047 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635003048 active site 675635003049 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 675635003050 AMP-binding enzyme; Region: AMP-binding; cl15778 675635003051 GAF domain; Region: GAF; cl15785 675635003052 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 675635003053 Helix-turn-helix domains; Region: HTH; cl00088 675635003054 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 675635003055 dimer interface [polypeptide binding]; other site 675635003056 phosphate binding site [ion binding]; other site 675635003057 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635003058 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635003059 active site 675635003060 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 675635003061 dimer interface [polypeptide binding]; other site 675635003062 non-prolyl cis peptide bond; other site 675635003063 insertion regions; other site 675635003064 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 675635003065 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635003066 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635003067 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 675635003068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003069 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 675635003070 dihydrodipicolinate synthase; Region: dapA; TIGR00674 675635003071 dimer interface [polypeptide binding]; other site 675635003072 active site 675635003073 catalytic residue [active] 675635003074 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 675635003075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635003076 Helix-turn-helix domains; Region: HTH; cl00088 675635003077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 675635003078 dimerization interface [polypeptide binding]; other site 675635003079 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 675635003080 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635003081 putative NAD(P) binding site [chemical binding]; other site 675635003082 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635003083 Helix-turn-helix domains; Region: HTH; cl00088 675635003084 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 675635003085 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 675635003086 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635003087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635003088 DNA-binding site [nucleotide binding]; DNA binding site 675635003089 FCD domain; Region: FCD; cl11656 675635003090 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635003091 AMP-binding enzyme; Region: AMP-binding; cl15778 675635003092 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635003093 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635003094 substrate binding site [chemical binding]; other site 675635003095 oxyanion hole (OAH) forming residues; other site 675635003096 trimer interface [polypeptide binding]; other site 675635003097 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635003098 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635003099 active site 675635003100 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635003101 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635003102 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635003103 active site 675635003104 Putative cyclase; Region: Cyclase; cl00814 675635003105 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635003106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635003107 DNA-binding site [nucleotide binding]; DNA binding site 675635003108 FCD domain; Region: FCD; cl11656 675635003109 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635003110 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635003111 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635003112 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635003113 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635003114 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003115 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 675635003116 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635003117 Walker A/P-loop; other site 675635003118 ATP binding site [chemical binding]; other site 675635003119 Q-loop/lid; other site 675635003120 ABC transporter signature motif; other site 675635003121 Walker B; other site 675635003122 D-loop; other site 675635003123 H-loop/switch region; other site 675635003124 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635003125 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635003126 Walker A/P-loop; other site 675635003127 ATP binding site [chemical binding]; other site 675635003128 Q-loop/lid; other site 675635003129 ABC transporter signature motif; other site 675635003130 Walker B; other site 675635003131 D-loop; other site 675635003132 H-loop/switch region; other site 675635003133 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635003134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635003135 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635003136 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 675635003137 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635003138 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635003139 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635003140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003141 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 675635003142 NAD(P) binding site [chemical binding]; other site 675635003143 active site 675635003144 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635003145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635003146 DNA-binding site [nucleotide binding]; DNA binding site 675635003147 FCD domain; Region: FCD; cl11656 675635003148 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 675635003149 dimer interface [polypeptide binding]; other site 675635003150 putative functional site; other site 675635003151 putative MPT binding site; other site 675635003152 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 675635003153 FMN binding site [chemical binding]; other site 675635003154 dimer interface [polypeptide binding]; other site 675635003155 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635003156 classical (c) SDRs; Region: SDR_c; cd05233 675635003157 NAD(P) binding site [chemical binding]; other site 675635003158 active site 675635003159 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635003160 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635003161 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635003162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003163 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 675635003164 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 675635003165 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 675635003166 dimerization interface [polypeptide binding]; other site 675635003167 active site 675635003168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003169 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635003170 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003171 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635003172 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003173 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 675635003174 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003175 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635003176 Transcriptional regulators [Transcription]; Region: PurR; COG1609 675635003177 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 675635003178 DNA binding site [nucleotide binding] 675635003179 domain linker motif; other site 675635003180 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 675635003181 dimerization interface [polypeptide binding]; other site 675635003182 ligand binding site [chemical binding]; other site 675635003183 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635003185 Helix-turn-helix domains; Region: HTH; cl00088 675635003186 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 675635003187 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635003188 molybdopterin cofactor binding site; other site 675635003189 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 675635003190 molybdopterin cofactor binding site; other site 675635003191 Epoxide hydrolase N terminus; Region: EHN; pfam06441 675635003192 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635003193 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 675635003194 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635003195 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635003196 TM-ABC transporter signature motif; other site 675635003197 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635003198 TM-ABC transporter signature motif; other site 675635003199 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635003200 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 675635003201 Walker A/P-loop; other site 675635003202 ATP binding site [chemical binding]; other site 675635003203 Q-loop/lid; other site 675635003204 ABC transporter signature motif; other site 675635003205 Walker B; other site 675635003206 D-loop; other site 675635003207 H-loop/switch region; other site 675635003208 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635003209 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 675635003210 Walker A/P-loop; other site 675635003211 ATP binding site [chemical binding]; other site 675635003212 Q-loop/lid; other site 675635003213 ABC transporter signature motif; other site 675635003214 Walker B; other site 675635003215 D-loop; other site 675635003216 H-loop/switch region; other site 675635003217 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 675635003218 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003219 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635003220 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635003221 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635003222 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635003223 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635003224 thiolase; Provisional; Region: PRK06158 675635003225 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635003226 active site 675635003227 choline dehydrogenase; Validated; Region: PRK02106 675635003228 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 675635003229 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635003230 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 675635003231 NAD(P) binding site [chemical binding]; other site 675635003232 catalytic residues [active] 675635003233 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635003234 active site 675635003235 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635003236 metal binding site [ion binding]; metal-binding site 675635003237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635003238 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635003239 putative substrate translocation pore; other site 675635003240 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635003241 Helix-turn-helix domains; Region: HTH; cl00088 675635003242 Winged helix-turn helix; Region: HTH_29; pfam13551 675635003243 Helix-turn-helix domains; Region: HTH; cl00088 675635003244 Integrase core domain; Region: rve; cl01316 675635003245 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 675635003246 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 675635003247 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635003248 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635003249 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 675635003250 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635003251 Winged helix-turn helix; Region: HTH_29; pfam13551 675635003252 Helix-turn-helix domains; Region: HTH; cl00088 675635003253 Integrase core domain; Region: rve; cl01316 675635003254 Lsr2; Region: Lsr2; pfam11774 675635003255 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 675635003256 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 675635003257 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 675635003258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003259 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 675635003260 putative NAD(P) binding site [chemical binding]; other site 675635003261 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 675635003262 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635003263 Sulfatase; Region: Sulfatase; cl10460 675635003264 Helix-turn-helix domains; Region: HTH; cl00088 675635003265 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 675635003266 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 675635003267 dimer interface [polypeptide binding]; other site 675635003268 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 675635003269 active site 675635003270 Fe binding site [ion binding]; other site 675635003271 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 675635003272 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635003273 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635003274 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635003275 active site 675635003276 metal binding site [ion binding]; metal-binding site 675635003277 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 675635003278 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635003279 hydrophobic ligand binding site; other site 675635003280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635003281 Helix-turn-helix domains; Region: HTH; cl00088 675635003282 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 675635003283 substrate binding pocket [chemical binding]; other site 675635003284 dimerization interface [polypeptide binding]; other site 675635003285 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635003286 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635003287 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 675635003288 active site 675635003289 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 675635003290 AMP binding site [chemical binding]; other site 675635003291 metal binding site [ion binding]; metal-binding site 675635003292 active site 675635003293 Amidase; Region: Amidase; cl11426 675635003294 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 675635003295 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 675635003296 metal binding site 2 [ion binding]; metal-binding site 675635003297 putative DNA binding helix; other site 675635003298 metal binding site 1 [ion binding]; metal-binding site 675635003299 dimer interface [polypeptide binding]; other site 675635003300 structural Zn2+ binding site [ion binding]; other site 675635003301 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 675635003302 Ferritin-like domain; Region: Ferritin; pfam00210 675635003303 dimerization interface [polypeptide binding]; other site 675635003304 DPS ferroxidase diiron center [ion binding]; other site 675635003305 ion pore; other site 675635003306 Helix-turn-helix domains; Region: HTH; cl00088 675635003307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635003308 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 675635003309 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 675635003310 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 675635003311 tetramer interface [polypeptide binding]; other site 675635003312 active site 675635003313 Mg2+/Mn2+ binding site [ion binding]; other site 675635003314 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 675635003315 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 675635003316 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 675635003317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635003318 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635003319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635003320 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 675635003321 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 675635003322 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 675635003323 potential catalytic triad [active] 675635003324 conserved cys residue [active] 675635003325 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635003326 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635003327 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635003328 dinuclear metal binding motif [ion binding]; other site 675635003329 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 675635003330 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635003331 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635003332 dinuclear metal binding motif [ion binding]; other site 675635003333 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 675635003334 [2Fe-2S] cluster binding site [ion binding]; other site 675635003335 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 675635003336 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635003337 Domain of unknown function DUF59; Region: DUF59; cl00941 675635003338 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 675635003339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635003340 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 675635003341 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 675635003342 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 675635003343 hypothetical protein; Provisional; Region: PRK05858 675635003344 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635003345 PYR/PP interface [polypeptide binding]; other site 675635003346 dimer interface [polypeptide binding]; other site 675635003347 TPP binding site [chemical binding]; other site 675635003348 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 675635003349 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635003350 TPP-binding site [chemical binding]; other site 675635003351 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635003352 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 675635003353 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 675635003354 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 675635003355 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 675635003356 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635003357 Amidase; Region: Amidase; cl11426 675635003358 amidohydrolase, AtzE family; Region: amido_AtzE; TIGR02715 675635003359 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 675635003360 putative dimer interface [polypeptide binding]; other site 675635003361 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635003362 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 675635003363 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635003364 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635003365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635003366 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635003367 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635003368 classical (c) SDRs; Region: SDR_c; cd05233 675635003369 NAD(P) binding site [chemical binding]; other site 675635003370 active site 675635003371 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 675635003372 classical (c) SDRs; Region: SDR_c; cd05233 675635003373 NAD(P) binding site [chemical binding]; other site 675635003374 active site 675635003375 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635003376 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635003377 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635003378 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635003379 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635003380 Helix-turn-helix domains; Region: HTH; cl00088 675635003381 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 675635003382 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 675635003383 dimer interface [polypeptide binding]; other site 675635003384 PYR/PP interface [polypeptide binding]; other site 675635003385 TPP binding site [chemical binding]; other site 675635003386 substrate binding site [chemical binding]; other site 675635003387 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635003388 TPP-binding site [chemical binding]; other site 675635003389 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 675635003390 FAD binding domain; Region: FAD_binding_2; pfam00890 675635003391 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 675635003392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635003393 DNA binding residues [nucleotide binding] 675635003394 dimerization interface [polypeptide binding]; other site 675635003395 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 675635003396 homotrimer interaction site [polypeptide binding]; other site 675635003397 putative active site [active] 675635003398 FAD binding domain; Region: FAD_binding_4; pfam01565 675635003399 Cupin domain; Region: Cupin_2; cl09118 675635003400 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 675635003401 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003402 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635003403 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635003404 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 675635003405 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003406 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 675635003407 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003408 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635003409 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635003410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003411 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635003412 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 675635003413 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 675635003414 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635003415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003416 NAD(P) binding site [chemical binding]; other site 675635003417 active site 675635003418 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 675635003419 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 675635003420 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 675635003421 conserved cys residue [active] 675635003422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635003423 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635003424 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635003425 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635003426 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 675635003427 active site 675635003428 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635003429 classical (c) SDRs; Region: SDR_c; cd05233 675635003430 NAD(P) binding site [chemical binding]; other site 675635003431 active site 675635003432 Predicted transcriptional regulators [Transcription]; Region: COG1378 675635003433 Helix-turn-helix domains; Region: HTH; cl00088 675635003434 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 675635003435 C-terminal domain interface [polypeptide binding]; other site 675635003436 sugar binding site [chemical binding]; other site 675635003437 D-galactonate transporter; Region: 2A0114; TIGR00893 675635003438 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 675635003439 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 675635003440 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 675635003441 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635003442 substrate binding site [chemical binding]; other site 675635003443 oxyanion hole (OAH) forming residues; other site 675635003444 trimer interface [polypeptide binding]; other site 675635003445 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635003446 substrate binding site [chemical binding]; other site 675635003447 trimer interface [polypeptide binding]; other site 675635003448 oxyanion hole (OAH) forming residues; other site 675635003449 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 675635003450 AMP-binding enzyme; Region: AMP-binding; cl15778 675635003451 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635003452 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 675635003453 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 675635003454 NAD binding site [chemical binding]; other site 675635003455 catalytic Zn binding site [ion binding]; other site 675635003456 substrate binding site [chemical binding]; other site 675635003457 structural Zn binding site [ion binding]; other site 675635003458 MoxR-like ATPases [General function prediction only]; Region: COG0714 675635003459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635003460 Walker A motif; other site 675635003461 ATP binding site [chemical binding]; other site 675635003462 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635003463 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 675635003464 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 675635003465 D-pathway; other site 675635003466 Putative ubiquinol binding site [chemical binding]; other site 675635003467 Low-spin heme (heme b) binding site [chemical binding]; other site 675635003468 Putative water exit pathway; other site 675635003469 Binuclear center (heme o3/CuB) [ion binding]; other site 675635003470 K-pathway; other site 675635003471 Putative proton exit pathway; other site 675635003472 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 675635003473 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 675635003474 phosphoserine phosphatase SerB; Region: serB; TIGR00338 675635003475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635003476 motif II; other site 675635003477 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 675635003478 dimer interface [polypeptide binding]; other site 675635003479 putative active site [active] 675635003480 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635003481 nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323 675635003482 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 675635003483 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635003484 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 675635003485 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 675635003486 conserved cys residue [active] 675635003487 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 675635003488 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 675635003489 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635003490 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635003491 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635003492 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635003493 active site 2 [active] 675635003494 active site 1 [active] 675635003495 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 675635003496 Isochorismatase family; Region: Isochorismatase; pfam00857 675635003497 catalytic triad [active] 675635003498 metal binding site [ion binding]; metal-binding site 675635003499 conserved cis-peptide bond; other site 675635003500 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 675635003501 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 675635003502 active site 675635003503 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 675635003504 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 675635003505 Rdx family; Region: Rdx; cl01407 675635003506 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 675635003507 MPN+ (JAMM) motif; other site 675635003508 Zinc-binding site [ion binding]; other site 675635003509 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 675635003510 MoaE interaction surface [polypeptide binding]; other site 675635003511 MoeB interaction surface [polypeptide binding]; other site 675635003512 thiocarboxylated glycine; other site 675635003513 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 675635003514 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 675635003515 dimer interface [polypeptide binding]; other site 675635003516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635003517 catalytic residue [active] 675635003518 Rhomboid family; Region: Rhomboid; cl11446 675635003519 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 675635003520 Transposase domain (DUF772); Region: DUF772; cl15789 675635003521 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635003522 Transposase domain (DUF772); Region: DUF772; cl15789 675635003523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635003524 ribonuclease PH; Reviewed; Region: rph; PRK00173 675635003525 Ribonuclease PH; Region: RNase_PH_bact; cd11362 675635003526 hexamer interface [polypeptide binding]; other site 675635003527 active site 675635003528 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 675635003529 active site 675635003530 dimerization interface [polypeptide binding]; other site 675635003531 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635003532 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 675635003533 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 675635003534 catalytic triad [active] 675635003535 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 675635003536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 675635003537 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635003538 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 675635003539 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635003540 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635003541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635003542 DNA binding residues [nucleotide binding] 675635003543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635003544 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635003545 Transcription factor WhiB; Region: Whib; pfam02467 675635003546 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635003547 anti sigma factor interaction site; other site 675635003548 regulatory phosphorylation site [posttranslational modification]; other site 675635003549 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 675635003550 G1 box; other site 675635003551 putative GEF interaction site [polypeptide binding]; other site 675635003552 GTP/Mg2+ binding site [chemical binding]; other site 675635003553 Switch I region; other site 675635003554 G2 box; other site 675635003555 G3 box; other site 675635003556 Switch II region; other site 675635003557 G4 box; other site 675635003558 G5 box; other site 675635003559 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 675635003560 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 675635003561 selenocysteine synthase; Provisional; Region: PRK04311 675635003562 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 675635003563 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635003564 selenophosphate synthetase; Provisional; Region: PRK00943 675635003565 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 675635003566 dimerization interface [polypeptide binding]; other site 675635003567 putative ATP binding site [chemical binding]; other site 675635003568 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635003569 Transposase domain (DUF772); Region: DUF772; cl15789 675635003570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635003571 S-adenosylmethionine binding site [chemical binding]; other site 675635003572 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635003573 Amidase; Region: Amidase; cl11426 675635003574 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635003575 anti sigma factor interaction site; other site 675635003576 regulatory phosphorylation site [posttranslational modification]; other site 675635003577 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635003578 dinuclear metal binding motif [ion binding]; other site 675635003579 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 675635003580 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 675635003581 Walker A/P-loop; other site 675635003582 ATP binding site [chemical binding]; other site 675635003583 Q-loop/lid; other site 675635003584 ABC transporter signature motif; other site 675635003585 Walker B; other site 675635003586 D-loop; other site 675635003587 H-loop/switch region; other site 675635003588 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 675635003589 Histidine kinase; Region: HisKA_3; pfam07730 675635003590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635003591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635003592 DNA-binding site [nucleotide binding]; DNA binding site 675635003593 FCD domain; Region: FCD; cl11656 675635003594 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635003595 classical (c) SDRs; Region: SDR_c; cd05233 675635003596 NAD(P) binding site [chemical binding]; other site 675635003597 active site 675635003598 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 675635003599 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635003600 carboxyltransferase (CT) interaction site; other site 675635003601 biotinylation site [posttranslational modification]; other site 675635003602 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 675635003603 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635003604 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635003605 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 675635003606 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 675635003607 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 675635003608 active site 675635003609 catalytic residues [active] 675635003610 metal binding site [ion binding]; metal-binding site 675635003611 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 675635003612 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635003613 AMP-binding enzyme; Region: AMP-binding; cl15778 675635003614 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635003615 pyruvate phosphate dikinase; Provisional; Region: PRK05878 675635003616 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 675635003617 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 675635003618 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635003619 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 675635003620 dimer interface [polypeptide binding]; other site 675635003621 active site 675635003622 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 675635003623 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635003624 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635003625 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 675635003626 active site 675635003627 FMN binding site [chemical binding]; other site 675635003628 2,4-decadienoyl-CoA binding site; other site 675635003629 catalytic residue [active] 675635003630 4Fe-4S cluster binding site [ion binding]; other site 675635003631 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 675635003632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635003633 Helix-turn-helix domains; Region: HTH; cl00088 675635003634 CCC1-related family of proteins; Region: CCC1_like; cl00278 675635003635 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635003636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635003637 active site 675635003638 phosphorylation site [posttranslational modification] 675635003639 intermolecular recognition site; other site 675635003640 dimerization interface [polypeptide binding]; other site 675635003641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635003642 DNA binding residues [nucleotide binding] 675635003643 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635003644 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635003645 competence damage-inducible protein A; Provisional; Region: PRK00549 675635003646 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 675635003647 Competence-damaged protein; Region: CinA; cl00666 675635003648 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635003649 Helix-turn-helix domains; Region: HTH; cl00088 675635003650 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635003651 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 675635003652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003653 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 675635003654 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 675635003655 heterodimer interface [polypeptide binding]; other site 675635003656 multimer interface [polypeptide binding]; other site 675635003657 active site 675635003658 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 675635003659 heterodimer interface [polypeptide binding]; other site 675635003660 active site 675635003661 GtrA-like protein; Region: GtrA; cl00971 675635003662 Helix-turn-helix domains; Region: HTH; cl00088 675635003663 short chain dehydrogenase; Provisional; Region: PRK06197 675635003664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003665 NAD(P) binding site [chemical binding]; other site 675635003666 active site 675635003667 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 675635003668 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 675635003669 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 675635003670 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635003671 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 675635003672 putative dimer interface [polypeptide binding]; other site 675635003673 N-terminal domain interface [polypeptide binding]; other site 675635003674 putative substrate binding pocket (H-site) [chemical binding]; other site 675635003675 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 675635003676 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 675635003677 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635003678 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635003679 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 675635003680 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635003681 carboxyltransferase (CT) interaction site; other site 675635003682 biotinylation site [posttranslational modification]; other site 675635003683 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 675635003684 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 675635003685 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635003686 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635003687 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635003688 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635003689 active site 675635003690 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635003691 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635003692 active site 675635003693 metal binding site [ion binding]; metal-binding site 675635003694 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635003695 Helix-turn-helix domains; Region: HTH; cl00088 675635003696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635003697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635003698 putative substrate translocation pore; other site 675635003699 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635003700 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 675635003701 active site 675635003702 ADP/pyrophosphate binding site [chemical binding]; other site 675635003703 dimerization interface [polypeptide binding]; other site 675635003704 allosteric effector site; other site 675635003705 fructose-1,6-bisphosphate binding site; other site 675635003706 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635003707 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635003708 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 675635003709 Membrane protein of unknown function; Region: DUF360; cl00850 675635003710 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 675635003711 AMP-binding enzyme; Region: AMP-binding; cl15778 675635003712 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635003713 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635003714 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635003715 E3 Ubiquitin ligase; Region: GIDE; pfam12483 675635003716 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635003717 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635003718 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635003719 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 675635003720 protein binding site [polypeptide binding]; other site 675635003721 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635003722 Predicted membrane protein [Function unknown]; Region: COG2119 675635003723 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 675635003724 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 675635003725 acyl-CoA synthetase; Validated; Region: PRK08316 675635003726 AMP-binding enzyme; Region: AMP-binding; cl15778 675635003727 AMP-binding enzyme; Region: AMP-binding; cl15778 675635003728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635003729 Helix-turn-helix domains; Region: HTH; cl00088 675635003730 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635003731 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635003732 active site 675635003733 acyl-CoA synthetase; Validated; Region: PRK08316 675635003734 AMP-binding enzyme; Region: AMP-binding; cl15778 675635003735 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635003736 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 675635003737 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 675635003738 putative active site [active] 675635003739 putative substrate binding site [chemical binding]; other site 675635003740 ATP binding site [chemical binding]; other site 675635003741 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 675635003742 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 675635003743 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 675635003744 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635003745 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635003746 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 675635003747 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635003748 carboxyltransferase (CT) interaction site; other site 675635003749 biotinylation site [posttranslational modification]; other site 675635003750 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635003751 AMP-binding enzyme; Region: AMP-binding; cl15778 675635003752 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635003753 enoyl-CoA hydratase; Provisional; Region: PRK06688 675635003754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635003755 substrate binding site [chemical binding]; other site 675635003756 oxyanion hole (OAH) forming residues; other site 675635003757 trimer interface [polypeptide binding]; other site 675635003758 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635003759 AMP-binding enzyme; Region: AMP-binding; cl15778 675635003760 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635003761 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635003762 enoyl-CoA hydratase; Validated; Region: PRK08139 675635003763 substrate binding site [chemical binding]; other site 675635003764 oxyanion hole (OAH) forming residues; other site 675635003765 trimer interface [polypeptide binding]; other site 675635003766 TIGR03084 family protein; Region: TIGR03084 675635003767 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635003768 Wyosine base formation; Region: Wyosine_form; pfam08608 675635003769 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 675635003770 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635003771 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635003772 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635003773 flavoprotein, HI0933 family; Region: TIGR00275 675635003774 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 675635003775 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635003776 AIR carboxylase; Region: AIRC; cl00310 675635003777 Protein of unknown function DUF111; Region: DUF111; cl03398 675635003778 OsmC-like protein; Region: OsmC; cl00767 675635003779 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 675635003780 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 675635003781 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 675635003782 tetramer interface [polypeptide binding]; other site 675635003783 active site 675635003784 D-cysteine desulfhydrase; Validated; Region: PRK03910 675635003785 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 675635003786 catalytic residue [active] 675635003787 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 675635003788 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 675635003789 tetramer interface [polypeptide binding]; other site 675635003790 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 675635003791 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635003792 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635003793 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 675635003794 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635003795 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 675635003796 Helix-turn-helix domains; Region: HTH; cl00088 675635003797 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635003798 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635003799 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 675635003800 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 675635003801 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 675635003802 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 675635003803 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635003804 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635003805 Helix-turn-helix domains; Region: HTH; cl00088 675635003806 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635003807 Helix-turn-helix domains; Region: HTH; cl00088 675635003808 DNA binding site [nucleotide binding] 675635003809 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635003810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 675635003811 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635003812 DNA binding residues [nucleotide binding] 675635003813 dimerization interface [polypeptide binding]; other site 675635003814 Cupin domain; Region: Cupin_2; cl09118 675635003815 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 675635003816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003817 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 675635003818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 675635003819 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 675635003820 putative inner membrane protein; Provisional; Region: PRK11099 675635003821 Sulphur transport; Region: Sulf_transp; cl01018 675635003822 putative inner membrane protein; Provisional; Region: PRK11099 675635003823 Sulphur transport; Region: Sulf_transp; cl01018 675635003824 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 675635003825 active site 675635003826 ADP/pyrophosphate binding site [chemical binding]; other site 675635003827 dimerization interface [polypeptide binding]; other site 675635003828 allosteric effector site; other site 675635003829 fructose-1,6-bisphosphate binding site; other site 675635003830 Clp protease; Region: CLP_protease; pfam00574 675635003831 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 675635003832 oligomer interface [polypeptide binding]; other site 675635003833 active site residues [active] 675635003834 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 675635003835 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635003836 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635003837 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635003838 Repair protein; Region: Repair_PSII; cl01535 675635003839 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 675635003840 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 675635003841 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 675635003842 putative [4Fe-4S] binding site [ion binding]; other site 675635003843 putative molybdopterin cofactor binding site [chemical binding]; other site 675635003844 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 675635003845 putative molybdopterin cofactor binding site; other site 675635003846 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 675635003847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635003848 Domain of unknown function (DUF305); Region: DUF305; cl15795 675635003849 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 675635003850 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 675635003851 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 675635003852 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 675635003853 active site 675635003854 HIGH motif; other site 675635003855 KMSK motif region; other site 675635003856 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 675635003857 tRNA binding surface [nucleotide binding]; other site 675635003858 anticodon binding site; other site 675635003859 diaminopimelate decarboxylase; Region: lysA; TIGR01048 675635003860 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 675635003861 active site 675635003862 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 675635003863 substrate binding site [chemical binding]; other site 675635003864 catalytic residues [active] 675635003865 dimer interface [polypeptide binding]; other site 675635003866 homoserine dehydrogenase; Provisional; Region: PRK06349 675635003867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003868 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 675635003869 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 675635003870 threonine synthase; Reviewed; Region: PRK06721 675635003871 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 675635003872 homodimer interface [polypeptide binding]; other site 675635003873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635003874 catalytic residue [active] 675635003875 homoserine kinase; Provisional; Region: PRK01212 675635003876 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 675635003877 transcription termination factor Rho; Provisional; Region: PRK12608 675635003878 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 675635003879 RNA binding site [nucleotide binding]; other site 675635003880 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 675635003881 multimer interface [polypeptide binding]; other site 675635003882 Walker A motif; other site 675635003883 ATP binding site [chemical binding]; other site 675635003884 Walker B motif; other site 675635003885 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 675635003886 peptide chain release factor 1; Validated; Region: prfA; PRK00591 675635003887 RF-1 domain; Region: RF-1; cl02875 675635003888 RF-1 domain; Region: RF-1; cl02875 675635003889 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 675635003890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003891 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 675635003892 Helix-turn-helix domains; Region: HTH; cl00088 675635003893 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 675635003894 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 675635003895 dimer interface [polypeptide binding]; other site 675635003896 active site 675635003897 glycine-pyridoxal phosphate binding site [chemical binding]; other site 675635003898 folate binding site [chemical binding]; other site 675635003899 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 675635003900 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 675635003901 Mg++ binding site [ion binding]; other site 675635003902 putative catalytic motif [active] 675635003903 substrate binding site [chemical binding]; other site 675635003904 ATP synthase A chain; Region: ATP-synt_A; cl00413 675635003905 ATP synthase subunit C; Region: ATP-synt_C; cl00466 675635003906 Plant ATP synthase F0; Region: YMF19; cl07975 675635003907 Plant ATP synthase F0; Region: YMF19; cl07975 675635003908 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 675635003909 Plant ATP synthase F0; Region: YMF19; cl07975 675635003910 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 675635003911 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 675635003912 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 675635003913 beta subunit interaction interface [polypeptide binding]; other site 675635003914 Walker A motif; other site 675635003915 ATP binding site [chemical binding]; other site 675635003916 Walker B motif; other site 675635003917 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 675635003918 ATP synthase; Region: ATP-synt; cl00365 675635003919 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 675635003920 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 675635003921 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 675635003922 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 675635003923 alpha subunit interaction interface [polypeptide binding]; other site 675635003924 Walker A motif; other site 675635003925 ATP binding site [chemical binding]; other site 675635003926 Walker B motif; other site 675635003927 inhibitor binding site; inhibition site 675635003928 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 675635003929 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 675635003930 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 675635003931 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 675635003932 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 675635003933 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 675635003934 hinge; other site 675635003935 active site 675635003936 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 675635003937 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 675635003938 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 675635003939 B12 binding site [chemical binding]; other site 675635003940 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 675635003941 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 675635003942 substrate binding pocket [chemical binding]; other site 675635003943 membrane-bound complex binding site; other site 675635003944 hinge residues; other site 675635003945 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 675635003946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635003947 dimer interface [polypeptide binding]; other site 675635003948 conserved gate region; other site 675635003949 putative PBP binding loops; other site 675635003950 ABC-ATPase subunit interface; other site 675635003951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635003952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635003953 ABC-ATPase subunit interface; other site 675635003954 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 675635003955 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635003956 Walker A/P-loop; other site 675635003957 ATP binding site [chemical binding]; other site 675635003958 Q-loop/lid; other site 675635003959 ABC transporter signature motif; other site 675635003960 Walker B; other site 675635003961 D-loop; other site 675635003962 H-loop/switch region; other site 675635003963 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 675635003964 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 675635003965 substrate binding pocket [chemical binding]; other site 675635003966 membrane-bound complex binding site; other site 675635003967 enoyl-CoA hydratase; Validated; Region: PRK08139 675635003968 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635003969 substrate binding site [chemical binding]; other site 675635003970 oxyanion hole (OAH) forming residues; other site 675635003971 trimer interface [polypeptide binding]; other site 675635003972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635003973 Helix-turn-helix domains; Region: HTH; cl00088 675635003974 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635003975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003976 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635003977 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635003978 active site 675635003979 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 675635003980 dimer interface [polypeptide binding]; other site 675635003981 ADP-ribose binding site [chemical binding]; other site 675635003982 active site 675635003983 nudix motif; other site 675635003984 metal binding site [ion binding]; metal-binding site 675635003985 Helix-turn-helix domains; Region: HTH; cl00088 675635003986 WYL domain; Region: WYL; cl14852 675635003987 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635003988 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635003989 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635003990 active site 675635003991 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635003992 Predicted ATPase [General function prediction only]; Region: COG3899 675635003993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635003994 DNA binding residues [nucleotide binding] 675635003995 dimerization interface [polypeptide binding]; other site 675635003996 Protein of unknown function DUF91; Region: DUF91; cl00709 675635003997 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635003998 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 675635003999 tetramer interface [polypeptide binding]; other site 675635004000 catalytic Zn binding site [ion binding]; other site 675635004001 NADP binding site [chemical binding]; other site 675635004002 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635004003 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 675635004004 NAD(P) binding site [chemical binding]; other site 675635004005 catalytic residues [active] 675635004006 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 675635004007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004008 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 675635004009 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 675635004010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004011 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 675635004012 cell division protein GpsB; Provisional; Region: PRK14127 675635004013 DivIVA domain; Region: DivI1A_domain; TIGR03544 675635004014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004015 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 675635004016 NAD(P) binding site [chemical binding]; other site 675635004017 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 675635004018 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635004019 dimer interface [polypeptide binding]; other site 675635004020 substrate binding site [chemical binding]; other site 675635004021 metal binding site [ion binding]; metal-binding site 675635004022 putative acyltransferase; Provisional; Region: PRK05790 675635004023 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635004024 dimer interface [polypeptide binding]; other site 675635004025 active site 675635004026 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 675635004027 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 675635004028 Walker A; other site 675635004029 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635004030 G5 box; other site 675635004031 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635004032 Helix-turn-helix domains; Region: HTH; cl00088 675635004033 Helix-turn-helix domains; Region: HTH; cl00088 675635004034 Domain of unknown function DUF77; Region: DUF77; cl00307 675635004035 Winged helix-turn helix; Region: HTH_29; pfam13551 675635004036 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635004037 Helix-turn-helix domains; Region: HTH; cl00088 675635004038 Integrase core domain; Region: rve; cl01316 675635004039 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 675635004040 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 675635004041 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 675635004042 glycogen branching enzyme; Provisional; Region: PRK05402 675635004043 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 675635004044 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 675635004045 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 675635004046 active site 675635004047 catalytic site [active] 675635004048 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 675635004049 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 675635004050 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635004051 MgtE intracellular N domain; Region: MgtE_N; cl15244 675635004052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635004053 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 675635004054 trehalose synthase; Region: treS_nterm; TIGR02456 675635004055 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 675635004056 active site 675635004057 catalytic site [active] 675635004058 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 675635004059 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 675635004060 active site 675635004061 homodimer interface [polypeptide binding]; other site 675635004062 catalytic site [active] 675635004063 acceptor binding site [chemical binding]; other site 675635004064 glycogen branching enzyme; Provisional; Region: PRK12313 675635004065 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 675635004066 putative homodimer interface [polypeptide binding]; other site 675635004067 putative active site pocket [active] 675635004068 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 675635004069 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 675635004070 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 675635004071 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 675635004072 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 675635004073 active site 675635004074 catalytic site [active] 675635004075 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 675635004076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635004077 Walker A/P-loop; other site 675635004078 ATP binding site [chemical binding]; other site 675635004079 Q-loop/lid; other site 675635004080 ABC transporter signature motif; other site 675635004081 Walker B; other site 675635004082 D-loop; other site 675635004083 H-loop/switch region; other site 675635004084 enoyl-CoA hydratase; Provisional; Region: PRK05862 675635004085 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635004086 substrate binding site [chemical binding]; other site 675635004087 oxyanion hole (OAH) forming residues; other site 675635004088 trimer interface [polypeptide binding]; other site 675635004089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635004090 S-adenosylmethionine binding site [chemical binding]; other site 675635004091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635004092 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635004093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635004094 active site 675635004095 phosphorylation site [posttranslational modification] 675635004096 intermolecular recognition site; other site 675635004097 dimerization interface [polypeptide binding]; other site 675635004098 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635004099 DNA binding residues [nucleotide binding] 675635004100 dimerization interface [polypeptide binding]; other site 675635004101 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635004102 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635004103 DNA binding residues [nucleotide binding] 675635004104 dimerization interface [polypeptide binding]; other site 675635004105 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 675635004106 trimer interface [polypeptide binding]; other site 675635004107 active site 675635004108 substrate binding site [chemical binding]; other site 675635004109 CoA binding site [chemical binding]; other site 675635004110 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635004111 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 675635004112 Helix-turn-helix domains; Region: HTH; cl00088 675635004113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635004114 dimerization interface [polypeptide binding]; other site 675635004115 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635004116 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635004117 active site 675635004118 non-prolyl cis peptide bond; other site 675635004119 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 675635004120 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635004121 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635004122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635004123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635004124 dimer interface [polypeptide binding]; other site 675635004125 conserved gate region; other site 675635004126 putative PBP binding loops; other site 675635004127 ABC-ATPase subunit interface; other site 675635004128 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635004129 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 675635004130 Walker A/P-loop; other site 675635004131 ATP binding site [chemical binding]; other site 675635004132 Q-loop/lid; other site 675635004133 ABC transporter signature motif; other site 675635004134 Walker B; other site 675635004135 D-loop; other site 675635004136 H-loop/switch region; other site 675635004137 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635004138 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 675635004139 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635004140 Walker A/P-loop; other site 675635004141 ATP binding site [chemical binding]; other site 675635004142 Q-loop/lid; other site 675635004143 ABC transporter signature motif; other site 675635004144 Walker B; other site 675635004145 D-loop; other site 675635004146 H-loop/switch region; other site 675635004147 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635004148 Cupin domain; Region: Cupin_2; cl09118 675635004149 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 675635004150 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635004151 Uncharacterized conserved protein [Function unknown]; Region: COG1543 675635004152 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 675635004153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004154 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 675635004155 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635004156 allantoicase; Provisional; Region: PRK13257 675635004157 Allantoicase repeat; Region: Allantoicase; pfam03561 675635004158 Allantoicase repeat; Region: Allantoicase; pfam03561 675635004159 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 675635004160 allantoinase; Region: allantoinase; TIGR03178 675635004161 active site 675635004162 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 675635004163 putative active site pocket [active] 675635004164 allophanate hydrolase; Region: allophanate_hyd; TIGR02713 675635004165 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 675635004166 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635004167 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635004168 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 675635004169 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 675635004170 active site 675635004171 putative substrate binding pocket [chemical binding]; other site 675635004172 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635004173 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635004174 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635004175 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 675635004176 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635004177 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 675635004178 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 675635004179 Helix-turn-helix domains; Region: HTH; cl00088 675635004180 urate oxidase; Region: urate_oxi; TIGR03383 675635004181 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 675635004182 active site 675635004183 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 675635004184 active site 675635004185 homotetramer interface [polypeptide binding]; other site 675635004186 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 675635004187 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 675635004188 xanthine permease; Region: pbuX; TIGR03173 675635004189 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 675635004190 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 675635004191 Ligand binding site [chemical binding]; other site 675635004192 Electron transfer flavoprotein domain; Region: ETF; pfam01012 675635004193 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 675635004194 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 675635004195 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 675635004196 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635004197 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 675635004198 putative acyl-acceptor binding pocket; other site 675635004199 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635004200 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 675635004201 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635004202 catalytic residue [active] 675635004203 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 675635004204 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 675635004205 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 675635004206 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635004207 AMP-binding enzyme; Region: AMP-binding; cl15778 675635004208 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635004209 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 675635004210 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635004211 active site 675635004212 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635004213 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635004214 active site 675635004215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635004216 Helix-turn-helix domains; Region: HTH; cl00088 675635004217 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 675635004218 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 675635004219 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635004220 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635004221 catalytic residue [active] 675635004222 Clp amino terminal domain; Region: Clp_N; pfam02861 675635004223 Clp amino terminal domain; Region: Clp_N; pfam02861 675635004224 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 675635004225 Ligase N family; Region: LIGANc; smart00532 675635004226 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 675635004227 nucleotide binding pocket [chemical binding]; other site 675635004228 K-X-D-G motif; other site 675635004229 catalytic site [active] 675635004230 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 675635004231 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 675635004232 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 675635004233 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 675635004234 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 675635004235 Dimer interface [polypeptide binding]; other site 675635004236 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 675635004237 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 675635004238 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 675635004239 FAD binding pocket [chemical binding]; other site 675635004240 FAD binding motif [chemical binding]; other site 675635004241 phosphate binding motif [ion binding]; other site 675635004242 beta-alpha-beta structure motif; other site 675635004243 NAD binding pocket [chemical binding]; other site 675635004244 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635004245 catalytic loop [active] 675635004246 iron binding site [ion binding]; other site 675635004247 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 675635004248 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 675635004249 putative di-iron ligands [ion binding]; other site 675635004250 Helix-turn-helix domains; Region: HTH; cl00088 675635004251 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 675635004252 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 675635004253 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635004254 Amidase; Region: Amidase; cl11426 675635004255 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 675635004256 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 675635004257 GatB domain; Region: GatB_Yqey; cl11497 675635004258 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 675635004259 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635004260 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 675635004261 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 675635004262 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635004263 NAD binding site [chemical binding]; other site 675635004264 catalytic residues [active] 675635004265 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635004266 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635004267 Transcriptional regulators [Transcription]; Region: PurR; COG1609 675635004268 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 675635004269 DNA binding site [nucleotide binding] 675635004270 domain linker motif; other site 675635004271 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 675635004272 dimerization interface [polypeptide binding]; other site 675635004273 ligand binding site [chemical binding]; other site 675635004274 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635004275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635004276 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635004277 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635004278 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635004279 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635004280 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635004281 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635004282 active site 675635004283 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635004284 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635004285 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635004286 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 675635004287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004288 NAD(P) binding site [chemical binding]; other site 675635004289 active site 675635004290 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 675635004291 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 675635004292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004293 DoxX; Region: DoxX; cl00976 675635004294 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 675635004295 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 675635004296 Dehydratase family; Region: ILVD_EDD; cl00340 675635004297 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 675635004298 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 675635004299 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635004300 PYR/PP interface [polypeptide binding]; other site 675635004301 dimer interface [polypeptide binding]; other site 675635004302 TPP binding site [chemical binding]; other site 675635004303 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 675635004304 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 675635004305 TPP-binding site [chemical binding]; other site 675635004306 dimer interface [polypeptide binding]; other site 675635004307 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 675635004308 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 675635004309 putative valine binding site [chemical binding]; other site 675635004310 dimer interface [polypeptide binding]; other site 675635004311 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 675635004312 ketol-acid reductoisomerase; Provisional; Region: PRK05479 675635004313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004314 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 675635004315 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635004316 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635004317 hypothetical protein; Provisional; Region: PRK08317 675635004318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635004319 S-adenosylmethionine binding site [chemical binding]; other site 675635004320 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 675635004321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004322 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 675635004323 putative L-serine binding site [chemical binding]; other site 675635004324 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 675635004325 tartrate dehydrogenase; Provisional; Region: PRK08194 675635004326 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 675635004327 hypothetical protein; Provisional; Region: PRK06185 675635004328 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 675635004329 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 675635004330 HIGH motif; other site 675635004331 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 675635004332 active site 675635004333 KMSKS motif; other site 675635004334 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 675635004335 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635004336 Helix-turn-helix domains; Region: HTH; cl00088 675635004337 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635004338 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 675635004339 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 675635004340 substrate binding site [chemical binding]; other site 675635004341 ligand binding site [chemical binding]; other site 675635004342 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 675635004343 substrate binding site [chemical binding]; other site 675635004344 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 675635004345 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 675635004346 active site 675635004347 Ap6A binding site [chemical binding]; other site 675635004348 nudix motif; other site 675635004349 metal binding site [ion binding]; metal-binding site 675635004350 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635004351 catalytic core [active] 675635004352 polyphosphate kinase; Provisional; Region: PRK05443 675635004353 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 675635004354 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 675635004355 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 675635004356 putative domain interface [polypeptide binding]; other site 675635004357 putative active site [active] 675635004358 catalytic site [active] 675635004359 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 675635004360 putative domain interface [polypeptide binding]; other site 675635004361 putative active site [active] 675635004362 catalytic site [active] 675635004363 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635004364 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 675635004365 putative acyl-acceptor binding pocket; other site 675635004366 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 675635004367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004368 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 675635004369 cystathionine gamma-lyase; Validated; Region: PRK07582 675635004370 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635004371 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635004372 catalytic residue [active] 675635004373 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 675635004374 active site 675635004375 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 675635004376 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 675635004377 Bacterial sugar transferase; Region: Bac_transf; cl00939 675635004378 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 675635004379 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635004380 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635004381 catalytic residue [active] 675635004382 Chain length determinant protein; Region: Wzz; cl15801 675635004383 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 675635004384 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 675635004385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004386 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 675635004387 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 675635004388 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 675635004389 active site 675635004390 dimer interface [polypeptide binding]; other site 675635004391 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 675635004392 Ligand Binding Site [chemical binding]; other site 675635004393 Molecular Tunnel; other site 675635004394 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635004395 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 675635004396 putative NAD(P) binding site [chemical binding]; other site 675635004397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004398 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 675635004399 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 675635004400 Right handed beta helix region; Region: Beta_helix; pfam13229 675635004401 O-Antigen ligase; Region: Wzy_C; cl04850 675635004402 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635004403 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635004404 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635004405 putative trimer interface [polypeptide binding]; other site 675635004406 putative CoA binding site [chemical binding]; other site 675635004407 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 675635004408 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 675635004409 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 675635004410 active site 675635004411 MatE; Region: MatE; cl10513 675635004412 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 675635004413 active site 675635004414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635004415 active site 675635004416 Repair protein; Region: Repair_PSII; cl01535 675635004417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635004418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635004419 ATP binding site [chemical binding]; other site 675635004420 Mg2+ binding site [ion binding]; other site 675635004421 G-X-G motif; other site 675635004422 Transposase domain (DUF772); Region: DUF772; cl15789 675635004423 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635004424 Transposase domain (DUF772); Region: DUF772; cl15789 675635004425 Right handed beta helix region; Region: Beta_helix; pfam13229 675635004426 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 675635004427 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635004428 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635004429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635004430 active site 675635004431 phosphorylation site [posttranslational modification] 675635004432 intermolecular recognition site; other site 675635004433 dimerization interface [polypeptide binding]; other site 675635004434 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635004435 DNA binding site [nucleotide binding] 675635004436 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 675635004437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635004438 dimer interface [polypeptide binding]; other site 675635004439 phosphorylation site [posttranslational modification] 675635004440 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635004441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635004442 ATP binding site [chemical binding]; other site 675635004443 Mg2+ binding site [ion binding]; other site 675635004444 G-X-G motif; other site 675635004445 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 675635004446 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635004447 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 675635004448 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 675635004449 putative active site [active] 675635004450 putative metal binding site [ion binding]; other site 675635004451 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 675635004452 putative active site [active] 675635004453 putative metal binding site [ion binding]; other site 675635004454 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635004455 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635004456 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 675635004457 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635004458 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 675635004459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004460 NAD(P) binding site [chemical binding]; other site 675635004461 active site 675635004462 O-Antigen ligase; Region: Wzy_C; cl04850 675635004463 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635004464 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635004465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004466 Bacterial sugar transferase; Region: Bac_transf; cl00939 675635004467 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 675635004468 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 675635004469 Ligand binding site; other site 675635004470 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635004471 MatE; Region: MatE; cl10513 675635004472 integral membrane protein MviN; Region: mviN; TIGR01695 675635004473 outer membrane N-deacetylase; Provisional; Region: hmsF; PRK14581 675635004474 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 675635004475 putative active site [active] 675635004476 putative metal binding site [ion binding]; other site 675635004477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 675635004478 active site 675635004479 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635004480 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 675635004481 putative trimer interface [polypeptide binding]; other site 675635004482 putative active site [active] 675635004483 putative substrate binding site [chemical binding]; other site 675635004484 putative CoA binding site [chemical binding]; other site 675635004485 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 675635004486 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 675635004487 inhibitor-cofactor binding pocket; inhibition site 675635004488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635004489 catalytic residue [active] 675635004490 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 675635004491 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 675635004492 inhibitor-cofactor binding pocket; inhibition site 675635004493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635004494 catalytic residue [active] 675635004495 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635004496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004498 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 675635004499 NAD(P) binding site [chemical binding]; other site 675635004500 active site 675635004501 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 675635004502 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 675635004503 Zn binding site [ion binding]; other site 675635004504 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 675635004505 Cupin domain; Region: Cupin_2; cl09118 675635004506 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635004507 extended (e) SDRs; Region: SDR_e; cd08946 675635004508 NAD(P) binding site [chemical binding]; other site 675635004509 active site 675635004510 substrate binding site [chemical binding]; other site 675635004511 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635004512 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 675635004513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004514 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 675635004515 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 675635004516 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635004517 FOG: CBS domain [General function prediction only]; Region: COG0517 675635004518 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 675635004519 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 675635004520 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635004521 NAD binding site [chemical binding]; other site 675635004522 catalytic residues [active] 675635004523 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635004524 active site 675635004525 ATP binding site [chemical binding]; other site 675635004526 substrate binding site [chemical binding]; other site 675635004527 activation loop (A-loop); other site 675635004528 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 675635004529 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 675635004530 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635004531 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 675635004532 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 675635004533 active site 675635004534 dimer interface [polypeptide binding]; other site 675635004535 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 675635004536 Ligand Binding Site [chemical binding]; other site 675635004537 Molecular Tunnel; other site 675635004538 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 675635004539 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 675635004540 Uncharacterized conserved protein [Function unknown]; Region: COG2308 675635004541 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 675635004542 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 675635004543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635004544 motif II; other site 675635004545 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635004546 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 675635004547 Protein of unknown function (DUF429); Region: DUF429; cl12046 675635004548 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 675635004549 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 675635004550 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 675635004551 putative DNA binding site [nucleotide binding]; other site 675635004552 catalytic residue [active] 675635004553 putative H2TH interface [polypeptide binding]; other site 675635004554 putative catalytic residues [active] 675635004555 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 675635004556 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 675635004557 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 675635004558 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 675635004559 RNA polymerase factor sigma-70; Validated; Region: PRK08241 675635004560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635004561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635004562 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635004563 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635004564 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 675635004565 intersubunit interface [polypeptide binding]; other site 675635004566 active site 675635004567 Zn2+ binding site [ion binding]; other site 675635004568 Cupin domain; Region: Cupin_2; cl09118 675635004569 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 675635004570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635004571 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 675635004572 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 675635004573 active site 675635004574 HIGH motif; other site 675635004575 dimer interface [polypeptide binding]; other site 675635004576 KMSKS motif; other site 675635004577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635004578 Helix-turn-helix domains; Region: HTH; cl00088 675635004579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635004580 dimerization interface [polypeptide binding]; other site 675635004581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 675635004582 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 675635004583 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635004584 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 675635004585 Helix-turn-helix domains; Region: HTH; cl00088 675635004586 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 675635004587 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 675635004588 Walker A/P-loop; other site 675635004589 ATP binding site [chemical binding]; other site 675635004590 Q-loop/lid; other site 675635004591 ABC transporter signature motif; other site 675635004592 Walker B; other site 675635004593 D-loop; other site 675635004594 H-loop/switch region; other site 675635004595 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 675635004596 FtsX-like permease family; Region: FtsX; cl15850 675635004597 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635004598 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635004599 putative NAD(P) binding site [chemical binding]; other site 675635004600 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 675635004601 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 675635004602 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 675635004603 conserved cys residue [active] 675635004604 Uncharacterized conserved protein [Function unknown]; Region: COG4850 675635004605 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 675635004606 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 675635004607 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 675635004608 homodimer interface [polypeptide binding]; other site 675635004609 active site 675635004610 TDP-binding site; other site 675635004611 acceptor substrate-binding pocket; other site 675635004612 LysE type translocator; Region: LysE; cl00565 675635004613 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 675635004614 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635004615 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635004616 Domain of unknown function (DUF385); Region: DUF385; cl04387 675635004617 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 675635004618 Cation efflux family; Region: Cation_efflux; cl00316 675635004619 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 675635004620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004621 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 675635004622 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 675635004623 active site 675635004624 dimer interface [polypeptide binding]; other site 675635004625 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 675635004626 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 675635004627 active site 675635004628 FMN binding site [chemical binding]; other site 675635004629 substrate binding site [chemical binding]; other site 675635004630 3Fe-4S cluster binding site [ion binding]; other site 675635004631 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 675635004632 domain interface; other site 675635004633 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 675635004634 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 675635004635 Asp23 family; Region: Asp23; cl00574 675635004636 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 675635004637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635004638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635004639 DNA binding residues [nucleotide binding] 675635004640 CsbD-like; Region: CsbD; cl15799 675635004641 trigger factor; Provisional; Region: tig; PRK01490 675635004642 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 675635004643 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 675635004644 Clp protease; Region: CLP_protease; pfam00574 675635004645 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 675635004646 oligomer interface [polypeptide binding]; other site 675635004647 active site residues [active] 675635004648 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 675635004649 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 675635004650 oligomer interface [polypeptide binding]; other site 675635004651 active site residues [active] 675635004652 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 675635004653 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 675635004654 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635004655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635004656 Walker A motif; other site 675635004657 ATP binding site [chemical binding]; other site 675635004658 Walker B motif; other site 675635004659 arginine finger; other site 675635004660 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 675635004661 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635004662 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635004663 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 675635004664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635004665 putative substrate translocation pore; other site 675635004666 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635004667 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 675635004668 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635004669 active site 675635004670 HIGH motif; other site 675635004671 nucleotide binding site [chemical binding]; other site 675635004672 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 675635004673 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 675635004674 active site 675635004675 KMSKS motif; other site 675635004676 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 675635004677 tRNA binding surface [nucleotide binding]; other site 675635004678 anticodon binding site; other site 675635004679 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 675635004680 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 675635004681 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 675635004682 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 675635004683 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 675635004684 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 675635004685 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 675635004686 active site 675635004687 multimer interface [polypeptide binding]; other site 675635004688 nodulation ABC transporter NodI; Provisional; Region: PRK13537 675635004689 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635004690 Walker A/P-loop; other site 675635004691 ATP binding site [chemical binding]; other site 675635004692 Q-loop/lid; other site 675635004693 ABC transporter signature motif; other site 675635004694 Walker B; other site 675635004695 D-loop; other site 675635004696 H-loop/switch region; other site 675635004697 ABC-2 type transporter; Region: ABC2_membrane; cl11417 675635004698 ABC-2 type transporter; Region: ABC2_membrane; cl11417 675635004699 Cupin domain; Region: Cupin_2; cl09118 675635004700 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 675635004701 dihydrodipicolinate synthase; Region: dapA; TIGR00674 675635004702 dimer interface [polypeptide binding]; other site 675635004703 active site 675635004704 catalytic residue [active] 675635004705 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 675635004706 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635004707 FeS/SAM binding site; other site 675635004708 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 675635004709 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635004710 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 675635004711 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 675635004712 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 675635004713 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 675635004714 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 675635004715 homodimer interface [polypeptide binding]; other site 675635004716 oligonucleotide binding site [chemical binding]; other site 675635004717 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 675635004718 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 675635004719 GTPase CgtA; Reviewed; Region: obgE; PRK12296 675635004720 GTP1/OBG; Region: GTP1_OBG; pfam01018 675635004721 Obg GTPase; Region: Obg; cd01898 675635004722 G1 box; other site 675635004723 GTP/Mg2+ binding site [chemical binding]; other site 675635004724 Switch I region; other site 675635004725 G2 box; other site 675635004726 G3 box; other site 675635004727 Switch II region; other site 675635004728 G4 box; other site 675635004729 G5 box; other site 675635004730 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 675635004731 gamma-glutamyl kinase; Provisional; Region: PRK05429 675635004732 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 675635004733 nucleotide binding site [chemical binding]; other site 675635004734 homotetrameric interface [polypeptide binding]; other site 675635004735 putative phosphate binding site [ion binding]; other site 675635004736 putative allosteric binding site; other site 675635004737 PUA domain; Region: PUA; cl00607 675635004738 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 675635004739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635004741 ATP binding site [chemical binding]; other site 675635004742 putative Mg++ binding site [ion binding]; other site 675635004743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635004744 nucleotide binding region [chemical binding]; other site 675635004745 ATP-binding site [chemical binding]; other site 675635004746 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 675635004747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635004748 Walker A motif; other site 675635004749 ATP binding site [chemical binding]; other site 675635004750 Walker B motif; other site 675635004751 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 675635004752 arginine finger; other site 675635004753 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 675635004754 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 675635004755 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635004756 putative Zn2+ binding site [ion binding]; other site 675635004757 putative DNA binding site [nucleotide binding]; other site 675635004758 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635004759 Helix-turn-helix domains; Region: HTH; cl00088 675635004760 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 675635004761 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635004762 Predicted ATPase [General function prediction only]; Region: COG3899 675635004763 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 675635004764 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 675635004765 Helix-turn-helix domains; Region: HTH; cl00088 675635004766 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 675635004767 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 675635004768 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 675635004769 active site 675635004770 (T/H)XGH motif; other site 675635004771 Oligomerisation domain; Region: Oligomerisation; cl00519 675635004772 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635004773 catalytic core [active] 675635004774 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 675635004775 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 675635004776 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 675635004777 threonine synthase; Validated; Region: PRK07591 675635004778 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 675635004779 homodimer interface [polypeptide binding]; other site 675635004780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635004781 catalytic residue [active] 675635004782 hypothetical protein; Reviewed; Region: PRK07914 675635004783 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 675635004784 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 675635004785 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635004786 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635004787 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 675635004788 NHL repeat; Region: NHL; pfam01436 675635004789 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 675635004790 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635004791 Walker A/P-loop; other site 675635004792 ATP binding site [chemical binding]; other site 675635004793 Q-loop/lid; other site 675635004794 ABC transporter signature motif; other site 675635004795 Walker B; other site 675635004796 D-loop; other site 675635004797 H-loop/switch region; other site 675635004798 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 675635004799 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 675635004800 DNA binding site [nucleotide binding] 675635004801 catalytic residue [active] 675635004802 H2TH interface [polypeptide binding]; other site 675635004803 putative catalytic residues [active] 675635004804 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 675635004805 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 675635004806 active site 675635004807 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 675635004808 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 675635004809 active site 675635004810 dimer interface [polypeptide binding]; other site 675635004811 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 675635004812 dimer interface [polypeptide binding]; other site 675635004813 active site 675635004814 DoxX; Region: DoxX; cl00976 675635004815 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 675635004816 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 675635004817 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 675635004818 putative active site [active] 675635004819 putative substrate binding site [chemical binding]; other site 675635004820 ATP binding site [chemical binding]; other site 675635004821 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635004822 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635004823 catalytic residue [active] 675635004824 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 675635004825 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 675635004826 NodB motif; other site 675635004827 active site 675635004828 catalytic site [active] 675635004829 metal binding site [ion binding]; metal-binding site 675635004830 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635004831 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 675635004832 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 675635004833 active site 675635004834 metal binding site [ion binding]; metal-binding site 675635004835 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 675635004836 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 675635004837 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 675635004838 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 675635004839 siderophore binding site; other site 675635004840 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 675635004841 Cl- selectivity filter; other site 675635004842 Cl- binding residues [ion binding]; other site 675635004843 pore gating glutamate residue; other site 675635004844 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 675635004845 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635004846 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 675635004847 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 675635004848 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635004849 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635004850 DNA binding residues [nucleotide binding] 675635004851 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635004852 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 675635004853 putative hydrophobic ligand binding site [chemical binding]; other site 675635004854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635004855 dimerization interface [polypeptide binding]; other site 675635004856 putative DNA binding site [nucleotide binding]; other site 675635004857 putative Zn2+ binding site [ion binding]; other site 675635004858 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 675635004859 amphipathic channel; other site 675635004860 Asn-Pro-Ala signature motifs; other site 675635004861 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 675635004862 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635004863 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635004864 catalytic residue [active] 675635004865 Helix-turn-helix domains; Region: HTH; cl00088 675635004866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635004867 putative substrate translocation pore; other site 675635004868 Predicted acyl esterases [General function prediction only]; Region: COG2936 675635004869 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 675635004870 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 675635004871 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 675635004872 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 675635004873 putative DNA binding site [nucleotide binding]; other site 675635004874 putative homodimer interface [polypeptide binding]; other site 675635004875 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 675635004876 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635004877 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635004878 active site 675635004879 non-prolyl cis peptide bond; other site 675635004880 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 675635004881 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635004882 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635004883 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 675635004884 DNA binding site [nucleotide binding] 675635004885 domain linker motif; other site 675635004886 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 675635004887 ligand binding site [chemical binding]; other site 675635004888 dimerization interface [polypeptide binding]; other site 675635004889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635004890 Helix-turn-helix domains; Region: HTH; cl00088 675635004891 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 675635004892 AMP-binding enzyme; Region: AMP-binding; cl15778 675635004893 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635004894 substrate binding site [chemical binding]; other site 675635004895 oxyanion hole (OAH) forming residues; other site 675635004896 trimer interface [polypeptide binding]; other site 675635004897 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635004898 substrate binding site [chemical binding]; other site 675635004899 trimer interface [polypeptide binding]; other site 675635004900 oxyanion hole (OAH) forming residues; other site 675635004901 enoyl-CoA hydratase; Provisional; Region: PRK07799 675635004902 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635004903 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 675635004904 ligand binding site [chemical binding]; other site 675635004905 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635004906 TM-ABC transporter signature motif; other site 675635004907 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635004908 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 675635004909 Walker A/P-loop; other site 675635004910 ATP binding site [chemical binding]; other site 675635004911 Q-loop/lid; other site 675635004912 ABC transporter signature motif; other site 675635004913 Walker B; other site 675635004914 D-loop; other site 675635004915 H-loop/switch region; other site 675635004916 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635004917 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 675635004918 Walker A/P-loop; other site 675635004919 ATP binding site [chemical binding]; other site 675635004920 Q-loop/lid; other site 675635004921 ABC transporter signature motif; other site 675635004922 Walker B; other site 675635004923 D-loop; other site 675635004924 H-loop/switch region; other site 675635004925 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635004926 TM-ABC transporter signature motif; other site 675635004927 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635004928 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635004929 substrate binding site [chemical binding]; other site 675635004930 oxyanion hole (OAH) forming residues; other site 675635004931 trimer interface [polypeptide binding]; other site 675635004932 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 675635004933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004934 NAD(P) binding site [chemical binding]; other site 675635004935 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 675635004936 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 675635004937 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635004938 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635004939 active site 2 [active] 675635004940 active site 1 [active] 675635004941 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635004942 tetramer interface [polypeptide binding]; other site 675635004943 TPP-binding site [chemical binding]; other site 675635004944 heterodimer interface [polypeptide binding]; other site 675635004945 phosphorylation loop region [posttranslational modification] 675635004946 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635004947 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 675635004948 alpha subunit interface [polypeptide binding]; other site 675635004949 TPP binding site [chemical binding]; other site 675635004950 heterodimer interface [polypeptide binding]; other site 675635004951 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635004952 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635004953 E3 interaction surface; other site 675635004954 lipoyl attachment site [posttranslational modification]; other site 675635004955 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 675635004956 AMP-binding enzyme; Region: AMP-binding; cl15778 675635004957 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635004958 Helix-turn-helix domains; Region: HTH; cl00088 675635004959 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635004960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004961 Predicted acetyltransferase [General function prediction only]; Region: COG3153 675635004962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635004963 Coenzyme A binding pocket [chemical binding]; other site 675635004964 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635004965 Helix-turn-helix domains; Region: HTH; cl00088 675635004966 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 675635004967 Hexamer interface [polypeptide binding]; other site 675635004968 Hexagonal pore residue; other site 675635004969 GAF domain; Region: GAF_2; pfam13185 675635004970 GAF domain; Region: GAF; cl15785 675635004971 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 675635004972 Helix-turn-helix domains; Region: HTH; cl00088 675635004973 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 675635004974 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635004975 catalytic Zn binding site [ion binding]; other site 675635004976 NAD(P) binding site [chemical binding]; other site 675635004977 structural Zn binding site [ion binding]; other site 675635004978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004979 NAD(P) binding site [chemical binding]; other site 675635004980 LDH/MDH dimer interface [polypeptide binding]; other site 675635004981 substrate binding site [chemical binding]; other site 675635004982 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 675635004983 putative hexamer interface [polypeptide binding]; other site 675635004984 putative hexagonal pore; other site 675635004985 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 675635004986 putative hexamer interface [polypeptide binding]; other site 675635004987 putative hexagonal pore; other site 675635004988 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 675635004989 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 675635004990 putative catalytic cysteine [active] 675635004991 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 675635004992 Hexamer interface [polypeptide binding]; other site 675635004993 Hexagonal pore residue; other site 675635004994 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cl01889 675635004995 Hexamer/Pentamer interface [polypeptide binding]; other site 675635004996 central pore; other site 675635004997 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 675635004998 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635004999 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635005000 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 675635005001 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 675635005002 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 675635005003 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 675635005004 hypothetical protein; Provisional; Region: PRK08296 675635005005 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 675635005006 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 675635005007 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 675635005008 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 675635005009 homodimer interface [polypeptide binding]; other site 675635005010 NADP binding site [chemical binding]; other site 675635005011 substrate binding site [chemical binding]; other site 675635005012 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 675635005013 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 675635005014 substrate binding site [chemical binding]; other site 675635005015 ATP binding site [chemical binding]; other site 675635005016 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 675635005017 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 675635005018 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 675635005019 putative active site [active] 675635005020 putative substrate binding site [chemical binding]; other site 675635005021 putative cosubstrate binding site; other site 675635005022 catalytic site [active] 675635005023 S-adenosylmethionine synthetase; Validated; Region: PRK05250 675635005024 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 675635005025 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 675635005026 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 675635005027 methionine synthase; Provisional; Region: PRK01207 675635005028 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 675635005029 substrate binding site [chemical binding]; other site 675635005030 THF binding site; other site 675635005031 zinc-binding site [ion binding]; other site 675635005032 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 675635005033 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 675635005034 FAD binding site [chemical binding]; other site 675635005035 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 675635005036 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 675635005037 Helix-turn-helix domains; Region: HTH; cl00088 675635005038 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 675635005039 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 675635005040 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 675635005041 FAD binding site [chemical binding]; other site 675635005042 OpgC protein; Region: OpgC_C; cl00792 675635005043 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635005044 active site 675635005045 catalytic triad [active] 675635005046 oxyanion hole [active] 675635005047 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 675635005048 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635005049 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 675635005050 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 675635005051 active site 675635005052 Zn binding site [ion binding]; other site 675635005053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635005054 putative transporter; Provisional; Region: PRK10504 675635005055 putative substrate translocation pore; other site 675635005056 Cupin domain; Region: Cupin_2; cl09118 675635005057 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 675635005058 classical (c) SDRs; Region: SDR_c; cd05233 675635005059 NAD(P) binding site [chemical binding]; other site 675635005060 active site 675635005061 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 675635005062 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 675635005063 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 675635005064 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 675635005065 active site 675635005066 metal binding site [ion binding]; metal-binding site 675635005067 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635005068 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 675635005069 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 675635005070 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 675635005071 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 675635005072 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 675635005073 HflX GTPase family; Region: HflX; cd01878 675635005074 G1 box; other site 675635005075 GTP/Mg2+ binding site [chemical binding]; other site 675635005076 Switch I region; other site 675635005077 G2 box; other site 675635005078 G3 box; other site 675635005079 Switch II region; other site 675635005080 G4 box; other site 675635005081 G5 box; other site 675635005082 LexA repressor; Validated; Region: PRK00215 675635005083 Helix-turn-helix domains; Region: HTH; cl00088 675635005084 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 675635005085 Catalytic site [active] 675635005086 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 675635005087 putative peptidoglycan binding site; other site 675635005088 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 675635005089 ATP cone domain; Region: ATP-cone; pfam03477 675635005090 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 675635005091 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 675635005092 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 675635005093 active site 675635005094 dimer interface [polypeptide binding]; other site 675635005095 effector binding site; other site 675635005096 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 675635005097 TSCPD domain; Region: TSCPD; cl14834 675635005098 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 675635005099 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635005100 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635005101 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635005102 nudix motif; other site 675635005103 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635005104 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 675635005105 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 675635005106 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635005107 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 675635005108 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 675635005109 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 675635005110 dimer interface [polypeptide binding]; other site 675635005111 active site 675635005112 Phosphopantetheine attachment site; Region: PP-binding; cl09936 675635005113 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 675635005114 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 675635005115 dimer interface [polypeptide binding]; other site 675635005116 active site 675635005117 CoA binding pocket [chemical binding]; other site 675635005118 Acyl transferase domain; Region: Acyl_transf_1; cl08282 675635005119 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 675635005120 Helix-turn-helix domains; Region: HTH; cl00088 675635005121 Pirin-related protein [General function prediction only]; Region: COG1741 675635005122 Cupin domain; Region: Cupin_2; cl09118 675635005123 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 675635005124 DNA-binding site [nucleotide binding]; DNA binding site 675635005125 RNA-binding motif; other site 675635005126 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 675635005127 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 675635005128 dimer interface [polypeptide binding]; other site 675635005129 TPP-binding site [chemical binding]; other site 675635005130 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 675635005131 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 675635005132 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 675635005133 dimer interface [polypeptide binding]; other site 675635005134 catalytic triad [active] 675635005135 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 675635005136 active site 675635005137 substrate binding pocket [chemical binding]; other site 675635005138 homodimer interaction site [polypeptide binding]; other site 675635005139 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 675635005140 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 675635005141 active site 675635005142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635005143 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635005144 active site 675635005145 catalytic tetrad [active] 675635005146 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 675635005147 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635005148 NIPSNAP; Region: NIPSNAP; pfam07978 675635005149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005150 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 675635005151 NAD(P) binding site [chemical binding]; other site 675635005152 Cupin domain; Region: Cupin_2; cl09118 675635005153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635005154 Walker A motif; other site 675635005155 ATP binding site [chemical binding]; other site 675635005156 Walker B motif; other site 675635005157 arginine finger; other site 675635005158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635005159 Integrase core domain; Region: rve; cl01316 675635005160 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 675635005161 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 675635005162 active site 675635005163 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 675635005164 active site 675635005165 substrate binding pocket [chemical binding]; other site 675635005166 homodimer interaction site [polypeptide binding]; other site 675635005167 Cupin domain; Region: Cupin_2; cl09118 675635005168 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 675635005169 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635005170 NAD binding site [chemical binding]; other site 675635005171 catalytic residues [active] 675635005172 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635005173 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 675635005174 NAD(P) binding site [chemical binding]; other site 675635005175 catalytic residues [active] 675635005176 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 675635005177 Transcriptional regulators [Transcription]; Region: PurR; COG1609 675635005178 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 675635005179 DNA binding site [nucleotide binding] 675635005180 domain linker motif; other site 675635005181 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 675635005182 dimerization interface [polypeptide binding]; other site 675635005183 ligand binding site [chemical binding]; other site 675635005184 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 675635005185 ATP binding site [chemical binding]; other site 675635005186 substrate binding site [chemical binding]; other site 675635005187 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 675635005188 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 675635005189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635005190 active site 675635005191 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635005192 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635005193 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635005194 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635005195 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 675635005196 active site 675635005197 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635005198 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635005199 Flavin Reductases; Region: FlaRed; cl00801 675635005200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 675635005201 Helix-turn-helix domains; Region: HTH; cl00088 675635005202 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 675635005203 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635005204 NIPSNAP; Region: NIPSNAP; pfam07978 675635005205 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635005206 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635005207 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635005208 phosphate binding site [ion binding]; other site 675635005209 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 675635005210 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 675635005211 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 675635005212 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 675635005213 active site 675635005214 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 675635005215 active site 675635005216 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635005217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635005218 dimer interface [polypeptide binding]; other site 675635005219 conserved gate region; other site 675635005220 putative PBP binding loops; other site 675635005221 ABC-ATPase subunit interface; other site 675635005222 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635005223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635005224 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635005225 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 675635005226 Walker A/P-loop; other site 675635005227 ATP binding site [chemical binding]; other site 675635005228 Q-loop/lid; other site 675635005229 ABC transporter signature motif; other site 675635005230 Walker B; other site 675635005231 D-loop; other site 675635005232 H-loop/switch region; other site 675635005233 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635005234 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635005235 Walker A/P-loop; other site 675635005236 ATP binding site [chemical binding]; other site 675635005237 Q-loop/lid; other site 675635005238 ABC transporter signature motif; other site 675635005239 Walker B; other site 675635005240 D-loop; other site 675635005241 H-loop/switch region; other site 675635005242 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635005243 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635005244 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635005245 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635005246 active site 675635005247 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635005248 non-prolyl cis peptide bond; other site 675635005249 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635005250 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635005251 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 675635005252 NADH(P)-binding; Region: NAD_binding_10; pfam13460 675635005253 NAD binding site [chemical binding]; other site 675635005254 substrate binding site [chemical binding]; other site 675635005255 putative active site [active] 675635005256 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635005257 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 675635005258 dimer interface [polypeptide binding]; other site 675635005259 active site 675635005260 non-prolyl cis peptide bond; other site 675635005261 insertion regions; other site 675635005262 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635005263 active site 675635005264 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635005265 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635005266 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 675635005267 molybdopterin cofactor binding site; other site 675635005268 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 675635005269 molybdopterin cofactor binding site; other site 675635005270 Helix-turn-helix domains; Region: HTH; cl00088 675635005271 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635005272 dimerization interface [polypeptide binding]; other site 675635005273 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635005274 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 675635005275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005276 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 675635005277 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 675635005278 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635005279 active site residue [active] 675635005280 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635005281 active site residue [active] 675635005282 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635005283 active site 675635005284 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 675635005285 dimer interface [polypeptide binding]; other site 675635005286 non-prolyl cis peptide bond; other site 675635005287 insertion regions; other site 675635005288 FAD binding domain; Region: FAD_binding_4; pfam01565 675635005289 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 675635005290 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 675635005291 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 675635005292 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 675635005293 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 675635005294 Transposase domain (DUF772); Region: DUF772; cl15789 675635005295 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635005296 Transposase domain (DUF772); Region: DUF772; cl15789 675635005297 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 675635005298 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 675635005299 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 675635005300 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 675635005301 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 675635005302 HSP70 interaction site [polypeptide binding]; other site 675635005303 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 675635005304 substrate binding site [polypeptide binding]; other site 675635005305 dimer interface [polypeptide binding]; other site 675635005306 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 675635005307 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 675635005308 Clp amino terminal domain; Region: Clp_N; pfam02861 675635005309 Clp amino terminal domain; Region: Clp_N; pfam02861 675635005310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635005311 Walker A motif; other site 675635005312 ATP binding site [chemical binding]; other site 675635005313 Walker B motif; other site 675635005314 arginine finger; other site 675635005315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635005316 Walker A motif; other site 675635005317 ATP binding site [chemical binding]; other site 675635005318 Walker B motif; other site 675635005319 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 675635005320 thioredoxin 2; Provisional; Region: PRK10996 675635005321 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 675635005322 catalytic residues [active] 675635005323 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 675635005324 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635005325 ligand binding site [chemical binding]; other site 675635005326 flexible hinge region; other site 675635005327 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 675635005328 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635005329 DNA binding residues [nucleotide binding] 675635005330 dimerization interface [polypeptide binding]; other site 675635005331 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635005332 metal-binding site [ion binding] 675635005333 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 675635005334 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635005335 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635005336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635005337 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635005338 putative substrate translocation pore; other site 675635005339 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 675635005340 amphipathic channel; other site 675635005341 Asn-Pro-Ala signature motifs; other site 675635005342 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 675635005343 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 675635005344 active site 675635005345 dimer interface [polypeptide binding]; other site 675635005346 metal binding site [ion binding]; metal-binding site 675635005347 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635005348 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 675635005349 active site 675635005350 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635005351 DNA binding residues [nucleotide binding] 675635005352 dimerization interface [polypeptide binding]; other site 675635005353 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 675635005354 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635005355 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 675635005356 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635005357 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635005358 DNA binding residues [nucleotide binding] 675635005359 Flavin Reductases; Region: FlaRed; cl00801 675635005360 YCII-related domain; Region: YCII; cl00999 675635005361 DoxX; Region: DoxX; cl00976 675635005362 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635005363 classical (c) SDRs; Region: SDR_c; cd05233 675635005364 NAD(P) binding site [chemical binding]; other site 675635005365 active site 675635005366 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635005367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005368 thiolase; Provisional; Region: PRK06158 675635005369 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635005370 active site 675635005371 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635005372 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635005373 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 675635005374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005375 CoA-ligase; Region: Ligase_CoA; cl02894 675635005376 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635005377 Putative cyclase; Region: Cyclase; cl00814 675635005378 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635005379 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 675635005380 classical (c) SDRs; Region: SDR_c; cd05233 675635005381 NAD(P) binding site [chemical binding]; other site 675635005382 active site 675635005383 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635005384 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635005385 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635005386 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635005387 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 675635005388 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 675635005389 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 675635005390 active site 675635005391 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635005392 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635005393 Walker A motif; other site 675635005394 ATP binding site [chemical binding]; other site 675635005395 Walker B motif; other site 675635005396 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 675635005397 Helix-turn-helix domains; Region: HTH; cl00088 675635005398 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635005399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635005400 DNA-binding site [nucleotide binding]; DNA binding site 675635005401 FCD domain; Region: FCD; cl11656 675635005402 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 675635005403 classical (c) SDRs; Region: SDR_c; cd05233 675635005404 NAD(P) binding site [chemical binding]; other site 675635005405 active site 675635005406 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635005407 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635005408 putative NAD(P) binding site [chemical binding]; other site 675635005409 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635005410 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635005411 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635005412 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635005413 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635005414 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635005415 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635005416 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635005417 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 675635005418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005419 NAD(P) binding site [chemical binding]; other site 675635005420 active site 675635005421 Epoxide hydrolase N terminus; Region: EHN; pfam06441 675635005422 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 675635005423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635005424 Walker A motif; other site 675635005425 ATP binding site [chemical binding]; other site 675635005426 Walker B motif; other site 675635005427 arginine finger; other site 675635005428 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 675635005429 metal ion-dependent adhesion site (MIDAS); other site 675635005430 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 675635005431 classical (c) SDRs; Region: SDR_c; cd05233 675635005432 NAD(P) binding site [chemical binding]; other site 675635005433 active site 675635005434 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635005435 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635005436 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 675635005437 Walker A/P-loop; other site 675635005438 ATP binding site [chemical binding]; other site 675635005439 Q-loop/lid; other site 675635005440 ABC transporter signature motif; other site 675635005441 Walker B; other site 675635005442 D-loop; other site 675635005443 H-loop/switch region; other site 675635005444 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 675635005445 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635005446 TM-ABC transporter signature motif; other site 675635005447 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635005448 TM-ABC transporter signature motif; other site 675635005449 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635005450 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 675635005451 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 675635005452 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635005453 catalytic Zn binding site [ion binding]; other site 675635005454 structural Zn binding site [ion binding]; other site 675635005455 tetramer interface [polypeptide binding]; other site 675635005456 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 675635005457 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635005458 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635005459 Helix-turn-helix domains; Region: HTH; cl00088 675635005460 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 675635005461 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 675635005462 Cl- selectivity filter; other site 675635005463 Cl- binding residues [ion binding]; other site 675635005464 pore gating glutamate residue; other site 675635005465 dimer interface [polypeptide binding]; other site 675635005466 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635005467 FOG: CBS domain [General function prediction only]; Region: COG0517 675635005468 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635005469 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635005470 Helix-turn-helix domains; Region: HTH; cl00088 675635005471 WYL domain; Region: WYL; cl14852 675635005472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635005473 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635005474 active site 675635005475 metal binding site [ion binding]; metal-binding site 675635005476 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635005477 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635005478 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 675635005479 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 675635005480 active site 675635005481 dimer interface [polypeptide binding]; other site 675635005482 metal binding site [ion binding]; metal-binding site 675635005483 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 675635005484 active site 1 [active] 675635005485 dimer interface [polypeptide binding]; other site 675635005486 active site 2 [active] 675635005487 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635005488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005489 NAD(P) binding site [chemical binding]; other site 675635005490 active site 675635005491 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 675635005492 active site 675635005493 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635005494 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 675635005495 Helix-turn-helix domains; Region: HTH; cl00088 675635005496 Flavin Reductases; Region: FlaRed; cl00801 675635005497 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635005498 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635005499 DNA binding residues [nucleotide binding] 675635005500 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 675635005501 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635005502 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 675635005503 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635005504 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 675635005505 active site 675635005506 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 675635005507 Walker A/P-loop; other site 675635005508 ATP binding site [chemical binding]; other site 675635005509 ABC transporter; Region: ABC_tran; pfam00005 675635005510 Q-loop/lid; other site 675635005511 ABC transporter signature motif; other site 675635005512 Walker B; other site 675635005513 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 675635005514 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 675635005515 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635005516 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635005517 Short C-terminal domain; Region: SHOCT; cl01373 675635005518 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635005519 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635005520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635005521 active site 675635005522 phosphorylation site [posttranslational modification] 675635005523 intermolecular recognition site; other site 675635005524 dimerization interface [polypeptide binding]; other site 675635005525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635005526 DNA binding residues [nucleotide binding] 675635005527 dimerization interface [polypeptide binding]; other site 675635005528 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 675635005529 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 675635005530 Domain of unknown function (DUF385); Region: DUF385; cl04387 675635005531 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635005532 Ligand Binding Site [chemical binding]; other site 675635005533 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635005534 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635005535 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 675635005536 trimer interface [polypeptide binding]; other site 675635005537 putative metal binding site [ion binding]; other site 675635005538 Predicted membrane protein [Function unknown]; Region: COG2860 675635005539 UPF0126 domain; Region: UPF0126; pfam03458 675635005540 UPF0126 domain; Region: UPF0126; pfam03458 675635005541 glutamate dehydrogenase; Provisional; Region: PRK09414 675635005542 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 675635005543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005544 NAD(P) binding pocket [chemical binding]; other site 675635005545 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635005546 Helix-turn-helix domains; Region: HTH; cl00088 675635005547 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 675635005548 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 675635005549 Helix-turn-helix domains; Region: HTH; cl00088 675635005550 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 675635005551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635005552 active site 675635005553 phosphorylation site [posttranslational modification] 675635005554 intermolecular recognition site; other site 675635005555 dimerization interface [polypeptide binding]; other site 675635005556 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 675635005557 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635005558 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635005559 anti sigma factor interaction site; other site 675635005560 regulatory phosphorylation site [posttranslational modification]; other site 675635005561 CheB methylesterase; Region: CheB_methylest; pfam01339 675635005562 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 675635005563 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 675635005564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005565 PAS domain; Region: PAS_9; pfam13426 675635005566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635005567 putative active site [active] 675635005568 heme pocket [chemical binding]; other site 675635005569 sensory histidine kinase AtoS; Provisional; Region: PRK11360 675635005570 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635005571 anti sigma factor interaction site; other site 675635005572 regulatory phosphorylation site [posttranslational modification]; other site 675635005573 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635005574 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635005575 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635005576 DNA binding residues [nucleotide binding] 675635005577 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635005578 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635005579 ligand binding site [chemical binding]; other site 675635005580 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635005581 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635005582 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635005583 Helix-turn-helix domains; Region: HTH; cl00088 675635005584 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635005585 GAF domain; Region: GAF; cl15785 675635005586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635005587 dimer interface [polypeptide binding]; other site 675635005588 phosphorylation site [posttranslational modification] 675635005589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635005590 ATP binding site [chemical binding]; other site 675635005591 Mg2+ binding site [ion binding]; other site 675635005592 G-X-G motif; other site 675635005593 Response regulator receiver domain; Region: Response_reg; pfam00072 675635005594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635005595 active site 675635005596 phosphorylation site [posttranslational modification] 675635005597 intermolecular recognition site; other site 675635005598 dimerization interface [polypeptide binding]; other site 675635005599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635005600 PAS domain; Region: PAS_9; pfam13426 675635005601 putative active site [active] 675635005602 heme pocket [chemical binding]; other site 675635005603 GAF domain; Region: GAF; cl15785 675635005604 GAF domain; Region: GAF; cl15785 675635005605 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 675635005606 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635005607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635005608 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635005609 anti sigma factor interaction site; other site 675635005610 regulatory phosphorylation site [posttranslational modification]; other site 675635005611 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 675635005612 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 675635005613 Walker A/P-loop; other site 675635005614 ATP binding site [chemical binding]; other site 675635005615 Q-loop/lid; other site 675635005616 ABC transporter signature motif; other site 675635005617 Walker B; other site 675635005618 D-loop; other site 675635005619 H-loop/switch region; other site 675635005620 Cobalt transport protein; Region: CbiQ; cl00463 675635005621 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 675635005622 High-affinity nickel-transport protein; Region: NicO; cl00964 675635005623 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 675635005624 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 675635005625 dimer interface [polypeptide binding]; other site 675635005626 decamer (pentamer of dimers) interface [polypeptide binding]; other site 675635005627 catalytic triad [active] 675635005628 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 675635005629 ATP binding site [chemical binding]; other site 675635005630 substrate binding site [chemical binding]; other site 675635005631 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635005632 catalytic core [active] 675635005633 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 675635005634 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635005635 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 675635005636 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 675635005637 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 675635005638 putative ADP-binding pocket [chemical binding]; other site 675635005639 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635005640 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 675635005641 ANTAR domain; Region: ANTAR; cl04297 675635005642 Predicted membrane protein [Function unknown]; Region: COG5373 675635005643 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 675635005644 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 675635005645 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 675635005646 oxidoreductase; Provisional; Region: PRK06128 675635005647 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 675635005648 NAD binding site [chemical binding]; other site 675635005649 metal binding site [ion binding]; metal-binding site 675635005650 active site 675635005651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635005652 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635005653 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 675635005654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635005655 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635005656 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 675635005657 active site 675635005658 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 675635005659 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 675635005660 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 675635005661 Putative ubiquinol binding site [chemical binding]; other site 675635005662 Low-spin heme (heme b) binding site [chemical binding]; other site 675635005663 D-pathway; other site 675635005664 Putative water exit pathway; other site 675635005665 Binuclear center (heme o3/CuB) [ion binding]; other site 675635005666 K-pathway; other site 675635005667 Putative proton exit pathway; other site 675635005668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635005669 Helix-turn-helix domains; Region: HTH; cl00088 675635005670 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635005671 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635005672 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635005673 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635005674 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635005675 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635005676 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635005677 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635005678 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635005679 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 675635005680 putative NAD(P) binding site [chemical binding]; other site 675635005681 active site 675635005682 putative substrate binding site [chemical binding]; other site 675635005683 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 675635005684 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635005685 NAD binding site [chemical binding]; other site 675635005686 catalytic Zn binding site [ion binding]; other site 675635005687 structural Zn binding site [ion binding]; other site 675635005688 FOG: CBS domain [General function prediction only]; Region: COG0517 675635005689 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 675635005690 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 675635005691 dimanganese center [ion binding]; other site 675635005692 probable methyltransferase; Region: TIGR03438 675635005693 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 675635005694 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 675635005695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005696 putative methyltransferase; Provisional; Region: PRK14968 675635005697 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 675635005698 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635005699 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635005700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635005701 dimer interface [polypeptide binding]; other site 675635005702 conserved gate region; other site 675635005703 putative PBP binding loops; other site 675635005704 ABC-ATPase subunit interface; other site 675635005705 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635005706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635005707 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 675635005708 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635005709 ANTAR domain; Region: ANTAR; cl04297 675635005710 ANTAR domain; Region: ANTAR; cl04297 675635005711 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 675635005712 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635005713 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635005714 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 675635005715 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635005716 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635005717 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635005718 DNA binding residues [nucleotide binding] 675635005719 GAF domain; Region: GAF; cl15785 675635005720 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 675635005721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635005722 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635005723 anti sigma factor interaction site; other site 675635005724 regulatory phosphorylation site [posttranslational modification]; other site 675635005725 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 675635005726 putative hydrophobic ligand binding site [chemical binding]; other site 675635005727 Gas vesicle protein; Region: Gas_vesicle; cl02954 675635005728 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 675635005729 Gas vesicle protein G; Region: GvpG; pfam05120 675635005730 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 675635005731 Gas vesicle protein; Region: Gas_vesicle; cl02954 675635005732 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 675635005733 Gas vesicle protein; Region: Gas_vesicle; cl02954 675635005734 Gas vesicle protein K; Region: GvpK; pfam05121 675635005735 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635005736 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635005737 active site 675635005738 Ferritin-like domain; Region: Ferritin; pfam00210 675635005739 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 675635005740 dimerization interface [polypeptide binding]; other site 675635005741 DPS ferroxidase diiron center [ion binding]; other site 675635005742 ion pore; other site 675635005743 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635005744 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635005745 DinB superfamily; Region: DinB_2; pfam12867 675635005746 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635005747 MULE transposase domain; Region: MULE; pfam10551 675635005748 Low molecular weight phosphatase family; Region: LMWPc; cl00105 675635005749 active site 675635005750 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 675635005751 Membrane transport protein; Region: Mem_trans; cl09117 675635005752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635005753 dimerization interface [polypeptide binding]; other site 675635005754 putative DNA binding site [nucleotide binding]; other site 675635005755 putative Zn2+ binding site [ion binding]; other site 675635005756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635005757 putative substrate translocation pore; other site 675635005758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635005759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635005760 dimerization interface [polypeptide binding]; other site 675635005761 putative DNA binding site [nucleotide binding]; other site 675635005762 putative Zn2+ binding site [ion binding]; other site 675635005763 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 675635005764 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635005765 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 675635005766 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 675635005767 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635005768 Polysulphide reductase, NrfD; Region: NrfD; cl01295 675635005769 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 675635005770 4Fe-4S binding domain; Region: Fer4; cl02805 675635005771 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 675635005772 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635005773 molybdopterin cofactor binding site; other site 675635005774 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635005775 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635005776 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 675635005777 molybdopterin cofactor binding site; other site 675635005778 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 675635005779 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 675635005780 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 675635005781 FAD binding site [chemical binding]; other site 675635005782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005783 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 675635005784 hydrophobic ligand binding site; other site 675635005785 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 675635005786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005787 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 675635005788 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635005789 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635005790 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635005791 DNA binding residues [nucleotide binding] 675635005792 thiamine pyrophosphate protein; Provisional; Region: PRK08273 675635005793 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 675635005794 PYR/PP interface [polypeptide binding]; other site 675635005795 dimer interface [polypeptide binding]; other site 675635005796 tetramer interface [polypeptide binding]; other site 675635005797 TPP binding site [chemical binding]; other site 675635005798 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 675635005799 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 675635005800 TPP-binding site [chemical binding]; other site 675635005801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005802 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 675635005803 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635005804 classical (c) SDRs; Region: SDR_c; cd05233 675635005805 NAD(P) binding site [chemical binding]; other site 675635005806 active site 675635005807 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 675635005808 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635005809 active site 675635005810 catalytic tetrad [active] 675635005811 GAF domain; Region: GAF; cl15785 675635005812 GAF domain; Region: GAF; cl15785 675635005813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635005814 Histidine kinase; Region: HisKA_3; pfam07730 675635005815 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 675635005816 FMN binding site [chemical binding]; other site 675635005817 dimer interface [polypeptide binding]; other site 675635005818 FOG: CBS domain [General function prediction only]; Region: COG0517 675635005819 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635005820 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 675635005821 putative metal binding site [ion binding]; other site 675635005822 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 675635005823 Transglycosylase; Region: Transgly; cl07896 675635005824 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 675635005825 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635005826 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635005827 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635005828 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635005829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005830 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635005831 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635005832 Walker A/P-loop; other site 675635005833 ATP binding site [chemical binding]; other site 675635005834 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 675635005835 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635005836 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 675635005837 enoyl-CoA hydratase; Provisional; Region: PRK08252 675635005838 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635005839 substrate binding site [chemical binding]; other site 675635005840 oxyanion hole (OAH) forming residues; other site 675635005841 trimer interface [polypeptide binding]; other site 675635005842 Sodium:solute symporter family; Region: SSF; cl00456 675635005843 Isochorismatase family; Region: Isochorismatase; pfam00857 675635005844 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 675635005845 catalytic triad [active] 675635005846 conserved cis-peptide bond; other site 675635005847 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635005848 DNA-binding site [nucleotide binding]; DNA binding site 675635005849 UTRA domain; Region: UTRA; cl01230 675635005850 UTRA domain; Region: UTRA; cl01230 675635005851 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635005852 Amidase; Region: Amidase; cl11426 675635005853 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635005854 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635005855 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 675635005856 classical (c) SDRs; Region: SDR_c; cd05233 675635005857 NAD(P) binding site [chemical binding]; other site 675635005858 active site 675635005859 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635005860 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635005861 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635005862 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 675635005863 GAF domain; Region: GAF_2; pfam13185 675635005864 GAF domain; Region: GAF; cl15785 675635005865 Helix-turn-helix domains; Region: HTH; cl00088 675635005866 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 675635005867 AMP-binding enzyme; Region: AMP-binding; cl15778 675635005868 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 675635005869 The A subunit of Uncharacterized proteins with similarity to Protocatechuate 4,5-dioxygenase (LigAB); Region: LigA_like_1; cd07925 675635005870 putative dimer interface [polypeptide binding]; other site 675635005871 putative tetramer interface [polypeptide binding]; other site 675635005872 putative active site [active] 675635005873 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 675635005874 active site 675635005875 metal binding site [ion binding]; metal-binding site 675635005876 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 675635005877 putative active site [active] 675635005878 catalytic triad [active] 675635005879 putative dimer interface [polypeptide binding]; other site 675635005880 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 675635005881 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635005882 active site 675635005883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635005884 DNA-binding site [nucleotide binding]; DNA binding site 675635005885 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635005886 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635005887 active site 675635005888 catalytic tetrad [active] 675635005889 Helix-turn-helix domains; Region: HTH; cl00088 675635005890 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635005891 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635005892 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635005893 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635005894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635005895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635005896 Helix-turn-helix domains; Region: HTH; cl00088 675635005897 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 675635005898 iron-sulfur cluster [ion binding]; other site 675635005899 [2Fe-2S] cluster binding site [ion binding]; other site 675635005900 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635005901 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 675635005902 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 675635005903 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 675635005904 active site 675635005905 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635005906 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 675635005907 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635005908 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635005909 active site 675635005910 metal binding site [ion binding]; metal-binding site 675635005911 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635005912 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635005913 Walker A/P-loop; other site 675635005914 ATP binding site [chemical binding]; other site 675635005915 Q-loop/lid; other site 675635005916 ABC transporter signature motif; other site 675635005917 Walker B; other site 675635005918 D-loop; other site 675635005919 H-loop/switch region; other site 675635005920 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635005921 TM-ABC transporter signature motif; other site 675635005922 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635005923 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 675635005924 ligand binding site [chemical binding]; other site 675635005925 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635005926 TM-ABC transporter signature motif; other site 675635005927 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635005928 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635005929 Walker A/P-loop; other site 675635005930 ATP binding site [chemical binding]; other site 675635005931 Q-loop/lid; other site 675635005932 ABC transporter signature motif; other site 675635005933 Walker B; other site 675635005934 D-loop; other site 675635005935 H-loop/switch region; other site 675635005936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635005937 Helix-turn-helix domains; Region: HTH; cl00088 675635005938 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635005939 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 675635005940 Helix-turn-helix domains; Region: HTH; cl00088 675635005941 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 675635005942 dimerization interface [polypeptide binding]; other site 675635005943 substrate binding pocket [chemical binding]; other site 675635005944 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 675635005945 RNA/DNA hybrid binding site [nucleotide binding]; other site 675635005946 active site 675635005947 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635005948 Helix-turn-helix domains; Region: HTH; cl00088 675635005949 thiolase; Provisional; Region: PRK06158 675635005950 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635005951 active site 675635005952 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635005953 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 675635005954 Putative cyclase; Region: Cyclase; cl00814 675635005955 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635005956 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635005957 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635005958 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635005959 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635005960 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635005961 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635005962 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635005963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635005964 DNA-binding site [nucleotide binding]; DNA binding site 675635005965 FCD domain; Region: FCD; cl11656 675635005966 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635005967 enoyl-CoA hydratase; Provisional; Region: PRK09245 675635005968 substrate binding site [chemical binding]; other site 675635005969 oxyanion hole (OAH) forming residues; other site 675635005970 trimer interface [polypeptide binding]; other site 675635005971 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 675635005972 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635005973 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635005974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635005975 mycothione reductase; Reviewed; Region: PRK07846 675635005976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635005977 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635005978 Helix-turn-helix domains; Region: HTH; cl00088 675635005979 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635005980 dimerization interface [polypeptide binding]; other site 675635005981 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 675635005982 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 675635005983 Putative cyclase; Region: Cyclase; cl00814 675635005984 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635005985 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 675635005986 NAD binding site [chemical binding]; other site 675635005987 catalytic residues [active] 675635005988 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 675635005989 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 675635005990 active site 1 [active] 675635005991 dimer interface [polypeptide binding]; other site 675635005992 hexamer interface [polypeptide binding]; other site 675635005993 active site 2 [active] 675635005994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005995 NAD(P) binding site [chemical binding]; other site 675635005996 active site 675635005997 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 675635005998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635005999 hypothetical protein; Provisional; Region: PRK08296 675635006000 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 675635006001 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 675635006002 OsmC-like protein; Region: OsmC; cl00767 675635006003 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 675635006004 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635006005 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635006006 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635006007 Helix-turn-helix domains; Region: HTH; cl00088 675635006008 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635006009 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 675635006010 iron-sulfur cluster [ion binding]; other site 675635006011 [2Fe-2S] cluster binding site [ion binding]; other site 675635006012 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635006013 hydrophobic ligand binding site; other site 675635006014 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 675635006015 iron-sulfur cluster [ion binding]; other site 675635006016 [2Fe-2S] cluster binding site [ion binding]; other site 675635006017 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 675635006018 active site 1 [active] 675635006019 dimer interface [polypeptide binding]; other site 675635006020 hexamer interface [polypeptide binding]; other site 675635006021 active site 2 [active] 675635006022 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635006023 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635006024 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635006025 Helix-turn-helix domains; Region: HTH; cl00088 675635006026 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635006027 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 675635006028 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635006029 active site 675635006030 metal binding site [ion binding]; metal-binding site 675635006031 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635006032 active site 675635006033 metal binding site [ion binding]; metal-binding site 675635006034 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 675635006035 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635006036 active site 675635006037 metal binding site [ion binding]; metal-binding site 675635006038 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635006039 active site 675635006040 metal binding site [ion binding]; metal-binding site 675635006041 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 675635006042 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635006043 Helix-turn-helix domains; Region: HTH; cl00088 675635006044 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635006045 Domain of unknown function (DUF385); Region: DUF385; cl04387 675635006046 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 675635006047 substrate binding site [chemical binding]; other site 675635006048 THF binding site; other site 675635006049 zinc-binding site [ion binding]; other site 675635006050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006051 Helix-turn-helix domains; Region: HTH; cl00088 675635006052 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635006053 lipid-transfer protein; Provisional; Region: PRK08256 675635006054 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635006055 active site 675635006056 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635006057 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635006058 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635006059 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 675635006060 classical (c) SDRs; Region: SDR_c; cd05233 675635006061 NAD(P) binding site [chemical binding]; other site 675635006062 active site 675635006063 acyl-CoA synthetase; Validated; Region: PRK06188 675635006064 AMP-binding enzyme; Region: AMP-binding; cl15778 675635006065 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635006066 AMP-binding enzyme; Region: AMP-binding; cl15778 675635006067 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 675635006068 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 675635006069 active site 675635006070 dimer interface [polypeptide binding]; other site 675635006071 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635006072 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 675635006073 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 675635006074 catalytic triad [active] 675635006075 Predicted amidohydrolase [General function prediction only]; Region: COG0388 675635006076 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 675635006077 putative active site [active] 675635006078 catalytic triad [active] 675635006079 putative dimer interface [polypeptide binding]; other site 675635006080 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 675635006081 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 675635006082 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 675635006083 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635006084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635006085 DNA-binding site [nucleotide binding]; DNA binding site 675635006086 FCD domain; Region: FCD; cl11656 675635006087 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 675635006088 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 675635006089 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 675635006090 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 675635006091 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 675635006092 dimer interface [polypeptide binding]; other site 675635006093 active site 675635006094 glycine-pyridoxal phosphate binding site [chemical binding]; other site 675635006095 folate binding site [chemical binding]; other site 675635006096 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 675635006097 lipoyl attachment site [posttranslational modification]; other site 675635006098 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 675635006099 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 675635006100 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 675635006101 glycine dehydrogenase; Provisional; Region: PRK05367 675635006102 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 675635006103 tetramer interface [polypeptide binding]; other site 675635006104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635006105 catalytic residue [active] 675635006106 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 675635006107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635006108 tetramer interface [polypeptide binding]; other site 675635006109 catalytic residue [active] 675635006110 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 675635006111 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635006112 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 675635006113 Walker A/P-loop; other site 675635006114 ATP binding site [chemical binding]; other site 675635006115 Q-loop/lid; other site 675635006116 ABC transporter signature motif; other site 675635006117 Walker B; other site 675635006118 D-loop; other site 675635006119 H-loop/switch region; other site 675635006120 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 675635006121 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635006122 classical (c) SDRs; Region: SDR_c; cd05233 675635006123 NAD(P) binding site [chemical binding]; other site 675635006124 active site 675635006125 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 675635006126 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635006127 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635006128 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635006129 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635006130 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635006131 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635006132 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635006133 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635006134 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635006135 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 675635006136 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635006137 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635006138 enoyl-CoA hydratase; Provisional; Region: PRK06688 675635006139 substrate binding site [chemical binding]; other site 675635006140 oxyanion hole (OAH) forming residues; other site 675635006141 trimer interface [polypeptide binding]; other site 675635006142 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 675635006143 AMP-binding enzyme; Region: AMP-binding; cl15778 675635006144 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635006145 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 675635006146 CrcB-like protein; Region: CRCB; cl09114 675635006147 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635006148 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635006149 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635006150 TM-ABC transporter signature motif; other site 675635006151 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635006152 TM-ABC transporter signature motif; other site 675635006153 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635006154 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 675635006155 Walker A/P-loop; other site 675635006156 ATP binding site [chemical binding]; other site 675635006157 Q-loop/lid; other site 675635006158 ABC transporter signature motif; other site 675635006159 Walker B; other site 675635006160 D-loop; other site 675635006161 H-loop/switch region; other site 675635006162 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635006163 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 675635006164 Walker A/P-loop; other site 675635006165 ATP binding site [chemical binding]; other site 675635006166 Q-loop/lid; other site 675635006167 ABC transporter signature motif; other site 675635006168 Walker B; other site 675635006169 D-loop; other site 675635006170 H-loop/switch region; other site 675635006171 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 675635006172 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635006173 dimer interface [polypeptide binding]; other site 675635006174 active site 675635006175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006176 NAD(P) binding site [chemical binding]; other site 675635006177 active site 675635006178 enoyl-CoA hydratase; Provisional; Region: PRK08252 675635006179 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635006180 substrate binding site [chemical binding]; other site 675635006181 oxyanion hole (OAH) forming residues; other site 675635006182 trimer interface [polypeptide binding]; other site 675635006183 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635006184 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635006185 active site 675635006186 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635006187 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635006188 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635006189 DNA-binding site [nucleotide binding]; DNA binding site 675635006190 FCD domain; Region: FCD; cl11656 675635006191 DNA polymerase kappa; Provisional; Region: PTZ00205 675635006192 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635006193 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635006194 lipid-transfer protein; Provisional; Region: PRK07855 675635006195 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635006196 active site 675635006197 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635006198 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 675635006199 iron-sulfur cluster [ion binding]; other site 675635006200 [2Fe-2S] cluster binding site [ion binding]; other site 675635006201 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635006202 AMP-binding enzyme; Region: AMP-binding; cl15778 675635006203 AMP-binding enzyme; Region: AMP-binding; cl15778 675635006204 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 675635006205 classical (c) SDRs; Region: SDR_c; cd05233 675635006206 NAD(P) binding site [chemical binding]; other site 675635006207 active site 675635006208 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635006209 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635006210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006211 NAD(P) binding site [chemical binding]; other site 675635006212 active site 675635006213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006214 putative substrate translocation pore; other site 675635006215 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635006216 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635006217 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 675635006218 classical (c) SDRs; Region: SDR_c; cd05233 675635006219 NAD(P) binding site [chemical binding]; other site 675635006220 active site 675635006221 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635006222 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635006223 active site 675635006224 metal binding site [ion binding]; metal-binding site 675635006225 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 675635006226 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 675635006227 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 675635006228 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635006229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006230 NAD(P) binding site [chemical binding]; other site 675635006231 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 675635006232 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 675635006233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006234 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 675635006235 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 675635006236 intersubunit interface [polypeptide binding]; other site 675635006237 active site 675635006238 Zn2+ binding site [ion binding]; other site 675635006239 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 675635006240 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635006241 phosphate binding site [ion binding]; other site 675635006242 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 675635006243 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635006244 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635006245 TM-ABC transporter signature motif; other site 675635006246 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635006247 TM-ABC transporter signature motif; other site 675635006248 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635006249 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 675635006250 Walker A/P-loop; other site 675635006251 ATP binding site [chemical binding]; other site 675635006252 Q-loop/lid; other site 675635006253 ABC transporter signature motif; other site 675635006254 Walker B; other site 675635006255 D-loop; other site 675635006256 H-loop/switch region; other site 675635006257 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635006258 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 675635006259 Walker A/P-loop; other site 675635006260 ATP binding site [chemical binding]; other site 675635006261 Q-loop/lid; other site 675635006262 ABC transporter signature motif; other site 675635006263 Walker B; other site 675635006264 D-loop; other site 675635006265 H-loop/switch region; other site 675635006266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006267 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635006268 NAD(P) binding site [chemical binding]; other site 675635006269 active site 675635006270 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635006271 classical (c) SDRs; Region: SDR_c; cd05233 675635006272 NAD(P) binding site [chemical binding]; other site 675635006273 active site 675635006274 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635006275 active site 675635006276 metal binding site [ion binding]; metal-binding site 675635006277 hypothetical protein; Validated; Region: PRK07121 675635006278 Helix-turn-helix domains; Region: HTH; cl00088 675635006279 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 675635006280 C-terminal domain interface [polypeptide binding]; other site 675635006281 sugar binding site [chemical binding]; other site 675635006282 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 675635006283 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635006284 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635006285 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 675635006286 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 675635006287 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635006288 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635006289 Helix-turn-helix domains; Region: HTH; cl00088 675635006290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006291 Helix-turn-helix domains; Region: HTH; cl00088 675635006292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006293 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635006294 putative substrate translocation pore; other site 675635006295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006296 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 675635006297 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 675635006298 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635006299 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 675635006300 AMP-binding enzyme; Region: AMP-binding; cl15778 675635006301 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635006302 benzoate transport; Region: 2A0115; TIGR00895 675635006303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006304 putative substrate translocation pore; other site 675635006305 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635006306 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635006307 substrate binding site [chemical binding]; other site 675635006308 oxyanion hole (OAH) forming residues; other site 675635006309 trimer interface [polypeptide binding]; other site 675635006310 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635006311 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635006312 active site 675635006313 non-prolyl cis peptide bond; other site 675635006314 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635006315 active site 675635006316 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 675635006317 dimer interface [polypeptide binding]; other site 675635006318 non-prolyl cis peptide bond; other site 675635006319 insertion regions; other site 675635006320 Putative cyclase; Region: Cyclase; cl00814 675635006321 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 675635006322 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 675635006323 inhibitor site; inhibition site 675635006324 active site 675635006325 dimer interface [polypeptide binding]; other site 675635006326 catalytic residue [active] 675635006327 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635006328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635006329 DNA-binding site [nucleotide binding]; DNA binding site 675635006330 FCD domain; Region: FCD; cl11656 675635006331 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635006332 Helix-turn-helix domains; Region: HTH; cl00088 675635006333 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635006334 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 675635006335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635006336 Walker A/P-loop; other site 675635006337 ATP binding site [chemical binding]; other site 675635006338 Q-loop/lid; other site 675635006339 ABC transporter signature motif; other site 675635006340 Walker B; other site 675635006341 D-loop; other site 675635006342 H-loop/switch region; other site 675635006343 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635006344 active site 675635006345 DNA binding site [nucleotide binding] 675635006346 Int/Topo IB signature motif; other site 675635006347 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 675635006348 intracellular protease, PfpI family; Region: PfpI; TIGR01382 675635006349 proposed catalytic triad [active] 675635006350 conserved cys residue [active] 675635006351 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 675635006352 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635006353 dimer interface [polypeptide binding]; other site 675635006354 active site 675635006355 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 675635006356 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 675635006357 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 675635006358 active site 675635006359 catalytic site [active] 675635006360 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 675635006361 Fe-S cluster binding site [ion binding]; other site 675635006362 active site 675635006363 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635006364 Protein kinase domain; Region: Pkinase; pfam00069 675635006365 active site 675635006366 ATP binding site [chemical binding]; other site 675635006367 substrate binding site [chemical binding]; other site 675635006368 activation loop (A-loop); other site 675635006369 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 675635006370 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635006371 Helix-turn-helix domains; Region: HTH; cl00088 675635006372 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635006373 MoxR-like ATPases [General function prediction only]; Region: COG0714 675635006374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635006375 Walker A motif; other site 675635006376 ATP binding site [chemical binding]; other site 675635006377 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 675635006378 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 675635006379 metal ion-dependent adhesion site (MIDAS); other site 675635006380 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 675635006381 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 675635006382 putative hydrophobic ligand binding site [chemical binding]; other site 675635006383 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 675635006384 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635006385 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635006386 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635006387 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635006388 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635006389 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635006390 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635006391 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635006392 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 675635006393 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635006394 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 675635006395 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635006396 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635006397 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 675635006398 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 675635006399 XdhC Rossmann domain; Region: XdhC_C; pfam13478 675635006400 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 675635006401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006402 Helix-turn-helix domains; Region: HTH; cl00088 675635006403 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635006404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006405 putative substrate translocation pore; other site 675635006406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006408 putative substrate translocation pore; other site 675635006409 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 675635006410 active site 675635006411 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 675635006412 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635006413 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635006414 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635006415 GAF domain; Region: GAF_2; pfam13185 675635006416 GAF domain; Region: GAF; cl15785 675635006417 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 675635006418 Helix-turn-helix domains; Region: HTH; cl00088 675635006419 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635006420 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635006421 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 675635006422 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635006423 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635006424 classical (c) SDRs; Region: SDR_c; cd05233 675635006425 NAD(P) binding site [chemical binding]; other site 675635006426 active site 675635006427 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635006428 AMP-binding enzyme; Region: AMP-binding; cl15778 675635006429 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635006430 Helix-turn-helix domains; Region: HTH; cl00088 675635006431 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 675635006432 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635006433 classical (c) SDRs; Region: SDR_c; cd05233 675635006434 NAD(P) binding site [chemical binding]; other site 675635006435 active site 675635006436 classical (c) SDRs; Region: SDR_c; cd05233 675635006437 NAD(P) binding site [chemical binding]; other site 675635006438 active site 675635006439 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 675635006440 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635006441 substrate binding site [chemical binding]; other site 675635006442 oxyanion hole (OAH) forming residues; other site 675635006443 trimer interface [polypeptide binding]; other site 675635006444 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635006445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006446 Bifunctional nuclease; Region: DNase-RNase; cl00553 675635006447 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 675635006448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635006449 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635006450 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635006451 catalytic residue [active] 675635006452 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 675635006453 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635006454 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635006455 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635006456 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 675635006457 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 675635006458 classical (c) SDRs; Region: SDR_c; cd05233 675635006459 NAD(P) binding site [chemical binding]; other site 675635006460 active site 675635006461 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 675635006462 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635006463 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 675635006464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006465 putative substrate translocation pore; other site 675635006466 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 675635006467 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635006468 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635006469 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635006470 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 675635006471 putative catalytic site [active] 675635006472 putative metal binding site [ion binding]; other site 675635006473 putative phosphate binding site [ion binding]; other site 675635006474 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 675635006475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006476 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635006477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006478 Helix-turn-helix domains; Region: HTH; cl00088 675635006479 AMP-binding enzyme; Region: AMP-binding; cl15778 675635006480 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 675635006481 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 675635006482 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 675635006483 substrate binding site [chemical binding]; other site 675635006484 dimer interface [polypeptide binding]; other site 675635006485 NADP binding site [chemical binding]; other site 675635006486 catalytic residues [active] 675635006487 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635006488 active site 2 [active] 675635006489 active site 1 [active] 675635006490 enoyl-CoA hydratase; Provisional; Region: PRK06688 675635006491 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635006492 substrate binding site [chemical binding]; other site 675635006493 oxyanion hole (OAH) forming residues; other site 675635006494 trimer interface [polypeptide binding]; other site 675635006495 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006496 Helix-turn-helix domains; Region: HTH; cl00088 675635006497 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 675635006498 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 675635006499 Phenylacetic acid degradation B; Region: PaaB; cl01371 675635006500 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 675635006501 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 675635006502 Domain of unknown function DUF59; Region: DUF59; cl00941 675635006503 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 675635006504 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 675635006505 FAD binding pocket [chemical binding]; other site 675635006506 FAD binding motif [chemical binding]; other site 675635006507 phosphate binding motif [ion binding]; other site 675635006508 beta-alpha-beta structure motif; other site 675635006509 NAD(p) ribose binding residues [chemical binding]; other site 675635006510 NAD binding pocket [chemical binding]; other site 675635006511 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 675635006512 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635006513 catalytic loop [active] 675635006514 iron binding site [ion binding]; other site 675635006515 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 675635006516 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 675635006517 active site 675635006518 catalytic residues [active] 675635006519 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 675635006520 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 675635006521 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 675635006522 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 675635006523 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635006524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635006525 Helix-turn-helix domains; Region: HTH; cl00088 675635006526 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 675635006527 metal binding site 2 [ion binding]; metal-binding site 675635006528 putative DNA binding helix; other site 675635006529 metal binding site 1 [ion binding]; metal-binding site 675635006530 dimer interface [polypeptide binding]; other site 675635006531 structural Zn2+ binding site [ion binding]; other site 675635006532 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 675635006533 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 675635006534 heme binding site [chemical binding]; other site 675635006535 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 675635006536 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 675635006537 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 675635006538 AMP-binding enzyme; Region: AMP-binding; cl15778 675635006539 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635006540 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635006541 Flavin Reductases; Region: FlaRed; cl00801 675635006542 CobD/Cbib protein; Region: CobD_Cbib; cl00561 675635006543 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 675635006544 cobyric acid synthase; Provisional; Region: PRK00784 675635006545 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635006546 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 675635006547 catalytic triad [active] 675635006548 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 675635006549 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635006550 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 675635006551 metal ion-dependent adhesion site (MIDAS); other site 675635006552 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 675635006553 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635006554 Walker A motif; other site 675635006555 ATP binding site [chemical binding]; other site 675635006556 Walker B motif; other site 675635006557 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 675635006558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635006559 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 675635006560 catalytic triad [active] 675635006561 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 675635006562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006563 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 675635006564 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 675635006565 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 675635006566 FMN binding site [chemical binding]; other site 675635006567 dimer interface [polypeptide binding]; other site 675635006568 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 675635006569 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 675635006570 putative dimer interface [polypeptide binding]; other site 675635006571 active site pocket [active] 675635006572 putative cataytic base [active] 675635006573 DNA polymerase IV; Provisional; Region: PRK03348 675635006574 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 675635006575 active site 675635006576 DNA binding site [nucleotide binding] 675635006577 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 675635006578 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635006579 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 675635006580 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635006581 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635006582 active site 675635006583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006584 Helix-turn-helix domains; Region: HTH; cl00088 675635006585 hypothetical protein; Provisional; Region: PRK06834 675635006586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006587 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 675635006588 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 675635006589 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 675635006590 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635006591 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 675635006592 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 675635006593 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 675635006594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635006595 motif II; other site 675635006596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635006597 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635006598 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 675635006599 tetramer interface [polypeptide binding]; other site 675635006600 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 675635006601 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635006602 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 675635006603 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 675635006604 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 675635006605 conserved cys residue [active] 675635006606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635006607 ferredoxin-NADP+ reductase; Region: PLN02852 675635006608 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635006609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635006610 DNA-binding site [nucleotide binding]; DNA binding site 675635006611 FCD domain; Region: FCD; cl11656 675635006612 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 675635006613 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 675635006614 heme bH binding site [chemical binding]; other site 675635006615 intrachain domain interface; other site 675635006616 heme bL binding site [chemical binding]; other site 675635006617 interchain domain interface [polypeptide binding]; other site 675635006618 Qo binding site; other site 675635006619 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 675635006620 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 675635006621 iron-sulfur cluster [ion binding]; other site 675635006622 [2Fe-2S] cluster binding site [ion binding]; other site 675635006623 Cytochrome c; Region: Cytochrom_C; cl11414 675635006624 Cytochrome c; Region: Cytochrom_C; cl11414 675635006625 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 675635006626 Subunit I/III interface [polypeptide binding]; other site 675635006627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 675635006628 active site 675635006629 phosphorylation site [posttranslational modification] 675635006630 intermolecular recognition site; other site 675635006631 dimerization interface [polypeptide binding]; other site 675635006632 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 675635006633 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 675635006634 Helix-turn-helix domains; Region: HTH; cl00088 675635006635 hypothetical protein; Validated; Region: PRK07883 675635006636 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 675635006637 active site 675635006638 catalytic site [active] 675635006639 substrate binding site [chemical binding]; other site 675635006640 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 675635006641 GIY-YIG motif/motif A; other site 675635006642 active site 675635006643 catalytic site [active] 675635006644 putative DNA binding site [nucleotide binding]; other site 675635006645 metal binding site [ion binding]; metal-binding site 675635006646 YacP-like NYN domain; Region: NYN_YacP; cl01491 675635006647 NlpC/P60 family; Region: NLPC_P60; cl11438 675635006648 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635006649 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 675635006650 AMP-binding enzyme; Region: AMP-binding; cl15778 675635006651 AMP-binding enzyme; Region: AMP-binding; cl15778 675635006652 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 675635006653 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 675635006654 active site 675635006655 metal binding site [ion binding]; metal-binding site 675635006656 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 675635006657 putative hydrophobic ligand binding site [chemical binding]; other site 675635006658 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 675635006659 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 675635006660 P loop; other site 675635006661 Nucleotide binding site [chemical binding]; other site 675635006662 DTAP/Switch II; other site 675635006663 Switch I; other site 675635006664 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 675635006665 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 675635006666 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 675635006667 putative acyl-acceptor binding pocket; other site 675635006668 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 675635006669 Protein kinase domain; Region: Pkinase; pfam00069 675635006670 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635006671 active site 675635006672 ATP binding site [chemical binding]; other site 675635006673 substrate binding site [chemical binding]; other site 675635006674 activation loop (A-loop); other site 675635006675 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635006676 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635006677 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 675635006678 substrate binding pocket [chemical binding]; other site 675635006679 substrate-Mg2+ binding site; other site 675635006680 aspartate-rich region 1; other site 675635006681 aspartate-rich region 2; other site 675635006682 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 675635006683 phytoene desaturase; Region: crtI_fam; TIGR02734 675635006684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006685 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 675635006686 substrate binding pocket [chemical binding]; other site 675635006687 chain length determination region; other site 675635006688 substrate-Mg2+ binding site; other site 675635006689 catalytic residues [active] 675635006690 aspartate-rich region 1; other site 675635006691 active site lid residues [active] 675635006692 aspartate-rich region 2; other site 675635006693 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 675635006694 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 675635006695 FAD binding site [chemical binding]; other site 675635006696 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 675635006697 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 675635006698 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635006699 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 675635006700 P-loop; other site 675635006701 Magnesium ion binding site [ion binding]; other site 675635006702 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635006703 Magnesium ion binding site [ion binding]; other site 675635006704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006705 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 675635006706 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 675635006707 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 675635006708 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 675635006709 MoxR-like ATPases [General function prediction only]; Region: COG0714 675635006710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635006711 ATP binding site [chemical binding]; other site 675635006712 Walker A motif; other site 675635006713 Walker B motif; other site 675635006714 arginine finger; other site 675635006715 cell division protein MraZ; Reviewed; Region: PRK00326 675635006716 MraZ protein; Region: MraZ; pfam02381 675635006717 MraZ protein; Region: MraZ; pfam02381 675635006718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006719 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 675635006720 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 675635006721 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635006722 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 675635006723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 675635006724 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 675635006725 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 675635006726 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 675635006727 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 675635006728 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 675635006729 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 675635006730 Mg++ binding site [ion binding]; other site 675635006731 putative catalytic motif [active] 675635006732 putative substrate binding site [chemical binding]; other site 675635006733 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 675635006734 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 675635006735 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 675635006736 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 675635006737 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 675635006738 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 675635006739 homodimer interface [polypeptide binding]; other site 675635006740 active site 675635006741 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 675635006742 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 675635006743 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 675635006744 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 675635006745 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 675635006746 Cell division protein FtsQ; Region: FtsQ; pfam03799 675635006747 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 675635006748 nucleotide binding site [chemical binding]; other site 675635006749 SulA interaction site; other site 675635006750 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 675635006751 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 675635006752 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 675635006753 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 675635006754 catalytic residue [active] 675635006755 Protein of unknown function (DUF552); Region: DUF552; cl00775 675635006756 YGGT family; Region: YGGT; cl00508 675635006757 DivIVA protein; Region: DivIVA; pfam05103 675635006758 DivIVA domain; Region: DivI1A_domain; TIGR03544 675635006759 Plant ATP synthase F0; Region: YMF19; cl07975 675635006760 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 675635006761 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 675635006762 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 675635006763 HIGH motif; other site 675635006764 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 675635006765 active site 675635006766 KMSKS motif; other site 675635006767 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 675635006768 tRNA binding surface [nucleotide binding]; other site 675635006769 anticodon binding site; other site 675635006770 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 675635006771 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 675635006772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006773 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 675635006774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 675635006775 active site 675635006776 phosphorylation site [posttranslational modification] 675635006777 intermolecular recognition site; other site 675635006778 dimerization interface [polypeptide binding]; other site 675635006779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635006780 DNA binding residues [nucleotide binding] 675635006781 Putative sensor; Region: Sensor; pfam13796 675635006782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635006783 Histidine kinase; Region: HisKA_3; pfam07730 675635006784 CAAX protease self-immunity; Region: Abi; cl00558 675635006785 Acyltransferase family; Region: Acyl_transf_3; pfam01757 675635006786 potassium/proton antiporter; Reviewed; Region: PRK05326 675635006787 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 675635006788 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 675635006789 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 675635006790 active site 675635006791 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635006792 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635006793 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 675635006794 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 675635006795 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 675635006796 generic binding surface II; other site 675635006797 generic binding surface I; other site 675635006798 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 675635006799 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635006800 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635006801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006802 putative substrate translocation pore; other site 675635006803 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 675635006804 PaaX-like protein; Region: PaaX; pfam07848 675635006805 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 675635006806 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635006807 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 675635006808 inhibitor-cofactor binding pocket; inhibition site 675635006809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635006810 catalytic residue [active] 675635006811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635006812 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 675635006813 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635006814 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635006815 catalytic residue [active] 675635006816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635006817 biotin synthase; Validated; Region: PRK06256 675635006818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635006819 FeS/SAM binding site; other site 675635006820 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 675635006821 PemK-like protein; Region: PemK; cl00995 675635006822 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 675635006823 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635006824 nudix motif; other site 675635006825 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635006826 Quinolinate synthetase A protein; Region: NadA; cl00420 675635006827 L-aspartate oxidase; Provisional; Region: PRK07804 675635006828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006829 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 675635006830 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 675635006831 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 675635006832 dimerization interface [polypeptide binding]; other site 675635006833 active site 675635006834 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 675635006835 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 675635006836 NAD binding site [chemical binding]; other site 675635006837 dimerization interface [polypeptide binding]; other site 675635006838 product binding site; other site 675635006839 substrate binding site [chemical binding]; other site 675635006840 zinc binding site [ion binding]; other site 675635006841 catalytic residues [active] 675635006842 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 675635006843 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635006844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635006845 homodimer interface [polypeptide binding]; other site 675635006846 catalytic residue [active] 675635006847 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 675635006848 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 675635006849 putative active site pocket [active] 675635006850 4-fold oligomerization interface [polypeptide binding]; other site 675635006851 metal binding residues [ion binding]; metal-binding site 675635006852 3-fold/trimer interface [polypeptide binding]; other site 675635006853 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 675635006854 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 675635006855 putative active site [active] 675635006856 oxyanion strand; other site 675635006857 catalytic triad [active] 675635006858 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 675635006859 substrate binding site [chemical binding]; other site 675635006860 THF binding site; other site 675635006861 zinc-binding site [ion binding]; other site 675635006862 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 675635006863 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 675635006864 catalytic residues [active] 675635006865 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 675635006866 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 675635006867 substrate binding site [chemical binding]; other site 675635006868 glutamase interaction surface [polypeptide binding]; other site 675635006869 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 675635006870 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 675635006871 Histidine kinase; Region: HisKA_3; pfam07730 675635006872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635006873 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635006874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635006875 active site 675635006876 phosphorylation site [posttranslational modification] 675635006877 intermolecular recognition site; other site 675635006878 dimerization interface [polypeptide binding]; other site 675635006879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635006880 DNA binding residues [nucleotide binding] 675635006881 dimerization interface [polypeptide binding]; other site 675635006882 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006883 Helix-turn-helix domains; Region: HTH; cl00088 675635006884 anthranilate synthase component I; Provisional; Region: PRK13571 675635006885 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 675635006886 chorismate binding enzyme; Region: Chorismate_bind; cl10555 675635006887 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 675635006888 active site 675635006889 ribulose/triose binding site [chemical binding]; other site 675635006890 phosphate binding site [ion binding]; other site 675635006891 substrate (anthranilate) binding pocket [chemical binding]; other site 675635006892 product (indole) binding pocket [chemical binding]; other site 675635006893 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 675635006894 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 675635006895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635006896 catalytic residue [active] 675635006897 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 675635006898 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 675635006899 substrate binding site [chemical binding]; other site 675635006900 active site 675635006901 catalytic residues [active] 675635006902 heterodimer interface [polypeptide binding]; other site 675635006903 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 675635006904 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 675635006905 pyruvate kinase; Provisional; Region: PRK06247 675635006906 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 675635006907 domain interfaces; other site 675635006908 active site 675635006909 acyl-CoA thioesterase II; Region: tesB; TIGR00189 675635006910 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 675635006911 active site 675635006912 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 675635006913 catalytic triad [active] 675635006914 dimer interface [polypeptide binding]; other site 675635006915 OsmC-like protein; Region: OsmC; cl00767 675635006916 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 675635006917 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 675635006918 homodimer interface [polypeptide binding]; other site 675635006919 substrate-cofactor binding pocket; other site 675635006920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635006921 catalytic residue [active] 675635006922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006923 malate dehydrogenase; Provisional; Region: PRK05442 675635006924 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 675635006925 NAD(P) binding site [chemical binding]; other site 675635006926 dimer interface [polypeptide binding]; other site 675635006927 malate binding site [chemical binding]; other site 675635006928 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 675635006929 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 675635006930 putative active site [active] 675635006931 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 675635006932 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 675635006933 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 675635006934 catalytic site [active] 675635006935 active site 675635006936 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 675635006937 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 675635006938 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 675635006939 active site 675635006940 catalytic site [active] 675635006941 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 675635006942 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 675635006943 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 675635006944 active site 675635006945 catalytic site [active] 675635006946 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635006947 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 675635006948 nucleotide binding site/active site [active] 675635006949 HIT family signature motif; other site 675635006950 catalytic residue [active] 675635006951 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635006952 catalytic core [active] 675635006953 H+ Antiporter protein; Region: 2A0121; TIGR00900 675635006954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006955 transcription termination factor Rho; Provisional; Region: PRK12678 675635006956 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635006957 metal binding site [ion binding]; metal-binding site 675635006958 active site 675635006959 I-site; other site 675635006960 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635006961 metal binding site [ion binding]; metal-binding site 675635006962 active site 675635006963 I-site; other site 675635006964 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 675635006965 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 675635006966 TPP-binding site; other site 675635006967 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 675635006968 PYR/PP interface [polypeptide binding]; other site 675635006969 dimer interface [polypeptide binding]; other site 675635006970 TPP binding site [chemical binding]; other site 675635006971 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635006972 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635006973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635006974 active site 675635006975 phosphorylation site [posttranslational modification] 675635006976 intermolecular recognition site; other site 675635006977 dimerization interface [polypeptide binding]; other site 675635006978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635006979 DNA binding site [nucleotide binding] 675635006980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 675635006981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635006982 dimer interface [polypeptide binding]; other site 675635006983 phosphorylation site [posttranslational modification] 675635006984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635006985 ATP binding site [chemical binding]; other site 675635006986 Mg2+ binding site [ion binding]; other site 675635006987 G-X-G motif; other site 675635006988 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 675635006989 catalytic site [active] 675635006990 putative active site [active] 675635006991 putative substrate binding site [chemical binding]; other site 675635006992 HRDC domain; Region: HRDC; cl02578 675635006993 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635006994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635006995 active site 675635006996 phosphorylation site [posttranslational modification] 675635006997 intermolecular recognition site; other site 675635006998 dimerization interface [polypeptide binding]; other site 675635006999 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635007000 DNA binding residues [nucleotide binding] 675635007001 dimerization interface [polypeptide binding]; other site 675635007002 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 675635007003 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 675635007004 substrate binding site [chemical binding]; other site 675635007005 active site 675635007006 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 675635007007 Chlorite dismutase; Region: Chlor_dismutase; cl01280 675635007008 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635007009 dimerization interface [polypeptide binding]; other site 675635007010 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 675635007011 SelR domain; Region: SelR; pfam01641 675635007012 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 675635007013 nucleotide binding site [chemical binding]; other site 675635007014 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 675635007015 Asp23 family; Region: Asp23; cl00574 675635007016 Small T antigen; Reviewed; Region: PHA03102 675635007017 Asp23 family; Region: Asp23; cl00574 675635007018 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 675635007019 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 675635007020 ABC-ATPase subunit interface; other site 675635007021 dimer interface [polypeptide binding]; other site 675635007022 putative PBP binding regions; other site 675635007023 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 675635007024 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 675635007025 dimer interface [polypeptide binding]; other site 675635007026 putative PBP binding regions; other site 675635007027 ABC-ATPase subunit interface; other site 675635007028 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 675635007029 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 675635007030 Walker A/P-loop; other site 675635007031 ATP binding site [chemical binding]; other site 675635007032 Q-loop/lid; other site 675635007033 ABC transporter signature motif; other site 675635007034 Walker B; other site 675635007035 D-loop; other site 675635007036 H-loop/switch region; other site 675635007037 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 675635007038 Phosphate transporter family; Region: PHO4; cl00396 675635007039 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 675635007040 FAD binding domain; Region: FAD_binding_4; pfam01565 675635007041 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635007042 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 675635007043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007044 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 675635007045 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 675635007046 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 675635007047 acyl-CoA synthetase; Validated; Region: PRK07798 675635007048 AMP-binding enzyme; Region: AMP-binding; cl15778 675635007049 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635007050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007051 NAD(P) binding site [chemical binding]; other site 675635007052 active site 675635007053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635007054 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635007055 active site 675635007056 enoyl-CoA hydratase; Region: PLN02864 675635007057 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635007058 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 675635007059 dimer interaction site [polypeptide binding]; other site 675635007060 substrate-binding tunnel; other site 675635007061 active site 675635007062 catalytic site [active] 675635007063 substrate binding site [chemical binding]; other site 675635007064 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635007065 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635007066 Phosphotransferase enzyme family; Region: APH; pfam01636 675635007067 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635007068 active site 675635007069 ATP binding site [chemical binding]; other site 675635007070 Low molecular weight phosphatase family; Region: LMWPc; cd00115 675635007071 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 675635007072 active site 675635007073 hypothetical protein; Provisional; Region: PRK07908 675635007074 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635007075 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635007076 catalytic residue [active] 675635007077 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635007078 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635007079 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 675635007080 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 675635007081 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 675635007082 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 675635007083 Putative zinc ribbon domain; Region: DUF164; pfam02591 675635007084 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635007085 catalytic core [active] 675635007086 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 675635007087 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 675635007088 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 675635007089 Domain of unknown function (DUF222); Region: DUF222; pfam02720 675635007090 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 675635007091 active site 675635007092 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 675635007093 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 675635007094 putative active site [active] 675635007095 putative NTP binding site [chemical binding]; other site 675635007096 putative nucleic acid binding site [nucleotide binding]; other site 675635007097 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635007098 active site 675635007099 catalytic triad [active] 675635007100 oxyanion hole [active] 675635007101 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635007102 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 675635007103 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635007104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635007105 DNA-binding site [nucleotide binding]; DNA binding site 675635007106 Helix-turn-helix domains; Region: HTH; cl00088 675635007107 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 675635007108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007109 hypothetical protein; Provisional; Region: PRK07588 675635007110 phosphoenolpyruvate synthase; Validated; Region: PRK06241 675635007111 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 675635007112 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 675635007113 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 675635007114 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635007115 G1 box; other site 675635007116 GTP/Mg2+ binding site [chemical binding]; other site 675635007117 G2 box; other site 675635007118 Switch I region; other site 675635007119 G3 box; other site 675635007120 Switch II region; other site 675635007121 G4 box; other site 675635007122 G5 box; other site 675635007123 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 675635007124 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 675635007125 active site 675635007126 catalytic triad [active] 675635007127 oxyanion hole [active] 675635007128 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 675635007129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635007130 motif II; other site 675635007131 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635007132 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635007133 active site 675635007134 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 675635007135 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635007136 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 675635007137 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635007138 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635007139 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 675635007140 putative hydrophobic ligand binding site [chemical binding]; other site 675635007141 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635007142 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635007143 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 675635007144 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635007145 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635007146 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635007147 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635007148 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 675635007149 Walker A/P-loop; other site 675635007150 ATP binding site [chemical binding]; other site 675635007151 Q-loop/lid; other site 675635007152 ABC transporter signature motif; other site 675635007153 Walker B; other site 675635007154 D-loop; other site 675635007155 H-loop/switch region; other site 675635007156 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 675635007157 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635007158 TM-ABC transporter signature motif; other site 675635007159 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635007160 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635007161 ligand binding site [chemical binding]; other site 675635007162 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 675635007163 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635007164 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635007165 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635007166 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635007167 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635007168 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635007169 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635007170 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635007171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007172 NAD(P) binding site [chemical binding]; other site 675635007173 active site 675635007174 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 675635007175 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 675635007176 amidase; Provisional; Region: PRK07486 675635007177 Amidase; Region: Amidase; cl11426 675635007178 Creatinine amidohydrolase; Region: Creatininase; cl00618 675635007179 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 675635007180 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 675635007181 [2Fe-2S] cluster binding site [ion binding]; other site 675635007182 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635007183 hydrophobic ligand binding site; other site 675635007184 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 675635007185 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 675635007186 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635007187 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635007188 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635007189 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635007190 DNA binding residues [nucleotide binding] 675635007191 dimerization interface [polypeptide binding]; other site 675635007192 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 675635007193 active site 675635007194 catalytic tetrad [active] 675635007195 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635007196 Helix-turn-helix domains; Region: HTH; cl00088 675635007197 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635007198 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 675635007199 Dak1 domain; Region: Dak1; pfam02733 675635007200 DAK2 domain; Region: Dak2; cl03685 675635007201 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 675635007202 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 675635007203 dimerization domain swap beta strand [polypeptide binding]; other site 675635007204 regulatory protein interface [polypeptide binding]; other site 675635007205 active site 675635007206 regulatory phosphorylation site [posttranslational modification]; other site 675635007207 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 675635007208 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 675635007209 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 675635007210 Flavin Reductases; Region: FlaRed; cl00801 675635007211 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635007212 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 675635007213 NAD(P) binding site [chemical binding]; other site 675635007214 catalytic residues [active] 675635007215 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 675635007216 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 675635007217 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635007218 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635007219 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635007220 DNA binding residues [nucleotide binding] 675635007221 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 675635007222 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 675635007223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635007224 non-specific DNA binding site [nucleotide binding]; other site 675635007225 salt bridge; other site 675635007226 sequence-specific DNA binding site [nucleotide binding]; other site 675635007227 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 675635007228 dimerization interface [polypeptide binding]; other site 675635007229 putative tRNAtyr binding site [nucleotide binding]; other site 675635007230 putative active site [active] 675635007231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007232 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635007233 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635007234 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 675635007235 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635007236 dimerization interface [polypeptide binding]; other site 675635007237 putative DNA binding site [nucleotide binding]; other site 675635007238 putative Zn2+ binding site [ion binding]; other site 675635007239 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 675635007240 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 675635007241 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 675635007242 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 675635007243 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 675635007244 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 675635007245 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 675635007246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635007247 ATP binding site [chemical binding]; other site 675635007248 putative Mg++ binding site [ion binding]; other site 675635007249 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 675635007250 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635007251 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635007252 catalytic residue [active] 675635007253 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 675635007254 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 675635007255 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 675635007256 putative ligand binding site [chemical binding]; other site 675635007257 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635007258 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635007259 Walker A/P-loop; other site 675635007260 ATP binding site [chemical binding]; other site 675635007261 Q-loop/lid; other site 675635007262 ABC transporter signature motif; other site 675635007263 Walker B; other site 675635007264 D-loop; other site 675635007265 H-loop/switch region; other site 675635007266 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 675635007267 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635007268 TM-ABC transporter signature motif; other site 675635007269 Helix-turn-helix domains; Region: HTH; cl00088 675635007270 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 675635007271 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 675635007272 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 675635007273 putative nucleotide binding site [chemical binding]; other site 675635007274 putative catalytic residues [active] 675635007275 putative Mg ion binding site [ion binding]; other site 675635007276 putative aspartate binding site [chemical binding]; other site 675635007277 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635007278 AMP-binding enzyme; Region: AMP-binding; cl15778 675635007279 Phosphopantetheine attachment site; Region: PP-binding; cl09936 675635007280 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 675635007281 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635007282 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635007283 putative trimer interface [polypeptide binding]; other site 675635007284 putative CoA binding site [chemical binding]; other site 675635007285 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 675635007286 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635007287 inhibitor-cofactor binding pocket; inhibition site 675635007288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635007289 catalytic residue [active] 675635007290 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 675635007291 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 675635007292 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 675635007293 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 675635007294 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 675635007295 structural tetrad; other site 675635007296 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635007297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635007298 active site 675635007299 phosphorylation site [posttranslational modification] 675635007300 intermolecular recognition site; other site 675635007301 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635007302 DNA binding residues [nucleotide binding] 675635007303 dimerization interface [polypeptide binding]; other site 675635007304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635007305 Histidine kinase; Region: HisKA_3; pfam07730 675635007306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635007307 ATP binding site [chemical binding]; other site 675635007308 Mg2+ binding site [ion binding]; other site 675635007309 G-X-G motif; other site 675635007310 Acyltransferase family; Region: Acyl_transf_3; pfam01757 675635007311 NMT1-like family; Region: NMT1_2; cl15260 675635007312 NMT1/THI5 like; Region: NMT1; pfam09084 675635007313 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 675635007314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635007315 ABC-ATPase subunit interface; other site 675635007316 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 675635007317 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 675635007318 Walker A/P-loop; other site 675635007319 ATP binding site [chemical binding]; other site 675635007320 Q-loop/lid; other site 675635007321 ABC transporter signature motif; other site 675635007322 Walker B; other site 675635007323 D-loop; other site 675635007324 H-loop/switch region; other site 675635007325 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 675635007326 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 675635007327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 675635007328 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 675635007329 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 675635007330 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 675635007331 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 675635007332 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 675635007333 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 675635007334 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 675635007335 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 675635007336 Precorrin-8X methylmutase; Region: CbiC; pfam02570 675635007337 precorrin-3B synthase; Region: CobG; TIGR02435 675635007338 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 675635007339 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 675635007340 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 675635007341 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 675635007342 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 675635007343 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 675635007344 active site 675635007345 dimer interface [polypeptide binding]; other site 675635007346 metal binding site [ion binding]; metal-binding site 675635007347 phenylhydantoinase; Validated; Region: PRK08323 675635007348 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635007349 active site 675635007350 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635007351 TM-ABC transporter signature motif; other site 675635007352 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635007353 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635007354 Walker A/P-loop; other site 675635007355 ATP binding site [chemical binding]; other site 675635007356 Q-loop/lid; other site 675635007357 ABC transporter signature motif; other site 675635007358 Walker B; other site 675635007359 D-loop; other site 675635007360 H-loop/switch region; other site 675635007361 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 675635007362 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635007363 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635007364 ligand binding site [chemical binding]; other site 675635007365 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635007366 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635007367 DNA-binding site [nucleotide binding]; DNA binding site 675635007368 FCD domain; Region: FCD; cl11656 675635007369 phenylhydantoinase; Validated; Region: PRK08323 675635007370 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635007371 active site 675635007372 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635007373 Amidase; Region: Amidase; cl11426 675635007374 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 675635007375 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635007376 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635007377 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 675635007378 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635007379 carboxyltransferase (CT) interaction site; other site 675635007380 biotinylation site [posttranslational modification]; other site 675635007381 oxaloacetate decarboxylase; Provisional; Region: PRK14041 675635007382 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 675635007383 active site 675635007384 catalytic residues [active] 675635007385 metal binding site [ion binding]; metal-binding site 675635007386 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 675635007387 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 675635007388 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 675635007389 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 675635007390 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 675635007391 metal binding site [ion binding]; metal-binding site 675635007392 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 675635007393 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 675635007394 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 675635007395 dimer interface [polypeptide binding]; other site 675635007396 putative PBP binding regions; other site 675635007397 ABC-ATPase subunit interface; other site 675635007398 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 675635007399 Helix-turn-helix domains; Region: HTH; cl00088 675635007400 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 675635007401 FeoA domain; Region: FeoA; cl00838 675635007402 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 675635007403 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 675635007404 putative dimer interface [polypeptide binding]; other site 675635007405 [2Fe-2S] cluster binding site [ion binding]; other site 675635007406 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 675635007407 putative dimer interface [polypeptide binding]; other site 675635007408 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 675635007409 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 675635007410 SLBB domain; Region: SLBB; pfam10531 675635007411 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 675635007412 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 675635007413 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635007414 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 675635007415 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 675635007416 [4Fe-4S] binding site [ion binding]; other site 675635007417 molybdopterin cofactor binding site; other site 675635007418 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 675635007419 molybdopterin cofactor binding site; other site 675635007420 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 675635007421 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635007422 Helix-turn-helix domains; Region: HTH; cl00088 675635007423 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635007424 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 675635007425 putative ligand binding site [chemical binding]; other site 675635007426 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 675635007427 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 675635007428 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 675635007429 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 675635007430 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 675635007431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635007432 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635007433 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635007434 DNA binding residues [nucleotide binding] 675635007435 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 675635007436 active site 675635007437 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 675635007438 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 675635007439 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 675635007440 putative active site [active] 675635007441 putative substrate binding site [chemical binding]; other site 675635007442 ATP binding site [chemical binding]; other site 675635007443 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 675635007444 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 675635007445 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 675635007446 trimer interface [polypeptide binding]; other site 675635007447 active site 675635007448 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 675635007449 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 675635007450 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 675635007451 generic binding surface II; other site 675635007452 ssDNA binding site; other site 675635007453 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 675635007454 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 675635007455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007456 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 675635007457 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 675635007458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007459 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 675635007460 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 675635007461 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 675635007462 TRAM domain; Region: TRAM; cl01282 675635007463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 675635007464 Uncharacterized conserved protein [Function unknown]; Region: COG3777 675635007465 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635007466 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635007467 active site 2 [active] 675635007468 active site 1 [active] 675635007469 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 675635007470 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 675635007471 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 675635007472 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 675635007473 RNA binding site [nucleotide binding]; other site 675635007474 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 675635007475 DEAD-like helicases superfamily; Region: DEXDc; smart00487 675635007476 ATP binding site [chemical binding]; other site 675635007477 Mg++ binding site [ion binding]; other site 675635007478 motif III; other site 675635007479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635007480 nucleotide binding region [chemical binding]; other site 675635007481 ATP-binding site [chemical binding]; other site 675635007482 DbpA RNA binding domain; Region: DbpA; pfam03880 675635007483 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 675635007484 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 675635007485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635007486 putative substrate translocation pore; other site 675635007487 Dehydratase family; Region: ILVD_EDD; cl00340 675635007488 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 675635007489 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635007490 Helix-turn-helix domains; Region: HTH; cl00088 675635007491 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 675635007492 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635007493 tetramer interface [polypeptide binding]; other site 675635007494 TPP-binding site [chemical binding]; other site 675635007495 heterodimer interface [polypeptide binding]; other site 675635007496 phosphorylation loop region [posttranslational modification] 675635007497 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635007498 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 675635007499 alpha subunit interface [polypeptide binding]; other site 675635007500 TPP binding site [chemical binding]; other site 675635007501 heterodimer interface [polypeptide binding]; other site 675635007502 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635007503 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635007504 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 675635007505 E3 interaction surface; other site 675635007506 lipoyl attachment site [posttranslational modification]; other site 675635007507 e3 binding domain; Region: E3_binding; pfam02817 675635007508 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 675635007509 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635007510 Transposase domain (DUF772); Region: DUF772; cl15789 675635007511 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635007512 Sodium:solute symporter family; Region: SSF; cl00456 675635007513 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 675635007514 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635007515 active site 675635007516 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635007517 Helix-turn-helix domains; Region: HTH; cl00088 675635007518 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635007519 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 675635007520 Uncharacterized conserved protein [Function unknown]; Region: COG3535 675635007521 Protein of unknown function (DUF917); Region: DUF917; pfam06032 675635007522 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 675635007523 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635007524 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 675635007525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007526 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635007527 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635007528 Transposase domain (DUF772); Region: DUF772; cl15789 675635007529 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635007530 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 675635007531 Helix-turn-helix domains; Region: HTH; cl00088 675635007532 Flavin Reductases; Region: FlaRed; cl00801 675635007533 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635007534 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 675635007535 active site 675635007536 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 675635007537 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635007538 metal binding site [ion binding]; metal-binding site 675635007539 substrate binding pocket [chemical binding]; other site 675635007540 Muconolactone delta-isomerase; Region: MIase; cl01992 675635007541 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635007542 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635007543 active site 675635007544 metal binding site [ion binding]; metal-binding site 675635007545 Predicted esterase [General function prediction only]; Region: COG0400 675635007546 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 675635007547 active site 675635007548 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 675635007549 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 675635007550 dimer interface [polypeptide binding]; other site 675635007551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635007552 catalytic residue [active] 675635007553 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 675635007554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635007555 S-adenosylmethionine binding site [chemical binding]; other site 675635007556 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 675635007557 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635007558 classical (c) SDRs; Region: SDR_c; cd05233 675635007559 NAD(P) binding site [chemical binding]; other site 675635007560 active site 675635007561 Epoxide hydrolase N terminus; Region: EHN; pfam06441 675635007562 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635007563 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 675635007564 intersubunit interface [polypeptide binding]; other site 675635007565 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 675635007566 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 675635007567 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635007568 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 675635007569 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635007570 Walker A/P-loop; other site 675635007571 ATP binding site [chemical binding]; other site 675635007572 Q-loop/lid; other site 675635007573 ABC transporter signature motif; other site 675635007574 Walker B; other site 675635007575 D-loop; other site 675635007576 H-loop/switch region; other site 675635007577 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 675635007578 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 675635007579 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 675635007580 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 675635007581 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 675635007582 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 675635007583 substrate binding site [chemical binding]; other site 675635007584 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 675635007585 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 675635007586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007587 NAD(P) binding site [chemical binding]; other site 675635007588 active site 675635007589 Helix-turn-helix domains; Region: HTH; cl00088 675635007590 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 675635007591 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635007592 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 675635007593 Walker A/P-loop; other site 675635007594 ATP binding site [chemical binding]; other site 675635007595 Q-loop/lid; other site 675635007596 ABC transporter signature motif; other site 675635007597 Walker B; other site 675635007598 D-loop; other site 675635007599 H-loop/switch region; other site 675635007600 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 675635007601 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635007602 Walker A/P-loop; other site 675635007603 ATP binding site [chemical binding]; other site 675635007604 Q-loop/lid; other site 675635007605 ABC transporter signature motif; other site 675635007606 Walker B; other site 675635007607 D-loop; other site 675635007608 H-loop/switch region; other site 675635007609 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 675635007610 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 675635007611 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 675635007612 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 675635007613 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 675635007614 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 675635007615 heterodimer interface [polypeptide binding]; other site 675635007616 substrate interaction site [chemical binding]; other site 675635007617 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 675635007618 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 675635007619 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 675635007620 active site 675635007621 substrate binding site [chemical binding]; other site 675635007622 coenzyme B12 binding site [chemical binding]; other site 675635007623 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 675635007624 B12 binding site [chemical binding]; other site 675635007625 cobalt ligand [ion binding]; other site 675635007626 membrane ATPase/protein kinase; Provisional; Region: PRK09435 675635007627 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 675635007628 Walker A; other site 675635007629 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 675635007630 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 675635007631 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 675635007632 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 675635007633 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635007634 Uncharacterized conserved protein [Function unknown]; Region: COG5361 675635007635 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 675635007636 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 675635007637 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635007638 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635007639 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 675635007640 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635007641 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 675635007642 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635007643 Protein of unknown function (DUF742); Region: DUF742; pfam05331 675635007644 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635007645 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635007646 active site 675635007647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635007648 putative Zn2+ binding site [ion binding]; other site 675635007649 putative DNA binding site [nucleotide binding]; other site 675635007650 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635007651 ATP binding site [chemical binding]; other site 675635007652 putative Mg++ binding site [ion binding]; other site 675635007653 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 675635007654 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635007655 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 675635007656 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 675635007657 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 675635007658 active site 675635007659 DNA binding site [nucleotide binding] 675635007660 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 675635007661 DNA binding site [nucleotide binding] 675635007662 Histidine kinase; Region: His_kinase; pfam06580 675635007663 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 675635007664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635007665 motif II; other site 675635007666 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 675635007667 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 675635007668 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 675635007669 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 675635007670 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 675635007671 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635007672 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635007673 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635007674 DNA binding residues [nucleotide binding] 675635007675 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 675635007676 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635007677 Family description; Region: UvrD_C_2; cl15862 675635007678 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 675635007679 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 675635007680 catalytic triad [active] 675635007681 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 675635007682 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635007683 ATP binding site [chemical binding]; other site 675635007684 putative Mg++ binding site [ion binding]; other site 675635007685 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635007686 nucleotide binding region [chemical binding]; other site 675635007687 ATP-binding site [chemical binding]; other site 675635007688 RQC domain; Region: RQC; cl09632 675635007689 HRDC domain; Region: HRDC; cl02578 675635007690 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 675635007691 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635007692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635007693 Bacterial transcriptional activator domain; Region: BTAD; smart01043 675635007694 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635007695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635007696 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 675635007697 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 675635007698 hypothetical protein; Validated; Region: PRK07586 675635007699 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635007700 PYR/PP interface [polypeptide binding]; other site 675635007701 dimer interface [polypeptide binding]; other site 675635007702 TPP binding site [chemical binding]; other site 675635007703 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635007704 TPP-binding site [chemical binding]; other site 675635007705 OsmC-like protein; Region: OsmC; cl00767 675635007706 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 675635007707 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 675635007708 phosphopeptide binding site; other site 675635007709 Bifunctional nuclease; Region: DNase-RNase; cl00553 675635007710 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635007711 DNA binding residues [nucleotide binding] 675635007712 glycine dehydrogenase; Provisional; Region: PRK05367 675635007713 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635007714 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635007715 catalytic residue [active] 675635007716 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635007717 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635007718 catalytic residue [active] 675635007719 Domain of unknown function DUF21; Region: DUF21; pfam01595 675635007720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 675635007721 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 675635007722 Domain of unknown function DUF21; Region: DUF21; pfam01595 675635007723 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 675635007724 Transporter associated domain; Region: CorC_HlyC; cl08393 675635007725 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 675635007726 pantothenate kinase; Provisional; Region: PRK05439 675635007727 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 675635007728 ATP-binding site [chemical binding]; other site 675635007729 CoA-binding site [chemical binding]; other site 675635007730 Mg2+-binding site [ion binding]; other site 675635007731 Helix-turn-helix domains; Region: HTH; cl00088 675635007732 Domain of unknown function (DUF427); Region: DUF427; cl00998 675635007733 Domain of unknown function (DUF427); Region: DUF427; cl00998 675635007734 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635007735 active site 675635007736 ATP binding site [chemical binding]; other site 675635007737 substrate binding site [chemical binding]; other site 675635007738 activation loop (A-loop); other site 675635007739 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 675635007740 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 675635007741 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635007742 Helix-turn-helix domains; Region: HTH; cl00088 675635007743 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 675635007744 putative FMN binding site [chemical binding]; other site 675635007745 hypothetical protein; Provisional; Region: PRK08317 675635007746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007747 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635007748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635007749 active site 675635007750 phosphorylation site [posttranslational modification] 675635007751 intermolecular recognition site; other site 675635007752 dimerization interface [polypeptide binding]; other site 675635007753 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635007754 DNA binding residues [nucleotide binding] 675635007755 dimerization interface [polypeptide binding]; other site 675635007756 Histidine kinase; Region: HisKA_3; pfam07730 675635007757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635007758 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635007759 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635007760 allophanate hydrolase; Provisional; Region: PRK08186 675635007761 Amidase; Region: Amidase; cl11426 675635007762 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635007763 Isochorismatase family; Region: Isochorismatase; pfam00857 675635007764 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 675635007765 catalytic triad [active] 675635007766 conserved cis-peptide bond; other site 675635007767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635007768 DNA-binding site [nucleotide binding]; DNA binding site 675635007769 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 675635007770 FCD domain; Region: FCD; cl11656 675635007771 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 675635007772 ring-opening amidohydrolases; Region: amido_AtzD_TrzD; TIGR02714 675635007773 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635007774 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635007775 ligand binding site [chemical binding]; other site 675635007776 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635007777 TM-ABC transporter signature motif; other site 675635007778 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635007779 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635007780 Walker A/P-loop; other site 675635007781 ATP binding site [chemical binding]; other site 675635007782 Q-loop/lid; other site 675635007783 ABC transporter signature motif; other site 675635007784 Walker B; other site 675635007785 D-loop; other site 675635007786 H-loop/switch region; other site 675635007787 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 675635007788 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 675635007789 oxidase reductase; Provisional; Region: PTZ00273 675635007790 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 675635007791 Cupin domain; Region: Cupin_2; cl09118 675635007792 hypothetical protein; Provisional; Region: PRK07538 675635007793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007794 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635007795 FAD binding domain; Region: FAD_binding_4; pfam01565 675635007796 Berberine and berberine like; Region: BBE; pfam08031 675635007797 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 675635007798 Ferredoxin [Energy production and conversion]; Region: COG1146 675635007799 4Fe-4S binding domain; Region: Fer4; cl02805 675635007800 Predicted transcriptional regulator [Transcription]; Region: COG2345 675635007801 Helix-turn-helix domains; Region: HTH; cl00088 675635007802 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635007803 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635007804 DNA binding residues [nucleotide binding] 675635007805 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 675635007806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635007807 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 675635007808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635007809 dimer interface [polypeptide binding]; other site 675635007810 conserved gate region; other site 675635007811 putative PBP binding loops; other site 675635007812 ABC-ATPase subunit interface; other site 675635007813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635007814 dimer interface [polypeptide binding]; other site 675635007815 conserved gate region; other site 675635007816 putative PBP binding loops; other site 675635007817 ABC-ATPase subunit interface; other site 675635007818 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 675635007819 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 675635007820 Walker A/P-loop; other site 675635007821 ATP binding site [chemical binding]; other site 675635007822 Q-loop/lid; other site 675635007823 ABC transporter signature motif; other site 675635007824 Walker B; other site 675635007825 D-loop; other site 675635007826 H-loop/switch region; other site 675635007827 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635007828 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635007829 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635007830 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635007831 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635007832 Helix-turn-helix domains; Region: HTH; cl00088 675635007833 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635007834 lipid-transfer protein; Provisional; Region: PRK07855 675635007835 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635007836 active site 675635007837 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635007838 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635007839 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635007840 enoyl-CoA hydratase; Provisional; Region: PRK08252 675635007841 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635007842 substrate binding site [chemical binding]; other site 675635007843 oxyanion hole (OAH) forming residues; other site 675635007844 trimer interface [polypeptide binding]; other site 675635007845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007846 NAD(P) binding site [chemical binding]; other site 675635007847 active site 675635007848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635007849 Helix-turn-helix domains; Region: HTH; cl00088 675635007850 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635007851 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635007852 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 675635007853 Strictosidine synthase; Region: Str_synth; pfam03088 675635007854 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635007855 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635007856 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635007857 substrate binding pocket [chemical binding]; other site 675635007858 catalytic triad [active] 675635007859 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635007860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007861 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635007862 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635007863 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635007864 classical (c) SDRs; Region: SDR_c; cd05233 675635007865 NAD(P) binding site [chemical binding]; other site 675635007866 active site 675635007867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635007868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635007869 Helix-turn-helix domains; Region: HTH; cl00088 675635007870 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 675635007871 Helix-turn-helix domains; Region: HTH; cl00088 675635007872 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635007873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635007874 DNA-binding site [nucleotide binding]; DNA binding site 675635007875 FCD domain; Region: FCD; cl11656 675635007876 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635007877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007878 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635007879 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635007880 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635007881 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 675635007882 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635007883 Dehydratase family; Region: ILVD_EDD; cl00340 675635007884 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 675635007885 gating phenylalanine in ion channel; other site 675635007886 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635007887 dimerization interface [polypeptide binding]; other site 675635007888 putative DNA binding site [nucleotide binding]; other site 675635007889 putative Zn2+ binding site [ion binding]; other site 675635007890 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 675635007891 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635007892 putative ligand binding site [chemical binding]; other site 675635007893 Amidase; Region: Amidase; cl11426 675635007894 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635007895 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 675635007896 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635007897 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 675635007898 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 675635007899 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 675635007900 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635007901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007902 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635007903 Amidase; Region: Amidase; cl11426 675635007904 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 675635007905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635007906 Walker A motif; other site 675635007907 ATP binding site [chemical binding]; other site 675635007908 Walker B motif; other site 675635007909 arginine finger; other site 675635007910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635007911 Integrase core domain; Region: rve; cl01316 675635007912 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 675635007913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007914 Helix-turn-helix domains; Region: HTH; cl00088 675635007915 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635007916 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635007917 Helix-turn-helix domains; Region: HTH; cl00088 675635007918 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 675635007919 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 675635007920 Protein of unknown function, DUF488; Region: DUF488; cl01246 675635007921 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635007922 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635007923 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635007924 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635007925 Walker A/P-loop; other site 675635007926 ATP binding site [chemical binding]; other site 675635007927 Q-loop/lid; other site 675635007928 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635007929 ABC transporter signature motif; other site 675635007930 Walker B; other site 675635007931 D-loop; other site 675635007932 H-loop/switch region; other site 675635007933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635007934 Walker A/P-loop; other site 675635007935 ATP binding site [chemical binding]; other site 675635007936 Q-loop/lid; other site 675635007937 ABC transporter signature motif; other site 675635007938 Walker B; other site 675635007939 D-loop; other site 675635007940 H-loop/switch region; other site 675635007941 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 675635007942 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635007943 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635007944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635007945 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 675635007946 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 675635007947 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 675635007948 heme binding site [chemical binding]; other site 675635007949 ferroxidase pore; other site 675635007950 ferroxidase diiron center [ion binding]; other site 675635007951 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 675635007952 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 675635007953 active site 675635007954 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 675635007955 nucleotide binding site [chemical binding]; other site 675635007956 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 675635007957 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 675635007958 active site 675635007959 catalytic site [active] 675635007960 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 675635007961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635007962 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 675635007963 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 675635007964 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 675635007965 Ligand binding site; other site 675635007966 Putative Catalytic site; other site 675635007967 DXD motif; other site 675635007968 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 675635007969 putative active site [active] 675635007970 catalytic triad [active] 675635007971 putative dimer interface [polypeptide binding]; other site 675635007972 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635007973 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635007974 Amidohydrolase family; Region: Amidohydro_3; pfam07969 675635007975 active site 675635007976 PspC domain; Region: PspC; cl00864 675635007977 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635007978 oxyanion hole [active] 675635007979 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 675635007980 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 675635007981 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 675635007982 active site 675635007983 5'-3' exonuclease; Region: 53EXOc; smart00475 675635007984 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 675635007985 active site 675635007986 metal binding site 1 [ion binding]; metal-binding site 675635007987 putative 5' ssDNA interaction site; other site 675635007988 metal binding site 3; metal-binding site 675635007989 metal binding site 2 [ion binding]; metal-binding site 675635007990 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 675635007991 putative DNA binding site [nucleotide binding]; other site 675635007992 putative metal binding site [ion binding]; other site 675635007993 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 675635007994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635007995 ATP binding site [chemical binding]; other site 675635007996 putative Mg++ binding site [ion binding]; other site 675635007997 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635007998 nucleotide binding region [chemical binding]; other site 675635007999 ATP-binding site [chemical binding]; other site 675635008000 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 675635008001 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 675635008002 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 675635008003 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 675635008004 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635008005 WYL domain; Region: WYL; cl14852 675635008006 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635008007 WYL domain; Region: WYL; cl14852 675635008008 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 675635008009 Pup-ligase protein; Region: Pup_ligase; cl15463 675635008010 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 675635008011 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635008012 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 675635008013 4Fe-4S binding domain; Region: Fer4; cl02805 675635008014 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635008015 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 675635008016 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 675635008017 putative dimer interface [polypeptide binding]; other site 675635008018 [2Fe-2S] cluster binding site [ion binding]; other site 675635008019 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 675635008020 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 675635008021 SLBB domain; Region: SLBB; pfam10531 675635008022 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 675635008023 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 675635008024 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635008025 molybdopterin cofactor binding site; other site 675635008026 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 675635008027 molybdopterin cofactor binding site; other site 675635008028 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635008029 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635008030 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 675635008031 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635008032 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635008033 active site 675635008034 metal binding site [ion binding]; metal-binding site 675635008035 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635008036 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635008037 active site 675635008038 metal binding site [ion binding]; metal-binding site 675635008039 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 675635008040 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 675635008041 active site 675635008042 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 675635008043 active site 675635008044 Pup-like protein; Region: Pup; cl05289 675635008045 Pup-ligase protein; Region: Pup_ligase; cl15463 675635008046 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635008047 nudix motif; other site 675635008048 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 675635008049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008050 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635008051 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635008052 Helix-turn-helix domains; Region: HTH; cl00088 675635008053 YceI-like domain; Region: YceI; cl01001 675635008054 classical (c) SDRs; Region: SDR_c; cd05233 675635008055 NAD(P) binding site [chemical binding]; other site 675635008056 active site 675635008057 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635008058 Helix-turn-helix domains; Region: HTH; cl00088 675635008059 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635008060 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635008061 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635008062 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 675635008063 dimer interface [polypeptide binding]; other site 675635008064 ligand binding site [chemical binding]; other site 675635008065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635008066 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635008067 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635008068 DNA binding residues [nucleotide binding] 675635008069 dimerization interface [polypeptide binding]; other site 675635008070 YceI-like domain; Region: YceI; cl01001 675635008071 Autophagy protein 16 (ATG16); Region: ATG16; pfam08614 675635008072 proteasome ATPase; Region: pup_AAA; TIGR03689 675635008073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635008074 Walker A motif; other site 675635008075 ATP binding site [chemical binding]; other site 675635008076 Walker B motif; other site 675635008077 arginine finger; other site 675635008078 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 675635008079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635008080 S-adenosylmethionine binding site [chemical binding]; other site 675635008081 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 675635008082 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 675635008083 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 675635008084 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 675635008085 ATP phosphoribosyltransferase; Region: HisG; cl15266 675635008086 HisG, C-terminal domain; Region: HisG_C; cl06867 675635008087 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 675635008088 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 675635008089 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635008090 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 675635008091 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 675635008092 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 675635008093 substrate binding pocket [chemical binding]; other site 675635008094 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 675635008095 B12 binding site [chemical binding]; other site 675635008096 cobalt ligand [ion binding]; other site 675635008097 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 675635008098 PAC2 family; Region: PAC2; cl00847 675635008099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635008100 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 675635008101 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635008102 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 675635008103 active site 675635008104 HIGH motif; other site 675635008105 nucleotide binding site [chemical binding]; other site 675635008106 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635008107 active site 675635008108 KMSKS motif; other site 675635008109 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 675635008110 putative tRNA binding surface [nucleotide binding]; other site 675635008111 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 675635008112 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 675635008113 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 675635008114 metal ion-dependent adhesion site (MIDAS); other site 675635008115 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 675635008116 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635008117 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635008118 Peptidase family M48; Region: Peptidase_M48; cl12018 675635008119 Helix-turn-helix domains; Region: HTH; cl00088 675635008120 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 675635008121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635008122 putative substrate translocation pore; other site 675635008123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635008124 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635008125 Uncharacterized conserved protein [Function unknown]; Region: COG3349 675635008126 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 675635008127 active site 675635008128 DNA binding site [nucleotide binding] 675635008129 catalytic site [active] 675635008130 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 675635008131 active site 675635008132 catalytic triad [active] 675635008133 oxyanion hole [active] 675635008134 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 675635008135 spermidine synthase; Provisional; Region: PRK03612 675635008136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635008137 S-adenosylmethionine binding site [chemical binding]; other site 675635008138 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 675635008139 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 675635008140 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 675635008141 catalytic residue [active] 675635008142 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635008143 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635008144 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635008145 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635008146 active site 675635008147 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635008148 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 675635008149 tetramerization interface [polypeptide binding]; other site 675635008150 NAD(P) binding site [chemical binding]; other site 675635008151 catalytic residues [active] 675635008152 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 675635008153 PDGLE domain; Region: PDGLE; cl07986 675635008154 Cobalt transport protein; Region: CbiQ; cl00463 675635008155 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 675635008156 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 675635008157 Walker A/P-loop; other site 675635008158 ATP binding site [chemical binding]; other site 675635008159 Q-loop/lid; other site 675635008160 ABC transporter signature motif; other site 675635008161 Walker B; other site 675635008162 D-loop; other site 675635008163 H-loop/switch region; other site 675635008164 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 675635008165 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 675635008166 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 675635008167 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 675635008168 GAF domain; Region: GAF; cl15785 675635008169 GAF domain; Region: GAF_2; pfam13185 675635008170 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 675635008171 Helix-turn-helix domains; Region: HTH; cl00088 675635008172 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635008173 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635008174 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635008175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008176 NAD(P) binding site [chemical binding]; other site 675635008177 active site 675635008178 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635008179 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635008180 AMP-binding enzyme; Region: AMP-binding; cl15778 675635008181 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635008182 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635008183 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635008184 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 675635008185 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 675635008186 putative active site [active] 675635008187 putative substrate binding site [chemical binding]; other site 675635008188 ATP binding site [chemical binding]; other site 675635008189 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635008190 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635008191 active site 675635008192 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635008193 active site 675635008194 DNA binding site [nucleotide binding] 675635008195 Int/Topo IB signature motif; other site 675635008196 ferrochelatase; Reviewed; Region: hemH; PRK00035 675635008197 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 675635008198 C-terminal domain interface [polypeptide binding]; other site 675635008199 active site 675635008200 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 675635008201 active site 675635008202 N-terminal domain interface [polypeptide binding]; other site 675635008203 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 675635008204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008205 NAD(P) binding site [chemical binding]; other site 675635008206 active site 675635008207 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 675635008208 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 675635008209 NAD(P) binding site [chemical binding]; other site 675635008210 homotetramer interface [polypeptide binding]; other site 675635008211 homodimer interface [polypeptide binding]; other site 675635008212 active site 675635008213 hypothetical protein; Provisional; Region: PRK13685 675635008214 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 675635008215 metal ion-dependent adhesion site (MIDAS); other site 675635008216 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 675635008217 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 675635008218 MoxR-like ATPases [General function prediction only]; Region: COG0714 675635008219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635008220 Walker A motif; other site 675635008221 ATP binding site [chemical binding]; other site 675635008222 Walker B motif; other site 675635008223 arginine finger; other site 675635008224 NlpC/P60 family; Region: NLPC_P60; cl11438 675635008225 aconitate hydratase; Validated; Region: PRK09277 675635008226 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 675635008227 substrate binding site [chemical binding]; other site 675635008228 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 675635008229 ligand binding site [chemical binding]; other site 675635008230 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 675635008231 substrate binding site [chemical binding]; other site 675635008232 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 675635008233 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 675635008234 Cupin domain; Region: Cupin_2; cl09118 675635008235 probable methyltransferase; Region: TIGR03438 675635008236 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 675635008237 TIGR03442 family protein; Region: TIGR03442 675635008238 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 675635008239 putative active site [active] 675635008240 putative dimer interface [polypeptide binding]; other site 675635008241 TIGR03440 family protein; Region: unchr_TIGR03440 675635008242 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 675635008243 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 675635008244 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635008245 Helix-turn-helix domains; Region: HTH; cl00088 675635008246 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635008247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635008248 putative substrate translocation pore; other site 675635008249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635008250 substrate binding site [chemical binding]; other site 675635008251 oxyanion hole (OAH) forming residues; other site 675635008252 trimer interface [polypeptide binding]; other site 675635008253 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 675635008254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635008255 Walker A/P-loop; other site 675635008256 ATP binding site [chemical binding]; other site 675635008257 Q-loop/lid; other site 675635008258 ABC transporter signature motif; other site 675635008259 Walker B; other site 675635008260 D-loop; other site 675635008261 H-loop/switch region; other site 675635008262 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 675635008263 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 675635008264 classical (c) SDRs; Region: SDR_c; cd05233 675635008265 NAD(P) binding site [chemical binding]; other site 675635008266 active site 675635008267 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635008268 Ligand Binding Site [chemical binding]; other site 675635008269 cyclase homology domain; Region: CHD; cd07302 675635008270 nucleotidyl binding site; other site 675635008271 metal binding site [ion binding]; metal-binding site 675635008272 dimer interface [polypeptide binding]; other site 675635008273 Domain of unknown function DUF59; Region: DUF59; cl00941 675635008274 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 675635008275 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 675635008276 trimerization site [polypeptide binding]; other site 675635008277 active site 675635008278 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 675635008279 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 675635008280 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635008281 catalytic residue [active] 675635008282 FeS assembly ATPase SufC; Region: sufC; TIGR01978 675635008283 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 675635008284 Walker A/P-loop; other site 675635008285 ATP binding site [chemical binding]; other site 675635008286 Q-loop/lid; other site 675635008287 ABC transporter signature motif; other site 675635008288 Walker B; other site 675635008289 D-loop; other site 675635008290 H-loop/switch region; other site 675635008291 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 675635008292 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 675635008293 FeS assembly protein SufB; Region: sufB; TIGR01980 675635008294 Predicted transcriptional regulator [Transcription]; Region: COG2345 675635008295 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 675635008296 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 675635008297 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 675635008298 Walker A/P-loop; other site 675635008299 ATP binding site [chemical binding]; other site 675635008300 Q-loop/lid; other site 675635008301 ABC transporter signature motif; other site 675635008302 Walker B; other site 675635008303 D-loop; other site 675635008304 H-loop/switch region; other site 675635008305 ABC-2 type transporter; Region: ABC2_membrane; cl11417 675635008306 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 675635008307 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 675635008308 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 675635008309 NADP binding site [chemical binding]; other site 675635008310 dimer interface [polypeptide binding]; other site 675635008311 UbiA prenyltransferase family; Region: UbiA; cl00337 675635008312 transketolase; Reviewed; Region: PRK05899 675635008313 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 675635008314 TPP-binding site [chemical binding]; other site 675635008315 dimer interface [polypeptide binding]; other site 675635008316 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 675635008317 PYR/PP interface [polypeptide binding]; other site 675635008318 dimer interface [polypeptide binding]; other site 675635008319 TPP binding site [chemical binding]; other site 675635008320 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635008321 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 675635008322 putative active site [active] 675635008323 transaldolase; Provisional; Region: PRK03903 675635008324 catalytic residue [active] 675635008325 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 675635008326 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 675635008327 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 675635008328 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 675635008329 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 675635008330 opcA protein; Region: OpcA; TIGR00534 675635008331 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 675635008332 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 675635008333 putative active site [active] 675635008334 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 675635008335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008336 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635008337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008338 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 675635008339 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 675635008340 substrate binding site [chemical binding]; other site 675635008341 dimer interface [polypeptide binding]; other site 675635008342 catalytic triad [active] 675635008343 Phosphoglycerate kinase; Region: PGK; pfam00162 675635008344 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 675635008345 substrate binding site [chemical binding]; other site 675635008346 hinge regions; other site 675635008347 ADP binding site [chemical binding]; other site 675635008348 catalytic site [active] 675635008349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008350 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 675635008351 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 675635008352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 675635008353 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 675635008354 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 675635008355 putative substrate binding pocket [chemical binding]; other site 675635008356 dimer interface [polypeptide binding]; other site 675635008357 phosphate binding site [ion binding]; other site 675635008358 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 675635008359 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 675635008360 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 675635008361 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 675635008362 GIY-YIG motif/motif A; other site 675635008363 active site 675635008364 catalytic site [active] 675635008365 putative DNA binding site [nucleotide binding]; other site 675635008366 metal binding site [ion binding]; metal-binding site 675635008367 UvrB/uvrC motif; Region: UVR; pfam02151 675635008368 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 675635008369 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 675635008370 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 675635008371 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 675635008372 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 675635008373 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635008374 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 675635008375 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 675635008376 homopentamer interface [polypeptide binding]; other site 675635008377 active site 675635008378 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 675635008379 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 675635008380 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 675635008381 dimerization interface [polypeptide binding]; other site 675635008382 active site 675635008383 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 675635008384 Lumazine binding domain; Region: Lum_binding; pfam00677 675635008385 Lumazine binding domain; Region: Lum_binding; pfam00677 675635008386 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 675635008387 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 675635008388 catalytic motif [active] 675635008389 Zn binding site [ion binding]; other site 675635008390 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 675635008391 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 675635008392 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 675635008393 substrate binding site [chemical binding]; other site 675635008394 hexamer interface [polypeptide binding]; other site 675635008395 metal binding site [ion binding]; metal-binding site 675635008396 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 675635008397 putative RNA binding site [nucleotide binding]; other site 675635008398 16S rRNA methyltransferase B; Provisional; Region: PRK14902 675635008399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 675635008400 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 675635008401 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 675635008402 putative active site [active] 675635008403 substrate binding site [chemical binding]; other site 675635008404 putative cosubstrate binding site; other site 675635008405 catalytic site [active] 675635008406 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 675635008407 substrate binding site [chemical binding]; other site 675635008408 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 675635008409 active site 675635008410 catalytic residues [active] 675635008411 metal binding site [ion binding]; metal-binding site 675635008412 primosome assembly protein PriA; Provisional; Region: PRK14873 675635008413 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 675635008414 Cupin domain; Region: Cupin_2; cl09118 675635008415 S-adenosylmethionine synthetase; Validated; Region: PRK05250 675635008416 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 675635008417 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 675635008418 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 675635008419 Bacterial SH3 domain; Region: SH3_3; cl02551 675635008420 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 675635008421 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 675635008422 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 675635008423 Helix-turn-helix domains; Region: HTH; cl00088 675635008424 Ferritin-like domain; Region: Ferritin; pfam00210 675635008425 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 675635008426 dimerization interface [polypeptide binding]; other site 675635008427 DPS ferroxidase diiron center [ion binding]; other site 675635008428 ion pore; other site 675635008429 Protease prsW family; Region: PrsW-protease; cl15823 675635008430 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 675635008431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008432 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635008433 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 675635008434 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 675635008435 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 675635008436 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635008437 ligand binding site [chemical binding]; other site 675635008438 flexible hinge region; other site 675635008439 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 675635008440 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635008441 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 675635008442 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 675635008443 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 675635008444 NAD binding site [chemical binding]; other site 675635008445 catalytic Zn binding site [ion binding]; other site 675635008446 structural Zn binding site [ion binding]; other site 675635008447 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 675635008448 BON domain; Region: BON; cl02771 675635008449 BON domain; Region: BON; cl02771 675635008450 transketolase; Reviewed; Region: PRK05899 675635008451 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 675635008452 TPP-binding site [chemical binding]; other site 675635008453 dimer interface [polypeptide binding]; other site 675635008454 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 675635008455 PYR/PP interface [polypeptide binding]; other site 675635008456 dimer interface [polypeptide binding]; other site 675635008457 TPP binding site [chemical binding]; other site 675635008458 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635008459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635008460 Walker A motif; other site 675635008461 ATP binding site [chemical binding]; other site 675635008462 Walker B motif; other site 675635008463 arginine finger; other site 675635008464 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 675635008465 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635008466 active site 675635008467 DNA binding site [nucleotide binding] 675635008468 Int/Topo IB signature motif; other site 675635008469 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 675635008470 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635008471 active site 675635008472 DNA binding site [nucleotide binding] 675635008473 Int/Topo IB signature motif; other site 675635008474 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 675635008475 Mechanosensitive ion channel; Region: MS_channel; pfam00924 675635008476 Protein of unknown function (DUF461); Region: DUF461; cl01071 675635008477 pyruvate dehydrogenase; Provisional; Region: PRK09124 675635008478 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 675635008479 PYR/PP interface [polypeptide binding]; other site 675635008480 tetramer interface [polypeptide binding]; other site 675635008481 dimer interface [polypeptide binding]; other site 675635008482 TPP binding site [chemical binding]; other site 675635008483 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 675635008484 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 675635008485 TPP-binding site [chemical binding]; other site 675635008486 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 675635008487 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635008488 active site 675635008489 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 675635008490 Erythromycin esterase; Region: Erythro_esteras; pfam05139 675635008491 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 675635008492 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635008493 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635008494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635008495 DNA binding residues [nucleotide binding] 675635008496 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 675635008497 catalytic residues [active] 675635008498 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 675635008499 Clp amino terminal domain; Region: Clp_N; pfam02861 675635008500 Clp amino terminal domain; Region: Clp_N; pfam02861 675635008501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635008502 Walker A motif; other site 675635008503 ATP binding site [chemical binding]; other site 675635008504 Walker B motif; other site 675635008505 arginine finger; other site 675635008506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635008507 Walker A motif; other site 675635008508 ATP binding site [chemical binding]; other site 675635008509 Walker B motif; other site 675635008510 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 675635008511 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 675635008512 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 675635008513 HSP70 interaction site [polypeptide binding]; other site 675635008514 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 675635008515 substrate binding site [polypeptide binding]; other site 675635008516 dimer interface [polypeptide binding]; other site 675635008517 heat shock protein GrpE; Provisional; Region: PRK14140 675635008518 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 675635008519 dimer interface [polypeptide binding]; other site 675635008520 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 675635008521 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 675635008522 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 675635008523 putative dimer interface [polypeptide binding]; other site 675635008524 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635008525 anti sigma factor interaction site; other site 675635008526 regulatory phosphorylation site [posttranslational modification]; other site 675635008527 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 675635008528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635008529 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 675635008530 Transcription factor WhiB; Region: Whib; pfam02467 675635008531 ParB-like nuclease domain; Region: ParBc; cl02129 675635008532 BON domain; Region: BON; cl02771 675635008533 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 675635008534 BON domain; Region: BON; cl02771 675635008535 BON domain; Region: BON; cl02771 675635008536 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 675635008537 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 675635008538 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 675635008539 Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503 675635008540 Protein required for attachment to host cells; Region: Host_attach; cl02398 675635008541 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635008542 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 675635008543 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 675635008544 intracellular protease, PfpI family; Region: PfpI; TIGR01382 675635008545 proposed catalytic triad [active] 675635008546 conserved cys residue [active] 675635008547 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 675635008548 Helix-turn-helix domains; Region: HTH; cl00088 675635008549 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635008550 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 675635008551 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635008552 putative ADP-binding pocket [chemical binding]; other site 675635008553 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 675635008554 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 675635008555 Flavoprotein; Region: Flavoprotein; cl08021 675635008556 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 675635008557 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 675635008558 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 675635008559 catalytic site [active] 675635008560 G-X2-G-X-G-K; other site 675635008561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635008562 active site 675635008563 phosphorylation site [posttranslational modification] 675635008564 intermolecular recognition site; other site 675635008565 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 675635008566 active site 675635008567 dimer interface [polypeptide binding]; other site 675635008568 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 675635008569 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635008570 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635008571 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 675635008572 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635008573 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635008574 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 675635008575 IMP binding site; other site 675635008576 dimer interface [polypeptide binding]; other site 675635008577 interdomain contacts; other site 675635008578 partial ornithine binding site; other site 675635008579 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 675635008580 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 675635008581 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 675635008582 catalytic site [active] 675635008583 subunit interface [polypeptide binding]; other site 675635008584 dihydroorotase; Validated; Region: pyrC; PRK09357 675635008585 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635008586 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 675635008587 active site 675635008588 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 675635008589 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 675635008590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008591 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 675635008592 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 675635008593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635008594 non-specific DNA binding site [nucleotide binding]; other site 675635008595 salt bridge; other site 675635008596 sequence-specific DNA binding site [nucleotide binding]; other site 675635008597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635008598 putative substrate translocation pore; other site 675635008599 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 675635008600 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 675635008601 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 675635008602 putative RNA binding site [nucleotide binding]; other site 675635008603 elongation factor P; Validated; Region: PRK00529 675635008604 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 675635008605 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 675635008606 RNA binding site [nucleotide binding]; other site 675635008607 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 675635008608 RNA binding site [nucleotide binding]; other site 675635008609 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 675635008610 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 675635008611 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 675635008612 active site 675635008613 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 675635008614 active site 675635008615 dimer interface [polypeptide binding]; other site 675635008616 metal binding site [ion binding]; metal-binding site 675635008617 shikimate kinase; Reviewed; Region: aroK; PRK00131 675635008618 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 675635008619 ADP binding site [chemical binding]; other site 675635008620 magnesium binding site [ion binding]; other site 675635008621 putative shikimate binding site; other site 675635008622 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 675635008623 Tetramer interface [polypeptide binding]; other site 675635008624 active site 675635008625 FMN-binding site [chemical binding]; other site 675635008626 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635008627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 675635008628 YceG-like family; Region: YceG; pfam02618 675635008629 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 675635008630 dimerization interface [polypeptide binding]; other site 675635008631 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 675635008632 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 675635008633 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 675635008634 motif 1; other site 675635008635 active site 675635008636 motif 2; other site 675635008637 motif 3; other site 675635008638 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 675635008639 DHHA1 domain; Region: DHHA1; pfam02272 675635008640 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635008641 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635008642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635008643 DNA binding residues [nucleotide binding] 675635008644 Helix-turn-helix domains; Region: HTH; cl00088 675635008645 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635008646 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 675635008647 inhibitor-cofactor binding pocket; inhibition site 675635008648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635008649 catalytic residue [active] 675635008650 Helix-turn-helix domains; Region: HTH; cl00088 675635008651 Amidinotransferase; Region: Amidinotransf; cl12043 675635008652 hypothetical protein; Provisional; Region: PRK07588 675635008653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008654 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 675635008655 Helix-turn-helix domains; Region: HTH; cl00088 675635008656 Transposase domain (DUF772); Region: DUF772; cl15789 675635008657 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635008658 Transposase domain (DUF772); Region: DUF772; cl15789 675635008659 amidase; Provisional; Region: PRK07869 675635008660 Amidase; Region: Amidase; cl11426 675635008661 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635008662 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635008663 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 675635008664 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635008665 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 675635008666 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 675635008667 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 675635008668 active site 675635008669 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 675635008670 Helix-turn-helix domains; Region: HTH; cl00088 675635008671 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635008672 recombination factor protein RarA; Reviewed; Region: PRK13342 675635008673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635008674 Walker A motif; other site 675635008675 ATP binding site [chemical binding]; other site 675635008676 Walker B motif; other site 675635008677 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 675635008678 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 675635008679 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635008680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635008681 homodimer interface [polypeptide binding]; other site 675635008682 catalytic residue [active] 675635008683 Helix-turn-helix domains; Region: HTH; cl00088 675635008684 Helix-turn-helix domains; Region: HTH; cl00088 675635008685 hypothetical protein; Validated; Region: PRK07682 675635008686 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635008687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635008688 homodimer interface [polypeptide binding]; other site 675635008689 catalytic residue [active] 675635008690 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635008691 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635008692 active site 675635008693 oxyanion hole [active] 675635008694 catalytic triad [active] 675635008695 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 675635008696 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 675635008697 dimer interface [polypeptide binding]; other site 675635008698 anticodon binding site; other site 675635008699 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 675635008700 homodimer interface [polypeptide binding]; other site 675635008701 motif 1; other site 675635008702 active site 675635008703 motif 2; other site 675635008704 GAD domain; Region: GAD; pfam02938 675635008705 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 675635008706 active site 675635008707 motif 3; other site 675635008708 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 675635008709 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 675635008710 protein-splicing catalytic site; other site 675635008711 thioester formation/cholesterol transfer; other site 675635008712 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 675635008713 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 675635008714 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 675635008715 YibE/F-like protein; Region: YibE_F; cl02259 675635008716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008717 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 675635008718 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 675635008719 motif 1; other site 675635008720 dimer interface [polypeptide binding]; other site 675635008721 active site 675635008722 motif 2; other site 675635008723 motif 3; other site 675635008724 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 675635008725 anticodon binding site; other site 675635008726 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 675635008727 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635008728 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 675635008729 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 675635008730 active site 675635008731 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 675635008732 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 675635008733 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 675635008734 synthetase active site [active] 675635008735 NTP binding site [chemical binding]; other site 675635008736 metal binding site [ion binding]; metal-binding site 675635008737 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 675635008738 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 675635008739 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 675635008740 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 675635008741 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 675635008742 Protein export membrane protein; Region: SecD_SecF; cl14618 675635008743 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 675635008744 Protein export membrane protein; Region: SecD_SecF; cl14618 675635008745 Preprotein translocase subunit; Region: YajC; cl00806 675635008746 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 675635008747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635008748 Walker A motif; other site 675635008749 ATP binding site [chemical binding]; other site 675635008750 Walker B motif; other site 675635008751 arginine finger; other site 675635008752 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 675635008753 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 675635008754 RuvA N terminal domain; Region: RuvA_N; pfam01330 675635008755 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 675635008756 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 675635008757 active site 675635008758 putative DNA-binding cleft [nucleotide binding]; other site 675635008759 dimer interface [polypeptide binding]; other site 675635008760 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635008761 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635008762 active site 675635008763 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 675635008764 5'-3' exonuclease; Region: 53EXOc; smart00475 675635008765 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 675635008766 active site 675635008767 metal binding site 1 [ion binding]; metal-binding site 675635008768 putative 5' ssDNA interaction site; other site 675635008769 metal binding site 3; metal-binding site 675635008770 metal binding site 2 [ion binding]; metal-binding site 675635008771 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 675635008772 putative DNA binding site [nucleotide binding]; other site 675635008773 putative metal binding site [ion binding]; other site 675635008774 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 675635008775 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 675635008776 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 675635008777 active site 675635008778 DNA binding site [nucleotide binding] 675635008779 catalytic site [active] 675635008780 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 675635008781 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 675635008782 putative metal binding site [ion binding]; other site 675635008783 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 675635008784 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 675635008785 putative metal binding site [ion binding]; other site 675635008786 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 675635008787 tellurite resistance protein terB; Region: terB; cd07176 675635008788 putative metal binding site [ion binding]; other site 675635008789 Integral membrane protein TerC family; Region: TerC; cl10468 675635008790 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 675635008791 putative metal binding site [ion binding]; other site 675635008792 Transcriptional regulator; Region: Transcrip_reg; cl00361 675635008793 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 675635008794 predicted active site [active] 675635008795 catalytic triad [active] 675635008796 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 675635008797 Malic enzyme, N-terminal domain; Region: malic; pfam00390 675635008798 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 675635008799 putative NAD(P) binding site [chemical binding]; other site 675635008800 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 675635008801 elongation factor G; Reviewed; Region: PRK12740 675635008802 G1 box; other site 675635008803 putative GEF interaction site [polypeptide binding]; other site 675635008804 GTP/Mg2+ binding site [chemical binding]; other site 675635008805 Switch I region; other site 675635008806 G2 box; other site 675635008807 G3 box; other site 675635008808 Switch II region; other site 675635008809 G4 box; other site 675635008810 G5 box; other site 675635008811 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 675635008812 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 675635008813 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 675635008814 AzlC protein; Region: AzlC; cl00570 675635008815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635008816 non-specific DNA binding site [nucleotide binding]; other site 675635008817 salt bridge; other site 675635008818 sequence-specific DNA binding site [nucleotide binding]; other site 675635008819 Cupin domain; Region: Cupin_2; cl09118 675635008820 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 675635008821 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 675635008822 iron-sulfur cluster [ion binding]; other site 675635008823 [2Fe-2S] cluster binding site [ion binding]; other site 675635008824 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 675635008825 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 675635008826 active site 675635008827 multimer interface [polypeptide binding]; other site 675635008828 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635008829 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 675635008830 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 675635008831 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635008832 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 675635008833 putative acyl-acceptor binding pocket; other site 675635008834 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 675635008835 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 675635008836 nucleotide binding site/active site [active] 675635008837 HIT family signature motif; other site 675635008838 catalytic residue [active] 675635008839 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 675635008840 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 675635008841 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 675635008842 active site 675635008843 dimer interface [polypeptide binding]; other site 675635008844 motif 1; other site 675635008845 motif 2; other site 675635008846 motif 3; other site 675635008847 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 675635008848 anticodon binding site; other site 675635008849 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 675635008850 Transglycosylase; Region: Transgly; cl07896 675635008851 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635008852 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635008853 active site 675635008854 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 675635008855 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635008856 DNA binding residues [nucleotide binding] 675635008857 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 675635008858 PAS fold; Region: PAS; pfam00989 675635008859 PAS fold; Region: PAS_4; pfam08448 675635008860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635008861 putative active site [active] 675635008862 PAS fold; Region: PAS_3; pfam08447 675635008863 heme pocket [chemical binding]; other site 675635008864 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 675635008865 GAF domain; Region: GAF; cl15785 675635008866 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 675635008867 Protein of unknown function (DUF419); Region: DUF419; cl15265 675635008868 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635008869 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635008870 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635008871 Pirin-related protein [General function prediction only]; Region: COG1741 675635008872 Cupin domain; Region: Cupin_2; cl09118 675635008873 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 675635008874 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635008875 SNF2 Helicase protein; Region: DUF3670; pfam12419 675635008876 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 675635008877 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635008878 ATP binding site [chemical binding]; other site 675635008879 putative Mg++ binding site [ion binding]; other site 675635008880 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635008881 nucleotide binding region [chemical binding]; other site 675635008882 ATP-binding site [chemical binding]; other site 675635008883 SWIM zinc finger; Region: SWIM; cl15408 675635008884 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 675635008885 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 675635008886 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 675635008887 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635008888 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635008889 catalytic residue [active] 675635008890 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 675635008891 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 675635008892 GTP cyclohydrolase I; Provisional; Region: PLN03044 675635008893 active site 675635008894 Helix-turn-helix domains; Region: HTH; cl00088 675635008895 Predicted transcriptional regulator [Transcription]; Region: COG2345 675635008896 Transglycosylase; Region: Transgly; cl07896 675635008897 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 675635008898 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635008899 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 675635008900 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 675635008901 classical (c) SDRs; Region: SDR_c; cd05233 675635008902 NAD(P) binding site [chemical binding]; other site 675635008903 active site 675635008904 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 675635008905 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 675635008906 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 675635008907 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 675635008908 shikimate binding site; other site 675635008909 NAD(P) binding site [chemical binding]; other site 675635008910 hypothetical protein; Provisional; Region: PRK08317 675635008911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635008912 S-adenosylmethionine binding site [chemical binding]; other site 675635008913 Helix-turn-helix domains; Region: HTH; cl00088 675635008914 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 675635008915 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635008916 Walker A/P-loop; other site 675635008917 ATP binding site [chemical binding]; other site 675635008918 Q-loop/lid; other site 675635008919 ABC transporter signature motif; other site 675635008920 Walker B; other site 675635008921 D-loop; other site 675635008922 H-loop/switch region; other site 675635008923 ABC-2 type transporter; Region: ABC2_membrane; cl11417 675635008924 phosphoglucomutase; Validated; Region: PRK07564 675635008925 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 675635008926 active site 675635008927 substrate binding site [chemical binding]; other site 675635008928 metal binding site [ion binding]; metal-binding site 675635008929 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 675635008930 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 675635008931 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635008932 anti sigma factor interaction site; other site 675635008933 regulatory phosphorylation site [posttranslational modification]; other site 675635008934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008935 hypothetical protein; Provisional; Region: PRK06834 675635008936 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635008937 Helix-turn-helix domains; Region: HTH; cl00088 675635008938 DinB superfamily; Region: DinB_2; pfam12867 675635008939 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635008940 RNA polymerase factor sigma-70; Validated; Region: PRK08241 675635008941 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635008942 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635008943 DNA binding residues [nucleotide binding] 675635008944 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635008945 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 675635008946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635008948 Domain of unknown function (DUF397); Region: DUF397; pfam04149 675635008949 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635008950 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 675635008951 galactokinase; Provisional; Region: PRK00555 675635008952 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 675635008953 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 675635008954 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 675635008955 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 675635008956 dimer interface [polypeptide binding]; other site 675635008957 active site 675635008958 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 675635008959 Helix-turn-helix domains; Region: HTH; cl00088 675635008960 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 675635008961 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 675635008962 Sodium:solute symporter family; Region: SSF; cl00456 675635008963 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 675635008964 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635008965 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635008966 active site 675635008967 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635008968 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635008969 DNA-binding site [nucleotide binding]; DNA binding site 675635008970 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 675635008971 N- and C-terminal domain interface [polypeptide binding]; other site 675635008972 active site 675635008973 MgATP binding site [chemical binding]; other site 675635008974 catalytic site [active] 675635008975 metal binding site [ion binding]; metal-binding site 675635008976 carbohydrate binding site [chemical binding]; other site 675635008977 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 675635008978 intersubunit interface [polypeptide binding]; other site 675635008979 active site 675635008980 Zn2+ binding site [ion binding]; other site 675635008981 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 675635008982 Helix-turn-helix domains; Region: HTH; cl00088 675635008983 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 675635008984 substrate binding pocket [chemical binding]; other site 675635008985 aspartate-rich region 2; other site 675635008986 substrate-Mg2+ binding site; other site 675635008987 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 675635008988 active site lid residues [active] 675635008989 substrate binding pocket [chemical binding]; other site 675635008990 catalytic residues [active] 675635008991 substrate-Mg2+ binding site; other site 675635008992 aspartate-rich region 1; other site 675635008993 aspartate-rich region 2; other site 675635008994 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 675635008995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008996 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 675635008997 substrate binding pocket [chemical binding]; other site 675635008998 chain length determination region; other site 675635008999 substrate-Mg2+ binding site; other site 675635009000 catalytic residues [active] 675635009001 aspartate-rich region 1; other site 675635009002 active site lid residues [active] 675635009003 aspartate-rich region 2; other site 675635009004 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 675635009005 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 675635009006 Active site cavity [active] 675635009007 catalytic acid [active] 675635009008 LytB protein; Region: LYTB; cl00507 675635009009 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 675635009010 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 675635009011 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635009012 FeS/SAM binding site; other site 675635009013 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 675635009014 Intracellular septation protein A; Region: IspA; cl01098 675635009015 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 675635009016 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635009017 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 675635009018 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 675635009019 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 675635009020 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 675635009021 classical (c) SDRs; Region: SDR_c; cd05233 675635009022 NAD(P) binding site [chemical binding]; other site 675635009023 active site 675635009024 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 675635009025 trimer interface [polypeptide binding]; other site 675635009026 active site 675635009027 dimer interface [polypeptide binding]; other site 675635009028 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635009029 Coenzyme A binding pocket [chemical binding]; other site 675635009030 Helix-turn-helix domains; Region: HTH; cl00088 675635009031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635009032 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 675635009033 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635009034 Walker A/P-loop; other site 675635009035 ATP binding site [chemical binding]; other site 675635009036 Q-loop/lid; other site 675635009037 ABC transporter signature motif; other site 675635009038 Walker B; other site 675635009039 D-loop; other site 675635009040 H-loop/switch region; other site 675635009041 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635009042 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 675635009043 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635009044 Walker A/P-loop; other site 675635009045 ATP binding site [chemical binding]; other site 675635009046 Q-loop/lid; other site 675635009047 ABC transporter signature motif; other site 675635009048 Walker B; other site 675635009049 D-loop; other site 675635009050 H-loop/switch region; other site 675635009051 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635009052 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635009053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635009054 dimer interface [polypeptide binding]; other site 675635009055 conserved gate region; other site 675635009056 putative PBP binding loops; other site 675635009057 ABC-ATPase subunit interface; other site 675635009058 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635009059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635009060 dimer interface [polypeptide binding]; other site 675635009061 conserved gate region; other site 675635009062 putative PBP binding loops; other site 675635009063 ABC-ATPase subunit interface; other site 675635009064 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 675635009065 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 675635009066 4Fe-4S binding domain; Region: Fer4; cl02805 675635009067 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635009068 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635009069 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 675635009070 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635009071 hydrophobic ligand binding site; other site 675635009072 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 675635009073 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635009074 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635009075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635009076 DNA-binding site [nucleotide binding]; DNA binding site 675635009077 FCD domain; Region: FCD; cl11656 675635009078 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 675635009079 substrate binding site [chemical binding]; other site 675635009080 THF binding site; other site 675635009081 zinc-binding site [ion binding]; other site 675635009082 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635009083 Muconolactone delta-isomerase; Region: MIase; cl01992 675635009084 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 675635009085 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635009086 PYR/PP interface [polypeptide binding]; other site 675635009087 dimer interface [polypeptide binding]; other site 675635009088 TPP binding site [chemical binding]; other site 675635009089 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 675635009090 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635009091 TPP-binding site [chemical binding]; other site 675635009092 short chain dehydrogenase; Validated; Region: PRK05855 675635009093 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635009094 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 675635009095 alpha subunit interface [polypeptide binding]; other site 675635009096 TPP binding site [chemical binding]; other site 675635009097 heterodimer interface [polypeptide binding]; other site 675635009098 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635009099 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635009100 tetramer interface [polypeptide binding]; other site 675635009101 TPP-binding site [chemical binding]; other site 675635009102 heterodimer interface [polypeptide binding]; other site 675635009103 phosphorylation loop region [posttranslational modification] 675635009104 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635009105 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 675635009106 PYR/PP interface [polypeptide binding]; other site 675635009107 dimer interface [polypeptide binding]; other site 675635009108 TPP binding site [chemical binding]; other site 675635009109 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635009110 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 675635009111 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635009112 tetramer interface [polypeptide binding]; other site 675635009113 TPP-binding site [chemical binding]; other site 675635009114 heterodimer interface [polypeptide binding]; other site 675635009115 phosphorylation loop region [posttranslational modification] 675635009116 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 675635009117 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635009118 E3 interaction surface; other site 675635009119 lipoyl attachment site [posttranslational modification]; other site 675635009120 e3 binding domain; Region: E3_binding; pfam02817 675635009121 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 675635009122 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 675635009123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635009124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009125 NAD(P) binding site [chemical binding]; other site 675635009126 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 675635009127 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 675635009128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009129 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635009130 Helix-turn-helix domains; Region: HTH; cl00088 675635009131 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635009132 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635009133 classical (c) SDRs; Region: SDR_c; cd05233 675635009134 NAD(P) binding site [chemical binding]; other site 675635009135 active site 675635009136 Putative cyclase; Region: Cyclase; cl00814 675635009137 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 675635009138 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635009139 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635009140 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635009141 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635009142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009143 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 675635009144 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635009145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009146 NAD(P) binding site [chemical binding]; other site 675635009147 active site 675635009148 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635009149 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635009150 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 675635009151 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 675635009152 DNA interaction; other site 675635009153 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635009154 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 675635009155 alpha subunit interface [polypeptide binding]; other site 675635009156 TPP binding site [chemical binding]; other site 675635009157 heterodimer interface [polypeptide binding]; other site 675635009158 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635009159 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635009160 tetramer interface [polypeptide binding]; other site 675635009161 TPP-binding site [chemical binding]; other site 675635009162 heterodimer interface [polypeptide binding]; other site 675635009163 phosphorylation loop region [posttranslational modification] 675635009164 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635009165 classical (c) SDRs; Region: SDR_c; cd05233 675635009166 NAD(P) binding site [chemical binding]; other site 675635009167 active site 675635009168 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635009169 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635009170 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635009171 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 675635009172 Walker A/P-loop; other site 675635009173 ATP binding site [chemical binding]; other site 675635009174 Q-loop/lid; other site 675635009175 ABC transporter signature motif; other site 675635009176 Walker B; other site 675635009177 D-loop; other site 675635009178 H-loop/switch region; other site 675635009179 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635009180 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 675635009181 Walker A/P-loop; other site 675635009182 ATP binding site [chemical binding]; other site 675635009183 Q-loop/lid; other site 675635009184 ABC transporter signature motif; other site 675635009185 Walker B; other site 675635009186 D-loop; other site 675635009187 H-loop/switch region; other site 675635009188 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635009189 TM-ABC transporter signature motif; other site 675635009190 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635009191 TM-ABC transporter signature motif; other site 675635009192 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635009193 Helix-turn-helix domains; Region: HTH; cl00088 675635009194 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635009195 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 675635009196 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635009197 active site 675635009198 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 675635009199 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635009200 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635009201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009202 NAD(P) binding site [chemical binding]; other site 675635009203 AMP-binding domain protein; Validated; Region: PRK08315 675635009204 AMP-binding enzyme; Region: AMP-binding; cl15778 675635009205 AMP-binding enzyme; Region: AMP-binding; cl15778 675635009206 Putative cyclase; Region: Cyclase; cl00814 675635009207 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635009208 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635009209 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 675635009210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009211 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635009212 Cupin domain; Region: Cupin_2; cl09118 675635009213 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635009214 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635009215 Spore germination protein; Region: Spore_permease; cl15802 675635009216 Amino acid permease; Region: AA_permease; pfam00324 675635009217 tyramine oxidase; Provisional; Region: tynA; PRK11504 675635009218 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 675635009219 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 675635009220 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 675635009221 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635009222 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635009223 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635009224 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635009225 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635009226 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635009227 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635009228 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 675635009229 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635009230 hydrophobic ligand binding site; other site 675635009231 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635009232 Helix-turn-helix domains; Region: HTH; cl00088 675635009233 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635009234 putative sialic acid transporter; Region: 2A0112; TIGR00891 675635009235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635009236 putative substrate translocation pore; other site 675635009237 benzoate transport; Region: 2A0115; TIGR00895 675635009238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635009239 putative substrate translocation pore; other site 675635009240 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 675635009241 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 675635009242 active site 675635009243 FMN binding site [chemical binding]; other site 675635009244 substrate binding site [chemical binding]; other site 675635009245 3Fe-4S cluster binding site [ion binding]; other site 675635009246 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 675635009247 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635009248 tetrameric interface [polypeptide binding]; other site 675635009249 NAD binding site [chemical binding]; other site 675635009250 catalytic residues [active] 675635009251 short chain dehydrogenase; Provisional; Region: PRK06180 675635009252 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 675635009253 NADP binding site [chemical binding]; other site 675635009254 active site 675635009255 steroid binding site; other site 675635009256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009257 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 675635009258 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 675635009259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635009260 DNA-binding site [nucleotide binding]; DNA binding site 675635009261 FCD domain; Region: FCD; cl11656 675635009262 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635009263 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 675635009264 putative NAD(P) binding site [chemical binding]; other site 675635009265 active site 675635009266 putative substrate binding site [chemical binding]; other site 675635009267 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 675635009268 Cation efflux family; Region: Cation_efflux; cl00316 675635009269 YCII-related domain; Region: YCII; cl00999 675635009270 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 675635009271 putative hydrophobic ligand binding site [chemical binding]; other site 675635009272 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635009273 dimerization interface [polypeptide binding]; other site 675635009274 putative DNA binding site [nucleotide binding]; other site 675635009275 putative Zn2+ binding site [ion binding]; other site 675635009276 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 675635009277 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635009278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635009279 YCII-related domain; Region: YCII; cl00999 675635009280 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635009281 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635009282 active site 675635009283 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635009284 DNA polymerase IV; Validated; Region: PRK03858 675635009285 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 675635009286 active site 675635009287 DNA binding site [nucleotide binding] 675635009288 Helix-turn-helix domains; Region: HTH; cl00088 675635009289 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 675635009290 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635009291 MULE transposase domain; Region: MULE; pfam10551 675635009292 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635009293 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635009294 NAD synthetase; Reviewed; Region: nadE; PRK02628 675635009295 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 675635009296 multimer interface [polypeptide binding]; other site 675635009297 active site 675635009298 catalytic triad [active] 675635009299 protein interface 1 [polypeptide binding]; other site 675635009300 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 675635009301 homodimer interface [polypeptide binding]; other site 675635009302 NAD binding pocket [chemical binding]; other site 675635009303 ATP binding pocket [chemical binding]; other site 675635009304 Mg binding site [ion binding]; other site 675635009305 active-site loop [active] 675635009306 Predicted membrane protein [Function unknown]; Region: COG2860 675635009307 FOG: CBS domain [General function prediction only]; Region: COG0517 675635009308 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635009309 FOG: CBS domain [General function prediction only]; Region: COG0517 675635009310 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635009311 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 675635009312 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635009313 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 675635009314 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 675635009315 putative active site [active] 675635009316 putative metal binding site [ion binding]; other site 675635009317 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 675635009318 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635009319 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635009320 amino acid transporter; Region: 2A0306; TIGR00909 675635009321 Spore germination protein; Region: Spore_permease; cl15802 675635009322 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635009323 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635009324 DNA binding residues [nucleotide binding] 675635009325 dimerization interface [polypeptide binding]; other site 675635009326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009327 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 675635009328 Helix-turn-helix domains; Region: HTH; cl00088 675635009329 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 675635009330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635009331 S-adenosylmethionine binding site [chemical binding]; other site 675635009332 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 675635009333 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635009334 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 675635009335 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 675635009336 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635009337 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 675635009338 putative ligand binding site [chemical binding]; other site 675635009339 Helix-turn-helix domains; Region: HTH; cl00088 675635009340 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635009341 GTP-binding protein Der; Reviewed; Region: PRK03003 675635009342 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 675635009343 G1 box; other site 675635009344 GTP/Mg2+ binding site [chemical binding]; other site 675635009345 Switch I region; other site 675635009346 G2 box; other site 675635009347 Switch II region; other site 675635009348 G3 box; other site 675635009349 G4 box; other site 675635009350 G5 box; other site 675635009351 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 675635009352 G1 box; other site 675635009353 GTP/Mg2+ binding site [chemical binding]; other site 675635009354 Switch I region; other site 675635009355 G2 box; other site 675635009356 G3 box; other site 675635009357 Switch II region; other site 675635009358 G4 box; other site 675635009359 G5 box; other site 675635009360 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 675635009361 putative acyl-acceptor binding pocket; other site 675635009362 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 675635009363 cytidylate kinase; Region: cmk; TIGR00017 675635009364 CMP-binding site; other site 675635009365 The sites determining sugar specificity; other site 675635009366 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 675635009367 homotrimer interaction site [polypeptide binding]; other site 675635009368 active site 675635009369 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 675635009370 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 675635009371 RNA binding surface [nucleotide binding]; other site 675635009372 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 675635009373 active site 675635009374 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 675635009375 ScpA/B protein; Region: ScpA_ScpB; cl00598 675635009376 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 675635009377 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635009378 P-loop; other site 675635009379 Magnesium ion binding site [ion binding]; other site 675635009380 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635009381 Magnesium ion binding site [ion binding]; other site 675635009382 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 675635009383 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635009384 active site 675635009385 DNA binding site [nucleotide binding] 675635009386 Int/Topo IB signature motif; other site 675635009387 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635009388 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635009389 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 675635009390 dimer interface [polypeptide binding]; other site 675635009391 ADP-ribose binding site [chemical binding]; other site 675635009392 active site 675635009393 nudix motif; other site 675635009394 metal binding site [ion binding]; metal-binding site 675635009395 CTP synthetase; Validated; Region: pyrG; PRK05380 675635009396 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 675635009397 Catalytic site [active] 675635009398 active site 675635009399 UTP binding site [chemical binding]; other site 675635009400 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 675635009401 active site 675635009402 putative oxyanion hole; other site 675635009403 catalytic triad [active] 675635009404 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 675635009405 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 675635009406 DNA repair protein RecN; Region: recN; TIGR00634 675635009407 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 675635009408 Walker A/P-loop; other site 675635009409 ATP binding site [chemical binding]; other site 675635009410 Q-loop/lid; other site 675635009411 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 675635009412 ABC transporter signature motif; other site 675635009413 Walker B; other site 675635009414 D-loop; other site 675635009415 H-loop/switch region; other site 675635009416 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 675635009417 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 675635009418 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 675635009419 RNA binding surface [nucleotide binding]; other site 675635009420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 675635009421 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 675635009422 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635009423 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635009424 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 675635009425 active site 675635009426 DNA binding site [nucleotide binding] 675635009427 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 675635009428 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635009429 DNA binding residues [nucleotide binding] 675635009430 dimer interface [polypeptide binding]; other site 675635009431 argininosuccinate lyase; Provisional; Region: PRK00855 675635009432 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 675635009433 active sites [active] 675635009434 tetramer interface [polypeptide binding]; other site 675635009435 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 675635009436 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635009437 Ligand Binding Site [chemical binding]; other site 675635009438 arginine repressor; Provisional; Region: PRK03341 675635009439 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 675635009440 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 675635009441 ornithine carbamoyltransferase; Provisional; Region: PRK00779 675635009442 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 675635009443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009444 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 675635009445 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635009446 inhibitor-cofactor binding pocket; inhibition site 675635009447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635009448 catalytic residue [active] 675635009449 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 675635009450 feedback inhibition sensing region; other site 675635009451 homohexameric interface [polypeptide binding]; other site 675635009452 nucleotide binding site [chemical binding]; other site 675635009453 N-acetyl-L-glutamate binding site [chemical binding]; other site 675635009454 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 675635009455 heterotetramer interface [polypeptide binding]; other site 675635009456 active site pocket [active] 675635009457 cleavage site 675635009458 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 675635009459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009460 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 675635009461 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 675635009462 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 675635009463 active site 675635009464 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 675635009465 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 675635009466 putative tRNA-binding site [nucleotide binding]; other site 675635009467 B3/4 domain; Region: B3_4; cl11458 675635009468 tRNA synthetase B5 domain; Region: B5; cl08394 675635009469 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 675635009470 dimer interface [polypeptide binding]; other site 675635009471 motif 1; other site 675635009472 motif 3; other site 675635009473 motif 2; other site 675635009474 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 675635009475 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 675635009476 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 675635009477 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 675635009478 dimer interface [polypeptide binding]; other site 675635009479 motif 1; other site 675635009480 active site 675635009481 motif 2; other site 675635009482 motif 3; other site 675635009483 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 675635009484 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 675635009485 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 675635009486 ribosomal protein L20; Region: rpl20; CHL00068 675635009487 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 675635009488 23S rRNA binding site [nucleotide binding]; other site 675635009489 L21 binding site [polypeptide binding]; other site 675635009490 L13 binding site [polypeptide binding]; other site 675635009491 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 675635009492 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 675635009493 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 675635009494 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 675635009495 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 675635009496 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 675635009497 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 675635009498 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 675635009499 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635009500 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635009501 hydrophobic ligand binding site; other site 675635009502 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 675635009503 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 675635009504 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635009505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635009506 putative substrate translocation pore; other site 675635009507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635009508 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 675635009509 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 675635009510 active site 675635009511 metal binding site [ion binding]; metal-binding site 675635009512 homotetramer interface [polypeptide binding]; other site 675635009513 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 675635009514 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635009515 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 675635009516 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 675635009517 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 675635009518 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635009519 Walker A/P-loop; other site 675635009520 ATP binding site [chemical binding]; other site 675635009521 Q-loop/lid; other site 675635009522 ABC transporter signature motif; other site 675635009523 Walker B; other site 675635009524 D-loop; other site 675635009525 H-loop/switch region; other site 675635009526 ABC-2 type transporter; Region: ABC2_membrane; cl11417 675635009527 EamA-like transporter family; Region: EamA; cl01037 675635009528 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 675635009529 EamA-like transporter family; Region: EamA; cl01037 675635009530 Helix-turn-helix domains; Region: HTH; cl00088 675635009531 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635009532 dimerization interface [polypeptide binding]; other site 675635009533 Helix-turn-helix domains; Region: HTH; cl00088 675635009534 Predicted membrane protein [Function unknown]; Region: COG4270 675635009535 Protein of unknown function (DUF419); Region: DUF419; cl15265 675635009536 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 675635009537 excinuclease ABC subunit B; Provisional; Region: PRK05298 675635009538 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635009539 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635009540 nucleotide binding region [chemical binding]; other site 675635009541 ATP-binding site [chemical binding]; other site 675635009542 Ultra-violet resistance protein B; Region: UvrB; pfam12344 675635009543 UvrB/uvrC motif; Region: UVR; pfam02151 675635009544 Protein of unknown function (DUF402); Region: DUF402; cl00979 675635009545 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 675635009546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635009547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635009548 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 675635009549 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 675635009550 CoA-binding site [chemical binding]; other site 675635009551 ATP-binding [chemical binding]; other site 675635009552 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 675635009553 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 675635009554 RNA binding site [nucleotide binding]; other site 675635009555 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 675635009556 RNA binding site [nucleotide binding]; other site 675635009557 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 675635009558 RNA binding site [nucleotide binding]; other site 675635009559 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 675635009560 RNA binding site [nucleotide binding]; other site 675635009561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635009562 S-adenosylmethionine binding site [chemical binding]; other site 675635009563 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 675635009564 CoenzymeA binding site [chemical binding]; other site 675635009565 subunit interaction site [polypeptide binding]; other site 675635009566 PHB binding site; other site 675635009567 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 675635009568 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 675635009569 dimerization interface [polypeptide binding]; other site 675635009570 ligand binding site [chemical binding]; other site 675635009571 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635009572 TM-ABC transporter signature motif; other site 675635009573 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635009574 TM-ABC transporter signature motif; other site 675635009575 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635009576 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 675635009577 Walker A/P-loop; other site 675635009578 ATP binding site [chemical binding]; other site 675635009579 Q-loop/lid; other site 675635009580 ABC transporter signature motif; other site 675635009581 Walker B; other site 675635009582 D-loop; other site 675635009583 H-loop/switch region; other site 675635009584 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635009585 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 675635009586 Walker A/P-loop; other site 675635009587 ATP binding site [chemical binding]; other site 675635009588 Q-loop/lid; other site 675635009589 ABC transporter signature motif; other site 675635009590 Walker B; other site 675635009591 D-loop; other site 675635009592 H-loop/switch region; other site 675635009593 Response regulator receiver domain; Region: Response_reg; pfam00072 675635009594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635009595 active site 675635009596 phosphorylation site [posttranslational modification] 675635009597 intermolecular recognition site; other site 675635009598 dimerization interface [polypeptide binding]; other site 675635009599 ANTAR domain; Region: ANTAR; cl04297 675635009600 Right handed beta helix region; Region: Beta_helix; pfam13229 675635009601 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 675635009602 active site 675635009603 acceptor substrate-binding pocket; other site 675635009604 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635009605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635009606 active site 675635009607 phosphorylation site [posttranslational modification] 675635009608 intermolecular recognition site; other site 675635009609 dimerization interface [polypeptide binding]; other site 675635009610 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635009611 DNA binding residues [nucleotide binding] 675635009612 dimerization interface [polypeptide binding]; other site 675635009613 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 675635009614 catalytic residues [active] 675635009615 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635009616 Helix-turn-helix domains; Region: HTH; cl00088 675635009617 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635009618 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 675635009619 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 675635009620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009621 glyoxylate carboligase; Provisional; Region: PRK11269 675635009622 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635009623 PYR/PP interface [polypeptide binding]; other site 675635009624 dimer interface [polypeptide binding]; other site 675635009625 TPP binding site [chemical binding]; other site 675635009626 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 675635009627 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635009628 TPP-binding site [chemical binding]; other site 675635009629 Glycerate kinase family; Region: Gly_kinase; cl00841 675635009630 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 675635009631 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635009632 DNA-binding site [nucleotide binding]; DNA binding site 675635009633 UTRA domain; Region: UTRA; cl01230 675635009634 chorismate binding enzyme; Region: Chorismate_bind; cl10555 675635009635 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 675635009636 substrate-cofactor binding pocket; other site 675635009637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 675635009638 Bacterial Ig-like domain; Region: Big_5; cl01012 675635009639 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 675635009640 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 675635009641 Helix-turn-helix domains; Region: HTH; cl00088 675635009642 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 675635009643 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635009644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009645 NAD(P) binding site [chemical binding]; other site 675635009646 active site 675635009647 acyl-CoA synthetase; Validated; Region: PRK06188 675635009648 AMP-binding enzyme; Region: AMP-binding; cl15778 675635009649 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 675635009650 Helix-turn-helix domains; Region: HTH; cl00088 675635009651 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 675635009652 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 675635009653 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635009654 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635009655 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635009656 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635009657 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635009658 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635009659 Helix-turn-helix domains; Region: HTH; cl00088 675635009660 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 675635009661 dimerization interface [polypeptide binding]; other site 675635009662 substrate binding pocket [chemical binding]; other site 675635009663 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 675635009664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009665 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 675635009666 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 675635009667 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 675635009668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635009669 Coenzyme A binding pocket [chemical binding]; other site 675635009670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009671 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 675635009672 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635009673 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635009674 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635009675 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 675635009676 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635009677 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 675635009678 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 675635009679 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 675635009680 FAD binding domain; Region: FAD_binding_4; pfam01565 675635009681 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635009682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635009683 DNA-binding site [nucleotide binding]; DNA binding site 675635009684 FCD domain; Region: FCD; cl11656 675635009685 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 675635009686 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635009687 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 675635009688 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635009689 hydrophobic ligand binding site; other site 675635009690 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 675635009691 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 675635009692 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635009693 hydrophobic ligand binding site; other site 675635009694 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635009695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009696 NAD(P) binding site [chemical binding]; other site 675635009697 hypothetical protein; Provisional; Region: PRK06154 675635009698 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635009699 PYR/PP interface [polypeptide binding]; other site 675635009700 dimer interface [polypeptide binding]; other site 675635009701 TPP binding site [chemical binding]; other site 675635009702 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 675635009703 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 675635009704 TPP-binding site; other site 675635009705 dimer interface [polypeptide binding]; other site 675635009706 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635009707 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635009708 D-galactonate transporter; Region: 2A0114; TIGR00893 675635009709 PAC2 family; Region: PAC2; cl00847 675635009710 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635009711 TPP-binding site [chemical binding]; other site 675635009712 transketolase; Reviewed; Region: PRK05899 675635009713 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 675635009714 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635009715 Helix-turn-helix domains; Region: HTH; cl00088 675635009716 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635009717 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635009718 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 675635009719 NAD(P) binding site [chemical binding]; other site 675635009720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635009721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635009722 DNA-binding site [nucleotide binding]; DNA binding site 675635009723 FCD domain; Region: FCD; cl11656 675635009724 DNA polymerase IV; Validated; Region: PRK03352 675635009725 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 675635009726 active site 675635009727 DNA binding site [nucleotide binding] 675635009728 NurA domain; Region: NurA; cl09134 675635009729 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 675635009730 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635009731 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 675635009732 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635009733 Walker A/P-loop; other site 675635009734 ATP binding site [chemical binding]; other site 675635009735 Q-loop/lid; other site 675635009736 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635009737 ABC transporter signature motif; other site 675635009738 Walker B; other site 675635009739 D-loop; other site 675635009740 H-loop/switch region; other site 675635009741 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 675635009742 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 675635009743 active site 675635009744 metal binding site [ion binding]; metal-binding site 675635009745 DNA binding site [nucleotide binding] 675635009746 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 675635009747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635009748 Integrase core domain; Region: rve; cl01316 675635009749 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635009750 active site 675635009751 catalytic residues [active] 675635009752 DNA binding site [nucleotide binding] 675635009753 Int/Topo IB signature motif; other site 675635009754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635009755 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 675635009756 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635009757 active site 675635009758 DNA binding site [nucleotide binding] 675635009759 Int/Topo IB signature motif; other site 675635009760 Domain of unknown function DUF302; Region: DUF302; cl01364 675635009761 HerA helicase [Replication, recombination, and repair]; Region: COG0433 675635009762 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 675635009763 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 675635009764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635009765 FeS/SAM binding site; other site 675635009766 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 675635009767 NMT1-like family; Region: NMT1_2; cl15260 675635009768 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 675635009769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635009770 YCII-related domain; Region: YCII; cl00999 675635009771 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635009772 TIGR03086 family protein; Region: TIGR03086 675635009773 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 675635009774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635009775 dimer interface [polypeptide binding]; other site 675635009776 phosphorylation site [posttranslational modification] 675635009777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635009778 ATP binding site [chemical binding]; other site 675635009779 Mg2+ binding site [ion binding]; other site 675635009780 G-X-G motif; other site 675635009781 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635009782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635009783 active site 675635009784 phosphorylation site [posttranslational modification] 675635009785 intermolecular recognition site; other site 675635009786 dimerization interface [polypeptide binding]; other site 675635009787 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635009788 DNA binding site [nucleotide binding] 675635009789 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 675635009790 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 675635009791 Walker A/P-loop; other site 675635009792 ATP binding site [chemical binding]; other site 675635009793 Q-loop/lid; other site 675635009794 ABC transporter signature motif; other site 675635009795 Walker B; other site 675635009796 D-loop; other site 675635009797 H-loop/switch region; other site 675635009798 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 675635009799 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 675635009800 substrate binding pocket [chemical binding]; other site 675635009801 membrane-bound complex binding site; other site 675635009802 hinge residues; other site 675635009803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635009804 dimer interface [polypeptide binding]; other site 675635009805 conserved gate region; other site 675635009806 putative PBP binding loops; other site 675635009807 ABC-ATPase subunit interface; other site 675635009808 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 675635009809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635009810 dimer interface [polypeptide binding]; other site 675635009811 conserved gate region; other site 675635009812 putative PBP binding loops; other site 675635009813 ABC-ATPase subunit interface; other site 675635009814 LysE type translocator; Region: LysE; cl00565 675635009815 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 675635009816 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 675635009817 metal binding triad; other site 675635009818 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 675635009819 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 675635009820 metal binding triad; other site 675635009821 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 675635009822 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635009823 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 675635009824 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 675635009825 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 675635009826 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 675635009827 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635009828 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 675635009829 oligomerization interface [polypeptide binding]; other site 675635009830 active site 675635009831 metal binding site [ion binding]; metal-binding site 675635009832 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 675635009833 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 675635009834 putative FMN binding site [chemical binding]; other site 675635009835 RNB domain; Region: RNB; pfam00773 675635009836 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 675635009837 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 675635009838 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 675635009839 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635009840 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635009841 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635009842 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635009843 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635009844 fumarate hydratase; Provisional; Region: PRK15389 675635009845 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 675635009846 Fumarase C-terminus; Region: Fumerase_C; cl00795 675635009847 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635009848 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 675635009849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635009850 Coenzyme A binding pocket [chemical binding]; other site 675635009851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009852 CoA-ligase; Region: Ligase_CoA; cl02894 675635009853 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635009854 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 675635009855 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 675635009856 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 675635009857 Helix-turn-helix domains; Region: HTH; cl00088 675635009858 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 675635009859 FeoA domain; Region: FeoA; cl00838 675635009860 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 675635009861 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 675635009862 NAD binding site [chemical binding]; other site 675635009863 homodimer interface [polypeptide binding]; other site 675635009864 active site 675635009865 substrate binding site [chemical binding]; other site 675635009866 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 675635009867 Peptidase family M23; Region: Peptidase_M23; pfam01551 675635009868 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 675635009869 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 675635009870 dimer interface [polypeptide binding]; other site 675635009871 PYR/PP interface [polypeptide binding]; other site 675635009872 TPP binding site [chemical binding]; other site 675635009873 substrate binding site [chemical binding]; other site 675635009874 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635009875 TPP-binding site [chemical binding]; other site 675635009876 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 675635009877 acyl-CoA synthetase; Validated; Region: PRK08162 675635009878 AMP-binding enzyme; Region: AMP-binding; cl15778 675635009879 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635009880 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635009881 Lsr2; Region: Lsr2; pfam11774 675635009882 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 675635009883 classical (c) SDRs; Region: SDR_c; cd05233 675635009884 NAD(P) binding site [chemical binding]; other site 675635009885 active site 675635009886 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635009887 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635009888 catalytic residue [active] 675635009889 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 675635009890 siderophore binding site; other site 675635009891 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 675635009892 active site 675635009893 substrate binding site [chemical binding]; other site 675635009894 cosubstrate binding site; other site 675635009895 catalytic site [active] 675635009896 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 675635009897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635009898 Helix-turn-helix domains; Region: HTH; cl00088 675635009899 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635009900 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635009901 active site 675635009902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009903 NAD(P) binding site [chemical binding]; other site 675635009904 active site 675635009905 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 675635009906 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635009907 dimer interface [polypeptide binding]; other site 675635009908 active site 675635009909 Helix-turn-helix domains; Region: HTH; cl00088 675635009910 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635009911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635009912 putative substrate translocation pore; other site 675635009913 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635009914 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635009915 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635009916 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635009917 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635009918 active site 675635009919 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 675635009920 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 675635009921 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635009922 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635009923 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 675635009924 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 675635009925 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 675635009926 oxyanion hole (OAH) forming residues; other site 675635009927 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 675635009928 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635009929 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635009930 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635009931 active site 675635009932 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635009933 active site 675635009934 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635009935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635009936 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635009937 putative substrate translocation pore; other site 675635009938 Helix-turn-helix domains; Region: HTH; cl00088 675635009939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009941 active site 675635009942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009943 active site 675635009944 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 675635009945 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 675635009946 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 675635009947 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 675635009948 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 675635009949 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635009950 Family description; Region: UvrD_C_2; cl15862 675635009951 Response regulator receiver domain; Region: Response_reg; pfam00072 675635009952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635009953 active site 675635009954 phosphorylation site [posttranslational modification] 675635009955 intermolecular recognition site; other site 675635009956 dimerization interface [polypeptide binding]; other site 675635009957 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 675635009958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009960 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635009961 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635009962 ligand binding site [chemical binding]; other site 675635009963 flexible hinge region; other site 675635009964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635009965 ATP binding site [chemical binding]; other site 675635009966 Mg2+ binding site [ion binding]; other site 675635009967 G-X-G motif; other site 675635009968 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 675635009969 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 675635009970 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 675635009971 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 675635009972 homodimer interface [polypeptide binding]; other site 675635009973 NADP binding site [chemical binding]; other site 675635009974 substrate binding site [chemical binding]; other site 675635009975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635009976 putative substrate translocation pore; other site 675635009977 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 675635009978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635009979 AzlC protein; Region: AzlC; cl00570 675635009980 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635009981 Helix-turn-helix domains; Region: HTH; cl00088 675635009982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009983 NAD(P) binding site [chemical binding]; other site 675635009984 active site 675635009985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635009986 DNA-binding site [nucleotide binding]; DNA binding site 675635009987 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 675635009988 FCD domain; Region: FCD; cl11656 675635009989 Cysteine-rich domain; Region: CCG; pfam02754 675635009990 Cysteine-rich domain; Region: CCG; pfam02754 675635009991 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 675635009992 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 675635009993 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 675635009994 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 675635009995 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 675635009996 putative ADP-ribose binding site [chemical binding]; other site 675635009997 putative active site [active] 675635009998 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 675635009999 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 675635010000 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635010001 catalytic residue [active] 675635010002 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635010003 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010004 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635010005 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010006 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 675635010007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010008 putative substrate translocation pore; other site 675635010009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010010 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 675635010011 hypothetical protein; Provisional; Region: PRK06815 675635010012 tetramer interface [polypeptide binding]; other site 675635010013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635010014 catalytic residue [active] 675635010015 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 675635010016 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 675635010017 B12 binding site [chemical binding]; other site 675635010018 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 675635010019 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 675635010020 PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558 675635010021 probable active site [active] 675635010022 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 675635010023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010024 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 675635010025 Helix-turn-helix domains; Region: HTH; cl00088 675635010026 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635010027 dimerization interface [polypeptide binding]; other site 675635010028 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 675635010029 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 675635010030 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635010031 phosphate binding site [ion binding]; other site 675635010032 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635010033 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 675635010034 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 675635010035 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635010036 Helix-turn-helix domains; Region: HTH; cl00088 675635010037 WYL domain; Region: WYL; cl14852 675635010038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 675635010039 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635010040 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 675635010041 Walker A/P-loop; other site 675635010042 ATP binding site [chemical binding]; other site 675635010043 Q-loop/lid; other site 675635010044 ABC transporter signature motif; other site 675635010045 Walker B; other site 675635010046 D-loop; other site 675635010047 H-loop/switch region; other site 675635010048 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635010049 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 675635010050 Walker A/P-loop; other site 675635010051 ATP binding site [chemical binding]; other site 675635010052 Q-loop/lid; other site 675635010053 ABC transporter signature motif; other site 675635010054 Walker B; other site 675635010055 D-loop; other site 675635010056 H-loop/switch region; other site 675635010057 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 675635010058 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 675635010059 Domain of unknown function (DUF385); Region: DUF385; cl04387 675635010060 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 675635010061 metal binding site [ion binding]; metal-binding site 675635010062 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 675635010063 PLD-like domain; Region: PLDc_2; pfam13091 675635010064 putative homodimer interface [polypeptide binding]; other site 675635010065 putative active site [active] 675635010066 catalytic site [active] 675635010067 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 675635010068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635010069 nucleotide binding region [chemical binding]; other site 675635010070 ATP-binding site [chemical binding]; other site 675635010071 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 675635010072 CGNR zinc finger; Region: zf-CGNR; pfam11706 675635010073 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635010074 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635010075 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635010076 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 675635010077 Cupin domain; Region: Cupin_2; cl09118 675635010078 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635010079 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010080 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 675635010081 putative hydrophobic ligand binding site [chemical binding]; other site 675635010082 CLM binding site; other site 675635010083 DNA binding site [nucleotide binding] 675635010084 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 675635010085 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635010086 active site 675635010087 catalytic tetrad [active] 675635010088 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 675635010089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635010090 S-adenosylmethionine binding site [chemical binding]; other site 675635010091 PAS domain S-box; Region: sensory_box; TIGR00229 675635010092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635010093 putative active site [active] 675635010094 heme pocket [chemical binding]; other site 675635010095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635010096 metal binding site [ion binding]; metal-binding site 675635010097 active site 675635010098 I-site; other site 675635010099 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 675635010100 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 675635010101 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 675635010102 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635010103 classical (c) SDRs; Region: SDR_c; cd05233 675635010104 NAD(P) binding site [chemical binding]; other site 675635010105 active site 675635010106 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010107 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635010108 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 675635010109 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635010110 Walker A/P-loop; other site 675635010111 ATP binding site [chemical binding]; other site 675635010112 Q-loop/lid; other site 675635010113 ABC transporter signature motif; other site 675635010114 Walker B; other site 675635010115 D-loop; other site 675635010116 H-loop/switch region; other site 675635010117 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635010118 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 675635010119 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635010120 Walker A/P-loop; other site 675635010121 ATP binding site [chemical binding]; other site 675635010122 Q-loop/lid; other site 675635010123 ABC transporter signature motif; other site 675635010124 Walker B; other site 675635010125 D-loop; other site 675635010126 H-loop/switch region; other site 675635010127 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635010128 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635010129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635010130 dimer interface [polypeptide binding]; other site 675635010131 conserved gate region; other site 675635010132 putative PBP binding loops; other site 675635010133 ABC-ATPase subunit interface; other site 675635010134 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 675635010135 peptide binding site [polypeptide binding]; other site 675635010136 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635010137 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 675635010138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635010139 putative PBP binding loops; other site 675635010140 dimer interface [polypeptide binding]; other site 675635010141 ABC-ATPase subunit interface; other site 675635010142 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635010143 hydrophobic ligand binding site; other site 675635010144 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635010145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010146 NAD(P) binding site [chemical binding]; other site 675635010147 active site 675635010148 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 675635010149 AMP-binding enzyme; Region: AMP-binding; cl15778 675635010150 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635010151 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635010152 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635010153 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010154 transcriptional regulator BetI; Validated; Region: PRK00767 675635010155 Helix-turn-helix domains; Region: HTH; cl00088 675635010156 enoyl-CoA hydratase; Provisional; Region: PRK07799 675635010157 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635010158 substrate binding site [chemical binding]; other site 675635010159 oxyanion hole (OAH) forming residues; other site 675635010160 trimer interface [polypeptide binding]; other site 675635010161 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 675635010162 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635010163 active site 675635010164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010165 NAD(P) binding site [chemical binding]; other site 675635010166 active site 675635010167 transcription termination factor Rho; Provisional; Region: rho; PRK09376 675635010168 acyl-CoA synthetase; Validated; Region: PRK06164 675635010169 AMP-binding enzyme; Region: AMP-binding; cl15778 675635010170 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 675635010171 active site 675635010172 FMN binding site [chemical binding]; other site 675635010173 substrate binding site [chemical binding]; other site 675635010174 homotetramer interface [polypeptide binding]; other site 675635010175 catalytic residue [active] 675635010176 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 675635010177 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 675635010178 tetramer interface [polypeptide binding]; other site 675635010179 heme binding pocket [chemical binding]; other site 675635010180 NADPH binding site [chemical binding]; other site 675635010181 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 675635010182 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635010183 Helix-turn-helix domains; Region: HTH; cl00088 675635010184 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635010185 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 675635010186 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 675635010187 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635010188 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635010189 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635010190 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635010191 active site 675635010192 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 675635010193 putative active site [active] 675635010194 putative catalytic site [active] 675635010195 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635010196 active site 675635010197 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 675635010198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635010199 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 675635010200 Walker A motif; other site 675635010201 ATP binding site [chemical binding]; other site 675635010202 Walker B motif; other site 675635010203 arginine finger; other site 675635010204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635010205 Walker A motif; other site 675635010206 ATP binding site [chemical binding]; other site 675635010207 Walker B motif; other site 675635010208 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 675635010209 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 675635010210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635010211 YCII-related domain; Region: YCII; cl00999 675635010212 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 675635010213 putative hydrophobic ligand binding site [chemical binding]; other site 675635010214 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635010215 dinuclear metal binding motif [ion binding]; other site 675635010216 CCC1-related family of proteins; Region: CCC1_like; cl00278 675635010217 Transposase domain (DUF772); Region: DUF772; cl15789 675635010218 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635010219 Transposase domain (DUF772); Region: DUF772; cl15789 675635010220 glycolate transporter; Provisional; Region: PRK09695 675635010221 L-lactate permease; Region: Lactate_perm; cl00701 675635010222 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 675635010223 putative FMN binding site [chemical binding]; other site 675635010224 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 675635010225 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 675635010226 dimerization interface [polypeptide binding]; other site 675635010227 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010228 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635010229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010230 NAD(P) binding site [chemical binding]; other site 675635010231 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635010232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010233 NAD(P) binding site [chemical binding]; other site 675635010234 active site 675635010235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010236 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635010237 putative substrate translocation pore; other site 675635010238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010239 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010240 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635010241 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 675635010242 classical (c) SDRs; Region: SDR_c; cd05233 675635010243 NAD(P) binding site [chemical binding]; other site 675635010244 active site 675635010245 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635010246 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010247 GAF domain; Region: GAF_2; pfam13185 675635010248 GAF domain; Region: GAF; cl15785 675635010249 Helix-turn-helix domains; Region: HTH; cl00088 675635010250 GAF domain; Region: GAF_2; pfam13185 675635010251 GAF domain; Region: GAF; cl15785 675635010252 Helix-turn-helix domains; Region: HTH; cl00088 675635010253 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 675635010254 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635010256 Helix-turn-helix domains; Region: HTH; cl00088 675635010257 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 675635010258 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635010259 catalytic Zn binding site [ion binding]; other site 675635010260 structural Zn binding site [ion binding]; other site 675635010261 tetramer interface [polypeptide binding]; other site 675635010262 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635010263 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635010264 Helix-turn-helix domains; Region: HTH; cl00088 675635010265 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 675635010266 Predicted ATPase [General function prediction only]; Region: COG3903 675635010267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010268 hypothetical protein; Provisional; Region: PRK07588 675635010269 Double zinc ribbon; Region: DZR; pfam12773 675635010270 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635010271 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 675635010272 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 675635010273 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 675635010274 Ligand Binding Site [chemical binding]; other site 675635010275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635010276 dimer interface [polypeptide binding]; other site 675635010277 phosphorylation site [posttranslational modification] 675635010278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635010279 ATP binding site [chemical binding]; other site 675635010280 Mg2+ binding site [ion binding]; other site 675635010281 G-X-G motif; other site 675635010282 K+-transporting ATPase, c chain; Region: KdpC; cl00944 675635010283 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 675635010284 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635010285 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635010286 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 675635010287 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 675635010288 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635010289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635010290 DNA-binding site [nucleotide binding]; DNA binding site 675635010291 FCD domain; Region: FCD; cl11656 675635010292 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635010293 Amidase; Region: Amidase; cl11426 675635010294 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635010295 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635010296 phenylhydantoinase; Validated; Region: PRK08323 675635010297 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635010298 active site 675635010299 Isochorismatase family; Region: Isochorismatase; pfam00857 675635010300 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 675635010301 catalytic triad [active] 675635010302 conserved cis-peptide bond; other site 675635010303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010304 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635010305 NAD(P) binding site [chemical binding]; other site 675635010306 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 675635010307 active site 675635010308 catalytic residues [active] 675635010309 metal binding site [ion binding]; metal-binding site 675635010310 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 675635010311 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635010312 active site 675635010313 catalytic tetrad [active] 675635010314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010315 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635010316 TM-ABC transporter signature motif; other site 675635010317 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635010318 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 675635010319 Walker A/P-loop; other site 675635010320 ATP binding site [chemical binding]; other site 675635010321 Q-loop/lid; other site 675635010322 ABC transporter signature motif; other site 675635010323 Walker B; other site 675635010324 D-loop; other site 675635010325 H-loop/switch region; other site 675635010326 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 675635010327 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635010328 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635010329 ligand binding site [chemical binding]; other site 675635010330 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635010331 phenylhydantoinase; Validated; Region: PRK08323 675635010332 active site 675635010333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635010334 DNA-binding site [nucleotide binding]; DNA binding site 675635010335 FCD domain; Region: FCD; cl11656 675635010336 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 675635010337 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 675635010338 active site 675635010339 catalytic site [active] 675635010340 tetramer interface [polypeptide binding]; other site 675635010341 Cupin domain; Region: Cupin_2; cl09118 675635010342 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010343 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 675635010344 Dehydratase family; Region: ILVD_EDD; cl00340 675635010345 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635010346 TM-ABC transporter signature motif; other site 675635010347 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635010348 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635010349 Walker A/P-loop; other site 675635010350 ATP binding site [chemical binding]; other site 675635010351 Q-loop/lid; other site 675635010352 ABC transporter signature motif; other site 675635010353 Walker B; other site 675635010354 D-loop; other site 675635010355 H-loop/switch region; other site 675635010356 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 675635010357 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635010358 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635010359 ligand binding site [chemical binding]; other site 675635010360 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 675635010361 Isochorismatase family; Region: Isochorismatase; pfam00857 675635010362 catalytic triad [active] 675635010363 conserved cis-peptide bond; other site 675635010364 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635010365 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635010366 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 675635010367 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 675635010368 active site 675635010369 catalytic site [active] 675635010370 tetramer interface [polypeptide binding]; other site 675635010371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635010372 DNA-binding site [nucleotide binding]; DNA binding site 675635010373 FCD domain; Region: FCD; cl11656 675635010374 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635010375 Helix-turn-helix domains; Region: HTH; cl00088 675635010376 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635010377 acetaldehyde dehydrogenase; Validated; Region: PRK08300 675635010378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010379 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 675635010380 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 675635010381 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 675635010382 active site 675635010383 catalytic residues [active] 675635010384 metal binding site [ion binding]; metal-binding site 675635010385 DmpG-like communication domain; Region: DmpG_comm; pfam07836 675635010386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010387 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010388 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 675635010389 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 675635010390 metal binding site [ion binding]; metal-binding site 675635010391 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 675635010392 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635010393 phosphate binding site [ion binding]; other site 675635010394 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 675635010395 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635010396 Helix-turn-helix domains; Region: HTH; cl00088 675635010397 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635010398 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 675635010399 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635010400 phosphate binding site [ion binding]; other site 675635010401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635010402 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 675635010403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635010404 S-adenosylmethionine binding site [chemical binding]; other site 675635010405 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635010406 NMT1/THI5 like; Region: NMT1; pfam09084 675635010407 NMT1-like family; Region: NMT1_2; cl15260 675635010408 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 675635010409 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 675635010410 Walker A/P-loop; other site 675635010411 ATP binding site [chemical binding]; other site 675635010412 Q-loop/lid; other site 675635010413 ABC transporter signature motif; other site 675635010414 Walker B; other site 675635010415 D-loop; other site 675635010416 H-loop/switch region; other site 675635010417 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 675635010418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635010419 dimer interface [polypeptide binding]; other site 675635010420 conserved gate region; other site 675635010421 putative PBP binding loops; other site 675635010422 ABC-ATPase subunit interface; other site 675635010423 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635010424 classical (c) SDRs; Region: SDR_c; cd05233 675635010425 NAD(P) binding site [chemical binding]; other site 675635010426 active site 675635010427 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 675635010428 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 675635010429 metal binding site [ion binding]; metal-binding site 675635010430 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010431 OsmC-like protein; Region: OsmC; cl00767 675635010432 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635010433 Helix-turn-helix domains; Region: HTH; cl00088 675635010434 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635010435 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635010436 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635010437 Putative cyclase; Region: Cyclase; cl00814 675635010438 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 675635010439 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 675635010440 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635010441 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635010442 active site 675635010443 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 675635010444 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635010445 anti sigma factor interaction site; other site 675635010446 regulatory phosphorylation site [posttranslational modification]; other site 675635010447 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635010448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635010449 active site 675635010450 metal binding site [ion binding]; metal-binding site 675635010451 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 675635010452 FMN binding site [chemical binding]; other site 675635010453 dimer interface [polypeptide binding]; other site 675635010454 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 675635010455 [2Fe-2S] cluster binding site [ion binding]; other site 675635010456 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 675635010457 [2Fe-2S] cluster binding site [ion binding]; other site 675635010458 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635010459 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635010460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635010461 Helix-turn-helix domains; Region: HTH; cl00088 675635010462 WHG domain; Region: WHG; pfam13305 675635010463 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635010464 active site 675635010465 nucleotide binding site [chemical binding]; other site 675635010466 HIGH motif; other site 675635010467 KMSKS motif; other site 675635010468 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010469 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635010470 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635010471 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635010472 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 675635010473 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 675635010474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010475 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 675635010476 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635010477 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635010478 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010479 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635010480 AMP-binding enzyme; Region: AMP-binding; cl15778 675635010481 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635010482 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635010483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010484 Helix-turn-helix domains; Region: HTH; cl00088 675635010485 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 675635010486 hydrophobic ligand binding site; other site 675635010487 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635010488 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 675635010489 Protein of unknown function (DUF421); Region: DUF421; cl00990 675635010490 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 675635010491 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 675635010492 molybdopterin cofactor binding site; other site 675635010493 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 675635010494 molybdopterin cofactor binding site; other site 675635010495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010496 active site 675635010497 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 675635010498 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635010499 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635010500 active site 675635010501 ATP binding site [chemical binding]; other site 675635010502 substrate binding site [chemical binding]; other site 675635010503 activation loop (A-loop); other site 675635010504 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 675635010505 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635010506 P-loop; other site 675635010507 Magnesium ion binding site [ion binding]; other site 675635010508 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635010509 Magnesium ion binding site [ion binding]; other site 675635010510 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 675635010511 GAF domain; Region: GAF; cl15785 675635010512 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 675635010513 Gas vesicle protein; Region: Gas_vesicle; cl02954 675635010514 Domain of unknown function (DUF336); Region: DUF336; cl01249 675635010515 PaaX-like protein; Region: PaaX; pfam07848 675635010516 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 675635010517 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 675635010518 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635010519 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010520 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635010521 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 675635010522 AMP-binding enzyme; Region: AMP-binding; cl15778 675635010523 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635010524 Predicted amidohydrolase [General function prediction only]; Region: COG0388 675635010525 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 675635010526 putative active site [active] 675635010527 catalytic triad [active] 675635010528 putative dimer interface [polypeptide binding]; other site 675635010529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010530 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 675635010531 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635010532 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635010533 phosphate binding site [ion binding]; other site 675635010534 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 675635010535 Cupin domain; Region: Cupin_2; cl09118 675635010536 Cupin domain; Region: Cupin_2; cl09118 675635010537 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635010538 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635010539 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 675635010540 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 675635010541 active site 675635010542 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 675635010543 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 675635010544 active site 675635010545 metal binding site [ion binding]; metal-binding site 675635010546 dimer interface [polypeptide binding]; other site 675635010547 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 675635010548 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635010549 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635010550 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635010551 DNA binding residues [nucleotide binding] 675635010552 dimerization interface [polypeptide binding]; other site 675635010553 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635010554 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635010555 DNA binding residues [nucleotide binding] 675635010556 dimerization interface [polypeptide binding]; other site 675635010557 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 675635010558 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 675635010559 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 675635010560 RDD family; Region: RDD; cl00746 675635010561 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 675635010562 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 675635010563 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 675635010564 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635010565 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 675635010566 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635010567 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 675635010568 high affinity sulphate transporter 1; Region: sulP; TIGR00815 675635010569 Sulfate transporter family; Region: Sulfate_transp; cl15842 675635010570 Sulfate transporter family; Region: Sulfate_transp; cl15842 675635010571 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 675635010572 Transposase domain (DUF772); Region: DUF772; cl15789 675635010573 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635010574 Transposase domain (DUF772); Region: DUF772; cl15789 675635010575 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 675635010576 Ion channel; Region: Ion_trans_2; cl11596 675635010577 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 675635010578 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635010579 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635010580 DNA binding residues [nucleotide binding] 675635010581 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 675635010582 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 675635010583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010584 putative substrate translocation pore; other site 675635010585 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 675635010586 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 675635010587 dimer interface [polypeptide binding]; other site 675635010588 NADP binding site [chemical binding]; other site 675635010589 catalytic residues [active] 675635010590 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 675635010591 4Fe-4S binding domain; Region: Fer4; cl02805 675635010592 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 675635010593 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 675635010594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010595 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 675635010596 active site 675635010597 metal binding site [ion binding]; metal-binding site 675635010598 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635010599 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635010600 Helix-turn-helix domains; Region: HTH; cl00088 675635010601 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635010602 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 675635010603 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 675635010604 [2Fe-2S] cluster binding site [ion binding]; other site 675635010605 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635010606 hydrophobic ligand binding site; other site 675635010607 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 675635010608 inter-subunit interface; other site 675635010609 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635010610 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010611 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 675635010612 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635010613 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635010614 Protein of unknown function (DUF421); Region: DUF421; cl00990 675635010615 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010616 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635010617 Helix-turn-helix domains; Region: HTH; cl00088 675635010618 putative transcriptional regulator; Provisional; Region: PRK11640 675635010619 Hedgehog amino-terminal signalling domain; Region: HH_signal; pfam01085 675635010620 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635010621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010622 putative substrate translocation pore; other site 675635010623 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 675635010624 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 675635010625 [4Fe-4S] binding site [ion binding]; other site 675635010626 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635010627 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635010628 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635010629 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 675635010630 molybdopterin cofactor binding site; other site 675635010631 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 675635010632 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 675635010633 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 675635010634 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635010635 Transposase domain (DUF772); Region: DUF772; cl15789 675635010636 Phosphoesterase family; Region: Phosphoesterase; cl15450 675635010637 Phosphoesterase family; Region: Phosphoesterase; cl15450 675635010638 haloalkane dehalogenase; Provisional; Region: PRK03592 675635010639 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635010640 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 675635010641 metal binding site [ion binding]; metal-binding site 675635010642 substrate binding pocket [chemical binding]; other site 675635010643 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 675635010644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010645 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 675635010646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635010647 Helix-turn-helix domains; Region: HTH; cl00088 675635010648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635010649 Predicted ATPase [General function prediction only]; Region: COG3899 675635010650 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635010651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635010652 DNA binding residues [nucleotide binding] 675635010653 dimerization interface [polypeptide binding]; other site 675635010654 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 675635010655 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 675635010656 Predicted ATPase [General function prediction only]; Region: COG3899 675635010657 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635010658 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 675635010659 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635010660 DNA binding residues [nucleotide binding] 675635010661 dimerization interface [polypeptide binding]; other site 675635010662 short chain dehydrogenase; Provisional; Region: PRK07041 675635010663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010664 NAD(P) binding site [chemical binding]; other site 675635010665 active site 675635010666 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 675635010667 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635010668 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635010669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 675635010670 MOSC domain; Region: MOSC; pfam03473 675635010671 3-alpha domain; Region: 3-alpha; pfam03475 675635010672 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 675635010673 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 675635010674 FAD binding pocket [chemical binding]; other site 675635010675 FAD binding motif [chemical binding]; other site 675635010676 phosphate binding motif [ion binding]; other site 675635010677 beta-alpha-beta structure motif; other site 675635010678 NAD binding pocket [chemical binding]; other site 675635010679 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635010680 catalytic loop [active] 675635010681 iron binding site [ion binding]; other site 675635010682 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010683 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 675635010684 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 675635010685 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 675635010686 Zn2+ binding site [ion binding]; other site 675635010687 Mg2+ binding site [ion binding]; other site 675635010688 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635010689 DNA binding residues [nucleotide binding] 675635010690 dimerization interface [polypeptide binding]; other site 675635010691 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 675635010692 hypothetical protein; Provisional; Region: PRK06153 675635010693 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 675635010694 ATP binding site [chemical binding]; other site 675635010695 substrate interface [chemical binding]; other site 675635010696 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635010697 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635010698 Arginase family; Region: Arginase; cl00306 675635010699 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 675635010700 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 675635010701 TOBE domain; Region: TOBE_2; cl01440 675635010702 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 675635010703 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635010704 putative DNA binding site [nucleotide binding]; other site 675635010705 putative Zn2+ binding site [ion binding]; other site 675635010706 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 675635010707 putative hydrophobic ligand binding site [chemical binding]; other site 675635010708 CLM binding site; other site 675635010709 L1 loop; other site 675635010710 DNA binding site [nucleotide binding] 675635010711 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635010712 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635010713 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635010714 active site 675635010715 substrate binding site [chemical binding]; other site 675635010716 ATP binding site [chemical binding]; other site 675635010717 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 675635010718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635010720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010721 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635010722 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635010723 active site residue [active] 675635010724 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635010725 active site residue [active] 675635010726 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635010727 dimerization interface [polypeptide binding]; other site 675635010728 putative DNA binding site [nucleotide binding]; other site 675635010729 putative Zn2+ binding site [ion binding]; other site 675635010730 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635010731 active site residue [active] 675635010732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010733 H+ Antiporter protein; Region: 2A0121; TIGR00900 675635010734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010735 putative substrate translocation pore; other site 675635010736 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 675635010737 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635010738 metal-binding site [ion binding] 675635010739 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635010740 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 675635010741 catalytic residues [active] 675635010742 Vitamin K epoxide reductase family; Region: VKOR; cl01729 675635010743 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635010744 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 675635010745 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 675635010746 Peptidase family M23; Region: Peptidase_M23; pfam01551 675635010747 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 675635010748 Bacterial Ig-like domain; Region: Big_5; cl01012 675635010749 Lsr2; Region: Lsr2; pfam11774 675635010750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010751 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 675635010752 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 675635010753 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 675635010754 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635010755 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635010756 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635010757 dimerization interface [polypeptide binding]; other site 675635010758 putative DNA binding site [nucleotide binding]; other site 675635010759 putative Zn2+ binding site [ion binding]; other site 675635010760 Cation efflux family; Region: Cation_efflux; cl00316 675635010761 TrwC relaxase; Region: TrwC; pfam08751 675635010762 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 675635010763 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 675635010764 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635010765 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635010766 Walker A motif; other site 675635010767 ATP binding site [chemical binding]; other site 675635010768 Walker B motif; other site 675635010769 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635010770 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 675635010771 dimer interface [polypeptide binding]; other site 675635010772 ADP-ribose binding site [chemical binding]; other site 675635010773 active site 675635010774 nudix motif; other site 675635010775 metal binding site [ion binding]; metal-binding site 675635010776 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635010777 DNA-binding site [nucleotide binding]; DNA binding site 675635010778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635010779 DNA-binding site [nucleotide binding]; DNA binding site 675635010780 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 675635010781 Int/Topo IB signature motif; other site 675635010782 Helix-turn-helix domains; Region: HTH; cl00088 675635010783 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635010784 Protein of unknown function (DUF419); Region: DUF419; cl15265 675635010785 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 675635010786 putative hydrophobic ligand binding site [chemical binding]; other site 675635010787 protein interface [polypeptide binding]; other site 675635010788 gate; other site 675635010789 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 675635010790 Uncharacterized protein family (UPF0261); Region: UPF0261; cl02262 675635010791 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 675635010792 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 675635010793 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 675635010794 putative active site [active] 675635010795 putative metal binding site [ion binding]; other site 675635010796 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 675635010797 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 675635010798 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635010799 tetracycline repressor protein TetR; Provisional; Region: PRK13756 675635010800 Helix-turn-helix domains; Region: HTH; cl00088 675635010801 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 675635010802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010803 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635010804 putative substrate translocation pore; other site 675635010805 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635010806 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635010807 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 675635010808 B12 binding site [chemical binding]; other site 675635010809 cobalt ligand [ion binding]; other site 675635010810 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 675635010811 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635010812 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 675635010813 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 675635010814 Helix-turn-helix domains; Region: HTH; cl00088 675635010815 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 675635010816 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 675635010817 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 675635010818 intersubunit interface [polypeptide binding]; other site 675635010819 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 675635010820 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635010821 substrate binding site [chemical binding]; other site 675635010822 oxyanion hole (OAH) forming residues; other site 675635010823 trimer interface [polypeptide binding]; other site 675635010824 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 675635010825 Transposase domain (DUF772); Region: DUF772; cl15789 675635010826 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635010827 Transposase domain (DUF772); Region: DUF772; cl15789 675635010828 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 675635010829 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 675635010830 catalytic residue [active] 675635010831 Helix-turn-helix domains; Region: HTH; cl00088 675635010832 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 675635010833 FAD binding domain; Region: FAD_binding_4; pfam01565 675635010834 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 675635010835 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635010836 nudix motif; other site 675635010837 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 675635010838 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635010839 Helix-turn-helix domains; Region: HTH; cl00088 675635010840 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 675635010841 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 675635010842 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 675635010843 [2Fe-2S] cluster binding site [ion binding]; other site 675635010844 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 675635010845 putative alpha subunit interface [polypeptide binding]; other site 675635010846 putative active site [active] 675635010847 putative substrate binding site [chemical binding]; other site 675635010848 Fe binding site [ion binding]; other site 675635010849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635010851 S-adenosylmethionine binding site [chemical binding]; other site 675635010852 Cupin domain; Region: Cupin_2; cl09118 675635010853 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635010854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635010855 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635010856 Helix-turn-helix domains; Region: HTH; cl00088 675635010857 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635010858 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635010859 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635010860 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 675635010861 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635010862 active site 675635010863 catalytic tetrad [active] 675635010864 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635010865 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010866 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010867 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 675635010868 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 675635010869 putative hydrophobic ligand binding site [chemical binding]; other site 675635010870 FAD binding domain; Region: FAD_binding_3; pfam01494 675635010871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010873 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 675635010874 salicylate hydroxylase; Provisional; Region: PRK06475 675635010875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010876 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 675635010877 active site 675635010878 NAD binding site [chemical binding]; other site 675635010879 metal binding site [ion binding]; metal-binding site 675635010880 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 675635010881 active site 675635010882 NAD binding site [chemical binding]; other site 675635010883 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635010884 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635010885 active site 675635010886 metal binding site [ion binding]; metal-binding site 675635010887 Helix-turn-helix domains; Region: HTH; cl00088 675635010888 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010889 Helix-turn-helix domains; Region: HTH; cl00088 675635010890 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 675635010891 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 675635010892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635010893 S-adenosylmethionine binding site [chemical binding]; other site 675635010894 DNA primase; Validated; Region: dnaG; PRK05667 675635010895 CHC2 zinc finger; Region: zf-CHC2; cl15369 675635010896 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 675635010897 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 675635010898 active site 675635010899 metal binding site [ion binding]; metal-binding site 675635010900 interdomain interaction site; other site 675635010901 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 675635010902 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 675635010903 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635010904 active site 675635010905 metal binding site [ion binding]; metal-binding site 675635010906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010907 NADH(P)-binding; Region: NAD_binding_10; pfam13460 675635010908 NAD(P) binding site [chemical binding]; other site 675635010909 active site 675635010910 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 675635010911 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635010912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635010913 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635010914 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635010915 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 675635010916 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 675635010917 Zn2+ binding site [ion binding]; other site 675635010918 Mg2+ binding site [ion binding]; other site 675635010919 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 675635010920 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 675635010921 putative active site [active] 675635010922 XdhC Rossmann domain; Region: XdhC_C; pfam13478 675635010923 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635010924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635010925 active site 675635010926 phosphorylation site [posttranslational modification] 675635010927 intermolecular recognition site; other site 675635010928 dimerization interface [polypeptide binding]; other site 675635010929 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635010930 DNA binding residues [nucleotide binding] 675635010931 dimerization interface [polypeptide binding]; other site 675635010932 Histidine kinase; Region: HisKA_3; pfam07730 675635010933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635010934 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 675635010935 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 675635010936 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 675635010937 Walker A/P-loop; other site 675635010938 ATP binding site [chemical binding]; other site 675635010939 Q-loop/lid; other site 675635010940 ABC transporter signature motif; other site 675635010941 Walker B; other site 675635010942 D-loop; other site 675635010943 H-loop/switch region; other site 675635010944 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 675635010945 Domain of unknown function DUF21; Region: DUF21; pfam01595 675635010946 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 675635010947 Transporter associated domain; Region: CorC_HlyC; cl08393 675635010948 Domain of unknown function DUF21; Region: DUF21; pfam01595 675635010949 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 675635010950 glycyl-tRNA synthetase; Provisional; Region: PRK04173 675635010951 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 675635010952 motif 1; other site 675635010953 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 675635010954 active site 675635010955 motif 2; other site 675635010956 motif 3; other site 675635010957 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 675635010958 anticodon binding site; other site 675635010959 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635010960 dimerization interface [polypeptide binding]; other site 675635010961 putative DNA binding site [nucleotide binding]; other site 675635010962 putative Zn2+ binding site [ion binding]; other site 675635010963 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 675635010964 putative hydrophobic ligand binding site [chemical binding]; other site 675635010965 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 675635010966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635010967 putative DNA binding site [nucleotide binding]; other site 675635010968 putative Zn2+ binding site [ion binding]; other site 675635010969 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 675635010970 metal binding site 2 [ion binding]; metal-binding site 675635010971 putative DNA binding helix; other site 675635010972 metal binding site 1 [ion binding]; metal-binding site 675635010973 dimer interface [polypeptide binding]; other site 675635010974 structural Zn2+ binding site [ion binding]; other site 675635010975 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 675635010976 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 675635010977 catalytic residue [active] 675635010978 putative FPP diphosphate binding site; other site 675635010979 putative FPP binding hydrophobic cleft; other site 675635010980 dimer interface [polypeptide binding]; other site 675635010981 putative IPP diphosphate binding site; other site 675635010982 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 675635010983 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 675635010984 Recombination protein O N terminal; Region: RecO_N; cl15812 675635010985 Recombination protein O C terminal; Region: RecO_C; pfam02565 675635010986 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635010987 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 675635010988 GTPase Era; Reviewed; Region: era; PRK00089 675635010989 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 675635010990 G1 box; other site 675635010991 GTP/Mg2+ binding site [chemical binding]; other site 675635010992 Switch I region; other site 675635010993 G2 box; other site 675635010994 Switch II region; other site 675635010995 G3 box; other site 675635010996 G4 box; other site 675635010997 G5 box; other site 675635010998 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 675635010999 hydroxyglutarate oxidase; Provisional; Region: PRK11728 675635011000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011001 Domain of unknown function DUF21; Region: DUF21; pfam01595 675635011002 FOG: CBS domain [General function prediction only]; Region: COG0517 675635011003 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 675635011004 Transporter associated domain; Region: CorC_HlyC; cl08393 675635011005 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 675635011006 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 675635011007 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635011008 Isochorismatase family; Region: Isochorismatase; pfam00857 675635011009 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 675635011010 catalytic triad [active] 675635011011 dimer interface [polypeptide binding]; other site 675635011012 conserved cis-peptide bond; other site 675635011013 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 675635011014 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635011015 PYR/PP interface [polypeptide binding]; other site 675635011016 dimer interface [polypeptide binding]; other site 675635011017 TPP binding site [chemical binding]; other site 675635011018 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 675635011019 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 675635011020 TPP-binding site [chemical binding]; other site 675635011021 Putative cyclase; Region: Cyclase; cl00814 675635011022 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635011023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 675635011024 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 675635011025 chaperone protein DnaJ; Provisional; Region: PRK14278 675635011026 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 675635011027 HSP70 interaction site [polypeptide binding]; other site 675635011028 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 675635011029 Zn binding sites [ion binding]; other site 675635011030 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 675635011031 dimer interface [polypeptide binding]; other site 675635011032 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 675635011033 Helix-turn-helix domains; Region: HTH; cl00088 675635011034 HrcA protein C terminal domain; Region: HrcA; pfam01628 675635011035 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 675635011036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635011037 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 675635011038 Walker A/P-loop; other site 675635011039 ATP binding site [chemical binding]; other site 675635011040 Q-loop/lid; other site 675635011041 ABC transporter signature motif; other site 675635011042 Walker B; other site 675635011043 D-loop; other site 675635011044 H-loop/switch region; other site 675635011045 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 675635011046 coproporphyrinogen III oxidase; Validated; Region: PRK05628 675635011047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635011048 FeS/SAM binding site; other site 675635011049 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 675635011050 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 675635011051 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 675635011052 FtsX-like permease family; Region: FtsX; cl15850 675635011053 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 675635011054 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 675635011055 Walker A/P-loop; other site 675635011056 ATP binding site [chemical binding]; other site 675635011057 Q-loop/lid; other site 675635011058 ABC transporter signature motif; other site 675635011059 Walker B; other site 675635011060 D-loop; other site 675635011061 H-loop/switch region; other site 675635011062 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 675635011063 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 675635011064 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 675635011065 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 675635011066 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 675635011067 Active Sites [active] 675635011068 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 675635011069 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 675635011070 Active Sites [active] 675635011071 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 675635011072 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 675635011073 CysD dimerization site [polypeptide binding]; other site 675635011074 G1 box; other site 675635011075 putative GEF interaction site [polypeptide binding]; other site 675635011076 GTP/Mg2+ binding site [chemical binding]; other site 675635011077 Switch I region; other site 675635011078 G2 box; other site 675635011079 G3 box; other site 675635011080 Switch II region; other site 675635011081 G4 box; other site 675635011082 G5 box; other site 675635011083 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 675635011084 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 675635011085 NMT1-like family; Region: NMT1_2; cl15260 675635011086 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 675635011087 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 675635011088 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 675635011089 Walker A/P-loop; other site 675635011090 ATP binding site [chemical binding]; other site 675635011091 Q-loop/lid; other site 675635011092 ABC transporter signature motif; other site 675635011093 Walker B; other site 675635011094 D-loop; other site 675635011095 H-loop/switch region; other site 675635011096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635011097 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 675635011098 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 675635011099 putative active site [active] 675635011100 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 675635011101 putative active site [active] 675635011102 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635011103 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 675635011104 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635011105 Walker A/P-loop; other site 675635011106 ATP binding site [chemical binding]; other site 675635011107 Q-loop/lid; other site 675635011108 ABC transporter signature motif; other site 675635011109 Walker B; other site 675635011110 D-loop; other site 675635011111 H-loop/switch region; other site 675635011112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011113 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635011114 active site 675635011115 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 675635011116 dimer interface [polypeptide binding]; other site 675635011117 non-prolyl cis peptide bond; other site 675635011118 insertion regions; other site 675635011119 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 675635011120 CoenzymeA binding site [chemical binding]; other site 675635011121 subunit interaction site [polypeptide binding]; other site 675635011122 PHB binding site; other site 675635011123 enoyl-CoA hydratase; Provisional; Region: PRK07827 675635011124 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635011125 substrate binding site [chemical binding]; other site 675635011126 oxyanion hole (OAH) forming residues; other site 675635011127 trimer interface [polypeptide binding]; other site 675635011128 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 675635011129 TIGR03086 family protein; Region: TIGR03086 675635011130 NAD-dependent deacetylase; Provisional; Region: PRK05333 675635011131 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 675635011132 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 675635011133 putative RNAase interaction site [polypeptide binding]; other site 675635011134 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 675635011135 active site 675635011136 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635011137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011138 NAD(P) binding site [chemical binding]; other site 675635011139 GTP-binding protein LepA; Provisional; Region: PRK05433 675635011140 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 675635011141 G1 box; other site 675635011142 putative GEF interaction site [polypeptide binding]; other site 675635011143 GTP/Mg2+ binding site [chemical binding]; other site 675635011144 Switch I region; other site 675635011145 G2 box; other site 675635011146 G3 box; other site 675635011147 Switch II region; other site 675635011148 G4 box; other site 675635011149 G5 box; other site 675635011150 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 675635011151 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 675635011152 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 675635011153 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 675635011154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 675635011155 NlpC/P60 family; Region: NLPC_P60; cl11438 675635011156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 675635011157 phosphorylation site [posttranslational modification] 675635011158 intermolecular recognition site; other site 675635011159 transcriptional regulator NarP; Provisional; Region: PRK10403 675635011160 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635011161 DNA binding residues [nucleotide binding] 675635011162 dimerization interface [polypeptide binding]; other site 675635011163 Putative sensor; Region: Sensor; pfam13796 675635011164 Histidine kinase; Region: HisKA_3; pfam07730 675635011165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635011166 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 675635011167 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635011168 enoyl-CoA hydratase; Provisional; Region: PRK06688 675635011169 substrate binding site [chemical binding]; other site 675635011170 oxyanion hole (OAH) forming residues; other site 675635011171 trimer interface [polypeptide binding]; other site 675635011172 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 675635011173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635011174 S-adenosylmethionine binding site [chemical binding]; other site 675635011175 Cupin domain; Region: Cupin_2; cl09118 675635011176 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635011177 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 675635011178 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635011179 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635011180 active site 675635011181 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 675635011182 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 675635011183 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 675635011184 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 675635011185 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 675635011186 dimer interface [polypeptide binding]; other site 675635011187 active site 675635011188 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 675635011189 Ligand Binding Site [chemical binding]; other site 675635011190 Molecular Tunnel; other site 675635011191 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 675635011192 Di-iron ligands [ion binding]; other site 675635011193 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 675635011194 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 675635011195 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 675635011196 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635011197 FAD binding domain; Region: FAD_binding_4; pfam01565 675635011198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635011199 Helix-turn-helix domains; Region: HTH; cl00088 675635011200 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 675635011201 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 675635011202 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 675635011203 substrate binding site [chemical binding]; other site 675635011204 ATP binding site [chemical binding]; other site 675635011205 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 675635011206 Glycerate kinase family; Region: Gly_kinase; cl00841 675635011207 Glycerate kinase family; Region: Gly_kinase; cl00841 675635011208 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 675635011209 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 675635011210 homotrimer interface [polypeptide binding]; other site 675635011211 Walker A motif; other site 675635011212 GTP binding site [chemical binding]; other site 675635011213 Walker B motif; other site 675635011214 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 675635011215 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 675635011216 active site pocket [active] 675635011217 putative cataytic base [active] 675635011218 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 675635011219 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 675635011220 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 675635011221 homodimer interface [polypeptide binding]; other site 675635011222 substrate-cofactor binding pocket; other site 675635011223 catalytic residue [active] 675635011224 amino acid transporter; Region: 2A0306; TIGR00909 675635011225 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 675635011226 interface (dimer of trimers) [polypeptide binding]; other site 675635011227 Substrate-binding/catalytic site; other site 675635011228 Zn-binding sites [ion binding]; other site 675635011229 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 675635011230 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635011231 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635011232 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635011233 E3 interaction surface; other site 675635011234 lipoyl attachment site [posttranslational modification]; other site 675635011235 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635011236 E3 interaction surface; other site 675635011237 lipoyl attachment site [posttranslational modification]; other site 675635011238 e3 binding domain; Region: E3_binding; pfam02817 675635011239 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 675635011240 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 675635011241 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 675635011242 TIGR01777 family protein; Region: yfcH 675635011243 putative NAD(P) binding site [chemical binding]; other site 675635011244 putative active site [active] 675635011245 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 675635011246 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 675635011247 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635011248 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635011249 lipoyl synthase; Provisional; Region: PRK05481 675635011250 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635011251 FeS/SAM binding site; other site 675635011252 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 675635011253 RDD family; Region: RDD; cl00746 675635011254 glutamine synthetase, type I; Region: GlnA; TIGR00653 675635011255 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 675635011256 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 675635011257 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 675635011258 tetracycline repressor protein TetR; Provisional; Region: PRK13756 675635011259 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 675635011260 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 675635011261 DNA-binding site [nucleotide binding]; DNA binding site 675635011262 RNA-binding motif; other site 675635011263 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 675635011264 Di-iron ligands [ion binding]; other site 675635011265 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 675635011266 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 675635011267 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 675635011268 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 675635011269 pyruvate phosphate dikinase; Provisional; Region: PRK09279 675635011270 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 675635011271 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 675635011272 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 675635011273 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 675635011274 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635011275 Domain of unknown function (DUF385); Region: DUF385; cl04387 675635011276 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 675635011277 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 675635011278 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635011279 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 675635011280 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635011281 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 675635011282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011283 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 675635011284 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 675635011285 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635011286 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 675635011287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011288 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 675635011289 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 675635011290 putative Iron-sulfur protein interface [polypeptide binding]; other site 675635011291 proximal heme binding site [chemical binding]; other site 675635011292 distal heme binding site [chemical binding]; other site 675635011293 putative dimer interface [polypeptide binding]; other site 675635011294 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 675635011295 Helix-turn-helix domains; Region: HTH; cl00088 675635011296 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 675635011297 dimerization interface [polypeptide binding]; other site 675635011298 RecX family; Region: RecX; cl00936 675635011299 recombinase A; Provisional; Region: recA; PRK09354 675635011300 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 675635011301 hexamer interface [polypeptide binding]; other site 675635011302 Walker A motif; other site 675635011303 ATP binding site [chemical binding]; other site 675635011304 Walker B motif; other site 675635011305 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 675635011306 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635011307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635011308 Helix-turn-helix domains; Region: HTH; cl00088 675635011309 EamA-like transporter family; Region: EamA; cl01037 675635011310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635011311 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 675635011312 ATP binding site [chemical binding]; other site 675635011313 putative Mg++ binding site [ion binding]; other site 675635011314 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635011315 nucleotide binding region [chemical binding]; other site 675635011316 ATP-binding site [chemical binding]; other site 675635011317 DEAD/H associated; Region: DEAD_assoc; pfam08494 675635011318 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 675635011319 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 675635011320 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 675635011321 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 675635011322 AMP-binding enzyme; Region: AMP-binding; cl15778 675635011323 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 675635011324 Helix-turn-helix domains; Region: HTH; cl00088 675635011325 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 675635011326 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 675635011327 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635011328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635011329 active site 675635011330 phosphorylation site [posttranslational modification] 675635011331 intermolecular recognition site; other site 675635011332 dimerization interface [polypeptide binding]; other site 675635011333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635011334 DNA binding residues [nucleotide binding] 675635011335 dimerization interface [polypeptide binding]; other site 675635011336 Histidine kinase; Region: HisKA_3; pfam07730 675635011337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635011338 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 675635011339 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 675635011340 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 675635011341 Walker A/P-loop; other site 675635011342 ATP binding site [chemical binding]; other site 675635011343 Q-loop/lid; other site 675635011344 ABC transporter signature motif; other site 675635011345 Walker B; other site 675635011346 D-loop; other site 675635011347 H-loop/switch region; other site 675635011348 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 675635011349 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 675635011350 putative DNA binding site [nucleotide binding]; other site 675635011351 catalytic residue [active] 675635011352 putative H2TH interface [polypeptide binding]; other site 675635011353 putative catalytic residues [active] 675635011354 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 675635011355 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 675635011356 PspA/IM30 family; Region: PspA_IM30; pfam04012 675635011357 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635011358 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 675635011359 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 675635011360 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 675635011361 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 675635011362 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635011363 FeS/SAM binding site; other site 675635011364 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 675635011365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635011366 Coenzyme A binding pocket [chemical binding]; other site 675635011367 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635011368 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 675635011369 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635011370 YceI-like domain; Region: YceI; cl01001 675635011371 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635011372 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 675635011373 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 675635011374 Ferredoxin [Energy production and conversion]; Region: COG1146 675635011375 4Fe-4S binding domain; Region: Fer4; cl02805 675635011376 Helix-turn-helix domains; Region: HTH; cl00088 675635011377 Predicted transcriptional regulator [Transcription]; Region: COG2345 675635011378 Transposase domain (DUF772); Region: DUF772; cl15789 675635011379 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635011380 Transposase domain (DUF772); Region: DUF772; cl15789 675635011381 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 675635011382 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 675635011383 tetramer interface [polypeptide binding]; other site 675635011384 active site 675635011385 Mg2+/Mn2+ binding site [ion binding]; other site 675635011386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635011387 DNA-binding site [nucleotide binding]; DNA binding site 675635011388 FCD domain; Region: FCD; cl11656 675635011389 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635011390 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635011391 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 675635011392 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635011393 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 675635011394 catalytic triad [active] 675635011395 conserved cis-peptide bond; other site 675635011396 DNA topoisomerase III; Provisional; Region: PRK14724 675635011397 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635011398 Amidase; Region: Amidase; cl11426 675635011399 putative amidase; Provisional; Region: PRK06169 675635011400 Amidase; Region: Amidase; cl11426 675635011401 Amidase; Region: Amidase; cl11426 675635011402 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 675635011403 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 675635011404 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635011405 Walker A/P-loop; other site 675635011406 ATP binding site [chemical binding]; other site 675635011407 Q-loop/lid; other site 675635011408 ABC transporter signature motif; other site 675635011409 Walker B; other site 675635011410 D-loop; other site 675635011411 H-loop/switch region; other site 675635011412 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635011413 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 675635011414 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635011415 Walker A/P-loop; other site 675635011416 ATP binding site [chemical binding]; other site 675635011417 Q-loop/lid; other site 675635011418 ABC transporter signature motif; other site 675635011419 Walker B; other site 675635011420 D-loop; other site 675635011421 H-loop/switch region; other site 675635011422 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635011423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635011424 dimer interface [polypeptide binding]; other site 675635011425 conserved gate region; other site 675635011426 putative PBP binding loops; other site 675635011427 ABC-ATPase subunit interface; other site 675635011428 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635011429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635011430 putative PBP binding loops; other site 675635011431 dimer interface [polypeptide binding]; other site 675635011432 ABC-ATPase subunit interface; other site 675635011433 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 675635011434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635011435 DNA-binding site [nucleotide binding]; DNA binding site 675635011436 UTRA domain; Region: UTRA; cl01230 675635011437 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 675635011438 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635011439 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 675635011440 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 675635011441 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 675635011442 dimer interface [polypeptide binding]; other site 675635011443 active site 675635011444 catalytic residue [active] 675635011445 TIGR03085 family protein; Region: TIGR03085 675635011446 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635011447 Thymidylate synthase complementing protein; Region: Thy1; cl03630 675635011448 HicB family; Region: HicB; pfam05534 675635011449 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 675635011450 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 675635011451 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 675635011452 EamA-like transporter family; Region: EamA; cl01037 675635011453 EamA-like transporter family; Region: EamA; cl01037 675635011454 dihydrodipicolinate reductase; Provisional; Region: PRK00048 675635011455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011456 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 675635011457 Protein of unknown function (DUF456); Region: DUF456; cl01069 675635011458 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 675635011459 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 675635011460 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 675635011461 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 675635011462 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 675635011463 oligomer interface [polypeptide binding]; other site 675635011464 RNA binding site [nucleotide binding]; other site 675635011465 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 675635011466 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 675635011467 RNase E interface [polypeptide binding]; other site 675635011468 trimer interface [polypeptide binding]; other site 675635011469 active site 675635011470 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 675635011471 putative nucleic acid binding region [nucleotide binding]; other site 675635011472 G-X-X-G motif; other site 675635011473 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 675635011474 RNA binding site [nucleotide binding]; other site 675635011475 domain interface; other site 675635011476 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 675635011477 16S/18S rRNA binding site [nucleotide binding]; other site 675635011478 S13e-L30e interaction site [polypeptide binding]; other site 675635011479 25S rRNA binding site [nucleotide binding]; other site 675635011480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635011481 non-specific DNA binding site [nucleotide binding]; other site 675635011482 salt bridge; other site 675635011483 sequence-specific DNA binding site [nucleotide binding]; other site 675635011484 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 675635011485 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 675635011486 active site 675635011487 Riboflavin kinase; Region: Flavokinase; cl03312 675635011488 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 675635011489 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 675635011490 RNA binding site [nucleotide binding]; other site 675635011491 active site 675635011492 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 675635011493 MatE; Region: MatE; cl10513 675635011494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011495 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 675635011496 Ribosome-binding factor A; Region: RBFA; cl00542 675635011497 Protein of unknown function (DUF503); Region: DUF503; cl00669 675635011498 translation initiation factor IF-2; Region: IF-2; TIGR00487 675635011499 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 675635011500 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 675635011501 G1 box; other site 675635011502 putative GEF interaction site [polypeptide binding]; other site 675635011503 GTP/Mg2+ binding site [chemical binding]; other site 675635011504 Switch I region; other site 675635011505 G2 box; other site 675635011506 G3 box; other site 675635011507 Switch II region; other site 675635011508 G4 box; other site 675635011509 G5 box; other site 675635011510 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 675635011511 Translation-initiation factor 2; Region: IF-2; pfam11987 675635011512 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 675635011513 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 675635011514 NusA N-terminal domain; Region: NusA_N; pfam08529 675635011515 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 675635011516 RNA binding site [nucleotide binding]; other site 675635011517 homodimer interface [polypeptide binding]; other site 675635011518 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 675635011519 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 675635011520 G-X-X-G motif; other site 675635011521 ribosome maturation protein RimP; Reviewed; Region: PRK00092 675635011522 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 675635011523 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 675635011524 Sm1 motif; other site 675635011525 D1 - D2 interaction site; other site 675635011526 D3 - B interaction site; other site 675635011527 Hfq - Hfq interaction site; other site 675635011528 RNA binding pocket [nucleotide binding]; other site 675635011529 Sm2 motif; other site 675635011530 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 675635011531 dinuclear metal binding motif [ion binding]; other site 675635011532 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 675635011533 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635011534 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 675635011535 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 675635011536 putative active site [active] 675635011537 prolyl-tRNA synthetase; Provisional; Region: PRK09194 675635011538 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 675635011539 motif 1; other site 675635011540 dimer interface [polypeptide binding]; other site 675635011541 active site 675635011542 motif 2; other site 675635011543 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 675635011544 putative deacylase active site [active] 675635011545 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 675635011546 active site 675635011547 motif 3; other site 675635011548 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 675635011549 anticodon binding site; other site 675635011550 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 675635011551 DNA-binding site [nucleotide binding]; DNA binding site 675635011552 RNA-binding motif; other site 675635011553 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 675635011554 DNA-binding site [nucleotide binding]; DNA binding site 675635011555 RNA-binding motif; other site 675635011556 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 675635011557 DNA-binding site [nucleotide binding]; DNA binding site 675635011558 RNA-binding motif; other site 675635011559 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 675635011560 DNA-binding site [nucleotide binding]; DNA binding site 675635011561 RNA-binding motif; other site 675635011562 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635011563 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635011564 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 675635011565 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 675635011566 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 675635011567 homodimer interface [polypeptide binding]; other site 675635011568 substrate-cofactor binding pocket; other site 675635011569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635011570 catalytic residue [active] 675635011571 Protein of unknown function (DUF328); Region: DUF328; cl01143 675635011572 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 675635011573 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635011574 ATP binding site [chemical binding]; other site 675635011575 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635011576 DEAD-like helicases superfamily; Region: DEXDc; smart00487 675635011577 ATP binding site [chemical binding]; other site 675635011578 putative Mg++ binding site [ion binding]; other site 675635011579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635011580 nucleotide binding region [chemical binding]; other site 675635011581 ATP-binding site [chemical binding]; other site 675635011582 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 675635011583 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635011584 active site 675635011585 HIGH motif; other site 675635011586 nucleotide binding site [chemical binding]; other site 675635011587 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635011588 active site 675635011589 KMSKS motif; other site 675635011590 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 675635011591 tRNA binding surface [nucleotide binding]; other site 675635011592 anticodon binding site; other site 675635011593 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635011594 mycothione reductase; Reviewed; Region: PRK07846 675635011595 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635011596 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635011597 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 675635011598 Di-iron ligands [ion binding]; other site 675635011599 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 675635011600 putative acyl-acceptor binding pocket; other site 675635011601 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 675635011602 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 675635011603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011605 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 675635011606 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 675635011607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011608 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 675635011609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011610 Phospholipid methyltransferase; Region: PEMT; cl00763 675635011611 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 675635011612 catalytic triad [active] 675635011613 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635011614 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 675635011615 active site 675635011616 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635011617 Predicted acetyltransferase [General function prediction only]; Region: COG3393 675635011618 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 675635011619 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635011620 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 675635011621 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 675635011622 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 675635011623 polynucleotide kinase; Provisional; Region: pseT; PHA02530 675635011624 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 675635011625 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 675635011626 active site 675635011627 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 675635011628 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 675635011629 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 675635011630 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 675635011631 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 675635011632 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 675635011633 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 675635011634 nucleotide binding site [chemical binding]; other site 675635011635 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635011636 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635011637 Helix-turn-helix domains; Region: HTH; cl00088 675635011638 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 675635011639 active site 675635011640 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 675635011641 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 675635011642 active site 675635011643 DNA binding site [nucleotide binding] 675635011644 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 675635011645 DNA binding site [nucleotide binding] 675635011646 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 675635011647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635011648 FeS/SAM binding site; other site 675635011649 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635011650 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 675635011651 iron-sulfur cluster [ion binding]; other site 675635011652 [2Fe-2S] cluster binding site [ion binding]; other site 675635011653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011654 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 675635011655 ribosome recycling factor; Reviewed; Region: frr; PRK00083 675635011656 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 675635011657 hinge region; other site 675635011658 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 675635011659 putative nucleotide binding site [chemical binding]; other site 675635011660 uridine monophosphate binding site [chemical binding]; other site 675635011661 homohexameric interface [polypeptide binding]; other site 675635011662 elongation factor Ts; Provisional; Region: tsf; PRK09377 675635011663 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 675635011664 Elongation factor TS; Region: EF_TS; pfam00889 675635011665 Elongation factor TS; Region: EF_TS; pfam00889 675635011666 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 675635011667 rRNA interaction site [nucleotide binding]; other site 675635011668 S8 interaction site; other site 675635011669 putative laminin-1 binding site; other site 675635011670 Peptidase family M23; Region: Peptidase_M23; pfam01551 675635011671 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 675635011672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635011673 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635011674 DNA binding residues [nucleotide binding] 675635011675 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 675635011676 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635011677 active site 675635011678 DNA binding site [nucleotide binding] 675635011679 Int/Topo IB signature motif; other site 675635011680 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 675635011681 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 675635011682 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 675635011683 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 675635011684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635011685 Walker A motif; other site 675635011686 ATP binding site [chemical binding]; other site 675635011687 Walker B motif; other site 675635011688 arginine finger; other site 675635011689 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 675635011690 Restriction endonuclease; Region: Mrr_cat; cl00516 675635011691 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 675635011692 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 675635011693 RNA/DNA hybrid binding site [nucleotide binding]; other site 675635011694 active site 675635011695 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 675635011696 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 675635011697 Catalytic site [active] 675635011698 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 675635011699 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 675635011700 MgtC family; Region: MgtC; pfam02308 675635011701 Clp protease ATP binding subunit; Region: clpC; CHL00095 675635011702 Clp amino terminal domain; Region: Clp_N; pfam02861 675635011703 Clp amino terminal domain; Region: Clp_N; pfam02861 675635011704 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 675635011705 RimM N-terminal domain; Region: RimM; pfam01782 675635011706 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 675635011707 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 675635011708 CAAX protease self-immunity; Region: Abi; cl00558 675635011709 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635011710 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635011711 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635011712 active site 675635011713 signal recognition particle protein; Provisional; Region: PRK10867 675635011714 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 675635011715 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 675635011716 P loop; other site 675635011717 GTP binding site [chemical binding]; other site 675635011718 Signal peptide binding domain; Region: SRP_SPB; pfam02978 675635011719 Nitrogen regulatory protein P-II; Region: P-II; cl00412 675635011720 PII uridylyl-transferase; Provisional; Region: PRK03381 675635011721 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 675635011722 metal binding triad; other site 675635011723 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 675635011724 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 675635011725 Nitrogen regulatory protein P-II; Region: P-II; cl00412 675635011726 Nitrogen regulatory protein P-II; Region: P-II; smart00938 675635011727 Nitrogen regulatory protein P-II; Region: P-II; cl00412 675635011728 Nitrogen regulatory protein P-II; Region: P-II; smart00938 675635011729 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 675635011730 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 675635011731 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 675635011732 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635011733 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 675635011734 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 675635011735 Walker A/P-loop; other site 675635011736 ATP binding site [chemical binding]; other site 675635011737 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 675635011738 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 675635011739 ABC transporter signature motif; other site 675635011740 Walker B; other site 675635011741 D-loop; other site 675635011742 H-loop/switch region; other site 675635011743 Acylphosphatase; Region: Acylphosphatase; cl00551 675635011744 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 675635011745 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 675635011746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635011747 active site 675635011748 phosphorylation site [posttranslational modification] 675635011749 intermolecular recognition site; other site 675635011750 dimerization interface [polypeptide binding]; other site 675635011751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635011752 DNA binding site [nucleotide binding] 675635011753 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 675635011754 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 675635011755 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 675635011756 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 675635011757 DNA binding site [nucleotide binding] 675635011758 catalytic residue [active] 675635011759 H2TH interface [polypeptide binding]; other site 675635011760 putative catalytic residues [active] 675635011761 turnover-facilitating residue; other site 675635011762 intercalation triad [nucleotide binding]; other site 675635011763 8OG recognition residue [nucleotide binding]; other site 675635011764 putative reading head residues; other site 675635011765 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 675635011766 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 675635011767 ribonuclease III; Reviewed; Region: rnc; PRK00102 675635011768 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 675635011769 dimerization interface [polypeptide binding]; other site 675635011770 active site 675635011771 metal binding site [ion binding]; metal-binding site 675635011772 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 675635011773 dsRNA binding site [nucleotide binding]; other site 675635011774 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 675635011775 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 675635011776 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 675635011777 Plant ATP synthase F0; Region: YMF19; cl07975 675635011778 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 675635011779 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 675635011780 active site 675635011781 (T/H)XGH motif; other site 675635011782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635011783 S-adenosylmethionine binding site [chemical binding]; other site 675635011784 pyruvate carboxylase; Reviewed; Region: PRK12999 675635011785 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635011786 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635011787 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 675635011788 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 675635011789 active site 675635011790 catalytic residues [active] 675635011791 metal binding site [ion binding]; metal-binding site 675635011792 homodimer binding site [polypeptide binding]; other site 675635011793 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635011794 carboxyltransferase (CT) interaction site; other site 675635011795 biotinylation site [posttranslational modification]; other site 675635011796 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 675635011797 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 675635011798 generic binding surface II; other site 675635011799 ssDNA binding site; other site 675635011800 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635011801 ATP binding site [chemical binding]; other site 675635011802 putative Mg++ binding site [ion binding]; other site 675635011803 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635011804 nucleotide binding region [chemical binding]; other site 675635011805 ATP-binding site [chemical binding]; other site 675635011806 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 675635011807 DAK2 domain; Region: Dak2; cl03685 675635011808 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 675635011809 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 675635011810 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 675635011811 ligand binding site [chemical binding]; other site 675635011812 active site 675635011813 UGI interface [polypeptide binding]; other site 675635011814 catalytic site [active] 675635011815 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 675635011816 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 675635011817 trimer interface [polypeptide binding]; other site 675635011818 putative metal binding site [ion binding]; other site 675635011819 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 675635011820 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 675635011821 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 675635011822 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 675635011823 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 675635011824 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 675635011825 active site 675635011826 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 675635011827 FAD binding domain; Region: FAD_binding_4; pfam01565 675635011828 FAD binding domain; Region: FAD_binding_4; pfam01565 675635011829 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 675635011830 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 675635011831 4Fe-4S binding domain; Region: Fer4; cl02805 675635011832 Cysteine-rich domain; Region: CCG; pfam02754 675635011833 Cysteine-rich domain; Region: CCG; pfam02754 675635011834 DinB superfamily; Region: DinB_2; pfam12867 675635011835 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635011836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635011837 DNA-binding site [nucleotide binding]; DNA binding site 675635011838 FCD domain; Region: FCD; cl11656 675635011839 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 675635011840 FAD binding domain; Region: FAD_binding_4; pfam01565 675635011841 FAD binding domain; Region: FAD_binding_4; pfam01565 675635011842 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 675635011843 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 675635011844 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 675635011845 Cysteine-rich domain; Region: CCG; pfam02754 675635011846 Cysteine-rich domain; Region: CCG; pfam02754 675635011847 thiamine monophosphate kinase; Provisional; Region: PRK05731 675635011848 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 675635011849 ATP binding site [chemical binding]; other site 675635011850 dimerization interface [polypeptide binding]; other site 675635011851 Helix-turn-helix domains; Region: HTH; cl00088 675635011852 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 675635011853 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 675635011854 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 675635011855 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635011856 acetyl-CoA synthetase; Provisional; Region: PRK00174 675635011857 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 675635011858 AMP-binding enzyme; Region: AMP-binding; cl15778 675635011859 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635011860 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635011861 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635011862 active site 675635011863 Isochorismatase family; Region: Isochorismatase; pfam00857 675635011864 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 675635011865 catalytic triad [active] 675635011866 conserved cis-peptide bond; other site 675635011867 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635011868 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 675635011869 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635011870 Mechanosensitive ion channel; Region: MS_channel; pfam00924 675635011871 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 675635011872 apolar tunnel; other site 675635011873 heme binding site [chemical binding]; other site 675635011874 dimerization interface [polypeptide binding]; other site 675635011875 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 675635011876 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 675635011877 active site 675635011878 catalytic site [active] 675635011879 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 675635011880 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 675635011881 active site 675635011882 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 675635011883 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 675635011884 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 675635011885 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 675635011886 ABC transporter; Region: ABC_tran_2; pfam12848 675635011887 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 675635011888 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 675635011889 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 675635011890 dimer interface [polypeptide binding]; other site 675635011891 ssDNA binding site [nucleotide binding]; other site 675635011892 tetramer (dimer of dimers) interface [polypeptide binding]; other site 675635011893 Copper resistance protein D; Region: CopD; cl00563 675635011894 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 675635011895 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 675635011896 active site 675635011897 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635011898 active site 675635011899 Int/Topo IB signature motif; other site 675635011900 DNA binding site [nucleotide binding] 675635011901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635011902 DNA-binding site [nucleotide binding]; DNA binding site 675635011903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635011904 Integrase core domain; Region: rve; cl01316 675635011905 transposase/IS protein; Provisional; Region: PRK09183 675635011906 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635011907 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 675635011908 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 675635011909 Walker A/P-loop; other site 675635011910 ATP binding site [chemical binding]; other site 675635011911 Q-loop/lid; other site 675635011912 ABC transporter signature motif; other site 675635011913 Walker B; other site 675635011914 D-loop; other site 675635011915 H-loop/switch region; other site 675635011916 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 675635011917 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 675635011918 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 675635011919 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 675635011920 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 675635011921 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635011922 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635011923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 675635011924 dimerization interface [polypeptide binding]; other site 675635011925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635011926 dimer interface [polypeptide binding]; other site 675635011927 phosphorylation site [posttranslational modification] 675635011928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635011929 ATP binding site [chemical binding]; other site 675635011930 Mg2+ binding site [ion binding]; other site 675635011931 G-X-G motif; other site 675635011932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635011933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635011934 active site 675635011935 phosphorylation site [posttranslational modification] 675635011936 intermolecular recognition site; other site 675635011937 dimerization interface [polypeptide binding]; other site 675635011938 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635011939 DNA binding site [nucleotide binding] 675635011940 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 675635011941 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 675635011942 active site 675635011943 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635011944 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 675635011945 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 675635011946 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 675635011947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635011948 dimer interface [polypeptide binding]; other site 675635011949 phosphorylation site [posttranslational modification] 675635011950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635011951 ATP binding site [chemical binding]; other site 675635011952 Mg2+ binding site [ion binding]; other site 675635011953 G-X-G motif; other site 675635011954 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635011955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635011956 active site 675635011957 phosphorylation site [posttranslational modification] 675635011958 intermolecular recognition site; other site 675635011959 dimerization interface [polypeptide binding]; other site 675635011960 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635011961 DNA binding site [nucleotide binding] 675635011962 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 675635011963 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 675635011964 Imelysin; Region: Peptidase_M75; cl09159 675635011965 Iron permease FTR1 family; Region: FTR1; cl00475 675635011966 Helix-turn-helix domains; Region: HTH; cl00088 675635011967 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635011968 Acetokinase family; Region: Acetate_kinase; cl01029 675635011969 putative phosphoketolase; Provisional; Region: PRK05261 675635011970 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635011971 TPP-binding site [chemical binding]; other site 675635011972 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 675635011973 XFP C-terminal domain; Region: XFP_C; pfam09363 675635011974 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635011975 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635011976 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635011977 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635011978 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635011979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011980 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 675635011981 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 675635011982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 675635011983 Predicted kinase [General function prediction only]; Region: COG0645 675635011984 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635011985 FOG: CBS domain [General function prediction only]; Region: COG0517 675635011986 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635011987 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 675635011988 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635011989 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 675635011990 PAS domain; Region: PAS_9; pfam13426 675635011991 Winged helix-turn helix; Region: HTH_29; pfam13551 675635011992 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635011993 Helix-turn-helix domains; Region: HTH; cl00088 675635011994 Integrase core domain; Region: rve; cl01316 675635011995 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 675635011996 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635011997 active site 675635011998 DNA binding site [nucleotide binding] 675635011999 Int/Topo IB signature motif; other site 675635012000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635012001 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635012002 active site 675635012003 catalytic residues [active] 675635012004 DNA binding site [nucleotide binding] 675635012005 Int/Topo IB signature motif; other site 675635012006 transposase; Provisional; Region: PRK06526 675635012007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635012008 Walker A motif; other site 675635012009 ATP binding site [chemical binding]; other site 675635012010 Walker B motif; other site 675635012011 Integrase core domain; Region: rve; cl01316 675635012012 rod shape-determining protein MreB; Provisional; Region: PRK13930 675635012013 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 675635012014 NodB motif; other site 675635012015 putative active site [active] 675635012016 putative catalytic site [active] 675635012017 putative Zn binding site [ion binding]; other site 675635012018 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635012019 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 675635012020 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 675635012021 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 675635012022 active site 675635012023 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 675635012024 active site 675635012025 Helix-turn-helix domains; Region: HTH; cl00088 675635012026 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 675635012027 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 675635012028 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 675635012029 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 675635012030 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635012031 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635012032 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 675635012033 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 675635012034 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 675635012035 Predicted amidohydrolase [General function prediction only]; Region: COG0388 675635012036 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 675635012037 active site 675635012038 catalytic triad [active] 675635012039 dimer interface [polypeptide binding]; other site 675635012040 Helix-turn-helix domains; Region: HTH; cl00088 675635012041 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 675635012042 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 675635012043 catalytic residues [active] 675635012044 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 675635012045 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 675635012046 Winged helix-turn helix; Region: HTH_29; pfam13551 675635012047 Helix-turn-helix domains; Region: HTH; cl00088 675635012048 Integrase core domain; Region: rve; cl01316 675635012049 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635012050 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635012051 DNA binding residues [nucleotide binding] 675635012052 dimerization interface [polypeptide binding]; other site 675635012053 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 675635012054 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 675635012055 Tubulin like; Region: Tubulin_2; pfam13809 675635012056 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 675635012057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012058 hypothetical protein; Validated; Region: PRK05868 675635012059 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 675635012060 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 675635012061 active site residue [active] 675635012062 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635012063 active site residue [active] 675635012064 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635012065 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635012066 Helix-turn-helix domains; Region: HTH; cl00088 675635012067 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635012068 substrate binding site [chemical binding]; other site 675635012069 oxyanion hole (OAH) forming residues; other site 675635012070 trimer interface [polypeptide binding]; other site 675635012071 formyl-coenzyme A transferase; Provisional; Region: PRK05398 675635012072 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635012073 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635012074 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635012075 active site 675635012076 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635012077 AMP-binding enzyme; Region: AMP-binding; cl15778 675635012078 AMP-binding enzyme; Region: AMP-binding; cl15778 675635012079 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635012080 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635012081 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635012082 Methyltransferase domain; Region: Methyltransf_31; pfam13847 675635012083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635012084 S-adenosylmethionine binding site [chemical binding]; other site 675635012085 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635012086 Anaphase-promoting complex subunit 5; Region: Apc5; pfam12862 675635012087 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635012088 DNA binding residues [nucleotide binding] 675635012089 dimerization interface [polypeptide binding]; other site 675635012090 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635012091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635012092 DNA-binding site [nucleotide binding]; DNA binding site 675635012093 FCD domain; Region: FCD; cl11656 675635012094 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 675635012095 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 675635012096 putative active site [active] 675635012097 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 675635012098 domain_subunit interface; other site 675635012099 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 675635012100 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 675635012101 active site 675635012102 FMN binding site [chemical binding]; other site 675635012103 substrate binding site [chemical binding]; other site 675635012104 3Fe-4S cluster binding site [ion binding]; other site 675635012105 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 675635012106 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 675635012107 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 675635012108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012109 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 675635012110 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 675635012111 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635012112 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 675635012113 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 675635012114 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 675635012115 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 675635012116 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 675635012117 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 675635012118 putative active site [active] 675635012119 putative substrate binding site [chemical binding]; other site 675635012120 putative cosubstrate binding site; other site 675635012121 catalytic site [active] 675635012122 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 675635012123 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 675635012124 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 675635012125 homodimer interface [polypeptide binding]; other site 675635012126 NADP binding site [chemical binding]; other site 675635012127 substrate binding site [chemical binding]; other site 675635012128 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 675635012129 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635012130 dimer interface [polypeptide binding]; other site 675635012131 active site 675635012132 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 675635012133 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635012134 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635012135 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635012136 active site 675635012137 non-prolyl cis peptide bond; other site 675635012138 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 675635012139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635012140 dimer interface [polypeptide binding]; other site 675635012141 conserved gate region; other site 675635012142 putative PBP binding loops; other site 675635012143 ABC-ATPase subunit interface; other site 675635012144 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 675635012145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635012146 Walker A/P-loop; other site 675635012147 ATP binding site [chemical binding]; other site 675635012148 Q-loop/lid; other site 675635012149 ABC transporter signature motif; other site 675635012150 Walker B; other site 675635012151 D-loop; other site 675635012152 H-loop/switch region; other site 675635012153 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 675635012154 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 675635012155 substrate binding pocket [chemical binding]; other site 675635012156 membrane-bound complex binding site; other site 675635012157 hinge residues; other site 675635012158 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635012159 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 675635012160 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635012161 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635012162 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 675635012163 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635012164 Walker A/P-loop; other site 675635012165 ATP binding site [chemical binding]; other site 675635012166 Q-loop/lid; other site 675635012167 ABC transporter signature motif; other site 675635012168 Walker B; other site 675635012169 D-loop; other site 675635012170 H-loop/switch region; other site 675635012171 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635012172 Walker A/P-loop; other site 675635012173 ATP binding site [chemical binding]; other site 675635012174 Q-loop/lid; other site 675635012175 ABC transporter signature motif; other site 675635012176 Walker B; other site 675635012177 D-loop; other site 675635012178 H-loop/switch region; other site 675635012179 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635012180 Helix-turn-helix domains; Region: HTH; cl00088 675635012181 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635012182 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635012183 substrate binding pocket [chemical binding]; other site 675635012184 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635012185 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635012186 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635012187 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635012188 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635012189 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 675635012190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635012191 substrate binding site [chemical binding]; other site 675635012192 oxyanion hole (OAH) forming residues; other site 675635012193 trimer interface [polypeptide binding]; other site 675635012194 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635012195 Helix-turn-helix domains; Region: HTH; cl00088 675635012196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635012197 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635012198 putative substrate translocation pore; other site 675635012199 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635012200 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635012201 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635012202 Helix-turn-helix domains; Region: HTH; cl00088 675635012203 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 675635012204 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635012205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635012206 putative DNA binding site [nucleotide binding]; other site 675635012207 dimerization interface [polypeptide binding]; other site 675635012208 putative Zn2+ binding site [ion binding]; other site 675635012209 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635012210 hydrophobic ligand binding site; other site 675635012211 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 675635012212 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635012213 FAD binding domain; Region: FAD_binding_4; pfam01565 675635012214 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 675635012215 sensor protein QseC; Provisional; Region: PRK10337 675635012216 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635012217 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635012218 Helix-turn-helix domains; Region: HTH; cl00088 675635012219 HicB family; Region: HicB; pfam05534 675635012220 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635012221 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 675635012222 Walker A/P-loop; other site 675635012223 ATP binding site [chemical binding]; other site 675635012224 Q-loop/lid; other site 675635012225 ABC transporter signature motif; other site 675635012226 Walker B; other site 675635012227 D-loop; other site 675635012228 H-loop/switch region; other site 675635012229 ABC-2 type transporter; Region: ABC2_membrane; cl11417 675635012230 ABC-2 type transporter; Region: ABC2_membrane; cl11417 675635012231 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635012232 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635012233 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635012234 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 675635012235 active site 675635012236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635012237 S-adenosylmethionine binding site [chemical binding]; other site 675635012238 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 675635012239 substrate binding site [chemical binding]; other site 675635012240 metal binding site [ion binding]; metal-binding site 675635012241 dimer interface [polypeptide binding]; other site 675635012242 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635012243 E3 interaction surface; other site 675635012244 lipoyl attachment site [posttranslational modification]; other site 675635012245 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635012246 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 675635012247 PYR/PP interface [polypeptide binding]; other site 675635012248 dimer interface [polypeptide binding]; other site 675635012249 TPP binding site [chemical binding]; other site 675635012250 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635012251 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635012252 tetramer interface [polypeptide binding]; other site 675635012253 TPP-binding site [chemical binding]; other site 675635012254 heterodimer interface [polypeptide binding]; other site 675635012255 phosphorylation loop region [posttranslational modification] 675635012256 Predicted transcriptional regulator [Transcription]; Region: COG1959 675635012257 Helix-turn-helix domains; Region: HTH; cl00088 675635012258 NADH(P)-binding; Region: NAD_binding_10; pfam13460 675635012259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012260 NAD(P) binding site [chemical binding]; other site 675635012261 active site 675635012262 Helix-turn-helix domains; Region: HTH; cl00088 675635012263 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 675635012264 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 675635012265 Cl- selectivity filter; other site 675635012266 Cl- binding residues [ion binding]; other site 675635012267 pore gating glutamate residue; other site 675635012268 dimer interface [polypeptide binding]; other site 675635012269 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 675635012270 enoyl-CoA hydratase; Provisional; Region: PRK06688 675635012271 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635012272 substrate binding site [chemical binding]; other site 675635012273 oxyanion hole (OAH) forming residues; other site 675635012274 trimer interface [polypeptide binding]; other site 675635012275 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635012276 DNA binding residues [nucleotide binding] 675635012277 TOBE domain; Region: TOBE_2; cl01440 675635012278 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635012279 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 675635012280 catalytic triad [active] 675635012281 conserved cis-peptide bond; other site 675635012282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012283 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 675635012284 NAD(P) binding site [chemical binding]; other site 675635012285 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 675635012286 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635012287 active site 675635012288 catalytic tetrad [active] 675635012289 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635012290 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 675635012291 active site 675635012292 DNA binding site [nucleotide binding] 675635012293 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 675635012294 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 675635012295 DNA binding site [nucleotide binding] 675635012296 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 675635012297 nucleotide binding site [chemical binding]; other site 675635012298 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635012299 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 675635012300 Sulfate transporter family; Region: Sulfate_transp; cl15842 675635012301 Sulfate transporter family; Region: Sulfate_transp; cl15842 675635012302 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 675635012303 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635012304 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635012305 putative NAD(P) binding site [chemical binding]; other site 675635012306 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635012307 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635012308 putative NAD(P) binding site [chemical binding]; other site 675635012309 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 675635012310 Moco binding site; other site 675635012311 metal coordination site [ion binding]; other site 675635012312 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 675635012313 FAD binding pocket [chemical binding]; other site 675635012314 conserved FAD binding motif [chemical binding]; other site 675635012315 phosphate binding motif [ion binding]; other site 675635012316 beta-alpha-beta structure motif; other site 675635012317 NAD binding pocket [chemical binding]; other site 675635012318 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 675635012319 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 675635012320 putative uracil binding site [chemical binding]; other site 675635012321 putative active site [active] 675635012322 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635012323 OsmC-like protein; Region: OsmC; cl00767 675635012324 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 675635012325 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 675635012326 D-pathway; other site 675635012327 Putative ubiquinol binding site [chemical binding]; other site 675635012328 Low-spin heme (heme b) binding site [chemical binding]; other site 675635012329 Putative water exit pathway; other site 675635012330 Binuclear center (heme o3/CuB) [ion binding]; other site 675635012331 K-pathway; other site 675635012332 Putative proton exit pathway; other site 675635012333 Ferritin-like domain; Region: Ferritin; pfam00210 675635012334 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 675635012335 dimerization interface [polypeptide binding]; other site 675635012336 DPS ferroxidase diiron center [ion binding]; other site 675635012337 ion pore; other site 675635012338 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 675635012339 putative active site [active] 675635012340 transaldolase; Provisional; Region: PRK03903 675635012341 catalytic residue [active] 675635012342 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 675635012343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635012344 Helix-turn-helix domains; Region: HTH; cl00088 675635012345 short chain dehydrogenase; Provisional; Region: PRK08263 675635012346 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 675635012347 NADP binding site [chemical binding]; other site 675635012348 active site 675635012349 steroid binding site; other site 675635012350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635012351 Helix-turn-helix domains; Region: HTH; cl00088 675635012352 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 675635012353 dimerization interface [polypeptide binding]; other site 675635012354 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 675635012355 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635012356 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635012357 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 675635012358 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635012359 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 675635012360 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 675635012361 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 675635012362 putative substrate binding site [chemical binding]; other site 675635012363 putative ATP binding site [chemical binding]; other site 675635012364 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 675635012365 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635012366 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 675635012367 hypothetical protein; Provisional; Region: PRK07945 675635012368 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 675635012369 CHAD domain; Region: CHAD; cl10506 675635012370 FAD binding domain; Region: FAD_binding_4; pfam01565 675635012371 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 675635012372 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 675635012373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012374 O-succinylbenzoate synthase; Provisional; Region: PRK02901 675635012375 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635012376 metal binding site [ion binding]; metal-binding site 675635012377 substrate binding pocket [chemical binding]; other site 675635012378 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635012379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012380 Helix-turn-helix domains; Region: HTH; cl00088 675635012381 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 675635012382 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 675635012383 FAD binding pocket [chemical binding]; other site 675635012384 FAD binding motif [chemical binding]; other site 675635012385 phosphate binding motif [ion binding]; other site 675635012386 NAD binding pocket [chemical binding]; other site 675635012387 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635012388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635012389 active site 675635012390 phosphorylation site [posttranslational modification] 675635012391 intermolecular recognition site; other site 675635012392 dimerization interface [polypeptide binding]; other site 675635012393 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635012394 DNA binding site [nucleotide binding] 675635012395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635012396 dimer interface [polypeptide binding]; other site 675635012397 phosphorylation site [posttranslational modification] 675635012398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635012399 ATP binding site [chemical binding]; other site 675635012400 Mg2+ binding site [ion binding]; other site 675635012401 G-X-G motif; other site 675635012402 Bacitracin resistance protein BacA; Region: BacA; cl00858 675635012403 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 675635012404 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 675635012405 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 675635012406 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635012407 active site 675635012408 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 675635012409 Helix-turn-helix domains; Region: HTH; cl00088 675635012410 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 675635012411 putative hydrophobic ligand binding site [chemical binding]; other site 675635012412 protein interface [polypeptide binding]; other site 675635012413 gate; other site 675635012414 acyl-CoA synthetase; Validated; Region: PRK07788 675635012415 AMP-binding enzyme; Region: AMP-binding; cl15778 675635012416 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635012417 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635012418 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635012419 Bacterial PH domain; Region: DUF304; cl01348 675635012420 Bacterial PH domain; Region: DUF304; cl01348 675635012421 Predicted membrane protein [Function unknown]; Region: COG3428 675635012422 Bacterial PH domain; Region: DUF304; cl01348 675635012423 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 675635012424 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 675635012425 catalytic site [active] 675635012426 putative active site [active] 675635012427 putative substrate binding site [chemical binding]; other site 675635012428 dimer interface [polypeptide binding]; other site 675635012429 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 675635012430 Flavoprotein; Region: Flavoprotein; cl08021 675635012431 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 675635012432 catalytic triad [active] 675635012433 conserved cis-peptide bond; other site 675635012434 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 675635012435 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 675635012436 Walker A/P-loop; other site 675635012437 ATP binding site [chemical binding]; other site 675635012438 Q-loop/lid; other site 675635012439 ABC transporter signature motif; other site 675635012440 Walker B; other site 675635012441 D-loop; other site 675635012442 H-loop/switch region; other site 675635012443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635012444 dimer interface [polypeptide binding]; other site 675635012445 conserved gate region; other site 675635012446 putative PBP binding loops; other site 675635012447 ABC-ATPase subunit interface; other site 675635012448 NMT1/THI5 like; Region: NMT1; pfam09084 675635012449 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 675635012450 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 675635012451 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 675635012452 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635012453 DNA-binding site [nucleotide binding]; DNA binding site 675635012454 FCD domain; Region: FCD; cl11656 675635012455 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635012456 Helix-turn-helix domains; Region: HTH; cl00088 675635012457 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 675635012458 putative dimerization interface [polypeptide binding]; other site 675635012459 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635012460 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635012461 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635012462 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 675635012463 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635012464 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635012465 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635012466 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635012467 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635012468 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635012469 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635012470 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635012471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012472 NAD(P) binding site [chemical binding]; other site 675635012473 active site 675635012474 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635012475 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635012476 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635012477 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635012478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635012479 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 675635012480 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635012481 ligand binding site [chemical binding]; other site 675635012482 flexible hinge region; other site 675635012483 Helix-turn-helix domains; Region: HTH; cl00088 675635012484 putative switch regulator; other site 675635012485 non-specific DNA interactions [nucleotide binding]; other site 675635012486 DNA binding site [nucleotide binding] 675635012487 sequence specific DNA binding site [nucleotide binding]; other site 675635012488 putative cAMP binding site [chemical binding]; other site 675635012489 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 675635012490 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635012491 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 675635012492 AMP-binding enzyme; Region: AMP-binding; cl15778 675635012493 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 675635012494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012495 CoA-ligase; Region: Ligase_CoA; cl02894 675635012496 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635012497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012498 FAD binding domain; Region: FAD_binding_3; pfam01494 675635012499 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635012500 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 675635012501 Cupin domain; Region: Cupin_2; cl09118 675635012502 Cupin domain; Region: Cupin_2; cl09118 675635012503 PaaX-like protein; Region: PaaX; pfam07848 675635012504 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 675635012505 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 675635012506 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 675635012507 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 675635012508 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 675635012509 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 675635012510 glycerol kinase; Provisional; Region: glpK; PRK00047 675635012511 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 675635012512 N- and C-terminal domain interface [polypeptide binding]; other site 675635012513 active site 675635012514 MgATP binding site [chemical binding]; other site 675635012515 catalytic site [active] 675635012516 metal binding site [ion binding]; metal-binding site 675635012517 carbohydrate binding site [chemical binding]; other site 675635012518 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635012519 Helix-turn-helix domains; Region: HTH; cl00088 675635012520 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635012521 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 675635012522 amphipathic channel; other site 675635012523 Asn-Pro-Ala signature motifs; other site 675635012524 glycerol kinase; Provisional; Region: glpK; PRK00047 675635012525 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 675635012526 N- and C-terminal domain interface [polypeptide binding]; other site 675635012527 putative active site [active] 675635012528 putative MgATP binding site [chemical binding]; other site 675635012529 catalytic site [active] 675635012530 metal binding site [ion binding]; metal-binding site 675635012531 putative homotetramer interface [polypeptide binding]; other site 675635012532 putative glycerol binding site [chemical binding]; other site 675635012533 homodimer interface [polypeptide binding]; other site 675635012534 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 675635012535 kynureninase; Region: kynureninase; TIGR01814 675635012536 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635012537 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635012538 catalytic residue [active] 675635012539 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 675635012540 Predicted transcriptional regulator [Transcription]; Region: COG2345 675635012541 Helix-turn-helix domains; Region: HTH; cl00088 675635012542 Uncharacterized conserved protein [Function unknown]; Region: COG3391 675635012543 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 675635012544 NodB motif; other site 675635012545 active site 675635012546 catalytic site [active] 675635012547 metal binding site [ion binding]; metal-binding site 675635012548 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635012549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635012550 putative substrate translocation pore; other site 675635012551 Putative esterase; Region: Esterase; pfam00756 675635012552 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635012553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012554 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 675635012555 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 675635012556 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635012557 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 675635012558 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 675635012559 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635012560 catalytic core [active] 675635012561 Bacitracin resistance protein BacA; Region: BacA; cl00858 675635012562 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 675635012563 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635012564 active site 675635012565 catalytic tetrad [active] 675635012566 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 675635012567 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 675635012568 NAD(P) binding site [chemical binding]; other site 675635012569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012570 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 675635012571 NAD(P) binding site [chemical binding]; other site 675635012572 active site 675635012573 hypothetical protein; Provisional; Region: PRK07906 675635012574 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 675635012575 putative metal binding site [ion binding]; other site 675635012576 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635012577 catalytic core [active] 675635012578 Helix-turn-helix domains; Region: HTH; cl00088 675635012579 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 675635012580 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 675635012581 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635012582 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635012583 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 675635012584 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635012585 FeS/SAM binding site; other site 675635012586 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 675635012587 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 675635012588 glutaminase active site [active] 675635012589 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 675635012590 dimer interface [polypeptide binding]; other site 675635012591 active site 675635012592 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 675635012593 dimer interface [polypeptide binding]; other site 675635012594 active site 675635012595 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 675635012596 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 675635012597 putative active site [active] 675635012598 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635012599 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 675635012600 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635012601 Walker A/P-loop; other site 675635012602 ATP binding site [chemical binding]; other site 675635012603 Q-loop/lid; other site 675635012604 ABC transporter signature motif; other site 675635012605 Walker B; other site 675635012606 D-loop; other site 675635012607 H-loop/switch region; other site 675635012608 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635012609 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 675635012610 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635012611 Walker A/P-loop; other site 675635012612 ATP binding site [chemical binding]; other site 675635012613 Q-loop/lid; other site 675635012614 ABC transporter signature motif; other site 675635012615 Walker B; other site 675635012616 D-loop; other site 675635012617 H-loop/switch region; other site 675635012618 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635012619 AMP-binding enzyme; Region: AMP-binding; cl15778 675635012620 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635012621 Domain of unknown function (DUF427); Region: DUF427; cl00998 675635012622 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635012623 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 675635012624 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 675635012625 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 675635012626 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 675635012627 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 675635012628 TPP-binding site [chemical binding]; other site 675635012629 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 675635012630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635012631 multicopper oxidase; Provisional; Region: PRK10965 675635012632 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 675635012633 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 675635012634 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 675635012635 Helix-turn-helix domains; Region: HTH; cl00088 675635012636 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635012637 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635012638 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635012639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012640 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 675635012641 NAD(P) binding site [chemical binding]; other site 675635012642 active site 675635012643 Helix-turn-helix domains; Region: HTH; cl00088 675635012644 NMT1-like family; Region: NMT1_2; cl15260 675635012645 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 675635012646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635012647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635012648 dimer interface [polypeptide binding]; other site 675635012649 conserved gate region; other site 675635012650 putative PBP binding loops; other site 675635012651 ABC-ATPase subunit interface; other site 675635012652 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 675635012653 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 675635012654 Walker A/P-loop; other site 675635012655 ATP binding site [chemical binding]; other site 675635012656 Q-loop/lid; other site 675635012657 ABC transporter signature motif; other site 675635012658 Walker B; other site 675635012659 D-loop; other site 675635012660 H-loop/switch region; other site 675635012661 PAS domain; Region: PAS_9; pfam13426 675635012662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635012663 PAS domain; Region: PAS_9; pfam13426 675635012664 putative active site [active] 675635012665 heme pocket [chemical binding]; other site 675635012666 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635012667 metal binding site [ion binding]; metal-binding site 675635012668 active site 675635012669 I-site; other site 675635012670 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 675635012671 Malic enzyme, N-terminal domain; Region: malic; pfam00390 675635012672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012673 NAD(P) binding pocket [chemical binding]; other site 675635012674 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635012675 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635012676 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635012677 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 675635012678 DNA-binding response regulator CreB; Provisional; Region: PRK11083 675635012679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635012680 active site 675635012681 phosphorylation site [posttranslational modification] 675635012682 intermolecular recognition site; other site 675635012683 dimerization interface [polypeptide binding]; other site 675635012684 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635012685 DNA binding site [nucleotide binding] 675635012686 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635012687 dimer interface [polypeptide binding]; other site 675635012688 phosphorylation site [posttranslational modification] 675635012689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635012690 ATP binding site [chemical binding]; other site 675635012691 Mg2+ binding site [ion binding]; other site 675635012692 G-X-G motif; other site 675635012693 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 675635012694 Catalytic site [active] 675635012695 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 675635012696 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 675635012697 active site 675635012698 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635012699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 675635012700 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635012701 catalytic core [active] 675635012702 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 675635012703 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635012704 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 675635012705 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 675635012706 Transcription factor WhiB; Region: Whib; pfam02467 675635012707 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 675635012708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635012709 putative active site [active] 675635012710 heme pocket [chemical binding]; other site 675635012711 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 675635012712 Histidine kinase; Region: HisKA_2; cl06527 675635012713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635012714 ATP binding site [chemical binding]; other site 675635012715 Mg2+ binding site [ion binding]; other site 675635012716 G-X-G motif; other site 675635012717 Putative zinc-finger; Region: zf-HC2; cl15806 675635012718 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 675635012719 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635012720 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635012721 DNA binding residues [nucleotide binding] 675635012722 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 675635012723 putative deacylase active site [active] 675635012724 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 675635012725 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 675635012726 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 675635012727 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 675635012728 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 675635012729 hinge; other site 675635012730 active site 675635012731 Predicted GTPases [General function prediction only]; Region: COG1162 675635012732 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 675635012733 GTPase/Zn-binding domain interface [polypeptide binding]; other site 675635012734 GTP/Mg2+ binding site [chemical binding]; other site 675635012735 G4 box; other site 675635012736 G5 box; other site 675635012737 G1 box; other site 675635012738 Switch I region; other site 675635012739 G2 box; other site 675635012740 G3 box; other site 675635012741 Switch II region; other site 675635012742 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635012743 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635012744 active site 675635012745 ATP binding site [chemical binding]; other site 675635012746 substrate binding site [chemical binding]; other site 675635012747 activation loop (A-loop); other site 675635012748 Helix-turn-helix domains; Region: HTH; cl00088 675635012749 WHG domain; Region: WHG; pfam13305 675635012750 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 675635012751 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 675635012752 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635012753 NAD(P) binding site [chemical binding]; other site 675635012754 catalytic residues [active] 675635012755 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635012756 enoyl-CoA hydratase; Provisional; Region: PRK08260 675635012757 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635012758 substrate binding site [chemical binding]; other site 675635012759 oxyanion hole (OAH) forming residues; other site 675635012760 trimer interface [polypeptide binding]; other site 675635012761 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 675635012762 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 675635012763 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 675635012764 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 675635012765 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 675635012766 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 675635012767 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 675635012768 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635012769 phosphate binding site [ion binding]; other site 675635012770 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 675635012771 Helix-turn-helix domains; Region: HTH; cl00088 675635012772 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 675635012773 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 675635012774 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 675635012775 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 675635012776 30S subunit binding site; other site 675635012777 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 675635012778 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635012779 active site 675635012780 lipoprotein LpqB; Provisional; Region: PRK13616 675635012781 Sporulation and spore germination; Region: Germane; cl11253 675635012782 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 675635012783 dimerization interface [polypeptide binding]; other site 675635012784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635012785 dimer interface [polypeptide binding]; other site 675635012786 phosphorylation site [posttranslational modification] 675635012787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635012788 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635012789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635012790 active site 675635012791 phosphorylation site [posttranslational modification] 675635012792 intermolecular recognition site; other site 675635012793 dimerization interface [polypeptide binding]; other site 675635012794 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635012795 DNA binding site [nucleotide binding] 675635012796 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635012797 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635012798 nudix motif; other site 675635012799 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 675635012800 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 675635012801 oligomerization interface [polypeptide binding]; other site 675635012802 active site 675635012803 NAD+ binding site [chemical binding]; other site 675635012804 MutL protein; Region: MutL; pfam13941 675635012805 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635012806 AMP-binding enzyme; Region: AMP-binding; cl15778 675635012807 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635012808 Helix-turn-helix domains; Region: HTH; cl00088 675635012809 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635012810 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 675635012811 amino acid transporter; Region: 2A0306; TIGR00909 675635012812 Spore germination protein; Region: Spore_permease; cl15802 675635012813 Spore germination protein; Region: Spore_permease; cl15802 675635012814 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 675635012815 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 675635012816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635012817 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635012818 Helix-turn-helix domains; Region: HTH; cl00088 675635012819 Cation efflux family; Region: Cation_efflux; cl00316 675635012820 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 675635012821 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 675635012822 Trm112p-like protein; Region: Trm112p; cl01066 675635012823 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 675635012824 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 675635012825 active site 675635012826 substrate binding site [chemical binding]; other site 675635012827 metal binding site [ion binding]; metal-binding site 675635012828 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 675635012829 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 675635012830 Transcription factor WhiB; Region: Whib; pfam02467 675635012831 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 675635012832 active site 675635012833 putative substrate binding region [chemical binding]; other site 675635012834 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 675635012835 nudix motif; other site 675635012836 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 675635012837 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 675635012838 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 675635012839 FMN binding site [chemical binding]; other site 675635012840 dimer interface [polypeptide binding]; other site 675635012841 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 675635012842 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 675635012843 dimer interface [polypeptide binding]; other site 675635012844 phosphate binding site [ion binding]; other site 675635012845 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 675635012846 catalytic residues [active] 675635012847 dimer interface [polypeptide binding]; other site 675635012848 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 675635012849 minor groove reading motif; other site 675635012850 helix-hairpin-helix signature motif; other site 675635012851 active site 675635012852 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 675635012853 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 675635012854 active site 675635012855 Substrate binding site; other site 675635012856 Mg++ binding site; other site 675635012857 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635012858 putative CoA binding site [chemical binding]; other site 675635012859 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 675635012860 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635012861 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635012862 active site 675635012863 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 675635012864 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 675635012865 AMP-binding enzyme; Region: AMP-binding; cl15778 675635012866 threonine dehydratase; Validated; Region: PRK08639 675635012867 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 675635012868 tetramer interface [polypeptide binding]; other site 675635012869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635012870 catalytic residue [active] 675635012871 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 675635012872 putative Ile/Val binding site [chemical binding]; other site 675635012873 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 675635012874 Creatinine amidohydrolase; Region: Creatininase; cl00618 675635012875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635012876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 675635012877 TPR motif; other site 675635012878 binding surface 675635012879 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635012880 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635012881 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635012882 active site 675635012883 DNA binding site [nucleotide binding] 675635012884 Int/Topo IB signature motif; other site 675635012885 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635012886 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635012887 active site 675635012888 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635012889 Protein of unknown function (DUF419); Region: DUF419; cl15265 675635012890 AIR carboxylase; Region: AIRC; cl00310 675635012891 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 675635012892 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635012893 GtrA-like protein; Region: GtrA; cl00971 675635012894 sensory histidine kinase CreC; Provisional; Region: PRK11100 675635012895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 675635012896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635012897 ATP binding site [chemical binding]; other site 675635012898 Mg2+ binding site [ion binding]; other site 675635012899 G-X-G motif; other site 675635012900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635012901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635012902 active site 675635012903 phosphorylation site [posttranslational modification] 675635012904 intermolecular recognition site; other site 675635012905 dimerization interface [polypeptide binding]; other site 675635012906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635012907 DNA binding site [nucleotide binding] 675635012908 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 675635012909 active site 675635012910 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 675635012911 putative active site [active] 675635012912 putative catalytic site [active] 675635012913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635012914 Helix-turn-helix domains; Region: HTH; cl00088 675635012915 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635012916 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635012917 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 675635012918 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 675635012919 tetramer interface [polypeptide binding]; other site 675635012920 active site 675635012921 Mg2+/Mn2+ binding site [ion binding]; other site 675635012922 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 675635012923 dimer interface [polypeptide binding]; other site 675635012924 FMN binding site [chemical binding]; other site 675635012925 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635012926 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635012927 putative NAD(P) binding site [chemical binding]; other site 675635012928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 675635012929 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 675635012930 CGNR zinc finger; Region: zf-CGNR; pfam11706 675635012931 Helix-turn-helix domains; Region: HTH; cl00088 675635012932 Predicted transcriptional regulator [Transcription]; Region: COG1959 675635012933 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635012934 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635012935 active site 675635012936 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635012937 LytTr DNA-binding domain; Region: LytTR; cl04498 675635012938 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635012939 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635012940 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635012941 active site 675635012942 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 675635012943 active site 675635012944 catalytic residues [active] 675635012945 metal binding site [ion binding]; metal-binding site 675635012946 Bacterial PH domain; Region: DUF304; cl01348 675635012947 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 675635012948 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 675635012949 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 675635012950 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 675635012951 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 675635012952 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 675635012953 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 675635012954 Maf-like protein; Region: Maf; pfam02545 675635012955 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 675635012956 active site 675635012957 dimer interface [polypeptide binding]; other site 675635012958 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 675635012959 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 675635012960 active site residue [active] 675635012961 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 675635012962 active site residue [active] 675635012963 Fe-S metabolism associated domain; Region: SufE; cl00951 675635012964 Protein of unknown function (DUF692); Region: DUF692; cl01263 675635012965 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 675635012966 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635012967 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635012968 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 675635012969 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635012970 carboxyltransferase (CT) interaction site; other site 675635012971 biotinylation site [posttranslational modification]; other site 675635012972 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 675635012973 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635012974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635012975 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635012976 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 675635012977 putative active site pocket [active] 675635012978 dimerization interface [polypeptide binding]; other site 675635012979 putative catalytic residue [active] 675635012980 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 675635012981 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635012982 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635012983 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 675635012984 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635012985 carboxyltransferase (CT) interaction site; other site 675635012986 biotinylation site [posttranslational modification]; other site 675635012987 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 675635012988 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 675635012989 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 675635012990 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 675635012991 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 675635012992 putative active site [active] 675635012993 putative catalytic site [active] 675635012994 enoyl-CoA hydratase; Provisional; Region: PRK06688 675635012995 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635012996 substrate binding site [chemical binding]; other site 675635012997 oxyanion hole (OAH) forming residues; other site 675635012998 trimer interface [polypeptide binding]; other site 675635012999 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 675635013000 AMP-binding enzyme; Region: AMP-binding; cl15778 675635013001 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635013002 active site 2 [active] 675635013003 active site 1 [active] 675635013004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635013005 putative substrate translocation pore; other site 675635013006 Helix-turn-helix domains; Region: HTH; cl00088 675635013007 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635013008 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 675635013009 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 675635013010 metal binding site [ion binding]; metal-binding site 675635013011 putative dimer interface [polypeptide binding]; other site 675635013012 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635013013 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635013014 active site 675635013015 ATP binding site [chemical binding]; other site 675635013016 substrate binding site [chemical binding]; other site 675635013017 activation loop (A-loop); other site 675635013018 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 675635013019 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 675635013020 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 675635013021 active site 675635013022 substrate binding site [chemical binding]; other site 675635013023 metal binding site [ion binding]; metal-binding site 675635013024 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 675635013025 active site 675635013026 catalytic triad [active] 675635013027 oxyanion hole [active] 675635013028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635013029 active site 675635013030 haloalkane dehalogenase; Provisional; Region: PRK00870 675635013031 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 675635013032 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 675635013033 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635013034 active site 675635013035 MviN-like protein; Region: MVIN; pfam03023 675635013036 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 675635013037 hydrophobic ligand binding site; other site 675635013038 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 675635013039 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635013040 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 675635013041 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 675635013042 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 675635013043 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 675635013044 active site 675635013045 HIGH motif; other site 675635013046 dimer interface [polypeptide binding]; other site 675635013047 KMSKS motif; other site 675635013048 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 675635013049 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 675635013050 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635013051 AMP-binding enzyme; Region: AMP-binding; cl15778 675635013052 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 675635013053 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635013054 FO synthase; Reviewed; Region: fbiC; PRK09234 675635013055 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635013056 FeS/SAM binding site; other site 675635013057 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635013058 FeS/SAM binding site; other site 675635013059 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 675635013060 putative deacylase active site [active] 675635013061 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635013062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635013063 active site 675635013064 ATP binding site [chemical binding]; other site 675635013065 substrate binding site [chemical binding]; other site 675635013066 activation loop (A-loop); other site 675635013067 Septum formation; Region: Septum_form; pfam13845 675635013068 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 675635013069 putative catalytic site [active] 675635013070 putative metal binding site [ion binding]; other site 675635013071 putative phosphate binding site [ion binding]; other site 675635013072 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 675635013073 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 675635013074 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 675635013075 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 675635013076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013077 NAD(P) binding pocket [chemical binding]; other site 675635013078 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 675635013079 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 675635013080 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 675635013081 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 675635013082 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 675635013083 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 675635013084 generic binding surface I; other site 675635013085 generic binding surface II; other site 675635013086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635013087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635013088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635013089 Helix-turn-helix domains; Region: HTH; cl00088 675635013090 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 675635013091 catalytic residues [active] 675635013092 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 675635013093 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 675635013094 DNA binding residues [nucleotide binding] 675635013095 putative dimer interface [polypeptide binding]; other site 675635013096 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 675635013097 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635013098 phosphate binding site [ion binding]; other site 675635013099 Y-family of DNA polymerases; Region: PolY; cl12025 675635013100 active site 675635013101 DNA binding site [nucleotide binding] 675635013102 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 675635013103 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 675635013104 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635013105 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 675635013106 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 675635013107 purine monophosphate binding site [chemical binding]; other site 675635013108 dimer interface [polypeptide binding]; other site 675635013109 putative catalytic residues [active] 675635013110 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 675635013111 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 675635013112 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 675635013113 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 675635013114 active site 675635013115 substrate binding site [chemical binding]; other site 675635013116 cosubstrate binding site; other site 675635013117 catalytic site [active] 675635013118 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 675635013119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013120 CoA-ligase; Region: Ligase_CoA; cl02894 675635013121 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 675635013122 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635013123 CoA-ligase; Region: Ligase_CoA; cl02894 675635013124 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635013125 Peptidase family M23; Region: Peptidase_M23; pfam01551 675635013126 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 675635013127 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635013128 Family description; Region: UvrD_C_2; cl15862 675635013129 Chorismate mutase type II; Region: CM_2; cl00693 675635013130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635013131 Integrase core domain; Region: rve; cl01316 675635013132 transposase/IS protein; Provisional; Region: PRK09183 675635013133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635013134 Walker A motif; other site 675635013135 ATP binding site [chemical binding]; other site 675635013136 Walker B motif; other site 675635013137 arginine finger; other site 675635013138 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635013139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635013140 active site 675635013141 phosphorylation site [posttranslational modification] 675635013142 intermolecular recognition site; other site 675635013143 dimerization interface [polypeptide binding]; other site 675635013144 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635013145 DNA binding residues [nucleotide binding] 675635013146 dimerization interface [polypeptide binding]; other site 675635013147 PspC domain; Region: PspC; cl00864 675635013148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635013149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635013150 ATP binding site [chemical binding]; other site 675635013151 Mg2+ binding site [ion binding]; other site 675635013152 G-X-G motif; other site 675635013153 PspC domain; Region: PspC; cl00864 675635013154 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 675635013155 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 675635013156 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 675635013157 FAD binding site [chemical binding]; other site 675635013158 GMP synthase; Reviewed; Region: guaA; PRK00074 675635013159 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 675635013160 AMP/PPi binding site [chemical binding]; other site 675635013161 candidate oxyanion hole; other site 675635013162 catalytic triad [active] 675635013163 potential glutamine specificity residues [chemical binding]; other site 675635013164 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 675635013165 ATP Binding subdomain [chemical binding]; other site 675635013166 Ligand Binding sites [chemical binding]; other site 675635013167 Dimerization subdomain; other site 675635013168 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635013169 hydrophobic ligand binding site; other site 675635013170 Fic/DOC family; Region: Fic; cl00960 675635013171 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 675635013172 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 675635013173 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635013174 phosphate binding site [ion binding]; other site 675635013175 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 675635013176 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635013177 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 675635013178 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 675635013179 active site 675635013180 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 675635013181 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635013182 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635013183 DNA binding residues [nucleotide binding] 675635013184 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635013185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635013186 active site 675635013187 phosphorylation site [posttranslational modification] 675635013188 intermolecular recognition site; other site 675635013189 dimerization interface [polypeptide binding]; other site 675635013190 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635013191 DNA binding residues [nucleotide binding] 675635013192 dimerization interface [polypeptide binding]; other site 675635013193 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635013194 DNA binding residues [nucleotide binding] 675635013195 B12 binding domain; Region: B12-binding_2; cl03653 675635013196 Transcription factor WhiB; Region: Whib; pfam02467 675635013197 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 675635013198 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 675635013199 ring oligomerisation interface [polypeptide binding]; other site 675635013200 ATP/Mg binding site [chemical binding]; other site 675635013201 stacking interactions; other site 675635013202 hinge regions; other site 675635013203 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 675635013204 oligomerisation interface [polypeptide binding]; other site 675635013205 mobile loop; other site 675635013206 roof hairpin; other site 675635013207 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 675635013208 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635013209 active site 675635013210 catalytic tetrad [active] 675635013211 UGMP family protein; Validated; Region: PRK09604 675635013212 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 675635013213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635013214 Coenzyme A binding pocket [chemical binding]; other site 675635013215 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635013216 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 675635013217 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 675635013218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635013219 motif II; other site 675635013220 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 675635013221 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635013222 alanine racemase; Reviewed; Region: alr; PRK00053 675635013223 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 675635013224 active site 675635013225 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 675635013226 dimer interface [polypeptide binding]; other site 675635013227 substrate binding site [chemical binding]; other site 675635013228 catalytic residues [active] 675635013229 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 675635013230 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 675635013231 putative substrate binding site [chemical binding]; other site 675635013232 putative ATP binding site [chemical binding]; other site 675635013233 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 675635013234 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 675635013235 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 675635013236 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635013237 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 675635013238 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 675635013239 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 675635013240 active site 675635013241 substrate binding site [chemical binding]; other site 675635013242 metal binding site [ion binding]; metal-binding site 675635013243 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 675635013244 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 675635013245 23S rRNA interface [nucleotide binding]; other site 675635013246 L3 interface [polypeptide binding]; other site 675635013247 Proteins of 100 residues with WXG; Region: WXG100; cl02005 675635013248 Proteins of 100 residues with WXG; Region: WXG100; cl02005 675635013249 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635013250 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635013251 Amidase; Region: Amidase; cl11426 675635013252 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 675635013253 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 675635013254 Amidohydrolase; Region: Amidohydro_4; pfam13147 675635013255 active site 675635013256 oxidase reductase; Provisional; Region: PTZ00273 675635013257 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 675635013258 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 675635013259 Cupin domain; Region: Cupin_2; cl09118 675635013260 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 675635013261 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 675635013262 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635013263 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 675635013264 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 675635013265 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635013266 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635013267 Ubiquitin-like proteins; Region: UBQ; cl00155 675635013268 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 675635013269 active site 675635013270 catalytic residues [active] 675635013271 Protein of unknown function (DUF690); Region: DUF690; cl04939 675635013272 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635013273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635013274 active site 675635013275 phosphorylation site [posttranslational modification] 675635013276 intermolecular recognition site; other site 675635013277 dimerization interface [polypeptide binding]; other site 675635013278 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635013279 DNA binding residues [nucleotide binding] 675635013280 dimerization interface [polypeptide binding]; other site 675635013281 Histidine kinase; Region: HisKA_3; pfam07730 675635013282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635013283 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635013284 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 675635013285 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 675635013286 dimerization interface 3.5A [polypeptide binding]; other site 675635013287 active site 675635013288 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 675635013289 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 675635013290 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 675635013291 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 675635013292 alphaNTD homodimer interface [polypeptide binding]; other site 675635013293 alphaNTD - beta interaction site [polypeptide binding]; other site 675635013294 alphaNTD - beta' interaction site [polypeptide binding]; other site 675635013295 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 675635013296 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 675635013297 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 675635013298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 675635013299 RNA binding surface [nucleotide binding]; other site 675635013300 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 675635013301 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 675635013302 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 675635013303 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 675635013304 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 675635013305 rRNA binding site [nucleotide binding]; other site 675635013306 predicted 30S ribosome binding site; other site 675635013307 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 675635013308 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 675635013309 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 675635013310 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 675635013311 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; pfam01262 675635013312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013313 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 675635013314 active site 675635013315 adenylate kinase; Reviewed; Region: adk; PRK00279 675635013316 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 675635013317 AMP-binding site [chemical binding]; other site 675635013318 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 675635013319 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 675635013320 SecY translocase; Region: SecY; pfam00344 675635013321 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 675635013322 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 675635013323 23S rRNA binding site [nucleotide binding]; other site 675635013324 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 675635013325 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 675635013326 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 675635013327 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 675635013328 5S rRNA interface [nucleotide binding]; other site 675635013329 L27 interface [polypeptide binding]; other site 675635013330 23S rRNA interface [nucleotide binding]; other site 675635013331 L5 interface [polypeptide binding]; other site 675635013332 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 675635013333 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 675635013334 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 675635013335 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 675635013336 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 675635013337 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 675635013338 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 675635013339 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 675635013340 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 675635013341 KOW motif; Region: KOW; cl00354 675635013342 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 675635013343 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 675635013344 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 675635013345 23S rRNA interface [nucleotide binding]; other site 675635013346 putative translocon interaction site; other site 675635013347 signal recognition particle (SRP54) interaction site; other site 675635013348 L23 interface [polypeptide binding]; other site 675635013349 trigger factor interaction site; other site 675635013350 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 675635013351 23S rRNA interface [nucleotide binding]; other site 675635013352 5S rRNA interface [nucleotide binding]; other site 675635013353 putative antibiotic binding site [chemical binding]; other site 675635013354 L25 interface [polypeptide binding]; other site 675635013355 L27 interface [polypeptide binding]; other site 675635013356 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 675635013357 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 675635013358 G-X-X-G motif; other site 675635013359 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 675635013360 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 675635013361 protein-rRNA interface [nucleotide binding]; other site 675635013362 putative translocon binding site; other site 675635013363 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 675635013364 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 675635013365 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 675635013366 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 675635013367 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 675635013368 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 675635013369 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 675635013370 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 675635013371 elongation factor Tu; Reviewed; Region: PRK00049 675635013372 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 675635013373 G1 box; other site 675635013374 GEF interaction site [polypeptide binding]; other site 675635013375 GTP/Mg2+ binding site [chemical binding]; other site 675635013376 Switch I region; other site 675635013377 G2 box; other site 675635013378 G3 box; other site 675635013379 Switch II region; other site 675635013380 G4 box; other site 675635013381 G5 box; other site 675635013382 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 675635013383 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 675635013384 Antibiotic Binding Site [chemical binding]; other site 675635013385 elongation factor G; Reviewed; Region: PRK00007 675635013386 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 675635013387 G1 box; other site 675635013388 putative GEF interaction site [polypeptide binding]; other site 675635013389 GTP/Mg2+ binding site [chemical binding]; other site 675635013390 Switch I region; other site 675635013391 G2 box; other site 675635013392 G3 box; other site 675635013393 Switch II region; other site 675635013394 G4 box; other site 675635013395 G5 box; other site 675635013396 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 675635013397 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 675635013398 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 675635013399 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 675635013400 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 675635013401 S17 interaction site [polypeptide binding]; other site 675635013402 S8 interaction site; other site 675635013403 16S rRNA interaction site [nucleotide binding]; other site 675635013404 streptomycin interaction site [chemical binding]; other site 675635013405 23S rRNA interaction site [nucleotide binding]; other site 675635013406 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 675635013407 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 675635013408 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 675635013409 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 675635013410 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 675635013411 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 675635013412 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 675635013413 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 675635013414 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 675635013415 DNA binding site [nucleotide binding] 675635013416 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 675635013417 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 675635013418 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 675635013419 RPB12 interaction site [polypeptide binding]; other site 675635013420 RPB1 interaction site [polypeptide binding]; other site 675635013421 RPB10 interaction site [polypeptide binding]; other site 675635013422 RPB11 interaction site [polypeptide binding]; other site 675635013423 RPB3 interaction site [polypeptide binding]; other site 675635013424 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 675635013425 AMP-binding enzyme; Region: AMP-binding; cl15778 675635013426 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635013427 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 675635013428 L11 interface [polypeptide binding]; other site 675635013429 putative EF-Tu interaction site [polypeptide binding]; other site 675635013430 putative EF-G interaction site [polypeptide binding]; other site 675635013431 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 675635013432 23S rRNA interface [nucleotide binding]; other site 675635013433 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 675635013434 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 675635013435 mce related protein; Region: MCE; pfam02470 675635013436 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 675635013437 mce related protein; Region: MCE; pfam02470 675635013438 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 675635013439 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 675635013440 mce related protein; Region: MCE; pfam02470 675635013441 mce related protein; Region: MCE; pfam02470 675635013442 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 675635013443 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 675635013444 mce related protein; Region: MCE; pfam02470 675635013445 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 675635013446 mce related protein; Region: MCE; pfam02470 675635013447 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 675635013448 Permease; Region: Permease; cl00510 675635013449 Permease; Region: Permease; cl00510 675635013450 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 675635013451 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 675635013452 Walker A/P-loop; other site 675635013453 ATP binding site [chemical binding]; other site 675635013454 Q-loop/lid; other site 675635013455 ABC transporter signature motif; other site 675635013456 Walker B; other site 675635013457 D-loop; other site 675635013458 H-loop/switch region; other site 675635013459 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 675635013460 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 675635013461 active site 675635013462 diiron metal binding site [ion binding]; other site 675635013463 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 675635013464 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 675635013465 NAD binding site [chemical binding]; other site 675635013466 catalytic Zn binding site [ion binding]; other site 675635013467 substrate binding site [chemical binding]; other site 675635013468 structural Zn binding site [ion binding]; other site 675635013469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635013470 ATP binding site [chemical binding]; other site 675635013471 Mg2+ binding site [ion binding]; other site 675635013472 G-X-G motif; other site 675635013473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635013474 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635013475 phosphorylation site [posttranslational modification] 675635013476 intermolecular recognition site; other site 675635013477 SCP-2 sterol transfer family; Region: SCP2; cl01225 675635013478 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 675635013479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635013480 DNA-binding site [nucleotide binding]; DNA binding site 675635013481 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635013482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635013483 homodimer interface [polypeptide binding]; other site 675635013484 catalytic residue [active] 675635013485 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635013486 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 675635013487 mRNA/rRNA interface [nucleotide binding]; other site 675635013488 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 675635013489 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 675635013490 23S rRNA interface [nucleotide binding]; other site 675635013491 L7/L12 interface [polypeptide binding]; other site 675635013492 putative thiostrepton binding site; other site 675635013493 L25 interface [polypeptide binding]; other site 675635013494 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 675635013495 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 675635013496 putative homodimer interface [polypeptide binding]; other site 675635013497 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 675635013498 aspartate aminotransferase; Provisional; Region: PRK05764 675635013499 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635013500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635013501 homodimer interface [polypeptide binding]; other site 675635013502 catalytic residue [active] 675635013503 Y-family of DNA polymerases; Region: PolY; cl12025 675635013504 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 675635013505 active site 675635013506 catalytic site [active] 675635013507 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 675635013508 active site 675635013509 catalytic site [active] 675635013510 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 675635013511 Sodium:solute symporter family; Region: SSF; cl00456 675635013512 Predicted ATPase [General function prediction only]; Region: COG3899 675635013513 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635013514 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635013515 DNA binding residues [nucleotide binding] 675635013516 dimerization interface [polypeptide binding]; other site 675635013517 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635013518 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 675635013519 AMP-binding enzyme; Region: AMP-binding; cl15778 675635013520 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635013521 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 675635013522 Membrane protein of unknown function; Region: DUF360; cl00850 675635013523 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 675635013524 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635013525 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 675635013526 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 675635013527 nucleophile elbow; other site 675635013528 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635013529 Helix-turn-helix domains; Region: HTH; cl00088 675635013530 Integrase core domain; Region: rve; cl01316 675635013531 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635013532 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 675635013533 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635013534 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 675635013535 CoenzymeA binding site [chemical binding]; other site 675635013536 subunit interaction site [polypeptide binding]; other site 675635013537 PHB binding site; other site 675635013538 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635013539 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 675635013540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635013541 non-specific DNA binding site [nucleotide binding]; other site 675635013542 salt bridge; other site 675635013543 sequence-specific DNA binding site [nucleotide binding]; other site 675635013544 Cupin domain; Region: Cupin_2; cl09118 675635013545 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 675635013546 Domain of unknown function (DUF336); Region: DUF336; cl01249 675635013547 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 675635013548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635013550 Helix-turn-helix domains; Region: HTH; cl00088 675635013551 Helix-turn-helix domains; Region: HTH; cl00088 675635013552 WHG domain; Region: WHG; pfam13305 675635013553 short chain dehydrogenase; Provisional; Region: PRK12937 675635013554 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 675635013555 NADP binding site [chemical binding]; other site 675635013556 homodimer interface [polypeptide binding]; other site 675635013557 active site 675635013558 substrate binding site [chemical binding]; other site 675635013559 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 675635013560 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635013561 DNA binding residues [nucleotide binding] 675635013562 dimer interface [polypeptide binding]; other site 675635013563 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635013564 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635013565 active site 675635013566 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635013567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013568 NAD(P) binding site [chemical binding]; other site 675635013569 active site 675635013570 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635013571 AMP-binding enzyme; Region: AMP-binding; cl15778 675635013572 AMP-binding enzyme; Region: AMP-binding; cl15778 675635013573 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 675635013574 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635013575 dimer interface [polypeptide binding]; other site 675635013576 active site 675635013577 classical (c) SDRs; Region: SDR_c; cd05233 675635013578 NAD(P) binding site [chemical binding]; other site 675635013579 active site 675635013580 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635013581 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635013582 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635013583 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 675635013584 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635013585 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635013586 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 675635013587 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635013588 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635013589 AMP-binding enzyme; Region: AMP-binding; cl15778 675635013590 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 675635013591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635013592 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635013593 classical (c) SDRs; Region: SDR_c; cd05233 675635013594 NAD(P) binding site [chemical binding]; other site 675635013595 active site 675635013596 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635013597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 675635013598 MOSC domain; Region: MOSC; pfam03473 675635013599 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 675635013600 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 675635013601 dimer interface [polypeptide binding]; other site 675635013602 active site 675635013603 heme binding site [chemical binding]; other site 675635013604 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 675635013605 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 675635013606 metal binding site 2 [ion binding]; metal-binding site 675635013607 putative DNA binding helix; other site 675635013608 metal binding site 1 [ion binding]; metal-binding site 675635013609 dimer interface [polypeptide binding]; other site 675635013610 structural Zn2+ binding site [ion binding]; other site 675635013611 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635013612 active site 675635013613 catalytic triad [active] 675635013614 oxyanion hole [active] 675635013615 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635013616 Transcription factor WhiB; Region: Whib; pfam02467 675635013617 TT viral orf 1; Region: TT_ORF1; pfam02956 675635013618 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635013619 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635013620 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635013621 active site 675635013622 catalytic residues [active] 675635013623 DNA binding site [nucleotide binding] 675635013624 Int/Topo IB signature motif; other site 675635013625 Protein of unknown function (DUF520); Region: DUF520; cl00723 675635013626 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 675635013627 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635013628 Transposase domain (DUF772); Region: DUF772; cl15789 675635013629 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635013630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635013631 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 675635013632 Predicted ATPase [General function prediction only]; Region: COG3899 675635013633 TIGR03086 family protein; Region: TIGR03086 675635013634 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635013635 Peptidase family M48; Region: Peptidase_M48; cl12018 675635013636 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 675635013637 CoenzymeA binding site [chemical binding]; other site 675635013638 subunit interaction site [polypeptide binding]; other site 675635013639 PHB binding site; other site 675635013640 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635013641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635013642 substrate binding site [chemical binding]; other site 675635013643 oxyanion hole (OAH) forming residues; other site 675635013644 trimer interface [polypeptide binding]; other site 675635013645 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 675635013646 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 675635013647 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 675635013648 dimer interface [polypeptide binding]; other site 675635013649 PYR/PP interface [polypeptide binding]; other site 675635013650 TPP binding site [chemical binding]; other site 675635013651 substrate binding site [chemical binding]; other site 675635013652 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 675635013653 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 675635013654 TPP-binding site [chemical binding]; other site 675635013655 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 675635013656 ligand binding site [chemical binding]; other site 675635013657 Predicted permeases [General function prediction only]; Region: RarD; COG2962 675635013658 EamA-like transporter family; Region: EamA; cl01037 675635013659 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 675635013660 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 675635013661 substrate binding pocket [chemical binding]; other site 675635013662 chain length determination region; other site 675635013663 substrate-Mg2+ binding site; other site 675635013664 catalytic residues [active] 675635013665 aspartate-rich region 1; other site 675635013666 active site lid residues [active] 675635013667 aspartate-rich region 2; other site 675635013668 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 675635013669 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 675635013670 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 675635013671 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 675635013672 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 675635013673 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 675635013674 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 675635013675 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 675635013676 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 675635013677 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 675635013678 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 675635013679 4Fe-4S binding domain; Region: Fer4; cl02805 675635013680 4Fe-4S binding domain; Region: Fer4; cl02805 675635013681 NADH dehydrogenase; Region: NADHdh; cl00469 675635013682 NADH dehydrogenase subunit G; Validated; Region: PRK07860 675635013683 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635013684 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 675635013685 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635013686 molybdopterin cofactor binding site; other site 675635013687 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 675635013688 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 675635013689 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 675635013690 SLBB domain; Region: SLBB; pfam10531 675635013691 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 675635013692 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 675635013693 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 675635013694 putative dimer interface [polypeptide binding]; other site 675635013695 [2Fe-2S] cluster binding site [ion binding]; other site 675635013696 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 675635013697 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 675635013698 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 675635013699 NADH dehydrogenase subunit B; Validated; Region: PRK06411 675635013700 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 675635013701 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 675635013702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013703 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 675635013704 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 675635013705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635013706 S-adenosylmethionine binding site [chemical binding]; other site 675635013707 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 675635013708 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 675635013709 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 675635013710 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 675635013711 active site 675635013712 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 675635013713 chorismate binding enzyme; Region: Chorismate_bind; cl10555 675635013714 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 675635013715 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635013716 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635013717 DNA binding residues [nucleotide binding] 675635013718 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 675635013719 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 675635013720 MOSC domain; Region: MOSC; pfam03473 675635013721 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 675635013722 lipoyl attachment site [posttranslational modification]; other site 675635013723 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 675635013724 CGNR zinc finger; Region: zf-CGNR; pfam11706 675635013725 Domain of unknown function (DUF427); Region: DUF427; cl00998 675635013726 Domain of unknown function (DUF427); Region: DUF427; cl00998 675635013727 Transposase domain (DUF772); Region: DUF772; cl15789 675635013728 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635013729 Transposase domain (DUF772); Region: DUF772; cl15789 675635013730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 675635013731 MOSC domain; Region: MOSC; pfam03473 675635013732 3-alpha domain; Region: 3-alpha; pfam03475 675635013733 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 675635013734 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 675635013735 FAD binding pocket [chemical binding]; other site 675635013736 FAD binding motif [chemical binding]; other site 675635013737 phosphate binding motif [ion binding]; other site 675635013738 beta-alpha-beta structure motif; other site 675635013739 NAD binding pocket [chemical binding]; other site 675635013740 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635013741 catalytic loop [active] 675635013742 iron binding site [ion binding]; other site 675635013743 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 675635013744 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635013745 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 675635013746 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 675635013747 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 675635013748 dimer interface [polypeptide binding]; other site 675635013749 tetramer interface [polypeptide binding]; other site 675635013750 PYR/PP interface [polypeptide binding]; other site 675635013751 TPP binding site [chemical binding]; other site 675635013752 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635013753 TPP-binding site [chemical binding]; other site 675635013754 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 675635013755 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635013756 inhibitor-cofactor binding pocket; inhibition site 675635013757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635013758 catalytic residue [active] 675635013759 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 675635013760 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 675635013761 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635013762 D-loop; other site 675635013763 H-loop/switch region; other site 675635013764 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 675635013765 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 675635013766 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635013767 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635013768 active site 675635013769 catalytic tetrad [active] 675635013770 Protein of unknown function (DUF998); Region: DUF998; pfam06197 675635013771 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635013772 FAD binding domain; Region: FAD_binding_4; pfam01565 675635013773 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 675635013774 ANTAR domain; Region: ANTAR; cl04297 675635013775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635013776 Coenzyme A binding pocket [chemical binding]; other site 675635013777 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 675635013778 Helix-turn-helix domains; Region: HTH; cl00088 675635013779 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 675635013780 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635013781 substrate binding site [chemical binding]; other site 675635013782 oxyanion hole (OAH) forming residues; other site 675635013783 trimer interface [polypeptide binding]; other site 675635013784 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 675635013785 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 675635013786 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 675635013787 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 675635013788 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635013789 Helicase associated domain (HA2); Region: HA2; cl04503 675635013790 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 675635013791 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 675635013792 AMP-binding enzyme; Region: AMP-binding; cl15778 675635013793 AMP-binding enzyme; Region: AMP-binding; cl15778 675635013794 UbiA prenyltransferase family; Region: UbiA; cl00337 675635013795 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 675635013796 DNA binding residues [nucleotide binding] 675635013797 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 675635013798 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 675635013799 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 675635013800 ResB-like family; Region: ResB; pfam05140 675635013801 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 675635013802 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 675635013803 catalytic residues [active] 675635013804 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 675635013805 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635013806 catalytic core [active] 675635013807 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 675635013808 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635013809 inhibitor-cofactor binding pocket; inhibition site 675635013810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635013811 catalytic residue [active] 675635013812 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 675635013813 RDD family; Region: RDD; cl00746 675635013814 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 675635013815 dimer interface [polypeptide binding]; other site 675635013816 active site 675635013817 Schiff base residues; other site 675635013818 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 675635013819 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 675635013820 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 675635013821 active site 675635013822 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 675635013823 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 675635013824 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 675635013825 domain interfaces; other site 675635013826 active site 675635013827 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 675635013828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013829 NAD(P) binding pocket [chemical binding]; other site 675635013830 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 675635013831 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 675635013832 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 675635013833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013834 Fasciclin domain; Region: Fasciclin; cl02663 675635013835 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 675635013836 Moco binding site; other site 675635013837 metal coordination site [ion binding]; other site 675635013838 dimerization interface [polypeptide binding]; other site 675635013839 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635013840 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 675635013841 AMP-binding enzyme; Region: AMP-binding; cl15778 675635013842 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635013843 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 675635013844 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635013845 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635013846 DNA binding residues [nucleotide binding] 675635013847 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635013848 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 675635013849 putative acyl-acceptor binding pocket; other site 675635013850 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 675635013851 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635013852 putative NAD(P) binding site [chemical binding]; other site 675635013853 active site 675635013854 putative substrate binding site [chemical binding]; other site 675635013855 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635013856 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 675635013857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013859 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635013860 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 675635013861 active site 2 [active] 675635013862 active site 1 [active] 675635013863 Proline dehydrogenase; Region: Pro_dh; cl03282 675635013864 Proline dehydrogenase; Region: Pro_dh; cl03282 675635013865 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 675635013866 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 675635013867 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635013868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635013869 active site 675635013870 phosphorylation site [posttranslational modification] 675635013871 intermolecular recognition site; other site 675635013872 dimerization interface [polypeptide binding]; other site 675635013873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635013874 DNA binding site [nucleotide binding] 675635013875 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635013876 dimer interface [polypeptide binding]; other site 675635013877 phosphorylation site [posttranslational modification] 675635013878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635013879 ATP binding site [chemical binding]; other site 675635013880 Mg2+ binding site [ion binding]; other site 675635013881 G-X-G motif; other site 675635013882 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635013883 catalytic core [active] 675635013884 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 675635013885 Helix-turn-helix domains; Region: HTH; cl00088 675635013886 Helix-turn-helix domains; Region: HTH; cl00088 675635013887 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635013888 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635013889 active site 675635013890 metal binding site [ion binding]; metal-binding site 675635013891 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 675635013892 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 675635013893 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 675635013894 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 675635013895 putative ADP-binding pocket [chemical binding]; other site 675635013896 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 675635013897 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 675635013898 H+ Antiporter protein; Region: 2A0121; TIGR00900 675635013899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635013900 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 675635013901 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 675635013902 DNA-binding site [nucleotide binding]; DNA binding site 675635013903 RNA-binding motif; other site 675635013904 AMP-binding domain protein; Validated; Region: PRK08315 675635013905 AMP-binding enzyme; Region: AMP-binding; cl15778 675635013906 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635013907 seryl-tRNA synthetase; Provisional; Region: PRK05431 675635013908 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 675635013909 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 675635013910 dimer interface [polypeptide binding]; other site 675635013911 active site 675635013912 motif 1; other site 675635013913 motif 2; other site 675635013914 motif 3; other site 675635013915 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 675635013916 calcium binding site 2 [ion binding]; other site 675635013917 active site 675635013918 catalytic triad [active] 675635013919 calcium binding site 1 [ion binding]; other site 675635013920 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 675635013921 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635013922 Walker A/P-loop; other site 675635013923 ATP binding site [chemical binding]; other site 675635013924 Q-loop/lid; other site 675635013925 ABC transporter signature motif; other site 675635013926 Walker B; other site 675635013927 D-loop; other site 675635013928 H-loop/switch region; other site 675635013929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635013930 putative PBP binding loops; other site 675635013931 ABC-ATPase subunit interface; other site 675635013932 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 675635013933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635013934 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635013935 DNA binding residues [nucleotide binding] 675635013936 TOBE domain; Region: TOBE_2; cl01440 675635013937 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635013938 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635013939 active site 675635013940 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 675635013941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635013942 FeS/SAM binding site; other site 675635013943 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 675635013944 Ubiquitin-like proteins; Region: UBQ; cl00155 675635013945 charged pocket; other site 675635013946 hydrophobic patch; other site 675635013947 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 675635013948 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 675635013949 cleavage site 675635013950 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 675635013951 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635013952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635013953 active site 675635013954 phosphorylation site [posttranslational modification] 675635013955 intermolecular recognition site; other site 675635013956 dimerization interface [polypeptide binding]; other site 675635013957 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635013958 DNA binding site [nucleotide binding] 675635013959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635013960 dimer interface [polypeptide binding]; other site 675635013961 phosphorylation site [posttranslational modification] 675635013962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635013963 ATP binding site [chemical binding]; other site 675635013964 Mg2+ binding site [ion binding]; other site 675635013965 G-X-G motif; other site 675635013966 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 675635013967 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 675635013968 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 675635013969 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635013970 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 675635013971 putative hydrophobic ligand binding site [chemical binding]; other site 675635013972 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635013973 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635013974 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 675635013975 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635013976 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635013977 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635013978 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635013979 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635013980 mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965 675635013981 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635013982 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 675635013983 Creatinine amidohydrolase; Region: Creatininase; cl00618 675635013984 mycofactocin system FadH/OYE family oxidoreductase 1; Region: mycofact_OYE_1; TIGR03996 675635013985 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635013986 phosphate binding site [ion binding]; other site 675635013987 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 675635013988 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635013989 phosphate binding site [ion binding]; other site 675635013990 mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962 675635013991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635013992 FeS/SAM binding site; other site 675635013993 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 675635013994 mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967 675635013995 Protein of unknown function (DUF952); Region: DUF952; cl01393 675635013996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013997 NAD(P) binding site [chemical binding]; other site 675635013998 active site 675635013999 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635014000 classical (c) SDRs; Region: SDR_c; cd05233 675635014001 NAD(P) binding site [chemical binding]; other site 675635014002 active site 675635014003 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 675635014004 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635014005 phosphate binding site [ion binding]; other site 675635014006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635014007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635014008 ATP binding site [chemical binding]; other site 675635014009 Mg2+ binding site [ion binding]; other site 675635014010 G-X-G motif; other site 675635014011 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635014012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635014013 active site 675635014014 phosphorylation site [posttranslational modification] 675635014015 intermolecular recognition site; other site 675635014016 dimerization interface [polypeptide binding]; other site 675635014017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635014018 DNA binding residues [nucleotide binding] 675635014019 dimerization interface [polypeptide binding]; other site 675635014020 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 675635014021 active site 675635014022 catalytic residues [active] 675635014023 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 675635014024 NodB motif; other site 675635014025 active site 675635014026 catalytic site [active] 675635014027 metal binding site [ion binding]; metal-binding site 675635014028 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 675635014029 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 675635014030 DXD motif; other site 675635014031 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 675635014032 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 675635014033 FAD binding domain; Region: FAD_binding_4; pfam01565 675635014034 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635014035 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635014036 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635014037 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635014038 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635014039 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635014040 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 675635014041 dimer interface [polypeptide binding]; other site 675635014042 substrate binding site [chemical binding]; other site 675635014043 ATP binding site [chemical binding]; other site 675635014044 Domain of unknown function (DUF385); Region: DUF385; cl04387 675635014045 FtsX-like permease family; Region: FtsX; cl15850 675635014046 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 675635014047 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 675635014048 Walker A/P-loop; other site 675635014049 ATP binding site [chemical binding]; other site 675635014050 Q-loop/lid; other site 675635014051 ABC transporter signature motif; other site 675635014052 Walker B; other site 675635014053 D-loop; other site 675635014054 H-loop/switch region; other site 675635014055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635014056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635014057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635014058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635014059 active site 675635014060 phosphorylation site [posttranslational modification] 675635014061 intermolecular recognition site; other site 675635014062 dimerization interface [polypeptide binding]; other site 675635014063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635014064 DNA binding residues [nucleotide binding] 675635014065 dimerization interface [polypeptide binding]; other site 675635014066 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 675635014067 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635014068 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 675635014069 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 675635014070 active site 675635014071 catalytic residues [active] 675635014072 metal binding site [ion binding]; metal-binding site 675635014073 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 675635014074 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 675635014075 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 675635014076 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 675635014077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635014078 Walker A motif; other site 675635014079 ATP binding site [chemical binding]; other site 675635014080 Walker B motif; other site 675635014081 arginine finger; other site 675635014082 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 675635014083 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 675635014084 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 675635014085 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 675635014086 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 675635014087 dimer interface [polypeptide binding]; other site 675635014088 putative functional site; other site 675635014089 putative MPT binding site; other site 675635014090 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 675635014091 DNA-binding site [nucleotide binding]; DNA binding site 675635014092 RNA-binding motif; other site 675635014093 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 675635014094 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 675635014095 ring oligomerisation interface [polypeptide binding]; other site 675635014096 ATP/Mg binding site [chemical binding]; other site 675635014097 stacking interactions; other site 675635014098 hinge regions; other site 675635014099 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635014100 Helix-turn-helix domains; Region: HTH; cl00088 675635014101 WYL domain; Region: WYL; cl14852 675635014102 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635014103 TIGR03086 family protein; Region: TIGR03086 675635014104 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 675635014105 PspC domain; Region: PspC; cl00864 675635014106 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 675635014107 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 675635014108 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635014109 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635014110 ATP binding site [chemical binding]; other site 675635014111 putative Mg++ binding site [ion binding]; other site 675635014112 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635014113 nucleotide binding region [chemical binding]; other site 675635014114 ATP-binding site [chemical binding]; other site 675635014115 Nitrate and nitrite sensing; Region: NIT; pfam08376 675635014116 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 675635014117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635014118 ATP binding site [chemical binding]; other site 675635014119 Mg2+ binding site [ion binding]; other site 675635014120 G-X-G motif; other site 675635014121 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 675635014122 Protein of unknown function (DUF742); Region: DUF742; pfam05331 675635014123 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 675635014124 G2 box; other site 675635014125 Switch I region; other site 675635014126 G3 box; other site 675635014127 Switch II region; other site 675635014128 GTP/Mg2+ binding site [chemical binding]; other site 675635014129 G4 box; other site 675635014130 G5 box; other site 675635014131 AAA domain; Region: AAA_33; pfam13671 675635014132 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635014133 active site 675635014134 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 675635014135 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 675635014136 metal-binding site 675635014137 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 675635014138 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 675635014139 putative peptidoglycan binding site; other site 675635014140 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 675635014141 trimer interface [polypeptide binding]; other site 675635014142 dimer interface [polypeptide binding]; other site 675635014143 putative active site [active] 675635014144 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 675635014145 MPT binding site; other site 675635014146 trimer interface [polypeptide binding]; other site 675635014147 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 675635014148 MoaE homodimer interface [polypeptide binding]; other site 675635014149 MoaD interaction [polypeptide binding]; other site 675635014150 active site residues [active] 675635014151 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 675635014152 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 675635014153 putative peptidoglycan binding site; other site 675635014154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635014155 Walker A motif; other site 675635014156 ATP binding site [chemical binding]; other site 675635014157 Walker B motif; other site 675635014158 arginine finger; other site 675635014159 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 675635014160 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 675635014161 metal ion-dependent adhesion site (MIDAS); other site 675635014162 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 675635014163 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 675635014164 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 675635014165 XdhC Rossmann domain; Region: XdhC_C; pfam13478 675635014166 Sporulation and spore germination; Region: Germane; cl11253 675635014167 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 675635014168 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 675635014169 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 675635014170 trimer interface [polypeptide binding]; other site 675635014171 putative metal binding site [ion binding]; other site 675635014172 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 675635014173 ThiS interaction site; other site 675635014174 putative active site [active] 675635014175 tetramer interface [polypeptide binding]; other site 675635014176 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 675635014177 thiS-thiF/thiG interaction site; other site 675635014178 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 675635014179 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 675635014180 active site 675635014181 thiamine phosphate binding site [chemical binding]; other site 675635014182 pyrophosphate binding site [ion binding]; other site 675635014183 CUT domain; Region: CUT; pfam02376 675635014184 LexA repressor; Validated; Region: PRK00215 675635014185 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635014186 Helix-turn-helix domains; Region: HTH; cl00088 675635014187 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635014188 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 675635014189 Phage Terminase; Region: Terminase_1; pfam03354 675635014190 Protein of unknown function (DUF935); Region: DUF935; pfam06074 675635014191 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 675635014192 oligomer interface [polypeptide binding]; other site 675635014193 active site residues [active] 675635014194 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 675635014195 oligomerization interface [polypeptide binding]; other site 675635014196 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 675635014197 NlpC/P60 family; Region: NLPC_P60; cl11438 675635014198 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635014199 DNA binding residues [nucleotide binding] 675635014200 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635014201 active site 675635014202 catalytic residues [active] 675635014203 DNA binding site [nucleotide binding] 675635014204 Int/Topo IB signature motif; other site 675635014205 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 675635014206 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 675635014207 active site 675635014208 catalytic triad [active] 675635014209 oxyanion hole [active] 675635014210 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 675635014211 Cupin domain; Region: Cupin_2; cl09118 675635014212 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 675635014213 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635014214 inhibitor-cofactor binding pocket; inhibition site 675635014215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635014216 catalytic residue [active] 675635014217 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 675635014218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635014219 Coenzyme A binding pocket [chemical binding]; other site 675635014220 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635014221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635014222 hypothetical protein; Provisional; Region: PRK11770 675635014223 Domain of unknown function (DUF307); Region: DUF307; pfam03733 675635014224 Domain of unknown function (DUF307); Region: DUF307; pfam03733 675635014225 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 675635014226 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 675635014227 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 675635014228 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 675635014229 Domain of unknown function (DUF427); Region: DUF427; cl00998 675635014230 Phosphate transporter family; Region: PHO4; cl00396 675635014231 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 675635014232 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635014233 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635014234 active site 675635014235 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635014236 non-prolyl cis peptide bond; other site 675635014237 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635014238 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 675635014239 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635014240 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635014241 putative NAD(P) binding site [chemical binding]; other site 675635014242 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 675635014243 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 675635014244 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 675635014245 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635014246 Helix-turn-helix domains; Region: HTH; cl00088 675635014247 Integrase core domain; Region: rve; cl01316 675635014248 Putative zinc-finger; Region: zf-HC2; cl15806 675635014249 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 675635014250 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635014251 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635014252 DNA binding residues [nucleotide binding] 675635014253 DsrE/DsrF-like family; Region: DrsE; cl00672 675635014254 squalene epoxidase; Provisional; Region: PTZ00367 675635014255 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 675635014256 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635014257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635014258 DNA binding site [nucleotide binding] 675635014259 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 675635014260 Predicted ATPase [General function prediction only]; Region: COG3899 675635014261 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 675635014262 Predicted ATPase [General function prediction only]; Region: COG3899 675635014263 Integral membrane protein TerC family; Region: TerC; cl10468 675635014264 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635014265 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 675635014266 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635014267 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635014268 Predicted esterase [General function prediction only]; Region: COG0400 675635014269 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635014270 DNA-binding site [nucleotide binding]; DNA binding site 675635014271 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635014272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635014273 homodimer interface [polypeptide binding]; other site 675635014274 catalytic residue [active] 675635014275 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635014276 hypothetical protein; Provisional; Region: PRK08317 675635014277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635014278 S-adenosylmethionine binding site [chemical binding]; other site 675635014279 amidase; Provisional; Region: PRK07869 675635014280 Amidase; Region: Amidase; cl11426 675635014281 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635014282 K+ potassium transporter; Region: K_trans; cl15781 675635014283 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635014284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635014285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635014286 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 675635014287 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635014288 catalytic Zn binding site [ion binding]; other site 675635014289 structural Zn binding site [ion binding]; other site 675635014290 tetramer interface [polypeptide binding]; other site 675635014291 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 675635014292 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 675635014293 D-pathway; other site 675635014294 Putative ubiquinol binding site [chemical binding]; other site 675635014295 Low-spin heme (heme b) binding site [chemical binding]; other site 675635014296 Putative water exit pathway; other site 675635014297 Binuclear center (heme o3/CuB) [ion binding]; other site 675635014298 K-pathway; other site 675635014299 Putative proton exit pathway; other site 675635014300 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 675635014301 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 675635014302 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 675635014303 Helix-turn-helix domains; Region: HTH; cl00088 675635014304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 675635014305 Bacterial Ig-like domain; Region: Big_5; cl01012 675635014306 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 675635014307 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 675635014308 FMN binding site [chemical binding]; other site 675635014309 substrate binding site [chemical binding]; other site 675635014310 putative catalytic residue [active] 675635014311 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 675635014312 putative hydrophobic ligand binding site [chemical binding]; other site 675635014313 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635014314 dimerization interface [polypeptide binding]; other site 675635014315 putative DNA binding site [nucleotide binding]; other site 675635014316 putative Zn2+ binding site [ion binding]; other site 675635014317 Dehydratase family; Region: ILVD_EDD; cl00340 675635014318 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 675635014319 heme binding pocket [chemical binding]; other site 675635014320 heme ligand [chemical binding]; other site 675635014321 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 675635014322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635014323 Helix-turn-helix domains; Region: HTH; cl00088 675635014324 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635014325 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635014326 active site 675635014327 metal binding site [ion binding]; metal-binding site 675635014328 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635014329 Helix-turn-helix domains; Region: HTH; cl00088 675635014330 WYL domain; Region: WYL; cl14852 675635014331 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635014332 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 675635014333 Amidohydrolase; Region: Amidohydro_4; pfam13147 675635014334 active site 675635014335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635014336 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635014337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635014338 DNA binding residues [nucleotide binding] 675635014339 dimerization interface [polypeptide binding]; other site 675635014340 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635014341 Cytochrome P450; Region: p450; pfam00067 675635014342 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 675635014343 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 675635014344 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 675635014345 FAD binding pocket [chemical binding]; other site 675635014346 FAD binding motif [chemical binding]; other site 675635014347 catalytic residues [active] 675635014348 NAD binding pocket [chemical binding]; other site 675635014349 phosphate binding motif [ion binding]; other site 675635014350 beta-alpha-beta structure motif; other site 675635014351 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 675635014352 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 675635014353 [2Fe-2S] cluster binding site [ion binding]; other site 675635014354 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635014355 hydrophobic ligand binding site; other site 675635014356 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 675635014357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635014358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635014359 Helix-turn-helix domains; Region: HTH; cl00088 675635014360 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635014361 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635014362 Right handed beta helix region; Region: Beta_helix; pfam13229 675635014363 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 675635014364 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635014365 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 675635014366 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635014367 inhibitor-cofactor binding pocket; inhibition site 675635014368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635014369 catalytic residue [active] 675635014370 Cupin domain; Region: Cupin_2; cl09118 675635014371 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635014372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635014373 DNA-binding site [nucleotide binding]; DNA binding site 675635014374 FCD domain; Region: FCD; cl11656 675635014375 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 675635014376 AMP-binding enzyme; Region: AMP-binding; cl15778 675635014377 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635014378 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635014379 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 675635014380 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 675635014381 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 675635014382 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635014383 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635014384 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 675635014385 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635014386 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635014387 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 675635014388 dimer interface [polypeptide binding]; other site 675635014389 active site 675635014390 feruloyl-CoA synthase; Reviewed; Region: PRK08180 675635014391 AMP-binding enzyme; Region: AMP-binding; cl15778 675635014392 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 675635014393 NodB motif; other site 675635014394 active site 675635014395 catalytic site [active] 675635014396 metal binding site [ion binding]; metal-binding site 675635014397 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 675635014398 Moco binding site; other site 675635014399 metal coordination site [ion binding]; other site 675635014400 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 675635014401 FAD binding pocket [chemical binding]; other site 675635014402 conserved FAD binding motif [chemical binding]; other site 675635014403 phosphate binding motif [ion binding]; other site 675635014404 beta-alpha-beta structure motif; other site 675635014405 NAD binding pocket [chemical binding]; other site 675635014406 Carboxylesterase family; Region: COesterase; pfam00135 675635014407 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635014408 substrate binding pocket [chemical binding]; other site 675635014409 catalytic triad [active] 675635014410 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 675635014411 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 675635014412 Cation efflux family; Region: Cation_efflux; cl00316 675635014413 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 675635014414 AMP-binding enzyme; Region: AMP-binding; cl15778 675635014415 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635014416 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 675635014417 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635014418 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635014419 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635014420 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635014421 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 675635014422 putative hydrophobic ligand binding site [chemical binding]; other site 675635014423 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 675635014424 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635014425 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635014426 enoyl-CoA hydratase; Provisional; Region: PRK07658 675635014427 substrate binding site [chemical binding]; other site 675635014428 oxyanion hole (OAH) forming residues; other site 675635014429 trimer interface [polypeptide binding]; other site 675635014430 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635014431 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635014432 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635014433 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635014434 AMP-binding enzyme; Region: AMP-binding; cl15778 675635014435 AMP-binding enzyme; Region: AMP-binding; cl15778 675635014436 Helix-turn-helix domains; Region: HTH; cl00088 675635014437 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 675635014438 putative catalytic residues [active] 675635014439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635014440 Helix-turn-helix domains; Region: HTH; cl00088 675635014441 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 675635014442 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635014443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635014444 NAD(P) binding site [chemical binding]; other site 675635014445 active site 675635014446 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 675635014447 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 675635014448 Ligand binding site; other site 675635014449 Putative Catalytic site; other site 675635014450 DXD motif; other site 675635014451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635014452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635014453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635014454 dimer interface [polypeptide binding]; other site 675635014455 phosphorylation site [posttranslational modification] 675635014456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635014457 ATP binding site [chemical binding]; other site 675635014458 Mg2+ binding site [ion binding]; other site 675635014459 G-X-G motif; other site 675635014460 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635014461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635014462 active site 675635014463 phosphorylation site [posttranslational modification] 675635014464 intermolecular recognition site; other site 675635014465 dimerization interface [polypeptide binding]; other site 675635014466 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635014467 DNA binding site [nucleotide binding] 675635014468 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 675635014469 Moco binding site; other site 675635014470 metal coordination site [ion binding]; other site 675635014471 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635014472 Amidase; Region: Amidase; cl11426 675635014473 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635014474 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 675635014475 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 675635014476 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 675635014477 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 675635014478 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635014479 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635014480 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635014481 dimerization interface [polypeptide binding]; other site 675635014482 putative DNA binding site [nucleotide binding]; other site 675635014483 putative Zn2+ binding site [ion binding]; other site 675635014484 Winged helix-turn helix; Region: HTH_29; pfam13551 675635014485 Helix-turn-helix domains; Region: HTH; cl00088 675635014486 Integrase core domain; Region: rve; cl01316 675635014487 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 675635014488 4Fe-4S binding domain; Region: Fer4; cl02805 675635014489 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 675635014490 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 675635014491 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 675635014492 Walker A/P-loop; other site 675635014493 ATP binding site [chemical binding]; other site 675635014494 Q-loop/lid; other site 675635014495 ABC transporter signature motif; other site 675635014496 Walker B; other site 675635014497 D-loop; other site 675635014498 H-loop/switch region; other site 675635014499 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 675635014500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635014501 putative PBP binding loops; other site 675635014502 dimer interface [polypeptide binding]; other site 675635014503 ABC-ATPase subunit interface; other site 675635014504 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 675635014505 NMT1-like family; Region: NMT1_2; cl15260 675635014506 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 675635014507 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 675635014508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635014509 DNA-binding site [nucleotide binding]; DNA binding site 675635014510 UTRA domain; Region: UTRA; cl01230 675635014511 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635014512 hydrophobic ligand binding site; other site 675635014513 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 675635014514 Helix-turn-helix domains; Region: HTH; cl00088 675635014515 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 675635014516 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635014517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635014518 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 675635014519 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635014520 active site 675635014521 catalytic tetrad [active] 675635014522 Predicted acyl esterases [General function prediction only]; Region: COG2936 675635014523 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 675635014524 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635014525 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635014526 Helix-turn-helix domains; Region: HTH; cl00088 675635014527 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635014528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635014529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635014530 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635014531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635014532 putative substrate translocation pore; other site 675635014533 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635014534 Peptidase family M48; Region: Peptidase_M48; cl12018 675635014535 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 675635014536 Short C-terminal domain; Region: SHOCT; cl01373 675635014537 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 675635014538 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635014539 DNA binding residues [nucleotide binding] 675635014540 amidase; Provisional; Region: PRK07869 675635014541 Amidase; Region: Amidase; cl11426 675635014542 TIGR03086 family protein; Region: TIGR03086 675635014543 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 675635014544 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 675635014545 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635014546 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 675635014547 Helix-turn-helix domains; Region: HTH; cl00088 675635014548 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 675635014549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635014550 NAD(P) binding site [chemical binding]; other site 675635014551 active site 675635014552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635014553 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635014554 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635014555 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635014556 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 675635014557 putative ligand binding site [chemical binding]; other site 675635014558 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635014559 Helix-turn-helix domains; Region: HTH; cl00088 675635014560 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 675635014561 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635014562 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 675635014563 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 675635014564 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635014565 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 675635014566 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 675635014567 Cupin domain; Region: Cupin_2; cl09118 675635014568 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635014569 Helix-turn-helix domains; Region: HTH; cl00088 675635014570 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 675635014571 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635014572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635014573 homodimer interface [polypeptide binding]; other site 675635014574 catalytic residue [active] 675635014575 aspartate aminotransferase; Provisional; Region: PRK05764 675635014576 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635014577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635014578 homodimer interface [polypeptide binding]; other site 675635014579 catalytic residue [active] 675635014580 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635014581 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 675635014582 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635014583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635014584 dimer interface [polypeptide binding]; other site 675635014585 conserved gate region; other site 675635014586 putative PBP binding loops; other site 675635014587 ABC-ATPase subunit interface; other site 675635014588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635014589 dimer interface [polypeptide binding]; other site 675635014590 conserved gate region; other site 675635014591 putative PBP binding loops; other site 675635014592 ABC-ATPase subunit interface; other site 675635014593 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635014594 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635014595 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635014596 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 675635014597 active site 675635014598 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 675635014599 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635014600 Walker A/P-loop; other site 675635014601 ATP binding site [chemical binding]; other site 675635014602 Q-loop/lid; other site 675635014603 ABC transporter signature motif; other site 675635014604 Walker B; other site 675635014605 D-loop; other site 675635014606 H-loop/switch region; other site 675635014607 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635014608 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 675635014609 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635014610 Walker A/P-loop; other site 675635014611 ATP binding site [chemical binding]; other site 675635014612 Q-loop/lid; other site 675635014613 ABC transporter signature motif; other site 675635014614 Walker B; other site 675635014615 D-loop; other site 675635014616 H-loop/switch region; other site 675635014617 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635014618 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635014619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635014620 active site 675635014621 phosphorylation site [posttranslational modification] 675635014622 intermolecular recognition site; other site 675635014623 dimerization interface [polypeptide binding]; other site 675635014624 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635014625 DNA binding site [nucleotide binding] 675635014626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635014627 dimer interface [polypeptide binding]; other site 675635014628 phosphorylation site [posttranslational modification] 675635014629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635014630 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 675635014631 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 675635014632 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 675635014633 putative active site pocket [active] 675635014634 putative metal binding site [ion binding]; other site 675635014635 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 675635014636 thiamine pyrophosphate protein; Provisional; Region: PRK08273 675635014637 PYR/PP interface [polypeptide binding]; other site 675635014638 dimer interface [polypeptide binding]; other site 675635014639 tetramer interface [polypeptide binding]; other site 675635014640 TPP binding site [chemical binding]; other site 675635014641 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 675635014642 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 675635014643 TPP-binding site [chemical binding]; other site 675635014644 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635014645 FAD binding domain; Region: FAD_binding_4; pfam01565 675635014646 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 675635014647 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 675635014648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635014649 NAD(P) binding site [chemical binding]; other site 675635014650 active site 675635014651 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 675635014652 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 675635014653 Response regulator receiver domain; Region: Response_reg; pfam00072 675635014654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635014655 active site 675635014656 phosphorylation site [posttranslational modification] 675635014657 intermolecular recognition site; other site 675635014658 dimerization interface [polypeptide binding]; other site 675635014659 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635014660 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635014661 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635014662 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635014663 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 675635014664 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 675635014665 active site 675635014666 metal binding site [ion binding]; metal-binding site 675635014667 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635014668 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635014669 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635014670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635014671 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635014672 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635014673 transposase/IS protein; Provisional; Region: PRK09183 675635014674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635014675 Walker A motif; other site 675635014676 ATP binding site [chemical binding]; other site 675635014677 Walker B motif; other site 675635014678 arginine finger; other site 675635014679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635014680 Integrase core domain; Region: rve; cl01316 675635014681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635014682 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 675635014683 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635014684 active site 675635014685 DNA binding site [nucleotide binding] 675635014686 Int/Topo IB signature motif; other site 675635014687 Winged helix-turn helix; Region: HTH_29; pfam13551 675635014688 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635014689 Helix-turn-helix domains; Region: HTH; cl00088 675635014690 Integrase core domain; Region: rve; cl01316 675635014691 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635014692 MULE transposase domain; Region: MULE; pfam10551 675635014693 amidase; Provisional; Region: PRK07487 675635014694 Amidase; Region: Amidase; cl11426 675635014695 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635014696 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635014697 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635014698 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 675635014699 active site 675635014700 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 675635014701 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635014702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635014703 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635014704 NAD(P) binding site [chemical binding]; other site 675635014705 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 675635014706 dimerization interface [polypeptide binding]; other site 675635014707 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635014708 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 675635014709 [2Fe-2S] cluster binding site [ion binding]; other site 675635014710 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 675635014711 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 675635014712 dimerization interface [polypeptide binding]; other site 675635014713 putative path to active site cavity [active] 675635014714 diiron center [ion binding]; other site 675635014715 Muconolactone delta-isomerase; Region: MIase; cl01992 675635014716 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 675635014717 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635014718 metal binding site [ion binding]; metal-binding site 675635014719 substrate binding pocket [chemical binding]; other site 675635014720 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 675635014721 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635014722 active site 675635014723 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 675635014724 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 675635014725 Flavin Reductases; Region: FlaRed; cl00801 675635014726 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 675635014727 Helix-turn-helix domains; Region: HTH; cl00088 675635014728 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635014729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635014730 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13104 675635014731 TIGR03809 family protein; Region: TIGR03809 675635014732 AAA domain; Region: AAA_31; pfam13614 675635014733 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635014734 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 675635014735 P loop; other site 675635014736 P-loop; other site 675635014737 Nucleotide binding site [chemical binding]; other site 675635014738 Magnesium ion binding site [ion binding]; other site 675635014739 DTAP/Switch II; other site 675635014740 Switch I; other site 675635014741 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 675635014742 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 675635014743 active site 675635014744 catalytic residues [active] 675635014745 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635014746 active site 675635014747 catalytic residues [active] 675635014748 DNA binding site [nucleotide binding] 675635014749 Int/Topo IB signature motif; other site 675635014750 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cd00397 675635014751 active site 675635014752 DNA binding site [nucleotide binding] 675635014753 Int/Topo IB signature motif; other site 675635014754 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635014755 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635014756 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635014757 active site 675635014758 DNA binding site [nucleotide binding] 675635014759 Int/Topo IB signature motif; other site 675635014760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635014761 DNA-binding site [nucleotide binding]; DNA binding site 675635014762 ABC-2 type transporter; Region: ABC2_membrane; cl11417 675635014763 Uncharacterized conserved protein [Function unknown]; Region: COG2966 675635014764 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 675635014765 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 675635014766 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 675635014767 active site 675635014768 homotetramer interface [polypeptide binding]; other site 675635014769 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635014770 Transcriptional regulators [Transcription]; Region: PurR; COG1609 675635014771 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 675635014772 DNA binding site [nucleotide binding] 675635014773 domain linker motif; other site 675635014774 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 675635014775 putative dimerization interface [polypeptide binding]; other site 675635014776 putative ligand binding site [chemical binding]; other site 675635014777 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 675635014778 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 675635014779 intersubunit interface [polypeptide binding]; other site 675635014780 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 675635014781 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635014782 Walker A/P-loop; other site 675635014783 ATP binding site [chemical binding]; other site 675635014784 Q-loop/lid; other site 675635014785 ABC transporter signature motif; other site 675635014786 Walker B; other site 675635014787 D-loop; other site 675635014788 H-loop/switch region; other site 675635014789 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 675635014790 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 675635014791 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 675635014792 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 675635014793 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635014794 active site 675635014795 HIGH motif; other site 675635014796 nucleotide binding site [chemical binding]; other site 675635014797 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 675635014798 KMSKS motif; other site 675635014799 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 675635014800 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 675635014801 putative dimer interface [polypeptide binding]; other site 675635014802 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030 675635014803 homotrimer interaction site [polypeptide binding]; other site 675635014804 zinc binding site [ion binding]; other site 675635014805 CDP-binding sites; other site 675635014806 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 675635014807 substrate binding site; other site 675635014808 dimer interface; other site 675635014809 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 675635014810 Protein of unknown function (DUF461); Region: DUF461; cl01071 675635014811 DNA repair protein RadA; Provisional; Region: PRK11823 675635014812 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635014813 Walker A motif; other site 675635014814 ATP binding site [chemical binding]; other site 675635014815 Walker B motif; other site 675635014816 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 675635014817 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 675635014818 minor groove reading motif; other site 675635014819 helix-hairpin-helix signature motif; other site 675635014820 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 675635014821 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635014822 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635014823 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 675635014824 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 675635014825 Clp protease ATP binding subunit; Region: clpC; CHL00095 675635014826 Clp amino terminal domain; Region: Clp_N; pfam02861 675635014827 Clp amino terminal domain; Region: Clp_N; pfam02861 675635014828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635014829 Walker A motif; other site 675635014830 ATP binding site [chemical binding]; other site 675635014831 Walker B motif; other site 675635014832 arginine finger; other site 675635014833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 675635014834 UvrB/uvrC motif; Region: UVR; pfam02151 675635014835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635014836 Walker A motif; other site 675635014837 ATP binding site [chemical binding]; other site 675635014838 Walker B motif; other site 675635014839 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 675635014840 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 675635014841 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 675635014842 FAD binding pocket [chemical binding]; other site 675635014843 FAD binding motif [chemical binding]; other site 675635014844 phosphate binding motif [ion binding]; other site 675635014845 NAD binding pocket [chemical binding]; other site 675635014846 Lsr2; Region: Lsr2; pfam11774 675635014847 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 675635014848 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 675635014849 dimer interface [polypeptide binding]; other site 675635014850 putative anticodon binding site; other site 675635014851 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 675635014852 motif 1; other site 675635014853 dimer interface [polypeptide binding]; other site 675635014854 active site 675635014855 motif 2; other site 675635014856 motif 3; other site 675635014857 Type III pantothenate kinase; Region: Pan_kinase; cl09130 675635014858 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 675635014859 tetramerization interface [polypeptide binding]; other site 675635014860 active site 675635014861 pantoate--beta-alanine ligase; Region: panC; TIGR00018 675635014862 Pantoate-beta-alanine ligase; Region: PanC; cd00560 675635014863 active site 675635014864 ATP-binding site [chemical binding]; other site 675635014865 pantoate-binding site; other site 675635014866 HXXH motif; other site 675635014867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635014868 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 675635014869 Protease prsW family; Region: PrsW-protease; cl15823 675635014870 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 675635014871 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 675635014872 catalytic center binding site [active] 675635014873 ATP binding site [chemical binding]; other site 675635014874 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 675635014875 homooctamer interface [polypeptide binding]; other site 675635014876 active site 675635014877 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 675635014878 substrate binding pocket [chemical binding]; other site 675635014879 inhibitor binding site; inhibition site 675635014880 GTP cyclohydrolase I; Provisional; Region: PLN03044 675635014881 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 675635014882 homodecamer interface [polypeptide binding]; other site 675635014883 active site 675635014884 putative catalytic site residues [active] 675635014885 zinc binding site [ion binding]; other site 675635014886 GTP-CH-I/GFRP interaction surface; other site 675635014887 FtsH Extracellular; Region: FtsH_ext; pfam06480 675635014888 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 675635014889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635014890 Walker A motif; other site 675635014891 ATP binding site [chemical binding]; other site 675635014892 Walker B motif; other site 675635014893 arginine finger; other site 675635014894 Peptidase family M41; Region: Peptidase_M41; pfam01434 675635014895 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635014896 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635014897 active site 675635014898 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635014899 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 675635014900 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635014901 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 675635014902 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635014903 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 675635014904 dimer interface [polypeptide binding]; other site 675635014905 substrate binding site [chemical binding]; other site 675635014906 metal binding sites [ion binding]; metal-binding site 675635014907 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635014908 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635014909 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 675635014910 homotrimer interaction site [polypeptide binding]; other site 675635014911 putative active site [active] 675635014912 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 675635014913 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635014914 Walker B motif; other site 675635014915 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 675635014916 arginine finger; other site 675635014917 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635014918 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635014919 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 675635014920 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635014921 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635014922 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635014923 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 675635014924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635014925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635014926 Amino acid permease; Region: AA_permease_2; pfam13520 675635014927 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635014928 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635014929 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 675635014930 active site 675635014931 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635014932 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 675635014933 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635014934 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635014935 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635014936 Helix-turn-helix domains; Region: HTH; cl00088 675635014937 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 675635014938 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635014939 dimer interface [polypeptide binding]; other site 675635014940 active site 675635014941 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 675635014942 putative active site [active] 675635014943 putative catalytic site [active] 675635014944 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635014945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635014946 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 675635014947 Survival protein SurE; Region: SurE; cl00448 675635014948 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635014949 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635014950 active site 675635014951 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 675635014952 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635014953 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635014954 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 675635014955 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635014956 carboxyltransferase (CT) interaction site; other site 675635014957 biotinylation site [posttranslational modification]; other site 675635014958 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 675635014959 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 675635014960 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 675635014961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635014962 Helix-turn-helix domains; Region: HTH; cl00088 675635014963 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 675635014964 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635014965 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 675635014966 FAD binding pocket [chemical binding]; other site 675635014967 FAD binding motif [chemical binding]; other site 675635014968 phosphate binding motif [ion binding]; other site 675635014969 NAD binding pocket [chemical binding]; other site 675635014970 MbtH-like protein; Region: MbtH; cl01279 675635014971 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635014972 dimerization interface [polypeptide binding]; other site 675635014973 putative DNA binding site [nucleotide binding]; other site 675635014974 putative Zn2+ binding site [ion binding]; other site 675635014975 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 675635014976 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 675635014977 LamB/YcsF family; Region: LamB_YcsF; cl00664 675635014978 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 675635014979 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 675635014980 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 675635014981 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 675635014982 ThiC-associated domain; Region: ThiC-associated; pfam13667 675635014983 ThiC family; Region: ThiC; cl08031 675635014984 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635014985 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 675635014986 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635014987 DNA binding residues [nucleotide binding] 675635014988 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 675635014989 cyclase homology domain; Region: CHD; cd07302 675635014990 nucleotidyl binding site; other site 675635014991 metal binding site [ion binding]; metal-binding site 675635014992 dimer interface [polypeptide binding]; other site 675635014993 enoyl-CoA hydratase; Region: PLN02864 675635014994 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635014995 active site 2 [active] 675635014996 active site 1 [active] 675635014997 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 675635014998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635014999 NAD(P) binding site [chemical binding]; other site 675635015000 active site 675635015001 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 675635015002 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635015003 dimer interface [polypeptide binding]; other site 675635015004 active site 675635015005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635015006 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635015007 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635015008 active site 675635015009 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635015010 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635015011 putative NAD(P) binding site [chemical binding]; other site 675635015012 DinB superfamily; Region: DinB_2; pfam12867 675635015013 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635015014 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635015015 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635015016 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 675635015017 aminotransferase; Validated; Region: PRK07777 675635015018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635015019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635015020 homodimer interface [polypeptide binding]; other site 675635015021 catalytic residue [active] 675635015022 Winged helix-turn helix; Region: HTH_29; pfam13551 675635015023 Helix-turn-helix domains; Region: HTH; cl00088 675635015024 Integrase core domain; Region: rve; cl01316 675635015025 short chain dehydrogenase; Validated; Region: PRK05855 675635015026 classical (c) SDRs; Region: SDR_c; cd05233 675635015027 NAD(P) binding site [chemical binding]; other site 675635015028 active site 675635015029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635015030 putative substrate translocation pore; other site 675635015031 Helix-turn-helix domains; Region: HTH; cl00088 675635015032 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 675635015033 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 675635015034 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 675635015035 Helix-turn-helix domains; Region: HTH; cl00088 675635015036 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635015037 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635015038 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635015039 active site 675635015040 metal binding site [ion binding]; metal-binding site 675635015041 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 675635015042 Predicted membrane protein [Function unknown]; Region: COG2364 675635015043 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635015044 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 675635015045 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015046 Walker A/P-loop; other site 675635015047 ATP binding site [chemical binding]; other site 675635015048 Q-loop/lid; other site 675635015049 ABC transporter signature motif; other site 675635015050 Walker B; other site 675635015051 D-loop; other site 675635015052 H-loop/switch region; other site 675635015053 Bifunctional nuclease; Region: DNase-RNase; cl00553 675635015054 putative sialic acid transporter; Region: 2A0112; TIGR00891 675635015055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635015056 putative substrate translocation pore; other site 675635015057 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 675635015058 PspA/IM30 family; Region: PspA_IM30; pfam04012 675635015059 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 675635015060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 675635015061 pyrimidine utilization protein A; Region: RutA; TIGR03612 675635015062 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635015063 active site 675635015064 dimer interface [polypeptide binding]; other site 675635015065 non-prolyl cis peptide bond; other site 675635015066 insertion regions; other site 675635015067 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635015068 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635015069 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 675635015070 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635015071 Amidase; Region: Amidase; cl11426 675635015072 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635015073 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635015074 active site 675635015075 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635015076 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635015077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635015078 DNA-binding site [nucleotide binding]; DNA binding site 675635015079 NlpC/P60 family; Region: NLPC_P60; cl11438 675635015080 NlpC/P60 family; Region: NLPC_P60; cl11438 675635015081 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635015082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015083 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 675635015084 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 675635015085 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 675635015086 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635015087 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635015088 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635015089 catalytic loop [active] 675635015090 iron binding site [ion binding]; other site 675635015091 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635015092 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 675635015093 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635015094 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635015095 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635015096 substrate binding site [chemical binding]; other site 675635015097 oxyanion hole (OAH) forming residues; other site 675635015098 trimer interface [polypeptide binding]; other site 675635015099 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 675635015100 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 675635015101 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635015102 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635015103 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635015104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015105 NAD(P) binding site [chemical binding]; other site 675635015106 active site 675635015107 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635015108 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635015109 AMP-binding enzyme; Region: AMP-binding; cl15778 675635015110 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635015111 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635015112 Helix-turn-helix domains; Region: HTH; cl00088 675635015113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015114 NAD(P) binding site [chemical binding]; other site 675635015115 active site 675635015116 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 675635015117 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 675635015118 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635015119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635015120 active site 675635015121 phosphorylation site [posttranslational modification] 675635015122 intermolecular recognition site; other site 675635015123 dimerization interface [polypeptide binding]; other site 675635015124 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015125 DNA binding residues [nucleotide binding] 675635015126 dimerization interface [polypeptide binding]; other site 675635015127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635015128 Histidine kinase; Region: HisKA_3; pfam07730 675635015129 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 675635015130 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635015131 catalytic residue [active] 675635015132 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 675635015133 lipoyl attachment site [posttranslational modification]; other site 675635015134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635015135 non-specific DNA binding site [nucleotide binding]; other site 675635015136 salt bridge; other site 675635015137 sequence-specific DNA binding site [nucleotide binding]; other site 675635015138 Cupin domain; Region: Cupin_2; cl09118 675635015139 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 675635015140 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 675635015141 dimerization interface [polypeptide binding]; other site 675635015142 ATP binding site [chemical binding]; other site 675635015143 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 675635015144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015145 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 675635015146 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 675635015147 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635015148 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635015149 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 675635015150 hydrophobic ligand binding site; other site 675635015151 Phosphoglycerate kinase; Region: PGK; pfam00162 675635015152 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 675635015153 substrate binding site [chemical binding]; other site 675635015154 hinge regions; other site 675635015155 ADP binding site [chemical binding]; other site 675635015156 catalytic site [active] 675635015157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015158 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 675635015159 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 675635015160 haloacid dehalogenase-like hydrolase family protein; Region: PLN02779 675635015161 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635015162 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635015163 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 675635015164 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 675635015165 putative substrate binding site [chemical binding]; other site 675635015166 nucleotide binding site [chemical binding]; other site 675635015167 nucleotide binding site [chemical binding]; other site 675635015168 homodimer interface [polypeptide binding]; other site 675635015169 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635015170 catalytic residue [active] 675635015171 phosphoribulokinase; Provisional; Region: PRK07429 675635015172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015173 active site 675635015174 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 675635015175 TPP-binding site [chemical binding]; other site 675635015176 dimer interface [polypeptide binding]; other site 675635015177 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 675635015178 PYR/PP interface [polypeptide binding]; other site 675635015179 dimer interface [polypeptide binding]; other site 675635015180 TPP binding site [chemical binding]; other site 675635015181 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635015182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635015183 active site 675635015184 phosphorylation site [posttranslational modification] 675635015185 intermolecular recognition site; other site 675635015186 dimerization interface [polypeptide binding]; other site 675635015187 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015188 DNA binding residues [nucleotide binding] 675635015189 dimerization interface [polypeptide binding]; other site 675635015190 GAF domain; Region: GAF; cl15785 675635015191 GAF domain; Region: GAF_2; pfam13185 675635015192 Histidine kinase; Region: HisKA_3; pfam07730 675635015193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635015194 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635015195 Helix-turn-helix domains; Region: HTH; cl00088 675635015196 Integrase core domain; Region: rve; cl01316 675635015197 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635015198 catalytic residue [active] 675635015199 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 675635015200 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 675635015201 homodimer interface [polypeptide binding]; other site 675635015202 active site 675635015203 heterodimer interface [polypeptide binding]; other site 675635015204 catalytic residue [active] 675635015205 metal binding site [ion binding]; metal-binding site 675635015206 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 675635015207 multimerization interface [polypeptide binding]; other site 675635015208 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 675635015209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635015210 Walker A motif; other site 675635015211 ATP binding site [chemical binding]; other site 675635015212 Walker B motif; other site 675635015213 arginine finger; other site 675635015214 Helix-turn-helix domains; Region: HTH; cl00088 675635015215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635015216 dimerization interface [polypeptide binding]; other site 675635015217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015218 DNA binding residues [nucleotide binding] 675635015219 dimerization interface [polypeptide binding]; other site 675635015220 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 675635015221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015223 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 675635015224 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 675635015225 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635015226 active site residue [active] 675635015227 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635015228 active site residue [active] 675635015229 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635015230 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635015231 active site 675635015232 non-prolyl cis peptide bond; other site 675635015233 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635015234 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 675635015235 Walker A/P-loop; other site 675635015236 ATP binding site [chemical binding]; other site 675635015237 Q-loop/lid; other site 675635015238 ABC transporter signature motif; other site 675635015239 Walker B; other site 675635015240 D-loop; other site 675635015241 H-loop/switch region; other site 675635015242 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 675635015243 Walker A/P-loop; other site 675635015244 ATP binding site [chemical binding]; other site 675635015245 Q-loop/lid; other site 675635015246 ABC transporter signature motif; other site 675635015247 Walker B; other site 675635015248 D-loop; other site 675635015249 H-loop/switch region; other site 675635015250 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635015251 TM-ABC transporter signature motif; other site 675635015252 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635015253 TM-ABC transporter signature motif; other site 675635015254 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 675635015255 ligand binding site [chemical binding]; other site 675635015256 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635015257 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635015258 DNA-binding site [nucleotide binding]; DNA binding site 675635015259 FCD domain; Region: FCD; cl11656 675635015260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635015261 dimer interface [polypeptide binding]; other site 675635015262 conserved gate region; other site 675635015263 putative PBP binding loops; other site 675635015264 ABC-ATPase subunit interface; other site 675635015265 NMT1-like family; Region: NMT1_2; cl15260 675635015266 NMT1/THI5 like; Region: NMT1; pfam09084 675635015267 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 675635015268 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 675635015269 Walker A/P-loop; other site 675635015270 ATP binding site [chemical binding]; other site 675635015271 Q-loop/lid; other site 675635015272 ABC transporter signature motif; other site 675635015273 Walker B; other site 675635015274 D-loop; other site 675635015275 H-loop/switch region; other site 675635015276 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635015277 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635015278 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 675635015279 Helix-turn-helix domains; Region: HTH; cl00088 675635015280 AMP-binding enzyme; Region: AMP-binding; cl15778 675635015281 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 675635015282 Helix-turn-helix domains; Region: HTH; cl00088 675635015283 membrane protein FdrA; Validated; Region: PRK06091 675635015284 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 675635015285 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 675635015286 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635015287 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635015288 active site 675635015289 metal binding site [ion binding]; metal-binding site 675635015290 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 675635015291 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635015292 membrane protein FdrA; Validated; Region: PRK06091 675635015293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015294 CoA-ligase; Region: Ligase_CoA; cl02894 675635015295 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 675635015296 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 675635015297 putative substrate binding site [chemical binding]; other site 675635015298 nucleotide binding site [chemical binding]; other site 675635015299 nucleotide binding site [chemical binding]; other site 675635015300 homodimer interface [polypeptide binding]; other site 675635015301 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 675635015302 Helix-turn-helix domains; Region: HTH; cl00088 675635015303 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015304 Tetratricopeptide repeat; Region: TPR_12; pfam13424 675635015305 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635015306 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 675635015307 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 675635015308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635015309 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635015310 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 675635015311 Dienelactone hydrolase family; Region: DLH; pfam01738 675635015312 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635015313 Sulfatase; Region: Sulfatase; cl10460 675635015314 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 675635015315 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635015316 active site 675635015317 nucleotide binding site [chemical binding]; other site 675635015318 HIGH motif; other site 675635015319 KMSKS motif; other site 675635015320 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635015321 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635015322 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635015323 active site 675635015324 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635015325 LabA_like proteins; Region: LabA_like; cd06167 675635015326 putative metal binding site [ion binding]; other site 675635015327 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 675635015328 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 675635015329 Helix-turn-helix domains; Region: HTH; cl00088 675635015330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015331 NAD(P) binding site [chemical binding]; other site 675635015332 active site 675635015333 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 675635015334 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015335 DNA binding residues [nucleotide binding] 675635015336 dimerization interface [polypeptide binding]; other site 675635015337 Cupin domain; Region: Cupin_2; cl09118 675635015338 Dienelactone hydrolase family; Region: DLH; pfam01738 675635015339 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635015340 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 675635015341 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635015342 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635015343 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635015344 dimerization interface [polypeptide binding]; other site 675635015345 putative DNA binding site [nucleotide binding]; other site 675635015346 putative Zn2+ binding site [ion binding]; other site 675635015347 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 675635015348 putative hydrophobic ligand binding site [chemical binding]; other site 675635015349 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635015350 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 675635015351 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 675635015352 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 675635015353 OsmC-like protein; Region: OsmC; cl00767 675635015354 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635015355 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635015356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015357 DNA binding residues [nucleotide binding] 675635015358 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635015359 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 675635015360 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635015361 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 675635015362 iron-sulfur cluster [ion binding]; other site 675635015363 [2Fe-2S] cluster binding site [ion binding]; other site 675635015364 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635015365 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635015366 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 675635015367 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635015368 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 675635015369 Helix-turn-helix domains; Region: HTH; cl00088 675635015370 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 675635015371 Predicted ATPase [General function prediction only]; Region: COG3903 675635015372 short chain dehydrogenase; Provisional; Region: PRK07041 675635015373 classical (c) SDRs; Region: SDR_c; cd05233 675635015374 NAD(P) binding site [chemical binding]; other site 675635015375 active site 675635015376 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 675635015377 Helix-turn-helix domains; Region: HTH; cl00088 675635015378 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 675635015379 dimerization interface [polypeptide binding]; other site 675635015380 substrate binding pocket [chemical binding]; other site 675635015381 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 675635015382 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635015383 ligand binding site [chemical binding]; other site 675635015384 flexible hinge region; other site 675635015385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635015386 ATP binding site [chemical binding]; other site 675635015387 Mg2+ binding site [ion binding]; other site 675635015388 G-X-G motif; other site 675635015389 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635015390 ATP binding site [chemical binding]; other site 675635015391 putative Mg++ binding site [ion binding]; other site 675635015392 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635015393 nucleotide binding region [chemical binding]; other site 675635015394 ATP-binding site [chemical binding]; other site 675635015395 Helix-turn-helix domains; Region: HTH; cl00088 675635015396 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 675635015397 classical (c) SDRs; Region: SDR_c; cd05233 675635015398 NAD(P) binding site [chemical binding]; other site 675635015399 active site 675635015400 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635015401 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635015402 enoyl-CoA hydratase; Provisional; Region: PRK12478 675635015403 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635015404 substrate binding site [chemical binding]; other site 675635015405 oxyanion hole (OAH) forming residues; other site 675635015406 trimer interface [polypeptide binding]; other site 675635015407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635015408 Helix-turn-helix domains; Region: HTH; cl00088 675635015409 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 675635015410 gating phenylalanine in ion channel; other site 675635015411 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635015412 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635015413 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635015414 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 675635015415 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 675635015416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015417 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 675635015418 AMP-binding enzyme; Region: AMP-binding; cl15778 675635015419 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 675635015420 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 675635015421 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635015422 Zn binding site [ion binding]; other site 675635015423 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635015424 Helix-turn-helix domains; Region: HTH; cl00088 675635015425 Integrase core domain; Region: rve; cl01316 675635015426 Cupin domain; Region: Cupin_2; cl09118 675635015427 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 675635015428 A new structural DNA glycosylase; Region: AlkD_like; cd06561 675635015429 active site 675635015430 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 675635015431 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 675635015432 putative dimer interface [polypeptide binding]; other site 675635015433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 675635015434 active site 675635015435 phosphorylation site [posttranslational modification] 675635015436 intermolecular recognition site; other site 675635015437 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015438 DNA binding residues [nucleotide binding] 675635015439 Histidine kinase; Region: HisKA_3; pfam07730 675635015440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635015441 ATP binding site [chemical binding]; other site 675635015442 Mg2+ binding site [ion binding]; other site 675635015443 G-X-G motif; other site 675635015444 Transposase domain (DUF772); Region: DUF772; cl15789 675635015445 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635015446 Transposase domain (DUF772); Region: DUF772; cl15789 675635015447 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 675635015448 DDE superfamily endonuclease; Region: DDE_5; cl02413 675635015449 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635015450 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635015451 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015452 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 675635015453 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 675635015454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635015455 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635015456 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635015457 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 675635015458 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 675635015459 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 675635015460 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 675635015461 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 675635015462 nickel binding site [ion binding]; other site 675635015463 NifU-like domain; Region: NifU; cl00484 675635015464 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 675635015465 iron-sulfur cluster [ion binding]; other site 675635015466 [2Fe-2S] cluster binding site [ion binding]; other site 675635015467 Acylphosphatase; Region: Acylphosphatase; cl00551 675635015468 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 675635015469 HypF finger; Region: zf-HYPF; pfam07503 675635015470 HypF finger; Region: zf-HYPF; pfam07503 675635015471 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 675635015472 HupF/HypC family; Region: HupF_HypC; cl00394 675635015473 HupF/HypC family; Region: HupF_HypC; cl00394 675635015474 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 675635015475 active site 675635015476 dimer interface [polypeptide binding]; other site 675635015477 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 675635015478 dimerization interface [polypeptide binding]; other site 675635015479 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 675635015480 ATP binding site [chemical binding]; other site 675635015481 HupF/HypC family; Region: HupF_HypC; cl00394 675635015482 Hydrogenase formation hypA family; Region: HypD; cl12072 675635015483 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 675635015484 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 675635015485 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 675635015486 active site 675635015487 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 675635015488 Transposase domain (DUF772); Region: DUF772; cl15789 675635015489 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635015490 Transposase domain (DUF772); Region: DUF772; cl15789 675635015491 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 675635015492 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635015493 Transposase domain (DUF772); Region: DUF772; cl15789 675635015494 Peptidase family M23; Region: Peptidase_M23; pfam01551 675635015495 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635015496 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635015497 hypothetical protein; Provisional; Region: PRK14851 675635015498 Amidase; Region: Amidase; cl11426 675635015499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635015500 Helix-turn-helix domains; Region: HTH; cl00088 675635015501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635015502 Helix-turn-helix domains; Region: HTH; cl00088 675635015503 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015504 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 675635015505 Walker A/P-loop; other site 675635015506 ATP binding site [chemical binding]; other site 675635015507 Q-loop/lid; other site 675635015508 ABC transporter signature motif; other site 675635015509 Walker B; other site 675635015510 D-loop; other site 675635015511 H-loop/switch region; other site 675635015512 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 675635015513 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635015514 metal-binding site [ion binding] 675635015515 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635015516 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635015517 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635015518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015519 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 675635015520 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635015521 metal-binding site [ion binding] 675635015522 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 675635015523 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015524 DNA binding residues [nucleotide binding] 675635015525 dimerization interface [polypeptide binding]; other site 675635015526 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 675635015527 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 675635015528 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 675635015529 putative catalytic site [active] 675635015530 putative metal binding site [ion binding]; other site 675635015531 putative phosphate binding site [ion binding]; other site 675635015532 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 675635015533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635015534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635015535 active site 675635015536 phosphorylation site [posttranslational modification] 675635015537 intermolecular recognition site; other site 675635015538 dimerization interface [polypeptide binding]; other site 675635015539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635015540 DNA binding site [nucleotide binding] 675635015541 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 675635015542 dimerization interface [polypeptide binding]; other site 675635015543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635015544 dimer interface [polypeptide binding]; other site 675635015545 phosphorylation site [posttranslational modification] 675635015546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635015547 ATP binding site [chemical binding]; other site 675635015548 Mg2+ binding site [ion binding]; other site 675635015549 G-X-G motif; other site 675635015550 DoxX; Region: DoxX; cl00976 675635015551 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 675635015552 Cl- selectivity filter; other site 675635015553 Cl- binding residues [ion binding]; other site 675635015554 pore gating glutamate residue; other site 675635015555 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 675635015556 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 675635015557 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 675635015558 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 675635015559 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 675635015560 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 675635015561 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 675635015562 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 675635015563 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 675635015564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015565 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 675635015566 DNA-binding site [nucleotide binding]; DNA binding site 675635015567 RNA-binding motif; other site 675635015568 tyramine oxidase; Provisional; Region: tynA; PRK11504 675635015569 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 675635015570 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 675635015571 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 675635015572 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 675635015573 Spore germination protein; Region: Spore_permease; cl15802 675635015574 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635015575 Helix-turn-helix domains; Region: HTH; cl00088 675635015576 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 675635015577 GAF domain; Region: GAF; cl15785 675635015578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635015579 dimer interface [polypeptide binding]; other site 675635015580 phosphorylation site [posttranslational modification] 675635015581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635015582 ATP binding site [chemical binding]; other site 675635015583 Mg2+ binding site [ion binding]; other site 675635015584 G-X-G motif; other site 675635015585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635015586 Response regulator receiver domain; Region: Response_reg; pfam00072 675635015587 active site 675635015588 phosphorylation site [posttranslational modification] 675635015589 intermolecular recognition site; other site 675635015590 dimerization interface [polypeptide binding]; other site 675635015591 Response regulator receiver domain; Region: Response_reg; pfam00072 675635015592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635015593 active site 675635015594 phosphorylation site [posttranslational modification] 675635015595 intermolecular recognition site; other site 675635015596 dimerization interface [polypeptide binding]; other site 675635015597 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 675635015598 Response regulator receiver domain; Region: Response_reg; pfam00072 675635015599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635015600 active site 675635015601 phosphorylation site [posttranslational modification] 675635015602 intermolecular recognition site; other site 675635015603 dimerization interface [polypeptide binding]; other site 675635015604 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 675635015605 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 675635015606 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015607 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015608 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635015609 ligand binding site [chemical binding]; other site 675635015610 flexible hinge region; other site 675635015611 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 675635015612 nucleophile elbow; other site 675635015613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635015614 active site 675635015615 phosphorylation site [posttranslational modification] 675635015616 intermolecular recognition site; other site 675635015617 FAD binding domain; Region: FAD_binding_4; pfam01565 675635015618 Berberine and berberine like; Region: BBE; pfam08031 675635015619 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 675635015620 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015621 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 675635015622 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015623 DNA binding residues [nucleotide binding] 675635015624 dimerization interface [polypeptide binding]; other site 675635015625 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635015626 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 675635015627 substrate binding site [chemical binding]; other site 675635015628 THF binding site; other site 675635015629 zinc-binding site [ion binding]; other site 675635015630 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635015631 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635015632 substrate binding site [chemical binding]; other site 675635015633 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635015634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635015635 putative substrate translocation pore; other site 675635015636 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 675635015637 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 675635015638 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635015639 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635015640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635015641 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 675635015642 AMP-binding enzyme; Region: AMP-binding; cl15778 675635015643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015644 hypothetical protein; Provisional; Region: PRK06847 675635015645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015646 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 675635015647 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635015648 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635015649 active site 675635015650 metal binding site [ion binding]; metal-binding site 675635015651 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635015652 Helix-turn-helix domains; Region: HTH; cl00088 675635015653 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635015654 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635015655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635015656 DNA-binding site [nucleotide binding]; DNA binding site 675635015657 FCD domain; Region: FCD; cl11656 675635015658 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635015659 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 675635015660 NAD(P) binding site [chemical binding]; other site 675635015661 catalytic residues [active] 675635015662 benzoate transport; Region: 2A0115; TIGR00895 675635015663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635015664 putative substrate translocation pore; other site 675635015665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635015666 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635015667 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 675635015668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015669 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635015670 substrate binding site [chemical binding]; other site 675635015671 trimer interface [polypeptide binding]; other site 675635015672 oxyanion hole (OAH) forming residues; other site 675635015673 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635015674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015675 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635015676 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 675635015677 Helix-turn-helix domains; Region: HTH; cl00088 675635015678 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 675635015679 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635015680 Protein of unknown function (DUF917); Region: DUF917; pfam06032 675635015681 Uncharacterized conserved protein [Function unknown]; Region: COG3535 675635015682 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635015683 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 675635015684 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635015685 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635015686 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635015687 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635015688 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635015689 catalytic loop [active] 675635015690 iron binding site [ion binding]; other site 675635015691 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635015692 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635015693 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635015694 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635015695 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 675635015696 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635015697 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635015698 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635015699 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635015700 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635015701 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635015702 catalytic loop [active] 675635015703 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635015704 iron binding site [ion binding]; other site 675635015705 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635015706 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 675635015707 active site 675635015708 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635015709 active site 675635015710 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 675635015711 dimer interface [polypeptide binding]; other site 675635015712 non-prolyl cis peptide bond; other site 675635015713 insertion regions; other site 675635015714 Domain of unknown function (DUF336); Region: DUF336; cl01249 675635015715 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635015716 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 675635015717 classical (c) SDRs; Region: SDR_c; cd05233 675635015718 NAD(P) binding site [chemical binding]; other site 675635015719 active site 675635015720 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635015721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635015722 TIGR02679 family protein; Region: TIGR02679 675635015723 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 675635015724 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 675635015725 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 675635015726 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 675635015727 TIGR02677 family protein; Region: TIGR02677 675635015728 TIGR02680 family protein; Region: TIGR02680 675635015729 TIGR02680 family protein; Region: TIGR02680 675635015730 TIGR02680 family protein; Region: TIGR02680 675635015731 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 675635015732 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 675635015733 Divergent AAA domain; Region: AAA_4; pfam04326 675635015734 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 675635015735 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635015736 DNA polymerase III subunit delta'; Validated; Region: PRK07940 675635015737 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015738 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 675635015739 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 675635015740 Transglycosylase; Region: Transgly; cl07896 675635015741 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635015742 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635015743 Transcription factor WhiB; Region: Whib; pfam02467 675635015744 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 675635015745 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 675635015746 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 675635015747 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 675635015748 P loop; other site 675635015749 Nucleotide binding site [chemical binding]; other site 675635015750 DTAP/Switch II; other site 675635015751 Switch I; other site 675635015752 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 675635015753 DTAP/Switch II; other site 675635015754 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 675635015755 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015756 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 675635015757 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 675635015758 homotrimer interaction site [polypeptide binding]; other site 675635015759 putative active site [active] 675635015760 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635015761 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635015762 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 675635015763 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635015764 ligand binding site [chemical binding]; other site 675635015765 flexible hinge region; other site 675635015766 Helix-turn-helix domains; Region: HTH; cl00088 675635015767 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 675635015768 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 675635015769 minor groove reading motif; other site 675635015770 helix-hairpin-helix signature motif; other site 675635015771 substrate binding pocket [chemical binding]; other site 675635015772 active site 675635015773 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 675635015774 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 675635015775 catalytic residues [active] 675635015776 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 675635015777 putative active site [active] 675635015778 putative CoA binding site [chemical binding]; other site 675635015779 nudix motif; other site 675635015780 metal binding site [ion binding]; metal-binding site 675635015781 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635015782 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 675635015783 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 675635015784 GDP-binding site [chemical binding]; other site 675635015785 ACT binding site; other site 675635015786 IMP binding site; other site 675635015787 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 675635015788 alpha-gamma subunit interface [polypeptide binding]; other site 675635015789 beta-gamma subunit interface [polypeptide binding]; other site 675635015790 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 675635015791 alpha-beta subunit interface [polypeptide binding]; other site 675635015792 urease subunit alpha; Reviewed; Region: ureC; PRK13206 675635015793 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 675635015794 subunit interactions [polypeptide binding]; other site 675635015795 active site 675635015796 flap region; other site 675635015797 UreF; Region: UreF; pfam01730 675635015798 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015799 UreD urease accessory protein; Region: UreD; cl00530 675635015800 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 675635015801 putative acyl-acceptor binding pocket; other site 675635015802 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 675635015803 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 675635015804 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635015805 active site 675635015806 intersubunit interface [polypeptide binding]; other site 675635015807 zinc binding site [ion binding]; other site 675635015808 Na+ binding site [ion binding]; other site 675635015809 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 675635015810 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635015811 DNA binding residues [nucleotide binding] 675635015812 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 675635015813 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 675635015814 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 675635015815 hypothetical protein; Provisional; Region: PRK08204 675635015816 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635015817 active site 675635015818 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 675635015819 Helix-turn-helix domains; Region: HTH; cl00088 675635015820 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635015821 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635015822 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635015823 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 675635015824 active site 675635015825 citrylCoA binding site [chemical binding]; other site 675635015826 oxalacetate binding site [chemical binding]; other site 675635015827 coenzyme A binding site [chemical binding]; other site 675635015828 catalytic triad [active] 675635015829 Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359 675635015830 active site 675635015831 Fe(II) binding site [ion binding]; other site 675635015832 dimer interface [polypeptide binding]; other site 675635015833 tetramer interface [polypeptide binding]; other site 675635015834 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 675635015835 dimer interface [polypeptide binding]; other site 675635015836 tetramer interface [polypeptide binding]; other site 675635015837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015838 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635015839 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635015840 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 675635015841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635015842 Walker A motif; other site 675635015843 ATP binding site [chemical binding]; other site 675635015844 Walker B motif; other site 675635015845 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015846 ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Region: RPT1; COG1222 675635015847 Peptidase family M41; Region: Peptidase_M41; pfam01434 675635015848 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 675635015849 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635015850 active site 675635015851 classical (c) SDRs; Region: SDR_c; cd05233 675635015852 NAD(P) binding site [chemical binding]; other site 675635015853 active site 675635015854 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 675635015855 Clp amino terminal domain; Region: Clp_N; pfam02861 675635015856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635015857 Walker A motif; other site 675635015858 ATP binding site [chemical binding]; other site 675635015859 Walker B motif; other site 675635015860 arginine finger; other site 675635015861 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 675635015862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635015863 Walker A motif; other site 675635015864 ATP binding site [chemical binding]; other site 675635015865 Walker B motif; other site 675635015866 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 675635015867 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 675635015868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635015869 ATP binding site [chemical binding]; other site 675635015870 Walker B motif; other site 675635015871 arginine finger; other site 675635015872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 675635015873 TPR motif; other site 675635015874 Tetratricopeptide repeat; Region: TPR_16; pfam13432 675635015875 binding surface 675635015876 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635015877 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 675635015878 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 675635015879 heme-binding site [chemical binding]; other site 675635015880 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 675635015881 FAD binding pocket [chemical binding]; other site 675635015882 FAD binding motif [chemical binding]; other site 675635015883 phosphate binding motif [ion binding]; other site 675635015884 beta-alpha-beta structure motif; other site 675635015885 NAD binding pocket [chemical binding]; other site 675635015886 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635015887 DNA binding residues [nucleotide binding] 675635015888 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635015889 chaperone protein DnaJ; Provisional; Region: PRK14279 675635015890 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 675635015891 HSP70 interaction site [polypeptide binding]; other site 675635015892 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 675635015893 Zn binding sites [ion binding]; other site 675635015894 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 675635015895 dimer interface [polypeptide binding]; other site 675635015896 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 675635015897 dimer interface [polypeptide binding]; other site 675635015898 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 675635015899 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 675635015900 EspG family; Region: ESX-1_EspG; pfam14011 675635015901 NlpC/P60 family; Region: NLPC_P60; cl11438 675635015902 AAA-like domain; Region: AAA_10; pfam12846 675635015903 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 675635015904 4Fe-4S binding domain; Region: Fer4; cl02805 675635015905 Cysteine-rich domain; Region: CCG; pfam02754 675635015906 Cysteine-rich domain; Region: CCG; pfam02754 675635015907 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635015908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635015909 active site 675635015910 phosphorylation site [posttranslational modification] 675635015911 intermolecular recognition site; other site 675635015912 dimerization interface [polypeptide binding]; other site 675635015913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015914 DNA binding residues [nucleotide binding] 675635015915 dimerization interface [polypeptide binding]; other site 675635015916 Histidine kinase; Region: HisKA_3; pfam07730 675635015917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635015918 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 675635015919 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 675635015920 Walker A/P-loop; other site 675635015921 ATP binding site [chemical binding]; other site 675635015922 Q-loop/lid; other site 675635015923 ABC transporter signature motif; other site 675635015924 Walker B; other site 675635015925 D-loop; other site 675635015926 H-loop/switch region; other site 675635015927 2'-deoxycytidine 5'-triphosphate deaminase (DCD); Region: DCD; pfam06559 675635015928 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 675635015929 trimer interface [polypeptide binding]; other site 675635015930 active site 675635015931 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635015932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015933 FAD binding domain; Region: FAD_binding_3; pfam01494 675635015934 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015935 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 675635015936 active site 675635015937 NlpC/P60 family; Region: NLPC_P60; cl11438 675635015938 AAA-like domain; Region: AAA_10; pfam12846 675635015939 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 675635015940 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 675635015941 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635015942 P-loop; other site 675635015943 Magnesium ion binding site [ion binding]; other site 675635015944 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 675635015945 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 675635015946 Dynamin family; Region: Dynamin_N; pfam00350 675635015947 G1 box; other site 675635015948 GTP/Mg2+ binding site [chemical binding]; other site 675635015949 G2 box; other site 675635015950 Switch I region; other site 675635015951 G3 box; other site 675635015952 Switch II region; other site 675635015953 G4 box; other site 675635015954 G5 box; other site 675635015955 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015956 Dynamin family; Region: Dynamin_N; pfam00350 675635015957 G1 box; other site 675635015958 GTP/Mg2+ binding site [chemical binding]; other site 675635015959 G2 box; other site 675635015960 Switch I region; other site 675635015961 G3 box; other site 675635015962 Switch II region; other site 675635015963 G4 box; other site 675635015964 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635015965 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 675635015966 catalytic loop [active] 675635015967 iron binding site [ion binding]; other site 675635015968 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635015969 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 675635015970 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635015971 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635015972 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 675635015973 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015974 DNA binding residues [nucleotide binding] 675635015975 dimerization interface [polypeptide binding]; other site 675635015976 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 675635015977 amidase catalytic site [active] 675635015978 Zn binding residues [ion binding]; other site 675635015979 substrate binding site [chemical binding]; other site 675635015980 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 675635015981 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 675635015982 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 675635015983 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635015984 active site 675635015985 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 675635015986 FOG: CBS domain [General function prediction only]; Region: COG0517 675635015987 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 675635015988 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 675635015989 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 675635015990 VanW like protein; Region: VanW; pfam04294 675635015991 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 675635015992 oligomerisation interface [polypeptide binding]; other site 675635015993 mobile loop; other site 675635015994 roof hairpin; other site 675635015995 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635015996 AAA domain; Region: AAA_22; pfam13401 675635015997 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 675635015998 Protein of unknown function (DUF541); Region: SIMPL; cl01077 675635015999 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 675635016000 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635016001 E3 interaction surface; other site 675635016002 lipoyl attachment site [posttranslational modification]; other site 675635016003 e3 binding domain; Region: E3_binding; pfam02817 675635016004 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 675635016005 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 675635016006 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635016007 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 675635016008 alpha subunit interface [polypeptide binding]; other site 675635016009 TPP binding site [chemical binding]; other site 675635016010 heterodimer interface [polypeptide binding]; other site 675635016011 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635016012 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 675635016013 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635016014 TPP-binding site [chemical binding]; other site 675635016015 tetramer interface [polypeptide binding]; other site 675635016016 heterodimer interface [polypeptide binding]; other site 675635016017 phosphorylation loop region [posttranslational modification] 675635016018 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 675635016019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 675635016020 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 675635016021 substrate binding pocket [chemical binding]; other site 675635016022 membrane-bound complex binding site; other site 675635016023 hinge residues; other site 675635016024 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 675635016025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635016026 dimer interface [polypeptide binding]; other site 675635016027 conserved gate region; other site 675635016028 putative PBP binding loops; other site 675635016029 ABC-ATPase subunit interface; other site 675635016030 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 675635016031 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 675635016032 Walker A/P-loop; other site 675635016033 ATP binding site [chemical binding]; other site 675635016034 Q-loop/lid; other site 675635016035 ABC transporter signature motif; other site 675635016036 Walker B; other site 675635016037 D-loop; other site 675635016038 H-loop/switch region; other site 675635016039 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 675635016040 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635016041 Sodium:solute symporter family; Region: SSF; cl00456 675635016042 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 675635016043 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 675635016044 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 675635016045 active site 675635016046 substrate-binding site [chemical binding]; other site 675635016047 metal-binding site [ion binding] 675635016048 GTP binding site [chemical binding]; other site 675635016049 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635016050 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635016051 Helix-turn-helix domains; Region: HTH; cl00088 675635016052 WYL domain; Region: WYL; cl14852 675635016053 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 675635016054 Helix-turn-helix domains; Region: HTH; cl00088 675635016055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635016056 dimerization interface [polypeptide binding]; other site 675635016057 LysE type translocator; Region: LysE; cl00565 675635016058 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 675635016059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635016060 putative substrate translocation pore; other site 675635016061 hypothetical protein; Provisional; Region: PRK06184 675635016062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635016063 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635016064 Helix-turn-helix domains; Region: HTH; cl00088 675635016065 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 675635016066 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 675635016067 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 675635016068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 675635016069 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 675635016070 active site 675635016071 dimer interface [polypeptide binding]; other site 675635016072 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 675635016073 CoenzymeA binding site [chemical binding]; other site 675635016074 subunit interaction site [polypeptide binding]; other site 675635016075 PHB binding site; other site 675635016076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635016077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635016078 ATP binding site [chemical binding]; other site 675635016079 Mg2+ binding site [ion binding]; other site 675635016080 G-X-G motif; other site 675635016081 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635016082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 675635016083 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635016084 DNA binding residues [nucleotide binding] 675635016085 dimerization interface [polypeptide binding]; other site 675635016086 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 675635016087 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635016088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635016089 dimer interface [polypeptide binding]; other site 675635016090 conserved gate region; other site 675635016091 putative PBP binding loops; other site 675635016092 ABC-ATPase subunit interface; other site 675635016093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635016094 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 675635016095 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635016096 Walker A/P-loop; other site 675635016097 ATP binding site [chemical binding]; other site 675635016098 Q-loop/lid; other site 675635016099 ABC transporter signature motif; other site 675635016100 Walker B; other site 675635016101 D-loop; other site 675635016102 H-loop/switch region; other site 675635016103 TOBE domain; Region: TOBE_2; cl01440 675635016104 LabA_like proteins; Region: LabA_like; cd06167 675635016105 putative metal binding site [ion binding]; other site 675635016106 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 675635016107 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635016108 active site 675635016109 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 675635016110 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 675635016111 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 675635016112 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635016113 replicative DNA helicase; Provisional; Region: PRK05636 675635016114 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 675635016115 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 675635016116 Walker A motif; other site 675635016117 ATP binding site [chemical binding]; other site 675635016118 Walker B motif; other site 675635016119 DNA binding loops [nucleotide binding] 675635016120 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 675635016121 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 675635016122 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 675635016123 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 675635016124 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 675635016125 dimer interface [polypeptide binding]; other site 675635016126 ssDNA binding site [nucleotide binding]; other site 675635016127 tetramer (dimer of dimers) interface [polypeptide binding]; other site 675635016128 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 675635016129 endonuclease IV; Provisional; Region: PRK01060 675635016130 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 675635016131 AP (apurinic/apyrimidinic) site pocket; other site 675635016132 DNA interaction; other site 675635016133 Metal-binding active site; metal-binding site 675635016134 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 675635016135 putative active site [active] 675635016136 putative CoA binding site [chemical binding]; other site 675635016137 nudix motif; other site 675635016138 metal binding site [ion binding]; metal-binding site 675635016139 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 675635016140 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 675635016141 Transglycosylase; Region: Transgly; cl07896 675635016142 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 675635016143 Helix-turn-helix domains; Region: HTH; cl00088 675635016144 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 675635016145 NlpC/P60 family; Region: NLPC_P60; cl11438 675635016146 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 675635016147 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 675635016148 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 675635016149 HIGH motif; other site 675635016150 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 675635016151 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635016152 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635016153 active site 675635016154 KMSKS motif; other site 675635016155 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 675635016156 tRNA binding surface [nucleotide binding]; other site 675635016157 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 675635016158 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 675635016159 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 675635016160 active site 675635016161 NTP binding site [chemical binding]; other site 675635016162 metal binding triad [ion binding]; metal-binding site 675635016163 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 675635016164 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 675635016165 Zn2+ binding site [ion binding]; other site 675635016166 Mg2+ binding site [ion binding]; other site 675635016167 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 675635016168 active site 675635016169 Ap6A binding site [chemical binding]; other site 675635016170 nudix motif; other site 675635016171 metal binding site [ion binding]; metal-binding site 675635016172 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635016173 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635016174 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635016175 DNA binding residues [nucleotide binding] 675635016176 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 675635016177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635016178 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 675635016179 catalytic residues [active] 675635016180 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 675635016181 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 675635016182 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 675635016183 active site 675635016184 metal binding site [ion binding]; metal-binding site 675635016185 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 675635016186 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 675635016187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635016188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635016189 homodimer interface [polypeptide binding]; other site 675635016190 catalytic residue [active] 675635016191 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 675635016192 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 675635016193 ATP-grasp domain; Region: ATP-grasp_4; cl03087 675635016194 ParB-like partition proteins; Region: parB_part; TIGR00180 675635016195 ParB-like nuclease domain; Region: ParBc; cl02129 675635016196 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 675635016197 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635016198 P-loop; other site 675635016199 Magnesium ion binding site [ion binding]; other site 675635016200 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635016201 Magnesium ion binding site [ion binding]; other site 675635016202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 675635016203 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 675635016204 G-X-X-G motif; other site 675635016205 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 675635016206 RxxxH motif; other site 675635016207 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 675635016208 Haemolytic domain; Region: Haemolytic; cl00506 675635016209 Ribonuclease P; Region: Ribonuclease_P; cl00457 675635016210 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 675635016211 D5 N terminal like; Region: D5_N; cl07360 675635016212 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 675635016213 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635016214 P-loop; other site 675635016215 Magnesium ion binding site [ion binding]; other site 675635016216 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635016217 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 675635016218 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635016219 MatE; Region: MatE; cl10513 675635016220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635016221 ParB-like partition proteins; Region: parB_part; TIGR00180 675635016222 ParB-like nuclease domain; Region: ParBc; cl02129 675635016223 KorB domain; Region: KorB; pfam08535 675635016224 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 675635016225 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635016226 P-loop; other site 675635016227 Magnesium ion binding site [ion binding]; other site 675635016228 Helix-turn-helix domains; Region: HTH; cl00088 675635016229 Winged helix-turn helix; Region: HTH_29; pfam13551 675635016230 Helix-turn-helix domains; Region: HTH; cl00088 675635016231 Integrase core domain; Region: rve; cl01316 675635016232 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 675635016233 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 675635016234 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635016235 MULE transposase domain; Region: MULE; pfam10551 675635016236 Cation efflux family; Region: Cation_efflux; cl00316 675635016237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635016238 dimerization interface [polypeptide binding]; other site 675635016239 putative DNA binding site [nucleotide binding]; other site 675635016240 putative Zn2+ binding site [ion binding]; other site 675635016241 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 675635016242 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 675635016243 catalytic residues [active] 675635016244 catalytic nucleophile [active] 675635016245 Presynaptic Site I dimer interface [polypeptide binding]; other site 675635016246 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 675635016247 Synaptic Flat tetramer interface [polypeptide binding]; other site 675635016248 Synaptic Site I dimer interface [polypeptide binding]; other site 675635016249 DNA binding site [nucleotide binding] 675635016250 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 675635016251 DNA-binding interface [nucleotide binding]; DNA binding site 675635016252 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635016253 MULE transposase domain; Region: MULE; pfam10551 675635016254 mercuric reductase; Validated; Region: PRK06370 675635016255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635016256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635016257 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635016258 Vitamin K epoxide reductase family; Region: VKOR; cl01729 675635016259 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 675635016260 catalytic residues [active] 675635016261 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635016262 dimerization interface [polypeptide binding]; other site 675635016263 putative DNA binding site [nucleotide binding]; other site 675635016264 putative Zn2+ binding site [ion binding]; other site 675635016265 mercuric reductase; Region: MerA; TIGR02053 675635016266 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635016267 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635016268 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635016269 active site 675635016270 DNA binding site [nucleotide binding] 675635016271 Int/Topo IB signature motif; other site 675635016272 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635016273 Amidase; Region: Amidase; cl11426 675635016274 pyrimidine utilization protein A; Region: RutA; TIGR03612 675635016275 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635016276 active site 675635016277 dimer interface [polypeptide binding]; other site 675635016278 non-prolyl cis peptide bond; other site 675635016279 insertion regions; other site 675635016280 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635016281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635016282 DNA-binding site [nucleotide binding]; DNA binding site 675635016283 FCD domain; Region: FCD; cl11656 675635016284 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 675635016285 putative active site [active] 675635016286 putative catalytic site [active] 675635016287 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635016288 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635016289 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635016290 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635016291 active site 675635016292 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 675635016293 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635016294 Amidase; Region: Amidase; cl11426 675635016295 pyrimidine utilization protein D; Region: RutD; TIGR03611 675635016296 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 675635016297 Flavin Reductases; Region: FlaRed; cl00801 675635016298 Plasma-membrane choline transporter; Region: Choline_transpo; pfam04515 675635016299 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 675635016300 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635016301 Walker B motif; other site 675635016302 NlpC/P60 family; Region: NLPC_P60; cl11438 675635016303 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635016304 Right handed beta helix region; Region: Beta_helix; pfam13229 675635016305 AAA-like domain; Region: AAA_10; pfam12846 675635016306 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 675635016307 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 675635016308 Domain of unknown function (DUF955); Region: DUF955; cl01076 675635016309 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 675635016310 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635016311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635016312 active site 675635016313 phosphorylation site [posttranslational modification] 675635016314 intermolecular recognition site; other site 675635016315 dimerization interface [polypeptide binding]; other site 675635016316 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635016317 DNA binding residues [nucleotide binding] 675635016318 dimerization interface [polypeptide binding]; other site 675635016319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 675635016320 PAS domain S-box; Region: sensory_box; TIGR00229 675635016321 Histidine kinase; Region: HisKA_3; pfam07730 675635016322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635016323 ATP binding site [chemical binding]; other site 675635016324 Mg2+ binding site [ion binding]; other site 675635016325 G-X-G motif; other site 675635016326 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 675635016327 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 675635016328 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635016329 active site 675635016330 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 675635016331 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 675635016332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635016333 NAD(P) binding site [chemical binding]; other site 675635016334 active site 675635016335 enoyl-CoA hydratase; Provisional; Region: PRK06563 675635016336 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635016337 substrate binding site [chemical binding]; other site 675635016338 oxyanion hole (OAH) forming residues; other site 675635016339 trimer interface [polypeptide binding]; other site 675635016340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635016341 substrate binding site [chemical binding]; other site 675635016342 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 675635016343 oxyanion hole (OAH) forming residues; other site 675635016344 trimer interface [polypeptide binding]; other site 675635016345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635016346 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 675635016347 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 675635016348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635016349 D-galactonate transporter; Region: 2A0114; TIGR00893 675635016350 putative substrate translocation pore; other site 675635016351 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 675635016352 putative active site [active] 675635016353 putative catalytic site [active] 675635016354 AMP-binding domain protein; Validated; Region: PRK07529 675635016355 AMP-binding enzyme; Region: AMP-binding; cl15778 675635016356 AMP-binding enzyme; Region: AMP-binding; cl15778 675635016357 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 675635016358 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635016359 dimer interface [polypeptide binding]; other site 675635016360 active site 675635016361 Helix-turn-helix domains; Region: HTH; cl00088 675635016362 putative transposase OrfB; Reviewed; Region: PHA02517 675635016363 HTH-like domain; Region: HTH_21; pfam13276 675635016364 Integrase core domain; Region: rve; cl01316 675635016365 Integrase core domain; Region: rve_3; cl15866 675635016366 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 675635016367 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 675635016368 active site 675635016369 NAD binding site [chemical binding]; other site 675635016370 metal binding site [ion binding]; metal-binding site 675635016371 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635016372 FAD binding domain; Region: FAD_binding_4; pfam01565 675635016373 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635016374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635016375 DNA-binding site [nucleotide binding]; DNA binding site 675635016376 FCD domain; Region: FCD; cl11656 675635016377 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635016378 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635016379 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 675635016380 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 675635016381 trimer interface [polypeptide binding]; other site 675635016382 putative metal binding site [ion binding]; other site 675635016383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635016384 Walker A motif; other site 675635016385 ATP binding site [chemical binding]; other site 675635016386 Walker B motif; other site 675635016387 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635016388 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635016389 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635016390 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635016391 substrate binding site [chemical binding]; other site 675635016392 oxyanion hole (OAH) forming residues; other site 675635016393 trimer interface [polypeptide binding]; other site 675635016394 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635016395 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635016396 FAD binding domain; Region: FAD_binding_4; pfam01565 675635016397 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 675635016398 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635016399 active site 675635016400 DNA binding site [nucleotide binding] 675635016401 Int/Topo IB signature motif; other site 675635016402 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 675635016403 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 675635016404 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 675635016405 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635016406 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 675635016407 ParB-like nuclease domain; Region: ParBc; cl02129 675635016408 ParB-like partition proteins; Region: parB_part; TIGR00180 675635016409 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 675635016410 dimer interface [polypeptide binding]; other site 675635016411 ssDNA binding site [nucleotide binding]; other site 675635016412 tetramer (dimer of dimers) interface [polypeptide binding]; other site 675635016413 Transcription factor WhiB; Region: Whib; pfam02467 675635016414 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 675635016415 polymerase nucleotide-binding site; other site 675635016416 DNA-binding residues [nucleotide binding]; DNA binding site 675635016417 nucleotide binding site [chemical binding]; other site 675635016418 primase nucleotide-binding site [nucleotide binding]; other site 675635016419 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 675635016420 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 675635016421 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635016422 active site residue [active] 675635016423 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 675635016424 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 675635016425 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 675635016426 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 675635016427 Short C-terminal domain; Region: SHOCT; cl01373 675635016428 Domain of unknown function DUF302; Region: DUF302; cl01364 675635016429 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635016430 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635016431 active site residue [active] 675635016432 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635016433 active site residue [active] 675635016434 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 675635016435 putative homodimer interface [polypeptide binding]; other site 675635016436 putative homotetramer interface [polypeptide binding]; other site 675635016437 putative allosteric switch controlling residues; other site 675635016438 putative metal binding site [ion binding]; other site 675635016439 putative homodimer-homodimer interface [polypeptide binding]; other site 675635016440 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635016441 MULE transposase domain; Region: MULE; pfam10551 675635016442 Helix-turn-helix domains; Region: HTH; cl00088 675635016443 Winged helix-turn helix; Region: HTH_29; pfam13551 675635016444 Helix-turn-helix domains; Region: HTH; cl00088 675635016445 Integrase core domain; Region: rve; cl01316 675635016446 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 675635016447 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 675635016448 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 675635016449 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 675635016450 NADH dehydrogenase; Region: NADHdh; cl00469 675635016451 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 675635016452 Domain of unknown function (DUF305); Region: DUF305; cl15795 675635016453 High-affinity nickel-transport protein; Region: NicO; cl00964 675635016454 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 675635016455 putative homodimer interface [polypeptide binding]; other site 675635016456 putative homotetramer interface [polypeptide binding]; other site 675635016457 putative allosteric switch controlling residues; other site 675635016458 putative metal binding site [ion binding]; other site 675635016459 putative homodimer-homodimer interface [polypeptide binding]; other site 675635016460 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635016461 metal-binding site [ion binding] 675635016462 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 675635016463 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635016464 metal-binding site [ion binding] 675635016465 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635016466 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 675635016467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635016468 S-adenosylmethionine binding site [chemical binding]; other site 675635016469 S-adenosylmethionine synthetase; Validated; Region: PRK05250 675635016470 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 675635016471 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 675635016472 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 675635016473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635016474 Fic/DOC family; Region: Fic; cl00960 675635016475 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 675635016476 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635016477 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635016478 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635016479 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635016480 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635016481 active site 675635016482 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635016483 Right handed beta helix region; Region: Beta_helix; pfam13229 675635016484 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 675635016485 AMP-binding enzyme; Region: AMP-binding; cl15778 675635016486 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635016487 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 675635016488 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 675635016489 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635016490 Walker A/P-loop; other site 675635016491 ATP binding site [chemical binding]; other site 675635016492 Q-loop/lid; other site 675635016493 ABC transporter signature motif; other site 675635016494 Walker B; other site 675635016495 D-loop; other site 675635016496 H-loop/switch region; other site 675635016497 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635016498 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 675635016499 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 675635016500 Walker A/P-loop; other site 675635016501 ATP binding site [chemical binding]; other site 675635016502 Q-loop/lid; other site 675635016503 ABC transporter signature motif; other site 675635016504 Walker B; other site 675635016505 D-loop; other site 675635016506 H-loop/switch region; other site 675635016507 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635016508 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635016509 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635016510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635016511 putative PBP binding loops; other site 675635016512 dimer interface [polypeptide binding]; other site 675635016513 ABC-ATPase subunit interface; other site 675635016514 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635016515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635016516 dimer interface [polypeptide binding]; other site 675635016517 conserved gate region; other site 675635016518 putative PBP binding loops; other site 675635016519 ABC-ATPase subunit interface; other site 675635016520 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635016521 Transcriptional regulators [Transcription]; Region: PurR; COG1609 675635016522 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 675635016523 DNA binding site [nucleotide binding] 675635016524 domain linker motif; other site 675635016525 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 675635016526 dimerization interface [polypeptide binding]; other site 675635016527 ligand binding site [chemical binding]; other site 675635016528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635016529 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635016530 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 675635016531 catalytic residue [active] 675635016532 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 675635016533 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 675635016534 Glycerate kinase family; Region: Gly_kinase; cl00841 675635016535 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 675635016536 active site 675635016537 metal binding site [ion binding]; metal-binding site 675635016538 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 675635016539 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 675635016540 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 675635016541 iron-sulfur cluster [ion binding]; other site 675635016542 [2Fe-2S] cluster binding site [ion binding]; other site 675635016543 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635016544 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635016545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635016546 putative substrate translocation pore; other site 675635016547 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635016548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635016549 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 675635016550 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 675635016551 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 675635016552 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 675635016553 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 675635016554 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 675635016555 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 675635016556 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 675635016557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635016558 Restriction endonuclease; Region: Mrr_cat; cl00516 675635016559 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635016560 MULE transposase domain; Region: MULE; pfam10551 675635016561 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 675635016562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 675635016563 NlpC/P60 family; Region: NLPC_P60; cl11438 675635016564 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 675635016565 polymerase nucleotide-binding site; other site 675635016566 DNA-binding residues [nucleotide binding]; DNA binding site 675635016567 nucleotide binding site [chemical binding]; other site 675635016568 primase nucleotide-binding site [nucleotide binding]; other site 675635016569 Helix-turn-helix domains; Region: HTH; cl00088 675635016570 replicative DNA helicase; Region: DnaB; TIGR00665 675635016571 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 675635016572 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 675635016573 Walker A motif; other site 675635016574 ATP binding site [chemical binding]; other site 675635016575 Walker B motif; other site 675635016576 DNA binding loops [nucleotide binding] 675635016577 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635016578 MULE transposase domain; Region: MULE; pfam10551 675635016579 Zeta toxin; Region: Zeta_toxin; pfam06414 675635016580 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635016581 active site 675635016582 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635016583 active site 675635016584 DNA binding site [nucleotide binding] 675635016585 Int/Topo IB signature motif; other site 675635016586 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635016587 MULE transposase domain; Region: MULE; pfam10551 675635016588 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635016589 FAD binding domain; Region: FAD_binding_4; pfam01565 675635016590 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 675635016591 Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism; Region: HOT; cd08190 675635016592 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 675635016593 putative active site [active] 675635016594 metal binding site [ion binding]; metal-binding site 675635016595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635016596 DNA-binding site [nucleotide binding]; DNA binding site 675635016597 FCD domain; Region: FCD; cl11656 675635016598 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 675635016599 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 675635016600 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635016601 NAD(P) binding site [chemical binding]; other site 675635016602 catalytic residues [active] 675635016603 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 675635016604 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635016605 catalytic loop [active] 675635016606 iron binding site [ion binding]; other site 675635016607 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 675635016608 FAD binding pocket [chemical binding]; other site 675635016609 FAD binding motif [chemical binding]; other site 675635016610 phosphate binding motif [ion binding]; other site 675635016611 beta-alpha-beta structure motif; other site 675635016612 NAD binding pocket [chemical binding]; other site 675635016613 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 675635016614 dimerization interface [polypeptide binding]; other site 675635016615 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635016616 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 675635016617 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635016618 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 675635016619 NAD(P) binding site [chemical binding]; other site 675635016620 catalytic residues [active] 675635016621 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 675635016622 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 675635016623 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635016624 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 675635016625 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635016626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635016627 Integrase core domain; Region: rve; cl01316 675635016628 transposase/IS protein; Provisional; Region: PRK09183 675635016629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635016630 Walker A motif; other site 675635016631 ATP binding site [chemical binding]; other site 675635016632 Walker B motif; other site 675635016633 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635016634 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635016635 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635016636 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635016637 ParB-like partition proteins; Region: parB_part; TIGR00180 675635016638 ParB-like nuclease domain; Region: ParBc; cl02129 675635016639 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 675635016640 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 675635016641 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635016642 Magnesium ion binding site [ion binding]; other site 675635016643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635016644 non-specific DNA binding site [nucleotide binding]; other site 675635016645 salt bridge; other site 675635016646 sequence-specific DNA binding site [nucleotide binding]; other site 675635016647 Transcription factor WhiB; Region: Whib; pfam02467 675635016648 AAA-like domain; Region: AAA_10; pfam12846 675635016649 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635016650 dimerization interface [polypeptide binding]; other site 675635016651 putative DNA binding site [nucleotide binding]; other site 675635016652 putative Zn2+ binding site [ion binding]; other site 675635016653 Transcription factor WhiB; Region: Whib; pfam02467 675635016654 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686