-- dump date 20120504_155738 -- class Genbank::misc_feature -- table misc_feature_note -- id note 911045000001 Peptidase family M23; Region: Peptidase_M23; pfam01551 911045000002 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045000003 AAA domain; Region: AAA_18; pfam13238 911045000004 Protein of unknown function (DUF998); Region: DUF998; pfam06197 911045000005 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 911045000006 Clp amino terminal domain; Region: Clp_N; pfam02861 911045000007 Clp amino terminal domain; Region: Clp_N; pfam02861 911045000008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045000009 Walker A motif; other site 911045000010 ATP binding site [chemical binding]; other site 911045000011 Walker B motif; other site 911045000012 arginine finger; other site 911045000013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045000014 Walker A motif; other site 911045000015 ATP binding site [chemical binding]; other site 911045000016 Walker B motif; other site 911045000017 arginine finger; other site 911045000018 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 911045000019 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 911045000020 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 911045000021 MOSC domain; Region: MOSC; pfam03473 911045000022 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 911045000023 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 911045000024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045000025 S-adenosylmethionine binding site [chemical binding]; other site 911045000026 peptide chain release factor 1; Validated; Region: prfA; PRK00591 911045000027 RF-1 domain; Region: RF-1; cl02875 911045000028 RF-1 domain; Region: RF-1; cl02875 911045000029 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 911045000030 GAF domain; Region: GAF; cl15785 911045000031 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 911045000032 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 911045000033 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 911045000034 aspartate kinase; Reviewed; Region: PRK06635 911045000035 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 911045000036 putative nucleotide binding site [chemical binding]; other site 911045000037 putative catalytic residues [active] 911045000038 putative Mg ion binding site [ion binding]; other site 911045000039 putative aspartate binding site [chemical binding]; other site 911045000040 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 911045000041 putative allosteric regulatory site; other site 911045000042 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 911045000043 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 911045000044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045000045 S-adenosylmethionine binding site [chemical binding]; other site 911045000046 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045000047 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045000048 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 911045000049 Predicted amidohydrolase [General function prediction only]; Region: COG0388 911045000050 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 911045000051 putative active site [active] 911045000052 catalytic triad [active] 911045000053 dimer interface [polypeptide binding]; other site 911045000054 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 911045000055 GSH binding site [chemical binding]; other site 911045000056 catalytic residues [active] 911045000057 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 911045000058 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045000059 active site 911045000060 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 911045000061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000062 Flp/Fap pilin component; Region: Flp_Fap; cl01585 911045000063 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 911045000064 active site 911045000065 8-oxo-dGMP binding site [chemical binding]; other site 911045000066 nudix motif; other site 911045000067 metal binding site [ion binding]; metal-binding site 911045000068 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045000069 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 911045000070 heterotetramer interface [polypeptide binding]; other site 911045000071 active site pocket [active] 911045000072 cleavage site 911045000073 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 911045000074 PPIC-type PPIASE domain; Region: Rotamase; cl08278 911045000075 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 911045000076 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 911045000077 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 911045000078 SEC-C motif; Region: SEC-C; pfam02810 911045000079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000080 Helix-turn-helix domains; Region: HTH; cl00088 911045000081 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 911045000082 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 911045000083 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 911045000084 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045000085 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045000086 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 911045000087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 911045000088 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045000089 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045000090 dimer interface [polypeptide binding]; other site 911045000091 putative CheW interface [polypeptide binding]; other site 911045000092 EamA-like transporter family; Region: EamA; cl01037 911045000093 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045000094 EamA-like transporter family; Region: EamA; cl01037 911045000095 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 911045000096 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045000097 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045000098 active site 911045000099 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 911045000100 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 911045000101 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 911045000102 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 911045000103 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045000104 active site 911045000105 catalytic tetrad [active] 911045000106 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 911045000107 active site 911045000108 catalytic triad [active] 911045000109 oxyanion hole [active] 911045000110 switch loop; other site 911045000111 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 911045000112 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 911045000113 Walker A/P-loop; other site 911045000114 ATP binding site [chemical binding]; other site 911045000115 Q-loop/lid; other site 911045000116 ABC transporter signature motif; other site 911045000117 Walker B; other site 911045000118 D-loop; other site 911045000119 H-loop/switch region; other site 911045000120 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 911045000121 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 911045000122 FtsX-like permease family; Region: FtsX; cl15850 911045000123 FtsX-like permease family; Region: FtsX; cl15850 911045000124 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 911045000125 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 911045000126 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 911045000127 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045000128 GAF domain; Region: GAF_2; pfam13185 911045000129 GAF domain; Region: GAF; cl15785 911045000130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045000131 dimerization interface [polypeptide binding]; other site 911045000132 putative DNA binding site [nucleotide binding]; other site 911045000133 putative Zn2+ binding site [ion binding]; other site 911045000134 Predicted permeases [General function prediction only]; Region: COG0701 911045000135 Predicted permease; Region: DUF318; pfam03773 911045000136 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 911045000137 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045000138 ATP binding site [chemical binding]; other site 911045000139 putative Mg++ binding site [ion binding]; other site 911045000140 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045000141 nucleotide binding region [chemical binding]; other site 911045000142 ATP-binding site [chemical binding]; other site 911045000143 RQC domain; Region: RQC; cl09632 911045000144 HRDC domain; Region: HRDC; cl02578 911045000145 Electron transfer DM13; Region: DM13; cl02735 911045000146 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 911045000147 apolar tunnel; other site 911045000148 heme binding site [chemical binding]; other site 911045000149 dimerization interface [polypeptide binding]; other site 911045000150 CAAX protease self-immunity; Region: Abi; cl00558 911045000151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045000152 metabolite-proton symporter; Region: 2A0106; TIGR00883 911045000153 putative substrate translocation pore; other site 911045000154 cystathionine gamma-lyase; Validated; Region: PRK07582 911045000155 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045000156 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045000157 catalytic residue [active] 911045000158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045000159 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045000160 putative substrate translocation pore; other site 911045000161 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 911045000162 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 911045000163 dimer interface [polypeptide binding]; other site 911045000164 substrate binding site [chemical binding]; other site 911045000165 metal binding sites [ion binding]; metal-binding site 911045000166 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 911045000167 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 911045000168 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 911045000169 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045000170 DNA binding site [nucleotide binding] 911045000171 Int/Topo IB signature motif; other site 911045000172 active site 911045000173 shikimate kinase; Provisional; Region: PRK13946 911045000174 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 911045000175 ADP binding site [chemical binding]; other site 911045000176 magnesium binding site [ion binding]; other site 911045000177 putative shikimate binding site; other site 911045000178 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 911045000179 active site 911045000180 dimer interface [polypeptide binding]; other site 911045000181 metal binding site [ion binding]; metal-binding site 911045000182 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 911045000183 Domain of unknown function DUF21; Region: DUF21; pfam01595 911045000184 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 911045000185 Transporter associated domain; Region: CorC_HlyC; cl08393 911045000186 BolA-like protein; Region: BolA; cl00386 911045000187 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 911045000188 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 911045000189 HSP70 interaction site [polypeptide binding]; other site 911045000190 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 911045000191 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 911045000192 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045000193 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 911045000194 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 911045000195 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 911045000196 metal ion-dependent adhesion site (MIDAS); other site 911045000197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 911045000198 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 911045000199 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 911045000200 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 911045000201 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 911045000202 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 911045000203 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 911045000204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 911045000205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000206 Protein of unknown function (DUF429); Region: DUF429; cl12046 911045000207 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 911045000208 dimer interface [polypeptide binding]; other site 911045000209 pyridoxamine kinase; Validated; Region: PRK05756 911045000210 pyridoxal binding site [chemical binding]; other site 911045000211 ATP binding site [chemical binding]; other site 911045000212 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 911045000213 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 911045000214 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 911045000215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000216 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 911045000217 NAD(P) binding site [chemical binding]; other site 911045000218 active site 911045000219 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 911045000220 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 911045000221 active site 911045000222 nucleophile elbow; other site 911045000223 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 911045000224 MltA-interacting protein MipA; Region: MipA; cl01504 911045000225 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 911045000226 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 911045000227 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 911045000228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 911045000229 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 911045000230 YGGT family; Region: YGGT; cl00508 911045000231 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 911045000232 Trm112p-like protein; Region: Trm112p; cl01066 911045000233 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 911045000234 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 911045000235 catalytic residues [active] 911045000236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 911045000237 binding surface 911045000238 TPR motif; other site 911045000239 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 911045000240 Uncharacterized conserved protein [Function unknown]; Region: COG3760 911045000241 putative deacylase active site [active] 911045000242 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 911045000243 FAD binding domain; Region: FAD_binding_3; pfam01494 911045000244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 911045000246 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 911045000247 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 911045000248 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 911045000249 generic binding surface I; other site 911045000250 generic binding surface II; other site 911045000251 DNA Polymerase Y-family; Region: PolY_like; cd03468 911045000252 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 911045000253 DNA binding site [nucleotide binding] 911045000254 Cell division inhibitor SulA; Region: SulA; cl01880 911045000255 MatE; Region: MatE; cl10513 911045000256 MatE; Region: MatE; cl10513 911045000257 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 911045000258 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045000259 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 911045000260 AMP-binding enzyme; Region: AMP-binding; cl15778 911045000261 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045000262 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 911045000263 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 911045000264 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 911045000265 Walker A/P-loop; other site 911045000266 ATP binding site [chemical binding]; other site 911045000267 Q-loop/lid; other site 911045000268 ABC transporter signature motif; other site 911045000269 Walker B; other site 911045000270 D-loop; other site 911045000271 H-loop/switch region; other site 911045000272 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 911045000273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045000274 dimer interface [polypeptide binding]; other site 911045000275 conserved gate region; other site 911045000276 putative PBP binding loops; other site 911045000277 ABC-ATPase subunit interface; other site 911045000278 NMT1-like family; Region: NMT1_2; cl15260 911045000279 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 911045000280 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 911045000281 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 911045000282 putative NAD(P) binding site [chemical binding]; other site 911045000283 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 911045000284 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 911045000285 B12 binding site [chemical binding]; other site 911045000286 cobalt ligand [ion binding]; other site 911045000287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045000288 Helix-turn-helix domains; Region: HTH; cl00088 911045000289 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045000290 putative effector binding pocket; other site 911045000291 dimerization interface [polypeptide binding]; other site 911045000292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045000293 Bacterial SH3 domain; Region: SH3_3; cl02551 911045000294 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 911045000295 active site 911045000296 putative phosphate binding site [ion binding]; other site 911045000297 putative catalytic site [active] 911045000298 metal binding site A [ion binding]; metal-binding site 911045000299 DNA binding site [nucleotide binding] 911045000300 putative AP binding site [nucleotide binding]; other site 911045000301 putative metal binding site B [ion binding]; other site 911045000302 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 911045000303 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 911045000304 NAD(P) binding site [chemical binding]; other site 911045000305 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 911045000306 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 911045000307 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045000308 FeS/SAM binding site; other site 911045000309 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 911045000310 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 911045000311 TM2 domain; Region: TM2; cl00984 911045000312 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 911045000313 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 911045000314 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045000315 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045000316 Helix-turn-helix domains; Region: HTH; cl00088 911045000317 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 911045000318 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 911045000319 catalytic center binding site [active] 911045000320 ATP binding site [chemical binding]; other site 911045000321 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 911045000322 dihydropteroate synthase; Region: DHPS; TIGR01496 911045000323 substrate binding pocket [chemical binding]; other site 911045000324 dimer interface [polypeptide binding]; other site 911045000325 inhibitor binding site; inhibition site 911045000326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045000327 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045000328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045000329 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 911045000330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045000331 putative substrate translocation pore; other site 911045000332 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 911045000333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045000334 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045000335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045000336 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 911045000337 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 911045000338 G1 box; other site 911045000339 putative GEF interaction site [polypeptide binding]; other site 911045000340 GTP/Mg2+ binding site [chemical binding]; other site 911045000341 Switch I region; other site 911045000342 G2 box; other site 911045000343 G3 box; other site 911045000344 Switch II region; other site 911045000345 G4 box; other site 911045000346 G5 box; other site 911045000347 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 911045000348 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 911045000349 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 911045000350 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 911045000351 E-class dimer interface [polypeptide binding]; other site 911045000352 P-class dimer interface [polypeptide binding]; other site 911045000353 active site 911045000354 Cu2+ binding site [ion binding]; other site 911045000355 Zn2+ binding site [ion binding]; other site 911045000356 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 911045000357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000358 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 911045000359 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045000360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045000361 homodimer interface [polypeptide binding]; other site 911045000362 catalytic residue [active] 911045000363 hypothetical protein; Provisional; Region: PRK06034 911045000364 Chorismate mutase type II; Region: CM_2; cl00693 911045000365 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 911045000366 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045000367 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 911045000368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045000369 S-adenosylmethionine binding site [chemical binding]; other site 911045000370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000371 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 911045000372 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045000373 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 911045000374 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 911045000375 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 911045000376 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 911045000377 ANP binding site [chemical binding]; other site 911045000378 Substrate Binding Site II [chemical binding]; other site 911045000379 Substrate Binding Site I [chemical binding]; other site 911045000380 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 911045000381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045000382 S-adenosylmethionine binding site [chemical binding]; other site 911045000383 MAPEG family; Region: MAPEG; cl09190 911045000384 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 911045000385 Amino acid permease; Region: AA_permease_2; pfam13520 911045000386 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 911045000387 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 911045000388 homodimer interface [polypeptide binding]; other site 911045000389 substrate-cofactor binding pocket; other site 911045000390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045000391 catalytic residue [active] 911045000392 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 911045000393 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 911045000394 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 911045000395 trimer interface [polypeptide binding]; other site 911045000396 active site 911045000397 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 911045000398 trimer interface [polypeptide binding]; other site 911045000399 active site 911045000400 Uncharacterized conserved protein [Function unknown]; Region: COG1739 911045000401 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 911045000402 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 911045000403 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 911045000404 Domain of unknown function (DUF336); Region: DUF336; cl01249 911045000405 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 911045000406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045000407 motif II; other site 911045000408 Phospholipid methyltransferase; Region: PEMT; cl00763 911045000409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 911045000410 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 911045000411 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 911045000412 putative acyltransferase; Provisional; Region: PRK05790 911045000413 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 911045000414 dimer interface [polypeptide binding]; other site 911045000415 active site 911045000416 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 911045000417 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 911045000418 NAD(P) binding site [chemical binding]; other site 911045000419 homotetramer interface [polypeptide binding]; other site 911045000420 homodimer interface [polypeptide binding]; other site 911045000421 active site 911045000422 LysE type translocator; Region: LysE; cl00565 911045000423 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 911045000424 Transglycosylase; Region: Transgly; cl07896 911045000425 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 911045000426 Helix-turn-helix domains; Region: HTH; cl00088 911045000427 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 911045000428 dimerization interface [polypeptide binding]; other site 911045000429 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 911045000430 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 911045000431 dimer interface [polypeptide binding]; other site 911045000432 decamer (pentamer of dimers) interface [polypeptide binding]; other site 911045000433 catalytic triad [active] 911045000434 peroxidatic and resolving cysteines [active] 911045000435 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 911045000436 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 911045000437 TM2 domain; Region: TM2; cl00984 911045000438 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 911045000439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045000440 S-adenosylmethionine binding site [chemical binding]; other site 911045000441 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 911045000442 substrate binding pocket [chemical binding]; other site 911045000443 chain length determination region; other site 911045000444 substrate-Mg2+ binding site; other site 911045000445 catalytic residues [active] 911045000446 aspartate-rich region 1; other site 911045000447 active site lid residues [active] 911045000448 aspartate-rich region 2; other site 911045000449 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 911045000450 catalytic triad [active] 911045000451 conserved cis-peptide bond; other site 911045000452 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 911045000453 putative deacylase active site [active] 911045000454 Predicted esterase [General function prediction only]; Region: COG0400 911045000455 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045000456 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 911045000457 helix-hairpin-helix signature motif; other site 911045000458 substrate binding pocket [chemical binding]; other site 911045000459 active site 911045000460 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 911045000461 active site 911045000462 HIGH motif; other site 911045000463 nucleotide binding site [chemical binding]; other site 911045000464 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 911045000465 active site 911045000466 KMSKS motif; other site 911045000467 Membrane transport protein; Region: Mem_trans; cl09117 911045000468 Membrane transport protein; Region: Mem_trans; cl09117 911045000469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 911045000470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045000471 ATP binding site [chemical binding]; other site 911045000472 Mg2+ binding site [ion binding]; other site 911045000473 G-X-G motif; other site 911045000474 Response regulator receiver domain; Region: Response_reg; pfam00072 911045000475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045000476 active site 911045000477 phosphorylation site [posttranslational modification] 911045000478 intermolecular recognition site; other site 911045000479 dimerization interface [polypeptide binding]; other site 911045000480 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 911045000481 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 911045000482 putative catalytic residue [active] 911045000483 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 911045000484 active site 911045000485 Low molecular weight phosphatase family; Region: LMWPc; cd00115 911045000486 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 911045000487 aromatic arch; other site 911045000488 DCoH dimer interaction site [polypeptide binding]; other site 911045000489 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 911045000490 DCoH tetramer interaction site [polypeptide binding]; other site 911045000491 substrate binding site [chemical binding]; other site 911045000492 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 911045000493 CPxP motif; other site 911045000494 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 911045000495 Nitrogen regulatory protein P-II; Region: P-II; cl00412 911045000496 Nitrogen regulatory protein P-II; Region: P-II; smart00938 911045000497 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 911045000498 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045000499 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045000500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045000501 dimer interface [polypeptide binding]; other site 911045000502 conserved gate region; other site 911045000503 putative PBP binding loops; other site 911045000504 ABC-ATPase subunit interface; other site 911045000505 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 911045000506 Cation efflux family; Region: Cation_efflux; cl00316 911045000507 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 911045000508 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 911045000509 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 911045000510 catalytic residues [active] 911045000511 central insert; other site 911045000512 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 911045000513 CcmB protein; Region: CcmB; cl01016 911045000514 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 911045000515 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045000516 Walker A/P-loop; other site 911045000517 ATP binding site [chemical binding]; other site 911045000518 Q-loop/lid; other site 911045000519 ABC transporter signature motif; other site 911045000520 Walker B; other site 911045000521 D-loop; other site 911045000522 H-loop/switch region; other site 911045000523 Cupin domain; Region: Cupin_2; cl09118 911045000524 aconitate hydratase; Validated; Region: PRK09277 911045000525 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 911045000526 substrate binding site [chemical binding]; other site 911045000527 ligand binding site [chemical binding]; other site 911045000528 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 911045000529 substrate binding site [chemical binding]; other site 911045000530 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045000531 Helix-turn-helix domains; Region: HTH; cl00088 911045000532 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045000533 putative effector binding pocket; other site 911045000534 dimerization interface [polypeptide binding]; other site 911045000535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000536 NADH(P)-binding; Region: NAD_binding_10; pfam13460 911045000537 NAD(P) binding site [chemical binding]; other site 911045000538 active site 911045000539 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045000540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045000541 Coenzyme A binding pocket [chemical binding]; other site 911045000542 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 911045000543 active site clefts [active] 911045000544 zinc binding site [ion binding]; other site 911045000545 dimer interface [polypeptide binding]; other site 911045000546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045000547 Coenzyme A binding pocket [chemical binding]; other site 911045000548 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 911045000549 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 911045000550 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 911045000551 purine monophosphate binding site [chemical binding]; other site 911045000552 dimer interface [polypeptide binding]; other site 911045000553 putative catalytic residues [active] 911045000554 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 911045000555 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 911045000556 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 911045000557 16S rRNA methyltransferase B; Provisional; Region: PRK10901 911045000558 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 911045000559 putative RNA binding site [nucleotide binding]; other site 911045000560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045000561 S-adenosylmethionine binding site [chemical binding]; other site 911045000562 Peptidase family M48; Region: Peptidase_M48; cl12018 911045000563 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 911045000564 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 911045000565 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 911045000566 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 911045000567 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 911045000568 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045000569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045000570 homodimer interface [polypeptide binding]; other site 911045000571 catalytic residue [active] 911045000572 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 911045000573 DNA translocase FtsK; Provisional; Region: PRK10263 911045000574 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045000575 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 911045000576 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 911045000577 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045000578 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045000579 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 911045000580 GTP cyclohydrolase I; Provisional; Region: PLN03044 911045000581 active site 911045000582 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 911045000583 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 911045000584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045000585 Coenzyme A binding pocket [chemical binding]; other site 911045000586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 911045000587 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 911045000588 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 911045000589 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 911045000590 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 911045000591 putative acyl-acceptor binding pocket; other site 911045000592 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 911045000593 putative active site [active] 911045000594 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 911045000595 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 911045000596 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 911045000597 Walker A/P-loop; other site 911045000598 ATP binding site [chemical binding]; other site 911045000599 Q-loop/lid; other site 911045000600 ABC transporter signature motif; other site 911045000601 Walker B; other site 911045000602 D-loop; other site 911045000603 H-loop/switch region; other site 911045000604 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 911045000605 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 911045000606 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045000607 active site 911045000608 Response regulator receiver domain; Region: Response_reg; pfam00072 911045000609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045000610 active site 911045000611 phosphorylation site [posttranslational modification] 911045000612 intermolecular recognition site; other site 911045000613 dimerization interface [polypeptide binding]; other site 911045000614 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 911045000615 Active site serine [active] 911045000616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045000617 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 911045000618 diaminopimelate decarboxylase; Region: lysA; TIGR01048 911045000619 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 911045000620 active site 911045000621 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045000622 substrate binding site [chemical binding]; other site 911045000623 catalytic residues [active] 911045000624 dimer interface [polypeptide binding]; other site 911045000625 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 911045000626 argininosuccinate lyase; Provisional; Region: PRK00855 911045000627 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 911045000628 active sites [active] 911045000629 tetramer interface [polypeptide binding]; other site 911045000630 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 911045000631 catalytic residues [active] 911045000632 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045000633 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 911045000634 putative dimer interface [polypeptide binding]; other site 911045000635 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 911045000636 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 911045000637 active site 911045000638 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 911045000639 catalytic triad [active] 911045000640 dimer interface [polypeptide binding]; other site 911045000641 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 911045000642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000643 short chain dehydrogenase; Validated; Region: PRK06182 911045000644 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 911045000645 NADP binding site [chemical binding]; other site 911045000646 active site 911045000647 steroid binding site; other site 911045000648 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045000649 Sel1 repeat; Region: Sel1; cl02723 911045000650 Sel1 repeat; Region: Sel1; cl02723 911045000651 Sel1 repeat; Region: Sel1; cl02723 911045000652 Sel1 repeat; Region: Sel1; cl02723 911045000653 Sel1 repeat; Region: Sel1; cl02723 911045000654 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045000655 Sel1 repeat; Region: Sel1; cl02723 911045000656 Sel1 repeat; Region: Sel1; cl02723 911045000657 Sel1 repeat; Region: Sel1; cl02723 911045000658 Sel1 repeat; Region: Sel1; cl02723 911045000659 Sel1 repeat; Region: Sel1; cl02723 911045000660 Sel1 repeat; Region: Sel1; cl02723 911045000661 DEAD-like helicases superfamily; Region: DEXDc; smart00487 911045000662 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045000663 ATP binding site [chemical binding]; other site 911045000664 putative Mg++ binding site [ion binding]; other site 911045000665 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 911045000666 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045000667 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045000668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045000669 putative substrate translocation pore; other site 911045000670 TspO/MBR family; Region: TspO_MBR; cl01379 911045000671 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 911045000672 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 911045000673 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 911045000674 Ligand binding site [chemical binding]; other site 911045000675 Electron transfer flavoprotein domain; Region: ETF; pfam01012 911045000676 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 911045000677 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 911045000678 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 911045000679 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 911045000680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000681 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045000682 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 911045000683 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045000684 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 911045000685 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 911045000686 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045000687 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045000688 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 911045000689 putative C-terminal domain interface [polypeptide binding]; other site 911045000690 putative GSH binding site (G-site) [chemical binding]; other site 911045000691 putative dimer interface [polypeptide binding]; other site 911045000692 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 911045000693 dimer interface [polypeptide binding]; other site 911045000694 substrate binding pocket (H-site) [chemical binding]; other site 911045000695 N-terminal domain interface [polypeptide binding]; other site 911045000696 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 911045000697 acetyl-CoA synthetase; Provisional; Region: PRK00174 911045000698 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 911045000699 AMP-binding enzyme; Region: AMP-binding; cl15778 911045000700 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045000701 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 911045000702 TadE-like protein; Region: TadE; cl10688 911045000703 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 911045000704 active site 911045000705 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 911045000706 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 911045000707 substrate binding site [chemical binding]; other site 911045000708 ligand binding site [chemical binding]; other site 911045000709 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 911045000710 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045000711 putative active site [active] 911045000712 putative metal binding site [ion binding]; other site 911045000713 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 911045000714 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 911045000715 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 911045000716 RimM N-terminal domain; Region: RimM; pfam01782 911045000717 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 911045000718 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 911045000719 Chorismate mutase type II; Region: CM_2; cl00693 911045000720 signal recognition particle protein; Provisional; Region: PRK10867 911045000721 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 911045000722 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 911045000723 P loop; other site 911045000724 GTP binding site [chemical binding]; other site 911045000725 Signal peptide binding domain; Region: SRP_SPB; pfam02978 911045000726 Esterase/lipase [General function prediction only]; Region: COG1647 911045000727 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045000728 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 911045000729 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045000730 catalytic residue [active] 911045000731 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 911045000732 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 911045000733 HIGH motif; other site 911045000734 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 911045000735 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 911045000736 active site 911045000737 KMSKS motif; other site 911045000738 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 911045000739 tRNA binding surface [nucleotide binding]; other site 911045000740 Lipopolysaccharide-assembly; Region: LptE; cl01125 911045000741 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 911045000742 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 911045000743 ParB-like partition proteins; Region: parB_part; TIGR00180 911045000744 ParB-like nuclease domain; Region: ParBc; cl02129 911045000745 Helix-turn-helix domains; Region: HTH; cl00088 911045000746 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 911045000747 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045000748 P-loop; other site 911045000749 Magnesium ion binding site [ion binding]; other site 911045000750 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045000751 Magnesium ion binding site [ion binding]; other site 911045000752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 911045000753 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 911045000754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000756 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 911045000757 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 911045000758 trmE is a tRNA modification GTPase; Region: trmE; cd04164 911045000759 G1 box; other site 911045000760 GTP/Mg2+ binding site [chemical binding]; other site 911045000761 Switch I region; other site 911045000762 G2 box; other site 911045000763 Switch II region; other site 911045000764 G3 box; other site 911045000765 G4 box; other site 911045000766 G5 box; other site 911045000767 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 911045000768 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 911045000769 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 911045000770 catalytic residues [active] 911045000771 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 911045000772 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045000773 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045000774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045000775 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045000776 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045000777 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045000778 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045000779 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045000780 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045000781 transcription termination factor Rho; Provisional; Region: rho; PRK09376 911045000782 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 911045000783 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 911045000784 RNA binding site [nucleotide binding]; other site 911045000785 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 911045000786 multimer interface [polypeptide binding]; other site 911045000787 Walker A motif; other site 911045000788 ATP binding site [chemical binding]; other site 911045000789 Walker B motif; other site 911045000790 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 911045000791 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 911045000792 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 911045000793 substrate binding site [chemical binding]; other site 911045000794 active site 911045000795 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 911045000796 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 911045000797 active site 911045000798 dimer interface [polypeptide binding]; other site 911045000799 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 911045000800 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 911045000801 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 911045000802 shikimate binding site; other site 911045000803 NAD(P) binding site [chemical binding]; other site 911045000804 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 911045000805 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 911045000806 CoA-binding site [chemical binding]; other site 911045000807 ATP-binding [chemical binding]; other site 911045000808 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 911045000809 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 911045000810 active site 911045000811 substrate binding site [chemical binding]; other site 911045000812 catalytic site [active] 911045000813 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 911045000814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000815 Bacterial SH3 domain; Region: SH3_3; cl02551 911045000816 Bacterial SH3 domain; Region: SH3_3; cl02551 911045000817 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 911045000818 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 911045000819 NAD binding site [chemical binding]; other site 911045000820 homotetramer interface [polypeptide binding]; other site 911045000821 homodimer interface [polypeptide binding]; other site 911045000822 substrate binding site [chemical binding]; other site 911045000823 active site 911045000824 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 911045000825 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 911045000826 dimer interface [polypeptide binding]; other site 911045000827 active site 911045000828 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 911045000829 active site 1 [active] 911045000830 dimer interface [polypeptide binding]; other site 911045000831 active site 2 [active] 911045000832 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 911045000833 metal binding site 2 [ion binding]; metal-binding site 911045000834 putative DNA binding helix; other site 911045000835 metal binding site 1 [ion binding]; metal-binding site 911045000836 dimer interface [polypeptide binding]; other site 911045000837 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 911045000838 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 911045000839 minor groove reading motif; other site 911045000840 helix-hairpin-helix signature motif; other site 911045000841 substrate binding pocket [chemical binding]; other site 911045000842 active site 911045000843 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 911045000844 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 911045000845 Helix-turn-helix domain; Region: HTH_18; pfam12833 911045000846 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 911045000847 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 911045000848 DNA binding site [nucleotide binding] 911045000849 active site 911045000850 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 911045000851 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 911045000852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045000853 catalytic residue [active] 911045000854 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 911045000855 active site 911045000856 Bacterial SH3 domain; Region: SH3_3; cl02551 911045000857 chromosome segregation protein; Provisional; Region: PRK02224 911045000858 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 911045000859 Malic enzyme, N-terminal domain; Region: malic; pfam00390 911045000860 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 911045000861 putative NAD(P) binding site [chemical binding]; other site 911045000862 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 911045000863 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 911045000864 MutS domain I; Region: MutS_I; pfam01624 911045000865 MutS domain II; Region: MutS_II; pfam05188 911045000866 MutS family domain IV; Region: MutS_IV; pfam05190 911045000867 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 911045000868 Walker A/P-loop; other site 911045000869 ATP binding site [chemical binding]; other site 911045000870 Q-loop/lid; other site 911045000871 ABC transporter signature motif; other site 911045000872 Walker B; other site 911045000873 D-loop; other site 911045000874 H-loop/switch region; other site 911045000875 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 911045000876 putative active site [active] 911045000877 metal binding site [ion binding]; metal-binding site 911045000878 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 911045000879 trimer interface [polypeptide binding]; other site 911045000880 active site 911045000881 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 911045000882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045000883 motif II; other site 911045000884 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045000885 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 911045000886 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 911045000887 dimer interface [polypeptide binding]; other site 911045000888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045000889 catalytic residue [active] 911045000890 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 911045000891 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 911045000892 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 911045000893 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 911045000894 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 911045000895 substrate binding site [chemical binding]; other site 911045000896 active site 911045000897 catalytic residues [active] 911045000898 heterodimer interface [polypeptide binding]; other site 911045000899 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 911045000900 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 911045000901 active site 911045000902 HIGH motif; other site 911045000903 dimer interface [polypeptide binding]; other site 911045000904 KMSKS motif; other site 911045000905 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 911045000906 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 911045000907 PII uridylyl-transferase; Provisional; Region: PRK05092 911045000908 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 911045000909 metal binding triad; other site 911045000910 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 911045000911 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 911045000912 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 911045000913 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 911045000914 Smr domain; Region: Smr; cl02619 911045000915 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 911045000916 MltA specific insert domain; Region: MltA; cl08398 911045000917 3D domain; Region: 3D; cl01439 911045000918 Tim44-like domain; Region: Tim44; cl09208 911045000919 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 911045000920 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 911045000921 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045000922 OpgC protein; Region: OpgC_C; cl00792 911045000923 Acyltransferase family; Region: Acyl_transf_3; pfam01757 911045000924 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 911045000925 60S acidic ribosomal protein P0; Provisional; Region: PTZ00135 911045000926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000927 short chain dehydrogenase; Provisional; Region: PRK06179 911045000928 NAD(P) binding site [chemical binding]; other site 911045000929 active site 911045000930 WHG domain; Region: WHG; pfam13305 911045000931 DNA polymerase I; Provisional; Region: PRK05755 911045000932 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 911045000933 active site 911045000934 metal binding site 1 [ion binding]; metal-binding site 911045000935 putative 5' ssDNA interaction site; other site 911045000936 metal binding site 3; metal-binding site 911045000937 metal binding site 2 [ion binding]; metal-binding site 911045000938 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 911045000939 putative DNA binding site [nucleotide binding]; other site 911045000940 putative metal binding site [ion binding]; other site 911045000941 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 911045000942 active site 911045000943 catalytic site [active] 911045000944 substrate binding site [chemical binding]; other site 911045000945 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 911045000946 active site 911045000947 DNA binding site [nucleotide binding] 911045000948 catalytic site [active] 911045000949 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 911045000950 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 911045000951 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 911045000952 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045000953 Coenzyme A binding pocket [chemical binding]; other site 911045000954 Angiotensin-converting enzyme; Region: Peptidase_M2; pfam01401 911045000955 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 911045000956 active site 911045000957 Zn binding site [ion binding]; other site 911045000958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000959 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 911045000960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000961 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045000962 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 911045000963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045000964 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 911045000965 amphipathic channel; other site 911045000966 Asn-Pro-Ala signature motifs; other site 911045000967 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 911045000968 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045000969 N-terminal plug; other site 911045000970 ligand-binding site [chemical binding]; other site 911045000971 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 911045000972 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 911045000973 ATP binding site [chemical binding]; other site 911045000974 substrate interface [chemical binding]; other site 911045000975 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 911045000976 HrcA protein C terminal domain; Region: HrcA; pfam01628 911045000977 ribonuclease PH; Reviewed; Region: rph; PRK00173 911045000978 Ribonuclease PH; Region: RNase_PH_bact; cd11362 911045000979 hexamer interface [polypeptide binding]; other site 911045000980 active site 911045000981 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 911045000982 active site 911045000983 dimerization interface [polypeptide binding]; other site 911045000984 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 911045000985 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045000986 FeS/SAM binding site; other site 911045000987 HemN C-terminal domain; Region: HemN_C; pfam06969 911045000988 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 911045000989 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 911045000990 Uncharacterized conserved protein [Function unknown]; Region: COG3743 911045000991 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 911045000992 Protein of unknown function DUF45; Region: DUF45; cl00636 911045000993 Transglycosylase; Region: Transgly; cl07896 911045000994 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 911045000995 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045000996 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045000997 sensory histidine kinase AtoS; Provisional; Region: PRK11360 911045000998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045000999 dimer interface [polypeptide binding]; other site 911045001000 phosphorylation site [posttranslational modification] 911045001001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045001002 ATP binding site [chemical binding]; other site 911045001003 Mg2+ binding site [ion binding]; other site 911045001004 G-X-G motif; other site 911045001005 Response regulator receiver domain; Region: Response_reg; pfam00072 911045001006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045001007 active site 911045001008 phosphorylation site [posttranslational modification] 911045001009 intermolecular recognition site; other site 911045001010 dimerization interface [polypeptide binding]; other site 911045001011 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 911045001012 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 911045001013 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045001014 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 911045001015 glutathione synthetase; Provisional; Region: PRK05246 911045001016 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 911045001017 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045001018 Restriction endonuclease; Region: Mrr_cat; cl00516 911045001019 Predicted methyltransferases [General function prediction only]; Region: COG0313 911045001020 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 911045001021 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 911045001022 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 911045001023 putative ligand binding site [chemical binding]; other site 911045001024 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 911045001025 metal binding site [ion binding]; metal-binding site 911045001026 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 911045001027 Flavoprotein; Region: Flavoprotein; cl08021 911045001028 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 911045001029 choline dehydrogenase; Validated; Region: PRK02106 911045001030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045001031 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 911045001032 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 911045001033 helicase 45; Provisional; Region: PTZ00424 911045001034 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 911045001035 ATP binding site [chemical binding]; other site 911045001036 Mg++ binding site [ion binding]; other site 911045001037 motif III; other site 911045001038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045001039 nucleotide binding region [chemical binding]; other site 911045001040 ATP-binding site [chemical binding]; other site 911045001041 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045001042 putative DNA binding site [nucleotide binding]; other site 911045001043 putative Zn2+ binding site [ion binding]; other site 911045001044 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 911045001045 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 911045001046 active site 911045001047 LssY C-terminus; Region: LssY_C; pfam14067 911045001048 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 911045001049 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 911045001050 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 911045001051 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 911045001052 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045001053 active site 911045001054 catalytic tetrad [active] 911045001055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045001056 Helix-turn-helix domains; Region: HTH; cl00088 911045001057 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045001058 dimerization interface [polypeptide binding]; other site 911045001059 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045001060 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 911045001061 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045001062 FAD binding site [chemical binding]; other site 911045001063 substrate binding pocket [chemical binding]; other site 911045001064 catalytic base [active] 911045001065 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 911045001066 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045001067 tetrameric interface [polypeptide binding]; other site 911045001068 NAD binding site [chemical binding]; other site 911045001069 catalytic residues [active] 911045001070 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045001071 Helix-turn-helix domains; Region: HTH; cl00088 911045001072 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 911045001073 dimerization interface [polypeptide binding]; other site 911045001074 substrate binding pocket [chemical binding]; other site 911045001075 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045001076 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045001077 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 911045001078 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 911045001079 enoyl-CoA hydratase; Provisional; Region: PRK05862 911045001080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045001081 substrate binding site [chemical binding]; other site 911045001082 oxyanion hole (OAH) forming residues; other site 911045001083 trimer interface [polypeptide binding]; other site 911045001084 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 911045001085 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 911045001086 active site residue [active] 911045001087 DnaA N-terminal domain; Region: DnaA_N; pfam11638 911045001088 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 911045001089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045001090 Walker A motif; other site 911045001091 ATP binding site [chemical binding]; other site 911045001092 Walker B motif; other site 911045001093 arginine finger; other site 911045001094 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 911045001095 DnaA box-binding interface [nucleotide binding]; other site 911045001096 DNA polymerase III subunit beta; Validated; Region: PRK05643 911045001097 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 911045001098 putative DNA binding surface [nucleotide binding]; other site 911045001099 dimer interface [polypeptide binding]; other site 911045001100 beta-clamp/clamp loader binding surface; other site 911045001101 beta-clamp/translesion DNA polymerase binding surface; other site 911045001102 recombination protein F; Reviewed; Region: recF; PRK00064 911045001103 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 911045001104 Walker A/P-loop; other site 911045001105 ATP binding site [chemical binding]; other site 911045001106 Q-loop/lid; other site 911045001107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045001108 ABC transporter signature motif; other site 911045001109 Walker B; other site 911045001110 D-loop; other site 911045001111 H-loop/switch region; other site 911045001112 LysE type translocator; Region: LysE; cl00565 911045001113 LysE type translocator; Region: LysE; cl00565 911045001114 LysE type translocator; Region: LysE; cl00565 911045001115 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 911045001116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045001117 Mg2+ binding site [ion binding]; other site 911045001118 G-X-G motif; other site 911045001119 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 911045001120 anchoring element; other site 911045001121 dimer interface [polypeptide binding]; other site 911045001122 ATP binding site [chemical binding]; other site 911045001123 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 911045001124 active site 911045001125 putative metal-binding site [ion binding]; other site 911045001126 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 911045001127 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045001128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045001129 DNA-binding site [nucleotide binding]; DNA binding site 911045001130 FCD domain; Region: FCD; cl11656 911045001131 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 911045001132 CoenzymeA binding site [chemical binding]; other site 911045001133 subunit interaction site [polypeptide binding]; other site 911045001134 PHB binding site; other site 911045001135 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045001136 Helix-turn-helix domains; Region: HTH; cl00088 911045001137 Helix-turn-helix domains; Region: HTH; cl00088 911045001138 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 911045001139 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 911045001140 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 911045001141 putative hemin binding site; other site 911045001142 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045001143 ABC-ATPase subunit interface; other site 911045001144 dimer interface [polypeptide binding]; other site 911045001145 putative PBP binding regions; other site 911045001146 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 911045001147 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 911045001148 Walker A/P-loop; other site 911045001149 ATP binding site [chemical binding]; other site 911045001150 Q-loop/lid; other site 911045001151 ABC transporter signature motif; other site 911045001152 Walker B; other site 911045001153 D-loop; other site 911045001154 H-loop/switch region; other site 911045001155 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 911045001156 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045001157 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 911045001158 Walker A/P-loop; other site 911045001159 ATP binding site [chemical binding]; other site 911045001160 Q-loop/lid; other site 911045001161 ABC transporter signature motif; other site 911045001162 Walker B; other site 911045001163 D-loop; other site 911045001164 H-loop/switch region; other site 911045001165 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045001166 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045001167 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045001168 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 911045001169 NAD(P) binding site [chemical binding]; other site 911045001170 catalytic residues [active] 911045001171 choline dehydrogenase; Validated; Region: PRK02106 911045001172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045001173 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 911045001174 transcriptional regulator BetI; Validated; Region: PRK00767 911045001175 Helix-turn-helix domains; Region: HTH; cl00088 911045001176 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 911045001177 NMT1-like family; Region: NMT1_2; cl15260 911045001178 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 911045001179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001180 dimer interface [polypeptide binding]; other site 911045001181 conserved gate region; other site 911045001182 putative PBP binding loops; other site 911045001183 ABC-ATPase subunit interface; other site 911045001184 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 911045001185 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045001186 Walker A/P-loop; other site 911045001187 ATP binding site [chemical binding]; other site 911045001188 Q-loop/lid; other site 911045001189 ABC transporter signature motif; other site 911045001190 Walker B; other site 911045001191 D-loop; other site 911045001192 H-loop/switch region; other site 911045001193 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 911045001194 Peptidase family M48; Region: Peptidase_M48; cl12018 911045001195 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 911045001196 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 911045001197 putative active site [active] 911045001198 Zn binding site [ion binding]; other site 911045001199 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 911045001200 Helix-turn-helix domains; Region: HTH; cl00088 911045001201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045001202 dimerization interface [polypeptide binding]; other site 911045001203 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 911045001204 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 911045001205 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045001206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001207 dimer interface [polypeptide binding]; other site 911045001208 conserved gate region; other site 911045001209 putative PBP binding loops; other site 911045001210 ABC-ATPase subunit interface; other site 911045001211 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 911045001212 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045001213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001214 dimer interface [polypeptide binding]; other site 911045001215 conserved gate region; other site 911045001216 putative PBP binding loops; other site 911045001217 ABC-ATPase subunit interface; other site 911045001218 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 911045001219 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045001220 Walker A/P-loop; other site 911045001221 ATP binding site [chemical binding]; other site 911045001222 Q-loop/lid; other site 911045001223 ABC transporter signature motif; other site 911045001224 Walker B; other site 911045001225 D-loop; other site 911045001226 H-loop/switch region; other site 911045001227 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045001228 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 911045001229 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045001230 Walker A/P-loop; other site 911045001231 ATP binding site [chemical binding]; other site 911045001232 Q-loop/lid; other site 911045001233 ABC transporter signature motif; other site 911045001234 Walker B; other site 911045001235 D-loop; other site 911045001236 H-loop/switch region; other site 911045001237 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045001238 N-formylglutamate amidohydrolase; Region: FGase; cl01522 911045001239 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 911045001240 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 911045001241 ligand binding site [chemical binding]; other site 911045001242 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 911045001243 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 911045001244 Walker A/P-loop; other site 911045001245 ATP binding site [chemical binding]; other site 911045001246 Q-loop/lid; other site 911045001247 ABC transporter signature motif; other site 911045001248 Walker B; other site 911045001249 D-loop; other site 911045001250 H-loop/switch region; other site 911045001251 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 911045001252 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 911045001253 TM-ABC transporter signature motif; other site 911045001254 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 911045001255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 911045001256 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 911045001257 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 911045001258 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045001259 active site 911045001260 catalytic tetrad [active] 911045001261 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 911045001262 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 911045001263 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 911045001264 putative active site; other site 911045001265 catalytic residue [active] 911045001266 L-xylulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 911045001267 putative active site [active] 911045001268 putative N- and C-terminal domain interface [polypeptide binding]; other site 911045001269 putative xylulose binding site [chemical binding]; other site 911045001270 putative MgATP binding site [chemical binding]; other site 911045001271 metal binding site [ion binding]; metal-binding site 911045001272 choline dehydrogenase; Validated; Region: PRK02106 911045001273 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 911045001274 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 911045001275 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 911045001276 substrate binding site [chemical binding]; other site 911045001277 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 911045001278 substrate binding site [chemical binding]; other site 911045001279 ligand binding site [chemical binding]; other site 911045001280 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045001281 DNA binding site [nucleotide binding] 911045001282 Int/Topo IB signature motif; other site 911045001283 active site 911045001284 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 911045001285 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045001286 Walker A motif; other site 911045001287 ATP binding site [chemical binding]; other site 911045001288 Walker B motif; other site 911045001289 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 911045001290 DNA binding site [nucleotide binding] 911045001291 Int/Topo IB signature motif; other site 911045001292 active site 911045001293 catalytic residues [active] 911045001294 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 911045001295 DNA helicase, putative; Region: TIGR00376 911045001296 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045001297 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045001298 Family description; Region: UvrD_C_2; cl15862 911045001299 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 911045001300 putative active site [active] 911045001301 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 911045001302 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 911045001303 metal binding triad [ion binding]; metal-binding site 911045001304 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 911045001305 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 911045001306 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 911045001307 Imelysin; Region: Peptidase_M75; cl09159 911045001308 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 911045001309 Imelysin; Region: Peptidase_M75; cl09159 911045001310 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 911045001311 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 911045001312 putative active site [active] 911045001313 catalytic site [active] 911045001314 putative metal binding site [ion binding]; other site 911045001315 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045001316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001317 dimer interface [polypeptide binding]; other site 911045001318 conserved gate region; other site 911045001319 putative PBP binding loops; other site 911045001320 ABC-ATPase subunit interface; other site 911045001321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001322 dimer interface [polypeptide binding]; other site 911045001323 conserved gate region; other site 911045001324 putative PBP binding loops; other site 911045001325 ABC-ATPase subunit interface; other site 911045001326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045001327 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045001328 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045001329 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045001330 Walker A/P-loop; other site 911045001331 ATP binding site [chemical binding]; other site 911045001332 Q-loop/lid; other site 911045001333 ABC transporter signature motif; other site 911045001334 Walker B; other site 911045001335 D-loop; other site 911045001336 H-loop/switch region; other site 911045001337 TOBE domain; Region: TOBE_2; cl01440 911045001338 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 911045001339 Helix-turn-helix domains; Region: HTH; cl00088 911045001340 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045001341 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045001342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045001343 DNA-binding site [nucleotide binding]; DNA binding site 911045001344 FCD domain; Region: FCD; cl11656 911045001345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045001346 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 911045001347 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 911045001348 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 911045001349 NAD binding site [chemical binding]; other site 911045001350 dimer interface [polypeptide binding]; other site 911045001351 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 911045001352 substrate binding site [chemical binding]; other site 911045001353 tetramer (dimer of dimers) interface [polypeptide binding]; other site 911045001354 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 911045001355 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 911045001356 DNA binding site [nucleotide binding] 911045001357 catalytic residue [active] 911045001358 H2TH interface [polypeptide binding]; other site 911045001359 putative catalytic residues [active] 911045001360 turnover-facilitating residue; other site 911045001361 intercalation triad [nucleotide binding]; other site 911045001362 8OG recognition residue [nucleotide binding]; other site 911045001363 putative reading head residues; other site 911045001364 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 911045001365 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 911045001366 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 911045001367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045001368 S-adenosylmethionine binding site [chemical binding]; other site 911045001369 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 911045001370 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045001371 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045001372 ATP binding site [chemical binding]; other site 911045001373 Helix-turn-helix domains; Region: HTH; cl00088 911045001374 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 911045001375 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 911045001376 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 911045001377 active site 911045001378 FMN binding site [chemical binding]; other site 911045001379 substrate binding site [chemical binding]; other site 911045001380 3Fe-4S cluster binding site [ion binding]; other site 911045001381 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 911045001382 chaperone protein DnaJ; Provisional; Region: PRK10767 911045001383 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 911045001384 HSP70 interaction site [polypeptide binding]; other site 911045001385 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 911045001386 substrate binding site [polypeptide binding]; other site 911045001387 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 911045001388 Zn binding sites [ion binding]; other site 911045001389 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 911045001390 dimer interface [polypeptide binding]; other site 911045001391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045001392 S-adenosylmethionine binding site [chemical binding]; other site 911045001393 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045001394 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 911045001395 active site 911045001396 HslU subunit interaction site [polypeptide binding]; other site 911045001397 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 911045001398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045001399 Walker A motif; other site 911045001400 ATP binding site [chemical binding]; other site 911045001401 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045001402 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 911045001403 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 911045001404 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 911045001405 NifU-like domain; Region: NifU; cl00484 911045001406 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 911045001407 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 911045001408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045001409 Coenzyme A binding pocket [chemical binding]; other site 911045001410 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 911045001411 metal binding site 2 [ion binding]; metal-binding site 911045001412 putative DNA binding helix; other site 911045001413 metal binding site 1 [ion binding]; metal-binding site 911045001414 dimer interface [polypeptide binding]; other site 911045001415 structural Zn2+ binding site [ion binding]; other site 911045001416 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 911045001417 putative acyl-acceptor binding pocket; other site 911045001418 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 911045001419 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 911045001420 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045001421 FeS/SAM binding site; other site 911045001422 TRAM domain; Region: TRAM; cl01282 911045001423 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 911045001424 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045001425 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 911045001426 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 911045001427 Transporter associated domain; Region: CorC_HlyC; cl08393 911045001428 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 911045001429 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 911045001430 putative active site [active] 911045001431 catalytic triad [active] 911045001432 putative dimer interface [polypeptide binding]; other site 911045001433 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 911045001434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045001435 non-specific DNA binding site [nucleotide binding]; other site 911045001436 salt bridge; other site 911045001437 sequence-specific DNA binding site [nucleotide binding]; other site 911045001438 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 911045001439 S-adenosylmethionine synthetase; Validated; Region: PRK05250 911045001440 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 911045001441 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 911045001442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 911045001443 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 911045001444 ribosome maturation protein RimP; Reviewed; Region: PRK00092 911045001445 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 911045001446 Sm1 motif; other site 911045001447 D3 - B interaction site; other site 911045001448 D1 - D2 interaction site; other site 911045001449 Hfq - Hfq interaction site; other site 911045001450 RNA binding pocket [nucleotide binding]; other site 911045001451 Sm2 motif; other site 911045001452 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 911045001453 NusA N-terminal domain; Region: NusA_N; pfam08529 911045001454 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 911045001455 RNA binding site [nucleotide binding]; other site 911045001456 homodimer interface [polypeptide binding]; other site 911045001457 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 911045001458 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 911045001459 G-X-X-G motif; other site 911045001460 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 911045001461 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 911045001462 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 911045001463 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 911045001464 translation initiation factor IF-2; Region: IF-2; TIGR00487 911045001465 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 911045001466 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 911045001467 G1 box; other site 911045001468 putative GEF interaction site [polypeptide binding]; other site 911045001469 GTP/Mg2+ binding site [chemical binding]; other site 911045001470 Switch I region; other site 911045001471 G2 box; other site 911045001472 G3 box; other site 911045001473 Switch II region; other site 911045001474 G4 box; other site 911045001475 G5 box; other site 911045001476 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 911045001477 Translation-initiation factor 2; Region: IF-2; pfam11987 911045001478 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 911045001479 Ribosome-binding factor A; Region: RBFA; cl00542 911045001480 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 911045001481 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 911045001482 RNA binding site [nucleotide binding]; other site 911045001483 active site 911045001484 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 911045001485 16S/18S rRNA binding site [nucleotide binding]; other site 911045001486 S13e-L30e interaction site [polypeptide binding]; other site 911045001487 25S rRNA binding site [nucleotide binding]; other site 911045001488 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 911045001489 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 911045001490 RNase E interface [polypeptide binding]; other site 911045001491 trimer interface [polypeptide binding]; other site 911045001492 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 911045001493 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 911045001494 RNase E interface [polypeptide binding]; other site 911045001495 trimer interface [polypeptide binding]; other site 911045001496 active site 911045001497 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 911045001498 putative nucleic acid binding region [nucleotide binding]; other site 911045001499 G-X-X-G motif; other site 911045001500 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 911045001501 RNA binding site [nucleotide binding]; other site 911045001502 domain interface; other site 911045001503 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045001504 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045001505 dihydrodipicolinate reductase; Provisional; Region: PRK00048 911045001506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045001507 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 911045001508 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045001509 catalytic core [active] 911045001510 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 911045001511 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045001512 catalytic core [active] 911045001513 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 911045001514 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045001515 substrate binding site [chemical binding]; other site 911045001516 ATP binding site [chemical binding]; other site 911045001517 prephenate dehydratase; Provisional; Region: PRK11899 911045001518 Prephenate dehydratase; Region: PDT; pfam00800 911045001519 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 911045001520 putative L-Phe binding site [chemical binding]; other site 911045001521 Cytochrome c; Region: Cytochrom_C; cl11414 911045001522 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 911045001523 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 911045001524 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 911045001525 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 911045001526 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 911045001527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001528 dimer interface [polypeptide binding]; other site 911045001529 conserved gate region; other site 911045001530 putative PBP binding loops; other site 911045001531 ABC-ATPase subunit interface; other site 911045001532 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 911045001533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001534 dimer interface [polypeptide binding]; other site 911045001535 conserved gate region; other site 911045001536 putative PBP binding loops; other site 911045001537 ABC-ATPase subunit interface; other site 911045001538 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 911045001539 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045001540 Walker A/P-loop; other site 911045001541 ATP binding site [chemical binding]; other site 911045001542 Q-loop/lid; other site 911045001543 ABC transporter signature motif; other site 911045001544 Walker B; other site 911045001545 D-loop; other site 911045001546 H-loop/switch region; other site 911045001547 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045001548 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045001549 Walker A/P-loop; other site 911045001550 ATP binding site [chemical binding]; other site 911045001551 Q-loop/lid; other site 911045001552 ABC transporter signature motif; other site 911045001553 Walker B; other site 911045001554 D-loop; other site 911045001555 H-loop/switch region; other site 911045001556 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045001557 Phospholipid methyltransferase; Region: PEMT; cl00763 911045001558 LysE type translocator; Region: LysE; cl00565 911045001559 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 911045001560 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 911045001561 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 911045001562 P loop; other site 911045001563 GTP binding site [chemical binding]; other site 911045001564 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 911045001565 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 911045001566 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045001567 FeS/SAM binding site; other site 911045001568 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 911045001569 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 911045001570 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 911045001571 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 911045001572 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045001573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045001574 active site 911045001575 phosphorylation site [posttranslational modification] 911045001576 intermolecular recognition site; other site 911045001577 dimerization interface [polypeptide binding]; other site 911045001578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045001579 DNA binding site [nucleotide binding] 911045001580 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045001581 ligand binding site [chemical binding]; other site 911045001582 flexible hinge region; other site 911045001583 Helix-turn-helix domains; Region: HTH; cl00088 911045001584 LysE type translocator; Region: LysE; cl00565 911045001585 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 911045001586 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 911045001587 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 911045001588 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 911045001589 substrate binding site [chemical binding]; other site 911045001590 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 911045001591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045001592 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 911045001593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045001594 PQ loop repeat; Region: PQ-loop; cl12056 911045001595 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 911045001596 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045001597 pantothenate kinase; Provisional; Region: PRK05439 911045001598 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 911045001599 ATP-binding site [chemical binding]; other site 911045001600 CoA-binding site [chemical binding]; other site 911045001601 Mg2+-binding site [ion binding]; other site 911045001602 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 911045001603 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 911045001604 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 911045001605 substrate binding site [chemical binding]; other site 911045001606 glutamase interaction surface [polypeptide binding]; other site 911045001607 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 911045001608 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 911045001609 catalytic residues [active] 911045001610 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 911045001611 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 911045001612 putative active site [active] 911045001613 oxyanion strand; other site 911045001614 catalytic triad [active] 911045001615 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 911045001616 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 911045001617 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 911045001618 putative active site pocket [active] 911045001619 4-fold oligomerization interface [polypeptide binding]; other site 911045001620 metal binding residues [ion binding]; metal-binding site 911045001621 3-fold/trimer interface [polypeptide binding]; other site 911045001622 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 911045001623 active site 911045001624 dimer interface [polypeptide binding]; other site 911045001625 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 911045001626 putative substrate binding pocket [chemical binding]; other site 911045001627 AC domain interface; other site 911045001628 catalytic triad [active] 911045001629 AB domain interface; other site 911045001630 interchain disulfide; other site 911045001631 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045001632 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 911045001633 Nitrate and nitrite sensing; Region: NIT; pfam08376 911045001634 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045001635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045001636 dimer interface [polypeptide binding]; other site 911045001637 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 911045001638 putative CheW interface [polypeptide binding]; other site 911045001639 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 911045001640 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045001641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045001642 active site 911045001643 phosphorylation site [posttranslational modification] 911045001644 intermolecular recognition site; other site 911045001645 dimerization interface [polypeptide binding]; other site 911045001646 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045001647 DNA binding site [nucleotide binding] 911045001648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045001649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045001650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045001651 dimer interface [polypeptide binding]; other site 911045001652 phosphorylation site [posttranslational modification] 911045001653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045001654 ATP binding site [chemical binding]; other site 911045001655 Mg2+ binding site [ion binding]; other site 911045001656 G-X-G motif; other site 911045001657 GTPase RsgA; Reviewed; Region: PRK01889 911045001658 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 911045001659 GTPase/Zn-binding domain interface [polypeptide binding]; other site 911045001660 GTP/Mg2+ binding site [chemical binding]; other site 911045001661 G4 box; other site 911045001662 G5 box; other site 911045001663 G1 box; other site 911045001664 Switch I region; other site 911045001665 G2 box; other site 911045001666 G3 box; other site 911045001667 Switch II region; other site 911045001668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045001669 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 911045001670 SecA binding site; other site 911045001671 Preprotein binding site; other site 911045001672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045001673 dimer interface [polypeptide binding]; other site 911045001674 phosphorylation site [posttranslational modification] 911045001675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045001676 ATP binding site [chemical binding]; other site 911045001677 Mg2+ binding site [ion binding]; other site 911045001678 G-X-G motif; other site 911045001679 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 911045001680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045001681 active site 911045001682 phosphorylation site [posttranslational modification] 911045001683 intermolecular recognition site; other site 911045001684 dimerization interface [polypeptide binding]; other site 911045001685 Helix-turn-helix domains; Region: HTH; cl00088 911045001686 Intracellular septation protein A; Region: IspA; cl01098 911045001687 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045001688 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045001689 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 911045001690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045001691 S-adenosylmethionine binding site [chemical binding]; other site 911045001692 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045001693 ABC-ATPase subunit interface; other site 911045001694 dimer interface [polypeptide binding]; other site 911045001695 putative PBP binding regions; other site 911045001696 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 911045001697 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 911045001698 putative ligand binding residues [chemical binding]; other site 911045001699 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 911045001700 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 911045001701 Walker A/P-loop; other site 911045001702 ATP binding site [chemical binding]; other site 911045001703 Q-loop/lid; other site 911045001704 ABC transporter signature motif; other site 911045001705 Walker B; other site 911045001706 D-loop; other site 911045001707 H-loop/switch region; other site 911045001708 Predicted acetyltransferase [General function prediction only]; Region: COG3153 911045001709 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045001710 recombination protein RecR; Reviewed; Region: recR; PRK00076 911045001711 RecR protein; Region: RecR; pfam02132 911045001712 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 911045001713 putative active site [active] 911045001714 putative metal-binding site [ion binding]; other site 911045001715 tetramer interface [polypeptide binding]; other site 911045001716 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 911045001717 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 911045001718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045001719 Walker A motif; other site 911045001720 ATP binding site [chemical binding]; other site 911045001721 Walker B motif; other site 911045001722 arginine finger; other site 911045001723 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 911045001724 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 911045001725 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 911045001726 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 911045001727 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 911045001728 putative NADH binding site [chemical binding]; other site 911045001729 putative active site [active] 911045001730 nudix motif; other site 911045001731 putative metal binding site [ion binding]; other site 911045001732 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045001733 catalytic core [active] 911045001734 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 911045001735 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 911045001736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045001737 Coenzyme A binding pocket [chemical binding]; other site 911045001738 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 911045001739 NADP+ binding site [chemical binding]; other site 911045001740 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 911045001741 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 911045001742 proximal quinone binding site [chemical binding]; other site 911045001743 SdhD (CybS) interface [polypeptide binding]; other site 911045001744 proximal heme binding site [chemical binding]; other site 911045001745 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 911045001746 putative SdhC subunit interface [polypeptide binding]; other site 911045001747 putative proximal heme binding site [chemical binding]; other site 911045001748 putative Iron-sulfur protein interface [polypeptide binding]; other site 911045001749 putative proximal quinone binding site; other site 911045001750 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 911045001751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045001752 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 911045001753 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 911045001754 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 911045001755 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045001756 Helix-turn-helix domains; Region: HTH; cl00088 911045001757 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 911045001758 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 911045001759 MAPEG family; Region: MAPEG; cl09190 911045001760 Protease inhibitor Inh; Region: Inh; pfam02974 911045001761 Predicted ATPase [General function prediction only]; Region: COG1485 911045001762 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045001763 Walker A/P-loop; other site 911045001764 ATP binding site [chemical binding]; other site 911045001765 Q-loop/lid; other site 911045001766 ABC transporter signature motif; other site 911045001767 Walker B; other site 911045001768 D-loop; other site 911045001769 H-loop/switch region; other site 911045001770 malate dehydrogenase; Reviewed; Region: PRK06223 911045001771 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 911045001772 NAD(P) binding site [chemical binding]; other site 911045001773 dimer interface [polypeptide binding]; other site 911045001774 tetramer (dimer of dimers) interface [polypeptide binding]; other site 911045001775 substrate binding site [chemical binding]; other site 911045001776 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 911045001777 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045001778 CoA-ligase; Region: Ligase_CoA; cl02894 911045001779 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 911045001780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045001781 CoA-ligase; Region: Ligase_CoA; cl02894 911045001782 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 911045001783 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 911045001784 TPP-binding site [chemical binding]; other site 911045001785 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 911045001786 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 911045001787 E3 interaction surface; other site 911045001788 lipoyl attachment site [posttranslational modification]; other site 911045001789 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 911045001790 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 911045001791 E3 interaction surface; other site 911045001792 lipoyl attachment site [posttranslational modification]; other site 911045001793 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 911045001794 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 911045001795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045001796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 911045001797 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 911045001798 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 911045001799 thiamine phosphate binding site [chemical binding]; other site 911045001800 active site 911045001801 pyrophosphate binding site [ion binding]; other site 911045001802 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 911045001803 substrate binding site [chemical binding]; other site 911045001804 multimerization interface [polypeptide binding]; other site 911045001805 ATP binding site [chemical binding]; other site 911045001806 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 911045001807 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045001808 DNA binding site [nucleotide binding] 911045001809 Int/Topo IB signature motif; other site 911045001810 active site 911045001811 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 911045001812 PLD-like domain; Region: PLDc_2; pfam13091 911045001813 putative active site [active] 911045001814 catalytic site [active] 911045001815 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 911045001816 putative active site [active] 911045001817 catalytic site [active] 911045001818 Endonuclease I; Region: Endonuclease_1; cl01003 911045001819 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 911045001820 Protein of unknown function (DUF523); Region: DUF523; cl00733 911045001821 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 911045001822 active site 911045001823 intersubunit interactions; other site 911045001824 catalytic residue [active] 911045001825 primosome assembly protein PriA; Validated; Region: PRK05580 911045001826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045001827 ATP binding site [chemical binding]; other site 911045001828 putative Mg++ binding site [ion binding]; other site 911045001829 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045001830 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 911045001831 Plant ATP synthase F0; Region: YMF19; cl07975 911045001832 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 911045001833 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 911045001834 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 911045001835 beta subunit interaction interface [polypeptide binding]; other site 911045001836 Walker A motif; other site 911045001837 ATP binding site [chemical binding]; other site 911045001838 Walker B motif; other site 911045001839 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 911045001840 ATP synthase; Region: ATP-synt; cl00365 911045001841 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 911045001842 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 911045001843 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 911045001844 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 911045001845 alpha subunit interaction interface [polypeptide binding]; other site 911045001846 Walker A motif; other site 911045001847 ATP binding site [chemical binding]; other site 911045001848 Walker B motif; other site 911045001849 inhibitor binding site; inhibition site 911045001850 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 911045001851 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 911045001852 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 911045001853 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 911045001854 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 911045001855 putative MPT binding site; other site 911045001856 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 911045001857 Ligand binding site; other site 911045001858 metal-binding site 911045001859 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 911045001860 XdhC Rossmann domain; Region: XdhC_C; pfam13478 911045001861 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 911045001862 active site 911045001863 substrate-binding site [chemical binding]; other site 911045001864 metal-binding site [ion binding] 911045001865 ATP binding site [chemical binding]; other site 911045001866 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045001867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045001868 active site 911045001869 phosphorylation site [posttranslational modification] 911045001870 intermolecular recognition site; other site 911045001871 dimerization interface [polypeptide binding]; other site 911045001872 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045001873 DNA binding site [nucleotide binding] 911045001874 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 911045001875 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 911045001876 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045001877 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045001878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045001879 dimer interface [polypeptide binding]; other site 911045001880 phosphorylation site [posttranslational modification] 911045001881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045001882 ATP binding site [chemical binding]; other site 911045001883 Mg2+ binding site [ion binding]; other site 911045001884 G-X-G motif; other site 911045001885 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 911045001886 Hpr binding site; other site 911045001887 active site 911045001888 homohexamer subunit interaction site [polypeptide binding]; other site 911045001889 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 911045001890 active pocket/dimerization site; other site 911045001891 active site 911045001892 phosphorylation site [posttranslational modification] 911045001893 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 911045001894 dimerization domain swap beta strand [polypeptide binding]; other site 911045001895 regulatory protein interface [polypeptide binding]; other site 911045001896 active site 911045001897 regulatory phosphorylation site [posttranslational modification]; other site 911045001898 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045001899 nudix motif; other site 911045001900 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 911045001901 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 911045001902 oligomerization interface [polypeptide binding]; other site 911045001903 active site 911045001904 NAD+ binding site [chemical binding]; other site 911045001905 PAS fold; Region: PAS_7; pfam12860 911045001906 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 911045001907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045001908 dimer interface [polypeptide binding]; other site 911045001909 phosphorylation site [posttranslational modification] 911045001910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045001911 ATP binding site [chemical binding]; other site 911045001912 Mg2+ binding site [ion binding]; other site 911045001913 G-X-G motif; other site 911045001914 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 911045001915 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045001916 Phosphotransferase enzyme family; Region: APH; pfam01636 911045001917 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 911045001918 Substrate binding site; other site 911045001919 metal-binding site 911045001920 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045001921 active site 911045001922 metal binding site [ion binding]; metal-binding site 911045001923 Helix-turn-helix domains; Region: HTH; cl00088 911045001924 Helix-turn-helix domains; Region: HTH; cl00088 911045001925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045001926 Coenzyme A binding pocket [chemical binding]; other site 911045001927 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 911045001928 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 911045001929 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 911045001930 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 911045001931 Family description; Region: UvrD_C_2; cl15862 911045001932 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 911045001933 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 911045001934 catalytic residues [active] 911045001935 heat shock protein GrpE; Provisional; Region: PRK14141 911045001936 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 911045001937 dimer interface [polypeptide binding]; other site 911045001938 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 911045001939 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 911045001940 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045001941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045001942 Helix-turn-helix domains; Region: HTH; cl00088 911045001943 Predicted membrane protein [Function unknown]; Region: COG2860 911045001944 UPF0126 domain; Region: UPF0126; pfam03458 911045001945 UPF0126 domain; Region: UPF0126; pfam03458 911045001946 ornithine cyclodeaminase; Validated; Region: PRK06141 911045001947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045001948 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 911045001949 IHF dimer interface [polypeptide binding]; other site 911045001950 IHF - DNA interface [nucleotide binding]; other site 911045001951 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 911045001952 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 911045001953 tandem repeat interface [polypeptide binding]; other site 911045001954 oligomer interface [polypeptide binding]; other site 911045001955 active site residues [active] 911045001956 Chorismate mutase type II; Region: CM_2; cl00693 911045001957 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 911045001958 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 911045001959 putative NAD(P) binding site [chemical binding]; other site 911045001960 putative active site [active] 911045001961 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 911045001962 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045001963 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 911045001964 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 911045001965 RNA binding site [nucleotide binding]; other site 911045001966 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 911045001967 RNA binding site [nucleotide binding]; other site 911045001968 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 911045001969 RNA binding site [nucleotide binding]; other site 911045001970 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 911045001971 RNA binding site [nucleotide binding]; other site 911045001972 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 911045001973 RNA binding site [nucleotide binding]; other site 911045001974 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 911045001975 RNA binding site [nucleotide binding]; other site 911045001976 cytidylate kinase; Provisional; Region: cmk; PRK00023 911045001977 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 911045001978 CMP-binding site; other site 911045001979 The sites determining sugar specificity; other site 911045001980 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 911045001981 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 911045001982 hinge; other site 911045001983 active site 911045001984 TIGR02300 family protein; Region: FYDLN_acid 911045001985 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 911045001986 DNA photolyase; Region: DNA_photolyase; pfam00875 911045001987 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 911045001988 Fasciclin domain; Region: Fasciclin; cl02663 911045001989 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045001990 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045001991 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 911045001992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001993 dimer interface [polypeptide binding]; other site 911045001994 conserved gate region; other site 911045001995 putative PBP binding loops; other site 911045001996 ABC-ATPase subunit interface; other site 911045001997 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045001998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001999 dimer interface [polypeptide binding]; other site 911045002000 conserved gate region; other site 911045002001 putative PBP binding loops; other site 911045002002 ABC-ATPase subunit interface; other site 911045002003 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045002004 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045002005 Walker A/P-loop; other site 911045002006 ATP binding site [chemical binding]; other site 911045002007 Q-loop/lid; other site 911045002008 ABC transporter signature motif; other site 911045002009 Walker B; other site 911045002010 D-loop; other site 911045002011 H-loop/switch region; other site 911045002012 TOBE domain; Region: TOBE_2; cl01440 911045002013 putative heme utilization radical SAM enzyme HutW; Region: rSAM_HutW; TIGR04107 911045002014 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045002015 FeS/SAM binding site; other site 911045002016 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 911045002017 MAPEG family; Region: MAPEG; cl09190 911045002018 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 911045002019 putative dimer interface [polypeptide binding]; other site 911045002020 Protein of unknown function (DUF1150); Region: DUF1150; cl11577 911045002021 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 911045002022 active site 911045002023 phosphorylation site [posttranslational modification] 911045002024 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 911045002025 30S subunit binding site; other site 911045002026 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 911045002027 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 911045002028 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 911045002029 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 911045002030 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 911045002031 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 911045002032 Walker A/P-loop; other site 911045002033 ATP binding site [chemical binding]; other site 911045002034 Q-loop/lid; other site 911045002035 ABC transporter signature motif; other site 911045002036 Walker B; other site 911045002037 D-loop; other site 911045002038 H-loop/switch region; other site 911045002039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 911045002040 OstA-like protein; Region: OstA; cl00844 911045002041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 911045002042 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 911045002043 putative active site [active] 911045002044 catalytic site [active] 911045002045 putative substrate binding site [chemical binding]; other site 911045002046 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 911045002047 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 911045002048 putative NAD(P) binding site [chemical binding]; other site 911045002049 active site 911045002050 Bacitracin resistance protein BacA; Region: BacA; cl00858 911045002051 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045002052 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 911045002053 N-terminal domain interface [polypeptide binding]; other site 911045002054 dimer interface [polypeptide binding]; other site 911045002055 substrate binding pocket (H-site) [chemical binding]; other site 911045002056 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 911045002057 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 911045002058 HEAT repeat; Region: HEAT; pfam02985 911045002059 short chain dehydrogenase; Provisional; Region: PRK06197 911045002060 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 911045002061 putative NAD(P) binding site [chemical binding]; other site 911045002062 active site 911045002063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045002064 Helix-turn-helix domains; Region: HTH; cl00088 911045002065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045002066 non-specific DNA binding site [nucleotide binding]; other site 911045002067 salt bridge; other site 911045002068 sequence-specific DNA binding site [nucleotide binding]; other site 911045002069 2TM domain; Region: 2TM; pfam13239 911045002070 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 911045002071 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045002072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045002073 homodimer interface [polypeptide binding]; other site 911045002074 catalytic residue [active] 911045002075 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045002076 Helix-turn-helix domains; Region: HTH; cl00088 911045002077 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 911045002078 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 911045002079 putative active site [active] 911045002080 Ap4A binding site [chemical binding]; other site 911045002081 nudix motif; other site 911045002082 putative metal binding site [ion binding]; other site 911045002083 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 911045002084 NodB motif; other site 911045002085 putative active site [active] 911045002086 putative catalytic site [active] 911045002087 Zn binding site [ion binding]; other site 911045002088 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 911045002089 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 911045002090 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 911045002091 protein binding site [polypeptide binding]; other site 911045002092 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 911045002093 Catalytic dyad [active] 911045002094 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 911045002095 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 911045002096 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 911045002097 Oligomerisation domain; Region: Oligomerisation; cl00519 911045002098 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 911045002099 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 911045002100 active site 911045002101 (T/H)XGH motif; other site 911045002102 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 911045002103 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 911045002104 putative catalytic cysteine [active] 911045002105 gamma-glutamyl kinase; Provisional; Region: PRK05429 911045002106 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 911045002107 nucleotide binding site [chemical binding]; other site 911045002108 homotetrameric interface [polypeptide binding]; other site 911045002109 putative phosphate binding site [ion binding]; other site 911045002110 putative allosteric binding site; other site 911045002111 PUA domain; Region: PUA; cl00607 911045002112 GTPase CgtA; Reviewed; Region: obgE; PRK12299 911045002113 GTP1/OBG; Region: GTP1_OBG; pfam01018 911045002114 Obg GTPase; Region: Obg; cd01898 911045002115 G1 box; other site 911045002116 GTP/Mg2+ binding site [chemical binding]; other site 911045002117 Switch I region; other site 911045002118 G2 box; other site 911045002119 G3 box; other site 911045002120 Switch II region; other site 911045002121 G4 box; other site 911045002122 G5 box; other site 911045002123 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002124 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045002125 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 911045002126 DNA-binding site [nucleotide binding]; DNA binding site 911045002127 RNA-binding motif; other site 911045002128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045002129 Helix-turn-helix domains; Region: HTH; cl00088 911045002130 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 911045002131 OsmC-like protein; Region: OsmC; cl00767 911045002132 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002133 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045002134 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002135 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045002136 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002137 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045002138 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002139 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045002140 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002141 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045002142 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002143 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045002144 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002145 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045002146 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045002147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002148 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045002149 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 911045002150 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 911045002151 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 911045002152 Uncharacterized conserved protein [Function unknown]; Region: COG3743 911045002153 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045002154 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 911045002155 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045002156 dimer interface [polypeptide binding]; other site 911045002157 putative CheW interface [polypeptide binding]; other site 911045002158 HsdM N-terminal domain; Region: HsdM_N; pfam12161 911045002159 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 911045002160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002161 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 911045002162 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 911045002163 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 911045002164 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 911045002165 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045002166 Protein of unknown function DUF45; Region: DUF45; cl00636 911045002167 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002168 Helix-turn-helix domains; Region: HTH; cl00088 911045002169 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 911045002170 dimerization interface [polypeptide binding]; other site 911045002171 substrate binding pocket [chemical binding]; other site 911045002172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002173 active site 911045002174 NAD+ binding site [chemical binding]; other site 911045002175 oligomerization interface [polypeptide binding]; other site 911045002176 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 911045002177 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 911045002178 Nucleoside recognition; Region: Gate; cl00486 911045002179 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 911045002180 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 911045002181 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 911045002182 active site 911045002183 metal binding site [ion binding]; metal-binding site 911045002184 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 911045002185 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 911045002186 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 911045002187 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 911045002188 DNA-binding interface [nucleotide binding]; DNA binding site 911045002189 Helix-turn-helix domains; Region: HTH; cl00088 911045002190 integrase; Provisional; Region: PRK09692 911045002191 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 911045002192 active site 911045002193 Int/Topo IB signature motif; other site 911045002194 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 911045002195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045002196 S-adenosylmethionine binding site [chemical binding]; other site 911045002197 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045002198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002199 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 911045002200 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 911045002201 xanthine permease; Region: pbuX; TIGR03173 911045002202 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 911045002203 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 911045002204 hypothetical protein; Provisional; Region: PRK11171 911045002205 Cupin domain; Region: Cupin_2; cl09118 911045002206 Cupin domain; Region: Cupin_2; cl09118 911045002207 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002208 Helix-turn-helix domains; Region: HTH; cl00088 911045002209 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045002210 putative effector binding pocket; other site 911045002211 dimerization interface [polypeptide binding]; other site 911045002212 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 911045002213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045002214 putative substrate translocation pore; other site 911045002215 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 911045002216 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 911045002217 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 911045002218 [4Fe-4S] binding site [ion binding]; other site 911045002219 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 911045002220 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 911045002221 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 911045002222 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 911045002223 molybdopterin cofactor binding site; other site 911045002224 nitrate reductase, beta subunit; Region: narH; TIGR01660 911045002225 4Fe-4S binding domain; Region: Fer4; cl02805 911045002226 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 911045002227 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 911045002228 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 911045002229 PPIC-type PPIASE domain; Region: Rotamase; cl08278 911045002230 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045002231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002232 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 911045002233 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 911045002234 putative ligand binding site [chemical binding]; other site 911045002235 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 911045002236 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 911045002237 Walker A/P-loop; other site 911045002238 ATP binding site [chemical binding]; other site 911045002239 Q-loop/lid; other site 911045002240 ABC transporter signature motif; other site 911045002241 Walker B; other site 911045002242 D-loop; other site 911045002243 H-loop/switch region; other site 911045002244 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 911045002245 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045002246 TM-ABC transporter signature motif; other site 911045002247 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045002248 TM-ABC transporter signature motif; other site 911045002249 cytosine deaminase; Validated; Region: PRK07572 911045002250 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 911045002251 active site 911045002252 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045002253 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 911045002254 FMN binding site [chemical binding]; other site 911045002255 dimer interface [polypeptide binding]; other site 911045002256 Flagellar protein FliS; Region: FliS; cl00654 911045002257 NIPSNAP; Region: NIPSNAP; pfam07978 911045002258 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 911045002259 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 911045002260 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 911045002261 ornithine cyclodeaminase; Validated; Region: PRK07589 911045002262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002263 Arginase family; Region: Arginase; cl00306 911045002264 Helix-turn-helix domains; Region: HTH; cl00088 911045002265 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 911045002266 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 911045002267 putative NAD(P) binding site [chemical binding]; other site 911045002268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002269 Helix-turn-helix domains; Region: HTH; cl00088 911045002270 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045002271 putative effector binding pocket; other site 911045002272 dimerization interface [polypeptide binding]; other site 911045002273 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 911045002274 Helix-turn-helix domains; Region: HTH; cl00088 911045002275 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 911045002276 substrate binding pocket [chemical binding]; other site 911045002277 dimerization interface [polypeptide binding]; other site 911045002278 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 911045002279 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 911045002280 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 911045002281 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045002282 ligand binding site [chemical binding]; other site 911045002283 flexible hinge region; other site 911045002284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045002285 S-adenosylmethionine binding site [chemical binding]; other site 911045002286 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 911045002287 Cupin domain; Region: Cupin_2; cl09118 911045002288 Cupin domain; Region: Cupin_2; cl09118 911045002289 Helix-turn-helix domain; Region: HTH_18; pfam12833 911045002290 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045002291 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045002292 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 911045002293 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 911045002294 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 911045002295 cell division protein ZipA; Provisional; Region: PRK03427 911045002296 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045002297 MatE; Region: MatE; cl10513 911045002298 Cupin domain; Region: Cupin_2; cl09118 911045002299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045002300 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045002301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045002302 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 911045002303 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 911045002304 MOFRL family; Region: MOFRL; pfam05161 911045002305 Proline racemase; Region: Pro_racemase; pfam05544 911045002306 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 911045002307 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 911045002308 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 911045002309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045002310 DNA-binding site [nucleotide binding]; DNA binding site 911045002311 FCD domain; Region: FCD; cl11656 911045002312 Peptidase family U32; Region: Peptidase_U32; cl03113 911045002313 Peptidase family U32; Region: Peptidase_U32; cl03113 911045002314 SCP-2 sterol transfer family; Region: SCP2; cl01225 911045002315 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 911045002316 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 911045002317 Flavoprotein; Region: Flavoprotein; cl08021 911045002318 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 911045002319 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 911045002320 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 911045002321 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 911045002322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045002323 putative substrate translocation pore; other site 911045002324 guanine deaminase; Provisional; Region: PRK09228 911045002325 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 911045002326 active site 911045002327 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 911045002328 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 911045002329 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 911045002330 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 911045002331 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 911045002332 putative active site [active] 911045002333 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 911045002334 putative active site [active] 911045002335 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 911045002336 Precorrin-8X methylmutase; Region: CbiC; pfam02570 911045002337 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 911045002338 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 911045002339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 911045002340 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 911045002341 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 911045002342 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 911045002343 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 911045002344 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 911045002345 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 911045002346 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 911045002347 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 911045002348 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 911045002349 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 911045002350 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045002351 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 911045002352 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 911045002353 CbiD; Region: CbiD; cl00828 911045002354 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 911045002355 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 911045002356 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 911045002357 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 911045002358 dimer interface [polypeptide binding]; other site 911045002359 ADP-ribose binding site [chemical binding]; other site 911045002360 active site 911045002361 nudix motif; other site 911045002362 metal binding site [ion binding]; metal-binding site 911045002363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002364 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 911045002365 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 911045002366 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 911045002367 putative NAD(P) binding site [chemical binding]; other site 911045002368 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 911045002369 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045002370 active site 911045002371 OpgC protein; Region: OpgC_C; cl00792 911045002372 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 911045002373 putative inner membrane protein; Provisional; Region: PRK11099 911045002374 Sulphur transport; Region: Sulf_transp; cl01018 911045002375 Domain of unknown function DUF302; Region: DUF302; cl01364 911045002376 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 911045002377 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045002378 PYR/PP interface [polypeptide binding]; other site 911045002379 dimer interface [polypeptide binding]; other site 911045002380 TPP binding site [chemical binding]; other site 911045002381 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 911045002382 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 911045002383 TPP-binding site [chemical binding]; other site 911045002384 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 911045002385 CoA-transferase family III; Region: CoA_transf_3; pfam02515 911045002386 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045002387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002388 NAD(P) binding site [chemical binding]; other site 911045002389 active site 911045002390 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045002391 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045002392 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045002393 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 911045002394 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045002395 ligand binding site [chemical binding]; other site 911045002396 CAAX protease self-immunity; Region: Abi; cl00558 911045002397 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045002398 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 911045002399 Walker A/P-loop; other site 911045002400 ATP binding site [chemical binding]; other site 911045002401 Q-loop/lid; other site 911045002402 ABC transporter signature motif; other site 911045002403 Walker B; other site 911045002404 D-loop; other site 911045002405 H-loop/switch region; other site 911045002406 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 911045002407 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 911045002408 Walker A/P-loop; other site 911045002409 ATP binding site [chemical binding]; other site 911045002410 Q-loop/lid; other site 911045002411 ABC transporter signature motif; other site 911045002412 Walker B; other site 911045002413 D-loop; other site 911045002414 H-loop/switch region; other site 911045002415 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045002416 TM-ABC transporter signature motif; other site 911045002417 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045002418 TM-ABC transporter signature motif; other site 911045002419 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 911045002420 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 911045002421 putative ligand binding site [chemical binding]; other site 911045002422 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 911045002423 heme-binding site [chemical binding]; other site 911045002424 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045002425 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045002426 dimer interface [polypeptide binding]; other site 911045002427 putative CheW interface [polypeptide binding]; other site 911045002428 Helix-turn-helix domains; Region: HTH; cl00088 911045002429 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 911045002430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045002431 dimerization interface [polypeptide binding]; other site 911045002432 PAS fold; Region: PAS_7; pfam12860 911045002433 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045002434 metal binding site [ion binding]; metal-binding site 911045002435 active site 911045002436 I-site; other site 911045002437 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045002438 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045002439 catalytic loop [active] 911045002440 iron binding site [ion binding]; other site 911045002441 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 911045002442 FAD binding pocket [chemical binding]; other site 911045002443 conserved FAD binding motif [chemical binding]; other site 911045002444 phosphate binding motif [ion binding]; other site 911045002445 beta-alpha-beta structure motif; other site 911045002446 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 911045002447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 911045002448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045002449 S-adenosylmethionine binding site [chemical binding]; other site 911045002450 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 911045002451 intracellular protease, PfpI family; Region: PfpI; TIGR01382 911045002452 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 911045002453 conserved cys residue [active] 911045002454 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 911045002455 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 911045002456 active site 911045002457 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045002458 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 911045002459 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 911045002460 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045002461 homotrimer interaction site [polypeptide binding]; other site 911045002462 putative active site [active] 911045002463 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045002464 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 911045002465 conserved cys residue [active] 911045002466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045002467 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045002468 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 911045002469 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 911045002470 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 911045002471 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 911045002472 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 911045002473 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 911045002474 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045002475 active site 911045002476 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 911045002477 active site 911045002478 substrate binding pocket [chemical binding]; other site 911045002479 dimer interface [polypeptide binding]; other site 911045002480 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 911045002481 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 911045002482 Creatinine amidohydrolase; Region: Creatininase; cl00618 911045002483 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045002484 Amidinotransferase; Region: Amidinotransf; cl12043 911045002485 Cupin domain; Region: Cupin_2; cl09118 911045002486 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045002487 NnrS protein; Region: NnrS; cl01258 911045002488 GSCFA family; Region: GSCFA; pfam08885 911045002489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045002490 binding surface 911045002491 TPR motif; other site 911045002492 Cytochrome c; Region: Cytochrom_C; cl11414 911045002493 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 911045002494 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045002495 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 911045002496 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 911045002497 putative ligand binding site [chemical binding]; other site 911045002498 Cytochrome c; Region: Cytochrom_C; cl11414 911045002499 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 911045002500 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 911045002501 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 911045002502 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 911045002503 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045002504 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045002505 Walker A/P-loop; other site 911045002506 ATP binding site [chemical binding]; other site 911045002507 Q-loop/lid; other site 911045002508 ABC transporter signature motif; other site 911045002509 Walker B; other site 911045002510 D-loop; other site 911045002511 H-loop/switch region; other site 911045002512 TOBE domain; Region: TOBE_2; cl01440 911045002513 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045002514 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045002515 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 911045002516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045002517 dimer interface [polypeptide binding]; other site 911045002518 conserved gate region; other site 911045002519 putative PBP binding loops; other site 911045002520 ABC-ATPase subunit interface; other site 911045002521 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045002522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045002523 dimer interface [polypeptide binding]; other site 911045002524 conserved gate region; other site 911045002525 putative PBP binding loops; other site 911045002526 ABC-ATPase subunit interface; other site 911045002527 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 911045002528 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 911045002529 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045002530 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045002531 DNA binding site [nucleotide binding] 911045002532 domain linker motif; other site 911045002533 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 911045002534 ligand binding site [chemical binding]; other site 911045002535 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 911045002536 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 911045002537 ATP binding site [chemical binding]; other site 911045002538 substrate interface [chemical binding]; other site 911045002539 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 911045002540 active site residue [active] 911045002541 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 911045002542 thiamine phosphate binding site [chemical binding]; other site 911045002543 active site 911045002544 pyrophosphate binding site [ion binding]; other site 911045002545 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 911045002546 ThiS interaction site; other site 911045002547 putative active site [active] 911045002548 tetramer interface [polypeptide binding]; other site 911045002549 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 911045002550 thiS-thiF/thiG interaction site; other site 911045002551 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 911045002552 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 911045002553 ThiC-associated domain; Region: ThiC-associated; pfam13667 911045002554 ThiC family; Region: ThiC; cl08031 911045002555 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 911045002556 metal binding site [ion binding]; metal-binding site 911045002557 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 911045002558 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 911045002559 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 911045002560 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 911045002561 putative active site [active] 911045002562 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045002563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045002564 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045002565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045002566 dimer interface [polypeptide binding]; other site 911045002567 conserved gate region; other site 911045002568 putative PBP binding loops; other site 911045002569 ABC-ATPase subunit interface; other site 911045002570 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045002571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045002572 dimer interface [polypeptide binding]; other site 911045002573 conserved gate region; other site 911045002574 putative PBP binding loops; other site 911045002575 ABC-ATPase subunit interface; other site 911045002576 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045002577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002578 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045002579 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045002580 Walker A/P-loop; other site 911045002581 ATP binding site [chemical binding]; other site 911045002582 Q-loop/lid; other site 911045002583 ABC transporter signature motif; other site 911045002584 Walker B; other site 911045002585 D-loop; other site 911045002586 H-loop/switch region; other site 911045002587 TOBE domain; Region: TOBE_2; cl01440 911045002588 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 911045002589 Helix-turn-helix domains; Region: HTH; cl00088 911045002590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045002591 dimerization interface [polypeptide binding]; other site 911045002592 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 911045002593 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 911045002594 Nucleoside recognition; Region: Gate; cl00486 911045002595 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 911045002596 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 911045002597 Helix-turn-helix domains; Region: HTH; cl00088 911045002598 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045002599 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045002600 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045002601 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045002602 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045002603 urocanate hydratase; Provisional; Region: PRK05414 911045002604 N-formylglutamate amidohydrolase; Region: FGase; cl01522 911045002605 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 911045002606 active sites [active] 911045002607 tetramer interface [polypeptide binding]; other site 911045002608 imidazolonepropionase; Validated; Region: PRK09356 911045002609 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 911045002610 active site 911045002611 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 911045002612 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 911045002613 active site 911045002614 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 911045002615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045002616 DNA-binding site [nucleotide binding]; DNA binding site 911045002617 UTRA domain; Region: UTRA; cl01230 911045002618 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 911045002619 NADH(P)-binding; Region: NAD_binding_10; pfam13460 911045002620 NAD(P) binding site [chemical binding]; other site 911045002621 putative active site [active] 911045002622 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 911045002623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045002624 putative PBP binding loops; other site 911045002625 ABC-ATPase subunit interface; other site 911045002626 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 911045002627 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 911045002628 Walker A/P-loop; other site 911045002629 ATP binding site [chemical binding]; other site 911045002630 Q-loop/lid; other site 911045002631 ABC transporter signature motif; other site 911045002632 Walker B; other site 911045002633 D-loop; other site 911045002634 H-loop/switch region; other site 911045002635 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 911045002636 NMT1-like family; Region: NMT1_2; cl15260 911045002637 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 911045002638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045002639 DNA-binding site [nucleotide binding]; DNA binding site 911045002640 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045002641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045002642 homodimer interface [polypeptide binding]; other site 911045002643 catalytic residue [active] 911045002644 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 911045002645 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045002646 inhibitor-cofactor binding pocket; inhibition site 911045002647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045002648 catalytic residue [active] 911045002649 FAD dependent oxidoreductase; Region: DAO; pfam01266 911045002650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002651 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 911045002652 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 911045002653 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045002654 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 911045002655 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045002656 PYR/PP interface [polypeptide binding]; other site 911045002657 dimer interface [polypeptide binding]; other site 911045002658 TPP binding site [chemical binding]; other site 911045002659 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 911045002660 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 911045002661 TPP-binding site [chemical binding]; other site 911045002662 aminodeoxychorismate synthase; Provisional; Region: PRK07508 911045002663 chorismate binding enzyme; Region: Chorismate_bind; cl10555 911045002664 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 911045002665 substrate-cofactor binding pocket; other site 911045002666 homodimer interface [polypeptide binding]; other site 911045002667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045002668 catalytic residue [active] 911045002669 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045002670 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045002671 dimer interface [polypeptide binding]; other site 911045002672 putative CheW interface [polypeptide binding]; other site 911045002673 Helix-turn-helix domains; Region: HTH; cl00088 911045002674 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 911045002675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002676 Helix-turn-helix domains; Region: HTH; cl00088 911045002677 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045002678 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045002679 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 911045002680 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 911045002681 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 911045002682 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045002683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002684 NAD(P) binding site [chemical binding]; other site 911045002685 active site 911045002686 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 911045002687 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 911045002688 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 911045002689 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 911045002690 dimer interface [polypeptide binding]; other site 911045002691 motif 1; other site 911045002692 active site 911045002693 motif 2; other site 911045002694 motif 3; other site 911045002695 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 911045002696 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 911045002697 putative tRNA-binding site [nucleotide binding]; other site 911045002698 B3/4 domain; Region: B3_4; cl11458 911045002699 tRNA synthetase B5 domain; Region: B5; cl08394 911045002700 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 911045002701 dimer interface [polypeptide binding]; other site 911045002702 motif 1; other site 911045002703 motif 3; other site 911045002704 motif 2; other site 911045002705 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 911045002706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 911045002707 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 911045002708 tyrosine phenol-lyase; Provisional; Region: PRK13237 911045002709 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 911045002710 substrate binding site [chemical binding]; other site 911045002711 tetramer interface [polypeptide binding]; other site 911045002712 catalytic residue [active] 911045002713 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 911045002714 aromatic amino acid transport protein; Region: araaP; TIGR00837 911045002715 Uncharacterized conserved protein [Function unknown]; Region: COG3482 911045002716 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 911045002717 YcaO-like family; Region: YcaO; pfam02624 911045002718 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045002719 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045002720 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 911045002721 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 911045002722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002723 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045002724 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 911045002725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045002726 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045002727 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 911045002728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002729 NAD(P) binding site [chemical binding]; other site 911045002730 active site 911045002731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002732 Helix-turn-helix domains; Region: HTH; cl00088 911045002733 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045002734 dimerization interface [polypeptide binding]; other site 911045002735 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 911045002736 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 911045002737 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045002738 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 911045002739 PhnA protein; Region: PhnA; pfam03831 911045002740 GTP-binding protein LepA; Provisional; Region: PRK05433 911045002741 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 911045002742 G1 box; other site 911045002743 putative GEF interaction site [polypeptide binding]; other site 911045002744 GTP/Mg2+ binding site [chemical binding]; other site 911045002745 Switch I region; other site 911045002746 G2 box; other site 911045002747 G3 box; other site 911045002748 Switch II region; other site 911045002749 G4 box; other site 911045002750 G5 box; other site 911045002751 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 911045002752 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 911045002753 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 911045002754 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045002755 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 911045002756 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045002757 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 911045002758 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 911045002759 active site 911045002760 nucleophile elbow; other site 911045002761 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045002762 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002763 Helix-turn-helix domains; Region: HTH; cl00088 911045002764 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 911045002765 substrate binding pocket [chemical binding]; other site 911045002766 dimerization interface [polypeptide binding]; other site 911045002767 classical (c) SDRs; Region: SDR_c; cd05233 911045002768 NAD(P) binding site [chemical binding]; other site 911045002769 active site 911045002770 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 911045002771 active site 911045002772 multimer interface [polypeptide binding]; other site 911045002773 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 911045002774 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045002775 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045002776 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045002777 active site 911045002778 metal binding site [ion binding]; metal-binding site 911045002779 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002780 Helix-turn-helix domains; Region: HTH; cl00088 911045002781 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045002782 dimerization interface [polypeptide binding]; other site 911045002783 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045002784 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045002785 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 911045002786 putative ADP-binding pocket [chemical binding]; other site 911045002787 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 911045002788 translation initiation factor IF-3; Region: infC; TIGR00168 911045002789 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 911045002790 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 911045002791 nucleoside/Zn binding site; other site 911045002792 dimer interface [polypeptide binding]; other site 911045002793 catalytic motif [active] 911045002794 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 911045002795 nucleoside/Zn binding site; other site 911045002796 dimer interface [polypeptide binding]; other site 911045002797 catalytic motif [active] 911045002798 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 911045002799 ribosomal protein L20; Region: rpl20; CHL00068 911045002800 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 911045002801 23S rRNA binding site [nucleotide binding]; other site 911045002802 L21 binding site [polypeptide binding]; other site 911045002803 L13 binding site [polypeptide binding]; other site 911045002804 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045002805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045002806 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 911045002807 substrate binding site [chemical binding]; other site 911045002808 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 911045002809 putative acetyltransferase; Provisional; Region: PRK03624 911045002810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045002811 Coenzyme A binding pocket [chemical binding]; other site 911045002812 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045002813 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045002814 dimer interface [polypeptide binding]; other site 911045002815 putative CheW interface [polypeptide binding]; other site 911045002816 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045002817 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 911045002818 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 911045002819 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 911045002820 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 911045002821 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045002822 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 911045002823 putative NAD(P) binding site [chemical binding]; other site 911045002824 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 911045002825 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 911045002826 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 911045002827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045002828 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 911045002829 putative hydrophobic ligand binding site [chemical binding]; other site 911045002830 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 911045002831 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 911045002832 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 911045002833 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 911045002834 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 911045002835 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045002836 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 911045002837 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 911045002838 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045002839 classical (c) SDRs; Region: SDR_c; cd05233 911045002840 NAD(P) binding site [chemical binding]; other site 911045002841 active site 911045002842 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 911045002843 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 911045002844 heme binding site [chemical binding]; other site 911045002845 ferroxidase pore; other site 911045002846 ferroxidase diiron center [ion binding]; other site 911045002847 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 911045002848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045002849 ATP binding site [chemical binding]; other site 911045002850 putative Mg++ binding site [ion binding]; other site 911045002851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045002852 nucleotide binding region [chemical binding]; other site 911045002853 ATP-binding site [chemical binding]; other site 911045002854 Helicase associated domain (HA2); Region: HA2; cl04503 911045002855 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 911045002856 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 911045002857 glucokinase, proteobacterial type; Region: glk; TIGR00749 911045002858 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 911045002859 active site 911045002860 dimer interfaces [polypeptide binding]; other site 911045002861 catalytic residues [active] 911045002862 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 911045002863 Helix-turn-helix domains; Region: HTH; cl00088 911045002864 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 911045002865 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 911045002866 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 911045002867 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 911045002868 ligand binding site [chemical binding]; other site 911045002869 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 911045002870 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045002871 Walker A/P-loop; other site 911045002872 ATP binding site [chemical binding]; other site 911045002873 Q-loop/lid; other site 911045002874 ABC transporter signature motif; other site 911045002875 Walker B; other site 911045002876 D-loop; other site 911045002877 H-loop/switch region; other site 911045002878 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 911045002879 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045002880 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045002881 TM-ABC transporter signature motif; other site 911045002882 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045002883 TM-ABC transporter signature motif; other site 911045002884 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 911045002885 active site 911045002886 catalytic motif [active] 911045002887 Zn binding site [ion binding]; other site 911045002888 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 911045002889 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 911045002890 intersubunit interface [polypeptide binding]; other site 911045002891 active site 911045002892 catalytic residue [active] 911045002893 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 911045002894 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 911045002895 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 911045002896 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 911045002897 Sulfatase; Region: Sulfatase; cl10460 911045002898 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 911045002899 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 911045002900 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 911045002901 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 911045002902 active site 911045002903 purine riboside binding site [chemical binding]; other site 911045002904 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 911045002905 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045002906 active site 911045002907 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 911045002908 active site 911045002909 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 911045002910 catalytic motif [active] 911045002911 Catalytic residue [active] 911045002912 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 911045002913 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 911045002914 active site 911045002915 catalytic residues [active] 911045002916 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 911045002917 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 911045002918 Protein of unknown function (DUF805); Region: DUF805; cl01224 911045002919 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 911045002920 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 911045002921 metal binding site [ion binding]; metal-binding site 911045002922 dimer interface [polypeptide binding]; other site 911045002923 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 911045002924 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 911045002925 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 911045002926 dimerization interface 3.5A [polypeptide binding]; other site 911045002927 active site 911045002928 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045002929 Predicted acetyltransferase [General function prediction only]; Region: COG3153 911045002930 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 911045002931 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 911045002932 putative active site [active] 911045002933 substrate binding site [chemical binding]; other site 911045002934 putative cosubstrate binding site; other site 911045002935 catalytic site [active] 911045002936 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 911045002937 substrate binding site [chemical binding]; other site 911045002938 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 911045002939 active site 911045002940 catalytic residues [active] 911045002941 metal binding site [ion binding]; metal-binding site 911045002942 RmuC family; Region: RmuC; pfam02646 911045002943 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045002944 Helix-turn-helix domains; Region: HTH; cl00088 911045002945 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045002946 dimerization interface [polypeptide binding]; other site 911045002947 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 911045002948 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045002949 putative metal binding site [ion binding]; other site 911045002950 Predicted amidohydrolase [General function prediction only]; Region: COG0388 911045002951 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 911045002952 putative active site [active] 911045002953 catalytic triad [active] 911045002954 putative dimer interface [polypeptide binding]; other site 911045002955 Predicted amidohydrolase [General function prediction only]; Region: COG0388 911045002956 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 911045002957 putative active site [active] 911045002958 catalytic triad [active] 911045002959 putative dimer interface [polypeptide binding]; other site 911045002960 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 911045002961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002962 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 911045002963 SAF domain; Region: SAF; cl00555 911045002964 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 911045002965 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 911045002966 BON domain; Region: BON; cl02771 911045002967 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 911045002968 Type IV pili component [Cell motility and secretion]; Region: COG5461; cl02279 911045002969 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 911045002970 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 911045002971 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 911045002972 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 911045002973 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 911045002974 ATP binding site [chemical binding]; other site 911045002975 Walker A motif; other site 911045002976 hexamer interface [polypeptide binding]; other site 911045002977 Walker B motif; other site 911045002978 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 911045002979 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 911045002980 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 911045002981 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 911045002982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045002983 TPR motif; other site 911045002984 binding surface 911045002985 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 911045002986 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 911045002987 interface (dimer of trimers) [polypeptide binding]; other site 911045002988 Substrate-binding/catalytic site; other site 911045002989 Zn-binding sites [ion binding]; other site 911045002990 NlpC/P60 family; Region: NLPC_P60; cl11438 911045002991 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 911045002992 TadE-like protein; Region: TadE; cl10688 911045002993 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 911045002994 TadE-like protein; Region: TadE; cl10688 911045002995 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 911045002996 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 911045002997 dimer interaction site [polypeptide binding]; other site 911045002998 substrate-binding tunnel; other site 911045002999 active site 911045003000 catalytic site [active] 911045003001 substrate binding site [chemical binding]; other site 911045003002 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 911045003003 propionate/acetate kinase; Provisional; Region: PRK12379 911045003004 Acetokinase family; Region: Acetate_kinase; cl01029 911045003005 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 911045003006 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 911045003007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045003008 motif II; other site 911045003009 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 911045003010 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 911045003011 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 911045003012 trimer interface [polypeptide binding]; other site 911045003013 active site 911045003014 substrate binding site [chemical binding]; other site 911045003015 CoA binding site [chemical binding]; other site 911045003016 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045003017 Helix-turn-helix domains; Region: HTH; cl00088 911045003018 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 911045003019 dimerization interface [polypeptide binding]; other site 911045003020 substrate binding pocket [chemical binding]; other site 911045003021 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045003022 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 911045003023 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 911045003024 homohexameric interface [polypeptide binding]; other site 911045003025 nucleotide binding site [chemical binding]; other site 911045003026 N-acetyl-L-glutamate binding site [chemical binding]; other site 911045003027 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045003028 Predicted GTPase [General function prediction only]; Region: COG0218 911045003029 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 911045003030 G1 box; other site 911045003031 GTP/Mg2+ binding site [chemical binding]; other site 911045003032 Switch I region; other site 911045003033 G2 box; other site 911045003034 G3 box; other site 911045003035 Switch II region; other site 911045003036 G4 box; other site 911045003037 G5 box; other site 911045003038 membrane protein insertase; Provisional; Region: PRK01318 911045003039 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 911045003040 Ribonuclease P; Region: Ribonuclease_P; cl00457 911045003041 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 911045003042 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 911045003043 mercuric reductase; Validated; Region: PRK06370 911045003044 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 911045003045 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 911045003046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045003047 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045003048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 911045003049 dimer interface [polypeptide binding]; other site 911045003050 phosphorylation site [posttranslational modification] 911045003051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045003052 ATP binding site [chemical binding]; other site 911045003053 Mg2+ binding site [ion binding]; other site 911045003054 G-X-G motif; other site 911045003055 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 911045003056 active site 911045003057 dimer interface [polypeptide binding]; other site 911045003058 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 911045003059 putative FMN binding site [chemical binding]; other site 911045003060 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 911045003061 MPT binding site; other site 911045003062 trimer interface [polypeptide binding]; other site 911045003063 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 911045003064 iron-sulfur cluster [ion binding]; other site 911045003065 [2Fe-2S] cluster binding site [ion binding]; other site 911045003066 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 911045003067 active site 911045003068 FMN binding site [chemical binding]; other site 911045003069 substrate binding site [chemical binding]; other site 911045003070 3Fe-4S cluster binding site [ion binding]; other site 911045003071 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 911045003072 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 911045003073 iron-sulfur cluster [ion binding]; other site 911045003074 [2Fe-2S] cluster binding site [ion binding]; other site 911045003075 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045003076 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 911045003077 C-terminal domain interface [polypeptide binding]; other site 911045003078 GSH binding site (G-site) [chemical binding]; other site 911045003079 dimer interface [polypeptide binding]; other site 911045003080 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 911045003081 N-terminal domain interface [polypeptide binding]; other site 911045003082 dimer interface [polypeptide binding]; other site 911045003083 substrate binding pocket (H-site) [chemical binding]; other site 911045003084 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045003085 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045003086 substrate binding pocket [chemical binding]; other site 911045003087 membrane-bound complex binding site; other site 911045003088 hinge residues; other site 911045003089 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 911045003090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003091 dimer interface [polypeptide binding]; other site 911045003092 conserved gate region; other site 911045003093 putative PBP binding loops; other site 911045003094 ABC-ATPase subunit interface; other site 911045003095 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 911045003096 nudix motif; other site 911045003097 kynureninase; Region: kynureninase; TIGR01814 911045003098 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045003099 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045003100 catalytic residue [active] 911045003101 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045003102 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 911045003103 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 911045003104 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 911045003105 Walker A/P-loop; other site 911045003106 ATP binding site [chemical binding]; other site 911045003107 Q-loop/lid; other site 911045003108 ABC transporter signature motif; other site 911045003109 Walker B; other site 911045003110 D-loop; other site 911045003111 H-loop/switch region; other site 911045003112 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045003113 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 911045003114 Walker A/P-loop; other site 911045003115 ATP binding site [chemical binding]; other site 911045003116 Q-loop/lid; other site 911045003117 ABC transporter signature motif; other site 911045003118 Walker B; other site 911045003119 D-loop; other site 911045003120 H-loop/switch region; other site 911045003121 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045003122 TM-ABC transporter signature motif; other site 911045003123 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045003124 TM-ABC transporter signature motif; other site 911045003125 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 911045003126 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 911045003127 putative ligand binding site [chemical binding]; other site 911045003128 Hemin uptake protein hemP; Region: hemP; cl10043 911045003129 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 911045003130 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 911045003131 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 911045003132 Gram-negative bacterial tonB protein; Region: TonB; cl10048 911045003133 Helix-turn-helix domains; Region: HTH; cl00088 911045003134 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045003135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045003136 DNA-binding site [nucleotide binding]; DNA binding site 911045003137 FCD domain; Region: FCD; cl11656 911045003138 BCCT family transporter; Region: BCCT; cl00569 911045003139 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 911045003140 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 911045003141 active site pocket [active] 911045003142 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 911045003143 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 911045003144 galactarate dehydratase; Region: galactar-dH20; TIGR03248 911045003145 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045003146 EamA-like transporter family; Region: EamA; cl01037 911045003147 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 911045003148 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045003149 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 911045003150 putative dimer interface [polypeptide binding]; other site 911045003151 N-terminal domain interface [polypeptide binding]; other site 911045003152 putative substrate binding pocket (H-site) [chemical binding]; other site 911045003153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045003154 Helix-turn-helix domains; Region: HTH; cl00088 911045003155 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 911045003156 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045003157 N-terminal plug; other site 911045003158 ligand-binding site [chemical binding]; other site 911045003159 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 911045003160 siderophore binding site; other site 911045003161 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045003162 ABC-ATPase subunit interface; other site 911045003163 dimer interface [polypeptide binding]; other site 911045003164 putative PBP binding regions; other site 911045003165 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 911045003166 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045003167 ABC-ATPase subunit interface; other site 911045003168 dimer interface [polypeptide binding]; other site 911045003169 putative PBP binding regions; other site 911045003170 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 911045003171 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 911045003172 Walker A/P-loop; other site 911045003173 ATP binding site [chemical binding]; other site 911045003174 Q-loop/lid; other site 911045003175 ABC transporter signature motif; other site 911045003176 Walker B; other site 911045003177 D-loop; other site 911045003178 H-loop/switch region; other site 911045003179 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 911045003180 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 911045003181 FAD binding pocket [chemical binding]; other site 911045003182 FAD binding motif [chemical binding]; other site 911045003183 phosphate binding motif [ion binding]; other site 911045003184 NAD binding pocket [chemical binding]; other site 911045003185 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 911045003186 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 911045003187 G1 box; other site 911045003188 GTP/Mg2+ binding site [chemical binding]; other site 911045003189 Switch I region; other site 911045003190 G2 box; other site 911045003191 G3 box; other site 911045003192 Switch II region; other site 911045003193 G4 box; other site 911045003194 G5 box; other site 911045003195 Nucleoside recognition; Region: Gate; cl00486 911045003196 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 911045003197 Nucleoside recognition; Region: Gate; cl00486 911045003198 FeoA domain; Region: FeoA; cl00838 911045003199 muropeptide transporter; Validated; Region: ampG; PRK11010 911045003200 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 911045003201 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 911045003202 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045003203 N-terminal plug; other site 911045003204 ligand-binding site [chemical binding]; other site 911045003205 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 911045003206 Carbon starvation protein CstA; Region: CstA; pfam02554 911045003207 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 911045003208 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 911045003209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045003210 active site 911045003211 phosphorylation site [posttranslational modification] 911045003212 intermolecular recognition site; other site 911045003213 dimerization interface [polypeptide binding]; other site 911045003214 LytTr DNA-binding domain; Region: LytTR; cl04498 911045003215 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 911045003216 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 911045003217 Histidine kinase; Region: His_kinase; pfam06580 911045003218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 911045003219 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045003220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045003221 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 911045003222 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 911045003223 metal-binding site 911045003224 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045003225 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 911045003226 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 911045003227 putative metal binding site; other site 911045003228 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 911045003229 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 911045003230 transcriptional activator RfaH; Region: RfaH; TIGR01955 911045003231 Bacterial sugar transferase; Region: Bac_transf; cl00939 911045003232 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 911045003233 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 911045003234 Chain length determinant protein; Region: Wzz; cl15801 911045003235 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045003236 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 911045003237 active site 911045003238 metal binding site [ion binding]; metal-binding site 911045003239 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 911045003240 O-Antigen ligase; Region: Wzy_C; cl04850 911045003241 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 911045003242 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 911045003243 SLBB domain; Region: SLBB; pfam10531 911045003244 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 911045003245 active site 911045003246 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045003247 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045003248 Helix-turn-helix domains; Region: HTH; cl00088 911045003249 Helix-turn-helix domains; Region: HTH; cl00088 911045003250 Winged helix-turn helix; Region: HTH_29; pfam13551 911045003251 Helix-turn-helix domains; Region: HTH; cl00088 911045003252 Integrase core domain; Region: rve; cl01316 911045003253 Integrase core domain; Region: rve_3; cl15866 911045003254 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 911045003255 homotrimer interaction site [polypeptide binding]; other site 911045003256 putative active site [active] 911045003257 Protein of unknown function (DUF3726); Region: DUF3726; pfam12525 911045003258 BCCT family transporter; Region: BCCT; cl00569 911045003259 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045003260 active site 911045003261 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 911045003262 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045003263 NAD(P) binding site [chemical binding]; other site 911045003264 catalytic residues [active] 911045003265 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045003266 Helix-turn-helix domains; Region: HTH; cl00088 911045003267 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 911045003268 putative dimerization interface [polypeptide binding]; other site 911045003269 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 911045003270 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 911045003271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045003272 catalytic residue [active] 911045003273 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045003274 homotrimer interaction site [polypeptide binding]; other site 911045003275 putative active site [active] 911045003276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 911045003277 YheO-like PAS domain; Region: PAS_6; pfam08348 911045003278 Helix-turn-helix domains; Region: HTH; cl00088 911045003279 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 911045003280 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045003281 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 911045003282 active site 911045003283 BCCT family transporter; Region: BCCT; cl00569 911045003284 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 911045003285 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 911045003286 metal binding site [ion binding]; metal-binding site 911045003287 putative dimer interface [polypeptide binding]; other site 911045003288 RHS Repeat; Region: RHS_repeat; cl11982 911045003289 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 911045003290 RHS Repeat; Region: RHS_repeat; cl11982 911045003291 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 911045003292 Protein of unknown function (DUF796); Region: DUF796; cl01226 911045003293 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 911045003294 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 911045003295 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 911045003296 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 911045003297 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045003298 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045003299 ligand binding site [chemical binding]; other site 911045003300 flexible hinge region; other site 911045003301 Helix-turn-helix domains; Region: HTH; cl00088 911045003302 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 911045003303 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045003304 Helix-turn-helix domains; Region: HTH; cl00088 911045003305 Winged helix-turn helix; Region: HTH_29; pfam13551 911045003306 Helix-turn-helix domains; Region: HTH; cl00088 911045003307 Integrase core domain; Region: rve; cl01316 911045003308 Integrase core domain; Region: rve_3; cl15866 911045003309 Helix-turn-helix domains; Region: HTH; cl00088 911045003310 HI0933-like protein; Region: HI0933_like; pfam03486 911045003311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045003312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045003313 Nitrate and nitrite sensing; Region: NIT; pfam08376 911045003314 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 911045003315 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045003316 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045003317 dimer interface [polypeptide binding]; other site 911045003318 putative CheW interface [polypeptide binding]; other site 911045003319 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045003320 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045003321 Helix-turn-helix domains; Region: HTH; cl00088 911045003322 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 911045003323 DNA-binding site [nucleotide binding]; DNA binding site 911045003324 RNA-binding motif; other site 911045003325 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045003326 TM-ABC transporter signature motif; other site 911045003327 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045003328 TM-ABC transporter signature motif; other site 911045003329 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045003330 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 911045003331 Walker A/P-loop; other site 911045003332 ATP binding site [chemical binding]; other site 911045003333 Q-loop/lid; other site 911045003334 ABC transporter signature motif; other site 911045003335 Walker B; other site 911045003336 D-loop; other site 911045003337 H-loop/switch region; other site 911045003338 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 911045003339 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 911045003340 Walker A/P-loop; other site 911045003341 ATP binding site [chemical binding]; other site 911045003342 Q-loop/lid; other site 911045003343 ABC transporter signature motif; other site 911045003344 Walker B; other site 911045003345 D-loop; other site 911045003346 H-loop/switch region; other site 911045003347 bile acid transporter; Region: bass; TIGR00841 911045003348 Membrane transport protein; Region: Mem_trans; cl09117 911045003349 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 911045003350 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 911045003351 putative ligand binding site [chemical binding]; other site 911045003352 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 911045003353 active site residue [active] 911045003354 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 911045003355 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 911045003356 conserved cys residue [active] 911045003357 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045003358 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045003359 HI0933-like protein; Region: HI0933_like; pfam03486 911045003360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045003361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045003362 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 911045003363 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 911045003364 putative dimer interface [polypeptide binding]; other site 911045003365 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045003366 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045003367 active site 911045003368 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 911045003369 putative metal binding site; other site 911045003370 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 911045003371 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 911045003372 active site 911045003373 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 911045003374 homotrimer interaction site [polypeptide binding]; other site 911045003375 putative active site [active] 911045003376 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045003377 Helix-turn-helix domains; Region: HTH; cl00088 911045003378 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 911045003379 dimerization interface [polypeptide binding]; other site 911045003380 substrate binding pocket [chemical binding]; other site 911045003381 siroheme synthase; Provisional; Region: cysG; PRK10637 911045003382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045003383 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 911045003384 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 911045003385 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 911045003386 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 911045003387 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 911045003388 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 911045003389 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 911045003390 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 911045003391 Active Sites [active] 911045003392 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 911045003393 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 911045003394 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045003395 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045003396 Walker A/P-loop; other site 911045003397 ATP binding site [chemical binding]; other site 911045003398 Q-loop/lid; other site 911045003399 ABC transporter signature motif; other site 911045003400 Walker B; other site 911045003401 D-loop; other site 911045003402 H-loop/switch region; other site 911045003403 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045003404 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 911045003405 NAD(P) binding site [chemical binding]; other site 911045003406 catalytic residues [active] 911045003407 catalytic residues [active] 911045003408 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 911045003409 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 911045003410 putative NAD(P) binding site [chemical binding]; other site 911045003411 active site 911045003412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045003413 active site 911045003414 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 911045003415 phosphorylation site [posttranslational modification] 911045003416 intermolecular recognition site; other site 911045003417 dimerization interface [polypeptide binding]; other site 911045003418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045003419 active site 911045003420 phosphorylation site [posttranslational modification] 911045003421 intermolecular recognition site; other site 911045003422 dimerization interface [polypeptide binding]; other site 911045003423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045003424 metal binding site [ion binding]; metal-binding site 911045003425 active site 911045003426 I-site; other site 911045003427 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 911045003428 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 911045003429 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 911045003430 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045003431 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 911045003432 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 911045003433 Walker A/P-loop; other site 911045003434 ATP binding site [chemical binding]; other site 911045003435 Q-loop/lid; other site 911045003436 ABC transporter signature motif; other site 911045003437 Walker B; other site 911045003438 D-loop; other site 911045003439 H-loop/switch region; other site 911045003440 TOBE domain; Region: TOBE_2; cl01440 911045003441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003442 dimer interface [polypeptide binding]; other site 911045003443 conserved gate region; other site 911045003444 putative PBP binding loops; other site 911045003445 ABC-ATPase subunit interface; other site 911045003446 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045003447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003448 dimer interface [polypeptide binding]; other site 911045003449 conserved gate region; other site 911045003450 putative PBP binding loops; other site 911045003451 ABC-ATPase subunit interface; other site 911045003452 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045003453 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045003454 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045003455 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045003456 homotrimer interaction site [polypeptide binding]; other site 911045003457 putative active site [active] 911045003458 LysE type translocator; Region: LysE; cl00565 911045003459 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 911045003460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003461 dimer interface [polypeptide binding]; other site 911045003462 conserved gate region; other site 911045003463 putative PBP binding loops; other site 911045003464 ABC-ATPase subunit interface; other site 911045003465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045003466 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 911045003467 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045003468 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 911045003469 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 911045003470 tetramer interface [polypeptide binding]; other site 911045003471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045003472 catalytic residue [active] 911045003473 PAS domain; Region: PAS_9; pfam13426 911045003474 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 911045003475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045003476 putative active site [active] 911045003477 heme pocket [chemical binding]; other site 911045003478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045003479 dimer interface [polypeptide binding]; other site 911045003480 phosphorylation site [posttranslational modification] 911045003481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045003482 ATP binding site [chemical binding]; other site 911045003483 Mg2+ binding site [ion binding]; other site 911045003484 G-X-G motif; other site 911045003485 Phasin protein; Region: Phasin_2; cl11491 911045003486 Phasin protein; Region: Phasin_2; cl11491 911045003487 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045003488 Carboxylesterase family; Region: COesterase; pfam00135 911045003489 substrate binding pocket [chemical binding]; other site 911045003490 catalytic triad [active] 911045003491 putative outer membrane lipoprotein; Provisional; Region: PRK10510 911045003492 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 911045003493 ligand binding site [chemical binding]; other site 911045003494 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 911045003495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045003496 S-adenosylmethionine binding site [chemical binding]; other site 911045003497 H+ Antiporter protein; Region: 2A0121; TIGR00900 911045003498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045003499 putative substrate translocation pore; other site 911045003500 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 911045003501 putative homotetramer interface [polypeptide binding]; other site 911045003502 putative homodimer interface [polypeptide binding]; other site 911045003503 putative metal binding site [ion binding]; other site 911045003504 putative homodimer-homodimer interface [polypeptide binding]; other site 911045003505 putative allosteric switch controlling residues; other site 911045003506 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 911045003507 active site 911045003508 LysE type translocator; Region: LysE; cl00565 911045003509 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 911045003510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045003511 DNA-binding site [nucleotide binding]; DNA binding site 911045003512 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045003513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045003514 homodimer interface [polypeptide binding]; other site 911045003515 catalytic residue [active] 911045003516 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 911045003517 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 911045003518 ligand binding site [chemical binding]; other site 911045003519 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 911045003520 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cd00159 911045003521 GTPase interaction site; other site 911045003522 catalytic residue [active] 911045003523 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045003524 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045003525 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 911045003526 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 911045003527 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 911045003528 homodimer interface [polypeptide binding]; other site 911045003529 NADP binding site [chemical binding]; other site 911045003530 substrate binding site [chemical binding]; other site 911045003531 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 911045003532 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 911045003533 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 911045003534 putative active site [active] 911045003535 putative substrate binding site [chemical binding]; other site 911045003536 putative cosubstrate binding site; other site 911045003537 catalytic site [active] 911045003538 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 911045003539 putative ADP-binding pocket [chemical binding]; other site 911045003540 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 911045003541 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045003542 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045003543 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045003544 multidrug efflux protein; Reviewed; Region: PRK09579 911045003545 multidrug efflux protein; Reviewed; Region: PRK09579 911045003546 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 911045003547 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 911045003548 FAD binding domain; Region: FAD_binding_4; pfam01565 911045003549 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 911045003550 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 911045003551 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 911045003552 AMP-binding enzyme; Region: AMP-binding; cl15778 911045003553 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045003554 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 911045003555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045003556 Coenzyme A binding pocket [chemical binding]; other site 911045003557 Helix-turn-helix domains; Region: HTH; cl00088 911045003558 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 911045003559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045003560 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045003561 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045003562 Cupin domain; Region: Cupin_2; cl09118 911045003563 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 911045003564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045003565 FeS/SAM binding site; other site 911045003566 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045003567 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045003568 Walker A/P-loop; other site 911045003569 ATP binding site [chemical binding]; other site 911045003570 Q-loop/lid; other site 911045003571 ABC transporter signature motif; other site 911045003572 Walker B; other site 911045003573 D-loop; other site 911045003574 H-loop/switch region; other site 911045003575 Transcriptional regulator [Transcription]; Region: IclR; COG1414 911045003576 Bacterial transcriptional regulator; Region: IclR; pfam01614 911045003577 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045003578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045003579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003580 dimer interface [polypeptide binding]; other site 911045003581 conserved gate region; other site 911045003582 putative PBP binding loops; other site 911045003583 ABC-ATPase subunit interface; other site 911045003584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003585 dimer interface [polypeptide binding]; other site 911045003586 conserved gate region; other site 911045003587 putative PBP binding loops; other site 911045003588 ABC-ATPase subunit interface; other site 911045003589 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 911045003590 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 911045003591 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 911045003592 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 911045003593 active site 911045003594 intersubunit interface [polypeptide binding]; other site 911045003595 catalytic residue [active] 911045003596 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 911045003597 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 911045003598 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 911045003599 Dehydratase family; Region: ILVD_EDD; cl00340 911045003600 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 911045003601 Proline dehydrogenase; Region: Pro_dh; cl03282 911045003602 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 911045003603 Glutamate binding site [chemical binding]; other site 911045003604 NAD binding site [chemical binding]; other site 911045003605 catalytic residues [active] 911045003606 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 911045003607 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045003608 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045003609 putative DNA binding site [nucleotide binding]; other site 911045003610 putative Zn2+ binding site [ion binding]; other site 911045003611 Helix-turn-helix domains; Region: HTH; cl00088 911045003612 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045003613 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 911045003614 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 911045003615 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 911045003616 putative substrate binding site [chemical binding]; other site 911045003617 nucleotide binding site [chemical binding]; other site 911045003618 nucleotide binding site [chemical binding]; other site 911045003619 homodimer interface [polypeptide binding]; other site 911045003620 ornithine carbamoyltransferase; Validated; Region: PRK02102 911045003621 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 911045003622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045003623 Amidinotransferase; Region: Amidinotransf; cl12043 911045003624 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045003625 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 911045003626 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 911045003627 phosphate binding site [ion binding]; other site 911045003628 putative substrate binding pocket [chemical binding]; other site 911045003629 dimer interface [polypeptide binding]; other site 911045003630 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 911045003631 AMP-binding enzyme; Region: AMP-binding; cl15778 911045003632 Glucuronate isomerase; Region: UxaC; cl00829 911045003633 D-mannonate oxidoreductase; Provisional; Region: PRK15037 911045003634 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 911045003635 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 911045003636 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 911045003637 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 911045003638 putative active site [active] 911045003639 putative catalytic site [active] 911045003640 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045003641 DctM-like transporters; Region: DctM; pfam06808 911045003642 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045003643 beta-D-glucuronidase; Provisional; Region: PRK10150 911045003644 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 911045003645 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 911045003646 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 911045003647 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 911045003648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045003649 DNA-binding site [nucleotide binding]; DNA binding site 911045003650 FCD domain; Region: FCD; cl11656 911045003651 mannonate dehydratase; Provisional; Region: PRK03906 911045003652 mannonate dehydratase; Region: uxuA; TIGR00695 911045003653 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 911045003654 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 911045003655 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045003656 ABC-ATPase subunit interface; other site 911045003657 dimer interface [polypeptide binding]; other site 911045003658 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 911045003659 metal binding site 2 [ion binding]; metal-binding site 911045003660 putative DNA binding helix; other site 911045003661 metal binding site 1 [ion binding]; metal-binding site 911045003662 dimer interface [polypeptide binding]; other site 911045003663 structural Zn2+ binding site [ion binding]; other site 911045003664 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 911045003665 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045003666 DNA binding residues [nucleotide binding] 911045003667 dimerization interface [polypeptide binding]; other site 911045003668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045003669 Helix-turn-helix domains; Region: HTH; cl00088 911045003670 SCP-2 sterol transfer family; Region: SCP2; cl01225 911045003671 Cupin domain; Region: Cupin_2; cl09118 911045003672 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 911045003673 active site 911045003674 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 911045003675 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 911045003676 putative catalytic cysteine [active] 911045003677 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 911045003678 putative active site [active] 911045003679 metal binding site [ion binding]; metal-binding site 911045003680 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 911045003681 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 911045003682 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 911045003683 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 911045003684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045003685 DNA-binding site [nucleotide binding]; DNA binding site 911045003686 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045003687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045003688 homodimer interface [polypeptide binding]; other site 911045003689 catalytic residue [active] 911045003690 EamA-like transporter family; Region: EamA; cl01037 911045003691 Predicted deacylase [General function prediction only]; Region: COG3608 911045003692 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 911045003693 putative active site [active] 911045003694 Zn binding site [ion binding]; other site 911045003695 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 911045003696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045003697 S-adenosylmethionine binding site [chemical binding]; other site 911045003698 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 911045003699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045003700 Helix-turn-helix domains; Region: HTH; cl00088 911045003701 Protein of unknown function (DUF418); Region: DUF418; cl12135 911045003702 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 911045003703 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045003704 motif II; other site 911045003705 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 911045003706 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 911045003707 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 911045003708 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 911045003709 GIY-YIG motif/motif A; other site 911045003710 putative active site [active] 911045003711 putative metal binding site [ion binding]; other site 911045003712 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 911045003713 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 911045003714 ATP binding site [chemical binding]; other site 911045003715 Mg++ binding site [ion binding]; other site 911045003716 motif III; other site 911045003717 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045003718 nucleotide binding region [chemical binding]; other site 911045003719 ATP-binding site [chemical binding]; other site 911045003720 Cupin domain; Region: Cupin_2; cl09118 911045003721 MgtE intracellular N domain; Region: MgtE_N; cl15244 911045003722 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 911045003723 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 911045003724 Divalent cation transporter; Region: MgtE; cl00786 911045003725 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045003726 BCCT family transporter; Region: BCCT; cl00569 911045003727 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 911045003728 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045003729 active site 911045003730 catalytic tetrad [active] 911045003731 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045003732 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 911045003733 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 911045003734 Cytochrome c; Region: Cytochrom_C; cl11414 911045003735 Cytochrome c; Region: Cytochrom_C; cl11414 911045003736 Cytochrome c; Region: Cytochrom_C; cl11414 911045003737 Cytochrome c; Region: Cytochrom_C; cl11414 911045003738 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 911045003739 Moco binding site; other site 911045003740 metal coordination site [ion binding]; other site 911045003741 dimerization interface [polypeptide binding]; other site 911045003742 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 911045003743 active site 911045003744 metal binding site [ion binding]; metal-binding site 911045003745 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045003746 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 911045003747 Cytochrome c [Energy production and conversion]; Region: COG3258 911045003748 Cytochrome c [Energy production and conversion]; Region: COG3258 911045003749 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 911045003750 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 911045003751 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 911045003752 Cytochrome c; Region: Cytochrom_C; cl11414 911045003753 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 911045003754 catalytic residues [active] 911045003755 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 911045003756 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045003757 Domain of unknown function (DUF336); Region: DUF336; cl01249 911045003758 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045003759 dimerization interface [polypeptide binding]; other site 911045003760 putative DNA binding site [nucleotide binding]; other site 911045003761 putative Zn2+ binding site [ion binding]; other site 911045003762 Sulphur transport; Region: Sulf_transp; cl01018 911045003763 Sulphur transport; Region: Sulf_transp; cl01018 911045003764 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 911045003765 Isochorismatase family; Region: Isochorismatase; pfam00857 911045003766 catalytic triad [active] 911045003767 metal binding site [ion binding]; metal-binding site 911045003768 conserved cis-peptide bond; other site 911045003769 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 911045003770 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 911045003771 active site 911045003772 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 911045003773 FAD binding domain; Region: FAD_binding_4; pfam01565 911045003774 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 911045003775 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 911045003776 uncharacterized ygcE-like proteins, N-terminal domain; Region: FGGY_ygcE_like; cd07779 911045003777 putative N- and C-terminal domain interface [polypeptide binding]; other site 911045003778 putative active site [active] 911045003779 putative MgATP binding site [chemical binding]; other site 911045003780 catalytic site [active] 911045003781 metal binding site [ion binding]; metal-binding site 911045003782 putative carbohydrate binding site [chemical binding]; other site 911045003783 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 911045003784 Transcriptional activator [Transcription]; Region: ChrR; COG3806 911045003785 Cupin domain; Region: Cupin_2; cl09118 911045003786 Cupin domain; Region: Cupin_2; cl09118 911045003787 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 911045003788 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 911045003789 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 911045003790 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045003791 LysE type translocator; Region: LysE; cl00565 911045003792 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045003793 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 911045003794 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 911045003795 active site 911045003796 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 911045003797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045003798 DNA-binding site [nucleotide binding]; DNA binding site 911045003799 UTRA domain; Region: UTRA; cl01230 911045003800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003801 dimer interface [polypeptide binding]; other site 911045003802 conserved gate region; other site 911045003803 putative PBP binding loops; other site 911045003804 ABC-ATPase subunit interface; other site 911045003805 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045003806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003807 dimer interface [polypeptide binding]; other site 911045003808 conserved gate region; other site 911045003809 putative PBP binding loops; other site 911045003810 ABC-ATPase subunit interface; other site 911045003811 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045003812 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 911045003813 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045003814 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045003815 Walker A/P-loop; other site 911045003816 ATP binding site [chemical binding]; other site 911045003817 Q-loop/lid; other site 911045003818 ABC transporter signature motif; other site 911045003819 Walker B; other site 911045003820 D-loop; other site 911045003821 H-loop/switch region; other site 911045003822 TOBE domain; Region: TOBE_2; cl01440 911045003823 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045003824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045003825 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 911045003826 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 911045003827 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 911045003828 dimer interface [polypeptide binding]; other site 911045003829 active site 911045003830 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 911045003831 dimer interface [polypeptide binding]; other site 911045003832 active site 911045003833 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 911045003834 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 911045003835 dimer interface [polypeptide binding]; other site 911045003836 active site 911045003837 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 911045003838 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 911045003839 fructokinase; Reviewed; Region: PRK09557 911045003840 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 911045003841 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 911045003842 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045003843 active site 911045003844 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045003845 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045003846 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045003847 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 911045003848 putative active site [active] 911045003849 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 911045003850 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045003851 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 911045003852 Walker A/P-loop; other site 911045003853 ATP binding site [chemical binding]; other site 911045003854 Q-loop/lid; other site 911045003855 ABC transporter signature motif; other site 911045003856 Walker B; other site 911045003857 D-loop; other site 911045003858 H-loop/switch region; other site 911045003859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045003860 Helix-turn-helix domains; Region: HTH; cl00088 911045003861 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045003862 dimerization interface [polypeptide binding]; other site 911045003863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045003864 NAD(P) binding site [chemical binding]; other site 911045003865 active site 911045003866 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 911045003867 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 911045003868 catalytic triad [active] 911045003869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045003870 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045003871 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 911045003872 classical (c) SDRs; Region: SDR_c; cd05233 911045003873 NAD(P) binding site [chemical binding]; other site 911045003874 active site 911045003875 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 911045003876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045003877 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 911045003878 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045003879 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045003880 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 911045003881 oligomerization interface [polypeptide binding]; other site 911045003882 active site 911045003883 metal binding site [ion binding]; metal-binding site 911045003884 Isochorismatase family; Region: Isochorismatase; pfam00857 911045003885 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 911045003886 catalytic triad [active] 911045003887 conserved cis-peptide bond; other site 911045003888 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 911045003889 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045003890 active site 911045003891 metal binding site [ion binding]; metal-binding site 911045003892 hexamer interface [polypeptide binding]; other site 911045003893 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 911045003894 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 911045003895 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 911045003896 Protein of unknown function (DUF805); Region: DUF805; cl01224 911045003897 Protein of unknown function (DUF805); Region: DUF805; cl01224 911045003898 Helix-turn-helix domains; Region: HTH; cl00088 911045003899 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 911045003900 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045003901 G1 box; other site 911045003902 GTP/Mg2+ binding site [chemical binding]; other site 911045003903 G2 box; other site 911045003904 Switch I region; other site 911045003905 G3 box; other site 911045003906 Switch II region; other site 911045003907 G4 box; other site 911045003908 Nucleoside recognition; Region: Gate; cl00486 911045003909 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 911045003910 Nucleoside recognition; Region: Gate; cl00486 911045003911 FeoA domain; Region: FeoA; cl00838 911045003912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 911045003913 Predicted kinase [General function prediction only]; Region: COG0645 911045003914 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045003915 active site 911045003916 thiamine pyrophosphate protein; Validated; Region: PRK08199 911045003917 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045003918 PYR/PP interface [polypeptide binding]; other site 911045003919 dimer interface [polypeptide binding]; other site 911045003920 TPP binding site [chemical binding]; other site 911045003921 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 911045003922 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 911045003923 TPP-binding site [chemical binding]; other site 911045003924 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 911045003925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045003926 CoA-ligase; Region: Ligase_CoA; cl02894 911045003927 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045003928 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045003929 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 911045003930 Ligand Binding Site [chemical binding]; other site 911045003931 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045003932 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045003933 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045003934 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045003935 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045003936 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 911045003937 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 911045003938 generic binding surface II; other site 911045003939 generic binding surface I; other site 911045003940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 911045003941 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 911045003942 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 911045003943 cyclase homology domain; Region: CHD; cd07302 911045003944 nucleotidyl binding site; other site 911045003945 metal binding site [ion binding]; metal-binding site 911045003946 dimer interface [polypeptide binding]; other site 911045003947 conjugal transfer protein TraD; Provisional; Region: PRK13700 911045003948 Helix-turn-helix domains; Region: HTH; cl00088 911045003949 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045003950 dimerization interface [polypeptide binding]; other site 911045003951 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 911045003952 Helix-turn-helix domains; Region: HTH; cl00088 911045003953 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045003954 dimerization interface [polypeptide binding]; other site 911045003955 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 911045003956 EamA-like transporter family; Region: EamA; cl01037 911045003957 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 911045003958 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 911045003959 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045003960 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045003961 substrate binding pocket [chemical binding]; other site 911045003962 membrane-bound complex binding site; other site 911045003963 hinge residues; other site 911045003964 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 911045003965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003966 dimer interface [polypeptide binding]; other site 911045003967 conserved gate region; other site 911045003968 putative PBP binding loops; other site 911045003969 ABC-ATPase subunit interface; other site 911045003970 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 911045003971 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 911045003972 catalytic triad [active] 911045003973 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 911045003974 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045003975 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045003976 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 911045003977 N-terminal domain interface [polypeptide binding]; other site 911045003978 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045003979 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045003980 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 911045003981 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045003982 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 911045003983 putative C-terminal domain interface [polypeptide binding]; other site 911045003984 putative GSH binding site (G-site) [chemical binding]; other site 911045003985 putative dimer interface [polypeptide binding]; other site 911045003986 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 911045003987 putative N-terminal domain interface [polypeptide binding]; other site 911045003988 putative dimer interface [polypeptide binding]; other site 911045003989 putative substrate binding pocket (H-site) [chemical binding]; other site 911045003990 Helix-turn-helix domains; Region: HTH; cl00088 911045003991 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045003992 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 911045003993 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 911045003994 catalytic residues [active] 911045003995 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045003996 Helix-turn-helix domains; Region: HTH; cl00088 911045003997 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045003998 putative effector binding pocket; other site 911045003999 dimerization interface [polypeptide binding]; other site 911045004000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045004001 Helix-turn-helix domains; Region: HTH; cl00088 911045004002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045004003 dimerization interface [polypeptide binding]; other site 911045004004 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 911045004005 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 911045004006 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 911045004007 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 911045004008 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 911045004009 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 911045004010 active site 911045004011 intersubunit interface [polypeptide binding]; other site 911045004012 zinc binding site [ion binding]; other site 911045004013 Na+ binding site [ion binding]; other site 911045004014 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 911045004015 Cysteine-rich domain; Region: CCG; pfam02754 911045004016 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 911045004017 dimer interface [polypeptide binding]; other site 911045004018 FMN binding site [chemical binding]; other site 911045004019 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045004020 Cytochrome c; Region: Cytochrom_C; cl11414 911045004021 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 911045004022 FAD binding domain; Region: FAD_binding_4; pfam01565 911045004023 FAD binding domain; Region: FAD_binding_4; pfam01565 911045004024 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 911045004025 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 911045004026 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 911045004027 Cysteine-rich domain; Region: CCG; pfam02754 911045004028 Cysteine-rich domain; Region: CCG; pfam02754 911045004029 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 911045004030 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 911045004031 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 911045004032 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045004033 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045004034 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045004035 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 911045004036 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 911045004037 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045004038 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 911045004039 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045004040 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 911045004041 ATP phosphoribosyltransferase; Region: HisG; cl15266 911045004042 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 911045004043 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 911045004044 motif 1; other site 911045004045 dimer interface [polypeptide binding]; other site 911045004046 active site 911045004047 motif 2; other site 911045004048 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 911045004049 active site 911045004050 motif 3; other site 911045004051 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 911045004052 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 911045004053 dimer interface [polypeptide binding]; other site 911045004054 motif 1; other site 911045004055 active site 911045004056 motif 2; other site 911045004057 motif 3; other site 911045004058 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 911045004059 anticodon binding site; other site 911045004060 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 911045004061 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 911045004062 Ligand binding site; other site 911045004063 Putative Catalytic site; other site 911045004064 DXD motif; other site 911045004065 GtrA-like protein; Region: GtrA; cl00971 911045004066 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 911045004067 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 911045004068 YdjC-like protein; Region: YdjC; cl01344 911045004069 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045004070 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045004071 ligand binding site [chemical binding]; other site 911045004072 flexible hinge region; other site 911045004073 Helix-turn-helix domains; Region: HTH; cl00088 911045004074 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 911045004075 heme-binding site [chemical binding]; other site 911045004076 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 911045004077 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 911045004078 heme-binding site [chemical binding]; other site 911045004079 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 911045004080 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 911045004081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045004082 Coenzyme A binding pocket [chemical binding]; other site 911045004083 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 911045004084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045004085 putative substrate translocation pore; other site 911045004086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045004087 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 911045004088 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 911045004089 ring oligomerisation interface [polypeptide binding]; other site 911045004090 ATP/Mg binding site [chemical binding]; other site 911045004091 stacking interactions; other site 911045004092 hinge regions; other site 911045004093 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 911045004094 oligomerisation interface [polypeptide binding]; other site 911045004095 mobile loop; other site 911045004096 roof hairpin; other site 911045004097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045004098 active site 911045004099 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 911045004100 phosphorylation site [posttranslational modification] 911045004101 intermolecular recognition site; other site 911045004102 dimerization interface [polypeptide binding]; other site 911045004103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045004104 Walker A motif; other site 911045004105 ATP binding site [chemical binding]; other site 911045004106 Walker B motif; other site 911045004107 arginine finger; other site 911045004108 Helix-turn-helix domains; Region: HTH; cl00088 911045004109 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045004110 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 911045004111 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 911045004112 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 911045004113 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 911045004114 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 911045004115 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 911045004116 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 911045004117 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 911045004118 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 911045004119 active site 911045004120 HIGH motif; other site 911045004121 nucleotide binding site [chemical binding]; other site 911045004122 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 911045004123 active site 911045004124 KMSKS motif; other site 911045004125 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 911045004126 tRNA binding surface [nucleotide binding]; other site 911045004127 anticodon binding site; other site 911045004128 EamA-like transporter family; Region: EamA; cl01037 911045004129 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045004130 EamA-like transporter family; Region: EamA; cl01037 911045004131 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045004132 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 911045004133 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 911045004134 active site 911045004135 Riboflavin kinase; Region: Flavokinase; cl03312 911045004136 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 911045004137 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 911045004138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045004139 active site 911045004140 phosphorylation site [posttranslational modification] 911045004141 intermolecular recognition site; other site 911045004142 dimerization interface [polypeptide binding]; other site 911045004143 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 911045004144 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 911045004145 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045004146 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045004147 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 911045004148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045004149 ATP binding site [chemical binding]; other site 911045004150 Mg2+ binding site [ion binding]; other site 911045004151 G-X-G motif; other site 911045004152 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 911045004153 ATP binding site [chemical binding]; other site 911045004154 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 911045004155 Porin subfamily; Region: Porin_2; pfam02530 911045004156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004157 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 911045004158 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045004159 RNA binding surface [nucleotide binding]; other site 911045004160 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 911045004161 active site 911045004162 transcription termination factor Rho; Provisional; Region: PRK12678 911045004163 transcription termination factor Rho; Provisional; Region: PRK12678 911045004164 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 911045004165 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 911045004166 nucleoside/Zn binding site; other site 911045004167 dimer interface [polypeptide binding]; other site 911045004168 catalytic motif [active] 911045004169 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045004170 MatE; Region: MatE; cl10513 911045004171 MatE; Region: MatE; cl10513 911045004172 aromatic amino acid exporter; Provisional; Region: PRK11689 911045004173 EamA-like transporter family; Region: EamA; cl01037 911045004174 Cupin domain; Region: Cupin_2; cl09118 911045004175 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045004176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045004177 MarC family integral membrane protein; Region: MarC; cl00919 911045004178 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 911045004179 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 911045004180 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045004181 catalytic residue [active] 911045004182 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045004183 active site 911045004184 metal binding site [ion binding]; metal-binding site 911045004185 Helix-turn-helix domains; Region: HTH; cl00088 911045004186 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045004187 dimerization interface [polypeptide binding]; other site 911045004188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004189 NADH(P)-binding; Region: NAD_binding_10; pfam13460 911045004190 NAD(P) binding site [chemical binding]; other site 911045004191 active site 911045004192 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 911045004193 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 911045004194 putative molybdopterin cofactor binding site [chemical binding]; other site 911045004195 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 911045004196 putative molybdopterin cofactor binding site; other site 911045004197 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 911045004198 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 911045004199 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 911045004200 nucleophile elbow; other site 911045004201 Autoinducer binding domain; Region: Autoind_bind; pfam03472 911045004202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045004203 DNA binding residues [nucleotide binding] 911045004204 dimerization interface [polypeptide binding]; other site 911045004205 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 911045004206 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 911045004207 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045004208 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 911045004209 UbiA prenyltransferase family; Region: UbiA; cl00337 911045004210 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 911045004211 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 911045004212 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 911045004213 active site 911045004214 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 911045004215 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 911045004216 putative acyl-acceptor binding pocket; other site 911045004217 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 911045004218 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 911045004219 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 911045004220 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 911045004221 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 911045004222 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; cl11535 911045004223 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045004224 MatE; Region: MatE; cl10513 911045004225 MatE; Region: MatE; cl10513 911045004226 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 911045004227 DNA binding residues [nucleotide binding] 911045004228 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 911045004229 dimer interface [polypeptide binding]; other site 911045004230 putative metal binding site [ion binding]; other site 911045004231 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 911045004232 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 911045004233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004235 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 911045004236 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 911045004237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004238 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 911045004239 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 911045004240 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 911045004241 LysE type translocator; Region: LysE; cl00565 911045004242 LysE type translocator; Region: LysE; cl00565 911045004243 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 911045004244 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 911045004245 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 911045004246 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 911045004247 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045004248 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 911045004249 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 911045004250 Subunit I/III interface [polypeptide binding]; other site 911045004251 D-pathway; other site 911045004252 Subunit I/VIIc interface [polypeptide binding]; other site 911045004253 Subunit I/IV interface [polypeptide binding]; other site 911045004254 Subunit I/II interface [polypeptide binding]; other site 911045004255 Low-spin heme (heme a) binding site [chemical binding]; other site 911045004256 Subunit I/VIIa interface [polypeptide binding]; other site 911045004257 Subunit I/VIa interface [polypeptide binding]; other site 911045004258 Dimer interface; other site 911045004259 Putative water exit pathway; other site 911045004260 Binuclear center (heme a3/CuB) [ion binding]; other site 911045004261 K-pathway; other site 911045004262 Subunit I/Vb interface [polypeptide binding]; other site 911045004263 Putative proton exit pathway; other site 911045004264 Subunit I/VIb interface; other site 911045004265 Subunit I/VIc interface [polypeptide binding]; other site 911045004266 Electron transfer pathway; other site 911045004267 Subunit I/VIIIb interface [polypeptide binding]; other site 911045004268 Subunit I/VIIb interface [polypeptide binding]; other site 911045004269 UbiA prenyltransferase family; Region: UbiA; cl00337 911045004270 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 911045004271 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 911045004272 Subunit III/VIIa interface [polypeptide binding]; other site 911045004273 Phospholipid binding site [chemical binding]; other site 911045004274 Subunit I/III interface [polypeptide binding]; other site 911045004275 Subunit III/VIb interface [polypeptide binding]; other site 911045004276 Subunit III/VIa interface; other site 911045004277 Subunit III/Vb interface [polypeptide binding]; other site 911045004278 Protein of unknown function (DUF983); Region: DUF983; cl02211 911045004279 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 911045004280 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 911045004281 catalytic triad [active] 911045004282 dimer interface [polypeptide binding]; other site 911045004283 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 911045004284 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 911045004285 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 911045004286 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 911045004287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045004288 catalytic residue [active] 911045004289 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 911045004290 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 911045004291 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 911045004292 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045004293 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 911045004294 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 911045004295 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 911045004296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045004297 PAS fold; Region: PAS_3; pfam08447 911045004298 putative active site [active] 911045004299 heme pocket [chemical binding]; other site 911045004300 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045004301 metal binding site [ion binding]; metal-binding site 911045004302 active site 911045004303 I-site; other site 911045004304 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045004305 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 911045004306 PilZ domain; Region: PilZ; cl01260 911045004307 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 911045004308 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 911045004309 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 911045004310 RNA/DNA hybrid binding site [nucleotide binding]; other site 911045004311 active site 911045004312 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 911045004313 Phosphotransferase enzyme family; Region: APH; pfam01636 911045004314 putative active site [active] 911045004315 putative substrate binding site [chemical binding]; other site 911045004316 ATP binding site [chemical binding]; other site 911045004317 LytB protein; Region: LYTB; cl00507 911045004318 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 911045004319 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 911045004320 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045004321 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 911045004322 lipoyl attachment site [posttranslational modification]; other site 911045004323 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 911045004324 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 911045004325 tetramer interface [polypeptide binding]; other site 911045004326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045004327 catalytic residue [active] 911045004328 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 911045004329 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045004330 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045004331 catalytic residue [active] 911045004332 Protein of unknown function (DUF563); Region: DUF563; cl15705 911045004333 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 911045004334 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 911045004335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045004336 motif II; other site 911045004337 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 911045004338 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 911045004339 active site 911045004340 HIGH motif; other site 911045004341 dimer interface [polypeptide binding]; other site 911045004342 KMSKS motif; other site 911045004343 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045004344 RNA binding surface [nucleotide binding]; other site 911045004345 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 911045004346 active site 911045004347 catalytic motif [active] 911045004348 Zn binding site [ion binding]; other site 911045004349 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 911045004350 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 911045004351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004353 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 911045004354 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 911045004355 putative active site [active] 911045004356 catalytic site [active] 911045004357 putative metal binding site [ion binding]; other site 911045004358 AMP nucleosidase; Provisional; Region: PRK08292 911045004359 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 911045004360 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 911045004361 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 911045004362 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 911045004363 minor groove reading motif; other site 911045004364 helix-hairpin-helix signature motif; other site 911045004365 substrate binding pocket [chemical binding]; other site 911045004366 active site 911045004367 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 911045004368 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 911045004369 DNA binding and oxoG recognition site [nucleotide binding] 911045004370 Protein of unknown function (DUF721); Region: DUF721; cl02324 911045004371 Protease inhibitor Inh; Region: Inh; pfam02974 911045004372 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045004373 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 911045004374 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 911045004375 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 911045004376 Walker A/P-loop; other site 911045004377 ATP binding site [chemical binding]; other site 911045004378 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 911045004379 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 911045004380 ABC transporter signature motif; other site 911045004381 Walker B; other site 911045004382 D-loop; other site 911045004383 H-loop/switch region; other site 911045004384 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 911045004385 ATP synthase A chain; Region: ATP-synt_A; cl00413 911045004386 ATP synthase subunit C; Region: ATP-synt_C; cl00466 911045004387 Plant ATP synthase F0; Region: YMF19; cl07975 911045004388 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 911045004389 Plant ATP synthase F0; Region: YMF19; cl07975 911045004390 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 911045004391 Helix-turn-helix domains; Region: HTH; cl00088 911045004392 WYL domain; Region: WYL; cl14852 911045004393 oxidoreductase; Validated; Region: PRK05717 911045004394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004395 NAD(P) binding site [chemical binding]; other site 911045004396 active site 911045004397 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 911045004398 RNA/DNA hybrid binding site [nucleotide binding]; other site 911045004399 active site 911045004400 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 911045004401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045004402 FeS/SAM binding site; other site 911045004403 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045004404 active site 911045004405 malic enzyme; Reviewed; Region: PRK12862 911045004406 Malic enzyme, N-terminal domain; Region: malic; pfam00390 911045004407 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 911045004408 putative NAD(P) binding site [chemical binding]; other site 911045004409 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 911045004410 Protein of unknown function (DUF962); Region: DUF962; cl01879 911045004411 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045004412 Helix-turn-helix domains; Region: HTH; cl00088 911045004413 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 911045004414 dimerization interface [polypeptide binding]; other site 911045004415 substrate binding pocket [chemical binding]; other site 911045004416 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 911045004417 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 911045004418 Probable beta-xylosidase; Provisional; Region: PLN03080 911045004419 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 911045004420 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 911045004421 Fibronectin type III-like domain; Region: Fn3-like; cl15273 911045004422 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 911045004423 dimer interface [polypeptide binding]; other site 911045004424 motif 1; other site 911045004425 active site 911045004426 motif 2; other site 911045004427 motif 3; other site 911045004428 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 911045004429 tandem repeat interface [polypeptide binding]; other site 911045004430 oligomer interface [polypeptide binding]; other site 911045004431 active site residues [active] 911045004432 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 911045004433 Fe-S cluster binding site [ion binding]; other site 911045004434 active site 911045004435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004436 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 911045004437 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 911045004438 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 911045004439 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 911045004440 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 911045004441 dimerization interface [polypeptide binding]; other site 911045004442 active site 911045004443 L-aspartate oxidase; Provisional; Region: PRK07512 911045004444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004445 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 911045004446 Quinolinate synthetase A protein; Region: NadA; cl00420 911045004447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045004448 putative substrate translocation pore; other site 911045004449 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045004450 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 911045004451 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 911045004452 NADP binding site [chemical binding]; other site 911045004453 dimer interface [polypeptide binding]; other site 911045004454 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 911045004455 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045004456 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 911045004457 active site 911045004458 catalytic residues [active] 911045004459 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 911045004460 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 911045004461 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 911045004462 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 911045004463 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 911045004464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045004465 S-adenosylmethionine binding site [chemical binding]; other site 911045004466 LysE type translocator; Region: LysE; cl00565 911045004467 Protein of unknown function (DUF2385); Region: DUF2385; cl11490 911045004468 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 911045004469 nudix motif; other site 911045004470 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 911045004471 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 911045004472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004473 NAD(P) binding site [chemical binding]; other site 911045004474 active site 911045004475 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 911045004476 FAD binding domain; Region: FAD_binding_4; pfam01565 911045004477 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 911045004478 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 911045004479 NAD binding site [chemical binding]; other site 911045004480 homotetramer interface [polypeptide binding]; other site 911045004481 homodimer interface [polypeptide binding]; other site 911045004482 substrate binding site [chemical binding]; other site 911045004483 active site 911045004484 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045004485 catalytic core [active] 911045004486 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 911045004487 Tetramer interface [polypeptide binding]; other site 911045004488 active site 911045004489 FMN-binding site [chemical binding]; other site 911045004490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 911045004491 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 911045004492 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 911045004493 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 911045004494 dimerization interface [polypeptide binding]; other site 911045004495 active site 911045004496 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 911045004497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045004498 S-adenosylmethionine binding site [chemical binding]; other site 911045004499 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 911045004500 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 911045004501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 911045004502 Cache domain; Region: Cache_1; pfam02743 911045004503 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045004504 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045004505 dimer interface [polypeptide binding]; other site 911045004506 putative CheW interface [polypeptide binding]; other site 911045004507 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 911045004508 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045004509 RNA binding surface [nucleotide binding]; other site 911045004510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 911045004511 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 911045004512 Cu(I) binding site [ion binding]; other site 911045004513 Protein of unknown function (DUF461); Region: DUF461; cl01071 911045004514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045004515 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045004516 putative substrate translocation pore; other site 911045004517 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 911045004518 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 911045004519 TPP-binding site; other site 911045004520 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 911045004521 PYR/PP interface [polypeptide binding]; other site 911045004522 dimer interface [polypeptide binding]; other site 911045004523 TPP binding site [chemical binding]; other site 911045004524 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 911045004525 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 911045004526 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 911045004527 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 911045004528 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 911045004529 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 911045004530 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045004531 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045004532 active site 911045004533 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 911045004534 enoyl-CoA hydratase; Provisional; Region: PRK06688 911045004535 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045004536 substrate binding site [chemical binding]; other site 911045004537 oxyanion hole (OAH) forming residues; other site 911045004538 trimer interface [polypeptide binding]; other site 911045004539 short chain dehydrogenase; Provisional; Region: PRK08278 911045004540 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 911045004541 NAD(P) binding site [chemical binding]; other site 911045004542 homodimer interface [polypeptide binding]; other site 911045004543 active site 911045004544 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 911045004545 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045004546 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045004547 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 911045004548 HSP70 interaction site [polypeptide binding]; other site 911045004549 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 911045004550 substrate binding site [polypeptide binding]; other site 911045004551 dimer interface [polypeptide binding]; other site 911045004552 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 911045004553 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 911045004554 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 911045004555 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 911045004556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045004557 motif II; other site 911045004558 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 911045004559 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 911045004560 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045004561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045004562 homodimer interface [polypeptide binding]; other site 911045004563 catalytic residue [active] 911045004564 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 911045004565 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045004566 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 911045004567 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 911045004568 intersubunit interface [polypeptide binding]; other site 911045004569 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 911045004570 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 911045004571 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045004572 ABC-ATPase subunit interface; other site 911045004573 dimer interface [polypeptide binding]; other site 911045004574 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045004575 ABC-ATPase subunit interface; other site 911045004576 dimer interface [polypeptide binding]; other site 911045004577 putative PBP binding regions; other site 911045004578 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 911045004579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045004580 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045004581 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045004582 Walker A/P-loop; other site 911045004583 ATP binding site [chemical binding]; other site 911045004584 Q-loop/lid; other site 911045004585 ABC transporter signature motif; other site 911045004586 Walker B; other site 911045004587 D-loop; other site 911045004588 H-loop/switch region; other site 911045004589 TOBE domain; Region: TOBE_2; cl01440 911045004590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045004591 dimer interface [polypeptide binding]; other site 911045004592 conserved gate region; other site 911045004593 putative PBP binding loops; other site 911045004594 ABC-ATPase subunit interface; other site 911045004595 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045004596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045004597 dimer interface [polypeptide binding]; other site 911045004598 conserved gate region; other site 911045004599 putative PBP binding loops; other site 911045004600 ABC-ATPase subunit interface; other site 911045004601 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 911045004602 putative hydrophobic ligand binding site [chemical binding]; other site 911045004603 CLM binding site; other site 911045004604 L1 loop; other site 911045004605 DNA binding site [nucleotide binding] 911045004606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045004607 binding surface 911045004608 TPR motif; other site 911045004609 Tetratricopeptide repeat; Region: TPR_16; pfam13432 911045004610 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 911045004611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045004612 dimer interface [polypeptide binding]; other site 911045004613 phosphorylation site [posttranslational modification] 911045004614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045004615 ATP binding site [chemical binding]; other site 911045004616 Mg2+ binding site [ion binding]; other site 911045004617 G-X-G motif; other site 911045004618 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045004619 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 911045004620 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 911045004621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045004622 dimer interface [polypeptide binding]; other site 911045004623 conserved gate region; other site 911045004624 putative PBP binding loops; other site 911045004625 ABC-ATPase subunit interface; other site 911045004626 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 911045004627 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 911045004628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045004629 dimer interface [polypeptide binding]; other site 911045004630 conserved gate region; other site 911045004631 putative PBP binding loops; other site 911045004632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045004633 ABC-ATPase subunit interface; other site 911045004634 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 911045004635 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 911045004636 Walker A/P-loop; other site 911045004637 ATP binding site [chemical binding]; other site 911045004638 Q-loop/lid; other site 911045004639 ABC transporter signature motif; other site 911045004640 Walker B; other site 911045004641 D-loop; other site 911045004642 H-loop/switch region; other site 911045004643 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 911045004644 PhoU domain; Region: PhoU; pfam01895 911045004645 PhoU domain; Region: PhoU; pfam01895 911045004646 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 911045004647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045004648 active site 911045004649 phosphorylation site [posttranslational modification] 911045004650 intermolecular recognition site; other site 911045004651 dimerization interface [polypeptide binding]; other site 911045004652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045004653 DNA binding site [nucleotide binding] 911045004654 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045004655 GcrA cell cycle regulator; Region: GcrA; cl11564 911045004656 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 911045004657 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045004658 inhibitor-cofactor binding pocket; inhibition site 911045004659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045004660 catalytic residue [active] 911045004661 ornithine carbamoyltransferase; Provisional; Region: PRK00779 911045004662 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 911045004663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004664 Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones]; Region: COG1281 911045004665 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 911045004666 dimerization interface [polypeptide binding]; other site 911045004667 domain crossover interface; other site 911045004668 redox-dependent activation switch; other site 911045004669 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 911045004670 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 911045004671 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 911045004672 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 911045004673 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 911045004674 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 911045004675 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045004676 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045004677 substrate binding pocket [chemical binding]; other site 911045004678 membrane-bound complex binding site; other site 911045004679 hinge residues; other site 911045004680 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 911045004681 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 911045004682 DXD motif; other site 911045004683 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 911045004684 Ion transport protein; Region: Ion_trans; pfam00520 911045004685 Ion transport protein; Region: Ion_trans; pfam00520 911045004686 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 911045004687 Protein of unknown function (DUF525); Region: DUF525; cl01119 911045004688 tellurite resistance protein terB; Region: terB; cd07176 911045004689 putative metal binding site [ion binding]; other site 911045004690 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 911045004691 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 911045004692 active site 911045004693 nucleotide binding site [chemical binding]; other site 911045004694 HIGH motif; other site 911045004695 KMSKS motif; other site 911045004696 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 911045004697 Staphylococcal nuclease homologues; Region: SNc; smart00318 911045004698 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 911045004699 Catalytic site; other site 911045004700 Predicted transcriptional regulator [Transcription]; Region: COG2932 911045004701 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 911045004702 Catalytic site [active] 911045004703 Protein of unknown function (DUF952); Region: DUF952; cl01393 911045004704 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 911045004705 quinone interaction residues [chemical binding]; other site 911045004706 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 911045004707 active site 911045004708 catalytic residues [active] 911045004709 FMN binding site [chemical binding]; other site 911045004710 substrate binding site [chemical binding]; other site 911045004711 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 911045004712 MatE; Region: MatE; cl10513 911045004713 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 911045004714 DNA primase; Validated; Region: dnaG; PRK05667 911045004715 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 911045004716 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 911045004717 putative NAD(P) binding site [chemical binding]; other site 911045004718 substrate binding site [chemical binding]; other site 911045004719 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045004720 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045004721 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045004722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045004723 Coenzyme A binding pocket [chemical binding]; other site 911045004724 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 911045004725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045004726 Coenzyme A binding pocket [chemical binding]; other site 911045004727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045004728 Coenzyme A binding pocket [chemical binding]; other site 911045004729 Membrane transport protein; Region: Mem_trans; cl09117 911045004730 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 911045004731 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045004732 substrate binding site [chemical binding]; other site 911045004733 oxyanion hole (OAH) forming residues; other site 911045004734 trimer interface [polypeptide binding]; other site 911045004735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004736 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045004737 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 911045004738 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 911045004739 dimer interface [polypeptide binding]; other site 911045004740 active site 911045004741 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 911045004742 putative C-terminal domain interface [polypeptide binding]; other site 911045004743 putative GSH binding site (G-site) [chemical binding]; other site 911045004744 putative dimer interface [polypeptide binding]; other site 911045004745 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 911045004746 N-terminal domain interface [polypeptide binding]; other site 911045004747 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 911045004748 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 911045004749 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 911045004750 FAD binding site [chemical binding]; other site 911045004751 substrate binding site [chemical binding]; other site 911045004752 catalytic residues [active] 911045004753 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 911045004754 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045004755 dimerization interface [polypeptide binding]; other site 911045004756 putative DNA binding site [nucleotide binding]; other site 911045004757 putative Zn2+ binding site [ion binding]; other site 911045004758 NIPSNAP; Region: NIPSNAP; pfam07978 911045004759 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 911045004760 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 911045004761 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 911045004762 DNA binding residues [nucleotide binding] 911045004763 putative dimer interface [polypeptide binding]; other site 911045004764 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 911045004765 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 911045004766 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045004767 Sel1 repeat; Region: Sel1; cl02723 911045004768 Sel1 repeat; Region: Sel1; cl02723 911045004769 Sel1 repeat; Region: Sel1; cl02723 911045004770 Sel1 repeat; Region: Sel1; cl02723 911045004771 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 911045004772 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 911045004773 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 911045004774 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 911045004775 putative active site [active] 911045004776 putative metal binding site [ion binding]; other site 911045004777 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 911045004778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045004779 ATP binding site [chemical binding]; other site 911045004780 putative Mg++ binding site [ion binding]; other site 911045004781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045004782 nucleotide binding region [chemical binding]; other site 911045004783 ATP-binding site [chemical binding]; other site 911045004784 DEAD/H associated; Region: DEAD_assoc; pfam08494 911045004785 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045004786 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 911045004787 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 911045004788 putative catalytic residue [active] 911045004789 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 911045004790 active site 2 [active] 911045004791 active site 1 [active] 911045004792 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 911045004793 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 911045004794 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 911045004795 Sodium:solute symporter family; Region: SSF; cl00456 911045004796 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 911045004797 Sodium:solute symporter family; Region: SSF; cl00456 911045004798 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 911045004799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045004800 active site 911045004801 phosphorylation site [posttranslational modification] 911045004802 intermolecular recognition site; other site 911045004803 dimerization interface [polypeptide binding]; other site 911045004804 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045004805 DNA binding residues [nucleotide binding] 911045004806 dimerization interface [polypeptide binding]; other site 911045004807 Sodium:solute symporter family; Region: SSF; cl00456 911045004808 PAS fold; Region: PAS_7; pfam12860 911045004809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045004810 dimer interface [polypeptide binding]; other site 911045004811 phosphorylation site [posttranslational modification] 911045004812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045004813 ATP binding site [chemical binding]; other site 911045004814 Mg2+ binding site [ion binding]; other site 911045004815 G-X-G motif; other site 911045004816 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 911045004817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045004818 active site 911045004819 phosphorylation site [posttranslational modification] 911045004820 intermolecular recognition site; other site 911045004821 dimerization interface [polypeptide binding]; other site 911045004822 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 911045004823 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045004824 putative active site [active] 911045004825 heme pocket [chemical binding]; other site 911045004826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045004827 dimer interface [polypeptide binding]; other site 911045004828 phosphorylation site [posttranslational modification] 911045004829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045004830 ATP binding site [chemical binding]; other site 911045004831 Mg2+ binding site [ion binding]; other site 911045004832 G-X-G motif; other site 911045004833 response regulator FixJ; Provisional; Region: fixJ; PRK09390 911045004834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045004835 active site 911045004836 phosphorylation site [posttranslational modification] 911045004837 intermolecular recognition site; other site 911045004838 dimerization interface [polypeptide binding]; other site 911045004839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045004840 DNA binding residues [nucleotide binding] 911045004841 dimerization interface [polypeptide binding]; other site 911045004842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045004843 active site 911045004844 phosphorylation site [posttranslational modification] 911045004845 intermolecular recognition site; other site 911045004846 dimerization interface [polypeptide binding]; other site 911045004847 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045004848 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 911045004849 ligand binding site [chemical binding]; other site 911045004850 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 911045004851 putative switch regulator; other site 911045004852 non-specific DNA interactions [nucleotide binding]; other site 911045004853 DNA binding site [nucleotide binding] 911045004854 sequence specific DNA binding site [nucleotide binding]; other site 911045004855 putative cAMP binding site [chemical binding]; other site 911045004856 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 911045004857 HemN C-terminal domain; Region: HemN_C; pfam06969 911045004858 Putative ammonia monooxygenase; Region: AmoA; pfam05145 911045004859 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 911045004860 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 911045004861 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 911045004862 Low-spin heme binding site [chemical binding]; other site 911045004863 Putative water exit pathway; other site 911045004864 Binuclear center (active site) [active] 911045004865 Putative proton exit pathway; other site 911045004866 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 911045004867 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 911045004868 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 911045004869 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 911045004870 Cytochrome c; Region: Cytochrom_C; cl11414 911045004871 Cytochrome c; Region: Cytochrom_C; cl11414 911045004872 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 911045004873 4Fe-4S binding domain; Region: Fer4_5; pfam12801 911045004874 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 911045004875 FixH; Region: FixH; cl01254 911045004876 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 911045004877 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 911045004878 metal-binding site [ion binding] 911045004879 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 911045004880 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cl02586 911045004881 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045004882 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 911045004883 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 911045004884 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 911045004885 substrate-cofactor binding pocket; other site 911045004886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045004887 catalytic residue [active] 911045004888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045004889 Response regulator receiver domain; Region: Response_reg; pfam00072 911045004890 active site 911045004891 phosphorylation site [posttranslational modification] 911045004892 intermolecular recognition site; other site 911045004893 dimerization interface [polypeptide binding]; other site 911045004894 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 911045004895 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 911045004896 hinge; other site 911045004897 active site 911045004898 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 911045004899 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 911045004900 histidinol dehydrogenase; Region: hisD; TIGR00069 911045004901 NAD binding site [chemical binding]; other site 911045004902 dimerization interface [polypeptide binding]; other site 911045004903 product binding site; other site 911045004904 substrate binding site [chemical binding]; other site 911045004905 zinc binding site [ion binding]; other site 911045004906 catalytic residues [active] 911045004907 Uncharacterized protein family (UPF0262); Region: UPF0262; cl11489 911045004908 Low molecular weight phosphatase family; Region: LMWPc; cl00105 911045004909 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 911045004910 rRNA binding site [nucleotide binding]; other site 911045004911 predicted 30S ribosome binding site; other site 911045004912 Maf-like protein; Region: Maf; pfam02545 911045004913 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 911045004914 active site 911045004915 dimer interface [polypeptide binding]; other site 911045004916 Domain of unknown function (DUF329); Region: DUF329; cl01144 911045004917 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 911045004918 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 911045004919 active site 911045004920 metal binding site [ion binding]; metal-binding site 911045004921 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 911045004922 PaaX-like protein; Region: PaaX; pfam07848 911045004923 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 911045004924 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 911045004925 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 911045004926 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 911045004927 Phenylacetic acid degradation B; Region: PaaB; cl01371 911045004928 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 911045004929 Domain of unknown function DUF59; Region: DUF59; cl00941 911045004930 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 911045004931 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 911045004932 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 911045004933 FAD binding pocket [chemical binding]; other site 911045004934 FAD binding motif [chemical binding]; other site 911045004935 phosphate binding motif [ion binding]; other site 911045004936 beta-alpha-beta structure motif; other site 911045004937 NAD(p) ribose binding residues [chemical binding]; other site 911045004938 NAD binding pocket [chemical binding]; other site 911045004939 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 911045004940 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045004941 catalytic loop [active] 911045004942 iron binding site [ion binding]; other site 911045004943 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 911045004944 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 911045004945 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045004946 Helix-turn-helix domains; Region: HTH; cl00088 911045004947 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045004948 Sel1 repeat; Region: Sel1; cl02723 911045004949 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045004950 active site 911045004951 ATP binding site [chemical binding]; other site 911045004952 substrate binding site [chemical binding]; other site 911045004953 activation loop (A-loop); other site 911045004954 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045004955 active site 911045004956 ATP binding site [chemical binding]; other site 911045004957 substrate binding site [chemical binding]; other site 911045004958 activation loop (A-loop); other site 911045004959 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045004960 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 911045004961 C-terminal domain interface [polypeptide binding]; other site 911045004962 GSH binding site (G-site) [chemical binding]; other site 911045004963 dimer interface [polypeptide binding]; other site 911045004964 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 911045004965 dimer interface [polypeptide binding]; other site 911045004966 substrate binding pocket (H-site) [chemical binding]; other site 911045004967 N-terminal domain interface [polypeptide binding]; other site 911045004968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045004969 Helix-turn-helix domains; Region: HTH; cl00088 911045004970 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045004971 dimerization interface [polypeptide binding]; other site 911045004972 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 911045004973 maltose O-acetyltransferase; Provisional; Region: PRK10092 911045004974 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 911045004975 active site 911045004976 substrate binding site [chemical binding]; other site 911045004977 trimer interface [polypeptide binding]; other site 911045004978 CoA binding site [chemical binding]; other site 911045004979 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 911045004980 NADH(P)-binding; Region: NAD_binding_10; pfam13460 911045004981 NAD binding site [chemical binding]; other site 911045004982 substrate binding site [chemical binding]; other site 911045004983 putative active site [active] 911045004984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045004985 Helix-turn-helix domains; Region: HTH; cl00088 911045004986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045004987 Helix-turn-helix domains; Region: HTH; cl00088 911045004988 AMP-binding enzyme; Region: AMP-binding; cl15778 911045004989 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 911045004990 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 911045004991 CoenzymeA binding site [chemical binding]; other site 911045004992 subunit interaction site [polypeptide binding]; other site 911045004993 PHB binding site; other site 911045004994 enoyl-CoA hydratase; Provisional; Region: PRK08140 911045004995 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045004996 substrate binding site [chemical binding]; other site 911045004997 oxyanion hole (OAH) forming residues; other site 911045004998 trimer interface [polypeptide binding]; other site 911045004999 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 911045005000 NAD(P) binding site [chemical binding]; other site 911045005001 catalytic residues [active] 911045005002 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045005003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005004 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 911045005005 KduI/IolB family; Region: KduI; cl01508 911045005006 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 911045005007 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 911045005008 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045005009 PYR/PP interface [polypeptide binding]; other site 911045005010 dimer interface [polypeptide binding]; other site 911045005011 TPP binding site [chemical binding]; other site 911045005012 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 911045005013 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 911045005014 TPP-binding site; other site 911045005015 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045005016 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 911045005017 substrate binding site [chemical binding]; other site 911045005018 ATP binding site [chemical binding]; other site 911045005019 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 911045005020 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 911045005021 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 911045005022 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 911045005023 putative active site [active] 911045005024 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 911045005025 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 911045005026 putative ligand binding site [chemical binding]; other site 911045005027 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 911045005028 TM-ABC transporter signature motif; other site 911045005029 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 911045005030 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 911045005031 Walker A/P-loop; other site 911045005032 ATP binding site [chemical binding]; other site 911045005033 Q-loop/lid; other site 911045005034 ABC transporter signature motif; other site 911045005035 Walker B; other site 911045005036 D-loop; other site 911045005037 H-loop/switch region; other site 911045005038 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045005039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005040 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 911045005041 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045005042 DNA binding residues [nucleotide binding] 911045005043 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045005044 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 911045005045 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 911045005046 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 911045005047 Proline racemase; Region: Pro_racemase; pfam05544 911045005048 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 911045005049 Uncharacterized membrane protein [Function unknown]; Region: COG3949 911045005050 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045005051 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 911045005052 conserved cys residue [active] 911045005053 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 911045005054 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 911045005055 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 911045005056 homodimer interface [polypeptide binding]; other site 911045005057 NADP binding site [chemical binding]; other site 911045005058 substrate binding site [chemical binding]; other site 911045005059 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 911045005060 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 911045005061 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 911045005062 putative active site [active] 911045005063 putative substrate binding site [chemical binding]; other site 911045005064 putative cosubstrate binding site; other site 911045005065 catalytic site [active] 911045005066 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 911045005067 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045005068 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 911045005069 active site 911045005070 DctM-like transporters; Region: DctM; pfam06808 911045005071 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045005072 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045005073 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045005074 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045005075 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 911045005076 FCD domain; Region: FCD; cl11656 911045005077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045005078 DNA-binding site [nucleotide binding]; DNA binding site 911045005079 FCD domain; Region: FCD; cl11656 911045005080 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 911045005081 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 911045005082 tetramer interface [polypeptide binding]; other site 911045005083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045005084 catalytic residue [active] 911045005085 putative L-aspartate dehydrogenase; Provisional; Region: PRK13302 911045005086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005087 Domain of unknown function DUF108; Region: DUF108; pfam01958 911045005088 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 911045005089 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045005090 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 911045005091 active site 911045005092 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 911045005093 Amidase; Region: Amidase; cl11426 911045005094 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 911045005095 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 911045005096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005097 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 911045005098 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 911045005099 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 911045005100 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 911045005101 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045005102 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 911045005103 Helix-turn-helix domains; Region: HTH; cl00088 911045005104 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 911045005105 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 911045005106 metal binding site [ion binding]; metal-binding site 911045005107 putative dimer interface [polypeptide binding]; other site 911045005108 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 911045005109 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 911045005110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045005111 catalytic residue [active] 911045005112 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 911045005113 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 911045005114 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 911045005115 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 911045005116 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 911045005117 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 911045005118 Protein of unknown function (DUF770); Region: DUF770; cl01402 911045005119 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 911045005120 Protein of unknown function (DUF877); Region: DUF877; pfam05943 911045005121 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 911045005122 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 911045005123 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 911045005124 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 911045005125 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 911045005126 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 911045005127 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 911045005128 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 911045005129 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 911045005130 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 911045005131 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 911045005132 Clp amino terminal domain; Region: Clp_N; pfam02861 911045005133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045005134 Walker A motif; other site 911045005135 ATP binding site [chemical binding]; other site 911045005136 Walker B motif; other site 911045005137 arginine finger; other site 911045005138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045005139 Walker A motif; other site 911045005140 ATP binding site [chemical binding]; other site 911045005141 Walker B motif; other site 911045005142 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 911045005143 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 911045005144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045005145 Walker A motif; other site 911045005146 ATP binding site [chemical binding]; other site 911045005147 Walker B motif; other site 911045005148 arginine finger; other site 911045005149 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 911045005150 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 911045005151 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 911045005152 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 911045005153 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 911045005154 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 911045005155 active site turn [active] 911045005156 phosphorylation site [posttranslational modification] 911045005157 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 911045005158 active site turn [active] 911045005159 phosphorylation site [posttranslational modification] 911045005160 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 911045005161 HPr interaction site; other site 911045005162 glycerol kinase (GK) interaction site [polypeptide binding]; other site 911045005163 active site 911045005164 phosphorylation site [posttranslational modification] 911045005165 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 911045005166 dimerization domain swap beta strand [polypeptide binding]; other site 911045005167 regulatory protein interface [polypeptide binding]; other site 911045005168 active site 911045005169 regulatory phosphorylation site [posttranslational modification]; other site 911045005170 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 911045005171 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 911045005172 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 911045005173 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 911045005174 putative oxidoreductase; Provisional; Region: PRK11579 911045005175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005176 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 911045005177 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045005178 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 911045005179 substrate binding site [chemical binding]; other site 911045005180 ATP binding site [chemical binding]; other site 911045005181 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 911045005182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045005183 ATP binding site [chemical binding]; other site 911045005184 Mg2+ binding site [ion binding]; other site 911045005185 G-X-G motif; other site 911045005186 osmolarity response regulator; Provisional; Region: ompR; PRK09468 911045005187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045005188 active site 911045005189 phosphorylation site [posttranslational modification] 911045005190 intermolecular recognition site; other site 911045005191 dimerization interface [polypeptide binding]; other site 911045005192 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045005193 DNA binding site [nucleotide binding] 911045005194 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045005195 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045005196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005197 dimer interface [polypeptide binding]; other site 911045005198 conserved gate region; other site 911045005199 putative PBP binding loops; other site 911045005200 ABC-ATPase subunit interface; other site 911045005201 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045005202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005203 dimer interface [polypeptide binding]; other site 911045005204 conserved gate region; other site 911045005205 putative PBP binding loops; other site 911045005206 ABC-ATPase subunit interface; other site 911045005207 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045005208 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045005209 Walker A/P-loop; other site 911045005210 ATP binding site [chemical binding]; other site 911045005211 Q-loop/lid; other site 911045005212 ABC transporter signature motif; other site 911045005213 Walker B; other site 911045005214 D-loop; other site 911045005215 H-loop/switch region; other site 911045005216 TOBE domain; Region: TOBE_2; cl01440 911045005217 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 911045005218 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045005219 Helix-turn-helix domains; Region: HTH; cl00088 911045005220 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045005221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045005222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045005223 putative substrate translocation pore; other site 911045005224 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045005225 Helix-turn-helix domains; Region: HTH; cl00088 911045005226 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045005227 dimerization interface [polypeptide binding]; other site 911045005228 Transcriptional regulator [Transcription]; Region: IclR; COG1414 911045005229 Helix-turn-helix domains; Region: HTH; cl00088 911045005230 Bacterial transcriptional regulator; Region: IclR; pfam01614 911045005231 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 911045005232 DctM-like transporters; Region: DctM; pfam06808 911045005233 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045005234 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045005235 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045005236 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 911045005237 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 911045005238 active site pocket [active] 911045005239 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 911045005240 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 911045005241 inhibitor site; inhibition site 911045005242 active site 911045005243 dimer interface [polypeptide binding]; other site 911045005244 catalytic residue [active] 911045005245 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 911045005246 classical (c) SDRs; Region: SDR_c; cd05233 911045005247 NAD(P) binding site [chemical binding]; other site 911045005248 active site 911045005249 Domain of unknown function (DUF386); Region: DUF386; cl01047 911045005250 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 911045005251 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 911045005252 active site 911045005253 intersubunit interface [polypeptide binding]; other site 911045005254 catalytic residue [active] 911045005255 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 911045005256 Helix-turn-helix domains; Region: HTH; cl00088 911045005257 Bacterial transcriptional regulator; Region: IclR; pfam01614 911045005258 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 911045005259 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 911045005260 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 911045005261 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 911045005262 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 911045005263 heme binding site [chemical binding]; other site 911045005264 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 911045005265 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 911045005266 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045005267 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 911045005268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005269 dimer interface [polypeptide binding]; other site 911045005270 conserved gate region; other site 911045005271 putative PBP binding loops; other site 911045005272 ABC-ATPase subunit interface; other site 911045005273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045005274 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 911045005275 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045005276 Walker A/P-loop; other site 911045005277 ATP binding site [chemical binding]; other site 911045005278 Q-loop/lid; other site 911045005279 ABC transporter signature motif; other site 911045005280 Walker B; other site 911045005281 D-loop; other site 911045005282 H-loop/switch region; other site 911045005283 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 911045005284 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045005285 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 911045005286 putative dimer interface [polypeptide binding]; other site 911045005287 N-terminal domain interface [polypeptide binding]; other site 911045005288 putative substrate binding pocket (H-site) [chemical binding]; other site 911045005289 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 911045005290 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045005291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045005292 DNA-binding site [nucleotide binding]; DNA binding site 911045005293 FCD domain; Region: FCD; cl11656 911045005294 Amino acid synthesis; Region: AA_synth; pfam06684 911045005295 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045005296 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045005297 Flavin Reductases; Region: FlaRed; cl00801 911045005298 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 911045005299 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 911045005300 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045005301 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 911045005302 NAD(P) binding site [chemical binding]; other site 911045005303 catalytic residues [active] 911045005304 BCCT family transporter; Region: BCCT; cl00569 911045005305 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045005306 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 911045005307 tetramerization interface [polypeptide binding]; other site 911045005308 NAD(P) binding site [chemical binding]; other site 911045005309 catalytic residues [active] 911045005310 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 911045005311 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 911045005312 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045005313 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 911045005314 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 911045005315 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 911045005316 metal-binding site [ion binding] 911045005317 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 911045005318 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 911045005319 metal-binding site [ion binding] 911045005320 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 911045005321 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045005322 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 911045005323 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 911045005324 DNA binding residues [nucleotide binding] 911045005325 dimer interface [polypeptide binding]; other site 911045005326 copper binding site [ion binding]; other site 911045005327 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 911045005328 putative catalytic residue [active] 911045005329 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045005330 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045005331 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045005332 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 911045005333 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 911045005334 ATP-binding site [chemical binding]; other site 911045005335 Gluconate-6-phosphate binding site [chemical binding]; other site 911045005336 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045005337 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045005338 DNA binding site [nucleotide binding] 911045005339 domain linker motif; other site 911045005340 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 911045005341 putative ligand binding site [chemical binding]; other site 911045005342 putative dimerization interface [polypeptide binding]; other site 911045005343 D-lactate dehydrogenase; Provisional; Region: PRK11183 911045005344 FAD binding domain; Region: FAD_binding_4; pfam01565 911045005345 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 911045005346 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045005347 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045005348 DctM-like transporters; Region: DctM; pfam06808 911045005349 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045005350 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045005351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045005352 DNA-binding site [nucleotide binding]; DNA binding site 911045005353 FCD domain; Region: FCD; cl11656 911045005354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045005355 hypothetical protein; Provisional; Region: PRK14852 911045005356 hypothetical protein; Validated; Region: PRK08223 911045005357 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 911045005358 ATP binding site [chemical binding]; other site 911045005359 substrate interface [chemical binding]; other site 911045005360 NMT1-like family; Region: NMT1_2; cl15260 911045005361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045005362 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 911045005363 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 911045005364 Walker A/P-loop; other site 911045005365 ATP binding site [chemical binding]; other site 911045005366 Q-loop/lid; other site 911045005367 ABC transporter signature motif; other site 911045005368 Walker B; other site 911045005369 D-loop; other site 911045005370 H-loop/switch region; other site 911045005371 NnrS protein; Region: NnrS; cl01258 911045005372 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 911045005373 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 911045005374 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045005375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045005376 dimer interface [polypeptide binding]; other site 911045005377 phosphorylation site [posttranslational modification] 911045005378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045005379 ATP binding site [chemical binding]; other site 911045005380 Mg2+ binding site [ion binding]; other site 911045005381 G-X-G motif; other site 911045005382 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 911045005383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045005384 active site 911045005385 phosphorylation site [posttranslational modification] 911045005386 intermolecular recognition site; other site 911045005387 dimerization interface [polypeptide binding]; other site 911045005388 osmolarity response regulator; Provisional; Region: ompR; PRK09468 911045005389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045005390 active site 911045005391 phosphorylation site [posttranslational modification] 911045005392 intermolecular recognition site; other site 911045005393 dimerization interface [polypeptide binding]; other site 911045005394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045005395 DNA binding site [nucleotide binding] 911045005396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045005397 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 911045005398 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 911045005399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005400 dimer interface [polypeptide binding]; other site 911045005401 conserved gate region; other site 911045005402 putative PBP binding loops; other site 911045005403 ABC-ATPase subunit interface; other site 911045005404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005405 dimer interface [polypeptide binding]; other site 911045005406 conserved gate region; other site 911045005407 putative PBP binding loops; other site 911045005408 ABC-ATPase subunit interface; other site 911045005409 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045005410 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045005411 Walker A/P-loop; other site 911045005412 ATP binding site [chemical binding]; other site 911045005413 Q-loop/lid; other site 911045005414 ABC transporter signature motif; other site 911045005415 Walker B; other site 911045005416 D-loop; other site 911045005417 H-loop/switch region; other site 911045005418 TOBE domain; Region: TOBE_2; cl01440 911045005419 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 911045005420 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 911045005421 Cytochrome C'; Region: Cytochrom_C_2; cl01610 911045005422 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 911045005423 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 911045005424 Walker A/P-loop; other site 911045005425 ATP binding site [chemical binding]; other site 911045005426 Q-loop/lid; other site 911045005427 ABC transporter signature motif; other site 911045005428 Walker B; other site 911045005429 D-loop; other site 911045005430 H-loop/switch region; other site 911045005431 DevC protein; Region: devC; TIGR01185 911045005432 FtsX-like permease family; Region: FtsX; cl15850 911045005433 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 911045005434 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045005435 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 911045005436 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045005437 dimer interface [polypeptide binding]; other site 911045005438 putative CheW interface [polypeptide binding]; other site 911045005439 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 911045005440 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 911045005441 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045005442 TIGR03032 family protein; Region: TIGR03032 911045005443 Dehydratase family; Region: ILVD_EDD; cl00340 911045005444 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045005445 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 911045005446 tetramerization interface [polypeptide binding]; other site 911045005447 NAD(P) binding site [chemical binding]; other site 911045005448 catalytic residues [active] 911045005449 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 911045005450 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 911045005451 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 911045005452 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 911045005453 TPP-binding site [chemical binding]; other site 911045005454 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045005455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005456 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 911045005457 Transcriptional regulator [Transcription]; Region: IclR; COG1414 911045005458 Helix-turn-helix domains; Region: HTH; cl00088 911045005459 Bacterial transcriptional regulator; Region: IclR; pfam01614 911045005460 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045005461 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045005462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045005463 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 911045005464 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045005465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005466 dimer interface [polypeptide binding]; other site 911045005467 conserved gate region; other site 911045005468 putative PBP binding loops; other site 911045005469 ABC-ATPase subunit interface; other site 911045005470 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045005471 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045005472 Walker A/P-loop; other site 911045005473 ATP binding site [chemical binding]; other site 911045005474 Q-loop/lid; other site 911045005475 ABC transporter signature motif; other site 911045005476 Walker B; other site 911045005477 D-loop; other site 911045005478 H-loop/switch region; other site 911045005479 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 911045005480 diiron binding motif [ion binding]; other site 911045005481 Uncharacterized conserved protein [Function unknown]; Region: COG1633 911045005482 CCC1-related protein family; Region: CCC1_like_1; cd02437 911045005483 Membrane transport protein; Region: Mem_trans; cl09117 911045005484 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045005485 Helix-turn-helix domains; Region: HTH; cl00088 911045005486 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045005487 dimerization interface [polypeptide binding]; other site 911045005488 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 911045005489 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 911045005490 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 911045005491 active site 911045005492 substrate binding site [chemical binding]; other site 911045005493 catalytic site [active] 911045005494 RES domain; Region: RES; cl02411 911045005495 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 911045005496 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045005497 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 911045005498 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 911045005499 conserved cys residue [active] 911045005500 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 911045005501 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 911045005502 conserved cys residue [active] 911045005503 Helix-turn-helix domains; Region: HTH; cl00088 911045005504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005505 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 911045005506 potential catalytic triad [active] 911045005507 conserved cys residue [active] 911045005508 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 911045005509 Prostaglandin dehydrogenases; Region: PGDH; cd05288 911045005510 NAD(P) binding site [chemical binding]; other site 911045005511 substrate binding site [chemical binding]; other site 911045005512 dimer interface [polypeptide binding]; other site 911045005513 OsmC-like protein; Region: OsmC; cl00767 911045005514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005515 Helix-turn-helix domains; Region: HTH; cl00088 911045005516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005517 Helix-turn-helix domains; Region: HTH; cl00088 911045005518 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 911045005519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045005520 S-adenosylmethionine binding site [chemical binding]; other site 911045005521 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045005522 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045005523 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045005524 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045005525 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045005526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005527 NAD(P) binding site [chemical binding]; other site 911045005528 active site 911045005529 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 911045005530 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045005531 NAD binding site [chemical binding]; other site 911045005532 putative substrate binding site 2 [chemical binding]; other site 911045005533 putative substrate binding site 1 [chemical binding]; other site 911045005534 active site 911045005535 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 911045005536 benzoate transporter; Region: benE; TIGR00843 911045005537 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 911045005538 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 911045005539 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045005540 Walker A/P-loop; other site 911045005541 ATP binding site [chemical binding]; other site 911045005542 Q-loop/lid; other site 911045005543 ABC transporter signature motif; other site 911045005544 Walker B; other site 911045005545 D-loop; other site 911045005546 H-loop/switch region; other site 911045005547 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045005548 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045005549 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 911045005550 Walker A/P-loop; other site 911045005551 ATP binding site [chemical binding]; other site 911045005552 Q-loop/lid; other site 911045005553 ABC transporter signature motif; other site 911045005554 Walker B; other site 911045005555 D-loop; other site 911045005556 H-loop/switch region; other site 911045005557 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045005558 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 911045005559 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045005560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005561 dimer interface [polypeptide binding]; other site 911045005562 conserved gate region; other site 911045005563 putative PBP binding loops; other site 911045005564 ABC-ATPase subunit interface; other site 911045005565 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 911045005566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005567 dimer interface [polypeptide binding]; other site 911045005568 conserved gate region; other site 911045005569 putative PBP binding loops; other site 911045005570 ABC-ATPase subunit interface; other site 911045005571 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 911045005572 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 911045005573 peptide binding site [polypeptide binding]; other site 911045005574 UbiA prenyltransferase family; Region: UbiA; cl00337 911045005575 GtrA-like protein; Region: GtrA; cl00971 911045005576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045005577 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 911045005578 putative substrate translocation pore; other site 911045005579 Cache domain; Region: Cache_2; cl07034 911045005580 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045005581 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045005582 dimer interface [polypeptide binding]; other site 911045005583 putative CheW interface [polypeptide binding]; other site 911045005584 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045005585 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 911045005586 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 911045005587 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 911045005588 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 911045005589 ABC transporter; Region: ABC_tran_2; pfam12848 911045005590 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 911045005591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005592 Helix-turn-helix domains; Region: HTH; cl00088 911045005593 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 911045005594 [2Fe-2S] cluster binding site [ion binding]; other site 911045005595 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 911045005596 putative alpha subunit interface [polypeptide binding]; other site 911045005597 putative active site [active] 911045005598 putative substrate binding site [chemical binding]; other site 911045005599 Fe binding site [ion binding]; other site 911045005600 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 911045005601 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 911045005602 FAD binding pocket [chemical binding]; other site 911045005603 FAD binding motif [chemical binding]; other site 911045005604 phosphate binding motif [ion binding]; other site 911045005605 beta-alpha-beta structure motif; other site 911045005606 NAD binding pocket [chemical binding]; other site 911045005607 Helix-turn-helix domain; Region: HTH_18; pfam12833 911045005608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045005609 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 911045005610 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045005611 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045005612 Helix-turn-helix domains; Region: HTH; cl00088 911045005613 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045005614 dimerization interface [polypeptide binding]; other site 911045005615 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045005616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005617 NAD(P) binding site [chemical binding]; other site 911045005618 active site 911045005619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045005620 Helix-turn-helix domains; Region: HTH; cl00088 911045005621 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045005622 putative effector binding pocket; other site 911045005623 dimerization interface [polypeptide binding]; other site 911045005624 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 911045005625 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045005626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045005627 Coenzyme A binding pocket [chemical binding]; other site 911045005628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045005629 DNA-binding site [nucleotide binding]; DNA binding site 911045005630 FCD domain; Region: FCD; cl11656 911045005631 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045005632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045005633 Coenzyme A binding pocket [chemical binding]; other site 911045005634 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 911045005635 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045005636 DNA binding residues [nucleotide binding] 911045005637 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045005638 P-loop; other site 911045005639 Magnesium ion binding site [ion binding]; other site 911045005640 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045005641 Magnesium ion binding site [ion binding]; other site 911045005642 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 911045005643 ParB-like nuclease domain; Region: ParBc; cl02129 911045005644 replication initiation protein RepC; Provisional; Region: PRK13824 911045005645 Helix-turn-helix domains; Region: HTH; cl00088 911045005646 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 911045005647 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045005648 nudix motif; other site 911045005649 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045005650 nudix motif; other site 911045005651 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 911045005652 Membrane transport protein; Region: Mem_trans; cl09117 911045005653 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045005654 putative DNA binding site [nucleotide binding]; other site 911045005655 putative Zn2+ binding site [ion binding]; other site 911045005656 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 911045005657 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 911045005658 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 911045005659 Short C-terminal domain; Region: SHOCT; cl01373 911045005660 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 911045005661 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045005662 active site 911045005663 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 911045005664 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045005665 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 911045005666 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 911045005667 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 911045005668 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045005669 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 911045005670 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 911045005671 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 911045005672 NAD(P) binding site [chemical binding]; other site 911045005673 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045005674 classical (c) SDRs; Region: SDR_c; cd05233 911045005675 NAD(P) binding site [chemical binding]; other site 911045005676 active site 911045005677 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 911045005678 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 911045005679 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 911045005680 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045005681 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 911045005682 active site 911045005683 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045005684 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045005685 active site 911045005686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005687 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045005688 NAD(P) binding site [chemical binding]; other site 911045005689 active site 911045005690 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 911045005691 putative active site [active] 911045005692 putative catalytic site [active] 911045005693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005694 NAD(P) binding site [chemical binding]; other site 911045005695 active site 911045005696 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 911045005697 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 911045005698 putative active site [active] 911045005699 putative substrate binding site [chemical binding]; other site 911045005700 ATP binding site [chemical binding]; other site 911045005701 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 911045005702 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045005703 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045005704 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 911045005705 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 911045005706 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045005707 Walker A/P-loop; other site 911045005708 ATP binding site [chemical binding]; other site 911045005709 Q-loop/lid; other site 911045005710 ABC transporter signature motif; other site 911045005711 Walker B; other site 911045005712 D-loop; other site 911045005713 H-loop/switch region; other site 911045005714 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045005715 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 911045005716 Walker A/P-loop; other site 911045005717 ATP binding site [chemical binding]; other site 911045005718 Q-loop/lid; other site 911045005719 ABC transporter signature motif; other site 911045005720 Walker B; other site 911045005721 D-loop; other site 911045005722 H-loop/switch region; other site 911045005723 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 911045005724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005725 dimer interface [polypeptide binding]; other site 911045005726 conserved gate region; other site 911045005727 ABC-ATPase subunit interface; other site 911045005728 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045005729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005730 putative PBP binding loops; other site 911045005731 dimer interface [polypeptide binding]; other site 911045005732 ABC-ATPase subunit interface; other site 911045005733 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045005734 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045005735 SprA-related family; Region: SprA-related; pfam12118 911045005736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005737 Helix-turn-helix domains; Region: HTH; cl00088 911045005738 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 911045005739 DNA binding residues [nucleotide binding] 911045005740 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 911045005741 dimer interface [polypeptide binding]; other site 911045005742 putative metal binding site [ion binding]; other site 911045005743 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045005744 topology modulation protein; Reviewed; Region: PRK08118 911045005745 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045005746 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045005747 homotrimer interaction site [polypeptide binding]; other site 911045005748 putative active site [active] 911045005749 Helix-turn-helix domains; Region: HTH; cl00088 911045005750 WYL domain; Region: WYL; cl14852 911045005751 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 911045005752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005753 Helix-turn-helix domains; Region: HTH; cl00088 911045005754 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 911045005755 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 911045005756 putative active site [active] 911045005757 putative metal binding residues [ion binding]; other site 911045005758 signature motif; other site 911045005759 putative triphosphate binding site [ion binding]; other site 911045005760 dimer interface [polypeptide binding]; other site 911045005761 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 911045005762 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045005763 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045005764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045005765 Helix-turn-helix domains; Region: HTH; cl00088 911045005766 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045005767 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 911045005768 dimer interface [polypeptide binding]; other site 911045005769 substrate binding pocket (H-site) [chemical binding]; other site 911045005770 N-terminal domain interface [polypeptide binding]; other site 911045005771 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045005772 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 911045005773 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045005774 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 911045005775 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 911045005776 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 911045005777 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 911045005778 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 911045005779 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 911045005780 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045005781 enoyl-CoA hydratase; Provisional; Region: PRK07799 911045005782 substrate binding site [chemical binding]; other site 911045005783 oxyanion hole (OAH) forming residues; other site 911045005784 trimer interface [polypeptide binding]; other site 911045005785 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045005786 active site 911045005787 ATP binding site [chemical binding]; other site 911045005788 substrate binding site [chemical binding]; other site 911045005789 activation loop (A-loop); other site 911045005790 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045005791 active site 911045005792 ATP binding site [chemical binding]; other site 911045005793 substrate binding site [chemical binding]; other site 911045005794 activation loop (A-loop); other site 911045005795 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045005796 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045005797 ligand binding site [chemical binding]; other site 911045005798 flexible hinge region; other site 911045005799 Helix-turn-helix domains; Region: HTH; cl00088 911045005800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005801 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 911045005802 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 911045005803 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 911045005804 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045005805 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 911045005806 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 911045005807 Sulfate transporter family; Region: Sulfate_transp; cl15842 911045005808 high affinity sulphate transporter 1; Region: sulP; TIGR00815 911045005809 Sulfate transporter family; Region: Sulfate_transp; cl15842 911045005810 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 911045005811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005812 Helix-turn-helix domains; Region: HTH; cl00088 911045005813 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045005814 Spore germination protein; Region: Spore_permease; cl15802 911045005815 Methyltransferase domain; Region: Methyltransf_31; pfam13847 911045005816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045005817 S-adenosylmethionine binding site [chemical binding]; other site 911045005818 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 911045005819 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 911045005820 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 911045005821 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 911045005822 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 911045005823 [4Fe-4S] binding site [ion binding]; other site 911045005824 molybdopterin cofactor binding site; other site 911045005825 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 911045005826 molybdopterin cofactor binding site; other site 911045005827 NapD protein; Region: NapD; cl01163 911045005828 ferredoxin-type protein; Provisional; Region: PRK10194 911045005829 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 911045005830 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 911045005831 4Fe-4S binding domain; Region: Fer4; cl02805 911045005832 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 911045005833 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 911045005834 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045005835 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045005836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005837 Helix-turn-helix domains; Region: HTH; cl00088 911045005838 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 911045005839 CoenzymeA binding site [chemical binding]; other site 911045005840 subunit interaction site [polypeptide binding]; other site 911045005841 PHB binding site; other site 911045005842 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 911045005843 YadA-like C-terminal region; Region: YadA; pfam03895 911045005844 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045005845 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 911045005846 substrate binding site [chemical binding]; other site 911045005847 ATP binding site [chemical binding]; other site 911045005848 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 911045005849 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 911045005850 active site 911045005851 intersubunit interface [polypeptide binding]; other site 911045005852 zinc binding site [ion binding]; other site 911045005853 Na+ binding site [ion binding]; other site 911045005854 HupE / UreJ protein; Region: HupE_UreJ; cl01011 911045005855 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 911045005856 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 911045005857 Sulfatase; Region: Sulfatase; cl10460 911045005858 choline-sulfatase; Region: chol_sulfatase; TIGR03417 911045005859 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 911045005860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045005861 Helix-turn-helix domains; Region: HTH; cl00088 911045005862 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045005863 dimerization interface [polypeptide binding]; other site 911045005864 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 911045005865 active site 911045005866 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 911045005867 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045005868 active site 911045005869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045005870 H+ Antiporter protein; Region: 2A0121; TIGR00900 911045005871 putative substrate translocation pore; other site 911045005872 EamA-like transporter family; Region: EamA; cl01037 911045005873 glycerate dehydrogenase; Provisional; Region: PRK06932 911045005874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005875 Helix-turn-helix domains; Region: HTH; cl00088 911045005876 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045005877 catalytic core [active] 911045005878 extended (e) SDRs; Region: SDR_e; cd08946 911045005879 active site 911045005880 substrate binding site [chemical binding]; other site 911045005881 Protein of unknown function, DUF606; Region: DUF606; cl01273 911045005882 Integral membrane protein TerC family; Region: TerC; cl10468 911045005883 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045005884 ligand binding site [chemical binding]; other site 911045005885 flexible hinge region; other site 911045005886 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045005887 AAA domain; Region: AAA_33; pfam13671 911045005888 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045005889 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045005890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045005891 Helix-turn-helix domains; Region: HTH; cl00088 911045005892 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 911045005893 substrate binding pocket [chemical binding]; other site 911045005894 dimerization interface [polypeptide binding]; other site 911045005895 Cupin domain; Region: Cupin_2; cl09118 911045005896 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045005897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045005898 LysE type translocator; Region: LysE; cl00565 911045005899 Protein of unknown function, DUF488; Region: DUF488; cl01246 911045005900 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 911045005901 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045005902 N-terminal plug; other site 911045005903 ligand-binding site [chemical binding]; other site 911045005904 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 911045005905 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045005906 Walker A/P-loop; other site 911045005907 ATP binding site [chemical binding]; other site 911045005908 Q-loop/lid; other site 911045005909 ABC transporter signature motif; other site 911045005910 Walker B; other site 911045005911 D-loop; other site 911045005912 H-loop/switch region; other site 911045005913 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 911045005914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045005915 putative substrate translocation pore; other site 911045005916 H+ Antiporter protein; Region: 2A0121; TIGR00900 911045005917 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 911045005918 Protein of unknown function, DUF; Region: DUF411; cl01142 911045005919 Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534 911045005920 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045005921 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045005922 active site 911045005923 metal binding site [ion binding]; metal-binding site 911045005924 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005925 Helix-turn-helix domains; Region: HTH; cl00088 911045005926 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045005927 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045005928 active site 911045005929 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 911045005930 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045005931 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045005932 classical (c) SDRs; Region: SDR_c; cd05233 911045005933 NAD(P) binding site [chemical binding]; other site 911045005934 active site 911045005935 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045005936 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 911045005937 putative catalytic residues [active] 911045005938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005939 Helix-turn-helix domains; Region: HTH; cl00088 911045005940 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045005941 Helix-turn-helix domains; Region: HTH; cl00088 911045005942 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045005943 dimerization interface [polypeptide binding]; other site 911045005944 Transcriptional activator [Transcription]; Region: ChrR; COG3806 911045005945 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 911045005946 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 911045005947 dimer interface [polypeptide binding]; other site 911045005948 PYR/PP interface [polypeptide binding]; other site 911045005949 TPP binding site [chemical binding]; other site 911045005950 substrate binding site [chemical binding]; other site 911045005951 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 911045005952 TPP-binding site [chemical binding]; other site 911045005953 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 911045005954 Cache domain; Region: Cache_1; pfam02743 911045005955 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045005956 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045005957 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045005958 dimer interface [polypeptide binding]; other site 911045005959 putative CheW interface [polypeptide binding]; other site 911045005960 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 911045005961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005962 Helix-turn-helix domains; Region: HTH; cl00088 911045005963 Protein of unknown function, DUF417; Region: DUF417; cl01162 911045005964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005965 Helix-turn-helix domains; Region: HTH; cl00088 911045005966 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 911045005967 Ligand Binding Site [chemical binding]; other site 911045005968 HupE / UreJ protein; Region: HupE_UreJ; cl01011 911045005969 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 911045005970 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 911045005971 putative active site [active] 911045005972 putative substrate binding site [chemical binding]; other site 911045005973 ATP binding site [chemical binding]; other site 911045005974 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 911045005975 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 911045005976 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 911045005977 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 911045005978 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 911045005979 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045005980 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 911045005981 sensory histidine kinase AtoS; Provisional; Region: PRK11360 911045005982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045005983 dimer interface [polypeptide binding]; other site 911045005984 phosphorylation site [posttranslational modification] 911045005985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045005986 ATP binding site [chemical binding]; other site 911045005987 Mg2+ binding site [ion binding]; other site 911045005988 G-X-G motif; other site 911045005989 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 911045005990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045005991 active site 911045005992 phosphorylation site [posttranslational modification] 911045005993 intermolecular recognition site; other site 911045005994 dimerization interface [polypeptide binding]; other site 911045005995 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045005996 DNA binding residues [nucleotide binding] 911045005997 dimerization interface [polypeptide binding]; other site 911045005998 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 911045005999 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045006000 P-loop motif; other site 911045006001 ATP binding site [chemical binding]; other site 911045006002 Chloramphenicol (Cm) binding site [chemical binding]; other site 911045006003 catalytic residue [active] 911045006004 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 911045006005 putative trimer interface [polypeptide binding]; other site 911045006006 putative CoA binding site [chemical binding]; other site 911045006007 Ceramidase; Region: Ceramidase; pfam05875 911045006008 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045006009 tetrathionate reductase subunit B; Provisional; Region: PRK14993 911045006010 4Fe-4S binding domain; Region: Fer4; cl02805 911045006011 Polysulphide reductase, NrfD; Region: NrfD; cl01295 911045006012 tetrathionate reductase subunit A; Provisional; Region: PRK14991 911045006013 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 911045006014 molybdopterin cofactor binding site; other site 911045006015 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 911045006016 putative molybdopterin cofactor binding site [chemical binding]; other site 911045006017 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 911045006018 putative molybdopterin cofactor binding site; other site 911045006019 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 911045006020 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 911045006021 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 911045006022 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 911045006023 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045006024 active site 911045006025 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045006026 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 911045006027 active site 911045006028 metal binding site [ion binding]; metal-binding site 911045006029 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 911045006030 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045006031 dimer interface [polypeptide binding]; other site 911045006032 putative metal binding site [ion binding]; other site 911045006033 enoyl-CoA hydratase; Provisional; Region: PRK08140 911045006034 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045006035 substrate binding site [chemical binding]; other site 911045006036 oxyanion hole (OAH) forming residues; other site 911045006037 trimer interface [polypeptide binding]; other site 911045006038 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045006039 Helix-turn-helix domains; Region: HTH; cl00088 911045006040 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045006041 dimerization interface [polypeptide binding]; other site 911045006042 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045006043 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045006044 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045006045 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045006046 substrate binding pocket [chemical binding]; other site 911045006047 membrane-bound complex binding site; other site 911045006048 hinge residues; other site 911045006049 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 911045006050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006051 dimer interface [polypeptide binding]; other site 911045006052 conserved gate region; other site 911045006053 putative PBP binding loops; other site 911045006054 ABC-ATPase subunit interface; other site 911045006055 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045006056 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045006057 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045006058 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 911045006059 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 911045006060 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 911045006061 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045006062 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045006063 Helix-turn-helix domains; Region: HTH; cl00088 911045006064 Helix-turn-helix domains; Region: HTH; cl00088 911045006065 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 911045006066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045006067 FeS/SAM binding site; other site 911045006068 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 911045006069 Cytochrome c; Region: Cytochrom_C; cl11414 911045006070 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 911045006071 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 911045006072 structural tetrad; other site 911045006073 hypothetical protein; Provisional; Region: PRK02395 911045006074 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 911045006075 putative active site [active] 911045006076 peroxiredoxin; Provisional; Region: PRK13189 911045006077 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 911045006078 dimer interface [polypeptide binding]; other site 911045006079 decamer (pentamer of dimers) interface [polypeptide binding]; other site 911045006080 catalytic triad [active] 911045006081 Helix-turn-helix domains; Region: HTH; cl00088 911045006082 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 911045006083 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 911045006084 dimerization interface [polypeptide binding]; other site 911045006085 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045006086 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045006087 ligand binding site [chemical binding]; other site 911045006088 flexible hinge region; other site 911045006089 Helix-turn-helix domains; Region: HTH; cl00088 911045006090 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045006091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045006092 Coenzyme A binding pocket [chemical binding]; other site 911045006093 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 911045006094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045006095 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 911045006096 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045006097 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045006098 catalytic residue [active] 911045006099 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045006100 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 911045006101 Ca2+ binding site [ion binding]; other site 911045006102 Calx-beta domain; Region: Calx-beta; cl02522 911045006103 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 911045006104 generic binding surface I; other site 911045006105 generic binding surface II; other site 911045006106 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045006107 putative catalytic site [active] 911045006108 putative metal binding site [ion binding]; other site 911045006109 putative phosphate binding site [ion binding]; other site 911045006110 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045006111 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045006112 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045006113 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 911045006114 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045006115 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 911045006116 Walker A/P-loop; other site 911045006117 ATP binding site [chemical binding]; other site 911045006118 Q-loop/lid; other site 911045006119 ABC transporter signature motif; other site 911045006120 Walker B; other site 911045006121 D-loop; other site 911045006122 H-loop/switch region; other site 911045006123 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 911045006124 active site 911045006125 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045006126 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 911045006127 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 911045006128 active site pocket [active] 911045006129 BCCT family transporter; Region: BCCT; cl00569 911045006130 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 911045006131 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 911045006132 active site pocket [active] 911045006133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045006134 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 911045006135 Protein of unknown function (DUF4246); Region: DUF4246; pfam14033 911045006136 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 911045006137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045006138 DNA-binding site [nucleotide binding]; DNA binding site 911045006139 FCD domain; Region: FCD; cl11656 911045006140 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 911045006141 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 911045006142 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 911045006143 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 911045006144 Walker A/P-loop; other site 911045006145 ATP binding site [chemical binding]; other site 911045006146 Q-loop/lid; other site 911045006147 ABC transporter signature motif; other site 911045006148 Walker B; other site 911045006149 D-loop; other site 911045006150 H-loop/switch region; other site 911045006151 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 911045006152 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 911045006153 TM-ABC transporter signature motif; other site 911045006154 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 911045006155 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 911045006156 putative ligand binding site [chemical binding]; other site 911045006157 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 911045006158 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045006159 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 911045006160 Amidase; Region: Amidase; cl11426 911045006161 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 911045006162 Helix-turn-helix domains; Region: HTH; cl00088 911045006163 WYL domain; Region: WYL; cl14852 911045006164 NMT1-like family; Region: NMT1_2; cl15260 911045006165 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045006166 DctM-like transporters; Region: DctM; pfam06808 911045006167 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 911045006168 active site 911045006169 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045006170 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045006171 Walker A/P-loop; other site 911045006172 ATP binding site [chemical binding]; other site 911045006173 Q-loop/lid; other site 911045006174 ABC transporter signature motif; other site 911045006175 Walker B; other site 911045006176 D-loop; other site 911045006177 H-loop/switch region; other site 911045006178 TOBE domain; Region: TOBE_2; cl01440 911045006179 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 911045006180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006181 dimer interface [polypeptide binding]; other site 911045006182 conserved gate region; other site 911045006183 putative PBP binding loops; other site 911045006184 ABC-ATPase subunit interface; other site 911045006185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006186 dimer interface [polypeptide binding]; other site 911045006187 conserved gate region; other site 911045006188 putative PBP binding loops; other site 911045006189 ABC-ATPase subunit interface; other site 911045006190 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 911045006191 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045006192 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045006193 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045006194 DNA binding site [nucleotide binding] 911045006195 domain linker motif; other site 911045006196 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 911045006197 putative dimerization interface [polypeptide binding]; other site 911045006198 putative ligand binding site [chemical binding]; other site 911045006199 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 911045006200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045006201 NAD(P) binding site [chemical binding]; other site 911045006202 active site 911045006203 Flavoprotein; Region: Flavoprotein; cl08021 911045006204 Flavoprotein; Region: Flavoprotein; cl08021 911045006205 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 911045006206 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 911045006207 active site 911045006208 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 911045006209 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 911045006210 transmembrane helices; other site 911045006211 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 911045006212 homodimer interaction site [polypeptide binding]; other site 911045006213 cofactor binding site; other site 911045006214 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 911045006215 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045006216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045006217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006218 dimer interface [polypeptide binding]; other site 911045006219 conserved gate region; other site 911045006220 putative PBP binding loops; other site 911045006221 ABC-ATPase subunit interface; other site 911045006222 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 911045006223 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045006224 Walker A/P-loop; other site 911045006225 ATP binding site [chemical binding]; other site 911045006226 Q-loop/lid; other site 911045006227 ABC transporter signature motif; other site 911045006228 Walker B; other site 911045006229 D-loop; other site 911045006230 H-loop/switch region; other site 911045006231 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045006232 Walker A/P-loop; other site 911045006233 ATP binding site [chemical binding]; other site 911045006234 Q-loop/lid; other site 911045006235 ABC transporter signature motif; other site 911045006236 Walker B; other site 911045006237 D-loop; other site 911045006238 H-loop/switch region; other site 911045006239 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 911045006240 putative active site pocket [active] 911045006241 dimerization interface [polypeptide binding]; other site 911045006242 putative catalytic residue [active] 911045006243 Peptidase family M23; Region: Peptidase_M23; pfam01551 911045006244 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045006245 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 911045006246 active site 911045006247 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045006248 active site 911045006249 Prephenate dehydratase; Region: PDT; pfam00800 911045006250 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045006251 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045006252 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 911045006253 putative N-terminal domain interface [polypeptide binding]; other site 911045006254 putative dimer interface [polypeptide binding]; other site 911045006255 putative substrate binding pocket (H-site) [chemical binding]; other site 911045006256 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045006257 Helix-turn-helix domains; Region: HTH; cl00088 911045006258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045006259 dimerization interface [polypeptide binding]; other site 911045006260 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045006261 Helix-turn-helix domains; Region: HTH; cl00088 911045006262 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045006263 dimerization interface [polypeptide binding]; other site 911045006264 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045006265 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045006266 substrate binding pocket [chemical binding]; other site 911045006267 membrane-bound complex binding site; other site 911045006268 hinge residues; other site 911045006269 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 911045006270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006271 dimer interface [polypeptide binding]; other site 911045006272 conserved gate region; other site 911045006273 putative PBP binding loops; other site 911045006274 ABC-ATPase subunit interface; other site 911045006275 Peptidase C26; Region: Peptidase_C26; pfam07722 911045006276 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 911045006277 catalytic triad [active] 911045006278 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 911045006279 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 911045006280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045006281 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045006282 catalytic core [active] 911045006283 DctM-like transporters; Region: DctM; pfam06808 911045006284 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045006285 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045006286 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045006287 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045006288 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 911045006289 Helix-turn-helix domains; Region: HTH; cl00088 911045006290 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045006291 dimerization interface [polypeptide binding]; other site 911045006292 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 911045006293 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 911045006294 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 911045006295 multimer interface [polypeptide binding]; other site 911045006296 heterodimer interface [polypeptide binding]; other site 911045006297 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 911045006298 active site 911045006299 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 911045006300 heterodimer interface [polypeptide binding]; other site 911045006301 active site 911045006302 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045006303 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045006304 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 911045006305 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 911045006306 dimer interface [polypeptide binding]; other site 911045006307 active site 911045006308 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 911045006309 Lyase; Region: Lyase_1; pfam00206 911045006310 tetramer interface [polypeptide binding]; other site 911045006311 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 911045006312 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 911045006313 metal binding site [ion binding]; metal-binding site 911045006314 putative dimer interface [polypeptide binding]; other site 911045006315 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 911045006316 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 911045006317 Baseplate J-like protein; Region: Baseplate_J; cl01294 911045006318 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 911045006319 TIR domain; Region: TIR_2; cl15770 911045006320 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 911045006321 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 911045006322 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 911045006323 Mu-like prophage protein [General function prediction only]; Region: COG3941 911045006324 tape measure domain; Region: tape_meas_nterm; TIGR02675 911045006325 membrane protein P6; Region: PHA01399 911045006326 Phage-related protein [Function unknown]; Region: COG5412 911045006327 Phage tail tube protein FII; Region: Phage_tube; cl01390 911045006328 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 911045006329 Gp37 protein; Region: Gp37; pfam09646 911045006330 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 911045006331 Helix-turn-helix domains; Region: HTH; cl00088 911045006332 Helix-turn-helix domains; Region: HTH; cl00088 911045006333 Winged helix-turn helix; Region: HTH_29; pfam13551 911045006334 Helix-turn-helix domains; Region: HTH; cl00088 911045006335 Integrase core domain; Region: rve; cl01316 911045006336 multidrug efflux protein; Reviewed; Region: PRK09579 911045006337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045006338 Helix-turn-helix domains; Region: HTH; cl00088 911045006339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045006340 binding surface 911045006341 TPR motif; other site 911045006342 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 911045006343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045006344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045006345 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045006346 NAD(P) binding site [chemical binding]; other site 911045006347 active site 911045006348 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 911045006349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045006350 NAD(P) binding site [chemical binding]; other site 911045006351 active site 911045006352 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 911045006353 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045006354 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045006355 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 911045006356 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 911045006357 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 911045006358 active site 911045006359 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045006360 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 911045006361 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045006362 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045006363 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045006364 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045006365 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045006366 Helix-turn-helix domains; Region: HTH; cl00088 911045006367 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 911045006368 substrate binding pocket [chemical binding]; other site 911045006369 dimerization interface [polypeptide binding]; other site 911045006370 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 911045006371 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045006372 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 911045006373 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 911045006374 Class I ribonucleotide reductase; Region: RNR_I; cd01679 911045006375 active site 911045006376 dimer interface [polypeptide binding]; other site 911045006377 catalytic residues [active] 911045006378 effector binding site; other site 911045006379 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 911045006380 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 911045006381 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 911045006382 dimer interface [polypeptide binding]; other site 911045006383 putative radical transfer pathway; other site 911045006384 diiron center [ion binding]; other site 911045006385 tyrosyl radical; other site 911045006386 FAD dependent oxidoreductase; Region: DAO; pfam01266 911045006387 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045006388 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045006389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045006390 DNA-binding site [nucleotide binding]; DNA binding site 911045006391 FCD domain; Region: FCD; cl11656 911045006392 NMT1-like family; Region: NMT1_2; cl15260 911045006393 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045006394 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045006395 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 911045006396 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 911045006397 Helix-turn-helix domains; Region: HTH; cl00088 911045006398 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045006399 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 911045006400 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045006401 substrate binding site [chemical binding]; other site 911045006402 ATP binding site [chemical binding]; other site 911045006403 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 911045006404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045006405 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 911045006406 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 911045006407 active site 911045006408 catalytic residues [active] 911045006409 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 911045006410 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 911045006411 hypothetical protein; Provisional; Region: PRK08185 911045006412 intersubunit interface [polypeptide binding]; other site 911045006413 active site 911045006414 zinc binding site [ion binding]; other site 911045006415 Na+ binding site [ion binding]; other site 911045006416 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 911045006417 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 911045006418 hexamer (dimer of trimers) interface [polypeptide binding]; other site 911045006419 trimer interface [polypeptide binding]; other site 911045006420 substrate binding site [chemical binding]; other site 911045006421 Mn binding site [ion binding]; other site 911045006422 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045006423 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045006424 DctM-like transporters; Region: DctM; pfam06808 911045006425 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045006426 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045006427 alpha-glucosidase; Provisional; Region: PRK10426 911045006428 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 911045006429 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 911045006430 putative active site [active] 911045006431 putative catalytic site [active] 911045006432 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 911045006433 Dak1 domain; Region: Dak1; pfam02733 911045006434 DAK2 domain; Region: Dak2; cl03685 911045006435 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 911045006436 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 911045006437 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 911045006438 dimerization domain swap beta strand [polypeptide binding]; other site 911045006439 regulatory protein interface [polypeptide binding]; other site 911045006440 active site 911045006441 regulatory phosphorylation site [posttranslational modification]; other site 911045006442 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 911045006443 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 911045006444 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 911045006445 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 911045006446 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 911045006447 dimer interface [polypeptide binding]; other site 911045006448 active site 911045006449 metal binding site [ion binding]; metal-binding site 911045006450 Helix-turn-helix domains; Region: HTH; cl00088 911045006451 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 911045006452 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 911045006453 metal binding site [ion binding]; metal-binding site 911045006454 putative dimer interface [polypeptide binding]; other site 911045006455 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 911045006456 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 911045006457 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045006458 catalytic residue [active] 911045006459 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 911045006460 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 911045006461 Walker A/P-loop; other site 911045006462 ATP binding site [chemical binding]; other site 911045006463 Q-loop/lid; other site 911045006464 ABC transporter signature motif; other site 911045006465 Walker B; other site 911045006466 D-loop; other site 911045006467 H-loop/switch region; other site 911045006468 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 911045006469 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045006470 ABC-ATPase subunit interface; other site 911045006471 dimer interface [polypeptide binding]; other site 911045006472 putative PBP binding regions; other site 911045006473 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045006474 ABC-ATPase subunit interface; other site 911045006475 dimer interface [polypeptide binding]; other site 911045006476 putative PBP binding regions; other site 911045006477 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 911045006478 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 911045006479 siderophore binding site; other site 911045006480 putative MFS family transporter protein; Provisional; Region: PRK03633 911045006481 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 911045006482 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 911045006483 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 911045006484 Ligand binding site; other site 911045006485 Putative Catalytic site; other site 911045006486 DXD motif; other site 911045006487 YdjC-like protein; Region: YdjC; cl01344 911045006488 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045006489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045006490 Coenzyme A binding pocket [chemical binding]; other site 911045006491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045006492 Coenzyme A binding pocket [chemical binding]; other site 911045006493 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 911045006494 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 911045006495 N- and C-terminal domain interface [polypeptide binding]; other site 911045006496 putative active site [active] 911045006497 putative MgATP binding site [chemical binding]; other site 911045006498 catalytic site [active] 911045006499 metal binding site [ion binding]; metal-binding site 911045006500 carbohydrate binding site [chemical binding]; other site 911045006501 putative homodimer interface [polypeptide binding]; other site 911045006502 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045006503 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045006504 DNA binding site [nucleotide binding] 911045006505 domain linker motif; other site 911045006506 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045006507 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045006508 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 911045006509 cleavage site 911045006510 active site 911045006511 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 911045006512 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 911045006513 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045006514 G1 box; other site 911045006515 GTP/Mg2+ binding site [chemical binding]; other site 911045006516 G2 box; other site 911045006517 Switch I region; other site 911045006518 G3 box; other site 911045006519 Switch II region; other site 911045006520 G4 box; other site 911045006521 G5 box; other site 911045006522 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 911045006523 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 911045006524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045006525 S-adenosylmethionine binding site [chemical binding]; other site 911045006526 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 911045006527 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 911045006528 active site 911045006529 uracil binding [chemical binding]; other site 911045006530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045006531 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045006532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045006533 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 911045006534 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 911045006535 Ion channel; Region: Ion_trans_2; cl11596 911045006536 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 911045006537 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045006538 ABC transporter ATPase component; Reviewed; Region: PRK11147 911045006539 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 911045006540 ABC transporter signature motif; other site 911045006541 Walker B; other site 911045006542 D-loop; other site 911045006543 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 911045006544 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045006545 H-loop/switch region; other site 911045006546 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 911045006547 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 911045006548 peptide binding site [polypeptide binding]; other site 911045006549 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 911045006550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006551 dimer interface [polypeptide binding]; other site 911045006552 conserved gate region; other site 911045006553 putative PBP binding loops; other site 911045006554 ABC-ATPase subunit interface; other site 911045006555 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045006556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006557 dimer interface [polypeptide binding]; other site 911045006558 conserved gate region; other site 911045006559 ABC-ATPase subunit interface; other site 911045006560 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 911045006561 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045006562 Walker A/P-loop; other site 911045006563 ATP binding site [chemical binding]; other site 911045006564 Q-loop/lid; other site 911045006565 ABC transporter signature motif; other site 911045006566 Walker B; other site 911045006567 D-loop; other site 911045006568 H-loop/switch region; other site 911045006569 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045006570 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045006571 Walker A/P-loop; other site 911045006572 ATP binding site [chemical binding]; other site 911045006573 Q-loop/lid; other site 911045006574 ABC transporter signature motif; other site 911045006575 Walker B; other site 911045006576 D-loop; other site 911045006577 H-loop/switch region; other site 911045006578 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 911045006579 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045006580 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045006581 putative DNA binding site [nucleotide binding]; other site 911045006582 putative Zn2+ binding site [ion binding]; other site 911045006583 Helix-turn-helix domains; Region: HTH; cl00088 911045006584 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 911045006585 active site 911045006586 dimer interface [polypeptide binding]; other site 911045006587 Cupin domain; Region: Cupin_2; cl09118 911045006588 Haemolysin-III related; Region: HlyIII; cl03831 911045006589 HerA helicase [Replication, recombination, and repair]; Region: COG0433 911045006590 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045006591 EamA-like transporter family; Region: EamA; cl01037 911045006592 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045006593 EamA-like transporter family; Region: EamA; cl01037 911045006594 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 911045006595 active site 911045006596 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 911045006597 active site 911045006598 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 911045006599 active site 911045006600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045006601 dimerization interface [polypeptide binding]; other site 911045006602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045006603 dimer interface [polypeptide binding]; other site 911045006604 phosphorylation site [posttranslational modification] 911045006605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045006606 ATP binding site [chemical binding]; other site 911045006607 Mg2+ binding site [ion binding]; other site 911045006608 G-X-G motif; other site 911045006609 osmolarity response regulator; Provisional; Region: ompR; PRK09468 911045006610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045006611 active site 911045006612 phosphorylation site [posttranslational modification] 911045006613 intermolecular recognition site; other site 911045006614 dimerization interface [polypeptide binding]; other site 911045006615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045006616 DNA binding site [nucleotide binding] 911045006617 EF-hand domain pair; Region: EF_hand_5; pfam13499 911045006618 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302 911045006619 Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; Region: FRQ1; COG5126 911045006620 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 911045006621 Sulfate transporter family; Region: Sulfate_transp; cl15842 911045006622 Sulfate transporter family; Region: Sulfate_transp; cl15842 911045006623 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 911045006624 hypothetical protein; Provisional; Region: PRK08912 911045006625 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045006626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045006627 homodimer interface [polypeptide binding]; other site 911045006628 catalytic residue [active] 911045006629 L-asparaginase II; Region: Asparaginase_II; cl01842 911045006630 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 911045006631 membrane ATPase/protein kinase; Provisional; Region: PRK09435 911045006632 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 911045006633 Walker A; other site 911045006634 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 911045006635 hypothetical protein; Provisional; Region: PRK06194 911045006636 classical (c) SDRs; Region: SDR_c; cd05233 911045006637 NAD(P) binding site [chemical binding]; other site 911045006638 active site 911045006639 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 911045006640 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 911045006641 active site 911045006642 substrate binding site [chemical binding]; other site 911045006643 coenzyme B12 binding site [chemical binding]; other site 911045006644 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 911045006645 B12 binding site [chemical binding]; other site 911045006646 cobalt ligand [ion binding]; other site 911045006647 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 911045006648 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 911045006649 heterodimer interface [polypeptide binding]; other site 911045006650 substrate interaction site [chemical binding]; other site 911045006651 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 911045006652 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 911045006653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045006654 DNA binding residues [nucleotide binding] 911045006655 dimerization interface [polypeptide binding]; other site 911045006656 galactokinase; Provisional; Region: PRK03817 911045006657 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 911045006658 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 911045006659 metal binding site [ion binding]; metal-binding site 911045006660 putative dimer interface [polypeptide binding]; other site 911045006661 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 911045006662 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 911045006663 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 911045006664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045006665 motif II; other site 911045006666 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 911045006667 homodimer interface [polypeptide binding]; other site 911045006668 substrate-cofactor binding pocket; other site 911045006669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045006670 catalytic residue [active] 911045006671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045006672 putative substrate translocation pore; other site 911045006673 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 911045006674 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 911045006675 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 911045006676 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 911045006677 Helix-turn-helix domains; Region: HTH; cl00088 911045006678 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 911045006679 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 911045006680 [2Fe-2S] cluster binding site [ion binding]; other site 911045006681 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 911045006682 alpha subunit interface [polypeptide binding]; other site 911045006683 active site 911045006684 substrate binding site [chemical binding]; other site 911045006685 Fe binding site [ion binding]; other site 911045006686 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 911045006687 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 911045006688 FAD binding pocket [chemical binding]; other site 911045006689 FAD binding motif [chemical binding]; other site 911045006690 phosphate binding motif [ion binding]; other site 911045006691 beta-alpha-beta structure motif; other site 911045006692 NAD(p) ribose binding residues [chemical binding]; other site 911045006693 NAD binding pocket [chemical binding]; other site 911045006694 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 911045006695 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045006696 catalytic loop [active] 911045006697 iron binding site [ion binding]; other site 911045006698 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 911045006699 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045006700 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 911045006701 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 911045006702 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 911045006703 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 911045006704 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 911045006705 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 911045006706 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 911045006707 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 911045006708 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 911045006709 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 911045006710 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 911045006711 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 911045006712 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 911045006713 Predicted transcriptional regulator [Transcription]; Region: COG4957 911045006714 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 911045006715 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 911045006716 DnaA box-binding interface [nucleotide binding]; other site 911045006717 Fe-S metabolism associated domain; Region: SufE; cl00951 911045006718 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 911045006719 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 911045006720 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 911045006721 Protein of unknown function (DUF1491); Region: DUF1491; cl11568 911045006722 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 911045006723 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 911045006724 Transglycosylase; Region: Transgly; cl07896 911045006725 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 911045006726 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045006727 Flagellin N-methylase; Region: FliB; cl00497 911045006728 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045006729 Uncharacterized conserved protein [Function unknown]; Region: COG5323 911045006730 Phage-related protein [Function unknown]; Region: COG4695; cl01923 911045006731 Phage portal protein; Region: Phage_portal; pfam04860 911045006732 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 911045006733 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 911045006734 Phage capsid family; Region: Phage_capsid; pfam05065 911045006735 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 911045006736 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 911045006737 oligomerization interface [polypeptide binding]; other site 911045006738 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 911045006739 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 911045006740 Phage major tail protein 2; Region: Phage_tail_2; cl11463 911045006741 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 911045006742 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; cl09774 911045006743 Phage-related minor tail protein [Function unknown]; Region: COG5281 911045006744 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 911045006745 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 911045006746 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 911045006747 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 911045006748 NlpC/P60 family; Region: NLPC_P60; cl11438 911045006749 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 911045006750 Putative phage tail protein; Region: Phage-tail_3; pfam13550 911045006751 Predicted membrane protein [Function unknown]; Region: COG3212 911045006752 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045006753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045006754 active site 911045006755 phosphorylation site [posttranslational modification] 911045006756 intermolecular recognition site; other site 911045006757 dimerization interface [polypeptide binding]; other site 911045006758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045006759 DNA binding site [nucleotide binding] 911045006760 sensor protein PhoQ; Provisional; Region: PRK10815 911045006761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045006762 ATP binding site [chemical binding]; other site 911045006763 Mg2+ binding site [ion binding]; other site 911045006764 G-X-G motif; other site 911045006765 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 911045006766 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 911045006767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045006768 binding surface 911045006769 TPR motif; other site 911045006770 CcmE; Region: CcmE; cl00994 911045006771 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 911045006772 Cytochrome C biogenesis protein; Region: CcmH; cl01179 911045006773 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 911045006774 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 911045006775 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 911045006776 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 911045006777 protein binding site [polypeptide binding]; other site 911045006778 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 911045006779 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 911045006780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045006781 active site 911045006782 phosphorylation site [posttranslational modification] 911045006783 intermolecular recognition site; other site 911045006784 dimerization interface [polypeptide binding]; other site 911045006785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045006786 DNA binding site [nucleotide binding] 911045006787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045006788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045006789 dimerization interface [polypeptide binding]; other site 911045006790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045006791 dimer interface [polypeptide binding]; other site 911045006792 phosphorylation site [posttranslational modification] 911045006793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045006794 ATP binding site [chemical binding]; other site 911045006795 Mg2+ binding site [ion binding]; other site 911045006796 G-X-G motif; other site 911045006797 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 911045006798 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 911045006799 metal binding triad; other site 911045006800 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 911045006801 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 911045006802 metal binding triad; other site 911045006803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045006804 PAS fold; Region: PAS_3; pfam08447 911045006805 putative active site [active] 911045006806 heme pocket [chemical binding]; other site 911045006807 sensory histidine kinase AtoS; Provisional; Region: PRK11360 911045006808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045006809 dimer interface [polypeptide binding]; other site 911045006810 phosphorylation site [posttranslational modification] 911045006811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045006812 ATP binding site [chemical binding]; other site 911045006813 Mg2+ binding site [ion binding]; other site 911045006814 G-X-G motif; other site 911045006815 aminopeptidase N; Provisional; Region: pepN; PRK14015 911045006816 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 911045006817 active site 911045006818 Zn binding site [ion binding]; other site 911045006819 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 911045006820 CoA-transferase family III; Region: CoA_transf_3; pfam02515 911045006821 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045006822 cyclase homology domain; Region: CHD; cd07302 911045006823 nucleotidyl binding site; other site 911045006824 metal binding site [ion binding]; metal-binding site 911045006825 dimer interface [polypeptide binding]; other site 911045006826 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 911045006827 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045006828 Walker A/P-loop; other site 911045006829 ATP binding site [chemical binding]; other site 911045006830 Q-loop/lid; other site 911045006831 ABC transporter signature motif; other site 911045006832 Walker B; other site 911045006833 D-loop; other site 911045006834 H-loop/switch region; other site 911045006835 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045006836 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045006837 Walker A/P-loop; other site 911045006838 ATP binding site [chemical binding]; other site 911045006839 Q-loop/lid; other site 911045006840 ABC transporter signature motif; other site 911045006841 Walker B; other site 911045006842 D-loop; other site 911045006843 H-loop/switch region; other site 911045006844 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045006845 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 911045006846 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045006847 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045006848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045006849 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 911045006850 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045006851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006852 dimer interface [polypeptide binding]; other site 911045006853 conserved gate region; other site 911045006854 putative PBP binding loops; other site 911045006855 ABC-ATPase subunit interface; other site 911045006856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045006857 S-adenosylmethionine binding site [chemical binding]; other site 911045006858 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 911045006859 NodB motif; other site 911045006860 putative active site [active] 911045006861 putative catalytic site [active] 911045006862 putative Zn binding site [ion binding]; other site 911045006863 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 911045006864 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 911045006865 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045006866 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 911045006867 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 911045006868 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 911045006869 putative ADP-binding pocket [chemical binding]; other site 911045006870 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 911045006871 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 911045006872 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045006873 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 911045006874 Walker A/P-loop; other site 911045006875 ATP binding site [chemical binding]; other site 911045006876 Q-loop/lid; other site 911045006877 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045006878 ABC transporter signature motif; other site 911045006879 Walker B; other site 911045006880 D-loop; other site 911045006881 H-loop/switch region; other site 911045006882 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045006883 ligand binding site [chemical binding]; other site 911045006884 flexible hinge region; other site 911045006885 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045006886 cyclase homology domain; Region: CHD; cd07302 911045006887 nucleotidyl binding site; other site 911045006888 metal binding site [ion binding]; metal-binding site 911045006889 dimer interface [polypeptide binding]; other site 911045006890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045006891 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 911045006892 NAD(P) binding site [chemical binding]; other site 911045006893 active site 911045006894 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045006895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045006896 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045006897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045006898 Dehydratase family; Region: ILVD_EDD; cl00340 911045006899 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 911045006900 putative peroxiredoxin; Provisional; Region: PRK13190 911045006901 decamer (pentamer of dimers) interface [polypeptide binding]; other site 911045006902 catalytic triad [active] 911045006903 dimer interface [polypeptide binding]; other site 911045006904 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 911045006905 putative hydrophobic ligand binding site [chemical binding]; other site 911045006906 CLM binding site; other site 911045006907 L1 loop; other site 911045006908 DNA binding site [nucleotide binding] 911045006909 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 911045006910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045006911 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 911045006912 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 911045006913 Walker A/P-loop; other site 911045006914 ATP binding site [chemical binding]; other site 911045006915 Q-loop/lid; other site 911045006916 ABC transporter signature motif; other site 911045006917 Walker B; other site 911045006918 D-loop; other site 911045006919 H-loop/switch region; other site 911045006920 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 911045006921 NMT1-like family; Region: NMT1_2; cl15260 911045006922 anthranilate synthase; Provisional; Region: PRK13566 911045006923 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 911045006924 chorismate binding enzyme; Region: Chorismate_bind; cl10555 911045006925 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 911045006926 glutamine binding [chemical binding]; other site 911045006927 catalytic triad [active] 911045006928 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 911045006929 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 911045006930 metal binding site [ion binding]; metal-binding site 911045006931 putative dimer interface [polypeptide binding]; other site 911045006932 fructokinase; Reviewed; Region: PRK09557 911045006933 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 911045006934 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 911045006935 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 911045006936 intersubunit interface [polypeptide binding]; other site 911045006937 active site 911045006938 Zn2+ binding site [ion binding]; other site 911045006939 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 911045006940 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045006941 Walker A/P-loop; other site 911045006942 ATP binding site [chemical binding]; other site 911045006943 Q-loop/lid; other site 911045006944 ABC transporter signature motif; other site 911045006945 Walker B; other site 911045006946 D-loop; other site 911045006947 H-loop/switch region; other site 911045006948 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045006949 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045006950 Walker A/P-loop; other site 911045006951 ATP binding site [chemical binding]; other site 911045006952 Q-loop/lid; other site 911045006953 ABC transporter signature motif; other site 911045006954 Walker B; other site 911045006955 D-loop; other site 911045006956 H-loop/switch region; other site 911045006957 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045006958 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 911045006959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006960 dimer interface [polypeptide binding]; other site 911045006961 conserved gate region; other site 911045006962 putative PBP binding loops; other site 911045006963 ABC-ATPase subunit interface; other site 911045006964 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045006965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006966 dimer interface [polypeptide binding]; other site 911045006967 conserved gate region; other site 911045006968 putative PBP binding loops; other site 911045006969 ABC-ATPase subunit interface; other site 911045006970 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 911045006971 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045006972 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 911045006973 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 911045006974 metal binding site [ion binding]; metal-binding site 911045006975 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 911045006976 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 911045006977 Substrate binding site; other site 911045006978 Cupin domain; Region: Cupin_2; cl09118 911045006979 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 911045006980 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 911045006981 active site 911045006982 substrate binding site [chemical binding]; other site 911045006983 metal binding site [ion binding]; metal-binding site 911045006984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045006985 Helix-turn-helix domains; Region: HTH; cl00088 911045006986 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045006987 dimerization interface [polypeptide binding]; other site 911045006988 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 911045006989 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045006990 tetrameric interface [polypeptide binding]; other site 911045006991 NAD binding site [chemical binding]; other site 911045006992 catalytic residues [active] 911045006993 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 911045006994 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045006995 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045006996 Walker A/P-loop; other site 911045006997 ATP binding site [chemical binding]; other site 911045006998 Q-loop/lid; other site 911045006999 ABC transporter signature motif; other site 911045007000 Walker B; other site 911045007001 D-loop; other site 911045007002 H-loop/switch region; other site 911045007003 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 911045007004 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 911045007005 Walker A/P-loop; other site 911045007006 ATP binding site [chemical binding]; other site 911045007007 Q-loop/lid; other site 911045007008 Walker B; other site 911045007009 D-loop; other site 911045007010 H-loop/switch region; other site 911045007011 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 911045007012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045007013 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 911045007014 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 911045007015 Helix-turn-helix domains; Region: HTH; cl00088 911045007016 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 911045007017 intersubunit interface [polypeptide binding]; other site 911045007018 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 911045007019 metal binding site [ion binding]; metal-binding site 911045007020 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045007021 Helix-turn-helix domains; Region: HTH; cl00088 911045007022 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045007023 EamA-like transporter family; Region: EamA; cl01037 911045007024 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 911045007025 Cupin domain; Region: Cupin_2; cl09118 911045007026 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 911045007027 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045007028 dimerization interface [polypeptide binding]; other site 911045007029 putative DNA binding site [nucleotide binding]; other site 911045007030 putative Zn2+ binding site [ion binding]; other site 911045007031 FG-GAP repeat; Region: FG-GAP; cl15299 911045007032 FG-GAP repeat; Region: FG-GAP; cl15299 911045007033 FG-GAP repeat; Region: FG-GAP; cl15299 911045007034 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 911045007035 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045007036 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 911045007037 Sel1 repeat; Region: Sel1; cl02723 911045007038 Sel1 repeat; Region: Sel1; cl02723 911045007039 Sel1 repeat; Region: Sel1; cl02723 911045007040 Sel1 repeat; Region: Sel1; cl02723 911045007041 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 911045007042 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 911045007043 FMN binding site [chemical binding]; other site 911045007044 active site 911045007045 catalytic residues [active] 911045007046 substrate binding site [chemical binding]; other site 911045007047 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045007048 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 911045007049 Predicted aspartyl protease [General function prediction only]; Region: COG3577 911045007050 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 911045007051 catalytic motif [active] 911045007052 Catalytic residue [active] 911045007053 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 911045007054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 911045007055 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 911045007056 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 911045007057 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 911045007058 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 911045007059 putative dimer interface [polypeptide binding]; other site 911045007060 active site pocket [active] 911045007061 putative cataytic base [active] 911045007062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045007063 dimer interface [polypeptide binding]; other site 911045007064 phosphorylation site [posttranslational modification] 911045007065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045007066 ATP binding site [chemical binding]; other site 911045007067 Mg2+ binding site [ion binding]; other site 911045007068 G-X-G motif; other site 911045007069 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045007070 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 911045007071 putative N-terminal domain interface [polypeptide binding]; other site 911045007072 putative dimer interface [polypeptide binding]; other site 911045007073 putative substrate binding pocket (H-site) [chemical binding]; other site 911045007074 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 911045007075 ligand binding site [chemical binding]; other site 911045007076 active site 911045007077 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045007078 Helix-turn-helix domains; Region: HTH; cl00088 911045007079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045007080 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 911045007081 NAD(P) binding pocket [chemical binding]; other site 911045007082 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 911045007083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007084 dimer interface [polypeptide binding]; other site 911045007085 conserved gate region; other site 911045007086 putative PBP binding loops; other site 911045007087 ABC-ATPase subunit interface; other site 911045007088 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 911045007089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045007090 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 911045007091 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045007092 substrate binding pocket [chemical binding]; other site 911045007093 membrane-bound complex binding site; other site 911045007094 hinge residues; other site 911045007095 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045007096 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045007097 substrate binding pocket [chemical binding]; other site 911045007098 membrane-bound complex binding site; other site 911045007099 hinge residues; other site 911045007100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045007101 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045007102 substrate binding pocket [chemical binding]; other site 911045007103 membrane-bound complex binding site; other site 911045007104 hinge residues; other site 911045007105 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 911045007106 dimer interface [polypeptide binding]; other site 911045007107 putative functional site; other site 911045007108 putative MPT binding site; other site 911045007109 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 911045007110 GTP binding site; other site 911045007111 Sensors of blue-light using FAD; Region: BLUF; cl04855 911045007112 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 911045007113 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 911045007114 active site 911045007115 metal binding site [ion binding]; metal-binding site 911045007116 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 911045007117 Domain of unknown function DUF59; Region: DUF59; cl00941 911045007118 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 911045007119 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 911045007120 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045007121 Helix-turn-helix domains; Region: HTH; cl00088 911045007122 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 911045007123 dimerization interface [polypeptide binding]; other site 911045007124 substrate binding pocket [chemical binding]; other site 911045007125 Flp/Fap pilin component; Region: Flp_Fap; cl01585 911045007126 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 911045007127 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045007128 FeS/SAM binding site; other site 911045007129 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 911045007130 Protein of unknown function (DUF971); Region: DUF971; cl01414 911045007131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 911045007132 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 911045007133 fumarate hydratase; Provisional; Region: PRK15389 911045007134 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 911045007135 Fumarase C-terminus; Region: Fumerase_C; cl00795 911045007136 YceI-like domain; Region: YceI; cl01001 911045007137 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 911045007138 YceI-like domain; Region: YceI; cl01001 911045007139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045007140 S-adenosylmethionine binding site [chemical binding]; other site 911045007141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045007142 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045007143 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045007144 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 911045007145 tetramerization interface [polypeptide binding]; other site 911045007146 NAD(P) binding site [chemical binding]; other site 911045007147 catalytic residues [active] 911045007148 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 911045007149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 911045007150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 911045007151 Family of unknown function (DUF490); Region: DUF490; pfam04357 911045007152 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 911045007153 Surface antigen; Region: Bac_surface_Ag; cl03097 911045007154 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 911045007155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045007156 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 911045007157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045007158 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045007159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045007160 active site 911045007161 phosphorylation site [posttranslational modification] 911045007162 intermolecular recognition site; other site 911045007163 dimerization interface [polypeptide binding]; other site 911045007164 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045007165 DNA binding site [nucleotide binding] 911045007166 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 911045007167 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045007168 Walker A motif; other site 911045007169 ATP binding site [chemical binding]; other site 911045007170 Walker B motif; other site 911045007171 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 911045007172 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 911045007173 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 911045007174 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 911045007175 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 911045007176 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 911045007177 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 911045007178 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 911045007179 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 911045007180 FliG C-terminal domain; Region: FliG_C; pfam01706 911045007181 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK13109 911045007182 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 911045007183 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 911045007184 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 911045007185 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 911045007186 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 911045007187 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 911045007188 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 911045007189 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 911045007190 SAF domain; Region: SAF; cl00555 911045007191 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 911045007192 Flagellar P-ring protein; Region: FlgI; pfam02119 911045007193 MgtE intracellular N domain; Region: MgtE_N; cl15244 911045007194 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 911045007195 Flagellar L-ring protein; Region: FlgH; cl00905 911045007196 FliP family; Region: FliP; cl00593 911045007197 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 911045007198 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 911045007199 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 911045007200 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 911045007201 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 911045007202 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 911045007203 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 911045007204 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 911045007205 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 911045007206 flagellar motor protein MotB; Validated; Region: motB; PRK05996 911045007207 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 911045007208 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 911045007209 ligand binding site [chemical binding]; other site 911045007210 chemotaxis protein; Reviewed; Region: PRK12798 911045007211 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 911045007212 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 911045007213 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 911045007214 N-acetyl-D-glucosamine binding site [chemical binding]; other site 911045007215 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 911045007216 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 911045007217 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 911045007218 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 911045007219 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 911045007220 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 911045007221 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 911045007222 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 911045007223 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 911045007224 Flagellar protein FlaF; Region: FlaF; cl11454 911045007225 Flagellar protein FlbT; Region: FlbT; cl11455 911045007226 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 911045007227 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 911045007228 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 911045007229 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 911045007230 FHIPEP family; Region: FHIPEP; pfam00771 911045007231 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 911045007232 Rod binding protein; Region: Rod-binding; cl01626 911045007233 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 911045007234 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045007235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045007236 DNA-binding site [nucleotide binding]; DNA binding site 911045007237 FCD domain; Region: FCD; cl11656 911045007238 SlyX; Region: SlyX; cl01090 911045007239 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 911045007240 DNA binding residues [nucleotide binding] 911045007241 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 911045007242 putative dimer interface [polypeptide binding]; other site 911045007243 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 911045007244 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 911045007245 peptide binding site [polypeptide binding]; other site 911045007246 dipeptide transporter permease DppB; Provisional; Region: PRK10914 911045007247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007248 dimer interface [polypeptide binding]; other site 911045007249 conserved gate region; other site 911045007250 putative PBP binding loops; other site 911045007251 ABC-ATPase subunit interface; other site 911045007252 dipeptide transporter; Provisional; Region: PRK10913 911045007253 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045007254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007255 putative PBP binding loops; other site 911045007256 dimer interface [polypeptide binding]; other site 911045007257 ABC-ATPase subunit interface; other site 911045007258 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045007259 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 911045007260 Walker A/P-loop; other site 911045007261 ATP binding site [chemical binding]; other site 911045007262 Q-loop/lid; other site 911045007263 ABC transporter signature motif; other site 911045007264 Walker B; other site 911045007265 D-loop; other site 911045007266 H-loop/switch region; other site 911045007267 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045007268 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045007269 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 911045007270 Walker A/P-loop; other site 911045007271 ATP binding site [chemical binding]; other site 911045007272 Q-loop/lid; other site 911045007273 ABC transporter signature motif; other site 911045007274 Walker B; other site 911045007275 D-loop; other site 911045007276 H-loop/switch region; other site 911045007277 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045007278 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 911045007279 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 911045007280 peptide binding site [polypeptide binding]; other site 911045007281 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 911045007282 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 911045007283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045007284 catalytic residue [active] 911045007285 putative MFS family transporter protein; Provisional; Region: PRK03633 911045007286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045007287 putative substrate translocation pore; other site 911045007288 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 911045007289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045007290 motif II; other site 911045007291 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 911045007292 tetramer (dimer of dimers) interface [polypeptide binding]; other site 911045007293 active site 911045007294 dimer interface [polypeptide binding]; other site 911045007295 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 911045007296 glutathione reductase; Validated; Region: PRK06116 911045007297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 911045007298 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 911045007299 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 911045007300 putative active site pocket [active] 911045007301 dimerization interface [polypeptide binding]; other site 911045007302 putative catalytic residue [active] 911045007303 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 911045007304 Response regulator receiver domain; Region: Response_reg; pfam00072 911045007305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045007306 active site 911045007307 phosphorylation site [posttranslational modification] 911045007308 intermolecular recognition site; other site 911045007309 dimerization interface [polypeptide binding]; other site 911045007310 NAD synthetase; Provisional; Region: PRK13981 911045007311 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 911045007312 multimer interface [polypeptide binding]; other site 911045007313 active site 911045007314 catalytic triad [active] 911045007315 protein interface 1 [polypeptide binding]; other site 911045007316 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 911045007317 homodimer interface [polypeptide binding]; other site 911045007318 NAD binding pocket [chemical binding]; other site 911045007319 ATP binding pocket [chemical binding]; other site 911045007320 Mg binding site [ion binding]; other site 911045007321 active-site loop [active] 911045007322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045007323 putative substrate translocation pore; other site 911045007324 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045007325 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 911045007326 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 911045007327 active site 911045007328 HIGH motif; other site 911045007329 nucleotide binding site [chemical binding]; other site 911045007330 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 911045007331 active site 911045007332 KMSKS motif; other site 911045007333 hypothetical protein; Provisional; Region: PRK10756 911045007334 CreA protein; Region: CreA; pfam05981 911045007335 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045007336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 911045007337 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 911045007338 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 911045007339 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 911045007340 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 911045007341 active site 911045007342 HIGH motif; other site 911045007343 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 911045007344 KMSKS motif; other site 911045007345 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 911045007346 tRNA binding surface [nucleotide binding]; other site 911045007347 anticodon binding site; other site 911045007348 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 911045007349 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 911045007350 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 911045007351 active site 911045007352 catalytic residues [active] 911045007353 metal binding site [ion binding]; metal-binding site 911045007354 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 911045007355 Predicted permeases [General function prediction only]; Region: RarD; COG2962 911045007356 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 911045007357 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 911045007358 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045007359 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 911045007360 ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253 911045007361 Walker A/P-loop; other site 911045007362 ATP binding site [chemical binding]; other site 911045007363 Q-loop/lid; other site 911045007364 ABC transporter signature motif; other site 911045007365 Walker B; other site 911045007366 D-loop; other site 911045007367 H-loop/switch region; other site 911045007368 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 911045007369 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 911045007370 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 911045007371 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 911045007372 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 911045007373 Protein export membrane protein; Region: SecD_SecF; cl14618 911045007374 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045007375 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045007376 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045007377 Helix-turn-helix domains; Region: HTH; cl00088 911045007378 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 911045007379 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 911045007380 active site 911045007381 catalytic site [active] 911045007382 tetramer interface [polypeptide binding]; other site 911045007383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 911045007384 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 911045007385 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045007386 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045007387 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045007388 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 911045007389 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 911045007390 active site 911045007391 tetramer interface [polypeptide binding]; other site 911045007392 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 911045007393 active site 911045007394 Zn binding site [ion binding]; other site 911045007395 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 911045007396 NADP binding site [chemical binding]; other site 911045007397 homodimer interface [polypeptide binding]; other site 911045007398 active site 911045007399 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 911045007400 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 911045007401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 911045007402 putative transporter; Provisional; Region: PRK10504 911045007403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045007404 putative substrate translocation pore; other site 911045007405 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 911045007406 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 911045007407 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 911045007408 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 911045007409 active site 911045007410 Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; cl01566 911045007411 Predicted acetyltransferase [General function prediction only]; Region: COG3153 911045007412 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045007413 Cache domain; Region: Cache_1; pfam02743 911045007414 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045007415 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045007416 dimer interface [polypeptide binding]; other site 911045007417 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 911045007418 putative CheW interface [polypeptide binding]; other site 911045007419 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 911045007420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 911045007421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045007422 binding surface 911045007423 TPR motif; other site 911045007424 TPR repeat; Region: TPR_11; pfam13414 911045007425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045007426 TPR motif; other site 911045007427 binding surface 911045007428 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045007429 Helix-turn-helix domains; Region: HTH; cl00088 911045007430 GMP synthase; Reviewed; Region: guaA; PRK00074 911045007431 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 911045007432 AMP/PPi binding site [chemical binding]; other site 911045007433 candidate oxyanion hole; other site 911045007434 catalytic triad [active] 911045007435 potential glutamine specificity residues [chemical binding]; other site 911045007436 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 911045007437 ATP Binding subdomain [chemical binding]; other site 911045007438 Ligand Binding sites [chemical binding]; other site 911045007439 Dimerization subdomain; other site 911045007440 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 911045007441 PilZ domain; Region: PilZ; cl01260 911045007442 Phospholipid methyltransferase; Region: PEMT; cl00763 911045007443 Phospholipid methyltransferase; Region: PEMT; cl00763 911045007444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 911045007445 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 911045007446 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 911045007447 Trp docking motif [polypeptide binding]; other site 911045007448 active site 911045007449 PQQ-like domain; Region: PQQ_2; pfam13360 911045007450 GTP-binding protein Der; Reviewed; Region: PRK00093 911045007451 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 911045007452 G1 box; other site 911045007453 GTP/Mg2+ binding site [chemical binding]; other site 911045007454 Switch I region; other site 911045007455 G2 box; other site 911045007456 Switch II region; other site 911045007457 G3 box; other site 911045007458 G4 box; other site 911045007459 G5 box; other site 911045007460 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 911045007461 G1 box; other site 911045007462 GTP/Mg2+ binding site [chemical binding]; other site 911045007463 Switch I region; other site 911045007464 G2 box; other site 911045007465 G3 box; other site 911045007466 Switch II region; other site 911045007467 G4 box; other site 911045007468 G5 box; other site 911045007469 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 911045007470 active site 911045007471 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 911045007472 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 911045007473 classical (c) SDRs; Region: SDR_c; cd05233 911045007474 NAD(P) binding site [chemical binding]; other site 911045007475 active site 911045007476 amidophosphoribosyltransferase; Provisional; Region: PRK09123 911045007477 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 911045007478 active site 911045007479 tetramer interface [polypeptide binding]; other site 911045007480 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045007481 active site 911045007482 Colicin V production protein; Region: Colicin_V; cl00567 911045007483 DNA repair protein RadA; Provisional; Region: PRK11823 911045007484 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045007485 Walker A motif; other site 911045007486 ATP binding site [chemical binding]; other site 911045007487 Walker B motif; other site 911045007488 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 911045007489 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 911045007490 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 911045007491 active site 911045007492 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045007493 dimer interface [polypeptide binding]; other site 911045007494 substrate binding site [chemical binding]; other site 911045007495 catalytic residues [active] 911045007496 replicative DNA helicase; Provisional; Region: PRK09165 911045007497 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 911045007498 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 911045007499 Walker A motif; other site 911045007500 ATP binding site [chemical binding]; other site 911045007501 Walker B motif; other site 911045007502 DNA binding loops [nucleotide binding] 911045007503 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 911045007504 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 911045007505 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 911045007506 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 911045007507 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 911045007508 Acyl transferase domain; Region: Acyl_transf_1; cl08282 911045007509 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 911045007510 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 911045007511 NAD(P) binding site [chemical binding]; other site 911045007512 homotetramer interface [polypeptide binding]; other site 911045007513 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 911045007514 homodimer interface [polypeptide binding]; other site 911045007515 active site 911045007516 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045007517 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 911045007518 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 911045007519 dimer interface [polypeptide binding]; other site 911045007520 active site 911045007521 YceG-like family; Region: YceG; pfam02618 911045007522 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 911045007523 dimerization interface [polypeptide binding]; other site 911045007524 hypothetical protein; Provisional; Region: PRK11820 911045007525 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 911045007526 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 911045007527 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 911045007528 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 911045007529 catalytic site [active] 911045007530 G-X2-G-X-G-K; other site 911045007531 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 911045007532 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045007533 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045007534 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045007535 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 911045007536 putative active site [active] 911045007537 catalytic triad [active] 911045007538 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 911045007539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045007540 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 911045007541 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 911045007542 SurA N-terminal domain; Region: SurA_N_3; cl07813 911045007543 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 911045007544 OstA-like protein; Region: OstA; cl00844 911045007545 Organic solvent tolerance protein; Region: OstA_C; pfam04453 911045007546 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 911045007547 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 911045007548 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 911045007549 multifunctional aminopeptidase A; Provisional; Region: PRK00913 911045007550 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 911045007551 interface (dimer of trimers) [polypeptide binding]; other site 911045007552 Substrate-binding/catalytic site; other site 911045007553 Zn-binding sites [ion binding]; other site 911045007554 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 911045007555 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 911045007556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045007557 S-adenosylmethionine binding site [chemical binding]; other site 911045007558 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 911045007559 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045007560 Walker A/P-loop; other site 911045007561 ATP binding site [chemical binding]; other site 911045007562 Q-loop/lid; other site 911045007563 ABC transporter signature motif; other site 911045007564 Walker B; other site 911045007565 D-loop; other site 911045007566 H-loop/switch region; other site 911045007567 ABC transporter; Region: ABC_tran_2; pfam12848 911045007568 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 911045007569 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045007570 EamA-like transporter family; Region: EamA; cl01037 911045007571 EamA-like transporter family; Region: EamA; cl01037 911045007572 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 911045007573 synthetase active site [active] 911045007574 NTP binding site [chemical binding]; other site 911045007575 metal binding site [ion binding]; metal-binding site 911045007576 Protein of unknown function (DUF419); Region: DUF419; cl15265 911045007577 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045007578 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 911045007579 DinB superfamily; Region: DinB_2; pfam12867 911045007580 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 911045007581 active site 911045007582 multimer interface [polypeptide binding]; other site 911045007583 Domain of unknown function (DUF336); Region: DUF336; cl01249 911045007584 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 911045007585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007586 Helix-turn-helix domains; Region: HTH; cl00088 911045007587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007588 Helix-turn-helix domains; Region: HTH; cl00088 911045007589 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 911045007590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007591 Helix-turn-helix domains; Region: HTH; cl00088 911045007592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007593 Helix-turn-helix domains; Region: HTH; cl00088 911045007594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007595 Helix-turn-helix domains; Region: HTH; cl00088 911045007596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007597 Helix-turn-helix domains; Region: HTH; cl00088 911045007598 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045007599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007600 Helix-turn-helix domains; Region: HTH; cl00088 911045007601 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 911045007602 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045007603 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 911045007604 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 911045007605 putative [4Fe-4S] binding site [ion binding]; other site 911045007606 putative molybdopterin cofactor binding site [chemical binding]; other site 911045007607 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 911045007608 putative molybdopterin cofactor binding site; other site 911045007609 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 911045007610 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 911045007611 active site 911045007612 substrate binding site [chemical binding]; other site 911045007613 cosubstrate binding site; other site 911045007614 catalytic site [active] 911045007615 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 911045007616 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 911045007617 dimerization interface [polypeptide binding]; other site 911045007618 putative ATP binding site [chemical binding]; other site 911045007619 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 911045007620 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 911045007621 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045007622 polyphosphate kinase; Provisional; Region: PRK05443 911045007623 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 911045007624 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 911045007625 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 911045007626 putative domain interface [polypeptide binding]; other site 911045007627 putative active site [active] 911045007628 catalytic site [active] 911045007629 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 911045007630 putative domain interface [polypeptide binding]; other site 911045007631 putative active site [active] 911045007632 catalytic site [active] 911045007633 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 911045007634 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 911045007635 ribonuclease D; Region: rnd; TIGR01388 911045007636 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 911045007637 putative active site [active] 911045007638 catalytic site [active] 911045007639 putative substrate binding site [chemical binding]; other site 911045007640 HRDC domain; Region: HRDC; cl02578 911045007641 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 911045007642 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 911045007643 dimer interface [polypeptide binding]; other site 911045007644 anticodon binding site; other site 911045007645 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 911045007646 homodimer interface [polypeptide binding]; other site 911045007647 motif 1; other site 911045007648 active site 911045007649 motif 2; other site 911045007650 GAD domain; Region: GAD; pfam02938 911045007651 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 911045007652 active site 911045007653 motif 3; other site 911045007654 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 911045007655 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045007656 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 911045007657 Walker A/P-loop; other site 911045007658 ATP binding site [chemical binding]; other site 911045007659 Q-loop/lid; other site 911045007660 ABC transporter signature motif; other site 911045007661 Walker B; other site 911045007662 D-loop; other site 911045007663 H-loop/switch region; other site 911045007664 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 911045007665 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045007666 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 911045007667 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 911045007668 FAD binding pocket [chemical binding]; other site 911045007669 FAD binding motif [chemical binding]; other site 911045007670 phosphate binding motif [ion binding]; other site 911045007671 beta-alpha-beta structure motif; other site 911045007672 NAD binding pocket [chemical binding]; other site 911045007673 RecX family; Region: RecX; cl00936 911045007674 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 911045007675 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 911045007676 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 911045007677 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 911045007678 Potassium binding sites [ion binding]; other site 911045007679 Cesium cation binding sites [ion binding]; other site 911045007680 EamA-like transporter family; Region: EamA; cl01037 911045007681 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 911045007682 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045007683 N-terminal plug; other site 911045007684 ligand-binding site [chemical binding]; other site 911045007685 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 911045007686 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 911045007687 intersubunit interface [polypeptide binding]; other site 911045007688 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 911045007689 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 911045007690 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045007691 ABC-ATPase subunit interface; other site 911045007692 dimer interface [polypeptide binding]; other site 911045007693 putative PBP binding regions; other site 911045007694 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 911045007695 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 911045007696 Walker A/P-loop; other site 911045007697 ATP binding site [chemical binding]; other site 911045007698 Q-loop/lid; other site 911045007699 ABC transporter signature motif; other site 911045007700 Walker B; other site 911045007701 D-loop; other site 911045007702 H-loop/switch region; other site 911045007703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007704 Helix-turn-helix domains; Region: HTH; cl00088 911045007705 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 911045007706 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 911045007707 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 911045007708 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 911045007709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045007710 NAD(P) binding pocket [chemical binding]; other site 911045007711 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 911045007712 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 911045007713 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045007714 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 911045007715 phosphate binding site [ion binding]; other site 911045007716 dimer interface [polypeptide binding]; other site 911045007717 substrate binding site [chemical binding]; other site 911045007718 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Region: F420_cofH; TIGR03551 911045007719 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045007720 FeS/SAM binding site; other site 911045007721 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045007722 FeS/SAM binding site; other site 911045007723 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 911045007724 allantoate amidohydrolase; Reviewed; Region: PRK09290 911045007725 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 911045007726 active site 911045007727 metal binding site [ion binding]; metal-binding site 911045007728 dimer interface [polypeptide binding]; other site 911045007729 phenylhydantoinase; Validated; Region: PRK08323 911045007730 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 911045007731 tetramer interface [polypeptide binding]; other site 911045007732 active site 911045007733 Sodium:solute symporter family; Region: SSF; cl00456 911045007734 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 911045007735 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 911045007736 AMP-binding enzyme; Region: AMP-binding; cl15778 911045007737 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045007738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007739 Helix-turn-helix domains; Region: HTH; cl00088 911045007740 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045007741 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045007742 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045007743 DctM-like transporters; Region: DctM; pfam06808 911045007744 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045007745 amidase; Provisional; Region: PRK07487 911045007746 Amidase; Region: Amidase; cl11426 911045007747 alpha-galactosidase; Provisional; Region: PRK15076 911045007748 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 911045007749 NAD binding site [chemical binding]; other site 911045007750 sugar binding site [chemical binding]; other site 911045007751 divalent metal binding site [ion binding]; other site 911045007752 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 911045007753 dimer interface [polypeptide binding]; other site 911045007754 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 911045007755 classical (c) SDRs; Region: SDR_c; cd05233 911045007756 NAD(P) binding site [chemical binding]; other site 911045007757 active site 911045007758 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 911045007759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045007760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045007761 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045007762 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045007763 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045007764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007765 dimer interface [polypeptide binding]; other site 911045007766 conserved gate region; other site 911045007767 putative PBP binding loops; other site 911045007768 ABC-ATPase subunit interface; other site 911045007769 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045007770 dipeptide transporter; Provisional; Region: PRK10913 911045007771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007772 dimer interface [polypeptide binding]; other site 911045007773 conserved gate region; other site 911045007774 putative PBP binding loops; other site 911045007775 ABC-ATPase subunit interface; other site 911045007776 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 911045007777 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045007778 Walker A/P-loop; other site 911045007779 ATP binding site [chemical binding]; other site 911045007780 Q-loop/lid; other site 911045007781 ABC transporter signature motif; other site 911045007782 Walker B; other site 911045007783 D-loop; other site 911045007784 H-loop/switch region; other site 911045007785 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045007786 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045007787 Walker A/P-loop; other site 911045007788 ATP binding site [chemical binding]; other site 911045007789 Q-loop/lid; other site 911045007790 ABC transporter signature motif; other site 911045007791 Walker B; other site 911045007792 D-loop; other site 911045007793 H-loop/switch region; other site 911045007794 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 911045007795 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 911045007796 dimer interface [polypeptide binding]; other site 911045007797 Alkaline phosphatase homologues; Region: alkPPc; smart00098 911045007798 active site 911045007799 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 911045007800 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045007801 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045007802 DNA binding site [nucleotide binding] 911045007803 domain linker motif; other site 911045007804 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 911045007805 ligand binding site [chemical binding]; other site 911045007806 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045007807 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045007808 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045007809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007810 dimer interface [polypeptide binding]; other site 911045007811 conserved gate region; other site 911045007812 putative PBP binding loops; other site 911045007813 ABC-ATPase subunit interface; other site 911045007814 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045007815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007816 dimer interface [polypeptide binding]; other site 911045007817 conserved gate region; other site 911045007818 putative PBP binding loops; other site 911045007819 ABC-ATPase subunit interface; other site 911045007820 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045007821 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045007822 Walker A/P-loop; other site 911045007823 ATP binding site [chemical binding]; other site 911045007824 Q-loop/lid; other site 911045007825 ABC transporter signature motif; other site 911045007826 Walker B; other site 911045007827 D-loop; other site 911045007828 H-loop/switch region; other site 911045007829 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045007830 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 911045007831 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 911045007832 DNA binding residues [nucleotide binding] 911045007833 dimer interface [polypeptide binding]; other site 911045007834 [2Fe-2S] cluster binding site [ion binding]; other site 911045007835 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045007836 classical (c) SDRs; Region: SDR_c; cd05233 911045007837 NAD(P) binding site [chemical binding]; other site 911045007838 active site 911045007839 Putative cyclase; Region: Cyclase; cl00814 911045007840 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 911045007841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045007842 NAD(P) binding site [chemical binding]; other site 911045007843 active site 911045007844 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 911045007845 lipid-transfer protein; Provisional; Region: PRK07855 911045007846 active site 911045007847 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 911045007848 AMP-binding enzyme; Region: AMP-binding; cl15778 911045007849 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 911045007850 inter-subunit interface; other site 911045007851 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 911045007852 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 911045007853 iron-sulfur cluster [ion binding]; other site 911045007854 [2Fe-2S] cluster binding site [ion binding]; other site 911045007855 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 911045007856 putative alpha subunit interface [polypeptide binding]; other site 911045007857 putative active site [active] 911045007858 putative substrate binding site [chemical binding]; other site 911045007859 Fe binding site [ion binding]; other site 911045007860 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 911045007861 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 911045007862 FMN-binding pocket [chemical binding]; other site 911045007863 flavin binding motif; other site 911045007864 phosphate binding motif [ion binding]; other site 911045007865 beta-alpha-beta structure motif; other site 911045007866 NAD binding pocket [chemical binding]; other site 911045007867 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045007868 catalytic loop [active] 911045007869 iron binding site [ion binding]; other site 911045007870 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045007871 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045007872 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045007873 DctM-like transporters; Region: DctM; pfam06808 911045007874 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045007875 Helix-turn-helix domains; Region: HTH; cl00088 911045007876 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045007877 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045007878 Helix-turn-helix domains; Region: HTH; cl00088 911045007879 Helix-turn-helix domains; Region: HTH; cl00088 911045007880 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 911045007881 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 911045007882 dimer interface [polypeptide binding]; other site 911045007883 PYR/PP interface [polypeptide binding]; other site 911045007884 TPP binding site [chemical binding]; other site 911045007885 substrate binding site [chemical binding]; other site 911045007886 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 911045007887 TPP-binding site; other site 911045007888 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 911045007889 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 911045007890 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 911045007891 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 911045007892 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 911045007893 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 911045007894 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 911045007895 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045007896 putative catalytic site [active] 911045007897 putative metal binding site [ion binding]; other site 911045007898 putative phosphate binding site [ion binding]; other site 911045007899 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 911045007900 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 911045007901 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 911045007902 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 911045007903 hypothetical protein; Provisional; Region: PRK07033 911045007904 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 911045007905 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 911045007906 ligand binding site [chemical binding]; other site 911045007907 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 911045007908 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 911045007909 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 911045007910 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 911045007911 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 911045007912 phosphopeptide binding site; other site 911045007913 PAAR motif; Region: PAAR_motif; cl15808 911045007914 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 911045007915 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 911045007916 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 911045007917 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 911045007918 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 911045007919 Ion transport protein; Region: Ion_trans; pfam00520 911045007920 Polycystin cation channel; Region: PKD_channel; pfam08016 911045007921 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 911045007922 Clp amino terminal domain; Region: Clp_N; pfam02861 911045007923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045007924 Walker A motif; other site 911045007925 ATP binding site [chemical binding]; other site 911045007926 Walker B motif; other site 911045007927 arginine finger; other site 911045007928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045007929 Walker A motif; other site 911045007930 ATP binding site [chemical binding]; other site 911045007931 Walker B motif; other site 911045007932 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 911045007933 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 911045007934 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 911045007935 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 911045007936 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 911045007937 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 911045007938 ImpE protein; Region: ImpE; pfam07024 911045007939 Protein of unknown function (DUF796); Region: DUF796; cl01226 911045007940 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 911045007941 Protein of unknown function (DUF877); Region: DUF877; pfam05943 911045007942 Protein of unknown function (DUF770); Region: DUF770; cl01402 911045007943 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 911045007944 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 911045007945 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 911045007946 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045007947 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045007948 DNA binding site [nucleotide binding] 911045007949 domain linker motif; other site 911045007950 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 911045007951 ligand binding site [chemical binding]; other site 911045007952 dimerization interface [polypeptide binding]; other site 911045007953 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045007954 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045007955 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 911045007956 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045007957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007958 dimer interface [polypeptide binding]; other site 911045007959 conserved gate region; other site 911045007960 putative PBP binding loops; other site 911045007961 ABC-ATPase subunit interface; other site 911045007962 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045007963 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 911045007964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007965 dimer interface [polypeptide binding]; other site 911045007966 conserved gate region; other site 911045007967 putative PBP binding loops; other site 911045007968 ABC-ATPase subunit interface; other site 911045007969 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 911045007970 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045007971 Walker A/P-loop; other site 911045007972 ATP binding site [chemical binding]; other site 911045007973 Q-loop/lid; other site 911045007974 ABC transporter signature motif; other site 911045007975 Walker B; other site 911045007976 D-loop; other site 911045007977 H-loop/switch region; other site 911045007978 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045007979 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 911045007980 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045007981 Walker A/P-loop; other site 911045007982 ATP binding site [chemical binding]; other site 911045007983 Q-loop/lid; other site 911045007984 ABC transporter signature motif; other site 911045007985 Walker B; other site 911045007986 D-loop; other site 911045007987 H-loop/switch region; other site 911045007988 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045007989 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 911045007990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045007991 active site 911045007992 motif I; other site 911045007993 motif II; other site 911045007994 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 911045007995 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 911045007996 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 911045007997 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 911045007998 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 911045007999 NADP binding site [chemical binding]; other site 911045008000 homodimer interface [polypeptide binding]; other site 911045008001 active site 911045008002 KduI/IolB family; Region: KduI; cl01508 911045008003 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 911045008004 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 911045008005 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 911045008006 Walker A/P-loop; other site 911045008007 ATP binding site [chemical binding]; other site 911045008008 Q-loop/lid; other site 911045008009 ABC transporter signature motif; other site 911045008010 Walker B; other site 911045008011 D-loop; other site 911045008012 H-loop/switch region; other site 911045008013 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 911045008014 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 911045008015 TM-ABC transporter signature motif; other site 911045008016 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 911045008017 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 911045008018 ligand binding site [chemical binding]; other site 911045008019 dimerization interface [polypeptide binding]; other site 911045008020 transcriptional repressor RbsR; Provisional; Region: PRK10423 911045008021 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045008022 DNA binding site [nucleotide binding] 911045008023 domain linker motif; other site 911045008024 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045008025 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045008026 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 911045008027 substrate binding site [chemical binding]; other site 911045008028 dimer interface [polypeptide binding]; other site 911045008029 ATP binding site [chemical binding]; other site 911045008030 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 911045008031 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 911045008032 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 911045008033 active site 911045008034 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 911045008035 Ligand Binding Site [chemical binding]; other site 911045008036 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 911045008037 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 911045008038 putative NAD(P) binding site [chemical binding]; other site 911045008039 putative substrate binding site [chemical binding]; other site 911045008040 catalytic Zn binding site [ion binding]; other site 911045008041 structural Zn binding site [ion binding]; other site 911045008042 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 911045008043 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 911045008044 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 911045008045 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 911045008046 FAD binding pocket [chemical binding]; other site 911045008047 FAD binding motif [chemical binding]; other site 911045008048 phosphate binding motif [ion binding]; other site 911045008049 beta-alpha-beta structure motif; other site 911045008050 NAD binding pocket [chemical binding]; other site 911045008051 sensor protein QseC; Provisional; Region: PRK10337 911045008052 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045008053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045008054 dimer interface [polypeptide binding]; other site 911045008055 phosphorylation site [posttranslational modification] 911045008056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045008057 ATP binding site [chemical binding]; other site 911045008058 Mg2+ binding site [ion binding]; other site 911045008059 G-X-G motif; other site 911045008060 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 911045008061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045008062 active site 911045008063 phosphorylation site [posttranslational modification] 911045008064 intermolecular recognition site; other site 911045008065 dimerization interface [polypeptide binding]; other site 911045008066 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045008067 DNA binding site [nucleotide binding] 911045008068 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 911045008069 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 911045008070 NADP binding site [chemical binding]; other site 911045008071 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 911045008072 LysR family transcriptional regulator; Provisional; Region: PRK14997 911045008073 Helix-turn-helix domains; Region: HTH; cl00088 911045008074 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045008075 putative effector binding pocket; other site 911045008076 dimerization interface [polypeptide binding]; other site 911045008077 AAA domain; Region: AAA_33; pfam13671 911045008078 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045008079 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 911045008080 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045008081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045008082 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 911045008083 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 911045008084 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 911045008085 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 911045008086 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045008087 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 911045008088 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045008089 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045008090 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 911045008091 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 911045008092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045008093 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045008094 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045008095 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 911045008096 NMT1-like family; Region: NMT1_2; cl15260 911045008097 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 911045008098 Helix-turn-helix domains; Region: HTH; cl00088 911045008099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045008100 dimerization interface [polypeptide binding]; other site 911045008101 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 911045008102 Subunit I/III interface [polypeptide binding]; other site 911045008103 CoA-transferase family III; Region: CoA_transf_3; pfam02515 911045008104 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 911045008105 CoA-transferase family III; Region: CoA_transf_3; pfam02515 911045008106 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045008107 Helix-turn-helix domains; Region: HTH; cl00088 911045008108 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 911045008109 dimerization interface [polypeptide binding]; other site 911045008110 substrate binding pocket [chemical binding]; other site 911045008111 BCCT family transporter; Region: BCCT; cl00569 911045008112 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 911045008113 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 911045008114 putative active site [active] 911045008115 metal binding site [ion binding]; metal-binding site 911045008116 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045008117 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045008118 DNA binding site [nucleotide binding] 911045008119 domain linker motif; other site 911045008120 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045008121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045008122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008123 dimer interface [polypeptide binding]; other site 911045008124 conserved gate region; other site 911045008125 putative PBP binding loops; other site 911045008126 ABC-ATPase subunit interface; other site 911045008127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008128 dimer interface [polypeptide binding]; other site 911045008129 conserved gate region; other site 911045008130 putative PBP binding loops; other site 911045008131 ABC-ATPase subunit interface; other site 911045008132 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045008133 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045008134 Walker A/P-loop; other site 911045008135 ATP binding site [chemical binding]; other site 911045008136 Q-loop/lid; other site 911045008137 ABC transporter signature motif; other site 911045008138 Walker B; other site 911045008139 D-loop; other site 911045008140 H-loop/switch region; other site 911045008141 TOBE domain; Region: TOBE_2; cl01440 911045008142 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 911045008143 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 911045008144 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045008145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045008146 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 911045008147 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 911045008148 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 911045008149 Cu(I) binding site [ion binding]; other site 911045008150 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 911045008151 Transcriptional regulator [Transcription]; Region: IclR; COG1414 911045008152 Helix-turn-helix domains; Region: HTH; cl00088 911045008153 Bacterial transcriptional regulator; Region: IclR; pfam01614 911045008154 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045008155 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 911045008156 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 911045008157 putative catalytic residue [active] 911045008158 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 911045008159 Chain length determinant protein; Region: Wzz; cl15801 911045008160 Chain length determinant protein; Region: Wzz; cl15801 911045008161 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045008162 P-loop; other site 911045008163 Magnesium ion binding site [ion binding]; other site 911045008164 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 911045008165 Bacterial sugar transferase; Region: Bac_transf; cl00939 911045008166 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045008167 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 911045008168 putative ADP-binding pocket [chemical binding]; other site 911045008169 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 911045008170 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 911045008171 SLBB domain; Region: SLBB; pfam10531 911045008172 MatE; Region: MatE; cl10513 911045008173 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045008174 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 911045008175 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668 911045008176 metal binding site [ion binding]; metal-binding site 911045008177 putative dimer interface [polypeptide binding]; other site 911045008178 Amidinotransferase; Region: Amidinotransf; cl12043 911045008179 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 911045008180 ornithine cyclodeaminase; Validated; Region: PRK07589 911045008181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045008182 Helix-turn-helix domains; Region: HTH; cl00088 911045008183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045008184 Helix-turn-helix domains; Region: HTH; cl00088 911045008185 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045008186 dimerization interface [polypeptide binding]; other site 911045008187 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045008188 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045008189 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045008190 DctM-like transporters; Region: DctM; pfam06808 911045008191 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045008192 Arginase family; Region: Arginase; cl00306 911045008193 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045008194 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 911045008195 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045008196 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 911045008197 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 911045008198 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 911045008199 putative active site [active] 911045008200 putative substrate binding site [chemical binding]; other site 911045008201 putative cosubstrate binding site; other site 911045008202 catalytic site [active] 911045008203 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045008204 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 911045008205 conserved cys residue [active] 911045008206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045008207 BCCT family transporter; Region: BCCT; cl00569 911045008208 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 911045008209 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 911045008210 FAD binding pocket [chemical binding]; other site 911045008211 FAD binding motif [chemical binding]; other site 911045008212 phosphate binding motif [ion binding]; other site 911045008213 beta-alpha-beta structure motif; other site 911045008214 NAD binding pocket [chemical binding]; other site 911045008215 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045008216 catalytic loop [active] 911045008217 iron binding site [ion binding]; other site 911045008218 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 911045008219 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 911045008220 [2Fe-2S] cluster binding site [ion binding]; other site 911045008221 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 911045008222 putative alpha subunit interface [polypeptide binding]; other site 911045008223 putative active site [active] 911045008224 putative substrate binding site [chemical binding]; other site 911045008225 Fe binding site [ion binding]; other site 911045008226 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 911045008227 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 911045008228 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 911045008229 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045008230 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 911045008231 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 911045008232 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045008233 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 911045008234 conserved cys residue [active] 911045008235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045008236 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 911045008237 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 911045008238 putative ligand binding site [chemical binding]; other site 911045008239 HEAT repeats; Region: HEAT_2; pfam13646 911045008240 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045008241 TM-ABC transporter signature motif; other site 911045008242 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045008243 TM-ABC transporter signature motif; other site 911045008244 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 911045008245 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 911045008246 Walker A/P-loop; other site 911045008247 ATP binding site [chemical binding]; other site 911045008248 Q-loop/lid; other site 911045008249 ABC transporter signature motif; other site 911045008250 Walker B; other site 911045008251 D-loop; other site 911045008252 H-loop/switch region; other site 911045008253 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 911045008254 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 911045008255 Walker A/P-loop; other site 911045008256 ATP binding site [chemical binding]; other site 911045008257 Q-loop/lid; other site 911045008258 ABC transporter signature motif; other site 911045008259 Walker B; other site 911045008260 D-loop; other site 911045008261 H-loop/switch region; other site 911045008262 UreD urease accessory protein; Region: UreD; cl00530 911045008263 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 911045008264 alpha-gamma subunit interface [polypeptide binding]; other site 911045008265 beta-gamma subunit interface [polypeptide binding]; other site 911045008266 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cl00533 911045008267 alpha-beta subunit interface [polypeptide binding]; other site 911045008268 urease subunit alpha; Reviewed; Region: ureC; PRK13207 911045008269 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 911045008270 subunit interactions [polypeptide binding]; other site 911045008271 active site 911045008272 flap region; other site 911045008273 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 911045008274 dimer interface [polypeptide binding]; other site 911045008275 catalytic residues [active] 911045008276 UreF; Region: UreF; pfam01730 911045008277 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045008278 FAD dependent oxidoreductase; Region: DAO; pfam01266 911045008279 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 911045008280 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 911045008281 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045008282 Phosphotransferase enzyme family; Region: APH; pfam01636 911045008283 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 911045008284 active site 911045008285 substrate binding site [chemical binding]; other site 911045008286 ATP binding site [chemical binding]; other site 911045008287 dimer interface [polypeptide binding]; other site 911045008288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008289 dimer interface [polypeptide binding]; other site 911045008290 conserved gate region; other site 911045008291 ABC-ATPase subunit interface; other site 911045008292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008293 dimer interface [polypeptide binding]; other site 911045008294 conserved gate region; other site 911045008295 putative PBP binding loops; other site 911045008296 ABC-ATPase subunit interface; other site 911045008297 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 911045008298 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045008299 Walker A/P-loop; other site 911045008300 ATP binding site [chemical binding]; other site 911045008301 Q-loop/lid; other site 911045008302 ABC transporter signature motif; other site 911045008303 Walker B; other site 911045008304 D-loop; other site 911045008305 H-loop/switch region; other site 911045008306 NMT1-like family; Region: NMT1_2; cl15260 911045008307 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 911045008308 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 911045008309 Helix-turn-helix domains; Region: HTH; cl00088 911045008310 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045008311 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 911045008312 Helix-turn-helix domains; Region: HTH; cl00088 911045008313 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 911045008314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045008315 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045008316 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045008317 Cupin domain; Region: Cupin_2; cl09118 911045008318 NMT1-like family; Region: NMT1_2; cl15260 911045008319 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 911045008320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045008321 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 911045008322 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 911045008323 Walker A/P-loop; other site 911045008324 ATP binding site [chemical binding]; other site 911045008325 Q-loop/lid; other site 911045008326 ABC transporter signature motif; other site 911045008327 Walker B; other site 911045008328 D-loop; other site 911045008329 H-loop/switch region; other site 911045008330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008331 dimer interface [polypeptide binding]; other site 911045008332 conserved gate region; other site 911045008333 putative PBP binding loops; other site 911045008334 ABC-ATPase subunit interface; other site 911045008335 acetolactate synthase; Reviewed; Region: PRK08322 911045008336 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045008337 PYR/PP interface [polypeptide binding]; other site 911045008338 dimer interface [polypeptide binding]; other site 911045008339 TPP binding site [chemical binding]; other site 911045008340 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 911045008341 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 911045008342 TPP-binding site [chemical binding]; other site 911045008343 dimer interface [polypeptide binding]; other site 911045008344 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 911045008345 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 911045008346 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 911045008347 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 911045008348 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 911045008349 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 911045008350 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 911045008351 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 911045008352 TSCPD domain; Region: TSCPD; cl14834 911045008353 Response regulator receiver domain; Region: Response_reg; pfam00072 911045008354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045008355 active site 911045008356 phosphorylation site [posttranslational modification] 911045008357 intermolecular recognition site; other site 911045008358 dimerization interface [polypeptide binding]; other site 911045008359 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534 911045008360 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 911045008361 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045008362 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045008363 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 911045008364 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045008365 catalytic residue [active] 911045008366 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 911045008367 putative ABC transporter; Region: ycf24; CHL00085 911045008368 FeS assembly ATPase SufC; Region: sufC; TIGR01978 911045008369 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 911045008370 Walker A/P-loop; other site 911045008371 ATP binding site [chemical binding]; other site 911045008372 Q-loop/lid; other site 911045008373 ABC transporter signature motif; other site 911045008374 Walker B; other site 911045008375 D-loop; other site 911045008376 H-loop/switch region; other site 911045008377 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 911045008378 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 911045008379 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 911045008380 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 911045008381 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045008382 catalytic residue [active] 911045008383 Domain of unknown function DUF59; Region: DUF59; cl00941 911045008384 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 911045008385 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 911045008386 TfoX N-terminal domain; Region: TfoX_N; cl01167 911045008387 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045008388 metal binding site [ion binding]; metal-binding site 911045008389 active site 911045008390 I-site; other site 911045008391 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 911045008392 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 911045008393 ATP binding site [chemical binding]; other site 911045008394 Mg++ binding site [ion binding]; other site 911045008395 motif III; other site 911045008396 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045008397 nucleotide binding region [chemical binding]; other site 911045008398 ATP-binding site [chemical binding]; other site 911045008399 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 911045008400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045008401 ATP binding site [chemical binding]; other site 911045008402 Mg2+ binding site [ion binding]; other site 911045008403 G-X-G motif; other site 911045008404 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 911045008405 anchoring element; other site 911045008406 dimer interface [polypeptide binding]; other site 911045008407 ATP binding site [chemical binding]; other site 911045008408 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 911045008409 active site 911045008410 metal binding site [ion binding]; metal-binding site 911045008411 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 911045008412 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045008413 Sel1 repeat; Region: Sel1; cl02723 911045008414 Phosphate transporter family; Region: PHO4; cl00396 911045008415 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 911045008416 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 911045008417 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045008418 Int/Topo IB signature motif; other site 911045008419 active site 911045008420 DNA binding site [nucleotide binding] 911045008421 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045008422 non-specific DNA binding site [nucleotide binding]; other site 911045008423 salt bridge; other site 911045008424 sequence-specific DNA binding site [nucleotide binding]; other site 911045008425 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 911045008426 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 911045008427 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 911045008428 DNA primase, catalytic core; Region: dnaG; TIGR01391 911045008429 CHC2 zinc finger; Region: zf-CHC2; cl15369 911045008430 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 911045008431 Phage associated DNA primase [General function prediction only]; Region: COG3378 911045008432 D5 N terminal like; Region: D5_N; cl07360 911045008433 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 911045008434 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 911045008435 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 911045008436 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 911045008437 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 911045008438 oligomer interface [polypeptide binding]; other site 911045008439 active site residues [active] 911045008440 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 911045008441 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 911045008442 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 911045008443 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 911045008444 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 911045008445 Baseplate J-like protein; Region: Baseplate_J; cl01294 911045008446 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 911045008447 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 911045008448 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 911045008449 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 911045008450 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 911045008451 Phage tail tube protein FII; Region: Phage_tube; cl01390 911045008452 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 911045008453 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 911045008454 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 911045008455 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 911045008456 Phage Tail Protein X; Region: Phage_tail_X; cl02088 911045008457 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 911045008458 Peptidase M15; Region: Peptidase_M15_3; cl01194 911045008459 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 911045008460 Catalytic site; other site 911045008461 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045008462 AAA domain; Region: AAA_21; pfam13304 911045008463 BRO family, N-terminal domain; Region: Bro-N; cl10591 911045008464 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045008465 putative catalytic site [active] 911045008466 putative metal binding site [ion binding]; other site 911045008467 putative phosphate binding site [ion binding]; other site 911045008468 biotin synthase; Region: bioB; TIGR00433 911045008469 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045008470 FeS/SAM binding site; other site 911045008471 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 911045008472 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 911045008473 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045008474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045008475 catalytic residue [active] 911045008476 AAA domain; Region: AAA_26; pfam13500 911045008477 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045008478 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 911045008479 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045008480 inhibitor-cofactor binding pocket; inhibition site 911045008481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045008482 catalytic residue [active] 911045008483 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 911045008484 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 911045008485 dimer interface [polypeptide binding]; other site 911045008486 active site 911045008487 CoA binding pocket [chemical binding]; other site 911045008488 YceI-like domain; Region: YceI; cl01001 911045008489 Cytochrome c; Region: Cytochrom_C; cl11414 911045008490 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 911045008491 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045008492 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045008493 DNA binding residues [nucleotide binding] 911045008494 Transcriptional regulators [Transcription]; Region: MarR; COG1846 911045008495 Helix-turn-helix domains; Region: HTH; cl00088 911045008496 Helix-turn-helix domains; Region: HTH; cl00088 911045008497 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 911045008498 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045008499 N-terminal plug; other site 911045008500 ligand-binding site [chemical binding]; other site 911045008501 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 911045008502 Ferritin-like domain; Region: Ferritin; pfam00210 911045008503 ferroxidase diiron center [ion binding]; other site 911045008504 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045008505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045008506 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 911045008507 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045008508 N-terminal plug; other site 911045008509 ligand-binding site [chemical binding]; other site 911045008510 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 911045008511 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 911045008512 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045008513 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 911045008514 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 911045008515 putative ligand binding residues [chemical binding]; other site 911045008516 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045008517 ABC-ATPase subunit interface; other site 911045008518 dimer interface [polypeptide binding]; other site 911045008519 putative PBP binding regions; other site 911045008520 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 911045008521 ABC-ATPase subunit interface; other site 911045008522 dimer interface [polypeptide binding]; other site 911045008523 putative PBP binding regions; other site 911045008524 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 911045008525 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 911045008526 Walker A/P-loop; other site 911045008527 ATP binding site [chemical binding]; other site 911045008528 Q-loop/lid; other site 911045008529 ABC transporter signature motif; other site 911045008530 Walker B; other site 911045008531 D-loop; other site 911045008532 H-loop/switch region; other site 911045008533 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 911045008534 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 911045008535 Sodium:solute symporter family; Region: SSF; cl00456 911045008536 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 911045008537 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045008538 ligand binding site [chemical binding]; other site 911045008539 flexible hinge region; other site 911045008540 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 911045008541 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 911045008542 metal binding triad; other site 911045008543 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 911045008544 active site 911045008545 substrate binding site [chemical binding]; other site 911045008546 catalytic site [active] 911045008547 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045008548 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045008549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045008550 Helix-turn-helix domains; Region: HTH; cl00088 911045008551 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045008552 dimerization interface [polypeptide binding]; other site 911045008553 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045008554 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045008555 DctM-like transporters; Region: DctM; pfam06808 911045008556 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045008557 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 911045008558 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 911045008559 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045008560 catalytic residue [active] 911045008561 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 911045008562 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 911045008563 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 911045008564 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 911045008565 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045008566 Helix-turn-helix domains; Region: HTH; cl00088 911045008567 Helix-turn-helix domains; Region: HTH; cl00088 911045008568 Winged helix-turn helix; Region: HTH_29; pfam13551 911045008569 Helix-turn-helix domains; Region: HTH; cl00088 911045008570 Integrase core domain; Region: rve; cl01316 911045008571 Integrase core domain; Region: rve_3; cl15866 911045008572 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 911045008573 FMN-binding domain; Region: FMN_bind; cl01081 911045008574 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 911045008575 4Fe-4S binding domain; Region: Fer4_5; pfam12801 911045008576 nitrous-oxide reductase; Validated; Region: PRK02888 911045008577 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045008578 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 911045008579 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 911045008580 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 911045008581 Walker A/P-loop; other site 911045008582 ATP binding site [chemical binding]; other site 911045008583 Q-loop/lid; other site 911045008584 ABC transporter signature motif; other site 911045008585 Walker B; other site 911045008586 D-loop; other site 911045008587 H-loop/switch region; other site 911045008588 ABC-2 type transporter; Region: ABC2_membrane; cl11417 911045008589 NosL; Region: NosL; cl01769 911045008590 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045008591 non-specific DNA binding site [nucleotide binding]; other site 911045008592 salt bridge; other site 911045008593 sequence-specific DNA binding site [nucleotide binding]; other site 911045008594 arginine decarboxylase; Provisional; Region: PRK05354 911045008595 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 911045008596 dimer interface [polypeptide binding]; other site 911045008597 active site 911045008598 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045008599 catalytic residues [active] 911045008600 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 911045008601 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 911045008602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045008603 NAD(P) binding pocket [chemical binding]; other site 911045008604 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 911045008605 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 911045008606 dimer interface [polypeptide binding]; other site 911045008607 active site 911045008608 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045008609 catalytic residues [active] 911045008610 substrate binding site [chemical binding]; other site 911045008611 Arginase family; Region: Arginase; cl00306 911045008612 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 911045008613 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 911045008614 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045008615 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 911045008616 thymidylate kinase; Validated; Region: tmk; PRK00698 911045008617 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 911045008618 TMP-binding site; other site 911045008619 ATP-binding site [chemical binding]; other site 911045008620 DNA polymerase III subunit delta'; Validated; Region: PRK07471 911045008621 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045008622 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 911045008623 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 911045008624 active site 911045008625 HIGH motif; other site 911045008626 KMSKS motif; other site 911045008627 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 911045008628 tRNA binding surface [nucleotide binding]; other site 911045008629 anticodon binding site; other site 911045008630 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 911045008631 active site 911045008632 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045008633 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 911045008634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045008635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045008636 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 911045008637 active site 911045008638 FMN binding site [chemical binding]; other site 911045008639 substrate binding site [chemical binding]; other site 911045008640 homotetramer interface [polypeptide binding]; other site 911045008641 catalytic residue [active] 911045008642 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 911045008643 classical (c) SDRs; Region: SDR_c; cd05233 911045008644 NAD(P) binding site [chemical binding]; other site 911045008645 active site 911045008646 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045008647 Helix-turn-helix domains; Region: HTH; cl00088 911045008648 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 911045008649 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045008650 substrate binding site [chemical binding]; other site 911045008651 oxyanion hole (OAH) forming residues; other site 911045008652 trimer interface [polypeptide binding]; other site 911045008653 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045008654 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 911045008655 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045008656 active site 911045008657 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 911045008658 AMP-binding enzyme; Region: AMP-binding; cl15778 911045008659 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045008660 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 911045008661 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 911045008662 putative ligand binding site [chemical binding]; other site 911045008663 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045008664 TM-ABC transporter signature motif; other site 911045008665 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045008666 TM-ABC transporter signature motif; other site 911045008667 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 911045008668 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 911045008669 Walker A/P-loop; other site 911045008670 ATP binding site [chemical binding]; other site 911045008671 Q-loop/lid; other site 911045008672 ABC transporter signature motif; other site 911045008673 Walker B; other site 911045008674 D-loop; other site 911045008675 H-loop/switch region; other site 911045008676 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045008677 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 911045008678 Walker A/P-loop; other site 911045008679 ATP binding site [chemical binding]; other site 911045008680 Q-loop/lid; other site 911045008681 ABC transporter signature motif; other site 911045008682 Walker B; other site 911045008683 D-loop; other site 911045008684 H-loop/switch region; other site 911045008685 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045008686 active site 911045008687 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045008688 homotrimer interaction site [polypeptide binding]; other site 911045008689 putative active site [active] 911045008690 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 911045008691 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 911045008692 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 911045008693 CoA-transferase family III; Region: CoA_transf_3; pfam02515 911045008694 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 911045008695 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045008696 active site 911045008697 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 911045008698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045008699 binding surface 911045008700 TPR motif; other site 911045008701 Protein of unknown function, DUF480; Region: DUF480; cl01209 911045008702 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 911045008703 hypothetical protein; Provisional; Region: PRK09936 911045008704 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 911045008705 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 911045008706 active site 911045008707 homodimer interface [polypeptide binding]; other site 911045008708 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 911045008709 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 911045008710 NAD binding site [chemical binding]; other site 911045008711 substrate binding site [chemical binding]; other site 911045008712 catalytic Zn binding site [ion binding]; other site 911045008713 tetramer interface [polypeptide binding]; other site 911045008714 structural Zn binding site [ion binding]; other site 911045008715 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 911045008716 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 911045008717 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 911045008718 phosphate binding site [ion binding]; other site 911045008719 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 911045008720 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045008721 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 911045008722 active site 2 [active] 911045008723 active site 1 [active] 911045008724 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 911045008725 active site 2 [active] 911045008726 active site 1 [active] 911045008727 LysE type translocator; Region: LysE; cl00565 911045008728 LysE type translocator; Region: LysE; cl00565 911045008729 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 911045008730 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 911045008731 metal binding site [ion binding]; metal-binding site 911045008732 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 911045008733 Protein of unknown function (DUF989); Region: DUF989; pfam06181 911045008734 Predicted membrane protein [Function unknown]; Region: COG3748 911045008735 Cytochrome c; Region: Cytochrom_C; cl11414 911045008736 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 911045008737 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 911045008738 putative ligand binding site [chemical binding]; other site 911045008739 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045008740 TM-ABC transporter signature motif; other site 911045008741 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045008742 TM-ABC transporter signature motif; other site 911045008743 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 911045008744 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 911045008745 Walker A/P-loop; other site 911045008746 ATP binding site [chemical binding]; other site 911045008747 Q-loop/lid; other site 911045008748 ABC transporter signature motif; other site 911045008749 Walker B; other site 911045008750 D-loop; other site 911045008751 H-loop/switch region; other site 911045008752 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 911045008753 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 911045008754 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 911045008755 XdhC Rossmann domain; Region: XdhC_C; pfam13478 911045008756 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 911045008757 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 911045008758 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045008759 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 911045008760 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 911045008761 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 911045008762 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 911045008763 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 911045008764 active site 911045008765 homotetramer interface [polypeptide binding]; other site 911045008766 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045008767 Helix-turn-helix domains; Region: HTH; cl00088 911045008768 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045008769 dimerization interface [polypeptide binding]; other site 911045008770 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 911045008771 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 911045008772 NADP binding site [chemical binding]; other site 911045008773 dimer interface [polypeptide binding]; other site 911045008774 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 911045008775 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 911045008776 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 911045008777 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 911045008778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045008779 Membrane transport protein; Region: Mem_trans; cl09117 911045008780 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 911045008781 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 911045008782 putative acyl-acceptor binding pocket; other site 911045008783 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 911045008784 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 911045008785 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 911045008786 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 911045008787 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 911045008788 AMP-binding enzyme; Region: AMP-binding; cl15778 911045008789 acyl-CoA synthetase; Validated; Region: PRK07867 911045008790 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 911045008791 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 911045008792 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 911045008793 catalytic residues [active] 911045008794 enolase; Provisional; Region: eno; PRK00077 911045008795 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 911045008796 dimer interface [polypeptide binding]; other site 911045008797 metal binding site [ion binding]; metal-binding site 911045008798 substrate binding pocket [chemical binding]; other site 911045008799 NeuB family; Region: NeuB; cl00496 911045008800 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 911045008801 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 911045008802 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 911045008803 CysD dimerization site [polypeptide binding]; other site 911045008804 G1 box; other site 911045008805 putative GEF interaction site [polypeptide binding]; other site 911045008806 GTP/Mg2+ binding site [chemical binding]; other site 911045008807 Switch I region; other site 911045008808 G2 box; other site 911045008809 G3 box; other site 911045008810 Switch II region; other site 911045008811 G4 box; other site 911045008812 G5 box; other site 911045008813 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 911045008814 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 911045008815 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 911045008816 ligand-binding site [chemical binding]; other site 911045008817 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 911045008818 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 911045008819 Active Sites [active] 911045008820 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 911045008821 active site 911045008822 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 911045008823 active site 911045008824 tetramer interface; other site 911045008825 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045008826 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 911045008827 putative NAD(P) binding site [chemical binding]; other site 911045008828 active site 911045008829 putative substrate binding site [chemical binding]; other site 911045008830 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 911045008831 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 911045008832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045008833 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 911045008834 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 911045008835 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 911045008836 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 911045008837 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 911045008838 active site 911045008839 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 911045008840 active site 911045008841 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 911045008842 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 911045008843 active site 911045008844 (T/H)XGH motif; other site 911045008845 DNA gyrase subunit A; Validated; Region: PRK05560 911045008846 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 911045008847 CAP-like domain; other site 911045008848 active site 911045008849 primary dimer interface [polypeptide binding]; other site 911045008850 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 911045008851 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 911045008852 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 911045008853 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 911045008854 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 911045008855 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 911045008856 MarC family integral membrane protein; Region: MarC; cl00919 911045008857 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 911045008858 Cation efflux family; Region: Cation_efflux; cl00316 911045008859 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 911045008860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045008861 NAD(P) binding site [chemical binding]; other site 911045008862 active site 911045008863 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 911045008864 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 911045008865 DNA-binding site [nucleotide binding]; DNA binding site 911045008866 RNA-binding motif; other site 911045008867 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 911045008868 DNA-binding site [nucleotide binding]; DNA binding site 911045008869 RNA-binding motif; other site 911045008870 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045008871 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 911045008872 dimer interface [polypeptide binding]; other site 911045008873 active site 911045008874 metal binding site [ion binding]; metal-binding site 911045008875 glutathione binding site [chemical binding]; other site 911045008876 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 911045008877 dimer interface [polypeptide binding]; other site 911045008878 ssDNA binding site [nucleotide binding]; other site 911045008879 tetramer (dimer of dimers) interface [polypeptide binding]; other site 911045008880 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 911045008881 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 911045008882 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 911045008883 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 911045008884 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 911045008885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045008886 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 911045008887 substrate binding pocket [chemical binding]; other site 911045008888 substrate-Mg2+ binding site; other site 911045008889 aspartate-rich region 1; other site 911045008890 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 911045008891 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 911045008892 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 911045008893 Protein export membrane protein; Region: SecD_SecF; cl14618 911045008894 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 911045008895 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 911045008896 Protein export membrane protein; Region: SecD_SecF; cl14618 911045008897 Preprotein translocase subunit; Region: YajC; cl00806 911045008898 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 911045008899 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045008900 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 911045008901 putative peptidoglycan binding site; other site 911045008902 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 911045008903 Peptidase family M23; Region: Peptidase_M23; pfam01551 911045008904 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 911045008905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045008906 S-adenosylmethionine binding site [chemical binding]; other site 911045008907 Survival protein SurE; Region: SurE; cl00448 911045008908 seryl-tRNA synthetase; Provisional; Region: PRK05431 911045008909 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 911045008910 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 911045008911 dimer interface [polypeptide binding]; other site 911045008912 active site 911045008913 motif 1; other site 911045008914 motif 2; other site 911045008915 motif 3; other site 911045008916 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 911045008917 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 911045008918 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 911045008919 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045008920 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 911045008921 Walker A/P-loop; other site 911045008922 ATP binding site [chemical binding]; other site 911045008923 Q-loop/lid; other site 911045008924 ABC transporter signature motif; other site 911045008925 Walker B; other site 911045008926 D-loop; other site 911045008927 H-loop/switch region; other site 911045008928 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 911045008929 ScpA/B protein; Region: ScpA_ScpB; cl00598 911045008930 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 911045008931 beta-adaptin; Provisional; Region: PTZ00429 911045008932 Sporulation related domain; Region: SPOR; cl10051 911045008933 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 911045008934 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 911045008935 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 911045008936 active site 911045008937 HIGH motif; other site 911045008938 KMSK motif region; other site 911045008939 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 911045008940 tRNA binding surface [nucleotide binding]; other site 911045008941 anticodon binding site; other site 911045008942 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 911045008943 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 911045008944 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 911045008945 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 911045008946 putative phosphate binding site [ion binding]; other site 911045008947 putative catalytic site [active] 911045008948 active site 911045008949 metal binding site A [ion binding]; metal-binding site 911045008950 DNA binding site [nucleotide binding] 911045008951 putative AP binding site [nucleotide binding]; other site 911045008952 putative metal binding site B [ion binding]; other site 911045008953 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 911045008954 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045008955 active site 911045008956 catalytic tetrad [active] 911045008957 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 911045008958 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 911045008959 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 911045008960 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045008961 catalytic residue [active] 911045008962 Pyruvate formate lyase 1; Region: PFL1; cd01678 911045008963 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 911045008964 coenzyme A binding site [chemical binding]; other site 911045008965 active site 911045008966 catalytic residues [active] 911045008967 glycine loop; other site 911045008968 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 911045008969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045008970 FeS/SAM binding site; other site 911045008971 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 911045008972 hypothetical protein; Provisional; Region: PRK07483 911045008973 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045008974 inhibitor-cofactor binding pocket; inhibition site 911045008975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045008976 catalytic residue [active] 911045008977 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045008978 MatE; Region: MatE; cl10513 911045008979 MatE; Region: MatE; cl10513 911045008980 TetR family transcriptional regulator; Provisional; Region: PRK14996 911045008981 Helix-turn-helix domains; Region: HTH; cl00088 911045008982 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 911045008983 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 911045008984 active site 911045008985 trimer interface [polypeptide binding]; other site 911045008986 dimer interface [polypeptide binding]; other site 911045008987 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 911045008988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045008989 S-adenosylmethionine binding site [chemical binding]; other site 911045008990 RF-1 domain; Region: RF-1; cl02875 911045008991 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 911045008992 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045008993 inhibitor-cofactor binding pocket; inhibition site 911045008994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045008995 catalytic residue [active] 911045008996 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 911045008997 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 911045008998 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 911045008999 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 911045009000 putative active site [active] 911045009001 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 911045009002 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 911045009003 HflX GTPase family; Region: HflX; cd01878 911045009004 G1 box; other site 911045009005 GTP/Mg2+ binding site [chemical binding]; other site 911045009006 Switch I region; other site 911045009007 G2 box; other site 911045009008 G3 box; other site 911045009009 Switch II region; other site 911045009010 G4 box; other site 911045009011 G5 box; other site 911045009012 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 911045009013 Sm1 motif; other site 911045009014 intra - hexamer interaction site; other site 911045009015 inter - hexamer interaction site [polypeptide binding]; other site 911045009016 nucleotide binding pocket [chemical binding]; other site 911045009017 Sm2 motif; other site 911045009018 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 911045009019 homodimer interface [polypeptide binding]; other site 911045009020 substrate-cofactor binding pocket; other site 911045009021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045009022 catalytic residue [active] 911045009023 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 911045009024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045009025 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 911045009026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045009027 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 911045009028 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 911045009029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045009030 active site 911045009031 phosphorylation site [posttranslational modification] 911045009032 intermolecular recognition site; other site 911045009033 dimerization interface [polypeptide binding]; other site 911045009034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045009035 Walker A motif; other site 911045009036 ATP binding site [chemical binding]; other site 911045009037 Walker B motif; other site 911045009038 arginine finger; other site 911045009039 Helix-turn-helix domains; Region: HTH; cl00088 911045009040 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 911045009041 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045009042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045009043 dimer interface [polypeptide binding]; other site 911045009044 phosphorylation site [posttranslational modification] 911045009045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045009046 ATP binding site [chemical binding]; other site 911045009047 Mg2+ binding site [ion binding]; other site 911045009048 G-X-G motif; other site 911045009049 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 911045009050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045009051 active site 911045009052 phosphorylation site [posttranslational modification] 911045009053 intermolecular recognition site; other site 911045009054 dimerization interface [polypeptide binding]; other site 911045009055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045009056 Walker A motif; other site 911045009057 ATP binding site [chemical binding]; other site 911045009058 Walker B motif; other site 911045009059 arginine finger; other site 911045009060 Helix-turn-helix domains; Region: HTH; cl00088 911045009061 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 911045009062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045009063 dimer interface [polypeptide binding]; other site 911045009064 phosphorylation site [posttranslational modification] 911045009065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045009066 ATP binding site [chemical binding]; other site 911045009067 Mg2+ binding site [ion binding]; other site 911045009068 G-X-G motif; other site 911045009069 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 911045009070 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 911045009071 FMN binding site [chemical binding]; other site 911045009072 active site 911045009073 catalytic residues [active] 911045009074 substrate binding site [chemical binding]; other site 911045009075 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 911045009076 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 911045009077 substrate binding site; other site 911045009078 dimer interface; other site 911045009079 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 911045009080 homotrimer interaction site [polypeptide binding]; other site 911045009081 zinc binding site [ion binding]; other site 911045009082 CDP-binding sites; other site 911045009083 Competence-damaged protein; Region: CinA; cl00666 911045009084 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 911045009085 nudix motif; other site 911045009086 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 911045009087 putative coenzyme Q binding site [chemical binding]; other site 911045009088 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045009089 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045009090 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045009091 Helix-turn-helix domains; Region: HTH; cl00088 911045009092 enoyl-CoA hydratase; Provisional; Region: PRK05980 911045009093 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045009094 substrate binding site [chemical binding]; other site 911045009095 oxyanion hole (OAH) forming residues; other site 911045009096 trimer interface [polypeptide binding]; other site 911045009097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045009098 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045009099 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045009100 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 911045009101 EamA-like transporter family; Region: EamA; cl01037 911045009102 lipoyl synthase; Provisional; Region: PRK05481 911045009103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045009104 FeS/SAM binding site; other site 911045009105 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 911045009106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045009107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 911045009108 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 911045009109 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 911045009110 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 911045009111 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 911045009112 E3 interaction surface; other site 911045009113 lipoyl attachment site [posttranslational modification]; other site 911045009114 e3 binding domain; Region: E3_binding; pfam02817 911045009115 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 911045009116 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 911045009117 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 911045009118 E3 interaction surface; other site 911045009119 lipoyl attachment site [posttranslational modification]; other site 911045009120 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 911045009121 alpha subunit interface [polypeptide binding]; other site 911045009122 TPP binding site [chemical binding]; other site 911045009123 heterodimer interface [polypeptide binding]; other site 911045009124 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 911045009125 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 911045009126 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 911045009127 tetramer interface [polypeptide binding]; other site 911045009128 TPP-binding site [chemical binding]; other site 911045009129 heterodimer interface [polypeptide binding]; other site 911045009130 phosphorylation loop region [posttranslational modification] 911045009131 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 911045009132 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 911045009133 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045009134 ATP binding site [chemical binding]; other site 911045009135 putative Mg++ binding site [ion binding]; other site 911045009136 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045009137 nucleotide binding region [chemical binding]; other site 911045009138 ATP-binding site [chemical binding]; other site 911045009139 TRCF domain; Region: TRCF; cl04088 911045009140 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 911045009141 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 911045009142 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 911045009143 generic binding surface II; other site 911045009144 ssDNA binding site; other site 911045009145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045009146 ATP binding site [chemical binding]; other site 911045009147 putative Mg++ binding site [ion binding]; other site 911045009148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045009149 nucleotide binding region [chemical binding]; other site 911045009150 ATP-binding site [chemical binding]; other site 911045009151 Protein of unknown function (DUF502); Region: DUF502; cl01107 911045009152 Protein of unknown function (DUF454); Region: DUF454; cl01063 911045009153 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045009154 Helix-turn-helix domains; Region: HTH; cl00088 911045009155 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045009156 putative effector binding pocket; other site 911045009157 dimerization interface [polypeptide binding]; other site 911045009158 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045009159 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045009160 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045009161 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 911045009162 dimer interface [polypeptide binding]; other site 911045009163 substrate binding pocket (H-site) [chemical binding]; other site 911045009164 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 911045009165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045009166 putative substrate translocation pore; other site 911045009167 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 911045009168 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 911045009169 putative lipoprotein; Provisional; Region: PRK09707 911045009170 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 911045009171 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 911045009172 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 911045009173 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 911045009174 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045009175 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 911045009176 putative peroxiredoxin; Provisional; Region: PRK13190 911045009177 decamer (pentamer of dimers) interface [polypeptide binding]; other site 911045009178 catalytic triad [active] 911045009179 dimer interface [polypeptide binding]; other site 911045009180 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 911045009181 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 911045009182 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 911045009183 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 911045009184 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 911045009185 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045009186 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 911045009187 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 911045009188 active site 911045009189 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045009190 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 911045009191 FtsX-like permease family; Region: FtsX; cl15850 911045009192 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 911045009193 FtsX-like permease family; Region: FtsX; cl15850 911045009194 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 911045009195 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 911045009196 Walker A/P-loop; other site 911045009197 ATP binding site [chemical binding]; other site 911045009198 Q-loop/lid; other site 911045009199 ABC transporter signature motif; other site 911045009200 Walker B; other site 911045009201 D-loop; other site 911045009202 H-loop/switch region; other site 911045009203 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 911045009204 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045009205 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045009206 peptide synthase; Provisional; Region: PRK12467 911045009207 AMP-binding enzyme; Region: AMP-binding; cl15778 911045009208 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045009209 Condensation domain; Region: Condensation; pfam00668 911045009210 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045009211 MatE; Region: MatE; cl10513 911045009212 MatE; Region: MatE; cl10513 911045009213 amidase; Provisional; Region: PRK06170 911045009214 Amidase; Region: Amidase; cl11426 911045009215 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 911045009216 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 911045009217 active site 911045009218 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045009219 Condensation domain; Region: Condensation; pfam00668 911045009220 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 911045009221 Nonribosomal peptide synthase; Region: NRPS; pfam08415 911045009222 AMP-binding enzyme; Region: AMP-binding; cl15778 911045009223 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 911045009224 putative FMN binding site [chemical binding]; other site 911045009225 NADPH bind site [chemical binding]; other site 911045009226 peptide synthase; Provisional; Region: PRK12316 911045009227 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045009228 peptide synthase; Provisional; Region: PRK12316 911045009229 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 911045009230 AMP-binding enzyme; Region: AMP-binding; cl15778 911045009231 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045009232 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 911045009233 Nonribosomal peptide synthase; Region: NRPS; pfam08415 911045009234 AMP-binding enzyme; Region: AMP-binding; cl15778 911045009235 AMP-binding enzyme; Region: AMP-binding; cl15778 911045009236 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045009237 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 911045009238 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 911045009239 active site 911045009240 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 911045009241 Acyl transferase domain; Region: Acyl_transf_1; cl08282 911045009242 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045009243 Acyl transferase domain; Region: Acyl_transf_1; cl08282 911045009244 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 911045009245 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 911045009246 AMP-binding enzyme; Region: AMP-binding; cl15778 911045009247 Condensation domain; Region: Condensation; pfam00668 911045009248 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 911045009249 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 911045009250 AMP-binding enzyme; Region: AMP-binding; cl15778 911045009251 AMP-binding enzyme; Region: AMP-binding; cl15778 911045009252 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045009253 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045009254 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045009255 active site 911045009256 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045009257 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 911045009258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045009259 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045009260 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 911045009261 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 911045009262 active site 911045009263 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045009264 peptide synthase; Provisional; Region: PRK12316 911045009265 AMP-binding enzyme; Region: AMP-binding; cl15778 911045009266 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045009267 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 911045009268 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 911045009269 active site 911045009270 Acyl transferase domain; Region: Acyl_transf_1; cl08282 911045009271 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 911045009272 NADP binding site [chemical binding]; other site 911045009273 active site 911045009274 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 911045009275 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 911045009276 Enoylreductase; Region: PKS_ER; smart00829 911045009277 NAD(P) binding site [chemical binding]; other site 911045009278 peptide synthase; Provisional; Region: PRK12316 911045009279 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045009280 Helix-turn-helix domains; Region: HTH; cl00088 911045009281 Helix-turn-helix domains; Region: HTH; cl00088 911045009282 Integrase core domain; Region: rve; cl01316 911045009283 Integrase core domain; Region: rve_3; cl15866 911045009284 TniQ; Region: TniQ; pfam06527 911045009285 Integrase core domain; Region: rve; cl01316 911045009286 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 911045009287 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 911045009288 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 911045009289 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 911045009290 glutaminase active site [active] 911045009291 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 911045009292 dimer interface [polypeptide binding]; other site 911045009293 active site 911045009294 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 911045009295 dimer interface [polypeptide binding]; other site 911045009296 active site 911045009297 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 911045009298 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 911045009299 Substrate binding site; other site 911045009300 Mg++ binding site; other site 911045009301 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 911045009302 active site 911045009303 substrate binding site [chemical binding]; other site 911045009304 CoA binding site [chemical binding]; other site 911045009305 EamA-like transporter family; Region: EamA; cl01037 911045009306 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045009307 EamA-like transporter family; Region: EamA; cl01037 911045009308 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 911045009309 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 911045009310 Ligand Binding Site [chemical binding]; other site 911045009311 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045009312 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045009313 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 911045009314 NMT1-like family; Region: NMT1_2; cl15260 911045009315 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 911045009316 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 911045009317 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 911045009318 Ferritin-like; Region: Ferritin-like; pfam12902 911045009319 Protein of unknown function (DUF692); Region: DUF692; cl01263 911045009320 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 911045009321 Helix-turn-helix domains; Region: HTH; cl00088 911045009322 Helix-turn-helix domains; Region: HTH; cl00088 911045009323 Winged helix-turn helix; Region: HTH_29; pfam13551 911045009324 Helix-turn-helix domains; Region: HTH; cl00088 911045009325 Integrase core domain; Region: rve; cl01316 911045009326 Integrase core domain; Region: rve_3; cl15866 911045009327 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045009328 hypothetical protein; Provisional; Region: PRK07208 911045009329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045009330 UDP-galactopyranose mutase; Region: GLF; pfam03275 911045009331 Iron permease FTR1 family; Region: FTR1; cl00475 911045009332 Uncharacterized conserved protein [Function unknown]; Region: COG3391 911045009333 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 911045009334 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045009335 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 911045009336 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 911045009337 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 911045009338 dimer interface [polypeptide binding]; other site 911045009339 active site 911045009340 metal binding site [ion binding]; metal-binding site 911045009341 ornithine cyclodeaminase; Validated; Region: PRK06141 911045009342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045009343 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 911045009344 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045009345 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045009346 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045009347 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421 911045009348 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 911045009349 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045009350 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 911045009351 Walker A/P-loop; other site 911045009352 ATP binding site [chemical binding]; other site 911045009353 Q-loop/lid; other site 911045009354 ABC transporter signature motif; other site 911045009355 Walker B; other site 911045009356 D-loop; other site 911045009357 H-loop/switch region; other site 911045009358 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 911045009359 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045009360 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 911045009361 CTP synthetase; Validated; Region: pyrG; PRK05380 911045009362 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 911045009363 Catalytic site [active] 911045009364 active site 911045009365 UTP binding site [chemical binding]; other site 911045009366 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 911045009367 active site 911045009368 putative oxyanion hole; other site 911045009369 catalytic triad [active] 911045009370 Preprotein translocase SecG subunit; Region: SecG; cl09123 911045009371 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 911045009372 substrate binding site [chemical binding]; other site 911045009373 dimer interface [polypeptide binding]; other site 911045009374 catalytic triad [active] 911045009375 periplasmic folding chaperone; Provisional; Region: PRK10788 911045009376 SurA N-terminal domain; Region: SurA_N_3; cl07813 911045009377 PPIC-type PPIASE domain; Region: Rotamase; cl08278 911045009378 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 911045009379 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 911045009380 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 911045009381 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 911045009382 active site 911045009383 ribulose/triose binding site [chemical binding]; other site 911045009384 phosphate binding site [ion binding]; other site 911045009385 substrate (anthranilate) binding pocket [chemical binding]; other site 911045009386 product (indole) binding pocket [chemical binding]; other site 911045009387 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 911045009388 trimer interface [polypeptide binding]; other site 911045009389 dimer interface [polypeptide binding]; other site 911045009390 putative active site [active] 911045009391 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 911045009392 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 911045009393 dimer interface [polypeptide binding]; other site 911045009394 putative functional site; other site 911045009395 putative MPT binding site; other site 911045009396 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 911045009397 Competence protein; Region: Competence; cl00471 911045009398 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 911045009399 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 911045009400 active site 911045009401 HIGH motif; other site 911045009402 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 911045009403 active site 911045009404 KMSKS motif; other site 911045009405 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 911045009406 dimer interface [polypeptide binding]; other site 911045009407 Citrate synthase; Region: Citrate_synt; pfam00285 911045009408 active site 911045009409 citrylCoA binding site [chemical binding]; other site 911045009410 NADH binding [chemical binding]; other site 911045009411 cationic pore residues; other site 911045009412 oxalacetate/citrate binding site [chemical binding]; other site 911045009413 coenzyme A binding site [chemical binding]; other site 911045009414 catalytic triad [active] 911045009415 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045009416 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 911045009417 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 911045009418 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 911045009419 acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Region: lipid_A_lpxA; TIGR01852 911045009420 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 911045009421 active site 911045009422 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 911045009423 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 911045009424 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 911045009425 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 911045009426 trimer interface [polypeptide binding]; other site 911045009427 active site 911045009428 UDP-GlcNAc binding site [chemical binding]; other site 911045009429 lipid binding site [chemical binding]; lipid-binding site 911045009430 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 911045009431 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 911045009432 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 911045009433 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 911045009434 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 911045009435 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 911045009436 Surface antigen; Region: Bac_surface_Ag; cl03097 911045009437 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 911045009438 RIP metalloprotease RseP; Region: TIGR00054 911045009439 active site 911045009440 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 911045009441 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 911045009442 putative substrate binding region [chemical binding]; other site 911045009443 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 911045009444 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 911045009445 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 911045009446 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 911045009447 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 911045009448 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 911045009449 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 911045009450 catalytic residue [active] 911045009451 putative FPP diphosphate binding site; other site 911045009452 putative FPP binding hydrophobic cleft; other site 911045009453 dimer interface [polypeptide binding]; other site 911045009454 putative IPP diphosphate binding site; other site 911045009455 ribosome recycling factor; Reviewed; Region: frr; PRK00083 911045009456 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 911045009457 hinge region; other site 911045009458 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 911045009459 putative nucleotide binding site [chemical binding]; other site 911045009460 uridine monophosphate binding site [chemical binding]; other site 911045009461 homohexameric interface [polypeptide binding]; other site 911045009462 elongation factor Ts; Provisional; Region: tsf; PRK09377 911045009463 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 911045009464 Elongation factor TS; Region: EF_TS; pfam00889 911045009465 Elongation factor TS; Region: EF_TS; pfam00889 911045009466 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 911045009467 rRNA interaction site [nucleotide binding]; other site 911045009468 S8 interaction site; other site 911045009469 putative laminin-1 binding site; other site 911045009470 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 911045009471 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 911045009472 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 911045009473 generic binding surface II; other site 911045009474 generic binding surface I; other site 911045009475 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 911045009476 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 911045009477 Walker A/P-loop; other site 911045009478 ATP binding site [chemical binding]; other site 911045009479 Q-loop/lid; other site 911045009480 ABC transporter signature motif; other site 911045009481 Walker B; other site 911045009482 D-loop; other site 911045009483 H-loop/switch region; other site 911045009484 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 911045009485 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 911045009486 FtsX-like permease family; Region: FtsX; cl15850 911045009487 prolyl-tRNA synthetase; Provisional; Region: PRK12325 911045009488 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 911045009489 dimer interface [polypeptide binding]; other site 911045009490 motif 1; other site 911045009491 active site 911045009492 motif 2; other site 911045009493 motif 3; other site 911045009494 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 911045009495 anticodon binding site; other site 911045009496 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 911045009497 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 911045009498 dimer interface [polypeptide binding]; other site 911045009499 substrate binding site [chemical binding]; other site 911045009500 metal binding site [ion binding]; metal-binding site 911045009501 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 911045009502 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045009503 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 911045009504 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 911045009505 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 911045009506 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 911045009507 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 911045009508 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 911045009509 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 911045009510 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 911045009511 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 911045009512 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 911045009513 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 911045009514 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 911045009515 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 911045009516 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 911045009517 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 911045009518 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 911045009519 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 911045009520 4Fe-4S binding domain; Region: Fer4; cl02805 911045009521 4Fe-4S binding domain; Region: Fer4; cl02805 911045009522 NADH dehydrogenase; Region: NADHdh; cl00469 911045009523 NADH dehydrogenase subunit G; Validated; Region: PRK09130 911045009524 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045009525 catalytic loop [active] 911045009526 iron binding site [ion binding]; other site 911045009527 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 911045009528 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 911045009529 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 911045009530 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 911045009531 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 911045009532 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 911045009533 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 911045009534 SLBB domain; Region: SLBB; pfam10531 911045009535 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 911045009536 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 911045009537 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 911045009538 putative dimer interface [polypeptide binding]; other site 911045009539 [2Fe-2S] cluster binding site [ion binding]; other site 911045009540 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 911045009541 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 911045009542 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 911045009543 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 911045009544 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 911045009545 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 911045009546 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 911045009547 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 911045009548 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 911045009549 IHF dimer interface [polypeptide binding]; other site 911045009550 IHF - DNA interface [nucleotide binding]; other site 911045009551 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 911045009552 Found in ATP-dependent protease La (LON); Region: LON; smart00464 911045009553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045009554 Walker A motif; other site 911045009555 ATP binding site [chemical binding]; other site 911045009556 Walker B motif; other site 911045009557 arginine finger; other site 911045009558 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 911045009559 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 911045009560 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 911045009561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045009562 Walker A motif; other site 911045009563 ATP binding site [chemical binding]; other site 911045009564 Walker B motif; other site 911045009565 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 911045009566 Clp protease; Region: CLP_protease; pfam00574 911045009567 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 911045009568 oligomer interface [polypeptide binding]; other site 911045009569 active site residues [active] 911045009570 trigger factor; Provisional; Region: tig; PRK01490 911045009571 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 911045009572 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 911045009573 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 911045009574 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 911045009575 putative substrate binding site [chemical binding]; other site 911045009576 putative ATP binding site [chemical binding]; other site 911045009577 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045009578 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045009579 active site 911045009580 ATP binding site [chemical binding]; other site 911045009581 substrate binding site [chemical binding]; other site 911045009582 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045009583 substrate binding site [chemical binding]; other site 911045009584 activation loop (A-loop); other site 911045009585 activation loop (A-loop); other site 911045009586 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045009587 active site 911045009588 ATP binding site [chemical binding]; other site 911045009589 substrate binding site [chemical binding]; other site 911045009590 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045009591 substrate binding site [chemical binding]; other site 911045009592 activation loop (A-loop); other site 911045009593 activation loop (A-loop); other site 911045009594 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045009595 active site 911045009596 ATP binding site [chemical binding]; other site 911045009597 substrate binding site [chemical binding]; other site 911045009598 activation loop (A-loop); other site 911045009599 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045009600 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 911045009601 dimer interface [polypeptide binding]; other site 911045009602 metal binding site [ion binding]; metal-binding site 911045009603 Nitrogen regulatory protein P-II; Region: P-II; cl00412 911045009604 Nitrogen regulatory protein P-II; Region: P-II; smart00938 911045009605 glutamine synthetase; Provisional; Region: glnA; PRK09469 911045009606 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 911045009607 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 911045009608 YceI-like domain; Region: YceI; cl01001 911045009609 Helix-turn-helix domains; Region: HTH; cl00088 911045009610 Helix-turn-helix domains; Region: HTH; cl00088 911045009611 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 911045009612 dimer interface [polypeptide binding]; other site 911045009613 ligand binding site [chemical binding]; other site 911045009614 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 911045009615 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 911045009616 active site 911045009617 HIGH motif; other site 911045009618 dimer interface [polypeptide binding]; other site 911045009619 KMSKS motif; other site 911045009620 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045009621 RNA binding surface [nucleotide binding]; other site 911045009622 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 911045009623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045009624 S-adenosylmethionine binding site [chemical binding]; other site 911045009625 Protein of unknown function; Region: DUF3971; pfam13116 911045009626 AsmA-like C-terminal region; Region: AsmA_2; cl15864 911045009627 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 911045009628 catalytic triad [active] 911045009629 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 911045009630 dinuclear metal binding motif [ion binding]; other site 911045009631 Peptidase family M23; Region: Peptidase_M23; pfam01551 911045009632 peptide chain release factor 2; Provisional; Region: PRK07342 911045009633 RF-1 domain; Region: RF-1; cl02875 911045009634 RF-1 domain; Region: RF-1; cl02875 911045009635 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 911045009636 Transglycosylase; Region: Transgly; cl07896 911045009637 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045009638 AMIN domain; Region: AMIN; pfam11741 911045009639 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 911045009640 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 911045009641 active site 911045009642 metal binding site [ion binding]; metal-binding site 911045009643 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 911045009644 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 911045009645 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 911045009646 aspartate aminotransferase; Provisional; Region: PRK05764 911045009647 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045009648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045009649 homodimer interface [polypeptide binding]; other site 911045009650 catalytic residue [active] 911045009651 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 911045009652 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 911045009653 catalytic residues [active] 911045009654 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 911045009655 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 911045009656 carboxyltransferase (CT) interaction site; other site 911045009657 biotinylation site [posttranslational modification]; other site 911045009658 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 911045009659 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045009660 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045009661 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 911045009662 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045009663 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 911045009664 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 911045009665 Mechanosensitive ion channel; Region: MS_channel; pfam00924 911045009666 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 911045009667 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 911045009668 HIGH motif; other site 911045009669 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 911045009670 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 911045009671 active site 911045009672 KMSKS motif; other site 911045009673 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 911045009674 tRNA binding surface [nucleotide binding]; other site 911045009675 anticodon binding site; other site 911045009676 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 911045009677 Protein of unknown function (DUF2497); Region: DUF2497; cl11534 911045009678 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 911045009679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045009680 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 911045009681 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 911045009682 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 911045009683 Fatty acid desaturase; Region: FA_desaturase; pfam00487 911045009684 Di-iron ligands [ion binding]; other site 911045009685 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 911045009686 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045009687 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045009688 catalytic residue [active] 911045009689 CobD/Cbib protein; Region: CobD_Cbib; cl00561 911045009690 cobyric acid synthase; Provisional; Region: PRK00784 911045009691 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045009692 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 911045009693 catalytic triad [active] 911045009694 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045009695 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 911045009696 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 911045009697 homodimer interface [polypeptide binding]; other site 911045009698 Walker A motif; other site 911045009699 ATP binding site [chemical binding]; other site 911045009700 hydroxycobalamin binding site [chemical binding]; other site 911045009701 Walker B motif; other site 911045009702 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 911045009703 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 911045009704 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 911045009705 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 911045009706 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045009707 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 911045009708 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 911045009709 Walker B motif; other site 911045009710 homotrimer interface [polypeptide binding]; other site 911045009711 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 911045009712 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 911045009713 dimer interface [polypeptide binding]; other site 911045009714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045009715 catalytic residue [active] 911045009716 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 911045009717 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 911045009718 putative active site [active] 911045009719 catalytic site [active] 911045009720 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 911045009721 putative active site [active] 911045009722 catalytic site [active] 911045009723 LysE type translocator; Region: LysE; cl00565 911045009724 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 911045009725 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 911045009726 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 911045009727 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 911045009728 active site residue [active] 911045009729 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 911045009730 active site residue [active] 911045009731 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045009732 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045009733 Helix-turn-helix domains; Region: HTH; cl00088 911045009734 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 911045009735 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045009736 Helix-turn-helix domains; Region: HTH; cl00088 911045009737 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 911045009738 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 911045009739 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 911045009740 Walker A/P-loop; other site 911045009741 ATP binding site [chemical binding]; other site 911045009742 Q-loop/lid; other site 911045009743 ABC transporter signature motif; other site 911045009744 Walker B; other site 911045009745 D-loop; other site 911045009746 H-loop/switch region; other site 911045009747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045009748 dimer interface [polypeptide binding]; other site 911045009749 conserved gate region; other site 911045009750 putative PBP binding loops; other site 911045009751 ABC-ATPase subunit interface; other site 911045009752 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 911045009753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045009754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045009755 dimer interface [polypeptide binding]; other site 911045009756 conserved gate region; other site 911045009757 putative PBP binding loops; other site 911045009758 ABC-ATPase subunit interface; other site 911045009759 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 911045009760 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045009761 substrate binding pocket [chemical binding]; other site 911045009762 membrane-bound complex binding site; other site 911045009763 hinge residues; other site 911045009764 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 911045009765 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 911045009766 Ligand binding site; other site 911045009767 Putative Catalytic site; other site 911045009768 DXD motif; other site 911045009769 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 911045009770 active site 911045009771 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 911045009772 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 911045009773 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 911045009774 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 911045009775 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 911045009776 active site 911045009777 Zn binding site [ion binding]; other site 911045009778 Protein of unknown function (DUF423); Region: DUF423; cl01008 911045009779 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 911045009780 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 911045009781 active site 911045009782 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045009783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045009784 Coenzyme A binding pocket [chemical binding]; other site 911045009785 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045009786 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045009787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045009788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045009789 Coenzyme A binding pocket [chemical binding]; other site 911045009790 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 911045009791 DHH family; Region: DHH; pfam01368 911045009792 DHHA1 domain; Region: DHHA1; pfam02272 911045009793 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 911045009794 putative active site [active] 911045009795 homoserine dehydrogenase; Provisional; Region: PRK06349 911045009796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045009797 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 911045009798 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 911045009799 aminotransferase; Validated; Region: PRK09148 911045009800 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045009801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045009802 homodimer interface [polypeptide binding]; other site 911045009803 catalytic residue [active] 911045009804 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 911045009805 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 911045009806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045009807 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 911045009808 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 911045009809 23S rRNA interface [nucleotide binding]; other site 911045009810 L3 interface [polypeptide binding]; other site 911045009811 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 911045009812 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 911045009813 Leucine-rich repeats; other site 911045009814 Leucine rich repeat; Region: LRR_8; pfam13855 911045009815 Substrate binding site [chemical binding]; other site 911045009816 Leucine rich repeat; Region: LRR_8; pfam13855 911045009817 Leucine rich repeat; Region: LRR_8; pfam13855 911045009818 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045009819 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 911045009820 conserved cys residue [active] 911045009821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045009822 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 911045009823 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 911045009824 conserved cys residue [active] 911045009825 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 911045009826 CoenzymeA binding site [chemical binding]; other site 911045009827 subunit interaction site [polypeptide binding]; other site 911045009828 PHB binding site; other site 911045009829 enoyl-CoA hydratase; Validated; Region: PRK08139 911045009830 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045009831 substrate binding site [chemical binding]; other site 911045009832 oxyanion hole (OAH) forming residues; other site 911045009833 trimer interface [polypeptide binding]; other site 911045009834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045009835 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 911045009836 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 911045009837 homodimer interface [polypeptide binding]; other site 911045009838 substrate-cofactor binding pocket; other site 911045009839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045009840 catalytic residue [active] 911045009841 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 911045009842 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 911045009843 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 911045009844 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 911045009845 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 911045009846 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 911045009847 putative active site [active] 911045009848 putative metal binding site [ion binding]; other site 911045009849 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 911045009850 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045009851 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 911045009852 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 911045009853 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 911045009854 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 911045009855 SLBB domain; Region: SLBB; pfam10531 911045009856 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045009857 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 911045009858 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 911045009859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045009860 Bacterial sugar transferase; Region: Bac_transf; cl00939 911045009861 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 911045009862 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 911045009863 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 911045009864 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 911045009865 hypothetical protein; Provisional; Region: PRK06148 911045009866 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045009867 active site 911045009868 ATP binding site [chemical binding]; other site 911045009869 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045009870 inhibitor-cofactor binding pocket; inhibition site 911045009871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045009872 catalytic residue [active] 911045009873 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045009874 Helix-turn-helix domains; Region: HTH; cl00088 911045009875 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 911045009876 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 911045009877 DNA binding residues [nucleotide binding] 911045009878 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 911045009879 IHF dimer interface [polypeptide binding]; other site 911045009880 IHF - DNA interface [nucleotide binding]; other site 911045009881 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 911045009882 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 911045009883 dimer interface [polypeptide binding]; other site 911045009884 active site 911045009885 CoA binding pocket [chemical binding]; other site 911045009886 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 911045009887 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 911045009888 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 911045009889 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 911045009890 Protein of unknown function, DUF417; Region: DUF417; cl01162 911045009891 Protein of unknown function, DUF417; Region: DUF417; cl01162 911045009892 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045009893 active site 911045009894 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 911045009895 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 911045009896 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 911045009897 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 911045009898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045009899 putative substrate translocation pore; other site 911045009900 thiamine monophosphate kinase; Provisional; Region: PRK05731 911045009901 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 911045009902 ATP binding site [chemical binding]; other site 911045009903 dimerization interface [polypeptide binding]; other site 911045009904 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 911045009905 putative RNA binding site [nucleotide binding]; other site 911045009906 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 911045009907 homopentamer interface [polypeptide binding]; other site 911045009908 active site 911045009909 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 911045009910 Lumazine binding domain; Region: Lum_binding; pfam00677 911045009911 Lumazine binding domain; Region: Lum_binding; pfam00677 911045009912 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 911045009913 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 911045009914 catalytic motif [active] 911045009915 Zn binding site [ion binding]; other site 911045009916 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 911045009917 ATP cone domain; Region: ATP-cone; pfam03477 911045009918 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 911045009919 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 911045009920 dimer interface [polypeptide binding]; other site 911045009921 glycine-pyridoxal phosphate binding site [chemical binding]; other site 911045009922 active site 911045009923 folate binding site [chemical binding]; other site 911045009924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 911045009925 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 911045009926 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 911045009927 Helix-turn-helix domains; Region: HTH; cl00088 911045009928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045009929 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 911045009930 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 911045009931 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045009932 substrate binding site [chemical binding]; other site 911045009933 oxyanion hole (OAH) forming residues; other site 911045009934 trimer interface [polypeptide binding]; other site 911045009935 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 911045009936 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045009937 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 911045009938 substrate binding pocket [chemical binding]; other site 911045009939 FAD binding site [chemical binding]; other site 911045009940 catalytic base [active] 911045009941 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 911045009942 dimer interface [polypeptide binding]; other site 911045009943 allosteric magnesium binding site [ion binding]; other site 911045009944 active site 911045009945 aspartate-rich active site metal binding site; other site 911045009946 Schiff base residues; other site 911045009947 threonine dehydratase; Provisional; Region: PRK07334 911045009948 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 911045009949 tetramer interface [polypeptide binding]; other site 911045009950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045009951 catalytic residue [active] 911045009952 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 911045009953 RDD family; Region: RDD; cl00746 911045009954 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 911045009955 transmembrane helices; other site 911045009956 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 911045009957 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 911045009958 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 911045009959 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 911045009960 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 911045009961 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045009962 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 911045009963 ligand binding site [chemical binding]; other site 911045009964 active site 911045009965 Uncharacterized conserved protein [Function unknown]; Region: COG1432 911045009966 LabA_like proteins; Region: LabA; cd10911 911045009967 putative metal binding site [ion binding]; other site 911045009968 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 911045009969 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 911045009970 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 911045009971 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 911045009972 synthetase active site [active] 911045009973 NTP binding site [chemical binding]; other site 911045009974 metal binding site [ion binding]; metal-binding site 911045009975 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 911045009976 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 911045009977 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 911045009978 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 911045009979 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 911045009980 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 911045009981 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 911045009982 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 911045009983 Catalytic site [active] 911045009984 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 911045009985 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 911045009986 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 911045009987 dimerization interface [polypeptide binding]; other site 911045009988 active site 911045009989 metal binding site [ion binding]; metal-binding site 911045009990 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 911045009991 dsRNA binding site [nucleotide binding]; other site 911045009992 GTPase Era; Reviewed; Region: era; PRK00089 911045009993 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 911045009994 G1 box; other site 911045009995 GTP/Mg2+ binding site [chemical binding]; other site 911045009996 Switch I region; other site 911045009997 G2 box; other site 911045009998 Switch II region; other site 911045009999 G3 box; other site 911045010000 G4 box; other site 911045010001 G5 box; other site 911045010002 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 911045010003 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 911045010004 Recombination protein O N terminal; Region: RecO_N; cl15812 911045010005 Recombination protein O C terminal; Region: RecO_C; pfam02565 911045010006 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 911045010007 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 911045010008 CAP-like domain; other site 911045010009 active site 911045010010 primary dimer interface [polypeptide binding]; other site 911045010011 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 911045010012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045010013 active site 911045010014 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 911045010015 SmpB-tmRNA interface; other site 911045010016 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 911045010017 dihydrodipicolinate synthase; Region: dapA; TIGR00674 911045010018 dimer interface [polypeptide binding]; other site 911045010019 active site 911045010020 catalytic residue [active] 911045010021 Tetratricopeptide repeat; Region: TPR_12; pfam13424 911045010022 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 911045010023 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 911045010024 N-acetyl-D-glucosamine binding site [chemical binding]; other site 911045010025 catalytic residue [active] 911045010026 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045010027 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045010028 Porin subfamily; Region: Porin_2; pfam02530 911045010029 Porin subfamily; Region: Porin_2; pfam02530 911045010030 Porin subfamily; Region: Porin_2; pfam02530 911045010031 Porin subfamily; Region: Porin_2; pfam02530 911045010032 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 911045010033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045010034 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 911045010035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045010036 NMT1-like family; Region: NMT1_2; cl15260 911045010037 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 911045010038 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 911045010039 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 911045010040 Walker A/P-loop; other site 911045010041 ATP binding site [chemical binding]; other site 911045010042 Q-loop/lid; other site 911045010043 ABC transporter signature motif; other site 911045010044 Walker B; other site 911045010045 D-loop; other site 911045010046 H-loop/switch region; other site 911045010047 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045010048 Coenzyme A binding pocket [chemical binding]; other site 911045010049 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 911045010050 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 911045010051 Helix-turn-helix domains; Region: HTH; cl00088 911045010052 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 911045010053 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045010054 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 911045010055 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045010056 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 911045010057 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 911045010058 Walker A/P-loop; other site 911045010059 ATP binding site [chemical binding]; other site 911045010060 Q-loop/lid; other site 911045010061 ABC transporter signature motif; other site 911045010062 Walker B; other site 911045010063 D-loop; other site 911045010064 H-loop/switch region; other site 911045010065 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 911045010066 ABC-2 type transporter; Region: ABC2_membrane; cl11417 911045010067 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 911045010068 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 911045010069 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 911045010070 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 911045010071 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045010072 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045010073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010074 dimer interface [polypeptide binding]; other site 911045010075 conserved gate region; other site 911045010076 putative PBP binding loops; other site 911045010077 ABC-ATPase subunit interface; other site 911045010078 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045010079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010080 dimer interface [polypeptide binding]; other site 911045010081 conserved gate region; other site 911045010082 putative PBP binding loops; other site 911045010083 ABC-ATPase subunit interface; other site 911045010084 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 911045010085 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 911045010086 active sites [active] 911045010087 tetramer interface [polypeptide binding]; other site 911045010088 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045010089 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045010090 Walker A/P-loop; other site 911045010091 ATP binding site [chemical binding]; other site 911045010092 Q-loop/lid; other site 911045010093 ABC transporter signature motif; other site 911045010094 Walker B; other site 911045010095 D-loop; other site 911045010096 H-loop/switch region; other site 911045010097 TOBE domain; Region: TOBE_2; cl01440 911045010098 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045010099 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 911045010100 substrate binding site [chemical binding]; other site 911045010101 ATP binding site [chemical binding]; other site 911045010102 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045010103 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045010104 DNA binding site [nucleotide binding] 911045010105 domain linker motif; other site 911045010106 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 911045010107 ligand binding site [chemical binding]; other site 911045010108 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045010109 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045010110 substrate binding pocket [chemical binding]; other site 911045010111 membrane-bound complex binding site; other site 911045010112 hinge residues; other site 911045010113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010114 dimer interface [polypeptide binding]; other site 911045010115 conserved gate region; other site 911045010116 putative PBP binding loops; other site 911045010117 ABC-ATPase subunit interface; other site 911045010118 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 911045010119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045010120 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045010121 putative aminotransferase; Validated; Region: PRK07480 911045010122 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045010123 inhibitor-cofactor binding pocket; inhibition site 911045010124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045010125 catalytic residue [active] 911045010126 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045010127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045010128 DNA-binding site [nucleotide binding]; DNA binding site 911045010129 FCD domain; Region: FCD; cl11656 911045010130 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 911045010131 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045010132 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 911045010133 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045010134 Walker A/P-loop; other site 911045010135 ATP binding site [chemical binding]; other site 911045010136 Q-loop/lid; other site 911045010137 ABC transporter signature motif; other site 911045010138 Walker B; other site 911045010139 D-loop; other site 911045010140 H-loop/switch region; other site 911045010141 TOBE domain; Region: TOBE_2; cl01440 911045010142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010143 dimer interface [polypeptide binding]; other site 911045010144 conserved gate region; other site 911045010145 putative PBP binding loops; other site 911045010146 ABC-ATPase subunit interface; other site 911045010147 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045010148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010149 dimer interface [polypeptide binding]; other site 911045010150 conserved gate region; other site 911045010151 putative PBP binding loops; other site 911045010152 ABC-ATPase subunit interface; other site 911045010153 Arginase family; Region: Arginase; cl00306 911045010154 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 911045010155 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 911045010156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045010157 NAD(P) binding site [chemical binding]; other site 911045010158 active site 911045010159 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045010160 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 911045010161 putative NAD(P) binding site [chemical binding]; other site 911045010162 active site 911045010163 putative substrate binding site [chemical binding]; other site 911045010164 bile acid transporter; Region: bass; TIGR00841 911045010165 Membrane transport protein; Region: Mem_trans; cl09117 911045010166 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 911045010167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045010168 Helix-turn-helix domains; Region: HTH; cl00088 911045010169 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045010170 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045010171 DctM-like transporters; Region: DctM; pfam06808 911045010172 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045010173 enoyl-CoA hydratase; Provisional; Region: PRK07511 911045010174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045010175 substrate binding site [chemical binding]; other site 911045010176 oxyanion hole (OAH) forming residues; other site 911045010177 trimer interface [polypeptide binding]; other site 911045010178 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 911045010179 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 911045010180 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 911045010181 active site 911045010182 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 911045010183 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045010184 active site 911045010185 Transcriptional regulator [Transcription]; Region: IclR; COG1414 911045010186 Helix-turn-helix domains; Region: HTH; cl00088 911045010187 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045010188 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 911045010189 Walker A/P-loop; other site 911045010190 ATP binding site [chemical binding]; other site 911045010191 Q-loop/lid; other site 911045010192 ABC transporter signature motif; other site 911045010193 Walker B; other site 911045010194 D-loop; other site 911045010195 H-loop/switch region; other site 911045010196 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 911045010197 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 911045010198 Walker A/P-loop; other site 911045010199 ATP binding site [chemical binding]; other site 911045010200 Q-loop/lid; other site 911045010201 ABC transporter signature motif; other site 911045010202 Walker B; other site 911045010203 D-loop; other site 911045010204 H-loop/switch region; other site 911045010205 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045010206 TM-ABC transporter signature motif; other site 911045010207 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045010208 TM-ABC transporter signature motif; other site 911045010209 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 911045010210 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 911045010211 putative ligand binding site [chemical binding]; other site 911045010212 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045010213 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 911045010214 FHIPEP family; Region: FHIPEP; pfam00771 911045010215 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045010216 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045010217 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 911045010218 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 911045010219 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 911045010220 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 911045010221 FliP family; Region: FliP; cl00593 911045010222 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 911045010223 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 911045010224 type III secretion system ATPase; Provisional; Region: PRK06936 911045010225 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 911045010226 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 911045010227 Walker A motif/ATP binding site; other site 911045010228 Walker B motif; other site 911045010229 type III secretion system protein; Reviewed; Region: PRK06937 911045010230 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 911045010231 Type III secretion needle MxiH like; Region: MxiH; cl09641 911045010232 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 911045010233 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 911045010234 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 911045010235 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 911045010236 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 911045010237 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 911045010238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045010239 TPR motif; other site 911045010240 binding surface 911045010241 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 911045010242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045010243 TPR motif; other site 911045010244 binding surface 911045010245 HrpJ-like domain; Region: HrpJ; cl15454 911045010246 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 911045010247 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045010248 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045010249 ligand binding site [chemical binding]; other site 911045010250 flexible hinge region; other site 911045010251 Helix-turn-helix domains; Region: HTH; cl00088 911045010252 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 911045010253 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010254 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010255 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010256 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010257 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010258 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010259 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010260 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010261 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 911045010262 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045010263 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045010264 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045010265 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421 911045010266 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 911045010267 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045010268 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 911045010269 Walker A/P-loop; other site 911045010270 ATP binding site [chemical binding]; other site 911045010271 Q-loop/lid; other site 911045010272 ABC transporter signature motif; other site 911045010273 Walker B; other site 911045010274 D-loop; other site 911045010275 H-loop/switch region; other site 911045010276 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 911045010277 DctM-like transporters; Region: DctM; pfam06808 911045010278 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045010279 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045010280 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045010281 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045010282 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 911045010283 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 911045010284 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 911045010285 putative active site [active] 911045010286 Predicted amidohydrolase [General function prediction only]; Region: COG0388 911045010287 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 911045010288 active site 911045010289 catalytic triad [active] 911045010290 dimer interface [polypeptide binding]; other site 911045010291 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045010292 enoyl-CoA hydratase; Provisional; Region: PRK09245 911045010293 substrate binding site [chemical binding]; other site 911045010294 oxyanion hole (OAH) forming residues; other site 911045010295 trimer interface [polypeptide binding]; other site 911045010296 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 911045010297 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 911045010298 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045010299 catalytic loop [active] 911045010300 iron binding site [ion binding]; other site 911045010301 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 911045010302 4Fe-4S binding domain; Region: Fer4; cl02805 911045010303 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 911045010304 [4Fe-4S] binding site [ion binding]; other site 911045010305 molybdopterin cofactor binding site; other site 911045010306 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 911045010307 molybdopterin cofactor binding site; other site 911045010308 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 911045010309 putative dimer interface [polypeptide binding]; other site 911045010310 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 911045010311 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 911045010312 SLBB domain; Region: SLBB; pfam10531 911045010313 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 911045010314 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 911045010315 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 911045010316 putative dimer interface [polypeptide binding]; other site 911045010317 [2Fe-2S] cluster binding site [ion binding]; other site 911045010318 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045010319 Helix-turn-helix domains; Region: HTH; cl00088 911045010320 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045010321 dimerization interface [polypeptide binding]; other site 911045010322 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 911045010323 EamA-like transporter family; Region: EamA; cl01037 911045010324 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 911045010325 Helix-turn-helix domains; Region: HTH; cl00088 911045010326 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045010327 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 911045010328 Sulfatase; Region: Sulfatase; cl10460 911045010329 beta-lactamase TEM; Provisional; Region: PRK15442 911045010330 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045010331 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045010332 Helix-turn-helix domains; Region: HTH; cl00088 911045010333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045010334 dimerization interface [polypeptide binding]; other site 911045010335 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 911045010336 Predicted membrane protein [Function unknown]; Region: COG1289 911045010337 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 911045010338 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 911045010339 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045010340 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045010341 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 911045010342 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 911045010343 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 911045010344 catalytic residues [active] 911045010345 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 911045010346 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 911045010347 C-terminal domain interface [polypeptide binding]; other site 911045010348 GSH binding site (G-site) [chemical binding]; other site 911045010349 dimer interface [polypeptide binding]; other site 911045010350 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 911045010351 N-terminal domain interface [polypeptide binding]; other site 911045010352 putative dimer interface [polypeptide binding]; other site 911045010353 active site 911045010354 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045010355 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045010356 Coenzyme A binding pocket [chemical binding]; other site 911045010357 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 911045010358 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045010359 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 911045010360 active site 911045010361 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045010362 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 911045010363 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 911045010364 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045010365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045010366 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 911045010367 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 911045010368 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 911045010369 GatB domain; Region: GatB_Yqey; cl11497 911045010370 Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; cl01566 911045010371 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045010372 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045010373 dimerization interface [polypeptide binding]; other site 911045010374 putative DNA binding site [nucleotide binding]; other site 911045010375 putative Zn2+ binding site [ion binding]; other site 911045010376 laccase, plant; Region: laccase; TIGR03389 911045010377 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045010378 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045010379 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045010380 Predicted dehydrogenase [General function prediction only]; Region: COG0579 911045010381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045010382 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 911045010383 catalytic triad [active] 911045010384 conserved cis-peptide bond; other site 911045010385 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 911045010386 NADH(P)-binding; Region: NAD_binding_10; pfam13460 911045010387 putative NAD(P) binding site [chemical binding]; other site 911045010388 active site 911045010389 DoxX-like family; Region: DoxX_3; pfam13781 911045010390 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 911045010391 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 911045010392 Amidase; Region: Amidase; cl11426 911045010393 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 911045010394 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045010395 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 911045010396 conserved cys residue [active] 911045010397 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045010398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045010399 Helix-turn-helix domains; Region: HTH; cl00088 911045010400 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 911045010401 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 911045010402 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045010403 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 911045010404 ligand binding site [chemical binding]; other site 911045010405 active site 911045010406 UGI interface [polypeptide binding]; other site 911045010407 catalytic site [active] 911045010408 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 911045010409 Membrane transport protein; Region: Mem_trans; cl09117 911045010410 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045010411 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045010412 active site 911045010413 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 911045010414 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 911045010415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045010416 dihydroorotase; Validated; Region: PRK09059 911045010417 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045010418 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 911045010419 active site 911045010420 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 911045010421 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 911045010422 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 911045010423 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 911045010424 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 911045010425 active site 911045010426 interdomain interaction site; other site 911045010427 putative metal-binding site [ion binding]; other site 911045010428 nucleotide binding site [chemical binding]; other site 911045010429 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 911045010430 domain I; other site 911045010431 DNA binding groove [nucleotide binding] 911045010432 phosphate binding site [ion binding]; other site 911045010433 domain II; other site 911045010434 domain III; other site 911045010435 nucleotide binding site [chemical binding]; other site 911045010436 catalytic site [active] 911045010437 domain IV; other site 911045010438 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 911045010439 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 911045010440 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 911045010441 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 911045010442 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 911045010443 ribonuclease R; Region: RNase_R; TIGR02063 911045010444 RNB domain; Region: RNB; pfam00773 911045010445 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 911045010446 RNA binding site [nucleotide binding]; other site 911045010447 Protein of unknown function (DUF983); Region: DUF983; cl02211 911045010448 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045010449 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045010450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045010451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045010452 putative substrate translocation pore; other site 911045010453 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 911045010454 Response regulator receiver domain; Region: Response_reg; pfam00072 911045010455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045010456 active site 911045010457 phosphorylation site [posttranslational modification] 911045010458 intermolecular recognition site; other site 911045010459 dimerization interface [polypeptide binding]; other site 911045010460 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 911045010461 hypothetical protein; Provisional; Region: 30.2; PHA02597 911045010462 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 911045010463 DNA polymerase IV; Provisional; Region: PRK02794 911045010464 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 911045010465 active site 911045010466 DNA binding site [nucleotide binding] 911045010467 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 911045010468 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 911045010469 homotrimer interaction site [polypeptide binding]; other site 911045010470 putative active site [active] 911045010471 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 911045010472 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 911045010473 active site 911045010474 catalytic site [active] 911045010475 Protein of unknown function, DUF482; Region: DUF482; pfam04339 911045010476 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045010477 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 911045010478 HIT family signature motif; other site 911045010479 catalytic residue [active] 911045010480 YoaP-like; Region: YoaP; pfam14268 911045010481 AzlC protein; Region: AzlC; cl00570 911045010482 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 911045010483 Clp amino terminal domain; Region: Clp_N; pfam02861 911045010484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045010485 Walker A motif; other site 911045010486 ATP binding site [chemical binding]; other site 911045010487 Walker B motif; other site 911045010488 arginine finger; other site 911045010489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045010490 Walker A motif; other site 911045010491 ATP binding site [chemical binding]; other site 911045010492 Walker B motif; other site 911045010493 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 911045010494 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 911045010495 Phasin protein; Region: Phasin_2; cl11491 911045010496 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 911045010497 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045010498 Sporulation related domain; Region: SPOR; cl10051 911045010499 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 911045010500 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 911045010501 HSP70 interaction site [polypeptide binding]; other site 911045010502 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 911045010503 pantoate--beta-alanine ligase; Region: panC; TIGR00018 911045010504 Pantoate-beta-alanine ligase; Region: PanC; cd00560 911045010505 active site 911045010506 ATP-binding site [chemical binding]; other site 911045010507 pantoate-binding site; other site 911045010508 HXXH motif; other site 911045010509 Protein of unknown function (DUF1489); Region: DUF1489; cl11570 911045010510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045010511 Helix-turn-helix domains; Region: HTH; cl00088 911045010512 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 911045010513 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 911045010514 putative NAD(P) binding site [chemical binding]; other site 911045010515 GAF domain; Region: GAF_2; pfam13185 911045010516 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 911045010517 cyclase homology domain; Region: CHD; cd07302 911045010518 nucleotidyl binding site; other site 911045010519 metal binding site [ion binding]; metal-binding site 911045010520 dimer interface [polypeptide binding]; other site 911045010521 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 911045010522 thiamine phosphate binding site [chemical binding]; other site 911045010523 active site 911045010524 pyrophosphate binding site [ion binding]; other site 911045010525 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 911045010526 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 911045010527 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 911045010528 oligomer interface [polypeptide binding]; other site 911045010529 active site residues [active] 911045010530 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045010531 metal binding site [ion binding]; metal-binding site 911045010532 active site 911045010533 I-site; other site 911045010534 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045010535 ACT domain; Region: ACT_3; pfam10000 911045010536 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 911045010537 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 911045010538 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045010539 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 911045010540 putative metal binding site [ion binding]; other site 911045010541 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 911045010542 MgtE intracellular N domain; Region: MgtE_N; cl15244 911045010543 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 911045010544 Divalent cation transporter; Region: MgtE; cl00786 911045010545 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 911045010546 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 911045010547 Acylphosphatase; Region: Acylphosphatase; cl00551 911045010548 EamA-like transporter family; Region: EamA; cl01037 911045010549 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 911045010550 putative active site pocket [active] 911045010551 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 911045010552 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045010553 motif II; other site 911045010554 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 911045010555 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045010556 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045010557 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 911045010558 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 911045010559 carboxyltransferase (CT) interaction site; other site 911045010560 biotinylation site [posttranslational modification]; other site 911045010561 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 911045010562 homooctamer interface [polypeptide binding]; other site 911045010563 active site 911045010564 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 911045010565 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 911045010566 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 911045010567 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 911045010568 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 911045010569 heme binding site [chemical binding]; other site 911045010570 ferroxidase pore; other site 911045010571 ferroxidase diiron center [ion binding]; other site 911045010572 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 911045010573 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 911045010574 heme binding site [chemical binding]; other site 911045010575 ferroxidase pore; other site 911045010576 ferroxidase diiron center [ion binding]; other site 911045010577 ATP12 chaperone protein; Region: ATP12; cl02228 911045010578 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 911045010579 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045010580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045010581 motif II; other site 911045010582 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 911045010583 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 911045010584 active site 911045010585 CrcB-like protein; Region: CRCB; cl09114 911045010586 patatin-related protein; Region: TIGR03607 911045010587 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 911045010588 recombination factor protein RarA; Reviewed; Region: PRK13342 911045010589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045010590 Walker A motif; other site 911045010591 ATP binding site [chemical binding]; other site 911045010592 Walker B motif; other site 911045010593 arginine finger; other site 911045010594 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 911045010595 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 911045010596 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 911045010597 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 911045010598 protein binding site [polypeptide binding]; other site 911045010599 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 911045010600 protein binding site [polypeptide binding]; other site 911045010601 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045010602 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045010603 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045010604 dimer interface [polypeptide binding]; other site 911045010605 putative CheW interface [polypeptide binding]; other site 911045010606 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 911045010607 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 911045010608 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 911045010609 alphaNTD - beta interaction site [polypeptide binding]; other site 911045010610 alphaNTD homodimer interface [polypeptide binding]; other site 911045010611 alphaNTD - beta' interaction site [polypeptide binding]; other site 911045010612 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 911045010613 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 911045010614 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 911045010615 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 911045010616 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 911045010617 adenylate kinase; Reviewed; Region: adk; PRK00279 911045010618 AMP-binding site [chemical binding]; other site 911045010619 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 911045010620 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 911045010621 SecY translocase; Region: SecY; pfam00344 911045010622 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 911045010623 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 911045010624 23S rRNA binding site [nucleotide binding]; other site 911045010625 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 911045010626 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 911045010627 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 911045010628 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 911045010629 23S rRNA interface [nucleotide binding]; other site 911045010630 L21e interface [polypeptide binding]; other site 911045010631 5S rRNA interface [nucleotide binding]; other site 911045010632 L27 interface [polypeptide binding]; other site 911045010633 L5 interface [polypeptide binding]; other site 911045010634 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 911045010635 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 911045010636 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 911045010637 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 911045010638 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 911045010639 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 911045010640 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 911045010641 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 911045010642 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 911045010643 KOW motif; Region: KOW; cl00354 911045010644 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 911045010645 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 911045010646 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 911045010647 23S rRNA interface [nucleotide binding]; other site 911045010648 putative translocon interaction site; other site 911045010649 signal recognition particle (SRP54) interaction site; other site 911045010650 L23 interface [polypeptide binding]; other site 911045010651 trigger factor interaction site; other site 911045010652 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 911045010653 23S rRNA interface [nucleotide binding]; other site 911045010654 5S rRNA interface [nucleotide binding]; other site 911045010655 putative antibiotic binding site [chemical binding]; other site 911045010656 L25 interface [polypeptide binding]; other site 911045010657 L27 interface [polypeptide binding]; other site 911045010658 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 911045010659 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 911045010660 G-X-X-G motif; other site 911045010661 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 911045010662 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 911045010663 putative translocon binding site; other site 911045010664 protein-rRNA interface [nucleotide binding]; other site 911045010665 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 911045010666 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 911045010667 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 911045010668 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 911045010669 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 911045010670 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 911045010671 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 911045010672 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 911045010673 elongation factor Tu; Reviewed; Region: PRK00049 911045010674 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 911045010675 G1 box; other site 911045010676 GEF interaction site [polypeptide binding]; other site 911045010677 GTP/Mg2+ binding site [chemical binding]; other site 911045010678 Switch I region; other site 911045010679 G2 box; other site 911045010680 G3 box; other site 911045010681 Switch II region; other site 911045010682 G4 box; other site 911045010683 G5 box; other site 911045010684 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 911045010685 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 911045010686 Antibiotic Binding Site [chemical binding]; other site 911045010687 elongation factor G; Reviewed; Region: PRK00007 911045010688 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 911045010689 G1 box; other site 911045010690 putative GEF interaction site [polypeptide binding]; other site 911045010691 GTP/Mg2+ binding site [chemical binding]; other site 911045010692 Switch I region; other site 911045010693 G2 box; other site 911045010694 G3 box; other site 911045010695 Switch II region; other site 911045010696 G4 box; other site 911045010697 G5 box; other site 911045010698 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 911045010699 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 911045010700 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 911045010701 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 911045010702 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 911045010703 S17 interaction site [polypeptide binding]; other site 911045010704 S8 interaction site; other site 911045010705 16S rRNA interaction site [nucleotide binding]; other site 911045010706 streptomycin interaction site [chemical binding]; other site 911045010707 23S rRNA interaction site [nucleotide binding]; other site 911045010708 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 911045010709 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 911045010710 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 911045010711 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 911045010712 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 911045010713 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 911045010714 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 911045010715 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 911045010716 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 911045010717 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 911045010718 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 911045010719 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 911045010720 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 911045010721 DNA binding site [nucleotide binding] 911045010722 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 911045010723 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 911045010724 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 911045010725 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 911045010726 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 911045010727 RPB12 interaction site [polypeptide binding]; other site 911045010728 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 911045010729 RPB11 interaction site [polypeptide binding]; other site 911045010730 RPB12 interaction site [polypeptide binding]; other site 911045010731 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 911045010732 RPB3 interaction site [polypeptide binding]; other site 911045010733 RPB1 interaction site [polypeptide binding]; other site 911045010734 RPB11 interaction site [polypeptide binding]; other site 911045010735 RPB10 interaction site [polypeptide binding]; other site 911045010736 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 911045010737 core dimer interface [polypeptide binding]; other site 911045010738 peripheral dimer interface [polypeptide binding]; other site 911045010739 L10 interface [polypeptide binding]; other site 911045010740 L11 interface [polypeptide binding]; other site 911045010741 putative EF-Tu interaction site [polypeptide binding]; other site 911045010742 putative EF-G interaction site [polypeptide binding]; other site 911045010743 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 911045010744 23S rRNA interface [nucleotide binding]; other site 911045010745 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 911045010746 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 911045010747 mRNA/rRNA interface [nucleotide binding]; other site 911045010748 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 911045010749 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 911045010750 23S rRNA interface [nucleotide binding]; other site 911045010751 L7/L12 interface [polypeptide binding]; other site 911045010752 putative thiostrepton binding site; other site 911045010753 L25 interface [polypeptide binding]; other site 911045010754 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 911045010755 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 911045010756 putative homodimer interface [polypeptide binding]; other site 911045010757 KOW motif; Region: KOW; cl00354 911045010758 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 911045010759 elongation factor Tu; Reviewed; Region: PRK00049 911045010760 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 911045010761 G1 box; other site 911045010762 GEF interaction site [polypeptide binding]; other site 911045010763 GTP/Mg2+ binding site [chemical binding]; other site 911045010764 Switch I region; other site 911045010765 G2 box; other site 911045010766 G3 box; other site 911045010767 Switch II region; other site 911045010768 G4 box; other site 911045010769 G5 box; other site 911045010770 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 911045010771 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 911045010772 Antibiotic Binding Site [chemical binding]; other site 911045010773 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 911045010774 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 911045010775 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 911045010776 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 911045010777 active site 911045010778 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045010779 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045010780 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045010781 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045010782 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045010783 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045010784 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045010785 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045010786 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045010787 hypothetical protein; Validated; Region: PRK07078 911045010788 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 911045010789 active site 911045010790 metal binding site [ion binding]; metal-binding site 911045010791 interdomain interaction site; other site 911045010792 hypothetical protein; Validated; Region: PRK07078 911045010793 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045010794 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 911045010795 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 911045010796 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 911045010797 active site 911045010798 intersubunit interface [polypeptide binding]; other site 911045010799 catalytic residue [active] 911045010800 Major royal jelly protein; Region: MRJP; pfam03022 911045010801 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045010802 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 911045010803 substrate binding site [chemical binding]; other site 911045010804 ATP binding site [chemical binding]; other site 911045010805 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 911045010806 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 911045010807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045010808 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045010809 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045010810 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045010811 DctM-like transporters; Region: DctM; pfam06808 911045010812 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045010813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045010814 DNA-binding site [nucleotide binding]; DNA binding site 911045010815 FCD domain; Region: FCD; cl11656 911045010816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045010817 Helix-turn-helix domains; Region: HTH; cl00088 911045010818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045010819 dimerization interface [polypeptide binding]; other site 911045010820 Major royal jelly protein; Region: MRJP; pfam03022 911045010821 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 911045010822 putative catalytic residue [active] 911045010823 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 911045010824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010825 dimer interface [polypeptide binding]; other site 911045010826 conserved gate region; other site 911045010827 putative PBP binding loops; other site 911045010828 ABC-ATPase subunit interface; other site 911045010829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010830 dimer interface [polypeptide binding]; other site 911045010831 conserved gate region; other site 911045010832 putative PBP binding loops; other site 911045010833 ABC-ATPase subunit interface; other site 911045010834 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 911045010835 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045010836 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 911045010837 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 911045010838 active site 911045010839 catalytic site [active] 911045010840 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045010841 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045010842 DNA binding site [nucleotide binding] 911045010843 domain linker motif; other site 911045010844 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 911045010845 ligand binding site [chemical binding]; other site 911045010846 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045010847 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045010848 Walker A/P-loop; other site 911045010849 ATP binding site [chemical binding]; other site 911045010850 Q-loop/lid; other site 911045010851 ABC transporter signature motif; other site 911045010852 Walker B; other site 911045010853 D-loop; other site 911045010854 H-loop/switch region; other site 911045010855 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 911045010856 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 911045010857 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045010858 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045010859 Walker A/P-loop; other site 911045010860 ATP binding site [chemical binding]; other site 911045010861 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 911045010862 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 911045010863 putative active site [active] 911045010864 putative metal-binding site [ion binding]; other site 911045010865 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045010866 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 911045010867 DNA binding site [nucleotide binding] 911045010868 Int/Topo IB signature motif; other site 911045010869 active site 911045010870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 911045010871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045010872 dimer interface [polypeptide binding]; other site 911045010873 phosphorylation site [posttranslational modification] 911045010874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045010875 ATP binding site [chemical binding]; other site 911045010876 Mg2+ binding site [ion binding]; other site 911045010877 G-X-G motif; other site 911045010878 Response regulator receiver domain; Region: Response_reg; pfam00072 911045010879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045010880 active site 911045010881 phosphorylation site [posttranslational modification] 911045010882 intermolecular recognition site; other site 911045010883 dimerization interface [polypeptide binding]; other site 911045010884 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 911045010885 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 911045010886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045010887 active site 911045010888 phosphorylation site [posttranslational modification] 911045010889 intermolecular recognition site; other site 911045010890 dimerization interface [polypeptide binding]; other site 911045010891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045010892 DNA binding site [nucleotide binding] 911045010893 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 911045010894 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 911045010895 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 911045010896 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 911045010897 molybdopterin cofactor binding site [chemical binding]; other site 911045010898 substrate binding site [chemical binding]; other site 911045010899 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 911045010900 molybdopterin cofactor binding site; other site 911045010901 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 911045010902 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 911045010903 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 911045010904 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 911045010905 FMN binding site [chemical binding]; other site 911045010906 substrate binding site [chemical binding]; other site 911045010907 putative catalytic residue [active] 911045010908 Helix-turn-helix domains; Region: HTH; cl00088 911045010909 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045010910 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045010911 DNA binding site [nucleotide binding] 911045010912 domain linker motif; other site 911045010913 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 911045010914 ligand binding site [chemical binding]; other site 911045010915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045010916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010917 dimer interface [polypeptide binding]; other site 911045010918 conserved gate region; other site 911045010919 putative PBP binding loops; other site 911045010920 ABC-ATPase subunit interface; other site 911045010921 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045010922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010923 dimer interface [polypeptide binding]; other site 911045010924 conserved gate region; other site 911045010925 putative PBP binding loops; other site 911045010926 ABC-ATPase subunit interface; other site 911045010927 alpha-glucosidase; Provisional; Region: PRK10137 911045010928 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 911045010929 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045010930 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045010931 Walker A/P-loop; other site 911045010932 ATP binding site [chemical binding]; other site 911045010933 Q-loop/lid; other site 911045010934 ABC transporter signature motif; other site 911045010935 Walker B; other site 911045010936 D-loop; other site 911045010937 H-loop/switch region; other site 911045010938 TOBE domain; Region: TOBE_2; cl01440 911045010939 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045010940 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 911045010941 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 911045010942 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; cl15419 911045010943 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 911045010944 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 911045010945 Flavin Reductases; Region: FlaRed; cl00801 911045010946 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 911045010947 putative FMN binding site [chemical binding]; other site 911045010948 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045010949 putative acyl-acceptor binding pocket; other site 911045010950 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 911045010951 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 911045010952 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 911045010953 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 911045010954 active site 911045010955 dimer interface [polypeptide binding]; other site 911045010956 motif 1; other site 911045010957 motif 2; other site 911045010958 motif 3; other site 911045010959 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 911045010960 anticodon binding site; other site 911045010961 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 911045010962 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 911045010963 hypothetical protein; Provisional; Region: PRK11281 911045010964 Haemolytic domain; Region: Haemolytic; cl00506 911045010965 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 911045010966 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 911045010967 trimerization site [polypeptide binding]; other site 911045010968 active site 911045010969 GTP cyclohydrolase I; Provisional; Region: PLN03044 911045010970 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 911045010971 active site 911045010972 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 911045010973 hypothetical protein; Provisional; Region: PRK10279 911045010974 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 911045010975 nucleophile elbow; other site 911045010976 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 911045010977 FOG: CBS domain [General function prediction only]; Region: COG0517 911045010978 Rhomboid family; Region: Rhomboid; cl11446 911045010979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 911045010980 PAS domain; Region: PAS_5; pfam07310 911045010981 PilZ domain; Region: PilZ; cl01260 911045010982 PilZ domain; Region: PilZ; cl01260 911045010983 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 911045010984 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 911045010985 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 911045010986 trimer interface [polypeptide binding]; other site 911045010987 putative metal binding site [ion binding]; other site 911045010988 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 911045010989 serine acetyltransferase; Provisional; Region: cysE; PRK11132 911045010990 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 911045010991 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 911045010992 trimer interface [polypeptide binding]; other site 911045010993 active site 911045010994 substrate binding site [chemical binding]; other site 911045010995 CoA binding site [chemical binding]; other site 911045010996 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045010997 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045010998 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045010999 Zinc-finger domain; Region: zf-CHCC; cl01821 911045011000 salicylate hydroxylase; Provisional; Region: PRK08163 911045011001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045011002 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 911045011003 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 911045011004 putative MPT binding site; other site 911045011005 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045011006 active site 911045011007 Sugar fermentation stimulation protein; Region: SfsA; cl00647 911045011008 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 911045011009 Cation transport protein; Region: TrkH; cl10514 911045011010 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 911045011011 Cation transport protein; Region: TrkH; cl10514 911045011012 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 911045011013 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 911045011014 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 911045011015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045011016 Helix-turn-helix domains; Region: HTH; cl00088 911045011017 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045011018 dimerization interface [polypeptide binding]; other site 911045011019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 911045011020 methionine aminopeptidase; Provisional; Region: PRK12318 911045011021 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 911045011022 active site 911045011023 hypothetical protein; Reviewed; Region: PRK00024 911045011024 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 911045011025 MPN+ (JAMM) motif; other site 911045011026 Zinc-binding site [ion binding]; other site 911045011027 CHASE4 domain; Region: CHASE4; cl01308 911045011028 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045011029 metal binding site [ion binding]; metal-binding site 911045011030 active site 911045011031 I-site; other site 911045011032 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045011033 ArgK protein; Region: ArgK; pfam03308 911045011034 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045011035 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045011036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045011037 G4 box; other site 911045011038 G5 box; other site 911045011039 pyruvate phosphate dikinase; Provisional; Region: PRK09279 911045011040 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 911045011041 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 911045011042 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 911045011043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045011044 binding surface 911045011045 TPR motif; other site 911045011046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045011047 binding surface 911045011048 TPR repeat; Region: TPR_11; pfam13414 911045011049 TPR motif; other site 911045011050 TPR repeat; Region: TPR_11; pfam13414 911045011051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045011052 binding surface 911045011053 Tetratricopeptide repeat; Region: TPR_16; pfam13432 911045011054 TPR motif; other site 911045011055 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 911045011056 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 911045011057 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 911045011058 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 911045011059 tetramer interface [polypeptide binding]; other site 911045011060 heme binding pocket [chemical binding]; other site 911045011061 NADPH binding site [chemical binding]; other site 911045011062 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 911045011063 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 911045011064 substrate binding pocket [chemical binding]; other site 911045011065 chain length determination region; other site 911045011066 substrate-Mg2+ binding site; other site 911045011067 catalytic residues [active] 911045011068 aspartate-rich region 1; other site 911045011069 active site lid residues [active] 911045011070 aspartate-rich region 2; other site 911045011071 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 911045011072 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 911045011073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045011074 S-adenosylmethionine binding site [chemical binding]; other site 911045011075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045011076 Walker A motif; other site 911045011077 ATP binding site [chemical binding]; other site 911045011078 Walker B motif; other site 911045011079 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 911045011080 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 911045011081 metal ion-dependent adhesion site (MIDAS); other site 911045011082 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 911045011083 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 911045011084 active site 1 [active] 911045011085 dimer interface [polypeptide binding]; other site 911045011086 hexamer interface [polypeptide binding]; other site 911045011087 active site 2 [active] 911045011088 Helix-turn-helix domains; Region: HTH; cl00088 911045011089 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045011090 dimerization interface [polypeptide binding]; other site 911045011091 Protease inhibitor Inh; Region: Inh; pfam02974 911045011092 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 911045011093 putative hydrophobic ligand binding site [chemical binding]; other site 911045011094 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 911045011095 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 911045011096 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 911045011097 dimerization interface [polypeptide binding]; other site 911045011098 ligand binding site [chemical binding]; other site 911045011099 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045011100 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 911045011101 Walker A/P-loop; other site 911045011102 ATP binding site [chemical binding]; other site 911045011103 Q-loop/lid; other site 911045011104 ABC transporter signature motif; other site 911045011105 Walker B; other site 911045011106 D-loop; other site 911045011107 H-loop/switch region; other site 911045011108 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 911045011109 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 911045011110 Walker A/P-loop; other site 911045011111 ATP binding site [chemical binding]; other site 911045011112 Q-loop/lid; other site 911045011113 ABC transporter signature motif; other site 911045011114 Walker B; other site 911045011115 D-loop; other site 911045011116 H-loop/switch region; other site 911045011117 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 911045011118 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 911045011119 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045011120 TM-ABC transporter signature motif; other site 911045011121 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045011122 TM-ABC transporter signature motif; other site 911045011123 Flavin Reductases; Region: FlaRed; cl00801 911045011124 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 911045011125 putative active site pocket [active] 911045011126 cleavage site 911045011127 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 911045011128 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045011129 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045011130 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045011131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045011132 Helix-turn-helix domains; Region: HTH; cl00088 911045011133 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 911045011134 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 911045011135 dimer interface [polypeptide binding]; other site 911045011136 PYR/PP interface [polypeptide binding]; other site 911045011137 TPP binding site [chemical binding]; other site 911045011138 substrate binding site [chemical binding]; other site 911045011139 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 911045011140 TPP-binding site; other site 911045011141 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 911045011142 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045011143 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045011144 putative DNA binding site [nucleotide binding]; other site 911045011145 putative Zn2+ binding site [ion binding]; other site 911045011146 Helix-turn-helix domains; Region: HTH; cl00088 911045011147 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 911045011148 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 911045011149 substrate binding site [chemical binding]; other site 911045011150 hexamer interface [polypeptide binding]; other site 911045011151 metal binding site [ion binding]; metal-binding site 911045011152 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 911045011153 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 911045011154 Domain of unknown function (DUF1476); Region: DUF1476; cl11571 911045011155 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 911045011156 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 911045011157 ATP binding site [chemical binding]; other site 911045011158 active site 911045011159 substrate binding site [chemical binding]; other site 911045011160 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 911045011161 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 911045011162 putative active site [active] 911045011163 catalytic triad [active] 911045011164 Chromate transporter; Region: Chromate_transp; pfam02417 911045011165 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 911045011166 Chromate transporter; Region: Chromate_transp; pfam02417 911045011167 Cupin domain; Region: Cupin_2; cl09118 911045011168 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045011169 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045011170 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 911045011171 putative catalytic residues [active] 911045011172 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 911045011173 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 911045011174 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045011175 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045011176 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 911045011177 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 911045011178 dimerization interface [polypeptide binding]; other site 911045011179 ATP binding site [chemical binding]; other site 911045011180 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 911045011181 dimerization interface [polypeptide binding]; other site 911045011182 ATP binding site [chemical binding]; other site 911045011183 BolA-like protein; Region: BolA; cl00386 911045011184 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 911045011185 putative GSH binding site [chemical binding]; other site 911045011186 catalytic residues [active] 911045011187 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 911045011188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045011189 motif II; other site 911045011190 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 911045011191 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 911045011192 Ligand Binding Site [chemical binding]; other site 911045011193 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 911045011194 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 911045011195 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045011196 RNA binding surface [nucleotide binding]; other site 911045011197 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 911045011198 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 911045011199 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 911045011200 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 911045011201 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 911045011202 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 911045011203 Protein of unknown function (DUF2585); Region: DUF2585; cl07906 911045011204 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 911045011205 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 911045011206 dimer interface [polypeptide binding]; other site 911045011207 active site 911045011208 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 911045011209 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 911045011210 putative active site [active] 911045011211 catalytic site [active] 911045011212 putative metal binding site [ion binding]; other site 911045011213 Ion transport protein; Region: Ion_trans; pfam00520 911045011214 Ion channel; Region: Ion_trans_2; cl11596 911045011215 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045011216 ligand binding site [chemical binding]; other site 911045011217 flexible hinge region; other site 911045011218 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 911045011219 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 911045011220 motif 1; other site 911045011221 active site 911045011222 motif 2; other site 911045011223 motif 3; other site 911045011224 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 911045011225 recombinase A; Provisional; Region: recA; PRK09354 911045011226 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 911045011227 hexamer interface [polypeptide binding]; other site 911045011228 Walker A motif; other site 911045011229 ATP binding site [chemical binding]; other site 911045011230 Walker B motif; other site 911045011231 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 911045011232 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045011233 substrate binding site [chemical binding]; other site 911045011234 ATP binding site [chemical binding]; other site 911045011235 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 911045011236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 911045011237 PAS domain; Region: PAS_9; pfam13426 911045011238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 911045011239 putative active site [active] 911045011240 heme pocket [chemical binding]; other site 911045011241 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 911045011242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045011243 dimer interface [polypeptide binding]; other site 911045011244 phosphorylation site [posttranslational modification] 911045011245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045011246 ATP binding site [chemical binding]; other site 911045011247 Mg2+ binding site [ion binding]; other site 911045011248 G-X-G motif; other site 911045011249 Response regulator receiver domain; Region: Response_reg; pfam00072 911045011250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045011251 active site 911045011252 phosphorylation site [posttranslational modification] 911045011253 intermolecular recognition site; other site 911045011254 dimerization interface [polypeptide binding]; other site 911045011255 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 911045011256 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 911045011257 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 911045011258 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 911045011259 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 911045011260 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 911045011261 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 911045011262 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 911045011263 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 911045011264 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 911045011265 FliP family; Region: FliP; cl00593 911045011266 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 911045011267 MgtE intracellular N domain; Region: MgtE_N; cl15244 911045011268 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 911045011269 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 911045011270 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 911045011271 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 911045011272 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 911045011273 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 911045011274 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 911045011275 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 911045011276 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 911045011277 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 911045011278 SAF domain; Region: SAF; cl00555 911045011279 Flagellar L-ring protein; Region: FlgH; cl00905 911045011280 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 911045011281 Class II flagellar assembly regulator; Region: FliX; cl11677 911045011282 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 911045011283 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 911045011284 Rod binding protein; Region: Rod-binding; cl01626 911045011285 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 911045011286 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 911045011287 flagellin; Provisional; Region: PRK14708 911045011288 Flagellar protein FlbT; Region: FlbT; cl11455 911045011289 Flagellar protein FlaF; Region: FlaF; cl11454 911045011290 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 911045011291 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 911045011292 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 911045011293 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 911045011294 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 911045011295 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 911045011296 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 911045011297 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 911045011298 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 911045011299 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 911045011300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045011301 Walker A motif; other site 911045011302 ATP binding site [chemical binding]; other site 911045011303 Walker B motif; other site 911045011304 arginine finger; other site 911045011305 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045011306 catalytic core [active] 911045011307 YcjX-like family, DUF463; Region: DUF463; cl01193 911045011308 Domain of unknown function (DUF697); Region: DUF697; cl12064 911045011309 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 911045011310 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 911045011311 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 911045011312 Helix-turn-helix domain; Region: HTH_18; pfam12833 911045011313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045011314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045011315 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045011316 putative substrate translocation pore; other site 911045011317 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 911045011318 Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513 911045011319 gp58-like protein; Region: Gp58; pfam07902 911045011320 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 911045011321 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 911045011322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045011323 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 911045011324 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045011325 Protein of unknown function (DUF330); Region: DUF330; cl01135 911045011326 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 911045011327 mce related protein; Region: MCE; pfam02470 911045011328 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 911045011329 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 911045011330 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 911045011331 Walker A/P-loop; other site 911045011332 ATP binding site [chemical binding]; other site 911045011333 Q-loop/lid; other site 911045011334 ABC transporter signature motif; other site 911045011335 Walker B; other site 911045011336 D-loop; other site 911045011337 H-loop/switch region; other site 911045011338 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 911045011339 Permease; Region: Permease; cl00510 911045011340 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 911045011341 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 911045011342 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 911045011343 active site 911045011344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045011345 sugar efflux transporter; Region: 2A0120; TIGR00899 911045011346 putative substrate translocation pore; other site 911045011347 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 911045011348 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 911045011349 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 911045011350 tetramer interface [polypeptide binding]; other site 911045011351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045011352 catalytic residue [active] 911045011353 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 911045011354 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045011355 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 911045011356 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045011357 putative active site [active] 911045011358 putative metal binding site [ion binding]; other site 911045011359 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 911045011360 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 911045011361 putative NAD(P) binding site [chemical binding]; other site 911045011362 putative active site [active] 911045011363 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045011364 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045011365 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045011366 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 911045011367 dimer interface [polypeptide binding]; other site 911045011368 substrate binding site [chemical binding]; other site 911045011369 ATP binding site [chemical binding]; other site 911045011370 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 911045011371 substrate binding site [chemical binding]; other site 911045011372 multimerization interface [polypeptide binding]; other site 911045011373 ATP binding site [chemical binding]; other site 911045011374 Helix-turn-helix domains; Region: HTH; cl00088 911045011375 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 911045011376 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 911045011377 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045011378 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045011379 EamA-like transporter family; Region: EamA; cl01037 911045011380 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 911045011381 AMP-binding enzyme; Region: AMP-binding; cl15778 911045011382 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045011383 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 911045011384 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045011385 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 911045011386 active site 911045011387 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045011388 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 911045011389 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 911045011390 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 911045011391 Dehydratase family; Region: ILVD_EDD; cl00340 911045011392 6-phosphogluconate dehydratase; Region: edd; TIGR01196 911045011393 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 911045011394 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 911045011395 active site 911045011396 intersubunit interface [polypeptide binding]; other site 911045011397 catalytic residue [active] 911045011398 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 911045011399 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 911045011400 active site 911045011401 dimer interface [polypeptide binding]; other site 911045011402 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 911045011403 dimer interface [polypeptide binding]; other site 911045011404 active site 911045011405 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 911045011406 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 911045011407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045011408 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 911045011409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045011410 putative DNA binding site [nucleotide binding]; other site 911045011411 putative Zn2+ binding site [ion binding]; other site 911045011412 Helix-turn-helix domains; Region: HTH; cl00088 911045011413 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 911045011414 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 911045011415 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 911045011416 active site residue [active] 911045011417 Killing trait; Region: RebB; pfam11747 911045011418 Killing trait; Region: RebB; pfam11747 911045011419 Killing trait; Region: RebB; pfam11747 911045011420 Killing trait; Region: RebB; pfam11747 911045011421 Killing trait; Region: RebB; pfam11747 911045011422 RNA polymerase sigma factor; Provisional; Region: PRK12546 911045011423 Sin3 binding region of histone deacetylase complex subunit SAP30; Region: SAP30_Sin3_bdg; pfam13867 911045011424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 911045011425 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045011426 AAA domain; Region: AAA_28; pfam13521 911045011427 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045011428 DNA binding site [nucleotide binding] 911045011429 Int/Topo IB signature motif; other site 911045011430 active site 911045011431 BCCT family transporter; Region: BCCT; cl00569 911045011432 Cupin domain; Region: Cupin_2; cl09118 911045011433 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045011434 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 911045011435 NAD(P) binding site [chemical binding]; other site 911045011436 catalytic residues [active] 911045011437 catalytic residues [active] 911045011438 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 911045011439 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 911045011440 [2Fe-2S] cluster binding site [ion binding]; other site 911045011441 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 911045011442 alpha subunit interface [polypeptide binding]; other site 911045011443 active site 911045011444 substrate binding site [chemical binding]; other site 911045011445 Fe binding site [ion binding]; other site 911045011446 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045011447 Helix-turn-helix domains; Region: HTH; cl00088 911045011448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045011449 dimerization interface [polypeptide binding]; other site 911045011450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045011451 FAD dependent oxidoreductase; Region: DAO; pfam01266 911045011452 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 911045011453 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 911045011454 FMN-binding pocket [chemical binding]; other site 911045011455 flavin binding motif; other site 911045011456 phosphate binding motif [ion binding]; other site 911045011457 beta-alpha-beta structure motif; other site 911045011458 NAD binding pocket [chemical binding]; other site 911045011459 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045011460 catalytic loop [active] 911045011461 iron binding site [ion binding]; other site 911045011462 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 911045011463 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 911045011464 active site 911045011465 catalytic triad [active] 911045011466 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 911045011467 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 911045011468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045011469 Walker A motif; other site 911045011470 ATP binding site [chemical binding]; other site 911045011471 Walker B motif; other site 911045011472 arginine finger; other site 911045011473 DDE domain; Region: DDE_Tnp_IS240; pfam13610 911045011474 Integrase core domain; Region: rve; cl01316 911045011475 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 911045011476 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 911045011477 PspA/IM30 family; Region: PspA_IM30; pfam04012 911045011478 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 911045011479 Ion channel; Region: Ion_trans_2; cl11596 911045011480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045011481 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 911045011482 Predicted membrane protein [Function unknown]; Region: COG3766 911045011483 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 911045011484 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 911045011485 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 911045011486 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 911045011487 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045011488 PYR/PP interface [polypeptide binding]; other site 911045011489 dimer interface [polypeptide binding]; other site 911045011490 TPP binding site [chemical binding]; other site 911045011491 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 911045011492 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 911045011493 TPP-binding site [chemical binding]; other site 911045011494 dimer interface [polypeptide binding]; other site 911045011495 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 911045011496 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 911045011497 putative valine binding site [chemical binding]; other site 911045011498 dimer interface [polypeptide binding]; other site 911045011499 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 911045011500 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cl00541 911045011501 hydrophilic channel; other site 911045011502 active site 911045011503 catalytic residues [active] 911045011504 active site lid [active] 911045011505 dimerization interface [polypeptide binding]; other site 911045011506 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 911045011507 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 911045011508 Omptin family; Region: Omptin; cl01886 911045011509 intracellular protease, PfpI family; Region: PfpI; TIGR01382 911045011510 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 911045011511 conserved cys residue [active] 911045011512 Ribbon-helix-helix domain; Region: RHH_4; cl01775 911045011513 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 911045011514 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 911045011515 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045011516 putative inner membrane protein; Provisional; Region: PRK11099 911045011517 Sulphur transport; Region: Sulf_transp; cl01018 911045011518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045011519 ketol-acid reductoisomerase; Provisional; Region: PRK05479 911045011520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045011521 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 911045011522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045011523 sugar efflux transporter; Region: 2A0120; TIGR00899 911045011524 putative substrate translocation pore; other site 911045011525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045011526 sugar efflux transporter; Region: 2A0120; TIGR00899 911045011527 putative substrate translocation pore; other site 911045011528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045011529 Coenzyme A binding pocket [chemical binding]; other site 911045011530 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045011531 Sel1 repeat; Region: Sel1; cl02723 911045011532 Sel1 repeat; Region: Sel1; cl02723 911045011533 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045011534 Sel1 repeat; Region: Sel1; cl02723 911045011535 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045011536 Sel1 repeat; Region: Sel1; cl02723 911045011537 Sel1 repeat; Region: Sel1; cl02723 911045011538 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045011539 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045011540 Sel1 repeat; Region: Sel1; cl02723 911045011541 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 911045011542 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045011543 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045011544 Sel1 repeat; Region: Sel1; cl02723 911045011545 Sel1 repeat; Region: Sel1; cl02723 911045011546 Sel1 repeat; Region: Sel1; cl02723 911045011547 Sel1 repeat; Region: Sel1; cl02723 911045011548 Sel1 repeat; Region: Sel1; cl02723 911045011549 Sel1 repeat; Region: Sel1; cl02723 911045011550 Sel1 repeat; Region: Sel1; cl02723 911045011551 Sel1 repeat; Region: Sel1; cl02723 911045011552 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045011553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045011554 Coenzyme A binding pocket [chemical binding]; other site 911045011555 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045011556 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 911045011557 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 911045011558 2-isopropylmalate synthase; Validated; Region: PRK00915 911045011559 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 911045011560 active site 911045011561 catalytic residues [active] 911045011562 metal binding site [ion binding]; metal-binding site 911045011563 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 911045011564 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045011565 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045011566 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045011567 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 911045011568 phosphoserine phosphatase SerB; Region: serB; TIGR00338 911045011569 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045011570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045011571 motif II; other site 911045011572 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 911045011573 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 911045011574 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 911045011575 protein binding site [polypeptide binding]; other site 911045011576 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 911045011577 protein binding site [polypeptide binding]; other site 911045011578 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275 911045011579 HflC protein; Region: hflC; TIGR01932 911045011580 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 911045011581 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 911045011582 HflK protein; Region: hflK; TIGR01933 911045011583 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045011584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045011585 Coenzyme A binding pocket [chemical binding]; other site 911045011586 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 911045011587 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 911045011588 folate binding site [chemical binding]; other site 911045011589 NADP+ binding site [chemical binding]; other site 911045011590 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045011591 catalytic core [active] 911045011592 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045011593 active site 911045011594 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 911045011595 dimerization interface [polypeptide binding]; other site 911045011596 active site 911045011597 Stringent starvation protein B; Region: SspB; cl01120 911045011598 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 911045011599 Ribbon-helix-helix domain; Region: RHH_4; cl01775 911045011600 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 911045011601 AsmA-like C-terminal region; Region: AsmA_2; cl15864 911045011602 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 911045011603 FAD binding domain; Region: FAD_binding_4; pfam01565 911045011604 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 911045011605 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 911045011606 Cl- selectivity filter; other site 911045011607 Cl- binding residues [ion binding]; other site 911045011608 pore gating glutamate residue; other site 911045011609 dimer interface [polypeptide binding]; other site 911045011610 Cupin domain; Region: Cupin_2; cl09118 911045011611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045011612 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045011613 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045011614 AzlC protein; Region: AzlC; cl00570 911045011615 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 911045011616 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045011617 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 911045011618 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045011619 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 911045011620 active site 911045011621 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 911045011622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045011623 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 911045011624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045011625 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 911045011626 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045011627 Family description; Region: UvrD_C_2; cl15862 911045011628 Domain of unknown function (DUF305); Region: DUF305; cl15795 911045011629 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 911045011630 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 911045011631 nucleotide binding pocket [chemical binding]; other site 911045011632 K-X-D-G motif; other site 911045011633 catalytic site [active] 911045011634 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 911045011635 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 911045011636 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 911045011637 Dimer interface [polypeptide binding]; other site 911045011638 BRCT sequence motif; other site 911045011639 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 911045011640 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045011641 dimerization interface [polypeptide binding]; other site 911045011642 putative DNA binding site [nucleotide binding]; other site 911045011643 putative Zn2+ binding site [ion binding]; other site 911045011644 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 911045011645 putative hydrophobic ligand binding site [chemical binding]; other site 911045011646 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 911045011647 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045011648 Walker A/P-loop; other site 911045011649 ATP binding site [chemical binding]; other site 911045011650 Q-loop/lid; other site 911045011651 ABC transporter signature motif; other site 911045011652 Walker B; other site 911045011653 D-loop; other site 911045011654 H-loop/switch region; other site 911045011655 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 911045011656 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: APH; cd05150 911045011657 active site 911045011658 ATP binding site [chemical binding]; other site 911045011659 antibiotic binding site [chemical binding]; other site 911045011660 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 911045011661 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 911045011662 Walker A/P-loop; other site 911045011663 ATP binding site [chemical binding]; other site 911045011664 Q-loop/lid; other site 911045011665 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 911045011666 Q-loop/lid; other site 911045011667 ABC transporter signature motif; other site 911045011668 Walker B; other site 911045011669 D-loop; other site 911045011670 H-loop/switch region; other site 911045011671 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 911045011672 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 911045011673 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 911045011674 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 911045011675 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 911045011676 nucleotide binding site [chemical binding]; other site 911045011677 SulA interaction site; other site 911045011678 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 911045011679 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 911045011680 Cell division protein FtsA; Region: FtsA; cl11496 911045011681 Cell division protein FtsA; Region: FtsA; cl11496 911045011682 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 911045011683 Cell division protein FtsQ; Region: FtsQ; pfam03799 911045011684 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 911045011685 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 911045011686 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045011687 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 911045011688 FAD binding domain; Region: FAD_binding_4; pfam01565 911045011689 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 911045011690 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 911045011691 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 911045011692 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 911045011693 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 911045011694 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 911045011695 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 911045011696 active site 911045011697 homodimer interface [polypeptide binding]; other site 911045011698 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 911045011699 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 911045011700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045011701 NAD(P) binding pocket [chemical binding]; other site 911045011702 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 911045011703 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 911045011704 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 911045011705 Mg++ binding site [ion binding]; other site 911045011706 putative catalytic motif [active] 911045011707 putative substrate binding site [chemical binding]; other site 911045011708 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 911045011709 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 911045011710 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 911045011711 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 911045011712 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 911045011713 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 911045011714 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 911045011715 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 911045011716 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 911045011717 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 911045011718 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045011719 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 911045011720 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 911045011721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045011722 cell division protein MraZ; Reviewed; Region: PRK00326 911045011723 MraZ protein; Region: MraZ; pfam02381 911045011724 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 911045011725 DNA interaction; other site 911045011726 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 911045011727 Metal-binding active site; metal-binding site 911045011728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045011729 putative substrate translocation pore; other site 911045011730 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 911045011731 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 911045011732 DNA binding residues [nucleotide binding] 911045011733 putative dimer interface [polypeptide binding]; other site 911045011734 putative metal binding residues [ion binding]; other site 911045011735 peptidase T; Region: peptidase-T; TIGR01882 911045011736 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 911045011737 metal binding site [ion binding]; metal-binding site 911045011738 dimer interface [polypeptide binding]; other site 911045011739 LysE type translocator; Region: LysE; cl00565 911045011740 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 911045011741 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 911045011742 classical (c) SDRs; Region: SDR_c; cd05233 911045011743 NAD(P) binding site [chemical binding]; other site 911045011744 active site 911045011745 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 911045011746 putative hydrophobic ligand binding site [chemical binding]; other site 911045011747 protein interface [polypeptide binding]; other site 911045011748 gate; other site 911045011749 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 911045011750 Prostaglandin dehydrogenases; Region: PGDH; cd05288 911045011751 NAD(P) binding site [chemical binding]; other site 911045011752 substrate binding site [chemical binding]; other site 911045011753 dimer interface [polypeptide binding]; other site 911045011754 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 911045011755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045011756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045011757 homodimer interface [polypeptide binding]; other site 911045011758 catalytic residue [active] 911045011759 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 911045011760 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 911045011761 N-acetyl-D-glucosamine binding site [chemical binding]; other site 911045011762 catalytic residue [active] 911045011763 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 911045011764 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 911045011765 amidase catalytic site [active] 911045011766 Zn binding residues [ion binding]; other site 911045011767 substrate binding site [chemical binding]; other site 911045011768 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 911045011769 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 911045011770 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 911045011771 putative metal binding site [ion binding]; other site 911045011772 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 911045011773 HSP70 interaction site [polypeptide binding]; other site 911045011774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045011775 metal binding site [ion binding]; metal-binding site 911045011776 active site 911045011777 I-site; other site 911045011778 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045011779 5-oxoprolinase; Region: PLN02666 911045011780 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 911045011781 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 911045011782 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 911045011783 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 911045011784 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045011785 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045011786 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045011787 active site 911045011788 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045011789 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 911045011790 putative N-terminal domain interface [polypeptide binding]; other site 911045011791 putative dimer interface [polypeptide binding]; other site 911045011792 putative substrate binding pocket (H-site) [chemical binding]; other site 911045011793 Methyltransferase domain; Region: Methyltransf_31; pfam13847 911045011794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045011795 S-adenosylmethionine binding site [chemical binding]; other site 911045011796 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 911045011797 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 911045011798 BA14K-like protein; Region: BA14K; pfam07886 911045011799 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 911045011800 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045011801 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 911045011802 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 911045011803 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 911045011804 substrate binding pocket [chemical binding]; other site 911045011805 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 911045011806 B12 binding site [chemical binding]; other site 911045011807 cobalt ligand [ion binding]; other site 911045011808 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 911045011809 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 911045011810 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 911045011811 FAD binding site [chemical binding]; other site 911045011812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045011813 dimerization interface [polypeptide binding]; other site 911045011814 putative DNA binding site [nucleotide binding]; other site 911045011815 putative Zn2+ binding site [ion binding]; other site 911045011816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045011817 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 911045011818 Mechanosensitive ion channel; Region: MS_channel; pfam00924 911045011819 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; cl15419 911045011820 Helix-turn-helix domains; Region: HTH; cl00088 911045011821 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 911045011822 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 911045011823 dimerization interface [polypeptide binding]; other site 911045011824 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045011825 DNA binding residues [nucleotide binding] 911045011826 dimerization interface [polypeptide binding]; other site 911045011827 Predicted transcriptional regulator [Transcription]; Region: COG2345 911045011828 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045011829 metal binding site [ion binding]; metal-binding site 911045011830 active site 911045011831 I-site; other site 911045011832 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045011833 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 911045011834 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 911045011835 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045011836 Walker A/P-loop; other site 911045011837 ATP binding site [chemical binding]; other site 911045011838 Q-loop/lid; other site 911045011839 ABC transporter signature motif; other site 911045011840 Walker B; other site 911045011841 D-loop; other site 911045011842 H-loop/switch region; other site 911045011843 ABC transporter; Region: ABC_tran_2; pfam12848 911045011844 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 911045011845 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 911045011846 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 911045011847 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045011848 PAS domain; Region: PAS_9; pfam13426 911045011849 putative active site [active] 911045011850 heme pocket [chemical binding]; other site 911045011851 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045011852 metal binding site [ion binding]; metal-binding site 911045011853 active site 911045011854 I-site; other site 911045011855 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045011856 exonuclease subunit SbcC; Provisional; Region: PRK10246 911045011857 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045011858 Walker A/P-loop; other site 911045011859 ATP binding site [chemical binding]; other site 911045011860 Q-loop/lid; other site 911045011861 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 911045011862 exonuclease subunit SbcC; Provisional; Region: PRK10246 911045011863 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045011864 ABC transporter signature motif; other site 911045011865 Walker B; other site 911045011866 D-loop; other site 911045011867 H-loop/switch region; other site 911045011868 exonuclease subunit SbcD; Provisional; Region: PRK10966 911045011869 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 911045011870 active site 911045011871 metal binding site [ion binding]; metal-binding site 911045011872 DNA binding site [nucleotide binding] 911045011873 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 911045011874 Cupin domain; Region: Cupin_2; cl09118 911045011875 Pirin-related protein [General function prediction only]; Region: COG1741 911045011876 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045011877 putative DNA binding site [nucleotide binding]; other site 911045011878 putative Zn2+ binding site [ion binding]; other site 911045011879 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 911045011880 ArsC family; Region: ArsC; pfam03960 911045011881 catalytic residues [active] 911045011882 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045011883 Predicted acetyltransferase [General function prediction only]; Region: COG3153 911045011884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045011885 Coenzyme A binding pocket [chemical binding]; other site 911045011886 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 911045011887 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 911045011888 catalytic site [active] 911045011889 metal binding site [ion binding]; metal-binding site 911045011890 TolB amino-terminal domain; Region: TolB_N; cl00639 911045011891 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 911045011892 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 911045011893 Domain of unknown function DUF20; Region: UPF0118; pfam01594 911045011894 Protein of unknown function (DUF541); Region: SIMPL; cl01077 911045011895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045011896 putative substrate translocation pore; other site 911045011897 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 911045011898 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045011899 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045011900 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045011901 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045011902 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045011903 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045011904 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045011905 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045011906 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045011907 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 911045011908 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 911045011909 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 911045011910 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 911045011911 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045011912 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 911045011913 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045011914 DNA binding residues [nucleotide binding] 911045011915 CHC2 zinc finger; Region: zf-CHC2; cl15369 911045011916 DNA primase; Validated; Region: dnaG; PRK05667 911045011917 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 911045011918 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 911045011919 active site 911045011920 metal binding site [ion binding]; metal-binding site 911045011921 interdomain interaction site; other site 911045011922 GatB domain; Region: GatB_Yqey; cl11497 911045011923 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 911045011924 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 911045011925 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 911045011926 catalytic site [active] 911045011927 subunit interface [polypeptide binding]; other site 911045011928 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045011929 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 911045011930 DNA binding residues [nucleotide binding] 911045011931 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 911045011932 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 911045011933 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045011934 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045011935 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 911045011936 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045011937 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045011938 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 911045011939 IMP binding site; other site 911045011940 dimer interface [polypeptide binding]; other site 911045011941 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 911045011942 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 911045011943 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 911045011944 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 911045011945 heme-binding site [chemical binding]; other site 911045011946 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045011947 dimer interface [polypeptide binding]; other site 911045011948 putative CheW interface [polypeptide binding]; other site 911045011949 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045011950 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045011951 dimerization interface [polypeptide binding]; other site 911045011952 putative DNA binding site [nucleotide binding]; other site 911045011953 putative Zn2+ binding site [ion binding]; other site 911045011954 Helix-turn-helix domains; Region: HTH; cl00088 911045011955 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 911045011956 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 911045011957 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 911045011958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 911045011959 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045011960 Helix-turn-helix domains; Region: HTH; cl00088 911045011961 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045011962 putative effector binding pocket; other site 911045011963 dimerization interface [polypeptide binding]; other site 911045011964 TMAO/DMSO reductase; Reviewed; Region: PRK05363 911045011965 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 911045011966 Moco binding site; other site 911045011967 metal coordination site [ion binding]; other site 911045011968 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 911045011969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045011970 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 911045011971 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045011972 active site 911045011973 metal binding site [ion binding]; metal-binding site 911045011974 hexamer interface [polypeptide binding]; other site 911045011975 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 911045011976 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 911045011977 elongation factor G; Reviewed; Region: PRK12740 911045011978 G1 box; other site 911045011979 putative GEF interaction site [polypeptide binding]; other site 911045011980 GTP/Mg2+ binding site [chemical binding]; other site 911045011981 Switch I region; other site 911045011982 G2 box; other site 911045011983 G3 box; other site 911045011984 Switch II region; other site 911045011985 G4 box; other site 911045011986 G5 box; other site 911045011987 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 911045011988 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 911045011989 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 911045011990 Protein of unknown function (DUF992); Region: DUF992; pfam06186 911045011991 aspartate aminotransferase; Provisional; Region: PRK05764 911045011992 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045011993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045011994 homodimer interface [polypeptide binding]; other site 911045011995 catalytic residue [active] 911045011996 GtrA-like protein; Region: GtrA; cl00971 911045011997 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 911045011998 EamA-like transporter family; Region: EamA; cl01037 911045011999 EamA-like transporter family; Region: EamA; cl01037 911045012000 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045012001 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 911045012002 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045012003 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 911045012004 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045012005 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045012006 excinuclease ABC subunit B; Provisional; Region: PRK05298 911045012007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045012008 ATP binding site [chemical binding]; other site 911045012009 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045012010 nucleotide binding region [chemical binding]; other site 911045012011 ATP-binding site [chemical binding]; other site 911045012012 Ultra-violet resistance protein B; Region: UvrB; pfam12344 911045012013 UvrB/uvrC motif; Region: UVR; pfam02151 911045012014 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045012015 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045012016 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 911045012017 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 911045012018 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 911045012019 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045012020 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 911045012021 DNA-binding site [nucleotide binding]; DNA binding site 911045012022 RNA-binding motif; other site 911045012023 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 911045012024 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045012025 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045012026 putative glutathione S-transferase; Provisional; Region: PRK10357 911045012027 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 911045012028 dimer interface [polypeptide binding]; other site 911045012029 N-terminal domain interface [polypeptide binding]; other site 911045012030 putative substrate binding pocket (H-site) [chemical binding]; other site 911045012031 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045012032 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045012033 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 911045012034 dimer interface [polypeptide binding]; other site 911045012035 N-terminal domain interface [polypeptide binding]; other site 911045012036 putative substrate binding pocket (H-site) [chemical binding]; other site 911045012037 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045012038 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 911045012039 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 911045012040 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 911045012041 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 911045012042 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 911045012043 GIY-YIG motif/motif A; other site 911045012044 active site 911045012045 catalytic site [active] 911045012046 putative DNA binding site [nucleotide binding]; other site 911045012047 metal binding site [ion binding]; metal-binding site 911045012048 UvrB/uvrC motif; Region: UVR; pfam02151 911045012049 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 911045012050 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045012051 putative catalytic site [active] 911045012052 putative metal binding site [ion binding]; other site 911045012053 putative phosphate binding site [ion binding]; other site 911045012054 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 911045012055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045012056 motif II; other site 911045012057 thymidine kinase; Provisional; Region: PRK04296 911045012058 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045012059 ATP binding site [chemical binding]; other site 911045012060 Walker A motif; other site 911045012061 Walker B motif; other site 911045012062 Transcriptional activator HlyU; Region: HlyU; cl02273 911045012063 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 911045012064 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 911045012065 MoaE interaction surface [polypeptide binding]; other site 911045012066 MoeB interaction surface [polypeptide binding]; other site 911045012067 thiocarboxylated glycine; other site 911045012068 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 911045012069 MoaE homodimer interface [polypeptide binding]; other site 911045012070 MoaD interaction [polypeptide binding]; other site 911045012071 active site residues [active] 911045012072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045012073 putative substrate translocation pore; other site 911045012074 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 911045012075 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 911045012076 homodimer interface [polypeptide binding]; other site 911045012077 substrate-cofactor binding pocket; other site 911045012078 catalytic residue [active] 911045012079 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045012080 Helix-turn-helix domains; Region: HTH; cl00088 911045012081 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 911045012082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012083 active site 911045012084 phosphorylation site [posttranslational modification] 911045012085 intermolecular recognition site; other site 911045012086 dimerization interface [polypeptide binding]; other site 911045012087 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045012088 DNA binding site [nucleotide binding] 911045012089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045012090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045012091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045012092 dimer interface [polypeptide binding]; other site 911045012093 phosphorylation site [posttranslational modification] 911045012094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045012095 ATP binding site [chemical binding]; other site 911045012096 Mg2+ binding site [ion binding]; other site 911045012097 G-X-G motif; other site 911045012098 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 911045012099 dimer interface [polypeptide binding]; other site 911045012100 putative tRNA-binding site [nucleotide binding]; other site 911045012101 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 911045012102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045012103 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 911045012104 Membrane fusogenic activity; Region: BMFP; cl01115 911045012105 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 911045012106 Uncharacterized conserved protein [Function unknown]; Region: COG1565 911045012107 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 911045012108 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 911045012109 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 911045012110 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 911045012111 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045012112 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 911045012113 active site 911045012114 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 911045012115 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 911045012116 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045012117 active site 911045012118 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 911045012119 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 911045012120 5S rRNA interface [nucleotide binding]; other site 911045012121 CTC domain interface [polypeptide binding]; other site 911045012122 L16 interface [polypeptide binding]; other site 911045012123 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 911045012124 putative active site [active] 911045012125 catalytic residue [active] 911045012126 GTP-binding protein YchF; Reviewed; Region: PRK09601 911045012127 YchF GTPase; Region: YchF; cd01900 911045012128 G1 box; other site 911045012129 GTP/Mg2+ binding site [chemical binding]; other site 911045012130 Switch I region; other site 911045012131 G2 box; other site 911045012132 Switch II region; other site 911045012133 G3 box; other site 911045012134 G4 box; other site 911045012135 G5 box; other site 911045012136 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 911045012137 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 911045012138 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045012139 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045012140 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045012141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045012142 Coenzyme A binding pocket [chemical binding]; other site 911045012143 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 911045012144 putative FMN binding site [chemical binding]; other site 911045012145 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 911045012146 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045012147 active site 911045012148 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 911045012149 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 911045012150 Cytochrome c; Region: Cytochrom_C; cl11414 911045012151 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 911045012152 cytochrome b; Provisional; Region: CYTB; MTH00156 911045012153 Qi binding site; other site 911045012154 intrachain domain interface; other site 911045012155 interchain domain interface [polypeptide binding]; other site 911045012156 heme bH binding site [chemical binding]; other site 911045012157 heme bL binding site [chemical binding]; other site 911045012158 Qo binding site; other site 911045012159 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 911045012160 interchain domain interface [polypeptide binding]; other site 911045012161 intrachain domain interface; other site 911045012162 Qi binding site; other site 911045012163 Qo binding site; other site 911045012164 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 911045012165 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 911045012166 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 911045012167 [2Fe-2S] cluster binding site [ion binding]; other site 911045012168 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 911045012169 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045012170 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045012171 Walker A/P-loop; other site 911045012172 ATP binding site [chemical binding]; other site 911045012173 Q-loop/lid; other site 911045012174 ABC transporter signature motif; other site 911045012175 Walker B; other site 911045012176 D-loop; other site 911045012177 H-loop/switch region; other site 911045012178 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 911045012179 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 911045012180 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 911045012181 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 911045012182 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 911045012183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045012184 Helix-turn-helix domains; Region: HTH; cl00088 911045012185 fumarate hydratase; Reviewed; Region: fumC; PRK00485 911045012186 Class II fumarases; Region: Fumarase_classII; cd01362 911045012187 active site 911045012188 tetramer interface [polypeptide binding]; other site 911045012189 Predicted ATPase [General function prediction only]; Region: COG4637 911045012190 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 911045012191 Q-loop/lid; other site 911045012192 ABC transporter signature motif; other site 911045012193 Walker B; other site 911045012194 D-loop; other site 911045012195 H-loop/switch region; other site 911045012196 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 911045012197 Helix-turn-helix domains; Region: HTH; cl00088 911045012198 OsmC-like protein; Region: OsmC; cl00767 911045012199 Tim44-like domain; Region: Tim44; cl09208 911045012200 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 911045012201 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 911045012202 active site 911045012203 NTP binding site [chemical binding]; other site 911045012204 metal binding triad [ion binding]; metal-binding site 911045012205 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 911045012206 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 911045012207 putative active site [active] 911045012208 putative CoA binding site [chemical binding]; other site 911045012209 nudix motif; other site 911045012210 metal binding site [ion binding]; metal-binding site 911045012211 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 911045012212 MoxR-like ATPases [General function prediction only]; Region: COG0714 911045012213 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045012214 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 911045012215 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 911045012216 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 911045012217 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 911045012218 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 911045012219 Predicted acetyltransferase [General function prediction only]; Region: COG3153 911045012220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045012221 Coenzyme A binding pocket [chemical binding]; other site 911045012222 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 911045012223 nudix motif; other site 911045012224 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 911045012225 active site 911045012226 metal binding site [ion binding]; metal-binding site 911045012227 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 911045012228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045012229 Coenzyme A binding pocket [chemical binding]; other site 911045012230 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 911045012231 FHIPEP family; Region: FHIPEP; pfam00771 911045012232 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 911045012233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045012234 Walker A motif; other site 911045012235 ATP binding site [chemical binding]; other site 911045012236 Walker B motif; other site 911045012237 arginine finger; other site 911045012238 Helix-turn-helix domains; Region: HTH; cl00088 911045012239 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 911045012240 flagellar assembly protein H; Validated; Region: fliH; PRK06032 911045012241 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 911045012242 MgtE intracellular N domain; Region: MgtE_N; cl15244 911045012243 FliG C-terminal domain; Region: FliG_C; pfam01706 911045012244 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 911045012245 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 911045012246 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 911045012247 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 911045012248 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 911045012249 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 911045012250 FlgD Ig-like domain; Region: FlgD_ig; cl15790 911045012251 ribonuclease E; Reviewed; Region: rne; PRK10811 911045012252 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 911045012253 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 911045012254 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 911045012255 Ligand Binding Site [chemical binding]; other site 911045012256 Protein of unknown function, DUF399; Region: DUF399; cl01139 911045012257 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 911045012258 Protein export membrane protein; Region: SecD_SecF; cl14618 911045012259 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045012260 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045012261 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 911045012262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045012263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045012264 dimer interface [polypeptide binding]; other site 911045012265 phosphorylation site [posttranslational modification] 911045012266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045012267 ATP binding site [chemical binding]; other site 911045012268 Mg2+ binding site [ion binding]; other site 911045012269 G-X-G motif; other site 911045012270 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045012271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012272 active site 911045012273 phosphorylation site [posttranslational modification] 911045012274 intermolecular recognition site; other site 911045012275 dimerization interface [polypeptide binding]; other site 911045012276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045012277 DNA binding site [nucleotide binding] 911045012278 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045012279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045012280 dimer interface [polypeptide binding]; other site 911045012281 conserved gate region; other site 911045012282 putative PBP binding loops; other site 911045012283 ABC-ATPase subunit interface; other site 911045012284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045012285 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045012286 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045012287 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045012288 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045012289 Walker A/P-loop; other site 911045012290 ATP binding site [chemical binding]; other site 911045012291 Q-loop/lid; other site 911045012292 ABC transporter signature motif; other site 911045012293 Walker B; other site 911045012294 D-loop; other site 911045012295 H-loop/switch region; other site 911045012296 TOBE domain; Region: TOBE_2; cl01440 911045012297 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045012298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045012299 domain linker motif; other site 911045012300 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045012301 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 911045012302 putative active site [active] 911045012303 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 911045012304 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 911045012305 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045012306 Predicted membrane protein [Function unknown]; Region: COG4267 911045012307 TM1410 hypothetical-related protein; Region: DUF297; cl00997 911045012308 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 911045012309 Cupin domain; Region: Cupin_2; cl09118 911045012310 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 911045012311 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045012312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 911045012313 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 911045012314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045012315 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 911045012316 Uncharacterized conserved protein [Function unknown]; Region: COG3496 911045012317 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 911045012318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045012319 S-adenosylmethionine binding site [chemical binding]; other site 911045012320 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045012321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045012322 short chain dehydrogenase; Provisional; Region: PRK06101 911045012323 NAD(P) binding site [chemical binding]; other site 911045012324 active site 911045012325 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 911045012326 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 911045012327 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 911045012328 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 911045012329 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045012330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045012331 dimer interface [polypeptide binding]; other site 911045012332 phosphorylation site [posttranslational modification] 911045012333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045012334 ATP binding site [chemical binding]; other site 911045012335 Mg2+ binding site [ion binding]; other site 911045012336 G-X-G motif; other site 911045012337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012338 active site 911045012339 phosphorylation site [posttranslational modification] 911045012340 intermolecular recognition site; other site 911045012341 dimerization interface [polypeptide binding]; other site 911045012342 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 911045012343 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045012344 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 911045012345 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 911045012346 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 911045012347 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 911045012348 molybdopterin cofactor binding site [chemical binding]; other site 911045012349 substrate binding site [chemical binding]; other site 911045012350 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 911045012351 molybdopterin cofactor binding site; other site 911045012352 enoyl-CoA hydratase; Validated; Region: PRK08788 911045012353 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045012354 substrate binding site [chemical binding]; other site 911045012355 oxyanion hole (OAH) forming residues; other site 911045012356 trimer interface [polypeptide binding]; other site 911045012357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045012358 dimer interface [polypeptide binding]; other site 911045012359 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 911045012360 phosphorylation site [posttranslational modification] 911045012361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045012362 ATP binding site [chemical binding]; other site 911045012363 Mg2+ binding site [ion binding]; other site 911045012364 G-X-G motif; other site 911045012365 Response regulator receiver domain; Region: Response_reg; pfam00072 911045012366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012367 active site 911045012368 phosphorylation site [posttranslational modification] 911045012369 intermolecular recognition site; other site 911045012370 dimerization interface [polypeptide binding]; other site 911045012371 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 911045012372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012373 active site 911045012374 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 911045012375 phosphorylation site [posttranslational modification] 911045012376 intermolecular recognition site; other site 911045012377 dimerization interface [polypeptide binding]; other site 911045012378 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045012379 metal binding site [ion binding]; metal-binding site 911045012380 active site 911045012381 I-site; other site 911045012382 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045012383 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045012384 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045012385 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045012386 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 911045012387 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 911045012388 Walker A/P-loop; other site 911045012389 ATP binding site [chemical binding]; other site 911045012390 Q-loop/lid; other site 911045012391 ABC transporter signature motif; other site 911045012392 Walker B; other site 911045012393 D-loop; other site 911045012394 H-loop/switch region; other site 911045012395 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 911045012396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045012397 NAD(P) binding site [chemical binding]; other site 911045012398 active site 911045012399 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 911045012400 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045012401 N-terminal plug; other site 911045012402 ligand-binding site [chemical binding]; other site 911045012403 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 911045012404 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 911045012405 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 911045012406 4Fe-4S binding domain; Region: Fer4_5; pfam12801 911045012407 4Fe-4S binding domain; Region: Fer4_5; pfam12801 911045012408 4Fe-4S binding domain; Region: Fer4; cl02805 911045012409 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 911045012410 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 911045012411 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 911045012412 [4Fe-4S] binding site [ion binding]; other site 911045012413 molybdopterin cofactor binding site; other site 911045012414 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 911045012415 molybdopterin cofactor binding site; other site 911045012416 NapD protein; Region: NapD; cl01163 911045012417 4Fe-4S binding domain; Region: Fer4; cl02805 911045012418 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 911045012419 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 911045012420 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 911045012421 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 911045012422 metal ion-dependent adhesion site (MIDAS); other site 911045012423 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045012424 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 911045012425 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 911045012426 Low-spin heme binding site [chemical binding]; other site 911045012427 D-pathway; other site 911045012428 K-pathway; other site 911045012429 Binuclear center (active site) [active] 911045012430 Putative proton exit pathway; other site 911045012431 Putative water exit pathway; other site 911045012432 Cytochrome c; Region: Cytochrom_C; cl11414 911045012433 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045012434 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045012435 ligand binding site [chemical binding]; other site 911045012436 flexible hinge region; other site 911045012437 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 911045012438 putative switch regulator; other site 911045012439 non-specific DNA interactions [nucleotide binding]; other site 911045012440 DNA binding site [nucleotide binding] 911045012441 sequence specific DNA binding site [nucleotide binding]; other site 911045012442 putative cAMP binding site [chemical binding]; other site 911045012443 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 911045012444 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 911045012445 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 911045012446 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045012447 Walker A/P-loop; other site 911045012448 ATP binding site [chemical binding]; other site 911045012449 Q-loop/lid; other site 911045012450 ABC transporter signature motif; other site 911045012451 Walker B; other site 911045012452 D-loop; other site 911045012453 H-loop/switch region; other site 911045012454 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 911045012455 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045012456 Walker A/P-loop; other site 911045012457 ATP binding site [chemical binding]; other site 911045012458 Q-loop/lid; other site 911045012459 ABC transporter signature motif; other site 911045012460 Walker B; other site 911045012461 D-loop; other site 911045012462 H-loop/switch region; other site 911045012463 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045012464 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 911045012465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045012466 dimer interface [polypeptide binding]; other site 911045012467 conserved gate region; other site 911045012468 ABC-ATPase subunit interface; other site 911045012469 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045012470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045012471 dimer interface [polypeptide binding]; other site 911045012472 conserved gate region; other site 911045012473 putative PBP binding loops; other site 911045012474 ABC-ATPase subunit interface; other site 911045012475 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 911045012476 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045012477 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045012478 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045012479 Walker A/P-loop; other site 911045012480 ATP binding site [chemical binding]; other site 911045012481 Q-loop/lid; other site 911045012482 ABC transporter signature motif; other site 911045012483 Walker B; other site 911045012484 D-loop; other site 911045012485 H-loop/switch region; other site 911045012486 TOBE domain; Region: TOBE_2; cl01440 911045012487 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 911045012488 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 911045012489 active site 911045012490 catalytic site [active] 911045012491 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 911045012492 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045012493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045012494 dimer interface [polypeptide binding]; other site 911045012495 conserved gate region; other site 911045012496 putative PBP binding loops; other site 911045012497 ABC-ATPase subunit interface; other site 911045012498 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045012499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045012500 dimer interface [polypeptide binding]; other site 911045012501 conserved gate region; other site 911045012502 putative PBP binding loops; other site 911045012503 ABC-ATPase subunit interface; other site 911045012504 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045012505 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045012506 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045012507 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045012508 DNA binding site [nucleotide binding] 911045012509 domain linker motif; other site 911045012510 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 911045012511 ligand binding site [chemical binding]; other site 911045012512 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 911045012513 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 911045012514 Walker A/P-loop; other site 911045012515 ATP binding site [chemical binding]; other site 911045012516 Q-loop/lid; other site 911045012517 ABC transporter signature motif; other site 911045012518 Walker B; other site 911045012519 D-loop; other site 911045012520 H-loop/switch region; other site 911045012521 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 911045012522 FtsX-like permease family; Region: FtsX; cl15850 911045012523 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 911045012524 FtsX-like permease family; Region: FtsX; cl15850 911045012525 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045012526 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 911045012527 E3 interaction surface; other site 911045012528 lipoyl attachment site [posttranslational modification]; other site 911045012529 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045012530 Helix-turn-helix domains; Region: HTH; cl00088 911045012531 WYL domain; Region: WYL; cl14852 911045012532 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045012533 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045012534 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 911045012535 putative N-terminal domain interface [polypeptide binding]; other site 911045012536 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 911045012537 catalytic triad [active] 911045012538 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045012539 NMT1-like family; Region: NMT1_2; cl15260 911045012540 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 911045012541 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045012542 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 911045012543 active site 911045012544 dimerization interface [polypeptide binding]; other site 911045012545 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 911045012546 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 911045012547 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 911045012548 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045012549 Sulphur transport; Region: Sulf_transp; cl01018 911045012550 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 911045012551 Predicted transporter component [General function prediction only]; Region: COG2391 911045012552 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045012553 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045012554 active site 911045012555 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 911045012556 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 911045012557 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 911045012558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 911045012559 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 911045012560 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045012561 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045012562 active site 911045012563 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 911045012564 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045012565 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045012566 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 911045012567 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 911045012568 carboxyltransferase (CT) interaction site; other site 911045012569 biotinylation site [posttranslational modification]; other site 911045012570 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045012571 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045012572 active site 911045012573 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 911045012574 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 911045012575 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 911045012576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045012577 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045012578 NAD(P) binding site [chemical binding]; other site 911045012579 active site 911045012580 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 911045012581 AMP-binding enzyme; Region: AMP-binding; cl15778 911045012582 enoyl-CoA hydratase; Provisional; Region: PRK05995 911045012583 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045012584 substrate binding site [chemical binding]; other site 911045012585 oxyanion hole (OAH) forming residues; other site 911045012586 trimer interface [polypeptide binding]; other site 911045012587 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 911045012588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045012589 Helix-turn-helix domains; Region: HTH; cl00088 911045012590 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 911045012591 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 911045012592 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 911045012593 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 911045012594 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045012595 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 911045012596 putative FMN binding site [chemical binding]; other site 911045012597 putative dimer interface [polypeptide binding]; other site 911045012598 Cupin domain; Region: Cupin_2; cl09118 911045012599 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045012600 active site 911045012601 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 911045012602 Sodium:solute symporter family; Region: SSF; cl00456 911045012603 HNH endonuclease; Region: HNH_5; pfam14279 911045012604 Protein of unknown function (DUF805); Region: DUF805; cl01224 911045012605 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 911045012606 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 911045012607 transmembrane helices; other site 911045012608 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 911045012609 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 911045012610 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 911045012611 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045012612 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045012613 active site 911045012614 metal binding site [ion binding]; metal-binding site 911045012615 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045012616 Helix-turn-helix domains; Region: HTH; cl00088 911045012617 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045012618 putative effector binding pocket; other site 911045012619 dimerization interface [polypeptide binding]; other site 911045012620 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 911045012621 Proline racemase; Region: Pro_racemase; pfam05544 911045012622 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 911045012623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045012624 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 911045012625 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 911045012626 inhibitor site; inhibition site 911045012627 active site 911045012628 dimer interface [polypeptide binding]; other site 911045012629 catalytic residue [active] 911045012630 glycerol kinase; Provisional; Region: glpK; PRK00047 911045012631 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 911045012632 N- and C-terminal domain interface [polypeptide binding]; other site 911045012633 active site 911045012634 MgATP binding site [chemical binding]; other site 911045012635 catalytic site [active] 911045012636 metal binding site [ion binding]; metal-binding site 911045012637 glycerol binding site [chemical binding]; other site 911045012638 homotetramer interface [polypeptide binding]; other site 911045012639 homodimer interface [polypeptide binding]; other site 911045012640 FBP binding site [chemical binding]; other site 911045012641 protein IIAGlc interface [polypeptide binding]; other site 911045012642 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 911045012643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045012644 putative mechanosensitive channel protein; Provisional; Region: PRK11465 911045012645 Mechanosensitive ion channel; Region: MS_channel; pfam00924 911045012646 Paraquat-inducible protein A; Region: PqiA; pfam04403 911045012647 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 911045012648 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045012649 ATP binding site [chemical binding]; other site 911045012650 Walker B motif; other site 911045012651 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045012652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012653 active site 911045012654 phosphorylation site [posttranslational modification] 911045012655 intermolecular recognition site; other site 911045012656 dimerization interface [polypeptide binding]; other site 911045012657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045012658 DNA binding site [nucleotide binding] 911045012659 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 911045012660 homodimer interaction site [polypeptide binding]; other site 911045012661 cofactor binding site; other site 911045012662 EamA-like transporter family; Region: EamA; cl01037 911045012663 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045012664 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 911045012665 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 911045012666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045012667 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 911045012668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012669 active site 911045012670 phosphorylation site [posttranslational modification] 911045012671 intermolecular recognition site; other site 911045012672 dimerization interface [polypeptide binding]; other site 911045012673 CheB methylesterase; Region: CheB_methylest; pfam01339 911045012674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012675 Response regulator receiver domain; Region: Response_reg; pfam00072 911045012676 active site 911045012677 phosphorylation site [posttranslational modification] 911045012678 intermolecular recognition site; other site 911045012679 dimerization interface [polypeptide binding]; other site 911045012680 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 911045012681 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 911045012682 putative binding surface; other site 911045012683 active site 911045012684 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 911045012685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045012686 ATP binding site [chemical binding]; other site 911045012687 Mg2+ binding site [ion binding]; other site 911045012688 G-X-G motif; other site 911045012689 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 911045012690 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 911045012691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012692 Response regulator receiver domain; Region: Response_reg; pfam00072 911045012693 active site 911045012694 phosphorylation site [posttranslational modification] 911045012695 intermolecular recognition site; other site 911045012696 dimerization interface [polypeptide binding]; other site 911045012697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 911045012698 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 911045012699 Protein of unknown function (DUF1134); Region: DUF1134; cl02235 911045012700 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 911045012701 Helix-turn-helix domains; Region: HTH; cl00088 911045012702 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045012703 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 911045012704 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045012705 RNA binding surface [nucleotide binding]; other site 911045012706 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 911045012707 active site 911045012708 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 911045012709 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 911045012710 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045012711 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045012712 DNA binding residues [nucleotide binding] 911045012713 CHASE2 domain; Region: CHASE2; cl01732 911045012714 cyclase homology domain; Region: CHD; cd07302 911045012715 nucleotidyl binding site; other site 911045012716 metal binding site [ion binding]; metal-binding site 911045012717 dimer interface [polypeptide binding]; other site 911045012718 NMT1-like family; Region: NMT1_2; cl15260 911045012719 NMT1/THI5 like; Region: NMT1; pfam09084 911045012720 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 911045012721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045012722 dimer interface [polypeptide binding]; other site 911045012723 conserved gate region; other site 911045012724 putative PBP binding loops; other site 911045012725 ABC-ATPase subunit interface; other site 911045012726 DNA topoisomerase 2; Provisional; Region: PLN03237 911045012727 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 911045012728 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 911045012729 GDP-binding site [chemical binding]; other site 911045012730 ACT binding site; other site 911045012731 IMP binding site; other site 911045012732 EamA-like transporter family; Region: EamA; cl01037 911045012733 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045012734 EamA-like transporter family; Region: EamA; cl01037 911045012735 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 911045012736 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 911045012737 oligomer interface [polypeptide binding]; other site 911045012738 active site 911045012739 metal binding site [ion binding]; metal-binding site 911045012740 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 911045012741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045012742 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 911045012743 putative L-serine binding site [chemical binding]; other site 911045012744 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 911045012745 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045012746 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 911045012747 catalytic residue [active] 911045012748 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045012749 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 911045012750 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 911045012751 active site 911045012752 substrate binding site [chemical binding]; other site 911045012753 metal binding site [ion binding]; metal-binding site 911045012754 FtsH Extracellular; Region: FtsH_ext; pfam06480 911045012755 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 911045012756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045012757 Walker A motif; other site 911045012758 ATP binding site [chemical binding]; other site 911045012759 Walker B motif; other site 911045012760 arginine finger; other site 911045012761 Peptidase family M41; Region: Peptidase_M41; pfam01434 911045012762 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 911045012763 Ligand Binding Site [chemical binding]; other site 911045012764 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 911045012765 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 911045012766 ligand binding site [chemical binding]; other site 911045012767 translocation protein TolB; Provisional; Region: tolB; PRK05137 911045012768 TolB amino-terminal domain; Region: TolB_N; cl00639 911045012769 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 911045012770 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 911045012771 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 911045012772 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 911045012773 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 911045012774 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045012775 active site 911045012776 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 911045012777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045012778 Walker A motif; other site 911045012779 ATP binding site [chemical binding]; other site 911045012780 Walker B motif; other site 911045012781 arginine finger; other site 911045012782 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 911045012783 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 911045012784 RuvA N terminal domain; Region: RuvA_N; pfam01330 911045012785 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 911045012786 active site 911045012787 putative DNA-binding cleft [nucleotide binding]; other site 911045012788 dimer interface [polypeptide binding]; other site 911045012789 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045012790 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045012791 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045012792 Helix-turn-helix domains; Region: HTH; cl00088 911045012793 Transcriptional regulator; Region: Transcrip_reg; cl00361 911045012794 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 911045012795 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045012796 putative active site [active] 911045012797 metal binding site [ion binding]; metal-binding site 911045012798 homodimer binding site [polypeptide binding]; other site 911045012799 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 911045012800 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 911045012801 nucleotide binding site/active site [active] 911045012802 HIT family signature motif; other site 911045012803 catalytic residue [active] 911045012804 Cell division protein ZapA; Region: ZapA; cl01146 911045012805 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 911045012806 transketolase; Reviewed; Region: PRK05899 911045012807 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 911045012808 TPP-binding site [chemical binding]; other site 911045012809 dimer interface [polypeptide binding]; other site 911045012810 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 911045012811 PYR/PP interface [polypeptide binding]; other site 911045012812 dimer interface [polypeptide binding]; other site 911045012813 TPP binding site [chemical binding]; other site 911045012814 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 911045012815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045012816 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 911045012817 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 911045012818 Phosphoglycerate kinase; Region: PGK; pfam00162 911045012819 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 911045012820 substrate binding site [chemical binding]; other site 911045012821 hinge regions; other site 911045012822 ADP binding site [chemical binding]; other site 911045012823 catalytic site [active] 911045012824 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 911045012825 thiamine phosphate binding site [chemical binding]; other site 911045012826 active site 911045012827 pyrophosphate binding site [ion binding]; other site 911045012828 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045012829 Sel1 repeat; Region: Sel1; cl02723 911045012830 Sel1 repeat; Region: Sel1; cl02723 911045012831 elongation factor P; Validated; Region: PRK00529 911045012832 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 911045012833 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 911045012834 RNA binding site [nucleotide binding]; other site 911045012835 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 911045012836 RNA binding site [nucleotide binding]; other site 911045012837 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 911045012838 active site 911045012839 dimerization interface [polypeptide binding]; other site 911045012840 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 911045012841 Helix-turn-helix domains; Region: HTH; cl00088 911045012842 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 911045012843 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045012844 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 911045012845 active site 911045012846 metal binding site [ion binding]; metal-binding site 911045012847 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 911045012848 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045012849 P-loop; other site 911045012850 Magnesium ion binding site [ion binding]; other site 911045012851 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045012852 Magnesium ion binding site [ion binding]; other site 911045012853 hypothetical protein; Validated; Region: PRK09039 911045012854 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 911045012855 ligand binding site [chemical binding]; other site 911045012856 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 911045012857 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 911045012858 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 911045012859 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 911045012860 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 911045012861 NAD(P) binding site [chemical binding]; other site 911045012862 Protein of unknown function (DUF1192); Region: DUF1192; cl11573 911045012863 Protein of unknown function (DUF1465); Region: DUF1465; cl11562 911045012864 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 911045012865 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 911045012866 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045012867 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 911045012868 Walker A/P-loop; other site 911045012869 ATP binding site [chemical binding]; other site 911045012870 Q-loop/lid; other site 911045012871 ABC transporter signature motif; other site 911045012872 Walker B; other site 911045012873 D-loop; other site 911045012874 H-loop/switch region; other site 911045012875 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 911045012876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045012877 NAD(P) binding site [chemical binding]; other site 911045012878 active site 911045012879 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 911045012880 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 911045012881 AMP-binding enzyme; Region: AMP-binding; cl15778 911045012882 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045012883 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045012884 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045012885 acyl-CoA synthetase; Validated; Region: PRK08162 911045012886 AMP-binding enzyme; Region: AMP-binding; cl15778 911045012887 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045012888 Protein of unknown function (DUF465); Region: DUF465; cl01070 911045012889 Protein of unknown function (DUF465); Region: DUF465; cl01070 911045012890 AIR carboxylase; Region: AIRC; cl00310 911045012891 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 911045012892 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 911045012893 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045012894 multidrug efflux protein; Reviewed; Region: PRK01766 911045012895 MatE; Region: MatE; cl10513 911045012896 MatE; Region: MatE; cl10513 911045012897 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 911045012898 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 911045012899 putative dimer interface [polypeptide binding]; other site 911045012900 putative active site [active] 911045012901 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 911045012902 TPR repeat; Region: TPR_11; pfam13414 911045012903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045012904 binding surface 911045012905 TPR motif; other site 911045012906 TPR repeat; Region: TPR_11; pfam13414 911045012907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045012908 binding surface 911045012909 TPR motif; other site 911045012910 TPR repeat; Region: TPR_11; pfam13414 911045012911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045012912 binding surface 911045012913 Tetratricopeptide repeat; Region: TPR_16; pfam13432 911045012914 TPR motif; other site 911045012915 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 911045012916 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 911045012917 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 911045012918 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 911045012919 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045012920 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 911045012921 active site 911045012922 ATP binding site [chemical binding]; other site 911045012923 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 911045012924 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045012925 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045012926 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 911045012927 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045012928 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045012929 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 911045012930 active site 911045012931 metal binding site [ion binding]; metal-binding site 911045012932 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045012933 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045012934 active site 911045012935 metal binding site [ion binding]; metal-binding site 911045012936 adenylosuccinate lyase; Provisional; Region: PRK07492 911045012937 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 911045012938 tetramer interface [polypeptide binding]; other site 911045012939 active site 911045012940 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 911045012941 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045012942 active site 911045012943 metal binding site [ion binding]; metal-binding site 911045012944 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045012945 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 911045012946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045012947 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 911045012948 CoenzymeA binding site [chemical binding]; other site 911045012949 subunit interaction site [polypeptide binding]; other site 911045012950 PHB binding site; other site 911045012951 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 911045012952 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 911045012953 active site 911045012954 Zn binding site [ion binding]; other site 911045012955 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 911045012956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012957 active site 911045012958 phosphorylation site [posttranslational modification] 911045012959 intermolecular recognition site; other site 911045012960 dimerization interface [polypeptide binding]; other site 911045012961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045012962 Walker A motif; other site 911045012963 ATP binding site [chemical binding]; other site 911045012964 Walker B motif; other site 911045012965 arginine finger; other site 911045012966 Helix-turn-helix domains; Region: HTH; cl00088 911045012967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 911045012968 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 911045012969 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 911045012970 Peptidase M15; Region: Peptidase_M15_3; cl01194 911045012971 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480 911045012972 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 911045012973 pyruvate kinase; Provisional; Region: PRK06247 911045012974 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 911045012975 domain interfaces; other site 911045012976 active site 911045012977 short chain dehydrogenase; Provisional; Region: PRK06197 911045012978 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 911045012979 putative NAD(P) binding site [chemical binding]; other site 911045012980 active site 911045012981 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045012982 Helix-turn-helix domains; Region: HTH; cl00088 911045012983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045012984 TPR repeat; Region: TPR_11; pfam13414 911045012985 binding surface 911045012986 TPR motif; other site 911045012987 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 911045012988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012989 Response regulator receiver domain; Region: Response_reg; pfam00072 911045012990 active site 911045012991 phosphorylation site [posttranslational modification] 911045012992 intermolecular recognition site; other site 911045012993 dimerization interface [polypeptide binding]; other site 911045012994 N-formylglutamate amidohydrolase; Region: FGase; cl01522 911045012995 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 911045012996 trimer interface [polypeptide binding]; other site 911045012997 active site 911045012998 substrate binding site [chemical binding]; other site 911045012999 CoA binding site [chemical binding]; other site 911045013000 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 911045013001 active site 911045013002 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 911045013003 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045013004 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 911045013005 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 911045013006 putative dimer interface [polypeptide binding]; other site 911045013007 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 911045013008 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 911045013009 tetramer interface [polypeptide binding]; other site 911045013010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045013011 catalytic residue [active] 911045013012 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045013013 putative catalytic site [active] 911045013014 putative metal binding site [ion binding]; other site 911045013015 putative phosphate binding site [ion binding]; other site 911045013016 DoxX; Region: DoxX; cl00976 911045013017 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 911045013018 Protein of unknown function (DUF692); Region: DUF692; cl01263 911045013019 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 911045013020 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 911045013021 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 911045013022 active site 911045013023 dimer interface [polypeptide binding]; other site 911045013024 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 911045013025 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 911045013026 active site 911045013027 FMN binding site [chemical binding]; other site 911045013028 substrate binding site [chemical binding]; other site 911045013029 3Fe-4S cluster binding site [ion binding]; other site 911045013030 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 911045013031 domain interface; other site 911045013032 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 911045013033 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045013034 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045013035 dimer interface [polypeptide binding]; other site 911045013036 putative CheW interface [polypeptide binding]; other site 911045013037 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 911045013038 active site 911045013039 catalytic triad [active] 911045013040 oxyanion hole [active] 911045013041 Transglycosylase SLT domain; Region: SLT_2; pfam13406 911045013042 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 911045013043 N-acetyl-D-glucosamine binding site [chemical binding]; other site 911045013044 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 911045013045 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 911045013046 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 911045013047 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 911045013048 putative active site [active] 911045013049 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 911045013050 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 911045013051 flagellar motor protein MotP; Reviewed; Region: PRK06926 911045013052 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 911045013053 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 911045013054 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 911045013055 ligand binding site [chemical binding]; other site 911045013056 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 911045013057 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 911045013058 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 911045013059 ferrochelatase; Reviewed; Region: hemH; PRK00035 911045013060 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 911045013061 active site 911045013062 C-terminal domain interface [polypeptide binding]; other site 911045013063 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 911045013064 active site 911045013065 N-terminal domain interface [polypeptide binding]; other site 911045013066 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 911045013067 AMP-binding enzyme; Region: AMP-binding; cl15778 911045013068 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 911045013069 B1 nucleotide binding pocket [chemical binding]; other site 911045013070 B2 nucleotide binding pocket [chemical binding]; other site 911045013071 CAS motifs; other site 911045013072 active site 911045013073 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045013074 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 911045013075 Walker A/P-loop; other site 911045013076 ATP binding site [chemical binding]; other site 911045013077 Q-loop/lid; other site 911045013078 ABC transporter signature motif; other site 911045013079 Walker B; other site 911045013080 D-loop; other site 911045013081 H-loop/switch region; other site 911045013082 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 911045013083 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 911045013084 putative ligand binding site [chemical binding]; other site 911045013085 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045013086 TM-ABC transporter signature motif; other site 911045013087 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045013088 TM-ABC transporter signature motif; other site 911045013089 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 911045013090 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 911045013091 Walker A/P-loop; other site 911045013092 ATP binding site [chemical binding]; other site 911045013093 Q-loop/lid; other site 911045013094 ABC transporter signature motif; other site 911045013095 Walker B; other site 911045013096 D-loop; other site 911045013097 H-loop/switch region; other site 911045013098 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 911045013099 AMP-binding enzyme; Region: AMP-binding; cl15778 911045013100 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045013101 DctM-like transporters; Region: DctM; pfam06808 911045013102 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045013103 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045013104 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 911045013105 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045013106 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 911045013107 High-affinity nickel-transport protein; Region: NicO; cl00964 911045013108 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 911045013109 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 911045013110 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 911045013111 NAD binding site [chemical binding]; other site 911045013112 Phe binding site; other site 911045013113 Helix-turn-helix domains; Region: HTH; cl00088 911045013114 LysR family transcriptional regulator; Provisional; Region: PRK14997 911045013115 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045013116 putative effector binding pocket; other site 911045013117 dimerization interface [polypeptide binding]; other site 911045013118 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 911045013119 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 911045013120 structural tetrad; other site 911045013121 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 911045013122 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 911045013123 P-loop, Walker A motif; other site 911045013124 Base recognition motif; other site 911045013125 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 911045013126 aspartate aminotransferase; Provisional; Region: PRK05764 911045013127 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045013128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045013129 homodimer interface [polypeptide binding]; other site 911045013130 catalytic residue [active] 911045013131 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045013132 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045013133 DNA binding site [nucleotide binding] 911045013134 domain linker motif; other site 911045013135 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045013136 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 911045013137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045013138 Helix-turn-helix domains; Region: HTH; cl00088 911045013139 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 911045013140 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 911045013141 Walker A/P-loop; other site 911045013142 ATP binding site [chemical binding]; other site 911045013143 Q-loop/lid; other site 911045013144 ABC transporter signature motif; other site 911045013145 Walker B; other site 911045013146 D-loop; other site 911045013147 H-loop/switch region; other site 911045013148 Creatinine amidohydrolase; Region: Creatininase; cl00618 911045013149 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 911045013150 B12 binding site [chemical binding]; other site 911045013151 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 911045013152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045013153 FeS/SAM binding site; other site 911045013154 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 911045013155 ArsC family; Region: ArsC; pfam03960 911045013156 putative catalytic residues [active] 911045013157 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 911045013158 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045013159 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045013160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045013161 putative PBP binding loops; other site 911045013162 dimer interface [polypeptide binding]; other site 911045013163 ABC-ATPase subunit interface; other site 911045013164 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 911045013165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045013166 dimer interface [polypeptide binding]; other site 911045013167 conserved gate region; other site 911045013168 ABC-ATPase subunit interface; other site 911045013169 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 911045013170 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045013171 Walker A/P-loop; other site 911045013172 ATP binding site [chemical binding]; other site 911045013173 Q-loop/lid; other site 911045013174 ABC transporter signature motif; other site 911045013175 Walker B; other site 911045013176 D-loop; other site 911045013177 H-loop/switch region; other site 911045013178 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045013179 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045013180 Walker A/P-loop; other site 911045013181 ATP binding site [chemical binding]; other site 911045013182 Q-loop/lid; other site 911045013183 ABC transporter signature motif; other site 911045013184 Walker B; other site 911045013185 D-loop; other site 911045013186 H-loop/switch region; other site 911045013187 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045013188 Uncharacterized conserved protein [Function unknown]; Region: COG4278 911045013189 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 911045013190 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045013191 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045013192 catalytic residue [active] 911045013193 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045013194 putative catalytic site [active] 911045013195 putative metal binding site [ion binding]; other site 911045013196 putative phosphate binding site [ion binding]; other site 911045013197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045013198 S-adenosylmethionine binding site [chemical binding]; other site 911045013199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045013200 Helix-turn-helix domains; Region: HTH; cl00088 911045013201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045013202 dimerization interface [polypeptide binding]; other site 911045013203 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 911045013204 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045013205 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045013206 catalytic residue [active] 911045013207 Helix-turn-helix domains; Region: HTH; cl00088 911045013208 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045013209 dimerization interface [polypeptide binding]; other site 911045013210 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 911045013211 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 911045013212 metal-binding site [ion binding] 911045013213 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 911045013214 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 911045013215 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045013216 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045013217 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 911045013218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045013219 DNA-binding site [nucleotide binding]; DNA binding site 911045013220 FCD domain; Region: FCD; cl11656 911045013221 Uncharacterized conserved protein [Function unknown]; Region: COG3025 911045013222 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 911045013223 putative active site [active] 911045013224 putative metal binding residues [ion binding]; other site 911045013225 signature motif; other site 911045013226 putative triphosphate binding site [ion binding]; other site 911045013227 CHAD domain; Region: CHAD; cl10506 911045013228 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 911045013229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045013230 DNA-binding site [nucleotide binding]; DNA binding site 911045013231 UTRA domain; Region: UTRA; cl01230 911045013232 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 911045013233 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 911045013234 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 911045013235 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 911045013236 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 911045013237 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045013238 Walker A/P-loop; other site 911045013239 ATP binding site [chemical binding]; other site 911045013240 Q-loop/lid; other site 911045013241 ABC transporter signature motif; other site 911045013242 Walker B; other site 911045013243 D-loop; other site 911045013244 H-loop/switch region; other site 911045013245 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045013246 Walker A/P-loop; other site 911045013247 ATP binding site [chemical binding]; other site 911045013248 ABC transporter; Region: ABC_tran; pfam00005 911045013249 Q-loop/lid; other site 911045013250 ABC transporter signature motif; other site 911045013251 Walker B; other site 911045013252 D-loop; other site 911045013253 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 911045013254 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 911045013255 trimer interface [polypeptide binding]; other site 911045013256 active site 911045013257 substrate binding site [chemical binding]; other site 911045013258 CoA binding site [chemical binding]; other site 911045013259 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 911045013260 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 911045013261 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045013262 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 911045013263 active site 911045013264 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045013265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045013266 Helix-turn-helix domains; Region: HTH; cl00088 911045013267 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 911045013268 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 911045013269 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 911045013270 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 911045013271 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045013272 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 911045013273 AsmA family; Region: AsmA; pfam05170 911045013274 AsmA-like C-terminal region; Region: AsmA_2; cl15864 911045013275 AsmA-like C-terminal region; Region: AsmA_2; cl15864 911045013276 tellurium resistance terB-like protein; Region: terB_like; cl11965 911045013277 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 911045013278 metal binding site [ion binding]; metal-binding site 911045013279 putative metal binding site [ion binding]; other site 911045013280 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 911045013281 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 911045013282 catalytic triad [active] 911045013283 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 911045013284 pyruvate carboxylase; Reviewed; Region: PRK12999 911045013285 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045013286 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045013287 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 911045013288 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 911045013289 active site 911045013290 catalytic residues [active] 911045013291 metal binding site [ion binding]; metal-binding site 911045013292 homodimer binding site [polypeptide binding]; other site 911045013293 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 911045013294 carboxyltransferase (CT) interaction site; other site 911045013295 biotinylation site [posttranslational modification]; other site 911045013296 Autoinducer binding domain; Region: Autoind_bind; pfam03472 911045013297 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045013298 DNA binding residues [nucleotide binding] 911045013299 dimerization interface [polypeptide binding]; other site 911045013300 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 911045013301 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045013302 nucleotide binding region [chemical binding]; other site 911045013303 ATP-binding site [chemical binding]; other site 911045013304 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045013305 RNA binding surface [nucleotide binding]; other site 911045013306 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 911045013307 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 911045013308 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 911045013309 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045013310 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045013311 DNA binding residues [nucleotide binding] 911045013312 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 911045013313 Peptidase family M48; Region: Peptidase_M48; cl12018 911045013314 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 911045013315 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 911045013316 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302 911045013317 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 911045013318 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 911045013319 phosphate binding site [ion binding]; other site 911045013320 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045013321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013322 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 911045013323 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 911045013324 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 911045013325 dimerization interface [polypeptide binding]; other site 911045013326 putative active cleft [active] 911045013327 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 911045013328 HemY protein N-terminus; Region: HemY_N; pfam07219 911045013329 hypothetical protein; Provisional; Region: PRK11281 911045013330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 911045013331 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 911045013332 active site 911045013333 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 911045013334 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 911045013335 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 911045013336 domain interfaces; other site 911045013337 active site 911045013338 UGMP family protein; Validated; Region: PRK09604 911045013339 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 911045013340 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045013341 nudix motif; other site 911045013342 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 911045013343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013344 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 911045013345 YCII-related domain; Region: YCII; cl00999 911045013346 EVE domain; Region: EVE; cl00728 911045013347 Predicted methyltransferase [General function prediction only]; Region: COG3897 911045013348 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045013349 DNA binding residues [nucleotide binding] 911045013350 dimerization interface [polypeptide binding]; other site 911045013351 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 911045013352 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 911045013353 metal binding site [ion binding]; metal-binding site 911045013354 putative dimer interface [polypeptide binding]; other site 911045013355 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 911045013356 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 911045013357 tetramer interface [polypeptide binding]; other site 911045013358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045013359 catalytic residue [active] 911045013360 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 911045013361 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 911045013362 Walker A/P-loop; other site 911045013363 ATP binding site [chemical binding]; other site 911045013364 Q-loop/lid; other site 911045013365 ABC transporter signature motif; other site 911045013366 Walker B; other site 911045013367 D-loop; other site 911045013368 H-loop/switch region; other site 911045013369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045013370 dimer interface [polypeptide binding]; other site 911045013371 conserved gate region; other site 911045013372 putative PBP binding loops; other site 911045013373 ABC-ATPase subunit interface; other site 911045013374 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045013375 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045013376 substrate binding pocket [chemical binding]; other site 911045013377 membrane-bound complex binding site; other site 911045013378 hinge residues; other site 911045013379 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 911045013380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045013381 putative acetyltransferase; Provisional; Region: PRK03624 911045013382 Coenzyme A binding pocket [chemical binding]; other site 911045013383 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 911045013384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013385 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 911045013386 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 911045013387 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 911045013388 Predicted acetyltransferase [General function prediction only]; Region: COG3153 911045013389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045013390 Coenzyme A binding pocket [chemical binding]; other site 911045013391 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 911045013392 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 911045013393 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 911045013394 active site 911045013395 tartrate dehydrogenase; Provisional; Region: PRK08194 911045013396 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 911045013397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013398 NAD(P) binding site [chemical binding]; other site 911045013399 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045013400 active site 911045013401 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 911045013402 dimer interface [polypeptide binding]; other site 911045013403 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045013404 active site 911045013405 metal binding site [ion binding]; metal-binding site 911045013406 glutathione binding site [chemical binding]; other site 911045013407 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045013408 MatE; Region: MatE; cl10513 911045013409 MatE; Region: MatE; cl10513 911045013410 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045013411 Helix-turn-helix domains; Region: HTH; cl00088 911045013412 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 911045013413 metal binding site [ion binding]; metal-binding site 911045013414 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 911045013415 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 911045013416 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 911045013417 active site clefts [active] 911045013418 zinc binding site [ion binding]; other site 911045013419 dimer interface [polypeptide binding]; other site 911045013420 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 911045013421 homotrimer interaction site [polypeptide binding]; other site 911045013422 putative active site [active] 911045013423 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 911045013424 putative active site [active] 911045013425 putative catalytic site [active] 911045013426 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 911045013427 putative active site [active] 911045013428 putative catalytic site [active] 911045013429 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045013430 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045013431 dimer interface [polypeptide binding]; other site 911045013432 putative CheW interface [polypeptide binding]; other site 911045013433 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 911045013434 putative protease; Provisional; Region: PRK15452 911045013435 Peptidase family U32; Region: Peptidase_U32; cl03113 911045013436 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045013437 Helix-turn-helix domains; Region: HTH; cl00088 911045013438 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045013439 dimerization interface [polypeptide binding]; other site 911045013440 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045013441 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 911045013442 Citrate synthase; Region: Citrate_synt; pfam00285 911045013443 dimer interface [polypeptide binding]; other site 911045013444 active site 911045013445 oxalacetate/citrate binding site [chemical binding]; other site 911045013446 citrylCoA binding site [chemical binding]; other site 911045013447 coenzyme A binding site [chemical binding]; other site 911045013448 catalytic triad [active] 911045013449 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045013450 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045013451 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045013452 DctM-like transporters; Region: DctM; pfam06808 911045013453 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045013454 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045013455 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045013456 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 911045013457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045013458 active site 911045013459 phosphorylation site [posttranslational modification] 911045013460 intermolecular recognition site; other site 911045013461 dimerization interface [polypeptide binding]; other site 911045013462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045013463 Walker A motif; other site 911045013464 ATP binding site [chemical binding]; other site 911045013465 Walker B motif; other site 911045013466 arginine finger; other site 911045013467 Helix-turn-helix domains; Region: HTH; cl00088 911045013468 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 911045013469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045013470 dimer interface [polypeptide binding]; other site 911045013471 phosphorylation site [posttranslational modification] 911045013472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045013473 ATP binding site [chemical binding]; other site 911045013474 Mg2+ binding site [ion binding]; other site 911045013475 G-X-G motif; other site 911045013476 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 911045013477 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045013478 Walker A/P-loop; other site 911045013479 ATP binding site [chemical binding]; other site 911045013480 Q-loop/lid; other site 911045013481 ABC transporter signature motif; other site 911045013482 Walker B; other site 911045013483 D-loop; other site 911045013484 H-loop/switch region; other site 911045013485 TOBE domain; Region: TOBE_2; cl01440 911045013486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045013487 dimer interface [polypeptide binding]; other site 911045013488 conserved gate region; other site 911045013489 putative PBP binding loops; other site 911045013490 ABC-ATPase subunit interface; other site 911045013491 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045013492 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 911045013493 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 911045013494 putative hydrophobic ligand binding site [chemical binding]; other site 911045013495 protein interface [polypeptide binding]; other site 911045013496 gate; other site 911045013497 Helix-turn-helix domains; Region: HTH; cl00088 911045013498 WYL domain; Region: WYL; cl14852 911045013499 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045013500 dimerization interface [polypeptide binding]; other site 911045013501 putative DNA binding site [nucleotide binding]; other site 911045013502 putative Zn2+ binding site [ion binding]; other site 911045013503 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 911045013504 putative hydrophobic ligand binding site [chemical binding]; other site 911045013505 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 911045013506 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 911045013507 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045013508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045013509 Helix-turn-helix domains; Region: HTH; cl00088 911045013510 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045013511 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045013512 choline dehydrogenase; Validated; Region: PRK02106 911045013513 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 911045013514 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 911045013515 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 911045013516 putative metal binding site [ion binding]; other site 911045013517 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045013518 Helix-turn-helix domains; Region: HTH; cl00088 911045013519 Helix-turn-helix domains; Region: HTH; cl00088 911045013520 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 911045013521 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 911045013522 dimer interface [polypeptide binding]; other site 911045013523 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 911045013524 active site 911045013525 Fe binding site [ion binding]; other site 911045013526 FG-GAP repeat; Region: FG-GAP; cl15299 911045013527 FG-GAP repeat; Region: FG-GAP; cl15299 911045013528 FG-GAP repeat; Region: FG-GAP; cl15299 911045013529 topology modulation protein; Reviewed; Region: PRK08118 911045013530 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045013531 active site 911045013532 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045013533 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045013534 Helix-turn-helix domains; Region: HTH; cl00088 911045013535 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 911045013536 transmembrane helices; other site 911045013537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045013538 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045013539 putative substrate translocation pore; other site 911045013540 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 911045013541 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 911045013542 Cobalt transport protein; Region: CbiQ; cl00463 911045013543 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 911045013544 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 911045013545 Walker A/P-loop; other site 911045013546 ATP binding site [chemical binding]; other site 911045013547 Q-loop/lid; other site 911045013548 ABC transporter signature motif; other site 911045013549 Walker B; other site 911045013550 D-loop; other site 911045013551 H-loop/switch region; other site 911045013552 Protein of unknown function (DUF419); Region: DUF419; cl15265 911045013553 Helix-turn-helix domain; Region: HTH_18; pfam12833 911045013554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045013555 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 911045013556 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 911045013557 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 911045013558 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 911045013559 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 911045013560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045013561 Helix-turn-helix domains; Region: HTH; cl00088 911045013562 enoyl-CoA hydratase; Provisional; Region: PRK12478 911045013563 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045013564 substrate binding site [chemical binding]; other site 911045013565 oxyanion hole (OAH) forming residues; other site 911045013566 trimer interface [polypeptide binding]; other site 911045013567 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045013568 reductive dehalogenase; Region: RDH; TIGR02486 911045013569 reductive dehalogenase; Region: RDH; TIGR02486 911045013570 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 911045013571 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 911045013572 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 911045013573 FMN-binding pocket [chemical binding]; other site 911045013574 flavin binding motif; other site 911045013575 phosphate binding motif [ion binding]; other site 911045013576 beta-alpha-beta structure motif; other site 911045013577 NAD binding pocket [chemical binding]; other site 911045013578 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045013579 catalytic loop [active] 911045013580 iron binding site [ion binding]; other site 911045013581 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045013582 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045013583 DNA binding residues [nucleotide binding] 911045013584 dimerization interface [polypeptide binding]; other site 911045013585 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045013586 DNA binding residues [nucleotide binding] 911045013587 dimerization interface [polypeptide binding]; other site 911045013588 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045013589 DNA binding residues [nucleotide binding] 911045013590 dimerization interface [polypeptide binding]; other site 911045013591 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 911045013592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045013593 dimer interface [polypeptide binding]; other site 911045013594 phosphorylation site [posttranslational modification] 911045013595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 911045013596 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045013597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045013598 active site 911045013599 phosphorylation site [posttranslational modification] 911045013600 intermolecular recognition site; other site 911045013601 dimerization interface [polypeptide binding]; other site 911045013602 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045013603 DNA binding site [nucleotide binding] 911045013604 OsmC-like protein; Region: OsmC; cl00767 911045013605 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 911045013606 Prostaglandin dehydrogenases; Region: PGDH; cd05288 911045013607 NAD(P) binding site [chemical binding]; other site 911045013608 substrate binding site [chemical binding]; other site 911045013609 dimer interface [polypeptide binding]; other site 911045013610 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 911045013611 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 911045013612 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045013613 Helix-turn-helix domains; Region: HTH; cl00088 911045013614 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 911045013615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045013616 Helix-turn-helix domains; Region: HTH; cl00088 911045013617 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 911045013618 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 911045013619 isovaleryl-CoA dehydrogenase; Region: PLN02519 911045013620 substrate binding site [chemical binding]; other site 911045013621 FAD binding site [chemical binding]; other site 911045013622 catalytic base [active] 911045013623 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 911045013624 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 911045013625 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 911045013626 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045013627 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045013628 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 911045013629 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 911045013630 carboxyltransferase (CT) interaction site; other site 911045013631 biotinylation site [posttranslational modification]; other site 911045013632 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 911045013633 AMP-binding enzyme; Region: AMP-binding; cl15778 911045013634 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045013635 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 911045013636 active site 911045013637 catalytic residues [active] 911045013638 metal binding site [ion binding]; metal-binding site 911045013639 enoyl-CoA hydratase; Provisional; Region: PRK07468 911045013640 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045013641 substrate binding site [chemical binding]; other site 911045013642 oxyanion hole (OAH) forming residues; other site 911045013643 trimer interface [polypeptide binding]; other site 911045013644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045013645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045013646 putative substrate translocation pore; other site 911045013647 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 911045013648 catalytic triad [active] 911045013649 conserved cis-peptide bond; other site 911045013650 Isochorismatase family; Region: Isochorismatase; pfam00857 911045013651 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 911045013652 catalytic triad [active] 911045013653 conserved cis-peptide bond; other site 911045013654 Isochorismatase family; Region: Isochorismatase; pfam00857 911045013655 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 911045013656 catalytic triad [active] 911045013657 conserved cis-peptide bond; other site 911045013658 Isochorismatase family; Region: Isochorismatase; pfam00857 911045013659 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 911045013660 catalytic triad [active] 911045013661 conserved cis-peptide bond; other site 911045013662 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045013663 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 911045013664 conserved cys residue [active] 911045013665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045013666 Isochorismatase family; Region: Isochorismatase; pfam00857 911045013667 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 911045013668 catalytic triad [active] 911045013669 conserved cis-peptide bond; other site 911045013670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 911045013671 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 911045013672 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045013673 catalytic loop [active] 911045013674 iron binding site [ion binding]; other site 911045013675 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 911045013676 FAD binding pocket [chemical binding]; other site 911045013677 FAD binding motif [chemical binding]; other site 911045013678 phosphate binding motif [ion binding]; other site 911045013679 beta-alpha-beta structure motif; other site 911045013680 NAD binding pocket [chemical binding]; other site 911045013681 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 911045013682 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 911045013683 FMN-binding domain; Region: FMN_bind; cl01081 911045013684 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 911045013685 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 911045013686 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 911045013687 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 911045013688 ApbE family; Region: ApbE; cl00643 911045013689 Protein of unknown function (DUF539); Region: DUF539; cl01129 911045013690 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 911045013691 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 911045013692 ATP binding site [chemical binding]; other site 911045013693 Mg++ binding site [ion binding]; other site 911045013694 motif III; other site 911045013695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045013696 nucleotide binding region [chemical binding]; other site 911045013697 ATP-binding site [chemical binding]; other site 911045013698 DbpA RNA binding domain; Region: DbpA; pfam03880 911045013699 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 911045013700 amidase; Provisional; Region: PRK07056 911045013701 Amidase; Region: Amidase; cl11426 911045013702 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 911045013703 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 911045013704 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 911045013705 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 911045013706 RNA binding site [nucleotide binding]; other site 911045013707 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045013708 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 911045013709 EamA-like transporter family; Region: EamA; cl01037 911045013710 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045013711 EamA-like transporter family; Region: EamA; cl01037 911045013712 Helix-turn-helix domains; Region: HTH; cl00088 911045013713 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045013714 active site 911045013715 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045013716 Family description; Region: UvrD_C_2; cl15862 911045013717 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 911045013718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045013719 catalytic residue [active] 911045013720 Phosphotransferase enzyme family; Region: APH; pfam01636 911045013721 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045013722 active site 911045013723 substrate binding site [chemical binding]; other site 911045013724 ATP binding site [chemical binding]; other site 911045013725 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 911045013726 homodimer interface [polypeptide binding]; other site 911045013727 homotetramer interface [polypeptide binding]; other site 911045013728 active site pocket [active] 911045013729 cleavage site 911045013730 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 911045013731 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045013732 substrate binding site [chemical binding]; other site 911045013733 ATP binding site [chemical binding]; other site 911045013734 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045013735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045013736 DNA-binding site [nucleotide binding]; DNA binding site 911045013737 FCD domain; Region: FCD; cl11656 911045013738 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 911045013739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013740 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045013741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 911045013742 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045013743 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045013744 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 911045013745 active site 911045013746 catalytic tetrad [active] 911045013747 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 911045013748 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 911045013749 arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693 911045013750 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 911045013751 molybdopterin cofactor binding site; other site 911045013752 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 911045013753 molybdopterin cofactor binding site; other site 911045013754 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 911045013755 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 911045013756 iron-sulfur cluster [ion binding]; other site 911045013757 [2Fe-2S] cluster binding site [ion binding]; other site 911045013758 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 911045013759 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 911045013760 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045013761 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 911045013762 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 911045013763 putative switch regulator; other site 911045013764 non-specific DNA interactions [nucleotide binding]; other site 911045013765 DNA binding site [nucleotide binding] 911045013766 sequence specific DNA binding site [nucleotide binding]; other site 911045013767 putative cAMP binding site [chemical binding]; other site 911045013768 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045013769 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 911045013770 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 911045013771 Helix-turn-helix domains; Region: HTH; cl00088 911045013772 WYL domain; Region: WYL; cl14852 911045013773 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 911045013774 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045013775 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045013776 Helix-turn-helix domains; Region: HTH; cl00088 911045013777 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 911045013778 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045013779 substrate binding site [chemical binding]; other site 911045013780 oxyanion hole (OAH) forming residues; other site 911045013781 trimer interface [polypeptide binding]; other site 911045013782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013783 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045013784 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045013785 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045013786 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 911045013787 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045013788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045013789 dimer interface [polypeptide binding]; other site 911045013790 conserved gate region; other site 911045013791 putative PBP binding loops; other site 911045013792 ABC-ATPase subunit interface; other site 911045013793 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 911045013794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045013795 dimer interface [polypeptide binding]; other site 911045013796 conserved gate region; other site 911045013797 putative PBP binding loops; other site 911045013798 ABC-ATPase subunit interface; other site 911045013799 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 911045013800 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 911045013801 Walker A/P-loop; other site 911045013802 ATP binding site [chemical binding]; other site 911045013803 Q-loop/lid; other site 911045013804 ABC transporter signature motif; other site 911045013805 Walker B; other site 911045013806 D-loop; other site 911045013807 H-loop/switch region; other site 911045013808 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 911045013809 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 911045013810 Walker A/P-loop; other site 911045013811 ATP binding site [chemical binding]; other site 911045013812 Q-loop/lid; other site 911045013813 ABC transporter signature motif; other site 911045013814 Walker B; other site 911045013815 D-loop; other site 911045013816 H-loop/switch region; other site 911045013817 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 911045013818 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 911045013819 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 911045013820 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 911045013821 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 911045013822 DNA binding site [nucleotide binding] 911045013823 active site 911045013824 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 911045013825 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 911045013826 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045013827 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 911045013828 NAD binding site [chemical binding]; other site 911045013829 homotetramer interface [polypeptide binding]; other site 911045013830 homodimer interface [polypeptide binding]; other site 911045013831 active site 911045013832 Transcriptional regulator [Transcription]; Region: IclR; COG1414 911045013833 Helix-turn-helix domains; Region: HTH; cl00088 911045013834 Bacterial transcriptional regulator; Region: IclR; pfam01614 911045013835 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045013836 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 911045013837 active site 911045013838 catalytic tetrad [active] 911045013839 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 911045013840 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045013841 SAF domain; Region: SAF; cl00555 911045013842 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 911045013843 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 911045013844 Cupin domain; Region: Cupin_2; cl09118 911045013845 Helix-turn-helix domain; Region: HTH_18; pfam12833 911045013846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045013847 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 911045013848 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045013849 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045013850 active site 911045013851 metal binding site [ion binding]; metal-binding site 911045013852 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045013853 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 911045013854 DNA binding residues [nucleotide binding] 911045013855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013856 NAD(P) binding site [chemical binding]; other site 911045013857 active site 911045013858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045013859 Helix-turn-helix domains; Region: HTH; cl00088 911045013860 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045013861 dimerization interface [polypeptide binding]; other site 911045013862 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 911045013863 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045013864 PYR/PP interface [polypeptide binding]; other site 911045013865 dimer interface [polypeptide binding]; other site 911045013866 TPP binding site [chemical binding]; other site 911045013867 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 911045013868 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 911045013869 TPP-binding site [chemical binding]; other site 911045013870 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045013871 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045013872 DNA-binding site [nucleotide binding]; DNA binding site 911045013873 FCD domain; Region: FCD; cl11656 911045013874 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 911045013875 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 911045013876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013877 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045013878 dimerization interface [polypeptide binding]; other site 911045013879 putative DNA binding site [nucleotide binding]; other site 911045013880 putative Zn2+ binding site [ion binding]; other site 911045013881 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 911045013882 putative hydrophobic ligand binding site [chemical binding]; other site 911045013883 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 911045013884 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045013885 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045013886 dimer interface [polypeptide binding]; other site 911045013887 putative CheW interface [polypeptide binding]; other site 911045013888 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 911045013889 LysE type translocator; Region: LysE; cl00565 911045013890 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 911045013891 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045013892 FeS/SAM binding site; other site 911045013893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 911045013894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045013896 S-adenosylmethionine binding site [chemical binding]; other site 911045013897 SCP-2 sterol transfer family; Region: SCP2; cl01225 911045013898 Predicted esterase [General function prediction only]; Region: COG0627 911045013899 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045013900 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 911045013901 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 911045013902 substrate binding site [chemical binding]; other site 911045013903 catalytic Zn binding site [ion binding]; other site 911045013904 NAD binding site [chemical binding]; other site 911045013905 structural Zn binding site [ion binding]; other site 911045013906 dimer interface [polypeptide binding]; other site 911045013907 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 911045013908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045013909 H+ Antiporter protein; Region: 2A0121; TIGR00900 911045013910 putative substrate translocation pore; other site 911045013911 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045013912 dimerization interface [polypeptide binding]; other site 911045013913 putative DNA binding site [nucleotide binding]; other site 911045013914 putative Zn2+ binding site [ion binding]; other site 911045013915 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045013916 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 911045013917 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045013918 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045013919 active site 911045013920 metal binding site [ion binding]; metal-binding site 911045013921 Putative cyclase; Region: Cyclase; cl00814 911045013922 putative transcriptional regulator; Provisional; Region: PRK11640 911045013923 Helix-turn-helix domains; Region: HTH; cl00088 911045013924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 911045013925 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 911045013926 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 911045013927 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 911045013928 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 911045013929 active site pocket [active] 911045013930 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045013931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045013932 DNA-binding site [nucleotide binding]; DNA binding site 911045013933 FCD domain; Region: FCD; cl11656 911045013934 FAD dependent oxidoreductase; Region: DAO; pfam01266 911045013935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013936 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 911045013937 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045013938 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 911045013939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045013940 non-specific DNA binding site [nucleotide binding]; other site 911045013941 salt bridge; other site 911045013942 sequence-specific DNA binding site [nucleotide binding]; other site 911045013943 Cupin domain; Region: Cupin_2; cl09118 911045013944 FAD dependent oxidoreductase; Region: DAO; pfam01266 911045013945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013946 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045013947 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 911045013948 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 911045013949 NAD binding site [chemical binding]; other site 911045013950 homotetramer interface [polypeptide binding]; other site 911045013951 homodimer interface [polypeptide binding]; other site 911045013952 substrate binding site [chemical binding]; other site 911045013953 active site 911045013954 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 911045013955 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 911045013956 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 911045013957 dimer interaction site [polypeptide binding]; other site 911045013958 substrate-binding tunnel; other site 911045013959 active site 911045013960 catalytic site [active] 911045013961 substrate binding site [chemical binding]; other site 911045013962 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 911045013963 Acetokinase family; Region: Acetate_kinase; cl01029 911045013964 propionate/acetate kinase; Provisional; Region: PRK12379 911045013965 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 911045013966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045013967 Coenzyme A binding pocket [chemical binding]; other site 911045013968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045013969 Helix-turn-helix domains; Region: HTH; cl00088 911045013970 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045013971 dimerization interface [polypeptide binding]; other site 911045013972 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 911045013973 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045013974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045013975 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 911045013976 active site 911045013977 dimer interface [polypeptide binding]; other site 911045013978 catalytic nucleophile [active] 911045013979 CutC family; Region: CutC; cl01218 911045013980 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045013981 Helix-turn-helix domains; Region: HTH; cl00088 911045013982 Helix-turn-helix domains; Region: HTH; cl00088 911045013983 polysaccharide export protein Wza; Provisional; Region: PRK15078 911045013984 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 911045013985 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045013986 homotrimer interaction site [polypeptide binding]; other site 911045013987 putative active site [active] 911045013988 pyridoxamine kinase; Validated; Region: PRK05756 911045013989 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 911045013990 pyridoxal binding site [chemical binding]; other site 911045013991 dimer interface [polypeptide binding]; other site 911045013992 ATP binding site [chemical binding]; other site 911045013993 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 911045013994 aromatic amino acid transport protein; Region: araaP; TIGR00837 911045013995 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 911045013996 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 911045013997 substrate binding site [chemical binding]; other site 911045013998 tetramer interface [polypeptide binding]; other site 911045013999 catalytic residue [active] 911045014000 Superfamily II helicase [General function prediction only]; Region: COG1204 911045014001 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045014002 ATP binding site [chemical binding]; other site 911045014003 putative Mg++ binding site [ion binding]; other site 911045014004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045014005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045014006 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045014007 putative substrate translocation pore; other site 911045014008 Salmonella virulence-associated 28kDa protein; Region: VRP3; cl04142 911045014009 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 911045014010 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045014011 substrate binding site [chemical binding]; other site 911045014012 oxyanion hole (OAH) forming residues; other site 911045014013 trimer interface [polypeptide binding]; other site 911045014014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014015 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045014016 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 911045014017 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 911045014018 dimer interface [polypeptide binding]; other site 911045014019 active site 911045014020 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 911045014021 AMP-binding enzyme; Region: AMP-binding; cl15778 911045014022 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 911045014023 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 911045014024 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 911045014025 putative ligand binding site [chemical binding]; other site 911045014026 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 911045014027 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 911045014028 AP (apurinic/apyrimidinic) site pocket; other site 911045014029 DNA interaction; other site 911045014030 Metal-binding active site; metal-binding site 911045014031 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 911045014032 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 911045014033 putative ligand binding site [chemical binding]; other site 911045014034 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 911045014035 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 911045014036 Walker A/P-loop; other site 911045014037 ATP binding site [chemical binding]; other site 911045014038 Q-loop/lid; other site 911045014039 ABC transporter signature motif; other site 911045014040 Walker B; other site 911045014041 D-loop; other site 911045014042 H-loop/switch region; other site 911045014043 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 911045014044 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 911045014045 TM-ABC transporter signature motif; other site 911045014046 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045014047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014048 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 911045014049 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045014050 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045014051 Walker A/P-loop; other site 911045014052 ATP binding site [chemical binding]; other site 911045014053 Q-loop/lid; other site 911045014054 ABC transporter signature motif; other site 911045014055 Walker B; other site 911045014056 D-loop; other site 911045014057 H-loop/switch region; other site 911045014058 TOBE domain; Region: TOBE_2; cl01440 911045014059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014060 dimer interface [polypeptide binding]; other site 911045014061 conserved gate region; other site 911045014062 putative PBP binding loops; other site 911045014063 ABC-ATPase subunit interface; other site 911045014064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014065 dimer interface [polypeptide binding]; other site 911045014066 conserved gate region; other site 911045014067 putative PBP binding loops; other site 911045014068 ABC-ATPase subunit interface; other site 911045014069 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045014070 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045014071 hypothetical protein; Provisional; Region: PRK05968 911045014072 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 911045014073 homodimer interface [polypeptide binding]; other site 911045014074 substrate-cofactor binding pocket; other site 911045014075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045014076 catalytic residue [active] 911045014077 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045014078 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045014079 DNA-binding site [nucleotide binding]; DNA binding site 911045014080 FCD domain; Region: FCD; cl11656 911045014081 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045014082 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045014083 DNA binding site [nucleotide binding] 911045014084 domain linker motif; other site 911045014085 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 911045014086 dimerization interface [polypeptide binding]; other site 911045014087 ligand binding site [chemical binding]; other site 911045014088 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045014089 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045014090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014091 dimer interface [polypeptide binding]; other site 911045014092 conserved gate region; other site 911045014093 putative PBP binding loops; other site 911045014094 ABC-ATPase subunit interface; other site 911045014095 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045014096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014097 dimer interface [polypeptide binding]; other site 911045014098 conserved gate region; other site 911045014099 putative PBP binding loops; other site 911045014100 ABC-ATPase subunit interface; other site 911045014101 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045014102 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045014103 Walker A/P-loop; other site 911045014104 ATP binding site [chemical binding]; other site 911045014105 Q-loop/lid; other site 911045014106 ABC transporter signature motif; other site 911045014107 Walker B; other site 911045014108 D-loop; other site 911045014109 H-loop/switch region; other site 911045014110 TOBE domain; Region: TOBE_2; cl01440 911045014111 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 911045014112 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 911045014113 dimer interface [polypeptide binding]; other site 911045014114 active site 911045014115 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045014116 substrate binding site [chemical binding]; other site 911045014117 catalytic residue [active] 911045014118 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 911045014119 TPP-binding site [chemical binding]; other site 911045014120 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 911045014121 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 911045014122 PYR/PP interface [polypeptide binding]; other site 911045014123 dimer interface [polypeptide binding]; other site 911045014124 TPP binding site [chemical binding]; other site 911045014125 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 911045014126 Putative ammonia monooxygenase; Region: AmoA; pfam05145 911045014127 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 911045014128 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 911045014129 NMT1-like family; Region: NMT1_2; cl15260 911045014130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045014131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045014132 active site 911045014133 phosphorylation site [posttranslational modification] 911045014134 intermolecular recognition site; other site 911045014135 dimerization interface [polypeptide binding]; other site 911045014136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045014137 DNA binding site [nucleotide binding] 911045014138 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 911045014139 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045014140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045014141 dimer interface [polypeptide binding]; other site 911045014142 phosphorylation site [posttranslational modification] 911045014143 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 911045014144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045014145 ATP binding site [chemical binding]; other site 911045014146 Mg2+ binding site [ion binding]; other site 911045014147 G-X-G motif; other site 911045014148 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 911045014149 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045014150 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045014151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045014152 Coenzyme A binding pocket [chemical binding]; other site 911045014153 H+ Antiporter protein; Region: 2A0121; TIGR00900 911045014154 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045014155 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045014156 DNA-binding site [nucleotide binding]; DNA binding site 911045014157 FCD domain; Region: FCD; cl11656 911045014158 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045014159 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045014160 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045014161 DctM-like transporters; Region: DctM; pfam06808 911045014162 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045014163 SAF domain; Region: SAF; cl00555 911045014164 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 911045014165 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 911045014166 altronate oxidoreductase; Provisional; Region: PRK03643 911045014167 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 911045014168 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 911045014169 Glucuronate isomerase; Region: UxaC; cl00829 911045014170 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045014171 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 911045014172 substrate binding site [chemical binding]; other site 911045014173 ATP binding site [chemical binding]; other site 911045014174 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045014175 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045014176 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045014177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045014178 DNA-binding site [nucleotide binding]; DNA binding site 911045014179 FCD domain; Region: FCD; cl11656 911045014180 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 911045014181 BCCT family transporter; Region: BCCT; cl00569 911045014182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045014183 DNA-binding site [nucleotide binding]; DNA binding site 911045014184 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 911045014185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045014186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045014187 homodimer interface [polypeptide binding]; other site 911045014188 catalytic residue [active] 911045014189 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 911045014190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045014191 substrate binding site [chemical binding]; other site 911045014192 oxyanion hole (OAH) forming residues; other site 911045014193 trimer interface [polypeptide binding]; other site 911045014194 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 911045014195 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045014196 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045014197 PAAR motif; Region: PAAR_motif; cl15808 911045014198 D123; Region: D123; pfam07065 911045014199 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 911045014200 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 911045014201 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 911045014202 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 911045014203 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 911045014204 Protein of unknown function (DUF796); Region: DUF796; cl01226 911045014205 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 911045014206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014207 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045014208 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 911045014209 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045014210 enoyl-CoA hydratase; Provisional; Region: PRK08138 911045014211 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045014212 substrate binding site [chemical binding]; other site 911045014213 oxyanion hole (OAH) forming residues; other site 911045014214 trimer interface [polypeptide binding]; other site 911045014215 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 911045014216 CoA-transferase family III; Region: CoA_transf_3; pfam02515 911045014217 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045014218 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045014219 DNA binding site [nucleotide binding] 911045014220 domain linker motif; other site 911045014221 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 911045014222 dimerization interface [polypeptide binding]; other site 911045014223 ligand binding site [chemical binding]; other site 911045014224 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045014225 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045014226 DctM-like transporters; Region: DctM; pfam06808 911045014227 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045014228 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045014229 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045014230 classical (c) SDRs; Region: SDR_c; cd05233 911045014231 NAD(P) binding site [chemical binding]; other site 911045014232 active site 911045014233 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 911045014234 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 911045014235 putative NAD(P) binding site [chemical binding]; other site 911045014236 catalytic Zn binding site [ion binding]; other site 911045014237 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 911045014238 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045014239 substrate binding site [chemical binding]; other site 911045014240 ATP binding site [chemical binding]; other site 911045014241 BCCT family transporter; Region: BCCT; cl00569 911045014242 Putative cyclase; Region: Cyclase; cl00814 911045014243 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 911045014244 protein-splicing catalytic site; other site 911045014245 thioester formation/cholesterol transfer; other site 911045014246 Pretoxin HINT domain; Region: PT-HINT; pfam07591 911045014247 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 911045014248 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045014249 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045014250 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045014251 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045014252 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 911045014253 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045014254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045014255 Helix-turn-helix domains; Region: HTH; cl00088 911045014256 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 911045014257 Protein of unknown function (DUF962); Region: DUF962; cl01879 911045014258 putative acetyltransferase; Provisional; Region: PRK03624 911045014259 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045014260 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 911045014261 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045014262 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 911045014263 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 911045014264 FecR protein; Region: FecR; pfam04773 911045014265 Secretin and TonB N terminus short domain; Region: STN; cl06624 911045014266 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 911045014267 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 911045014268 malonyl-CoA synthase; Validated; Region: PRK07514 911045014269 AMP-binding enzyme; Region: AMP-binding; cl15778 911045014270 AMP-binding enzyme; Region: AMP-binding; cl15778 911045014271 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 911045014272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045014273 S-adenosylmethionine binding site [chemical binding]; other site 911045014274 LysE type translocator; Region: LysE; cl00565 911045014275 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 911045014276 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045014277 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045014278 DNA binding residues [nucleotide binding] 911045014279 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 911045014280 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045014281 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045014282 putative S-transferase; Provisional; Region: PRK11752 911045014283 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 911045014284 C-terminal domain interface [polypeptide binding]; other site 911045014285 GSH binding site (G-site) [chemical binding]; other site 911045014286 dimer interface [polypeptide binding]; other site 911045014287 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 911045014288 dimer interface [polypeptide binding]; other site 911045014289 N-terminal domain interface [polypeptide binding]; other site 911045014290 active site 911045014291 hypothetical protein; Provisional; Region: PRK10977 911045014292 Glycine radical; Region: Gly_radical; cl12026 911045014293 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 911045014294 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 911045014295 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 911045014296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045014297 FeS/SAM binding site; other site 911045014298 Cupin domain; Region: Cupin_2; cl09118 911045014299 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045014300 Isochorismatase family; Region: Isochorismatase; pfam00857 911045014301 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 911045014302 catalytic triad [active] 911045014303 conserved cis-peptide bond; other site 911045014304 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 911045014305 classical (c) SDRs; Region: SDR_c; cd05233 911045014306 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 911045014307 NAD(P) binding site [chemical binding]; other site 911045014308 active site 911045014309 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045014310 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045014311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014312 dimer interface [polypeptide binding]; other site 911045014313 conserved gate region; other site 911045014314 putative PBP binding loops; other site 911045014315 ABC-ATPase subunit interface; other site 911045014316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014317 dimer interface [polypeptide binding]; other site 911045014318 conserved gate region; other site 911045014319 putative PBP binding loops; other site 911045014320 ABC-ATPase subunit interface; other site 911045014321 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045014322 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 911045014323 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045014324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 911045014325 Walker A/P-loop; other site 911045014326 ATP binding site [chemical binding]; other site 911045014327 Q-loop/lid; other site 911045014328 ABC transporter signature motif; other site 911045014329 Walker B; other site 911045014330 D-loop; other site 911045014331 H-loop/switch region; other site 911045014332 TOBE domain; Region: TOBE_2; cl01440 911045014333 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 911045014334 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 911045014335 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 911045014336 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 911045014337 PhoU domain; Region: PhoU; pfam01895 911045014338 PhoU domain; Region: PhoU; pfam01895 911045014339 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 911045014340 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 911045014341 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 911045014342 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045014343 MatE; Region: MatE; cl10513 911045014344 MatE; Region: MatE; cl10513 911045014345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045014346 non-specific DNA binding site [nucleotide binding]; other site 911045014347 salt bridge; other site 911045014348 sequence-specific DNA binding site [nucleotide binding]; other site 911045014349 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 911045014350 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 911045014351 active site 911045014352 8-oxo-dGMP binding site [chemical binding]; other site 911045014353 nudix motif; other site 911045014354 metal binding site [ion binding]; metal-binding site 911045014355 RF-1 domain; Region: RF-1; cl02875 911045014356 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 911045014357 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045014358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014359 NAD(P) binding site [chemical binding]; other site 911045014360 active site 911045014361 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 911045014362 Sodium:solute symporter family; Region: SSF; cl00456 911045014363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045014364 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045014365 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 911045014366 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 911045014367 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 911045014368 malonyl-CoA binding site [chemical binding]; other site 911045014369 dimer interface [polypeptide binding]; other site 911045014370 active site 911045014371 product binding site; other site 911045014372 Phospholipid methyltransferase; Region: PEMT; cl00763 911045014373 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045014374 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 911045014375 dimer interface [polypeptide binding]; other site 911045014376 NADP binding site [chemical binding]; other site 911045014377 catalytic residues [active] 911045014378 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045014379 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 911045014380 Walker A/P-loop; other site 911045014381 ATP binding site [chemical binding]; other site 911045014382 Q-loop/lid; other site 911045014383 ABC transporter signature motif; other site 911045014384 Walker B; other site 911045014385 D-loop; other site 911045014386 H-loop/switch region; other site 911045014387 TOBE domain; Region: TOBE_2; cl01440 911045014388 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045014389 putative catalytic site [active] 911045014390 putative metal binding site [ion binding]; other site 911045014391 putative phosphate binding site [ion binding]; other site 911045014392 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045014393 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045014394 DNA binding site [nucleotide binding] 911045014395 domain linker motif; other site 911045014396 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 911045014397 dimerization interface [polypeptide binding]; other site 911045014398 ligand binding site [chemical binding]; other site 911045014399 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 911045014400 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045014401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014402 dimer interface [polypeptide binding]; other site 911045014403 conserved gate region; other site 911045014404 putative PBP binding loops; other site 911045014405 ABC-ATPase subunit interface; other site 911045014406 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045014407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014408 dimer interface [polypeptide binding]; other site 911045014409 conserved gate region; other site 911045014410 putative PBP binding loops; other site 911045014411 ABC-ATPase subunit interface; other site 911045014412 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 911045014413 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045014414 Cupin domain; Region: Cupin_2; cl09118 911045014415 Fic/DOC family; Region: Fic; cl00960 911045014416 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 911045014417 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 911045014418 active site 911045014419 Acyl transferase domain; Region: Acyl_transf_1; cl08282 911045014420 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 911045014421 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 911045014422 Enoylreductase; Region: PKS_ER; smart00829 911045014423 NAD(P) binding site [chemical binding]; other site 911045014424 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 911045014425 putative NADP binding site [chemical binding]; other site 911045014426 active site 911045014427 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045014428 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 911045014429 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 911045014430 substrate-cofactor binding pocket; other site 911045014431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045014432 catalytic residue [active] 911045014433 short chain dehydrogenase; Provisional; Region: PRK06101 911045014434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014435 NAD(P) binding site [chemical binding]; other site 911045014436 active site 911045014437 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 911045014438 polysaccharide export protein Wza; Provisional; Region: PRK15078 911045014439 SLBB domain; Region: SLBB; pfam10531 911045014440 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 911045014441 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 911045014442 Walker A/P-loop; other site 911045014443 ATP binding site [chemical binding]; other site 911045014444 ABC transporter; Region: ABC_tran; pfam00005 911045014445 Q-loop/lid; other site 911045014446 ABC transporter signature motif; other site 911045014447 Walker B; other site 911045014448 D-loop; other site 911045014449 H-loop/switch region; other site 911045014450 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 911045014451 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 911045014452 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 911045014453 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 911045014454 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 911045014455 active site 911045014456 cosubstrate binding site; other site 911045014457 substrate binding site [chemical binding]; other site 911045014458 catalytic site [active] 911045014459 EamA-like transporter family; Region: EamA; cl01037 911045014460 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 911045014461 Cytochrome P450; Region: p450; pfam00067 911045014462 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 911045014463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045014464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045014465 Coenzyme A binding pocket [chemical binding]; other site 911045014466 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 911045014467 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045014468 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 911045014469 probable polyamine oxidase; Region: PLN02268 911045014470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014472 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 911045014473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045014474 active site 911045014475 motif I; other site 911045014476 motif II; other site 911045014477 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045014478 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045014479 DNA binding site [nucleotide binding] 911045014480 domain linker motif; other site 911045014481 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 911045014482 dimerization interface [polypeptide binding]; other site 911045014483 ligand binding site [chemical binding]; other site 911045014484 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 911045014485 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045014486 Walker A/P-loop; other site 911045014487 ATP binding site [chemical binding]; other site 911045014488 Q-loop/lid; other site 911045014489 ABC transporter signature motif; other site 911045014490 Walker B; other site 911045014491 D-loop; other site 911045014492 H-loop/switch region; other site 911045014493 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045014494 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045014495 Walker A/P-loop; other site 911045014496 ATP binding site [chemical binding]; other site 911045014497 Q-loop/lid; other site 911045014498 ABC transporter signature motif; other site 911045014499 Walker B; other site 911045014500 D-loop; other site 911045014501 H-loop/switch region; other site 911045014502 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045014503 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045014504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014505 dimer interface [polypeptide binding]; other site 911045014506 conserved gate region; other site 911045014507 putative PBP binding loops; other site 911045014508 ABC-ATPase subunit interface; other site 911045014509 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045014510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014511 dimer interface [polypeptide binding]; other site 911045014512 conserved gate region; other site 911045014513 putative PBP binding loops; other site 911045014514 ABC-ATPase subunit interface; other site 911045014515 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045014516 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045014517 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045014518 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045014519 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045014520 DNA binding site [nucleotide binding] 911045014521 domain linker motif; other site 911045014522 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 911045014523 dimerization interface [polypeptide binding]; other site 911045014524 ligand binding site [chemical binding]; other site 911045014525 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 911045014526 conserved cys residue [active] 911045014527 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045014528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014529 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 911045014530 PAS domain; Region: PAS_9; pfam13426 911045014531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045014532 putative active site [active] 911045014533 heme pocket [chemical binding]; other site 911045014534 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045014535 metal binding site [ion binding]; metal-binding site 911045014536 active site 911045014537 I-site; other site 911045014538 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045014539 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045014540 EamA-like transporter family; Region: EamA; cl01037 911045014541 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045014542 dimerization interface [polypeptide binding]; other site 911045014543 putative DNA binding site [nucleotide binding]; other site 911045014544 putative Zn2+ binding site [ion binding]; other site 911045014545 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 911045014546 putative hydrophobic ligand binding site [chemical binding]; other site 911045014547 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 911045014548 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 911045014549 putative metal binding site; other site 911045014550 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 911045014551 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 911045014552 active site 911045014553 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 911045014554 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 911045014555 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 911045014556 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045014557 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045014558 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045014559 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045014560 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 911045014561 Sulfatase; Region: Sulfatase; cl10460 911045014562 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 911045014563 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045014564 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045014565 dimer interface [polypeptide binding]; other site 911045014566 putative CheW interface [polypeptide binding]; other site 911045014567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045014568 PAS fold; Region: PAS_3; pfam08447 911045014569 putative active site [active] 911045014570 heme pocket [chemical binding]; other site 911045014571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045014572 dimerization interface [polypeptide binding]; other site 911045014573 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 911045014574 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045014575 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045014576 dimer interface [polypeptide binding]; other site 911045014577 putative CheW interface [polypeptide binding]; other site 911045014578 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045014579 active site 911045014580 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 911045014581 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 911045014582 putative active site [active] 911045014583 metal binding site [ion binding]; metal-binding site 911045014584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045014585 putative substrate translocation pore; other site 911045014586 H+ Antiporter protein; Region: 2A0121; TIGR00900 911045014587 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045014588 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 911045014589 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045014590 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 911045014591 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 911045014592 homotrimer interaction site [polypeptide binding]; other site 911045014593 putative active site [active] 911045014594 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 911045014595 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 911045014596 NADP binding site [chemical binding]; other site 911045014597 active site 911045014598 putative substrate binding site [chemical binding]; other site 911045014599 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 911045014600 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 911045014601 NADP-binding site; other site 911045014602 homotetramer interface [polypeptide binding]; other site 911045014603 substrate binding site [chemical binding]; other site 911045014604 homodimer interface [polypeptide binding]; other site 911045014605 active site 911045014606 putative chaperone; Provisional; Region: PRK11678 911045014607 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045014608 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045014609 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045014610 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045014611 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045014612 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045014613 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 911045014614 N-terminal domain interface [polypeptide binding]; other site 911045014615 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 911045014616 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 911045014617 tetramer interface [polypeptide binding]; other site 911045014618 active site 911045014619 Mg2+/Mn2+ binding site [ion binding]; other site 911045014620 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 911045014621 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 911045014622 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 911045014623 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 911045014624 DNA binding site [nucleotide binding] 911045014625 active site 911045014626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045014627 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 911045014628 Coenzyme A binding pocket [chemical binding]; other site 911045014629 Helix-turn-helix domains; Region: HTH; cl00088 911045014630 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 911045014631 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 911045014632 ParB-like nuclease domain; Region: ParBc; cl02129 911045014633 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 911045014634 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045014635 DNA binding residues [nucleotide binding] 911045014636 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045014637 P-loop; other site 911045014638 Magnesium ion binding site [ion binding]; other site 911045014639 ATP-grasp domain; Region: ATP-grasp_4; cl03087 911045014640 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045014641 classical (c) SDRs; Region: SDR_c; cd05233 911045014642 NAD(P) binding site [chemical binding]; other site 911045014643 active site 911045014644 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045014645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045014646 Coenzyme A binding pocket [chemical binding]; other site 911045014647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045014648 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045014649 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045014650 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 911045014651 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 911045014652 tetramer interface [polypeptide binding]; other site 911045014653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045014654 catalytic residue [active] 911045014655 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 911045014656 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 911045014657 short chain dehydrogenase; Validated; Region: PRK06182 911045014658 NADP binding site [chemical binding]; other site 911045014659 active site 911045014660 steroid binding site; other site 911045014661 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 911045014662 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 911045014663 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 911045014664 dimer interface [polypeptide binding]; other site 911045014665 PYR/PP interface [polypeptide binding]; other site 911045014666 TPP binding site [chemical binding]; other site 911045014667 substrate binding site [chemical binding]; other site 911045014668 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 911045014669 TPP-binding site [chemical binding]; other site 911045014670 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 911045014671 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045014672 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045014673 DNA binding residues [nucleotide binding] 911045014674 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045014675 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045014676 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 911045014677 N-terminal domain interface [polypeptide binding]; other site 911045014678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045014679 S-adenosylmethionine binding site [chemical binding]; other site 911045014680 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 911045014681 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 911045014682 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 911045014683 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 911045014684 NnrS protein; Region: NnrS; cl01258 911045014685 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045014686 DNA binding residues [nucleotide binding] 911045014687 dimerization interface [polypeptide binding]; other site 911045014688 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 911045014689 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045014690 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045014691 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045014692 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 911045014693 homotrimer interaction site [polypeptide binding]; other site 911045014694 putative active site [active] 911045014695 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 911045014696 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 911045014697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014698 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 911045014699 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 911045014700 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 911045014701 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 911045014702 AMP-binding enzyme; Region: AMP-binding; cl15778 911045014703 AMP-binding enzyme; Region: AMP-binding; cl15778 911045014704 enoyl-CoA hydratase; Provisional; Region: PRK05862 911045014705 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045014706 substrate binding site [chemical binding]; other site 911045014707 oxyanion hole (OAH) forming residues; other site 911045014708 trimer interface [polypeptide binding]; other site 911045014709 transcriptional regulator; Provisional; Region: PRK10632 911045014710 Helix-turn-helix domains; Region: HTH; cl00088 911045014711 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 911045014712 putative effector binding pocket; other site 911045014713 putative dimerization interface [polypeptide binding]; other site 911045014714 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 911045014715 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 911045014716 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 911045014717 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045014718 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 911045014719 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045014720 Helix-turn-helix domains; Region: HTH; cl00088 911045014721 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045014722 dimerization interface [polypeptide binding]; other site 911045014723 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045014724 DctM-like transporters; Region: DctM; pfam06808 911045014725 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045014726 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045014727 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045014728 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 911045014729 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 911045014730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014731 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 911045014732 FAD dependent oxidoreductase; Region: DAO; pfam01266 911045014733 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 911045014734 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 911045014735 homotrimer interaction site [polypeptide binding]; other site 911045014736 putative active site [active] 911045014737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045014738 Helix-turn-helix domains; Region: HTH; cl00088 911045014739 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045014740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045014741 active site 911045014742 phosphorylation site [posttranslational modification] 911045014743 intermolecular recognition site; other site 911045014744 dimerization interface [polypeptide binding]; other site 911045014745 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045014746 DNA binding site [nucleotide binding] 911045014747 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045014748 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045014749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045014750 dimer interface [polypeptide binding]; other site 911045014751 phosphorylation site [posttranslational modification] 911045014752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045014753 ATP binding site [chemical binding]; other site 911045014754 Mg2+ binding site [ion binding]; other site 911045014755 G-X-G motif; other site 911045014756 intracellular protease, PfpI family; Region: PfpI; TIGR01382 911045014757 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 911045014758 conserved cys residue [active] 911045014759 tyramine oxidase; Provisional; Region: tynA; PRK11504 911045014760 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 911045014761 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 911045014762 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 911045014763 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 911045014764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045014765 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 911045014766 Helix-turn-helix domains; Region: HTH; cl00088 911045014767 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 911045014768 putative dimerization interface [polypeptide binding]; other site 911045014769 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 911045014770 gating phenylalanine in ion channel; other site 911045014771 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 911045014772 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 911045014773 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 911045014774 putative active site [active] 911045014775 N-formylglutamate amidohydrolase; Region: FGase; cl01522 911045014776 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045014777 DctM-like transporters; Region: DctM; pfam06808 911045014778 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045014779 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045014780 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045014781 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 911045014782 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 911045014783 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 911045014784 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045014785 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 911045014786 NAD(P) binding site [chemical binding]; other site 911045014787 catalytic residues [active] 911045014788 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 911045014789 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 911045014790 putative active site [active] 911045014791 metal binding site [ion binding]; metal-binding site 911045014792 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045014793 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 911045014794 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 911045014795 active site 911045014796 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 911045014797 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045014798 Walker A/P-loop; other site 911045014799 ATP binding site [chemical binding]; other site 911045014800 Q-loop/lid; other site 911045014801 ABC transporter signature motif; other site 911045014802 Walker B; other site 911045014803 D-loop; other site 911045014804 H-loop/switch region; other site 911045014805 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045014806 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 911045014807 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 911045014808 Walker A/P-loop; other site 911045014809 ATP binding site [chemical binding]; other site 911045014810 Q-loop/lid; other site 911045014811 ABC transporter signature motif; other site 911045014812 Walker B; other site 911045014813 D-loop; other site 911045014814 H-loop/switch region; other site 911045014815 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045014816 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 911045014817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014818 dimer interface [polypeptide binding]; other site 911045014819 conserved gate region; other site 911045014820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045014821 ABC-ATPase subunit interface; other site 911045014822 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045014823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014824 dimer interface [polypeptide binding]; other site 911045014825 conserved gate region; other site 911045014826 putative PBP binding loops; other site 911045014827 ABC-ATPase subunit interface; other site 911045014828 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 911045014829 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045014830 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 911045014831 maleylacetoacetate isomerase; Region: maiA; TIGR01262 911045014832 C-terminal domain interface [polypeptide binding]; other site 911045014833 GSH binding site (G-site) [chemical binding]; other site 911045014834 putative dimer interface [polypeptide binding]; other site 911045014835 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 911045014836 dimer interface [polypeptide binding]; other site 911045014837 N-terminal domain interface [polypeptide binding]; other site 911045014838 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 911045014839 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045014840 Helix-turn-helix domains; Region: HTH; cl00088 911045014841 Helix-turn-helix domains; Region: HTH; cl00088 911045014842 fumarylacetoacetase; Region: PLN02856 911045014843 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 911045014844 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 911045014845 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045014846 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 911045014847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014848 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 911045014849 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 911045014850 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045014851 Zn binding site [ion binding]; other site 911045014852 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045014853 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045014854 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045014855 DctM-like transporters; Region: DctM; pfam06808 911045014856 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045014857 flavin-containing monooxygenase FMO GS-OX; Region: PLN02172 911045014858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014859 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 911045014860 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 911045014861 active site 911045014862 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 911045014863 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 911045014864 tetramer interface [polypeptide binding]; other site 911045014865 active site 911045014866 Mg2+/Mn2+ binding site [ion binding]; other site 911045014867 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045014868 DctM-like transporters; Region: DctM; pfam06808 911045014869 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045014870 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045014871 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045014872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014873 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045014874 NAD(P) binding site [chemical binding]; other site 911045014875 active site 911045014876 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045014877 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 911045014878 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 911045014879 Subunit I/III interface [polypeptide binding]; other site 911045014880 Subunit III/IV interface [polypeptide binding]; other site 911045014881 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 911045014882 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 911045014883 D-pathway; other site 911045014884 Putative ubiquinol binding site [chemical binding]; other site 911045014885 Low-spin heme (heme b) binding site [chemical binding]; other site 911045014886 Putative water exit pathway; other site 911045014887 Binuclear center (heme o3/CuB) [ion binding]; other site 911045014888 K-pathway; other site 911045014889 Putative proton exit pathway; other site 911045014890 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 911045014891 Olfactory receptor; Region: 7tm_4; cl10458 911045014892 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 911045014893 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 911045014894 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045014895 Cytochrome P450; Region: p450; pfam00067 911045014896 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 911045014897 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 911045014898 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 911045014899 active site 911045014900 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045014901 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 911045014902 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 911045014903 active site 911045014904 nucleophile elbow; other site 911045014905 Patatin phospholipase; Region: DUF3734; pfam12536 911045014906 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045014907 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 911045014908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045014909 putative substrate translocation pore; other site 911045014910 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045014911 homotrimer interaction site [polypeptide binding]; other site 911045014912 putative active site [active] 911045014913 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 911045014914 aspartate aminotransferase; Provisional; Region: PRK06108 911045014915 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045014916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045014917 homodimer interface [polypeptide binding]; other site 911045014918 catalytic residue [active] 911045014919 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045014920 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045014921 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 911045014922 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 911045014923 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 911045014924 Walker A/P-loop; other site 911045014925 ATP binding site [chemical binding]; other site 911045014926 Q-loop/lid; other site 911045014927 ABC transporter signature motif; other site 911045014928 Walker B; other site 911045014929 D-loop; other site 911045014930 H-loop/switch region; other site 911045014931 DctM-like transporters; Region: DctM; pfam06808 911045014932 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 911045014933 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045014934 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045014935 FAD dependent oxidoreductase; Region: DAO; pfam01266 911045014936 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 911045014937 substrate binding pocket [chemical binding]; other site